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the constructs of time and space saturate our discourses , as the two experiential domains are , of course , fundamental to how we interact with and organize our environment . considerable empirical evidence has revealed interactions between time and space in both brain and behavior , from low - level perception to h...
a large literature has documented interactions between space and time suggesting that the two experiential domains may share a common format in a generalized magnitude system ( atom theory ) . to further explore this hypothesis , here we measured the extent to which time and space are sensitive to the same sensorimotor...
spleen and lymph nodes ( lns ) are respectively involved in the filtration of blood and lymph flow , and immune responses are induced by the activation of lymphocytes and natural killer ( nk ) cells , which is dependent on antigen presenting cells ( apcs ) including dendritic cells and macrophages . lymph nodes are b...
the lymph node ( ln ) is an important immune system in which a number of antigenpresenting cells are present that induce rapid immune responses to foreign antigens . while a great number of macrophages exist in lymph nodes , recent studies using animal models have shown that lymph node sinus macrophages are associate...
chronic inflammatory diseases of the airways such as asthma and copd are no exceptions [ 1 , 2 ] . for better detection of blood vessels , specific stains are needed as haematoxylin and eosin alone are not specific enough . the most commonly used tissue vessel markers in studies of the respiratory tract have been ant...
background and objective . using collagen iv staining , we have previously reported that the reticular basement membrane ( rbm ) is hypervascular and the lamina propria ( lp ) is hypovascular in copd airways . this study compared collagen iv staining with vessels marked with anti - factor viii and examined vessel p...
silk fibroin ( sf ) is a natural polymer produced by a variety of insects and spiders . the best characterized silks are the dragline silk from the spider nephila clavipes and the cocoon silk from the domesticated silkworm bombyx mori , which has been used in textile production clinical sutures , and more recently as...
the objective of this proof - of - concept study was to develop a platform for controlled drug delivery based on silk fibroin ( sf ) and to explore the feasibility of using sf in oral drug delivery . the sf - containing matrixes were prepared via spray - drying and film casting , and the release profile of the model ...
as a unique family of g protein - coupled receptors , newfound protease - activated receptors ( pars ) are widely expressed on the cells in central nervous system ( cns ) , including neurons and glial cells , regulating cell responses to extracellular serine proteases as cell surface sensors and contributing extensivel...
protease - activated receptor 2 ( par-2 ) , which is abundantly expressed in astrocytes , is known to play major roles in brain inflammation . however , the influence of the natural agonist of par-2 , tryptase , on proinflammatory mediator releasedfrom astrocytes remains uninvestigated . in the present study , we fou...
fiber optic endoscopic evaluation of swallowing ( fees ) revealed severe oropharyngeal dysphagia with poor oral bolus control , premature spillage leading to predeglutitive aspiration , a severely delayed swallowing reflex , and residues in the epiglottic valleculae and in the piriform sinus , with solid and half - sol...
objective : to report on dysphagia as initial sign in a case of anti - iglon5 syndrome and provide an overview of the current literature.methods:the diagnostic workup included cerebral mri , fiber optic endoscopic evaluation of swallowing ( fees ) with the fees tensilon test , a videofluoroscopic swallowing study , evo...
gitelman syndrome ( gs ) is a rare autosomal - recessive inherited disorder with 99% penetrance caused by inactivating mutations in the slc12a3 gene , localized on the 16q13 chromosome . this genetic defect impairs the function of the thiazide - sensitive sodium - chloride cotransporter in the distal convoluted renal...
gitelman syndrome ( gs ) is an autosomal - recessive condition characterized by hypokalemia , hypomagnesemia and hypocalciuria . very little information is available in the literature to guide the management of pregnant patients with gs . we report a case of a 27-year - old woman with gs who became pregnant and des...
kimura 's disease ( kd ) is a rare benign disorder of unknown etiology , and is observed primarily in young asian men . kd may the result of an allergic or chronic inflammatory response , preferentially occurring in the head and neck . the clinical symptoms are usually manifest either as painless unilateral lymphad...
we report the first observed case of kimura 's disease occurring during hemodialysis , involving the thoracic and abdominal lymph nodes , which spontaneously resolved nearly completely after two months . early diagnosis and recognition of kimura 's disease may spare both the patient and doctor from the need for unnec...
over the past two decades , there have been numerous calls worldwide to reform and innovate healthcare delivery to meet objectives , such as the provision of collaborative , safe , patient centered care . heath information technology ( hit ) will play a key role in facilitating healthcare delivery to meet these objec...
objectivesthis paper reviews organizational and social issues ( osis ) in health information technology ( hit).methodsa review and synthesis of the literature on osis in hit was conducted.resultsfive overarching themes with respect to osis in hit were identified and discussed : scope and frameworks for defining osis in...
chronic myocardial inflammation can be identified as a specific pathogenic mechanism in a significant proportion of dilated cardiomyopathy ( dcm ) patients , either with viral persistence ( e.g. , coxsackievirus , adenovirus , parvovirus b19/b19v ) or in terms of a post - viral anti - cardiac immunity maintained even a...
backgroundviral infection and anti - cardiac immunity are involved in the pathogenesis of dilated cardiomyopathy ( dcm ) . immunity targeting particular antigens may evoke expansion of reactive t - cell clones.material/methodsmyocardial tissues from explanted hearts were investigated for clonal t - cell - receptor- (...
activator protein-1 ( ap1 ) is a transcription factor that consists of either homo- or heterodimers of the jun and fos family proteins . it regulates gene expression in response to a variety of stimuli , including environmental stresses , uv radiation , cytokines , and growth factors . ap1 in turn controls a number...
activator protein-1 ( ap1 ) is a transcription factor that consists of the jun and fos family proteins . it regulates gene expression in response to a variety of stimuli and controls cellular processes including proliferation , transformation , inflammation , and innate immune responses . ap1 binds specifically to ...
experimental details , xray crystal structure of culoaded f33y cubmb , malditof mass spectra , epr simulation , and extra uv / vis , epr spectra are provided in the supporting information . as a service to our authors and readers , this journal provides supporting information supplied by the authors . such materi...
abstractrational protein design has been proven to be a powerful tool for creating functional artificial proteins . although many artificial metalloproteins with a single active site have been successfully created , those with dual active sites in a single protein scaffold are still relatively rare . in this study , ...
the world health organization ( who ) defines it as a locally invasive polymorphic neoplasia that often has a follicular or plexiform pattern in a fibrous stroma . clinicians emphasize that ameloblastoma is a benign tumor but is locally aggressive . in 20% of cases , it is localized in the maxilla where it can be p...
ameloblastoma is the most common tumor of odontogenic origin . there are various types of this tumor and confusion still exists among the clinicians about the correct classification . multicystic ameloblastoma is the most frequent subtype while unicystic ameloblastoma can be considered as a variant of the solid or ...
vegetable oils are an important component of human diet because they provide nutritional properties , flavor , and consistency . recently intensive research on the pressure changes of physical properties of vegetable oils has been done in several laboratories . during food manufacture , for example , olive and seed...
this paper presents measurements of sound velocity and attenuation in olive oil , with known chemical composition , as a function of pressure , within the range of pressure up to 0.7 gpa . dependencies of sound velocity , relative ultrasonic wave attenuation , volume , and adiabatic compressibility on pressure show ...
all known compounds were characterized by h and c nmr and melting point determination ( for solids ) and compared with literature values . all new compounds were characterized by h , c , f nmr spectra , high - resolution mass spectrometry ( hrms ) , and melting point determination ( for solids ) . h , c , and...
a mild , practical protocol has been developed for the suzuki cross - coupling of unprotected thienylsulfonamides from air- and bench - stable organotrifluoroborates in the absence of a protecting group on the sulfonamide nitrogen . the developed synthetic method can be applied to the preparation of various a...
we investigated a tbe outbreak , comprising 6 cases , in a mountain region in western austria in july 2008 . the index case occurred in a 43-year - old shepherd who had stayed for 24 days at his alpine pasture ( 1,564 m above sea level ) before he was hospitalized for nonbacterial urethritis and nonspecific influenza...
we report transmission of tick - borne encephalitis virus ( tbev ) in july 2008 through nonpasteurized goat milk to 6 humans and 4 domestic pigs in an alpine pasture 1,500 m above sea level . this outbreak indicates the emergence of ticks and tbev at increasing altitudes in central europe and the efficiency of oral t...
the oral rehabilitation of patients with implants requires the placement of stable prostheses enabling security , comfort and longevity to treatment . the beginning of the construction of prosthetic treatment requires the faithful reproduction of the working cast of the situation found in mouth , to reduce the ...
objectivethe aim of this study was to test a new portable vibrator for plaster pouring ( developed for this purpose ) , comparing the effect of its use on the accuracy of working cast of implant - supported restorations to the conventional vibrator . material and methodsfrom a master cast with 2 implants , 30 tra...
non - straight steps that change the direction of movement account for 3550% of all steps when walking indoors1 . patients with stroke fall not only during walking but also during standing turn or transfer between bed and wheelchair2 , 3 . therefore , the ability to take multidirectional steps is important ...
[ purpose ] the purpose of this study was to determine the effect of stepping limb and step direction on step distance and the association of step distance and stepping laterality in step difference with walking ability and motor dysfunction . [ subjects and methods ] the subjects were thirty - nine patients wi...
the major current use of genomic technology by the military is collecting dna from present and former members of the military in order to facilitate the identification of remains . the collection , called a biobank or biorepository , is the armed services repository of specimen samples for the identification of remai...
advances in genomic science are attracting the interest of the u.s . military for their potential to improve medical care for members of the military and to aid in military recruitment , training , specialization , and mission accomplishment . while researchers have explored the ethical , legal , and social issues ...
as recent improvements in ultrasound techniques have increased diagnostic accuracy , ultrasonography is being used as an initial screening procedure in acute and chronic biliary tract disease , especially in gallbladder disease . since present real - time ultrasonography shows high - quality imaging , the absence of ...
to define the significance of nonvisualization of the gallbladder by ultrasonography , we studied follow - up data on 31 cases in which the gallbladder could not be identified despite adequate fasting . thirty one cases of gallbladder disease included 15 cases of chronic cholecystitis due to cholelithiasis ( 13 cases...
the benzo [ c ] furan system , trivially called isobenzofuran , has come to light from 1960s . there are records for the reactivity of substituted isobenzofurans as dienes in the diels - alder reaction [ 1 , 2 ] . citalopram ( figure 1 ) , a well - known compound , affects serotonin metabolism in the brain and thus...
the paper describes a convenient method for the preparation of 4-substituted phenyl-5-[1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-yl]-2h-1,2,4-triazole-3-thiones . the structures of the synthesized compounds are established by the results of lcms , 1h nmr , 13c nmr , and ir and elemental analyses . the mercaptot...
entamoeba histolytica is an enteric anaerobic protozoan parasite with about 50 million infections and over 100,000 deaths worldwide annually ( 14 ) . developing countries have the highest prevalence of amoebiasis because of human faeces have not been properly separated from food and water supplies . however , socio...
background : this study was conducted with the aim of determining surface water contamination with cysts of entamoeba histolytica using pcr in rasht city , northern iran.methods : in this cross - sectional study , 49 water samples including 18 rivers and 6 wetlands were collected from different regions near the city of...
the emergence of non - invasive forms of prenatal genetic testing has the potential to expand the availability of highly sensitive and specific prenatal testing . in particular , new tests that target and analyze cell - free fetal dna ( cffdna ) in the maternal bloodstream as early as nine weeks into pregnancy ( 1 ) ...
objective(s)to determine how adults in the united states ( us ) view non - invasive prenatal testing using cell - free fetal dna ( cffdna testing ) in order to help estimate uptake.study designa national sample of 1,861 us - based adults was surveyed using a validated online survey instrument . the survey was adminis...
neurofibroma is a benign peripheral nerve sheath tumor arising from the schwann cells and perineural fibroblasts . oral involvement is noted in 3.4 - 92% of adults and 40% of children with nf1 . a 28-year - old male patient reported [ figure 1 ] with the chief complaint of a painless swelling in the right upper bac...
neurofibroma is a benign peripheral nerve sheath tumor and is the most frequent tumor of neural origin . its presence is one of the clinical criteria for the diagnosis of neurofibromatosis type 1 ( nf1 ; a common hereditary disease occurring in one out of every 3000 births ) . the diagnosis can sometimes be made at...
elevated intraocular pressure ( iop ) is a frequent complication of intraocular inflammation , affecting 5 to 19% of uveitis patients . elevated iop can be acute or chronic and both presentations can lead to optic nerve damage and visual field defect in glaucoma secondary to hypertensive uveitis . iop elevation may...
purpose . to review the clinical outcome of patients with hypertensive uveitis . methods . retrospective review of uveitis patients with elevated intraocular pressure ( iop ) > 25 mmhg and > 1-year follow - up . data are uveitis type , etiology , viral ( vu ) and nonviral uveitis ( nvu ) , iop , and medical and/or...
chorea may be the manifestation of a wide variety of degenerative , vascular , metabolic , or toxic disorders involving the central nervous system , in which dysfunction of the basal ganglia , particularly of the striatum , is generally assumed to be responsible . we report an index case of generalized chorea seconda...
chorea is a rare manifestation of poisoning . we report an index case of a young woman who developed generalized chorea following propiconazole toxin ingestion . as large series on neurological complications of toxic compounds are difficult to be compiled , it is of interest to report our experience . this report a...
the metabolic syndrome ( mets ) was first described by kylin , a swedish physician , in 1923 as a clinical association between hypertension and gout . he described it as syndrome x which is a constellation of insulin resistance , hyperglycemia , hypertension , low high - density lipoprotein cholesterol ( hdl - c ) ...
metabolic syndrome ( mets ) or syndrome x which is a constellation of insulin resistance , hyperglycemia , hypertension , low high - density lipoprotein cholesterol ( hdl - c ) , and increased very - low - density lipoprotein ( vldl ) and triglyceride ( tg ) levels . it is one of the main threats for public health ...
surgical management of displaced subcapital fractures of the femoral neck continues to be challenging . internal fixation , hemiarthroplasty , and total hip replacement could be considered as appropriate solutions . for internal fixation , most orthopaedic surgeons choose either a dynamic hip screw ( dhs ) or multipl...
objectives . to study the correlation between avascular necrosis and the demographics , time elapsed from fracture to surgery , quality of reduction , garden classification , and the position of the screw following use of the dynamic hip screw ( dhs ) in the treatment of subcapital neck fractures . methods . a prospe...
neuroendocrine tumors of the lung include atypical and typical carcinoids , large cell neuroendocrine carcinomas and small cell lung carcinomas . typical carcinoids ( tcs ) and atypical carcinoids ( acs ) of the lung have rapidly increased in the last 30 years with an incidence of 1.57/100.000 in 2003 . tcs are oft...
abstractwell - differentiated neuroendocrine tumors ( nets ) of the lung occur as typical and atypical carcinoids . little is known about the biology of these tumors in respect of their ability to metastasize or the probability of development of concomitant neuroendocrine tumors . here we report a patient diagnosed...
to understand how cells read off information from the genome at the right time at the right position , we have to learn the sequence motifs that the regulatory factors recognize and bind to . a large variety of experimental methods yield sequences that are enriched in binding sites of regulatory factors . methods t...
the discovery of regulatory motifs enriched in sets of dna or rna sequences is fundamental to the analysis of a great variety of functional genomics experiments . these motifs usually represent binding sites of proteins or non - coding rnas , which are best described by position weight matrices ( pwms ) . we have r...
the combination of structural genomics efforts and computational modeling has resulted in a large amount of 3d structure information for proteins . however , to a large degree , this structural information has not been translated into functional information . for example , understanding substrate specificity , catalysi...
sitehound - web ( http://sitehound.sanchezlab.org ) is a binding - site identification server powered by the sitehound program . given a protein structure in pdb format sitehound - web will identify regions of the protein characterized by favorable interactions with a probe molecule . these regions correspond to pu...
psychological science can make important contributions to prevention and treatment of chronic illness ( taylor , 2006 ) . to address the challenge , a new field of health psychology has evolved over the last 30 years . the divisions of health psychology of the british psychological society and the european health psy...
human behaviour plays a significant role in most of the leading causes of death . psychological science has the potential to enhance health outcomes through a better understanding of health promoting and health damaging behaviours . health psychology and the related field of behavioural medicine focus on the interp...
toluene diisocyanate ( tdi ) is an imperative chemical substance used in the production of polyurethane foams , elastomers , paints and coatings and cause a variety of health problems in workers who are exposed in work places ( 1 ) . health effects that induced by tdi consist of asthma , chronic obstructive lung dise...
backgroundtoluene diisocyanate ( tdi ) is an imperative chemical substance used in the production of polyurethane foams , elastomers , paints and coatings that cause a variety of health problems in workers who are exposed in work places . this study aimed to determine the asthma symptoms and serum specific ige levels...
the most common underlying mechanism of bioactive peptides has been studied in angiotensin - converting enzyme ( ace ) inhibition [ 24 ] . although the ace inhibitor effects of bioactive peptides are most often studied , the vasorelaxant activity has also shown an important evidence for lowering blood pressure . it...
sericin - derived oligopeptides obtained from silk cocoons were investigated for the in vivo hypotensive effect and investigated for the underlying mechanism involved in vasodilation in isolated rat thoracic aorta . in normotensive anesthetized rats , oligopeptides induced an immediate and transient hypotensive activit...
monomethylmercury is a neurotoxin that poses significant risks to human health1 due to its bioaccumulation in food webs . sunlight degradation to inorganic mercury is an important component of the mercury cycle that maintains methylmercury at low concentrations in natural waters . rates of photodecomposition , howe...
traumatic brain injuries ( tbis ) have multiple causes , from motor vehicle accidents , falls , sports - related injuries , violence , and military activity , making tbi a serious health concern around the world . the world health organization has stated that the incidence and long - term consequences of tbis will co...
traumatic brain injury ( tbi ) is a widespread epidemic with severe cognitive , affective , and behavioral consequences . tbis typically result in a relatively rapid inflammatory and neuroinflammatory response . a major component of the neuroinflammatory response is astrocytes , a type of glial cell in the brain . ...
pleomorphic adenomas are benign salivary gland tumors , which predominantly affect the superficial lobe of the parotid gland . nature of the tumor can be explained on the basis of its epithelial and connective tissue origin . . surgical excision of the tumor mass forms the mainstay of treatment , with utmost care t...
backgroundpleomorphic adenomas are benign salivary gland tumors , which predominantly affect the superficial lobe of the parotid gland . the pleomorphic nature of the tumor can be explained on the basis of its epithelial and connective tissue origin . the tumor has a female predilection between 3050 years of age...
a technique of orthotopic rat liver transplantation has been shown in a recent journal of visualized experiments paper . portal vein and infra - hepatic vena cava anastomoses were performed using the quick - linker assisted cuff technique . this technique was chosen among other revisions of the original kamada 's t...
orthotopic rat liver transplantation is a popular model , which has been shown in a recent jove paper with the use of the " quick - linker " device . this technique allows for easier venous cuff - anatomoses after a reasonable learning curve . the device is composed of two handles , which are carved out from scalpe...
the inflammasomes are a group of cytosolic protein complexes that function as a molecular platform for caspase-1-dependent proteolytic maturation and secretion of interleukin ( il)-1 and il-18 ( 1 - 4 ) . of the members of the nucleotide binding oligomerization domain ( nod)-like receptor ( nlr ) inflammasomes , the ...
the inflammasome is a multi - protein complex that induces maturation of inflammatory cytokines interleukin ( il)-1 and il-18 through activation of caspase-1 . several nucleotide binding oligomerization domain - like receptor family members , including nlrp3 , recognize unique microbial and danger components and play...
traumatic eye injuries ( tei ) involved about 3% of cases visited in emergency departments ( ed ) of developing countries ( 1 ) . it is estimated that trauma causes blindness and visual impairment in many referees of ophthalmic emergency ( 2 ) . most of these injuries are hard to diagnose in initial ed assessment ....
introduction : traumatic eye injuries ( tei ) involved about 3% of cases referred to the emergency departments of developing countries . lens dislocation is one of the critical cases of ophthalmic emergencies . the present study was aimed to evaluate the diagnostic accuracy of ultrasonography in detection of trauma...
traditionally , health has been regarded as the absence of disease . however , over the decades , it has been recognized that the social , psychosocial , economic , and cultural factors influence health . this holistic concept implies that all sectors of the society influence health and emphasizes on promotion and ...
introduction : the sense of coherence ( soc ) has been suggested to be highly applicable concept in the public health area because a strong soc is stated to decrease the likelihood of perceiving the social environment as stressful . this reduces the susceptibility to the health - damaging effect of chronic stress by ...
protein conformational diversity is a key feature to understand protein function . since the early studies of max perutz on the t and r forms of hemoglobin , increasing experimental evidence supports the notion that native state of proteins is not unique . in fact , the native state is better represented by an ensemb...
pcdb ( http://www.pcdb.unq.edu.ar ) is a database of protein conformational diversity . for each protein , the database contains the redundant compilation of all the corresponding crystallographic structures obtained under different conditions . these structures could be considered as different instances of protein...
prior studies have demonstrated the efficacy and effectiveness of both typical ( 1st generation ) and atypical ( 2nd generation ) antipsychotic agents in reducing schizophrenic symptoms ( purdon et al 2000 ; hirsch et al 2002 ; kane et al 2002 ) . however , the likelihood of sustaining control of schizophrenic symptoms...
prior studies have demonstrated the importance of treatment persistence with anti - psychotic agents in sustaining control of schizophrenic symptoms . however , the conventional approach in measuring treatment persistence tended to use only the first prescription episode even though some patients received multiple pres...
epidermoid cysts are benign sequestration cysts in body that may be either congenital or acquired . the congenital variety is related to aberrant embryogenic ectodermal implantation during at the time of closure of neural groove or when epithelial surfaces fuse . acquired cysts are due to traumatic iatrogenic impla...
intraoral epidermoid cyst of buccal mucosa is generally an uncommon entity . epidermal inclusion cyst refers sequestration of epidermal elements into the dermal and deeper tissue during the fetal period in line of fusion of embryonic process or acquired due to implantation of the epithelium due to trauma or surgery ....
sarcoidosis is a common systemic disorder of unknown etiology which is characterized by the formation of noncaseating epithelioid cell granulomas . in addition to their occurrence in systemic sarcoidosis , these granulomas have also been observed in various parenchymas and in the lymph nodes associated with other gra...
lymph node swelling in the setting of malignancy generally suggests metastasis of the primary tumor . a granulomatous reaction , i.e. sarcoid reaction , occurring within the lymph nodes draining carcinomas is a well - known but uncommon occurrence . the phenomenon is especially rarely seen in colon carcinoma . we h...
microbial ecology provides the link between basic biochemical and molecular studies on toxicity reduction by microbial metabolism and environmental studies that determine exposure . this link provides the ability to determine which microorganisms are responsible for the actual transformations in nature , thereby esta...
periodic limb movement disorder ( plmd ) is diagnosed when there are periodic limb movements during sleep ( plms ) exceeding norms for age , clinical sleep disturbance , and the absence of another primary sleep disorder or reason for the plms . pathological periodic limb movement index ( plmi ) is defined as > 15 m...
periodic limb movement disorder ( plmd ) is characterized by pathological periodic limb movements during sleep , insomnia and/or diurnal sleepiness , and the absence of another primary sleep disorder . we report a patient with complex partial seizures who developed plmd while taking topiramate ( tpm ) . he had no e...
samples : edta - anticoagulated blood samples were collected from 51 sika deer ( cervus nippon yesoensis ) that were maintained in captivity for the purpose of meat processing in the kushiro district ( hokkaido , japan ) in june and july 2011 . dna was extracted from 200 l of whole blood using the qiaamp dna bloo...
abstracthemotropic mycoplasmas ( hemoplasmas ) are cell - wall deficient , epierythrocytic bacteria that cause infectious anemia in several mammalian species . the prevalence of hemoplasma species was examined by screening and species - specific pcr using blood samples collected from 51 sika deer in hokkaido , ...
to explore the advantages of using artificial neural networks ( anns ) to recognize patterns in colposcopy to classify images in colposcopy . transversal , descriptive , and analytical study of a quantitative approach with an emphasis on diagnosis . the training test e validation set was composed of images collecte...
objectiveto explore the advantages of using artificial neural networks ( anns ) to recognize patterns in colposcopy to classify images in colposcopy.purposetransversal , descriptive , and analytical study of a quantitative approach with an emphasis on diagnosis . the training test e validation set was composed of ima...
a convenience sample of 160 public swimming pools from 2 metropolitan atlanta , georgia , counties was used to collect filter backwash samples for parasite examination during a 7-week period ( late august october 2006 ) . information on age of swimmers , pool type , pool size , and number of swimmers was gathered . ...
cryptosporidium spp . and giardia intestinalis have been found in swimming pool filter backwash during outbreaks . to determine baseline prevalence , we sampled pools not associated with outbreaks and found that of 160 sampled pools , 13 ( 8.1% ) were positive for 1 or both parasites ; 10 ( 6.2% ) for giardia sp . ...
infectious diseases caused by bacterial , viral , fungal , or parasitic pathogens continue to be the leading cause of morbidity and mortality worldwide despite the availability of effective antimicrobial agents and vaccines over the last fifty years or more . the continual emergence of previously undescribed ...
extending along the dynamic continuum from conflict to cooperation , microbial infections always involve symbiosis ( sym ) and pathogenesis ( pat ) . there exists a dynamic sym - pat duality ( dspd ) in microbial infection that is the most fundamental problem in infectomics . dspd is encoded by the genomes of both ...
we performed three interrelated nested studies in an occupational cohort of 151,347 employees in finland ( 16 ) . the eligible population of 151,347 participants was linked to national health and prescription registers through unique personal identification codes assigned to all citizens in finland . for all partic...
objectiveto examine antidepressant medication use as a risk factor for type 2 diabetes and weight gain.research design and methodsa series of nested studies within a prospective cohort of 151,347 working - aged men and women including 9,197 participants with continuing antidepressant medication , 224 with severe depres...
implantation of a prosthetic aortic valve too small for the patient s body size could lead to an increased hemodynamic burden by creating left ventricular outflow obstruction , resulting in a higher mean transprosthetic pressure gradient ( tpg ) . this condition after aortic valve replacement ( avr ) is known as pro...
background in this study , we sought to determine the effect of the mean transprosthetic pressure gradient ( tpg ) , measured at 6 weeks after aortic valve replacement ( avr ) or avr with coronary artery bypass grafting ( cabg ) on late all - cause mortality.methodsbetween january 1998 and march 2012 , 2,276 patients...
gnathostomiasis is a food - borne parasitic zoonosis caused by the third stage larvae of the genus gnathostoma . human infection is mainly resulted from eating raw or undercooked intermediate hosts ( e.g. fish , eels , and loaches ) or paratenic hosts ( e.g. crustaceans , freshwater fish , and mammals ) containing th...
the present study reports a human case of cutaneous gnathostomiasis with recurrent migratory nodule and persistent eosinophilia in china . a 52-year - old woman from henan province , central china , presented with recurrent migratory reddish swelling and subcutaneous nodule in the left upper arm and on the back for 3 m...
a 60-year - old man has been in your intensive care unit with septic shock for 5 days and he has required a norepinephrine infusion for the entire time . frank v ritacca , carmine simone and randy wax despite advances in providing care for patients with septic shock , mortality rates remain unacceptably high . exog...
decision - making in the intensive care unit is often very difficult . although we are encouraged to make evidence - based decisions , this may be difficult for a number of reasons . to begin with , evidence may not exist to answer the clinical question . second , when there is evidence it may not be applicable t...
the effect of the usb syllabus on resident education was assessed in a prospective observational cohort pilot study . the institutional review board approved the study and informed consent was obtained from study participants . the residency program in internal medicine at the jhbmc is an accreditation council for ...
backgroundthe acquisition of new knowledge is a primary goal of residency training . retrieving and retaining influential primary and secondary medical literature can be challenging for house officers . we set out to investigate the effect of a universal serial bus ( usb ) drive loaded with landmark scientific articl...
there has been a dramatic improvement in the survival outcome of acute lymphoblastic leukemia ( all ) patients with a better understanding of molecular biology , the use of combination chemotherapy protocols , risk stratification using clinical , genetic , and molecular parameters , improvements in supportive care , al...
background : a dramatic improvement in the survival of acute lymphoblastic leukemia ( all ) patients in the last three decades has been observed . mcp 841 protocol is an old but effective tool with tolerable toxicities . the objective of this study was to estimate the relapse - free survival of all patients treated...
the best - known physiological role of active vitamin d or 1,25 ( oh)2 vitamin d concerns the maintenance of calcium and phosphate homeostasis by promoting their intestinal absorption , thus ensuring their availability for the skeletal mineralisation process . to achieve this well - established endocrine effect , 1,25 ...
background . vitamin d is important for bone health , although high loading doses have been associated with an increase in fracture risk . the mechanisms remain uncertain . aim . we hypothesize that supraphysiological concentrations of 1,25 ( oh)2 vitamin d may inhibit formation by increasing the production of wn...
autism / autistic spectrum disorders ( asd ) are lifelong neurodevelopmental disorders diagnosed within the first 3 years of life . kanner1 described autism in 11 children manifesting symptoms of withdrawal from human contact as early as age 1 year and postulated the origins of asd in prenatal stages . the diagnost...
autism spectrum disorder ( asd ) is a pervasive neuro - developmental disorder characterized by impaired social interaction , reduced / absent verbal and non - verbal communication , and repetitive behavior during early childhood . the etiology of this developmental disorder is poorly understood , and no biomarkers h...
an advantage of rna - seq over other gene expression profiling technologies is that it allows a comprehensive assay that does not require probes for targets to be specified in advance . it has particularly been used for de novo detection of splice junctions and allows genome wide expression profiling of organisms wit...
rna - seq is increasingly being used for gene expression profiling . in this approach , next - generation sequencing ( ngs ) platforms are used for sequencing . due to highly parallel nature , millions of reads are generated in a short time and at low cost . therefore analysis of the data is a major challenge and...
renal amyloidosis is characterized by the extracellular deposition of amyloid , a proteinaceous fibrilar material , presenting positive staining of congo red , in the kidney1 ) . primary amyloidosis is extremely rare in children and the causes of secondary amyloidosis in children include familiar mediterranean fever ...
a 13-year - old girl was diagnosed with non - cystic fibrosis ( cf)-related multifocal bronchiectasis accompanied by nephrotic - range proteinuria of unknown cause . on renal biopsy , there were many segmental homogeneous deposits of amyloid tissue with positive congo red staining in the glomeruli and interstitium . ...
during april 928 , 2007 , five persons became ill and died within a few days at village belechuapara , nadia district , west bengal , india , which borders bangladesh . the index case - patient ( case - patient 1 ) was a 35-year - old male farmer addicted to country liquor derived from palm juice . hundreds of bats...
an intrafamilial outbreak in west bengal , india , involving 5 deaths and person - to - person transmission was attributed to nipah virus . full - genome sequence of nipah virus ( 18,252 nt ) amplified from lung tissue showed 99.2% nt and 99.8% aa identity with the bangladesh-2004 isolate , suggesting a common source...
pulmonary alveolar proteinosis ( pap ) was first described by rosen et al . in 1958 the clinical course of the disease is variable , ranging from spontaneous resolution to death due to pneumonia or respiratory failure . pulmonary alveolar proteinosis occurs in three clinically distinct forms : congenital , secondar...
idiopathic pulmonary alveolar proteinosis ( pap ) is a rare disorder in which lipoproteinaceous material accumulates within alveoli . there were few reports on asian populations with idiopathic pap . we retrospectively reviewed 38 patients with idiopathic pap in korea . we assessed clinical features , therapeutic...
most stroke survivors experience changes in the level of consciousness , loss of motor and sensory functions , language disorder , and loss of cognitive and perceptual abilities . in addition , performance of activities of daily living becomes limited and participation in social activities decreases1 , 2 . ...
[ purpose ] the purpose of this study was to assess the effect of horseback riding simulation machine training on trunk balance and gait of patients with chronic stroke . [ subjects and methods ] the subjects were 20 patients hospitalized for treatment after being diagnosed with stroke . horseback riding simu...
traumatic brain injury ( tbi ) is a significant contributor to mortality and morbidity in children and adults throughout the world [ 1 , 2 ] . there are over one million new cases of tbi each year in the united states alone and together these account for over 7.6 billion dollars in medical costs and other expenditure...
traumatic brain injury ( tbi ) is the greatest contributing cause of death and disability among children and young adults in the united states . the current paper briefly summarizes contemporary literature on factors that can improve outcomes ( i.e. , promote resilience ) for children and adults following tbi . for t...
as technological advancements have been made in endoscopy , the occurrence of duodenal tumors has increased . but when we examine patients by endoscopy , tumors of the duodenum are not often diagnosed . most duodenal tumors of the first portion are benign , but the incidence of malignancy increases as they are more...
we report herein the case of a lobulated and pedunculated hyperplastic polyp in the third portion of the duodenum causing anemia and occult blood in stools , which was detected by capsule endoscopy ( ce ) and treated with snare polypectomy . a 71-year - old man was referred to our hospital because of anemia and occul...
the effect of cardiac resynchronisation therapy ( crt ) in patients with heart failure without left bundle branch block ( lbbb ) is disputable . we present a case of a patient with rate - dependent lbbb . a 55-year - old woman with dilated cardiomyopathy , a left ventricular ( lv ) ejection fraction of 32% ( bloodpoo...
a 55-year - old woman with dilated cardiomyopathy and rate - dependent left bundle branch block had a cardiac resynchronisation therapy ( crt ) device implanted . during implantation , the maximum rate of left ventricular pressure rise ( dp / dtmax ) was measured invasively . this case presents a description of the...
a 17-year - old girl presented with complaints of a progressively increasing swelling over the front of her left chest over the previous 5 months . the swelling was not painful , situated just adjacent to her left breast , with no associated shortness of breath . she did not complain of an engorgement of the left b...
chondrosarcoma of the chest wall is a rare primary neoplasm found to occur in elderly men . patients present with an enlarging , painful , anterior chest wall mass arising from either the vicinity of the costochondral junction or the sternum . treatment includes wide resection with appropriate chest wall reconstruc...
between february 1997 and may 2000 , seven patients in whom tubular foreign bodies were present underwent removal procedures involving the coaxial snare technique ( table 1 ) . the foreign bodies were either stents which were malpositioned or had migrated from their correct position in the vascular system ( n=2 ) , a...
objectiveto evaluate the utility and advantages of the coaxial snare technique in the retrieval of tubular foreign bodies.materials and methodsusing the coaxial snare technique , we attempted to retrieve tubular foreign bodies present in seven patients . the bodies were either stents which were malpositioned or had m...
a 46-year - old gentleman presented with sudden onset of loss of vision following blunt trauma to the right eye . the patient had sustained the injury when he was assaulted with a stone . he had undergone cataract surgery with posterior chamber ( pc ) iol in the right eye three months ago elsewhere . on examination ...
a 45-year - old man presented with post - traumatic aniridia . we describe the combined surgery done to treat both aniridia and epiretinal membrane simultaneously . a combined aniridia intraocular lens and vitreoretinal surgery was done . the case report highlights the advantage of combined surgery in terms of cost...
hallux valgus ( hv ) is a common deformity characterized by angulation of the hallux starting at the first metatarsophalangeal ( mtp ) joint towards the second toe . following the angulation of the first metatarsal bone towards the medial side , lateral deviation and internal rotation through the longitudinal a...
[ purpose ] to investigate the relationship between hallux valgus ( hv ) deformity and the position of rearfoot joints , and its effects on the quality of life , pain , and related functional status of women with bilateral hallux valgus ( hv ) . [ subjects and methods ] the subjects were 27 right - dominant wom...
atrial septal defect ( asd ) is a form of congenital heart defect that enables blood flow between two compartments of the heart called the left and right atria . normally , the right and left atria are separated by a septum called the interatrial septum . if this septum is defective or absent , then oxygen - rich blo...
background : atrial septal defect ( asd ) is a congenital heart defect that leads to shunting of blood between left and right atria . it may be asymptomatic and sometimes may present with heart failure . surgical repair is definitive , but currently non - surgical procedure is used to close the defect.materials and...
although uncommon , leydig cell testicular neoplasms are the most common sex cord - stromal tumors and comprise 13% of all testicular neoplasms . the majority have been recognized in males between the ages of 20 and 60 years . the malignant variants occur only in adults and metastasis is the major criterion of malign...
leydig cell tumors are rare testicular tumors of the male gonadal interstitium . although uncommon , leydig cell testicular neoplasms are the most common sex cord - stromal tumors and comprise 13% of all testicular neoplasms . this tumor is always benign in children and approximately 90% are benign in adults . in m...
the perioperative behavioural studies demonstrate that children are at greater risk of experiencing turbulent anaesthetic induction and adverse behavioural sequelae . furthermore , children admitted to hospitals are displaced from their comfort zone of home and family . proper pre - operative planning is necessary ...
background and aims : the perioperative behavioural studies demonstrate that children are at greater risk of experiencing turbulent anaesthetic induction and adverse behavioural sequelae . we aimed to compare the efficacy of midazolam 0.5 mg / kg with triclofos sodium 100 mg / kg as oral premedication in children und...
a point mutation in the beta - globulin gene alters the hemoglobin structure and results in chronic hemolytic anemia and increased blood viscosity . this leads to an heterogeneous phenotypic spectrum : increased morbidity and mortality is due to a higher susceptibility to infections , intermittent vaso - occlusive ev...
background and objectiveslack of suitable donors and regimen related toxicity are major barriers for hematopoietic stem cell transplantation ( hsct ) in patients with sickle cell disease ( scd ) . the aim of the study is the assessment of efficacy and toxicity of treosulfan - based conditioning regimen for scd also w...
the patient was prepared in the prone position over the radiolucent chest frame in a flexed position . the head and the upper back should be placed slightly lower than the lower back and buttocks for sufficient circulation of the head when the systolic blood pressure should be maintained at 90100 mmhg to reduce bleed...
the major problems of revision surgery for recurrent lumbar disc herniation ( ldh ) include limited visualization due to adhesion of scar tissue , restricted handling of neural structures in insufficient visual field , and consequent higher risk of a dura tear and nerve root injury . therefore , clear differentiation...
a prospective clinical trial was conducted on a consecutive series of the patients with primary io overaction or secondary overaction due to superior oblique palsy . institutional review board approval was obtained and signed informed consent was obtained from all participants in accordance with the declaration of he...
purpose : to evaluate the alteration of lower lid configuration and function with anterior transposition surgery of the inferior oblique ( io ) muscle.patients and methods : a prospective clinical trial was conducted on a consecutive series of patients underwent anterior transposition of the io as a sole operation . ...
this investigation was approved by the institutional review board of the catholic university of korea , seoul , korea , and followed the tenets of the declaration of helsinki . patients with glaucoma that met the inclusion criteria were consecutively included from patients examined for glaucoma at the glaucoma clinic...
purposewe evaluated whether the structure function relationship in glaucoma patients with parafoveal scotoma or peripheral scotoma differs with the use of frequency doubling technology ( fdt ) or short - wavelength automated perimetry ( swap ) compared to standard automated perimetry ( sap).methodsglaucoma patients wi...
this is a retrospective case series where we obtained the data by reviewing the records of patients operated for optical p.k . 181 patients operated for optical p.k . at our institute between october 2005 and october 2007 and those who completed at least one - year follow - up were included for analysis . in patients...
aim : to study the indications , risk factors , postoperative course , and long - term survival of corneal transplants done for optical purposes.design:retrospective case series.materials and methods : data were obtained by reviewing the records of 181 patients operated at our institute ( h.v . desai eye hospital ) b...
endoscopic retrograde cholangiopancreatography ( ercp ) and endoscopic ultrasound ( eus ) are increasingly utilized in the field of gastroenterology to diagnose and treat various upper gastrointestinal diseases . more than 500,000 ercps are performed annually in the united states for pancreaticobiliary disorders and ...
background and study aims : it is unknown whether significant incidental upper gastrointestinal lesions are missed when using non - forward - viewing endoscopes without completing a forward - viewing exam in linear endoscopic ultrasound ( eus ) or endoscopic retrograde cholangiopancreatography ( ercp ) exams . we eva...
eed is a localized , low - grade form of leukocytoclastic vasculitis of unknown pathogenesis characterized by persistent , symmetrical , red - purple papules , nodules , and plaques affecting the extensor surfaces of the extremities , the ears , trunk and buttocks . dermatitis herpetiformis is an autoimmune blisterin...
erythema elevatum diutinum ( eed ) is a rare skin disease that initially presents as leucocytoclastic vasculitis and later resolves with fibrosis . dermatitis herpetiformis is an autoimmune blistering disease characterized by granular deposits of immunoglobulin a ( iga ) in dermal papillae . we report a rare associ...
non - hodgkin lymphoma ( nhl ) consists of a heterogeneous group of malignancies with varied clinical presentation and biological behaviors . the estimated number of new cases in 2014 is 70 000 , which represents 4% of all cancers diagnosed and 3% of cancer deaths in the united states . the histological subtypes of...
proton therapy ( pt ) is a highly conformal type of radiation therapy that can target the tumor while sparing dose to surrounding normal tissues . this study reviews a single institution 's experience managing patients with non - hodgkin lymphoma ( nhl ) treated with pt . eleven patients with nhl were treated with ...
it is where life begins , and it never ends . in this story , there once were two sisters who were happy and healthy and enjoying life together ( figure 1 ) . but then , all of a sudden , my sister was losing weight unexpectedly , and her weight was close to 90 lb . i remember my mother looking up her symptoms in h...
editor s note : this article is adapted from the address ms . delahanty delivered as the recipient of the american diabetes association s ( ada ) outstanding educator in diabetes award for 2015 . she delivered the address in june 2015 at the association s 75th scientific sessions in boston , mass . a webcast of t...
currently , 1/9 people older than 65 years of age have alzheimer s disease ( ad ) , and 1/3 of people older than 85 are diagnosed with ad . as the aging population expands , the projected number of ad cases is expected to triple by 2050 , with economic costs escalating from $ 214 billion in 2014 to $ 1.2 trillion in 20...
the inflammatory response is a fundamental driving force in the pathogenesis of alzheimer s disease ( ad ) . in the setting of accumulating immunogenic a peptide assemblies , microglia , the innate immune cells of the brain , generate a non - resolving immune response and fail to adequately clear accumulating a pepti...
we conducted a retrospective cohort study of all adult , nondiabetic patients undergoing a first kidney transplant at the mayo clinic arizona between june 1999 and january 2008 . after institutional review board approval , we identified the study cohort by systematic chart review . absence of diabetes before transp...
objectivenew - onset diabetes after kidney transplantation ( nodat ) has adverse clinical and economic implications . a risk score for nodat could help identify research subjects for intervention studies.research design and methodswe conducted a single - center retrospective cohort study using pretransplant clinical ...
achalasia cardia is a rare primary esophageal motor disorder , which is diagnosed on the basis of esophageal manometry.1 typical manometry findings in achalasia are aperistalsis of esophageal body and incomplete relaxation of lower esophageal sphincter ( les).2 based on average esophageal body amplitude , achalasia is ...
pneumatic dilation ( pd ) is an effective treatment for achalasia cardia . outcome of pd , however , varies among different studies . recently , some groups started considering laparoscopic myotomy to be competitive to pd in treatment of achalasia considering dreaded complication like perforation following the latt...
cardiovascular disease is a major cause of morbidity and mortality and accounts for up to 70% of the major adverse clinical advents in the first year following liver transplantation . indeed , cardiovascular disease remains the leading cause of non graft - related death in the longer term . although the high incid...
background : the prevalence of coronary artery disease ( cad ) in end - stage liver disease ( esld ) being evaluated for orthotopic liver transplantation ( olt ) is unclear based on variable definition used for cad.objective:the aim of this study to investigate the prevalence of abnormal stress myocardial perfusion sin...
motoneuron loss is the common feature of several neurodegenerative diseases , as well as mechanical injuries affecting the spinal cord ( sc ) . among neurodegenerative diseases , amyotrophic lateral sclerosis ( als ) and spinal muscular atrophy ( sma ) represent the most common diseases affecting spinal and brainstem...
retrogradely transported toxins are widely used to set up protocols for selective lesioning of the nervous system . these methods could be collectively named molecular neurosurgery because they are able to destroy specific types of neurons by using targeted neurotoxins . lectins such as ricin , volkensin , or mod...
recently , in addition to the high prevalence of infectious diseases , the incidence of noncommunicable disease is alarmingly increasing in the developing countries . although there are some more recent studies indicating the decline of cvd in africa , ncds are generally showing rapid rise in these countries . one of...
background . the social and economic changes taking place in developing countries are influencing the pace at which hypertension and its risk factors are expanding . as opposed to the already established inverse association in developed nations , the association between socioeconomic status and hypertension in deve...
transvaginal ultrasound - guided oocyte pick - up ( opu ) for assisted reproductive technology ( art ) treatment was first reported in 1985 ( 1 ) . since then , this technique has been rapidly widespread throughout the world , as a replacement for laparoscopic oocyte retrieval . currently , the ovarian stimulation ...
background : the purpose of this study was to evaluate the effect of needle type on pain and bleeding during oocyte pick - up ( opu).methods : from may through november 2013 , patients undergoing opu from a single follicle without any analgesic treatment were including this study . eligible patients ( n=75 ) were ran...
patients over 30 years of age with type 2 diabetes , diabetic retinopathy , and a visual acuity of 20 / 50 or better were enrolled in this prospective observational study . all participants were seen at seoul national university hospital from october 2011 to march 2012 . the baseline pobf analyses were performed in...
purposeto investigate the effect of cilostazol on ocular hemodynamics and to determine whether the administration of cilostazol increases the ocular blood flow in patients with diabetic retinopathy.methodsthis prospective observational study investigated the effect of orally administered cilostazol on diabetic retinopa...
in recent decades , intensive research in the field of oxidative damage indicates that exercise exacerbates the generation of reactive oxygen ( ros ) and reactive nitrogen species ( rns ) , some of which are free - radicals [ 15 ] . a free - radical ros / rns refer to oxygen or nitrogen containing free - radicals...
antioxidant defences are essential for cellular redox regulation . since free - radical production may be enhanced by physical activity , herein , we evaluated the effect of acute exercise on total antioxidant status ( tas ) and the plasma activities of catalase , glutathione reductase , glutathione peroxidase , and su...
psoriasis is a lifelong , chronic , and immune - mediated systemic disease with preferential skin involvement , which affects approximately 13% of the caucasian population [ 1 , 2 ] . psoriasis may appear at any age ; however , over 75% of patients belong to a clear subgroup , that develops the disease before the age...
psoriasis is a lifelong , chronic , and immune - mediated systemic disease , which affects approximately 13% of the caucasian population . the different presentations of psoriasis require different approaches to treatment and appropriate prescriptions according to disease severity . the use of topical therapy remai...
we describe the lymphoscintigraphy findings of a 25-year - old female patient who was undergoing presurgical workup for lymphangiomas of the vulva . she had a history of treatment for disseminated tuberculosis 6 years back and presented with herpetiform oozing vesicles in the external genitalia . single - photon emis...
urologists have traditionally received their surgical training through the halstedian apprenticeship model of see one , do one , teach one. despite the original success of this model , it relied heavily upon the accumulation of considerable operating experience gathered during several years of demanding training . ove...
introductionsimulation is becoming an increasingly popular educational tool in numerous surgical specialities , including urology . this article reviews the current role of urological simulators ; discussing their need , availability , incorporation and current limitations.material and methodsa literature review of t...
we investigated four single nucleotide polymorphisms in the gene - encoding angiotensin converting enzyme 2 ( ace2 ) , a gene on the x - chromosome whose raas product modulates cardiac structure and function , for association with hypertrophic traits in 227 individuals belonging to 22 hcm families with known founder di...
hypertrophic cardiomyopathy , a common , inherited cardiac muscle disease , is primarily caused by mutations in sarcomeric protein - encoding genes and is characterized by overgrowth of ventricular muscle that is highly variable in extent and location . this variability has been partially attributed to locus and alle...
tension pneumothorax occurs due to a one way communication between lung parenchyma and the pleural cavity leading to air entrapment in the pleural cavity with each inspiration with inability to release it during expiration . it requires prompt diagnosis and immediate treatment or it may lead to respiratory failure an...
tension pneumothorax is a life threatening condition that occurs when the intrapleural pressure exceeds atmospheric pressure . it requires prompt diagnosis and immediate treatment . tension pneumothorax developing postoperatively after cardiac surgery is not uncommon but occurrence in the operating room during card...
ankle sprain is a common injury for athletes who perform cutting maneuvers , landings , or frequent jumps or make contact with other players1 . approximately 4075% of individuals develop residual symptoms or chronic ankle dysfunction due to lateral ankle sprain2 . in addition , functional ankle instability may ...
[ purpose ] limited research has been performed in spite of biomechanical evaluation of jump landing with kinesio taping . therefore , the main objective of this study was to evaluate the effect of kinesio taping applied to athletes . in this study , the authors wished to investigate the effect of kinesio tap...
an increase in overweight and obesity is an important problem to be addressed in public health . in particular , patients with schizophrenia are well known to be prone to be overweight ( 13 ) . obesity and being overweight increase the risks of dyslipidemia , hypertension , cardiovascular disease , insulin - resistan...
background : patients with schizophrenia reportedly have a high prevalence of obesity . one of the reasons is a poor choice of diet . the goal of this study was to clarify characteristics of the dietary intake across the strata of the body mass index ( bmi ) and to compare the general population and patients with s...
hepatoid adenocarcinomas are tumors that arise outside the liver but which resemble hepatic tissue and produce alpha - fetoprotein ( afp ) . hepatoid adenocarcinomas have been identified in many sites , including the stomach , lung , rectum , renal pelvis , ovary , uterus , and vagina . until now , only one case of...
we report two cases of uterine carcinosarcoma associated with alpha - fetoprotein ( afp)-producing hepatoid adenocarcinoma . samples were obtained from two women aged 63 and 82 years . serum afp levels of the two samples were 10,131 and 401 ng / ml , respectively . histologically , in both cases the tumor cells w...