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in august 2013 , a 9-year - old girl who was returning to france after a 1-month stay with her family in casablanca , morocco , was admitted to lille university hospital in lille .
symptoms started in casablanca 3 days before hospital admission and included fever , severe diarrhea ( > 10 liquid defecations / day ) , ... | despite increasing reports that blastocystis infection is associated with digestive symptoms , its pathogenicity remains controversial .
we report appendicular peritonitis in a 9-year - old girl returning to france from morocco .
only blastocystis parasites were detected in stools , appendix , peritoneal liquid , a... |
terra preta soils were likely formed between 500 and 2500 years ago by pre - columbian populations .
these soils are found in the amazonian region distinguished by the presence of ceramic artifacts , animal bones and high amounts of charred organic materials , which are commonly referred as black carbon ( bc ) .... | the anthropogenic amazon dark earth soil is considered one of the world 's most fertile soils .
these soils differs from conventional amazon soils because its higher organic content concentration . here
we describe the metagenome sequencing of microbial communities of two sites of anthropogenic amazon dark earth so... |
smoking affects vascular and hormonal systems and is also involved in the development of atherosclerosis , thrombogenesis and vascular occlusion .
chronic smoking adversely influences the prognosis of nephropathies . in primary hypertension , urinary albumin excretion as an index of renal damage
the rate of progres... | smoking is associated with an excessive morbidity and mortality from a variety of diseases .
the aim of this study was to find out the effects of smoking on renal function study in non - diabetic , normotensive subjects . a community - based , prospective , cross - sectional cohort study
was conducted on 120 subjec... |
ace inhibitors and arbs , the most potent antihypertensive and renoprotective pharmaceutical agents also recognized for their cardioprotective activity , have been widely applied to a number of illnesses .
these agents function by interruption of the production or action of angiotensin ii , which is the main end - pr... | angiotensin - converting enzyme ( ace ) inhibitors and angiotensin ii ( at ii ) receptor blockers ( arbs ) are widely used antihypertensives with well - recognized renoprotective and cardioprotective effects .
although treatment with these agents generally does not result in adverse metabolic consequences , their use... |
numerical and structural centrosome abnormalities are hallmarks of various cancers and have been implicated in the generation of multipolar mitoses and chromosomal instability .
centrosomes function as major microtubule organizing centers in animal and human cells and thus contribute importantly to proper spindle for... | numerical and structural centrosome abnormalities are detected in various human malignancies and have been implicated in the formation of multipolar mitoses , chromosome missegregation , and chromosomal instability . despite this association between centrosome abnormalities and cancerous growth , a causative role of ce... |
today , growing public concern regarding caloric and fat intake has raised the demand for low- or reduced - fat foods [ 1 , 2 ] .
yogurt , a traditional dairy product produced by bacterial fermentation of milk with a starter culture containing streptococcus salivarius ssp .
bulgaricus , has been very popular for it... | untargeted detection of protein adulteration in chinese yogurt was performed using near - infrared ( nir ) spectroscopy and chemometrics class modelling techniques .
sixty yogurt samples were prepared with pure and fresh milk from local market , and 197 adulterated yogurt samples were prepared by blending the pure yo... |
drug - induced liver injury ( dili ) is defined as a liver injury due to xenobiotics , herbs , or medications that leads to either liver dysfunction or abnormal liver serology , in the setting of no other identifiable cause . unlike idiosyncratic drug induced liver injury ( idili ) , dili seems to be dose - dependent ,... | drug - induced liver injury ( dili ) has been linked to more than 1,000 medications and remains the most common cause of acute liver failure in the united states . here , we review the most current literature regarding treatment and make recommendations for the management of this relatively common disease .
since tre... |
balanced general anesthesia comprises amnesia , analgesia , hypnosis , muscle relaxation , and obtundation of reflexes . to achieve all these components , we use different combinations of drugs .
however muscle relaxants may confound our evaluation of depth of anesthesia due to lack of motor activity and may make the... | background and aims : intravenous agents such as propofol are commonly used to maintain adequate depth of anesthesia .
dexmedetomidine which has an anesthetic sparing effect is being considered for maintaining intraoperative depth of anesthesia .
we hypothesized to compare the effect of dexmedetomidine on depth of ... |
nephrotic syndrome ( ns ) is an illness consisting in leakage of proteins in urine , resulting in life threatening conditions due hypovolemia , hypercoagulation , and infection .
the annual incidence of ns in children in the usa and in europe has been estimated to be 17 per 100,000 children , with a cumulative preval... | idiopathic nephrotic syndrome ( ins ) is the most frequent form of ns in children .
ins is defined by the association of the clinical features of ns with renal biopsy findings of minimal changes , focal segmental glomerulosclerosis ( fsgs ) , or mesangial proliferation ( mp ) on light microscopy and effacement of foo... |
the authenticity and true status of tobacco use , especially in the form of smoking among the patient clientele is always a matter of concern for their physicians .
assessing a true status of smoking is important for physicians in regards to initiation , maintenance and successful completion of smoking cessations pro... | background : the authenticity and true status of tobacco use , especially in the form of smoking among the patient clientele is always a matter of concern for their physicians.objectives:the purpose of this study was to assess the authenticity of self - reported habit of tobacco smoking among a population sample of mal... |
iran , which is located in southwest asia , located in an epidemiologic transition and faces the double burden of diseases .
breast cancer is the most common cancer in iranian women ; meanwhile the iranian patients are relatively young . given that iran has a female population of about 38 million , this corresponds t... | backgroundbreast cancer ( bc ) is the most common cancer in iranian women , meanwhile the iranian patients are relatively young .
granzyme h ( gzmh ) is a functional cytotoxic serine protease of nk cell granules , which expands the cell death - inducing repertoire of innate immune system .
gzmh is constitutively an... |
patients with internal derangement ( i d ) and osteoarthritis ( oa ) of the temporomandibular joint ( tmj ) primarily undergo serial non - surgical treatfment , including physiotherapy , occlusal splint therapy , and medication , to relieve functional tmj pain.1,2 however , surgical procedures are sometimes required if... | this case report describes the orthodontic treatment performed for open bite caused by internal derangement ( i d ) and osteoarthritis ( oa ) of the temporomandibular joint ( tmj ) .
a japanese woman , aged 31 years and 11 months , referred to our department by an oral surgeon had an open bite with clockwise rotation... |
the asymptomatic elevation of liver enzymes is a common problem , and , if it goes undetected , it can damage the liver over time ( 1 ) . in a survey of 1959
blood donors in iran , 5.1% had asymptomatic elevated liver enzymes , and the common diagnoses for half of those affected were nonalcoholic steatohepatitis ( na... | background : hepatitis g virus ( hgv ) is a hepatotrope virus with unknown importance . the genome of the virus has been detected in patients with acute or chronic non - a - e hepatitis , cirrhosis , and hepatocellular carcinoma .
the aim of this study was to determine the association between hepatitis g and unknown ... |
increased morbidity from diabetes , hypertension , cardiovascular disease , and inflammatory disorders is common in developing and developed countries [ 2 , 3 ] .
more than one - quarter of health care costs related to obesity and associated disorders . promoting weight loss ,
decreasing body fat , maintenance of n... | a single center , open - label , dose - finding adaptive study was conducted in twelve healthy overweight female subjects .
the study was to evaluate the safety and tolerability of the capsaicinoids ( caps ) from capsicum extract in a beadlet form compared to placebo in a healthy overweight population .
the investi... |
in the past years , bcl-2 , the mammalian homologue of ced-9 , the antiapoptotic gene initially described in caenorhabditis elegans , has emerged as a major checkpoint controlling the escape of cells from their death fate ( kroemer 1997 ) . in mammals , bcl-2 is a member of a broad family of related gene products , wit... | the mechanism of action of the oncogene bcl-2 , a key regulator of the apoptotic process , is still debated .
we have employed organelle - targeted chimeras of the ca2 + -sensitive photoprotein , aequorin , to investigate in detail the effect of bcl-2 overexpression on intracellular ca2 + homeostasis . in the er and ... |
the hospitalization rates and the social impact of diverticular disease in western countries have drastically increased .
it is estimated that > 1 of 4 european citizens is affected by diverticula of the colon and therefore could potentially develop advanced clinical disorders associated with this condition .
acute... | background and objectives : to analyze the short- and long - term outcomes of laparoscopic sigmoid colectomy for the elective treatment of diverticular disease.methods:a consecutive unselected series of 94 patients undergoing elective laparoscopic sigmoid colectomy for diverticular disease from 2008 to 2012 was analyze... |
multidrug resistance
( mdr ) of cancer constitutes a significant
challenge to clinical oncology and serves as one of the major reasons
for tumor recurrence .
cancer stem cells ( cscs ) were discovered in
various types of cancer , including breast , colon , colorectal , lung , glioma , and pancreatic cancers .... | salinomycin
( sali ) has selective toxicity to cancer stem cells
( cscs ) , a subpopulation of cancer cells that have been recently linked
with tumor multidrug resistance ( mdr ) . to utilize its selective toxicity
for cancer therapy
, we sought to devise a nanoparticle ( np ) carrier
to deliver sali to sol... |
febrile seizure is the most common seizure disorder in childhood.12 its cumulative incidence is approximately 3% , but it is quite varied in nigeria with values ranging from 10 - 18%.17 the international league against epilepsy ( ilae ) defines febrile seizure as a seizure occurring in childhood after one month of age ... | background : febrile seizure is the most common seizure of childhood and has a good prognosis .
however its presentation is fraught with poor management , with grave consequences , in our environment .
thus a review of its current status is important.objective:to review the status of febrile seizures in kaduna metr... |
ostriches provide dietetic meat , valuable skin , feathers and eggs [ 3 , 4 , 27 ] that make them important alternative livestock in many parts of the world [ 57 , 13 , 22 , 23 ] . however , one of the basic reasons for the hindered development of this new agricultural activity is its low reproduction rate [ 2 , 14 , 1... | the aim of the current study was to search for genetic markers , microsatellite loci associated with laying performance in ostriches .
the material consisted of two groups of ostrich hens characterized by high or low laying performance ( over 75 and less than 25 eggs per season , respectively ) .
the investigation ... |
prostate cancer is the most diagnosed male malignancy and the second leading cause of cancer - related death among american men .
fortunately , mortality rates have increased less than incidence rates in many countries . in brazil , according to the national cancer institute , prostate carcinoma ( pca ) is the second... | lectins , proteins which selectively recognize carbohydrates , have been used in histochemistry for the evaluation of changes in glycosylation in processes of cellular differentiation and/or dedifferentiation .
cratylia mollis seed lectins ( cramoll 1,4 and cramoll 3 ) , conjugated to horseradish peroxidase , were us... |
approximately 150,000 new cases will be diagnosed in the united states in 2008 and approximately 50,000 deaths will be attributed to the disease this year .
most patients are diagnosed with colorectal cancer in the sixth and seventh decade of life .
approximately 30% of colorectal cancers occur in the sigmoid , 25%... | abstractcolorectal cancer is a common malignancy that afflicts many in the western world .
imaging studies are frequently used to evaluate patients in the screening , staging and surveillance of colorectal cancer .
cross sectional imaging studies such as ultrasound , computed tomography and magnetic resonance imagi... |
the exercise of metal / metal oxide nanoparticles as a frontier between the homogeneous catalysis and heterogeneous catalysis in organic synthesis has invoked tremendous interests in the recent times . the interesting features inherited with these small particle sizes are their large surface area along with more ed... | a feasible nose ( nanoparticles - catalyzed organic synthesis enhancement ) protocol has been developed for n , n - diformylation of bisuracil derivatives using nano - al2o3 rods as an efficient , inexpensive , and recyclable catalyst under solvent - free reaction condition at 40c .
the catalyst was reused up to th... |
molecular studies have reported that up to 15% of sporadic colorectal cancers and approximately 90% of syndrome of hereditarynon - polyposis colorectal cancer ( hnpcc ) , which accounts for 1 to 3 percent of all colorectal cancers , were caused by inactivation of mismatch repair ( mmr ) genes , such as msh2 , mlh1 , pm... | purposealthough the incidence of microsatellite instability ( msi ) accounts for 10 - 15% of cases of colorectal cancer , its clinical application for all colorectal cancers has widened .
we attempted to identify clinical and pathological parameters that may be helpful in selection of patients with msi - high ( msi -... |
talc deposits include asbestos minerals such as chrysotile and amphiboles that may be carried over into consumer products .
optical microscopy and x - ray diffraction analyses may not reveal their presence .
examples are given of electron microscopy procedures that permit detection and measurement .
imagesfigure ... | |
self - care was introduced by orem as one of the components of self - care nursing theory .
orem recognizes human and environment as a single unit and believes that human and environment , and also humans themselves , influence each other reciprocally in this unit .
beliefs , social and cultural background , person... | background : hepatitis is an inflammatory disease which has many adverse effects on patients life because of its chronic nature . since orem 's theory of self - care is a grounded theory , the concepts and applications of this theory in patients with chronic hepatitis who have special needs may lead to some challenges ... |
pyelonephritis is a serious infection of the upper urinary tract ( the kidneys and ureters ) that often requires hospitalization .
patients with pyelonephritis often have chills that start suddenly , fever , and pain between the ribs and hips on one or both sides of the body . based on these symptoms
computed tomog... | purposepyelonephritis , an upper urinary tract infection , is a serious infection that often requires hospitalization .
however , the accurate diagnosis of acute pyelonephritis can be difficult , especially among older individuals who can present with unusual symptoms .
imaging with computed tomography ( ct ) is no... |
chemical modification of these compounds have led to a large number of mono- and di - s and n - substituted analogs showing therapeutic properties , especially antivirial , antithyroid , and antitumor activities [ 17 ] .
the antimetabolites of 5,6-dimethyluracil 5-morpholinomethyl-6-methyl-2-thiouracil and 5-piperi... | six new 2-o-(m- and p-)chlorobenzylthio-6-methyl-5-piperidino-(or morpholino- ) methyluracils have been prepared .
the structures of these compounds were confirmed by spectroscopic ( ft - ir , uv - vis , 1h nmr , 13c nmr , and hmbc ) and elemental analyses .
estimation of pharmacotherapeutic potential has been made... |
urticarial vasculitis is characterized by recurrent episodes of urticaria with biopsy evidence of leukocytoclastic vasculitis ( 1 ) .
although urticarial vasculitis is frequently idiopathic , it has been reported to be associated with infection , malignancy , certain drugs , and connective tissue diseases such as sys... | urticarial vasculitis is characterized clinically by urticarial skin lesions and histologically by leukocytoclastic vasculitis .
hypocomplementemic urticarial vasculitis is associated with connective tissue diseases such as systemic lupus erythematosus ( sle ) .
we report a case of urticarial vasculitis that preced... |
the sessions take place 5 days per week with a duration of 1hour delivering 600 contractions .
this is how we deliver the paradigm : basically , the rats are restrained in a plastic tube , in which they are free to move .
you can actually see what these contractions here look like once every 6 seconds .
so , her... | electrical muscle stimulation following peripheral nerve injury has been a controversial method of treatment due primarily to the inconsistent literature surrounding it . in this presentation transcript
i outline ongoing experiments investigating a clinically translatable daily muscle stimulation paradigm in rats fol... |
when skeletal muscle fibers are excited , a cascade of events is triggered , which ultimately leads to forces exerted on the skeleton .
muscle forces are needed for movements , such as locomotion , and the maintenance of body balance .
there are many structures involved at several levels organization : from actin ,... | the classic view of skeletal muscle is that force is generated within its muscle fibers and then directly transmitted in - series , usually via tendon , onto the skeleton .
in contrast , recent results suggest that muscles are mechanically connected to surrounding structures and can not be considered as independent a... |
type 1 diabetes patients often suffer from total loss of their functional cells , as indicated by the complete absence of insulin c - peptide in their serum .
replacing cell mass by pancreatic islet transplantation has been shown to be curative in principle but is limited by the availability of donor islets , immun... | summarytype 1 diabetes is characterized by the destruction of pancreatic cells , and generating new insulin - producing cells from other cell types is a major aim of regenerative medicine .
one promising approach is transdifferentiation of developmentally related pancreatic cell types , including glucagon - produci... |
99mtc pertechnetate scintigraphy is routinely used to detect testicular torsion and differentiate this condition from acute epididymo - orchitis .
however , differentiation of torsion from hydrocele and testicular or scrotal abscess may be difficult . in this report ,
we present a 5-year old child in whom epididymi... | scintigraphic differentiation between acute torsion , hydrocele and testicular or scrotal abscess can be difficult .
doppler sonography may provide useful complimentary information toward diagnosis .
the authors describe a 5-year - old child where epididymitis with hydrocele was misdiagnosed as testicular torsion o... |
polycystic ovary syndrome ( pcos ) is characterized by oligo - anovulation , clinical or biochemical hyperandrogenism and/or polycystic ovaries ( franks , 1995 ; knochenhauer et al . , 1998 ; fauser , 2004 ) .
insulin resistance ( ir ) accompanied by compensatory hyperinsulinaemia constitutes another major biochemica... | backgroundan rct among newly diagnosed , therapy naive women with polycystic ovary syndrome ( pcos ) showed no significant differences in ovulation rate , ongoing pregnancy rate or spontaneous abortion rate in favour of clomifene citrate plus metformin compared with clomifene citrate .
we wanted to assess whether the... |
the lipid benzoquinone sorgoleone ( 2-hydroxy-5-methoxy-3-[(8z , 11z)-8 , 11 , 14-pentadecatriene]-p - benzoquinone ) is a potent allelochemical that is produced as an oily exudate from the root hairs of sorghum ( sorghum bicolor ) ( czarnota et al.2001 ; dayan et al.2007 ) , along with a variety of structural analogue... | this study investigated the roles of jasmonates in the regulation of sorgoleone accumulation and the expression of genes involved in sorgoleone biosynthesis in sorghum roots . both methyl jasmonate ( meja ) and jasmonic acid ( ja ) substantially promoted root hair formation , secondary root development , root weight , ... |
human nature is uniquely characterized by the flexibility , complexity , and sophistication with which thought and behavior can be deployed in the service of a goal . this ability is thought to depend on cognitive control , a collection of mechanisms , including perceptual selection , response biasing , and online main... | it is becoming increasingly appreciated that affective influences can contribute strongly to goal - oriented cognition and behavior . however , much work is still needed to properly characterize these influences and the mechanisms by which they contribute to cognitive processing .
an important question concerns the n... |
glucocorticosteroids have been used in an attempt to minimize or prevent post - operative edema after oral and maxillofacial surgery .
dexamethasone seems to be the most suitable because it has the highest anti - inflammatory activity , no mineralocorticoid activity and a longest available half - life of 36 - 54 h. p... | a broad array of behavioral symptoms , including psychosis , can transpire post - operatively following a variety of surgeries .
it is difficult to diagnose the exact cause of post - operative psychosis .
we report three cases , which developed psychosis post - operatively after undergoing major oral and maxillofac... |
haemophilus influenzae type b ( hib ) is responsible for most cases of invasive h. influenzae disease , including meningitis and septicemia , in unvaccinated children . with the decline in the incidence of invasive hib disease as a result of the hib vaccine program ,
nontypeable h. influenzae ( nthi ) has become an i... | nontypeable haemophilus influenzae ( nthi ) commonly colonizes the upper respiratory tract of children and causes otitis media , sinusitis , and bronchitis .
invasive nthi diseases such as meningitis and septicemia have rarely been reported , especially in children with underlying predisposing conditions such as head... |
diabetes mellitus is a major cause of erectile dysfunction ( ed ) , and the prevalence of ed is more common and the symptoms of ed occur earlier in diabetic men than in the general population .
the suggested mechanisms for diabetic ed include damage to the cavernous endothelial and smooth muscle cells at both structu... | purposeendothelial dysfunction and peripheral neuropathy are important mechanisms responsible for diabetes - induced erectile dysfunction ( ed ) .
nerve injury - induced protein 1 ( ninjurin 1 ) is known to be related to neuroinflammatory processes and is also reported to induce vascular regression during the develop... |
indeed , the common pathological feature of chronic inflammation ( e.g. , chronic colitis ) and solid cancer involves a massive infiltration of immune cells into the sites .
the pathological changes in solid cancers include recruitment and modifying of various types of dysregulated immune cells and endothelial cells ... | development of solid cancer depends on escape from host immunosurveillance .
various types of immune cells contribute to tumor - induced immune suppression , including tumor associated macrophages , regulatory t cells , type 2 nkt cells , and myeloid - derived suppressor cells ( mdscs ) .
growing body of evidences ... |
a 49-year - old woman presented with breathlessness on exertion with gradual onset over the previous one month ; there was no other significant past medical history .
cardiac and respiratory examinations were normal , and the 12-lead electrocardiogram ( ecg ) was inconspicuous .
two - dimensional echocardiography s... | anomalous origin of the left coronary artery from the pulmonary artery ( alcapa ) is an extremely rare , potentially fatal , congenital anomaly with a high mortality rate in the first year of life .
it occurs rarely in adulthood and may appear with malignant ventricular a rrhythmia or sudden death .
we report a cas... |
nemazee had been studying the deletion of autoreactive b cells in transgenic mice whose b cells all expressed receptors specific for a particular mhc molecule . when this transgene was bred onto mice that expressed that mhc protein ,
as expected , these mice lacked autoreactive b cells in the periphery . but to nemaz... | in 1993 , david nemazee and martin weigert independently showed that autoreactive b cells could proofread , alter , and reexpress modified receptors to become nonautoreactive .
this process , called receptor editing , has since gained prominence as the main mechanism of b cell tolerance . |
iron deficiency , the common cause of anemia , underlies 115,000 maternal deaths worldwide per year.1 iron is a major constituent of hemoglobin , the oxygen - carrying pigment of the red blood cells .
its level varies with different trimesters of pregnancy , and this , in turn , is a function of the net effect of abs... | backgroundlow serum ferritin levels signify low iron stores and this could predispose to iron deficiency anemia.objectiveto determine the rate and predictors of low serum ferritin levels during the puerperium in enugu , southeast nigeria.study designa hospital - based prospective longitudinal study involving parturient... |
peroxisome proliferator activator receptor gamma ( ppar ) is a member of the nuclear receptor superfamily and is a ligand - activated transcription factor that regulates genes responsible for some very important biological functions including : cell growth , differentiation and metabolism and acts as dietary lipid sens... | background : peroxisome proliferator activator receptor gamma ( ppar ) is a nuclear transcription factor regulating multiple genes involved in cell growth , differentiation , carbohydrate and lipid metabolism and energy production . several genetic variations in the ppar gene have been identified to be associated with ... |
over the past few years ,
semiconductor nanowires ( nws ) have become
a large research field due to their interesting electrical and optical
properties due to quantum effects , large surface to volume ratio ,
and capability for bottom - up assembly .
nw - based memory devices , lasers , single - molecule sens... | iii v nanowires ( nws ) grown
with metal organic chemical
vapor deposition commonly show a polytypic crystal structure , allowing
growth of structures not found in the bulk counterpart . in this paper
we studied the radial overgrowth of pure wurtzite ( wz ) gaas nanowires
and characterized the samples with ... |
vasospasm ( vsp ) is one of the major causes for prolonged neurologic deficit in patients with aneurysmal subarachnoid hemorrhage.1 treatment of vsp is therefore one of the main priorities for these patients .
balloon angioplasty or stenting are options for vsp of the proximal vessels , whereas distally located vsp i... | vasospasm ( vsp ) is one of the major causes for prolonged neurologic deficit in patients with aneurysmal subarachnoid hemorrhage .
few case series have reported about continuous local intra - arterial nimodipine administration ( clina ) in refractory vsp .
we report our experience with clina in a patient with refr... |
about 2 to 3 of every 1000 children are identified with hearing loss at birth each year in the united states , and hearing impairment is , in fact , the most common sensory deficit in the pediatric population [ 14 ] . late - onset hearing loss or acquired hearing loss , in addition to congenital hearing loss , is preva... | objectives . to review
our experience of conducting auditory brainstem
response ( abr ) test on children in the operating room
and discuss the benefits versus limitations of this
practice . methods .
retrospective
review study conducted in a pediat... |
the german pathologist rudolph virchow was probably the first to describe the histologic features of myxofibroma in 1863 , although the lesions of jaws were not particularly mentioned . in 1947 ,
odontogenic myxoma is an uncommon benign mesenchymal odontogenic tumor arising from the dental papilla , follicle , or the... | odontogenic tumors represents a broad spectrum of lesions ranging from benign to malignant to dental hamartomas all arising from odontogenic residues , that is , the odontogenic epithelium , ectomesenchyme with variable amounts of dental hard tissues formed in the same sequence as in normal tooth development .
we rep... |
they prevent the establishment of potentially harmful pathogens and assist in improving the immune system . on the other hand
, the microbiota may promote the development of allergic diseases and is a major reservoir for endogenous infections . for bacteria in the nasal habitat ,
the latter has mainly been demonstr... | the nares represent an important bacterial reservoir for endogenous infections . this study aimed to assess the prevalence of nasal colonization by different important pathogens , the associated antimicrobial susceptibility and risk factors .
we performed a prospective cohort study among 1878 nonhospitalized voluntee... |
geolocation and remote sensing technologies are increasingly being applied to the mapping and spatial analysis of infectious diseases , including lymphatic filariasis and malaria . for such maps to reflect the real pattern of infection or disease ,
lymphatic filariasis and malaria are both currently subject to rene... | the spatial variation of wuchereria bancrofti and plasmodium falciparum infection densities was measured in a rural area of papua new guinea where they share anopheline vectors .
the spatial correlation of w. bancrofti was found to reduce by half over an estimated distance of 1.7 km , much smaller than the 50 km grid... |
there has been a lot of debate not only about how dcsg sorting occurs but also about exactly where in the cell this triage takes place .
all cells have the capacity to rapidly secrete proteins after their transit through the constitutive secretory pathway .
a great deal of evidence supports the view that in the app... | the intracellular sorting of peptide hormone precursors to the dense core secretory granules ( dcsgs ) is essential for their bioactivation . despite the fundamental importance of this cellular process
, the nature of the sorting signals for entry of proteins into dcsgs remains a source of vigorous debate .
this re... |
four months before , the patient had developed cardiogenic shock while attempting stent insertion ( endeavor 3.0~18 ) into the obstructed left main coronary artery ( 80% ) , which necessitated urgent institution of extracorporeal membrane oxygenation ( ecmo ) and intra - aortic balloon pump . after coming off extracorp... | indication for extracorporeal membrane oxygenation ( ecmo ) has been extended as the experience of ecmo in various clinical settings accumulates and the outcome after ecmo installation improves .
we report two cases of successful mitral valve surgery for severe ischemic mitral regurgitation in patients on ecmo suppor... |
the morbidity of breast cancer is gradually increasing , and a growing number of young people are now at risk for this disease . in china ,
breast cancer continues to be the leading cause of death among women . with the improvement in diagnosis and development of drugs and radiotherapy technology
. therefore , earl... | backgroundthis study aimed to investigate the expression and significance of 5 types of mirnas in breast cancer to provide a theoretical and practical foundation for using these mirnas in the diagnosis and treatment of breast cancer , thereby improving medical services.material/methodsstem-loop real - time rt - pcr was... |
trypanosoma cruzi is an intracellular protozoan parasite causing chagas disease , which affects millions of people in latin america . during the acute inflammatory phase of the t. cruzi infection , high - level expression of inducible nitric oxide synthase
( inos ) , proinflammatory cytokines , and arachidonic acid- ... | the intracellular protozoan parasite trypanosoma cruzi causes chagas disease , a serious disorder that affects millions of people in latin america .
cell invasion by t. cruzi and its intracellular replication are essential to the parasite 's life cycle and for the development of chagas disease . here
, we present e... |
to describe a patient with intrachoroidal cavitation in the normal eye that caused self - limiting recurrent macular detachment and retinoschisis .
an 80-year - old female patient with intrachoroidal cavitation in the normal eye presented with macular detachment and retinoschisis after cataract surgery .
one year a... | purposeto describe a patient with intrachoroidal cavitation in the normal eye that caused self - limiting recurrent macular detachment and retinoschisis.case reportan 80-year - old female patient with intrachoroidal cavitation in the normal eye presented with macular detachment and retinoschisis after cataract surgery ... |
traditionally , the neisseria species has two potential pathogenic strains ; neisseria meningitidis and neisseria gonorrhoeae . the remainder of neisseria species , including neisseria mucosa , are considered normal flora colonizing the respiratory tract , living in symbiosis .
one analysis showed that the majority o... | peritonitis is a leading complication of chronic ambulatory peritoneal dialysis . however , very rarely does neisseria mucosa cause peritonitis .
we describe an unusual case of n. mucosa peritonitis in a chronic ambulatory peritoneal dialysis patient . a 28-year - old hispanic male presents with diffuse abdominal pai... |
good quality water is gradually getting beyond the reach of average households in developing countries .
this is attributed to low income earnings vis - - vis the ever increasing cost of other sources of energy for water disinfectant such as kerosene and firewood .
the use of chloride solution concentrate has been... | a box - type solar heater was designed , constructed , and used to determine the effect of solar heating on quality of domestic roof - harvested rainwater ( drhrw ) . during testing ,
naturally contaminated drhrw was harvested in ibadan , nigeria , and released into the system at 93.96 lh1 ( 2.61 105 m3 s1 ) in a... |
cells continuously encounter a wide variety of intrinsic and extrinsic stresses that damage the integrity of dna ( lindahl and barnes , 2000 ) .
mitochondrial respiratory chain generates reactive oxygen species ( ros ) , which are the most prevalent intrinsic source of dna damage .
extrinsic sources of dna damage a... | error - free replication and repair of dna are pivotal to organisms for faithful transmission of their genetic information .
cells orchestrate complex signaling networks that sense and resolve dna damage .
post - translational protein modifications by ubiquitin and ubiquitin - like proteins , including sumo and ned... |
duodenal atresia and stenosis are rare causes of intestinal obstruction in the newborn , with a prevalence of 1 in 5,000 to 10,000 live births , with duodenal stenosis occurring less frequently than duodenal atresia.1 however , these intestinal tract anomalies occur significantly more frequently in patients with down s... | duodenal stenosis and duodenal atresia are well - known gastrointestinal anomalies in patients with down syndrome .
although duodenal atresia presents early and classically with vomiting in the immediate neonatal period , the presentation of duodenal stenosis can be significantly more subtle and the diagnosis delayed... |
as the population ages , interest in maintaining and improving older adults psychological well - being as an important indicator of quality of life , has received substantial scholarly attention in gerontological research . in light of this consideration ,
several scientific investigations have been conducted to find... | backgroundthere is a growing body of literature indicating that attitudes toward aging significantly affect older adults psychological well - being .
however , there is a paucity of scientific investigations examining the role of older adults attitudes toward aging on their spouses psychological well - being .
ther... |
different individuals use different strategies for coping with negative affective state and associated life problems .
such coping mechanisms are important both in periods of acute stress / emergencies ( such as hurricane disasters ) as well as in patients suffering from chronic illnesses such as depression , breast ... | different individuals use different coping styles to cope with their problems . in patients with anxiety and/or depression ,
these have important implications .
the primary objective of our study was to estimate the frequency of different coping mechanisms used by patients with symptoms of anxiety and depression . ... |
pneumonia is the second cause of hospital acquired infections after catheter site infection that leads to prolonged hospital stays , increased morbidities and higher expenses[1 , 2 ] .
ventilator associated pneumonia ( vap ) is the most common kind ( 86% ) of hospital acquired pneumonia . according to cdc definitions... | objectiverecent data suggest that during mechanical ventilation , lateral patient position ( in which the endotracheal tube is horizontal ) decreases the incidence of bacterial colonization of ventilated neonates .
the objective of this study was to evaluate the influence of lateral and supine position on bacterial c... |
lupus nephritis ( ln ) is a major clinical manifestation of systemic lupus erythematosus ( sle ) ; it occurs in up to 50% of patients at onset of the disease and over 60% of patients during the disease .
clinical course ranges from asymptomatic urinary occult blood to nephrotic syndrome or acute kidney injury since k... | lupus nephritis ( ln )
is a major clinical manifestation of systemic
lupus erythematosus ( sle ) .
although numerous
abnormalities of immune system have been
proposed , cytokine overexpression plays an
essential role i... |
when infant rhesus monkeys were exposed to lead via the addition of lead acetate ( 0.59 mg / kg body weight ) to their formula or by the consumption of lead particles from lead - based surrogate mothers , they developed symptoms of lead intoxication within 6 weeks .
seizures , muscular tremors , and altered social in... | |
the database of the korea university anam hospital , seoul , korea was searched for all crc patients who underwent surgical resection between 2002 and 2013 .
a cohort of patients who underwent hepatic resection or pulmonary resection for crc metastases was also identified .
sections were incubated for 15 minutes wi... | backgroundcolorectal cancer ( crc ) is one of the most common malignancies worldwide .
approximately 10%15% of the crc cases have defective dna mismatch repair ( mmr ) genes .
although the high level of microsatellite instability status is a predictor of favorable outcome in primary crc , little is known about its ... |
refractive accommodative esotropia ( rae ) is an esotropia that is restored to orthotropia at all fixation distances and all gaze positions by optical correction of the underlying hypermetropic refractive error .
retinal image blur induces accommodation to focus the image ; then , this accommodative effort elicits ac... | purpose . to investigate the psychophysiologic aspects of refractive accommodative esotropia ( rae ) .
methods .
i prospectively recruited patients aged 36 years with more than 3.0 diopters of hyperopia who presented at kim 's eye hospital from january 2011 to march 2013 .
i compared korean child behavior checkli... |
the management of unowned domestic cat ( felis catus ) populations is a global problem that raises issues for individual cat welfare and conservation of native wildlife .
the remarkable reproductive success of this species is a major factor in the ability of cats to colonise diverse environments .
the onset of pube... | objectivesthe aim of the study was to investigate the effects of age and/or surgical approach on perioperative wound complication following ovariohysterectomy ( ohe).methodsa retrospective search of perioperative monitoring records from a shelter desexing program was conducted to identify cats that underwent ohe betwee... |
osteoporosis and hip and vertebral osteoporotic fractures among an ageing population are a worldwide health problem that lead to a decreased quality of life ( 1 ) .
body weight and body mass index ( bmi ) are considered potentially modifiable determinants of bone mass ( 2 , 3 ) .
several studies have demonstrated a... | background and objective : body weight and body mass index ( bmi ) are considered potentially modifiable determinants of bone mass .
therefore , the aim of this study was to explore the association between body weight and body mass index ( bmi ) with total hip and lumbar spine bone mineral density ( bmd).methods : th... |
principal neurons of the ca1 region receive input from the entorhinal cortex ( ec ) via two pathways : ( i ) the direct temperoammonic ( ta ) pathway , which consists of afferents from layer iii of ec and forms synapses with ca1 neurons in the stratum lacunosum moleculare ; and ( ii ) the indirect pathway , which origi... | nmda receptors are composed of multiple subunits and are crucial in the induction of synaptic plasticity and learning and memory . in this study ,
application of the group i mglu receptor agonist , dhpg , caused ltd of nmda - epscs ( dhpg - ltdnmda ) of the schaffer collateral , but not of nmda - epscs of the tempero... |
among stage iiia non - small cell lung cancer patients , t4n0 - 1 cases can be good candidates for surgery and have a relatively favorable postoperative prognosis [ 1 , 2 ] .
however , most t4 cases with thoracic vertebral invasion may not be operated as complete resection with vertebrectomy is challenging .
we rep... | we present a case who had left upper lobectomy with total vertebrectomy after arterial embolization in preparation for intraoperative bleeding . a 35-year - old man complained of left back pain .
chest ct revealed a tumor in s1 + 2 of the left lung , invading the third thoracic vertebra .
as no nodal or distant met... |
the mouse b lymphocyte cell lines wehi-231 expressing shrna construct control ( wehi - ct ) or a shrna construct directed against the transcription factor tfii - i ( wehi - tkii - i - kd ) were used to investigate the effect of tfii - i depletion on global gene expression and ctcf binding . to identify genes regulat... | ctcf is a key regulator of nuclear chromatin structure , chromatin organization and gene regulation .
the impact of ctcf on transcriptional output is quite varied , ranging from repression , to transcriptional pausing and transactivation .
the multifunctional nature of ctcf is mediated , in part , through different... |
the most common disorders of consciousness include vegetative state ( vs ) and minimally conscious state ( mcs ) .
patients in mcs show weak but definite self - awareness or environmental awareness , and some patients have spontaneous eye opening and sleep wake cycles .
although the patient s cognitive behaviors a... | to observe changes in mismatch negativity ( mmn ) and p300 in a patient transitioning from a vegetative state ( vs ) to a minimally conscious state ( mcs ) .
one patient with intracerebral hemorrhage and an 8-month disease course was evaluated as being in the vs using the coma recovery scale - revised .
two weeks a... |
although priapism has been reported as a complication of malignant tumor metastasis , leukemia , sickle cell disease , embolism and spinal canal stenosis [ 1 , 2 , 3 , 4 , 5 ] , there are few reports of priapism as a complication of colorectal cancer in the absence of penile metastasis . here
we report a patient with... | a 65-year - old man was admitted with penile tenderness and dysuria due to priapism . enhanced computed tomography revealed metastatic tumors in the liver , lung , sacrum and lymph nodes .
advanced rectal cancer , detected by colonoscopy as a primary tumor , was treated with chemotherapy ( folfox4 ) .
although the ... |
during a 6-year period ( 20102015 ) , there were a total of 2,310 diagnoses of pulmonary adc in our institute .
of 2,310 patients , 401 patients underwent a second biopsy or resection for recurrent or metastatic tumors . out of 401 patients , a total of six patients ( 1.5% ) with primary lung adc showed transformed s... | background : epidermal growth factor receptor ( egfr ) tyrosine kinase inhibitors ( tkis ) are considered the first line treatment for a subset of egfr - mutated non - small cell lung cancer ( nsclc ) patients .
although transformation to small cell lung cancer ( sclc ) is one of the known mechanisms of resistance to... |
small bowel volvulus is a rare but dangerous condition that can rapidly cause intestinal vascular compromise and lead to bowel ischemia and necrosis .
we present a patient who developed a small bowel volvulus around an adhesion formed between an endotack from a recent laparoscopic hernia repair and the midportion of ... | background and objectives : we present a case of small bowel volvulus around an endotack applied during total extraperitoneal laparoscopic hernia repair ( tep ) .
this complication prompts reconsideration of the role of tacks during extraperitoneal laparoscopic hernia repairs.methods:we undertook a chart review and p... |
triple - negative breast cancer ( tnbc ) accounts for approximately 15% of all breast tumors [ 1 , 2 , 3 ] .
it is characterized by a lack of expression of the estrogen receptor , progesterone receptor , and human epidermal growth factor receptor 2 ( her2 ) [ 1 , 3 ] . due to the absence of expression of these recept... | our case describes a 51-year - old female , diagnosed in april 2008 with a triple - negative , brca1-positive , infiltrating ductal carcinoma of the left breast .
initial platinum - based therapy resulted in a complete regression until november 2009 , when a recurrence of the disease was detected .
as no evidence o... |
acromegaly is a syndrome seen in adults due to excessive production of pituitary growth hormone as a result of an adenoma or hyperplasia of the eosinophilic cells of the anterior pituitary gland .
the main clinical features of acromegaly are skeletal overgrowth affecting the hands , feet , and skull along with spinal... | depression is one of the commonest disorders encountered in general hospital psychiatry .
acromegaly is a condition with excessive growth hormone secretion that may at times present with oversychopathology .
we present the case of a 33-year - old lady with depression and acromegaly that successfully resolved after ... |
diverse morphological tooth anomalies are found in various shapes , textures , and prevalence . they can be sporadic or syndromes , nutritional , environmental , genetic , and ethnic related .
most of these tooth - born deformations ( e.g. , shovel - shaped incisors , tuberculum carabelli , variations in number and s... | a 47-year - old male patient reported to the department of periodontology , with a chief complaint of pus discharge from maxillary left central incisors with dull intermittent pain . on clinical examination , a localized gingival inflammation was present with soft edematous tissue with the accumulation of plaque and ca... |
the primary function of the immune system is to protect the host from infectious microbes in its environment .
this system has evolved over millions of years , in response of coexistence with microorganisms .
basically , the system can be divided in two components , the innate and adaptive immunities .
the innate... | the transplant of organs is one of the greatest therapeutic achievements of the twentieth century . in organ transplantation
, the adaptive immunity is considered the main response exerted to the transplanted tissue , since the principal target of the immune response is the mhc ( major histocompatibility complex ) mo... |
nonduplicate , imipenem - resistant isolates of 387 pseudomonas spp . and 267 acinetobacter spp . were collected from 2000 to 2001 from 28 hospitals in the korean nationwide surveillance of antimicrobial resistance group hospitals located in six cities or provinces .
the identification of the species and the imipenem... | we determined the occurrence of acquired metallo--lactamase ( mbl)producing bacteria in korean hospitals . among the isolates
nonsusceptible to imipenem that were collected from 28 hospitals from 2000 to 2001 , 44 ( 11.4% ) of 387 pseudomonas spp .
and 38 ( 14.2% ) of 267 acinetobacter spp .
infections produced m... |
restless legs syndrome ( rls ) is a common , distressing disease that affects a significant percentage of the adult population . in the us , 2% to 3% of the population experience clinically bothersome symptoms severe enough to warrant treatment.13 rls is characterized by discomfort of the legs during rest or inactivity... | restless legs syndrome ( rls ) is a sleep - related movement disorder commonly involving an unpleasant urge to move the limbs , typically the legs .
dopaminergic agents represent the first - line therapy for rls ; however , long - term use of such drugs results in worsening symptoms due to augmentation or other adv... |
xeroderma pigmentosum ( xp ) is a rare autosomal recessive disorder characterized by cutaneous photosensitivity , pigmentary changes , photophobia and propensity to develop early malignancy in sun - exposed skin and ocular structures .
the malignancies described commonly in patients with xp include squamous cell carc... | xeroderma pigmentosum ( xp ) is a rare autosomal recessive disorder related to defective deoxyribonucleic acid ( dna ) repair .
various cutaneous manifestations related to ultraviolet ( uv ) damage characterize the clinical course .
primary malignant cutaneous neoplasms like squamous cell carcinoma , basal cell car... |
nitrogenase is a complex metalloenzyme that catalyzes the nucleotide - dependent reduction of atmospheric n2 to bioavailable nh3 .
the best - studied mo - dependent nitrogenase is a binary system consisting of the fe protein and the fe mo ( mofe ) protein .
the fe protein is an 2 homodimer containing one [ fe4s4 ]... | nifen plays a key role in the biosynthesis of the iron molybdenum cofactor ( femoco ) of nitrogenase . a scaffold protein that hosts the conversion of a femoco precursor to a mature cofactor
, nifen can assume three conformations during the process of femoco maturation .
one , designated nifb nifen , contains only... |
the first is the microbial component and the second factor is the host response to periodontopathogens , notably the over production by resident and immune cells of inflammatory mediators and matrix metalloproteinases ( mmps ) , which can modulate the progression and severity of periodontitis .
mmp enzymes are a fami... | background : this study compared the effect of adjunctive low dose doxycycline and licorice on gingival crevicular fluid ( gcf ) matrix metalloproteinase-8 ( mmp-8 ) levels in patients with chronic periodontitis.materials and methods : in this in vivo , experimental study 39 patients with mild to moderate chronic perio... |
the benefits of gnrh agonist ( gnrha ) used for controlled ovarian stimulation ( cos ) are well known .
there are two types of gnrha , the multi - low - dose ( short - acting ) or the single depot ( long - acting ) .
the currently available depot products were prepared for endometriosis or fibroids , the objective ... | objective : appropriate dosage of the long - acting depot gonadotrophin releasing hormone ( gnrh ) agonist has not been determined in long protocol for ivf , and one - third - dose depot triptorelin was compared with half - dose in a luteal long protocol of in - vitro fertilization/ intra cytoplasmic sperm injection ( ... |
the task of quantizing general relativity is one of the outstanding problems of modern theoretical physics .
attempts to reconcile quantum theory and general relativity date back to the 1930s ( see for a historical review ) , and decades of hard work have yielded an abundance of insights into quantum field theory ,... | in three spacetime dimensions , general relativity drastically simplifies , becoming a
topological theory with no propagating local degrees of freedom
. nevertheless , many of the difficult conceptual problems of quantizing gravity are still present . in this review ,
i summarize the rather large body of work th... |
based on world health organization statistics , falls are the second leading cause of unintentional injury - related deaths worldwide.1 around 424,000 people globally die every year from unintentional falls , second only to road traffic deaths .
injuries sustained from falls are unfortunately quite common in the elde... | backgroundmultifocal glasses ( bifocals , trifocals , and progressives ) increase the risk of falling in elderly people , but how they do so is unclear . to explain why glasses with progressive addition lenses increase the risk of falls and whether this can be attributed to false projection , this study aimed to 1 ) ma... |
in conclusion , we report a ketyl olefin
coupling for the
preparation of substituted 3-benzylchroman-4-ols , promoted by visible
light photoredox catalysis .
importantly , we uncovered trialkylamines
as a cheap and readily available alternative to the previously reported
electron proton donor system consi... | a visible
light photoredox - catalyzed aldehyde olefin cyclization
is reported .
the method represents a formal hydroacylation of alkenes
and alkynes and provides chromanol derivatives in good yields .
the
protocol takes advantage of the double role played by trialkylamines
( nr3 ) which act as ( i ) elec... |
various guidelines have been suggested for appropriate evaluation of metastatic cancers when the primary tumor site is not readily identifiable based on the clinical presentation , tissue histology and immunohistochemical staining .
after such evaluation , cancer of unknown primary ( cup ) is the diagnosis made in ab... | cancer of unknown primary ( cup ) is a clinical syndrome representing many types of cancers and diagnoses are typically made after review of clinical presentation , pathology ( including immunohistochemical staining ) and imaging studies .
treatment with systemic chemotherapy has been shown to result in fairly reprod... |
treatment options for hepatitis c virus ( hcv ) infection in renal transplant ( rtx ) patients are limited .
the conventional treatment of interferon ( ifn ) injection with ribavirin carries the risk of allograft rejection .
conversely , not treating for hcv is associated with increased morbidity and mortality due ... | liver disease due to hepatitis c infection in renal transplant recipients is difficult to treat and often associated with reduced patient survival .
a 43-year - old male , a renal allograft recipient , presented at 6 years follow - up with significant weight loss over 3 months .
he was detected to have new onset di... |
pancreatic endocrine tumors are classified , according to the symptomatology , in secreting and nonsecreting tumors .
the nonsecreting tumors ( silent , in hormonal terms ) represent about 50% of the total ; they are followed by insulinomas - 25% and gastrinomas - 15% .
it may be associated with other endocrine gla... | insulinoma is a rare pancreatic islet cell tumor , the most common cause of hypoglycemia related to endogenous hyperinsulinism .
we present the case of an adult patient with pancreatic insulinoma .
the patient presented to our clinic after prior hospitalizations in diabetes and psychiatry hospital units for repeate... |
we are born in organizations , educated by organizations , and most of us spend much of our lives working for organizations .
we spend much of our leisure time paying , playing , and praying in organizations .
most of us will die in an organization , and when the time comes for burial , the largest organization of ... | objectivethe purpose of this article is to present select concepts and theories of bureaucratic structures and functions so that chiropractic physicians and other health care professionals can use them in their respective practices .
the society - culture - personality model can be applied as an organizational instru... |
already in 1949 hebb proposed that simultaneous neuronal firing stimulates synaptic plasticity . later several studies found evidence for experience - dependent neurogenesis in the hippocampi of adult mice ( for a review see ) .
today there is accumulating evidence that also the human brain continues to be shaped by ... | this study investigated the impact of life kinetik training on brain plasticity in terms of an increased functional connectivity during resting - state functional magnetic resonance imaging ( rs - fmri ) .
the training is an integrated multimodal training that combines motor and cognitive aspects and challenges the... |
in today 's world with high speed collision , number of patients with complex trauma injuries has increased .
these patients present with unique challenges as several injuries may require contrasting physiological management . patients with traumatic brain injury ( tbi ) require maintenance of vital parameters within... | with an ever - increasing incidence of high impact collisions , polytrauma is becoming increasingly common .
patients with traumatic brain injury ( tbi ) may require urgent surgical intervention along with maintenance of an adequate mean arterial pressure ( map ) to maintain cerebral perfusion .
on the other hand ,... |
dentine hypersensitivity ( dh ) is an abnormal response of the exposed vital dentine to thermal , chemical , or tactile stimuli .
the prevalence of dh has been reported ranging from 4 to 57% in many studies in the literature , depending on the population samples studied [ 1 , 2 ] . in patients affected by periodontit... | introduction . dentine hypersensitivity ( dh ) is characterized by pain after stimuli that usually provoke no symptoms .
this study compared the effectiveness of gaalas diode laser alone and with topical sodium fluoride gel ( naf ) .
materials and methods .
the study was conducted on 10 patients ( 8 f/2 m , age 2... |
the superfamily of
cytochrome p450 enzymes ( cyps ) is one of the
most versatile biocatalyst systems in nature .
cyps are capable
of catalyzing more than 20 distinct types of reactions including regio-
and stereoselective oxidation of unactivated c
h bonds ( hydroxylation
and epoxidation ) , dealkylation ... | cytochrome
p450 enzymes are capable of catalyzing a great variety
of synthetically useful reactions such as selective c h functionalization .
surrogate redox partners are widely used for reconstitution of p450
activity based on the assumption that the choice of these auxiliary
proteins or their mode of actio... |
climate change impacts are being observed worldwide on human and natural systems , including water resources , forestry , food production , coastal areas , ecosystems , industry , settlements and human health ( intergovernmental panel on climate change ( ipcc ) 2007 ; stern 2006 ) .
many recent publications have high... | objectiveit is now recognized that climate change affects human health .
the question is how to adapt .
this article examines mainstreaming climate considerations into public health programs and the utility of climate change and health adaptation frameworks , using ontario , canada , as a case study.methodsa litera... |
alcoholic steatohepatitis ( ash ) represents the intermediate stage of liver injury in the progression of steatosis , inflammation , and hepatocellular apoptosis and necrosis that occurs in the development of alcoholic cirrhosis .
this paper will address the role of ethanol - induced aberrant hepatic methionine metab... | the pathogenesis of alcoholic steatohepatitis ( ash ) involves ethanol - induced aberrations in hepatic methionine metabolism that decrease levels of s - adenosylmethionine ( sam ) , a compound which regulates the synthesis of the antioxidant glutathione and is the principal methyl donor in the epigenetic regulation of... |
. introduced
through the active ingredient , excipients , or the atmosphere , it can
induce phase transitions , dissolve soluble components , and increase
interactions between the drug and excipients , all of which can adversely
affect the physical and chemical stability of the drug substance to
the detriment... | elucidating the crystal structures ,
transformations , and thermodynamics
of the two zwitterionic hydrates ( hy2 and hya ) of 3-(4-dibenzo[b , f][1,4]oxepin-11-yl - piperazin-1-yl)-2,2-dimethylpropanoic
acid ( db7 ) rationalizes the complex interplay of temperature , water
activity , and ph on the solid form st... |
nonpenetrating glaucoma surgeries ( npgs ) , namely , deep sclerectomy and viscocanalostomy with or without implantation of surgical adjuvants , have been developed as an alternative to conventional filtering procedures [ 16 ] .
these procedures aim to reduce the intraocular pressure ( iop ) by enhancing the natural ... | purpose . to report one - year results of phacoemulsification combined with deep sclerectomy and goniosynechiolysis ab interno for chronic glaucoma associated with peripheral anterior synechiae ( pas )
. methods .
we retrospectively analyzed medical charts of 16 patients ( 20 eyes ) treated by one - site combined p... |
several groups of animals enter into symbiotic relationships with algae , the zoochlorellae of hydra being a well - known example ( habetha et al . 2003 ; kawaida et al .
sacoglossan slugs are unique , however , in that they perform photosynthesis and fix carbon in a light - dependent manner using plastids that they ... | plastids sequestered by sacoglossan sea slugs have long been a puzzle .
some sacoglossans feed on siphonaceous algae and can retain the plastids in the cytosol of their digestive gland cells . there , the stolen plastids ( kleptoplasts ) can remain photosynthetically active in some cases for months .
kleptoplast lo... |
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