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the initial manifestations are neurologic in 40% of patients , hepatic in 40% and psychiatric in 15% of patients .
wd is an autosomal recessive condition characterized by inability of the liver to transport and store normally absorbed dietary copper , resulting in abnormal deposition of copper in the basal ganglia , ... | wilson 's disease ( wd ) is a relatively rare disease of copper metabolism .
the diagnosis is often missed initially .
the presentation is usually neurologic or hepatic , seen in 40% of patients .
psychiatric presentation of wd is reported in only 15% of patients .
we present a 32-year - old patient with severe... |
asthma is a chronic respiratory condition that affects over 7 million united states ( us ) children .
acute episodes are characterized by airway constriction and excess production of mucus and may require medication to restore normal breathing .
several different triggers have been found to set off episodes , inclu... | risk factors , such as parental smoking , are commonly associated with increased asthma symptoms and hospitalizations of children .
deseret mutual benefits administrators ( dmba ) is the health insurer for employees of the church of jesus christ of latter - day saints and their families . due to religious proscriptio... |
inflammation is associated with atherosclerosis as well as with fatty liver disease ( fld ) .
both diseases are common in the western world and several studies indicate that there could be a link between both disorders .
inflammation causes formation of vascular atheromas and thinning of the plaque 's fibrous cap... | background and aims . local and systemic inflammation represent a major feature of atherosclerotic cardiovascular disease ( cvd ) and are also linked to nonalcoholic fatty liver disease ( nafld ) .
studies indicate that nafld might be a risk factor for cvd whereas low - to - moderate alcohol consumption is associated... |
the prevalence of surgical trauma as a public health
hazard in low - resource settings globally has been
severely neglected .
traditionally , surgery has been
viewed as a resource - intense intervention that does not
fit in with most effective public health models .
however , surgery can provide solutions t... | the prevalence of surgical trauma as a global public health hazard has been severely
neglected .
trauma surgeons in uganda and canada have developed the kampala trauma score ( kts ) ,
a trauma severity index specific to east african contexts .
hospitals in tanzania have begun to use this
tool to measure their... |
when the combined oral contraceptive pill ( coc ) was introduced over six decades ago,1,2 it was designed to be taken in a regimen that mimicked the normal menstrual cycle .
this requires active pills to be taken for 21 days followed by 7 days without hormones , resulting in a withdrawal bleed .
it has been common ... | backgroundthe purpose of this study was to determine attitudes to , and provision of , extended regimens for taking the combined oral contraceptive pill ( coc ) by specialist contraception practitioners from three contrasting specialist contraception services in london.methodsan online cross - sectional survey was admi... |
the implantable collamer lens ( icl ) is a flexible , posterior chamber phakic intraocular lens .
it is implanted in the ciliary sulcus and is vaulted to avoid contact with the crystalline lens .
icl implantation is an effective option for the treatment of refractive errors , offering an optical quality superior to... | purpose . to evaluate the anterior segment , the anatomical position of the implantable collamer lenses ( icl ) , and its relationship to adjacent ocular structures using ultrasound biomicroscopy ( ubm )
. methods . in a prospective study ,
142 myopic eyes of 93 patients implanted with visian icl were subjected to ... |
image denoising is a common preprocessing step in many magnetic resonance ( mr ) image processing and analysis tasks , such as segmentation , registration or parametric image synthesis .
many filtering methods use the signal averaging principle which is based on the natural spatial pattern redundancy in the images... | magnetic resonance images are normally corrupted by random noise from the measurement process complicating the automatic feature extraction and analysis of clinical data .
it is because of this reason that denoising methods have been traditionally applied to improve mr image quality .
many of these methods use the ... |
antidepressants are widely used in the treatment of depression , which is the most common psychiatric disorder with an enormous burden globally . for a long time , tricyclic antidepressants ( tcas ) were the mainstay of drug treatment of depression .
thromboembolic phenomena are also very common and need treatment wi... | depressive illness and thromboembolic disorders are both highly prevalent .
warfarin is frequently combined with an antidepressant drug , the choice of which depends mainly on the risk of a hemorrhagic complication .
patients requiring the warfarin are often in the older age group , where the newer antidepressants ... |
basaloid squamous cell carcinoma ( bscc ) as defined by the world health organization is an aggressive , high - grade , variant of squamous cell carcinoma ( scc ) composed of both basaloid and squamous components .
the tumor arises most frequently in the head and neck region , the most common sites being epiglottis ,... | basaloid squamous cell carcinoma ( bscc ) is an aggressive , high - grade , variant of squamous cell carcinoma ( scc ) , which is uncommon in the oral cavity but slightly more common in the oropharynx .
we present two cases of bscc , one arising in the floor of the mouth and the other arising on the lateral border of... |
pain is one of the most commonly experienced symptoms in dentistry and is a major concern to the dentist .
pain , in many instances , is considered as a caution signal . in practice of dentistry , pain is no more a warning signal , instead it is an evil to be conquered .
one of the most important aspects of the pra... | background : the ideal maxillary injection should produce a rapid onset of profound pulpal anesthesia for multiple teeth from a single needle penetration .
the main objective is to compare the efficacy of articaine 4% and lidocaine 2% and to compare anterior middle superior alveolar nerve block ( amsanb ) and infraor... |
surgery is the main treatment strategy for gastric cancer ; only r0 resection anticipates a potential cure .
the prognosis of initially unresectable gastric cancer is poor ; approximately 50% of patients have recurrent disease after a curative resection .
this suggests that micrometastases are already present , in ... | s-1 , a novel oral fluoropyrimidine , is an effective therapeutic agent for gastric cancer .
herein , we report a case with locally advanced gastric cancer that achieved a curative resection after s-1 monotherapy as neoadjuvant treatment .
a 68-year - old man was diagnosed with gastric cancer and massive lymphadeno... |
changes in hepatic contour that mimic cirrhosis radiographically , but lack the classic pathological attributes of cirrhosis , are referred to as pseudocirrhosis .
features of portal hypertension , such as portosystemic venous collaterals and ascites , as well as hepatic surface nodularity can be seen on computed tom... | pseudocirrhosis refers to a condition that shows changes in hepatic contour that mimic cirrhosis radiographically in the absence of the typical histopathological findings of cirrhosis .
this condition has been observed in patients with cancer metastatic to the liver , both in those who have undergone prior systemic c... |
bhopal gas leak disaster is the biggest industrial disaster in human history . on the night of 2/3 december 1984 , about 40 tons of methyl isocyanate ( mic ) from tank 610 of union carbide india limited ( ucil ) factory at bhopal , in central india , leaked into the surrounding environment .
this leak of an extremel... | bhopal disaster is an important milestone in indian industrial psychiatry .
the disaster was not only the biggest industrial disaster but also one in which complex forces have joined hands to demy the mental health needs of the population . though the biggest general population epidemiological study over 5 years was ... |
fever , defined as a rectal temperature higher than 38c , is the most common complaint
among children admitted to emergency departments ( 1 ) .
infectious and noninfectious triggers cause a release of pyrogenic cytokine
such as interleukin-1 , interleukin-6 , tumor necrosis factor - alpha ( tnf- ) and
interfero... | backgroundfever is the most common complaint in pediatric medicine and its treatment is
recommended in some situations .
paracetamol is the most common antipyretic drug , which
has serious side effects such as toxicity along with its positive effects .
diclofenac is
one of the strongest non - steroidal anti -... |
the incidence of vesicoenteric fistulas has been reported to occur in 0.01% to 0.05% of surgical admissions1 ) . in one study of 56 instances of vesicoenteric fistulas ,
hepatocellular carcinomas ( hccs ) account for 90% of primary liver cancers ; up to 80% of hccs occur in korea occur in patients with cirrhotic live... | ileovesical fistula is a very rare clinical entity , the most frequent cause of which is crohn 's disease .
furthermore , it is an exceptionally rare complication of malignancies .
we experienced one case of ileovesical fistula which had been caused by hepatocellular carcinoma ( hcc ) arising from the noncirrhotic ... |
primary central nervous system ( cns ) lymphoma is a relatively uncommon malignancy , accounting for approximately 6% of all malignant cns neoplasms . they typically occur in middle - aged and older adults , although it can be seen more commonly in younger patients with human immunodeficiency virus ( hiv ) or transplan... | a 65-year - old male presented to our institution with acute - onset headache .
imaging studies demonstrated a mass in the region of the pineal gland , with subsequent histopathology findings being consistent with large b cell lymphoma .
the patient was treated with methotrexate , but ultimately did not survive . p... |
familial hypomagnesaemia with hypercalciuria and nephrocalcinosis ( fhhnc , omim # 248250 ) is a rare autosomal - recessive renal tubular disorder caused by mutations in the cldn16 or cldn19 gene , which , respectively , encode the tight junction - associated proteins , claudin-16 and -19 [ 13 ] .
these transmembrane... | familial hypomagnesaemia with hypercalciuria and nephrocalcinosis is an autosomal - recessive disease caused by mutations in the cldn16 or cldn19 genes , which encode tight junction - associated proteins , claudin-16 and -19 .
the resultant tubulopathy leads to urinary loss of mg2 + and ca2 + , with subsequent nephro... |
ischemic stroke and cancer represent a frequent coincidence with large - scale significance on stroke etiology , diagnostics and treatment options .
evidence from early autopsy and recent clinical studies suggest a prevalence of ischemic stroke in cancer patients of approximately 3% . considering the annual incidence... | backgrounddue to the lack of specific diagnostic markers , the diagnosis of cancer - related stroke strongly depends on its phenotype .
distinct dwi lesion patterns with involvement of multiple vascular territories have been reported repeatedly in cancer - related stroke but have not been addressed in detail in a sel... |
the reported incidence of ureteral injury during colorectal surgery has ranged from 0.2 to 4.5 % .
the use of prophylactic lighted ureteral stent ( lus ) placement has gained more importance with the advent of laparoscopic colectomy .
lighted stents help in the visual identification of the ureters during a laparosc... | objective : the placement of indwelling ureteral catheters during colorectal surgery has been recommended for prevention of ureteral injuries . with the advent of laparoscopic colectomy ( lco ) ,
the role of preoperative placement of lighted ureteral stents ( lus ) has also become commonplace .
we sought to evaluat... |
cine mri , combined with ( c)spamm ( ( c)spamm = ( complementary ) spatial modulation of magnetization ) encoding technology [ 14 ] , admits disambiguation of local tissue motion , thus enabling the extraction of myocardial deformation and strain , which are known to correlate with cardiac pathologies . in particular ,... | myocardial deformation and strain can be investigated using suitably encoded
cine mri that admits disambiguation of material motion .
practical limitations
currently restrict the analysis to in - plane motion in cross - sections of the heart
( 2d + time ) , but the proposed method readily generalizes to 3d + ti... |
skull base defects can derive from both traumatic and nontraumatic causes . in the traumatic group ,
nonsurgical trauma is the most common overall , and surgical ( iatrogenic ) damage is a minor cause . in the nontraumatic group
, skull base erosion can be caused by high intracranial pressure due to tumor obstructi... | introduction a substantial body of literature has been devoted to the distinct characteristics and surgical options to repair the skull base . however , the skull base is an anatomically challenging location that requires a three - dimensional reconstruction approach .
furthermore , advances in endoscopic skull base... |
a 38-year - old male was admitted to the local hospital with pneumonia . despite medical treatment
, his symptoms did not show any signs of improvement , and he was therefore referred to our hospital .
when he arrived at the emergency department , initial arterial blood gas analysis ( abga ) showed a ph of 7.451 , ... | a 38-year - old male was admitted with symptoms of upper respiratory infection . despite medical treatment ,
his symptoms of dyspnea and anxiety became aggravated , and bilateral lung infiltration was noted on radiological imaging studies .
his hypoxemia failed to improve even after the application of endotracheal ... |
milk as an excretion of the mammary gland can carry numerous xenobiotic substances , which constitute a technological risk factor for dairy products and , above all , for the health of the consumer .
determination of the residual concentrations of metals in milk could be an important direct indicator of the hygieni... | concentrations of toxic heavy metals ( cadmium ( cd ) , lead ( pb ) ) and major nutritional and trace elements ( ca , mg , p , cu , fe , mn , se , zn ) were analyzed in the milk of simmental ( n = 20 ) and holstein - friesian ( n = 20 ) cows from an organic farm .
elements were determined using inductively couple... |
multiple sclerosis , a chronic and debilitating inflammatory disease of the cns is characterized by myelin damage . in multiple sclerosis , although resident oligodendrocyte progenitors are found around the lesions , they remain in a quiescent state and remyelination is incomplete . thus , therapeutic strategies that p... | background : progesterone as a sex steroid hormone is thought to affect and prevent demyelination , but its role in promoting myelin repair is far less investigated . in this study , remyelinating potential of progesterone in corpus callosum was evaluated on an experimental model of ms.methods:in this experimental stud... |
biosurfactants are amphiphilic molecules which have the ability to depict a wide variety of surface activity .
they comprise both a hydrophobic and a hydrophilic group that aid in its accumulation between fluid phases .
because of this property , they allow easy accessibility to nonpolar hydrocarbons so that microo... | biosurfactants are surface - active compounds derived from varied microbial sources including bacteria and fungi .
they are secreted extracellularly and have a wide range of exciting properties for bioremediation purposes .
they also have vast applications in the food and medicine industry . with an objective of is... |
the first patient was a 31-year - old caucasian woman admitted to our facility after sustaining 65% tbsa thermal injuries in a residential fire .
the patient received lactated ringers during initial resuscitation titrated to a combined endpoint of urine output and tissue perfusion according to clinical judgment suppo... | fluid resuscitation is the foundation of management in burn patients and is the topic of considerable research .
one adjunct in burn resuscitation is continuous , high - dose vitamin c ( ascorbic acid ) infusion , which may reduce fluid requirements and thus decrease the risk for over resuscitation .
research in pr... |
a 39-year - old woman 161 cm tall weighing 51 kg was diagnosed with uterine myoma and an abdominal wall mass and scheduled for laparoscopic myomectomy .
she was premedicated with 2 mg of midazolam and a 0.5 mg atropine intramuscular injection 30 minutes before arrival to the operation room .
she was monitored intra... | bladder perforation during laparoscopy is a recognized , uncommon complication .
we present two cases of bladder perforation during laparoscopic gynecologic operations that were detected by gaseous distention of the urinary bag .
bladder perforation occurred through laparoscopic division of adhesion .
one bladder... |
it is responsible for the death of 1 in 10 adults , with 4.9 million deaths occurring worldwide each year .
prisoners are also more likely to have comorbid conditions ( psychiatric disorders ) and substance dependence , and there is less likelihood of smoking cessation among prisoners in the absence of intensive inte... | background : tobacco smoking is an integral part of prison life and an established part of the culture .
little attention has been paid to prevention of smoking in prison .
approximately 7080% of prisoners have been identified as current smokers .
aim : to assess the effectiveness of smoking cessation interventio... |
complete ureteral triplication , the presence of three individual ureters originating from the kidney and draining into three separate orifices , is a rare congenital anomaly .
patients with such anatomy may be predisposed to recurrent infections , renal colic , and incontinence secondary to associated obstruction an... | a patient with a complete right ureteral triplication presented with recurrent pyelonephritis and flank pain that was refractory to medical management .
evaluation showed that the atrophic upper - most renal moiety had been chronically obstructed and was associated with a dilated ureter .
intraureteral and intraven... |
from december 2005 to september 2006 , drug - naive type 2 diabetic patients , aged 1879 years , with a1c 7% and 10% , were recruited at 98 clinical centers in the u.s .
inclusion criteria included fasting c - peptide > 1.0 ng / ml , bmi 40 kg / m , and renal status as follows : glomerular filtration rate > 60 ml / m... | objectivedapagliflozin , a novel inhibitor of renal sodium - glucose cotransporter 2 , allows an insulin - independent approach to improve type 2 diabetes hyperglycemia . in this multiple - dose study
we evaluated the safety and efficacy of dapagliflozin in type 2 diabetic patients.research design and methodstype 2 d... |
the ankle joints play an important role in gait . the structure of foot is adapted for
locomotion and the alignment of the foot and ankle plays an important role in standing and
gait1 , and supporting weight during
gait2 .
the proper functioning of the
ankle joint is necessary for daily life , recreation and ... | [ purpose ] this study was performed to examine how the balance of lower limbs and the
muscle activities of the tibialis anterior ( ta ) , the medial gastrocnemius ( gcm ) , and the
peroneus longus ( pl ) are influenced by isotonic and isokinetic exercise of the ankle
joint .
[ subjects ] the subjects of this s... |
a new trial conducted by the canadian critical care trials group investigated the impact of different diagnostic approaches on outcomes of patients suspected of having ventilator - associated pneumonia ( vap ) .
immediate administration of adequate antibiotic therapy is critical to improving survival in patients with... | the results of a recently published canadian study suggest that bronchoalveolar lavage and endotracheal aspiration are associated with similar clinical outcomes and similar overall use of antibiotics in critically ill patients with suspected ventilator - associated pneumonia ( vap ) .
the study , however , does not p... |
nephropathy is widely encountered among the people of entire world irrespective of the age , racial , environmental , and geographical variability .
the etiology behind this complication is broad ranging from substance - induced to various metabolic and physiological disturbances , paneling nephropathy amongst the 10... | the nephroprotective activity of the ethanolic extract of bauhinia variegata ( linn . ) whole stem against cisplatin - induced nephropathy was investigated by an in vivo method in rats .
acute nephrotoxicity was induced by i.p .
injection of cisplatin ( 7 mg / kg of body weight ( b.w . ) ) .
administration of eth... |
the pemphigus diseases , which include some of the most severe bullous autoimmune skin reactions , are seen predominantly in middle - aged and elderly individuals .
all nonendemic pemphigus diseases , including paraneoplastic pemphigus , have been reported to occur in adolescents and even very rarely in children youn... | pemphigus herpetiformis ( ph ) is one of the less common forms of pemphigus .
ph in children is unreported .
we describe a case of a child who developed ph .
observation .
a 12-year - old boy was seen at our department with erosive plaques , vesicles , and crusted cutaneous lesions associated with severe itchin... |
in the cancer research field , vitamin d has emerged as the most prolific topic in the last decade with work connecting it with risk reduction in various epithelial cancers . aside from calcium homeostasis , vitamin d exerts a wide range of immunogenic and antiproliferative activities in the body .
of particular inte... | aim : the aim was to determine serum vitamin d levels in breast cancer patients and to assess its risk association with grade and stage of the tumor.materials and methods : ninety breast cancer patients and equal number of age - matched healthy females were recruited into the study by consecutive sampling over a period... |
over the last 2 decades , advances in surgical technology combined with a growing consumer demand have created a shift towards gynecologic minimally invasive surgery ( mis ) .
the safety and efficacy of mis have been thoroughly documented in the literature and include decreased blood loss , a shorter hospital stay , ... | objective .
to assess the impact of gynecology residents ' previous laparoscopic experience on the learning curve of robotic suturing techniques and the value of initial structured teaching in dry lab prior to surgery .
methods .
thirteen gynecology residents with no previous robotic surgery experience were divid... |
oral and oropharyngeal cancers , including cancers of the lip , alveolar bone , gingiva , buccal mucosa , floor of the mouth , oropharynx , salivary glands , maxillary sinus , and mobile tongue , are the sixth most common type of cancer in the world.1,2 oral cancer accounts for 3% of all cancers in the united states wi... | purposesquamous cell carcinoma ( scc ) of the tongue has a relatively high incidence of all oral cancers .
some studies have reported a relationship between intraoral dental prosthesis and scc of the tongue ; however , this relationship remains controversial .
the purpose of this study was to investigate the relati... |
the dynamic kinetic resolution of
-halo -keto esters
via an asymmetric cross - benzoin reaction is described .
a chiral n - heterocyclic carbene catalyzes the umpolung addition of aldehydes to racemic -keto esters .
the resulting
fully substituted -halo glycolic ester products are obtained
with high levels ... | |
, the hemoglobin mainly distributes in the red blood cell ( kundu et al 2003 ; weber and fago 2004 ) .
structurally , each molecule of hemoglobin contains four globin chains and heme ( kundu et al 2003 ; weber and fago 2004 ) .
the four globin chains ( two alpha chains and two beta chains ) are depicted as a tetram... | hemoglobin is an important protein found in the red cells of many animals . in humans ,
the hemoglobin is mainly distributed in the red blood cell .
single amino acid substitution is the main pathogenesis of most hemoglobin disorders . here
, the author used a new gene ontology technology to predict the molecular... |
erythrovirus ( formally parvovirus ) b19 ( b19 ) causes a wide range of diseases in humans .
b19 is a currently the only accepted member of the erythrovirus genus and the only erythrovirus known to be pathogenic in humans .
several workers reported cases of children with fulminant or acute hepatitis with acute b19 ... | background : fulminant hepatitis and biliary atresia are serious problems and their causes have not been explained well .
we investigated whether or not erythrovirus b19 is a candidate etiologic agent in such liver disease patients who had undergone liver transplantation.methods : liver tissues from 47 patients consi... |
the collaborative cross ( cc ) is a mouse genetic reference population conceived 10 years ago as a community resource for systems genetics ( threadgill and churchill 2012 ; threadgill et al .
it is a panel of recombinant inbred ( ri ) lines generated by randomly mixing the genetic diversity of eight extant inbred mo... | the collaborative cross ( cc ) is a panel of recombinant inbred lines derived from eight genetically diverse laboratory inbred strains .
recently , the genetic architecture of the cc population was reported based on the genotype of a single male per line , and other publications reported incompletely inbred cc mice t... |
methane is a powerful greenhouse gas , and its atmospheric concentration has been steadily increasing over the past 300 years .
there are two major ways in which methane is removed from the environment : aerobic oxidation by a specialized group of bacteria and anaerobic oxidation by a specialized group of archaea .
... | recent sequencing of the genome and proteomic analysis of a model aerobic methanotrophic bacterium , methylococcus capsulatus ( bath ) has revealed a highly versatile metabolic potential . in parallel ,
environmental genomics has provided glimpses into anaerobic methane oxidation by certain archaea , further supporti... |
all surviving members of the 2012 outbreak in jordan , their exposed contacts , and their household members who were identified serologically as either mers - cov positive or indeterminate were asked to consent to further participation .
participants were asked to provide a follow - up serologic specimen so we could ... | to determine how long antibodies against middle east respiratory syndrome coronavirus persist , we measured long - term antibody responses among persons serologically positive or indeterminate after a 2012 outbreak in jordan .
antibodies , including neutralizing antibodies , were detectable in 6 ( 86% ) of 7 persons ... |
the importance of trace elements and their role in biological cycling and homeostasis has become evident in recent years [ 1 , 2 ] , due to deficiency of essential trace elements or excess of potentially toxic elements accumulation in human body for a long time , which are responsible for various diseases .
so the fo... | a rapid , accurate , and high performance method of high resolution sector field inductively coupled plasma mass spectrometry ( hr - icp - ms ) combined with a small - size sample ( 0.1 ml ) preparation was established .
the method was validated and applied for the determination of 16 selected plasma trace elements ... |
leishmaniasis is a vector - borne parasitic disease caused by intramacrophage protozoa of the genus leishmania , transmitted generally by at least 30 species of sand flies ( either phlebotomus or lutzomyia genera ) and rarely by congenital and parenteral routes [ 1 , 2 ] . depending on the species of leishmania involve... | in sudan human leishmaniasis occurs in different clinical forms , that is , visceral ( vl ) , cutaneous ( cl ) , mucocutaneous ( ml ) , and post - kala - azar dermal leishmaniasis ( pkdl ) . clinical samples from 69 sudanese patients with different clinical manifestations were subjected to a pcr targeting the cytochrom... |
it is a benign melanocytic lesion typically < 2 mm in thickness , with an annual malignant transformation rate of one in 8,845.1 polypoidal choroidal vasculopathy ( pcv ) is a recurrent and relapsing chorioretinopathy characterized by grape - like subretinal vascular lesions associated with retinal pigment epithelium d... | we report a case of a caucasian female who developed active polypoidal choroidal vasculopathy ( pcv ) at the edge of a stable choroidal nevus and was successfully treated with verteporfin photodynamic therapy .
no active polyp was detectable on indocyanine green angiography 2 years after treatment , and good vision w... |
a persistent sciatic artery ( psa ) is a rare vascular anomaly with an estimated incidence of 0.020.04% and with a high rate of complications such as aneurysm formation , thromboembolism , and ischemia , that may lead to amputation .
we present a case of a female patient with complete symptomatic ambilateral psa and ... | summarybackgrounda persistent sciatic artery ( psa ) is a rare vascular anomaly with an estimated incidence of 0.020.04% and with a high rate of complications such as aneurysm formation , thromboembolism , and ischemia , that may lead to amputation.case reportwe present a case of a female patient with complete symptoma... |
archaea and bacteria were also believed to synthesize lysine through diaminopimelate until it was reported that the extremely thermophilic bacterium thermus thermophilus synthesizes lysine through -aminoadipate [ 58 ] . during lysine biosynthesis in the budding yeast saccharomyces
cerevisiae , -aminoadipate is synthe... | most ascomycetous yeasts have 2 homocitrate synthases ( hcss ) . among the fungal lysine
biosynthesis - related genes , only the hcs gene was duplicated in the course of evolution .
it was recently reported that hcs of saccharomyces cerevisiae has an additional function in nuclear activities involving chromatin reg... |
tuberculosis is an infectious disease that continues to be major public health problem in ethiopia due to the expansion of hiv epidemic .
increased disease burden caused by tb and hiv coinfection makes it critically essential to accurately detect tb infection among persons with hiv .
world health organization ( who... | the new who 2011 guidelines on tb screening among hiv - infected individuals recommend screening using four tb symptoms ( current cough , fever , weight loss , and night sweats ) .
this study aimed to assess the performance of who 2011 tb symptom screening algorithm for diagnosing pulmonary tb in hiv patients and ide... |
reproductive tract infections ( rti ) including sexually transmitted infections ( sti ) present a huge disease burden and adversely impact the reproductive health .
their consequences are far more devastating and widespread among women as compared to men [ 1 , 2 ] .
vaginitis is one of the commonest rti and is char... | vaginitis is one of the commonest reproductive tract infections in sexually active women . in the present study clinicoetiological characterization of infectious vaginitis amongst 380 women of reproductive age group ( 1845 years )
was done .
bacterial vaginosis ( bv ) was detected by nugent 's scoring , candida inf... |
prostate cancer is one of the most prevalent cancers in male and the second most common cause of death due to cancer among males in the united states of america .
men with a family history of prostate cancer are at increased risk of this disease . about 86% of men who have prostate cancer
recent studies indicate th... | background : androgen deprivation is the basis of treatment for advanced stages of prostate cancer . cardiovascular disease may be a risk factor for mortality in prostate cancer . therefore , we decided to evaluate the effect of androgen deprivation therapy ( adt ) on the cardiovascular risk factors in patients with pr... |
the primary objective of melanoma treatment is to specifically eradicate the tumor while minimizing damage to normal tissue . in order to accomplish this goal
one group of proteins that exhibit selective expression in cancer includes a group of proteins whose expression is otherwise normally limited to germ cells .
... | germ cell protein expression in melanoma has been shown to correlate with malignancy , severity of disease and to serve as an immunologic target for therapy . however , very little is known about the role that germ cell proteins play in cancer development .
unique germ cell pathways include those involved in immortal... |
allergic rhinitis ( ar ) is an allergic inflammation of the nasal airways and is characterized by sneezing , nasal congestion , nasal itching , and rhinorrhea , in any combination .
ar affects approximately 60 million people in the united states and the prevalence is about 1030% in adults and nearly 40% in children [... | allergic rhinitis ( ar ) is an allergic inflammation of the nasal airways .
the prevalence of ar is increasing worldwide .
we investigated whether hyeonggaeyeongyo - tang ( hyt ) is effective to suppress the progression of ar induced by ovalbumin ( ova ) .
male balb / c mice were used for this study .
allergic ... |
the prevalence of epilepsy in the general population is estimated to be 40 - 70/1000 people ; people with intellectual disability ( i d ) have a higher rate of epilepsy diagnoses than the general population .
i d was known as mental retardation earlier , and we have used these terms interchangeably in manuscript .
... | background : epilepsy is a disorder that is commonly found in people with intellectual disability ( i d ) .
the prevalence of epilepsy increases with the severity of i d .
the objective of this study was to determine if there is an association between intelligence quotient ( iq ) and epilepsy in children with id.ma... |
gingival - periodontal diseases include a set of pathologies that affect the protective and insertion tissues of teeth .
a wide range of clinical pictures arises from a complex interrelationship among bacterial aggression , intrinsic host response , and risk factors or disease modifiers .
traditional diagnosis is d... | background : oral exfoliative cytology includes the study and interpretation of the features cells exfoliated from the oral mucosa . the aim of this study was to analyze cytological changes in the periodontal pocket of patients with different clinical stages of aggressive periodontitis ( ap ) and chronic periodontitis ... |
in 1996 , mazzaferro et al.1 documented excellent survival results after liver transplantation ( lt ) in a highly selected group of patients with hepatocellular carcinoma ( hcc ) with a single tumor < 5 cm or as many as three tumors , each smaller than 3 cm .
recent studies have shown that selected patients who do ... | macroscopic vascular invasion ( macrovi ) is associated with poor outcomes after liver transplantation ( lt ) for hepatocellular carcinoma ( hcc ) . whether microvascular invasion ( microvi )
is associated with the same adverse prognosis is unclear .
one hundred and fifty - five consecutive patients with confirmed ... |
unstable distal radius fractures requiring surgery have long been treated with diverse techniques including pinning , external fixation , nailing , and plating.12 open reduction and internal fixation with locking distal radius plates have become very popular over the last 10 years.345 however , controversy still exists... | background : controversy still exists regarding the current treatment modalities for unstable distal radius fractures .
there are yet few articles investigating the efficacy of bicolumnar dorsal plating technique , which is designed to minimize tissue dissection while providing sufficiently secure fixation .
a clin... |
informed consents were signed by each patient before cardiac electrophysiology procedure . after ceasing of antiarrhythmic drugs for more than five halflife periods ,
paul , mn 551179983 , usa or japan lifeline co. , ltd , tokyo 1400002 , japan ) were , respectively , inserted into right ventricular apex and coronary... | key clinical messageradiofrequency catheter ablation has been used for treating cardiac arrhythmias , such as premature ventricular contractions and accessory pathway .
we report two cases with successful ablation of leftsided accessory pathways and premature ventricular contractions from mitral annulus with one abla... |
pro - apoptotic signaling is mediated by specific ligands and surface death receptors which are capable of transmitting it from an extra- to an intracellular environment and activating the execution of apoptosis .
death receptors belong to the tumor necrosis factor ( tnf ) family , whose most important members are tn... | fas and its ligand ( fasl ) are known to play a crucial role in the genetically controlled mechanism of cell death , and their deregulation in cancer cells is involved in the immune escape of the tumor .
the aim of this review is to analyze the current knowledge on the prognostic value of fas / fasl in breast cancer ... |
by exploiting the ability of retroviruses to move genes into random sites of mammalian genomes and by exploiting some features of their replication , retrovirus vectors have been developed that select for instances in which the virus integrates into expressed genes . since integrated proviruses tag transcriptionally ac... | |
the brachial plexus consists of nerve roots c5t1 , which mainly innervate the muscles of the upper arm , and control the normal activities of these muscles .
brachial plexus injury , particularly total root avulsion , is one of the most serious disabilities of the extremities .
it has an unfavorable prognosis and m... | in the treatment of brachial plexus injury , nerves that are functionally less important are transferred onto the distal ends of damaged crucial nerves to help recover neuromuscular function in the target region .
for example , intercostal nerves are transferred onto axillary nerves , and accessory nerves are transfe... |
its average annual incidence has been estimated at 48 per 100 000 for deep venous thrombosis and 23 per 100 000 for pulmonary embolism .
the clinical significance of venous thromboembolism is not only because of the risk of death from pulmonary embolism , but also because of the high risk of recurrent events , the oc... | venous thromboembolism is a common disease that is associated with considerable morbidity if left untreated .
recently , low - molecular - weight heparins ( lmwhs ) have been evaluated for use in acute treatment of deep venous thrombosis and pulmonary embolism .
randomized studies have shown that lmwhs are as effec... |
pmn are innate immune cells that migrate from the circulation to sites of infection , where they are responsible for antimicrobial functions .
pmn use phagocytosis , degranulation , and formation of neutrophil extracellular traps ( nets ) to kill microbes [ 2 , 3 ] .
nets are formed through a unique cell death prog... | neutrophils ( pmn ) are the most abundant leukocytes in the blood .
pmn migrate from the circulation to sites of infection , where they are responsible for antimicrobial functions .
pmn use phagocytosis , degranulation , and formation of neutrophil extracellular traps ( nets ) to kill microbes .
nets are fibers c... |
minimally invasive gynecologic surgery ( migs ) for gynecologic malignancies was initially challenged regarding safety and efficacy .
discussions of port - site metastasis ( psm ) questioned whether surgeon technical skill , port - site tumor extraction , local surgical seeding of port - sites , or pneumoperitoneum c... | a 71-year - old woman with suspected endometrial cancer underwent robotic - assisted hysterectomy , bilateral salpingo - oophorectomy , pelvic and para - aortic lymph node dissection , and infracolic omentectomy revealing a stage ii uterine carcinosarcoma with components of serous adenocarcinoma and undifferentiated sp... |
malnutrition from loss of appetite , indigestion , malabsorption , and metabolic problems is a common condition in cancer patients undergoing treatment .
side effects of chemotherapy include anemia , appetite loss , dysgeusia , changes in sensitivity to food temperature , constipation , diarrhea , dysphagia , xerosto... | in this case study , the process of nutritional diagnosis and intervention conducted at a hospital on a malnourished patient who underwent treatment for a chronic illness ( chemotherapy for cancer treatment ) was recorded .
the patient received his first round of chemotherapy for colorectal cancer , and then a second... |
trata - se de uma prtica antiga e teve seu primeiro relato em 1913 , mas , por conta dos eventos adversos decorridos de sua utilizao inadequada , como o uso de solues hipertnicas , a prtica passou a ser inutilizada .
essa pratica tem sido utilizada em pacientes que apresentam diagnsticos de desidratao moderada em raz... | the aim of this study was to analyze the information available in the literature about the drugs that can be administered through hypodermoclysis and the resulting impact that this information may have on the routine of the pharmacist working at a hospital .
the study was based on a review of the literature .
the r... |
secondary amyloidosis ( aa ) can occur during the dynamic progression of chronic rheumatic diseases such as rheumatoid arthritis ( ra ) , juvenile idiopathic arthritis ( jia ) , ankylosing spondylitis and psoriatic arthritis [ 15 ] . despite recent progress in the treatment of aa
the prospective disease progression o... | summarybackgroundsecondary amyloidosis is a frequently reported complication of rheumatoid arthritis .
currently , accepted diagnostic protocols for secondary amyloidosis involve histopathological and histochemical examinations of collected tissue specimens .
the purpose of the current report was to evaluate the va... |
it is a state of increased vulnerability to poor resolution of homoeostasis after a minor stressor event , which increases the risk of adverse outcomes , including falls , delirium , disability , long - term care , and death [ 1 , 2 ] . between a quarter and half of people older than 85 years
for older community resi... | the aim was to apply awgs criteria to estimate the prevalence of sarco - osteoporosis and investigate its relationship with frailty , in a sample of 316 community - dwelling chinese older people .
regression analysis was performed using frailty as the dependent variable .
the results showed that the prevalence rate... |
polycyclic aromatic
hydrocarbons ( pahs ) are characterized by the
presence of two or more fused benzene rings arranged in various configurations .
pahs are ubiquitous airborne environmental pollutants
that arise from the incomplete combustion of fossil fuels and are
also present in automobile exhaust and fir... | polycyclic
aromatic hydrocarbons ( pahs ) are environmental and tobacco
carcinogens .
proximate carcinogenic pah trans - dihydrodiols
are activated by human aldo - keto reductases ( akrs ) to yield electrophilic
and redox - active o - quinones .
interconversion among
benzo[a]pyrene ( b[a]p)-7,8-dione ,
... |
lysosomal cysteine proteases , the cathepsins , classified as clan c1,1 were long believed to be responsible for the terminal protein degradation in the lysosomes .
this view has changed since they are involved in a number of important cellular processes , such as antigen presentation,2 bone resorption,3 apoptosis4 a... | cystatins comprise a large superfamily of related proteins with diverse biological activities .
they were initially characterised as inhibitors of lysosomal cysteine proteases , however , in recent years some alternative functions for cystatins have been proposed .
cystatins possessing inhibitory function are membe... |
the study sample consisted of 39 nw ( bmi < 85th% for age and sex ) , 64 ob ( bmi 95th% for age and sex ) , and 17 obese adolescents with type 2 diabetes , who were participants in our national institutes of health funded k24 grant of insulin resistance in childhood and had complete data relevant to this investigati... | objectivewe compared acylcarnitine ( acylcn ) species , common amino acid and fat oxidation ( fox ) byproducts , and plasma amino acids in normal weight ( nw ; n = 39 ) , obese ( ob ; n = 64 ) , and type 2 diabetic ( n = 17 ) adolescents.research design and methodsfasting plasma was analyzed by tandem mass spectrometry... |
idiopathic eruptive macular pigmentation ( iemp ) is a rare skin disorder characterized by the presence of asymptomatic , brown pigmented macules that involve the face , trunk and proximal extremities in children and adolescents . the first description of this condition was given by degos et al . ,
these hyperpigment... | we present a case of an otherwise healthy 10-year - old girl who presented with asymptomatic brown macules over the trunk and proximal extremities , of three months duration .
the cutaneous examination revealed multiple , dark brown , discrete , round to oval macules and a few mildly elevated lesions over the trunk a... |
methicillin resistant staphylococcus aureus ( mrsa ) is one of the most common pathogens responsible for hospital infections and , as recently discovered , also for community acquired infections .
it can cause a broad spectrum of infections through local invasion , toxin mediated diseases to generalized infections . ... | in the present study we have analyzed the impact of modified mrsa screening of carriers and patients on epidemiological situation of mrsa during 20082010 , comparing two regional hospitals with similar bed numbers and similar ward profiles in northern poland . in 2008 the proportion of mrsa to all s. aureus isolates wa... |
the history of psychiatry describes the medicalization processes and the mechanisms by which society has emarginated diversity and has always been imbued with the attitudes which mental health institutions and services have had towards the patients families .
the advent of psychotherapy and psychoanalysis was the tur... | the family s role in patient care was greatly altered by law 180 .
this law , introduced in italy in 1978 , led to a gradual phasing out of custodial treatment for psychiatric patients .
this different mindset , which views the family as an alternative to institutionalization , leads to it being seen as an essentia... |
we followed the prisma ( preferred reporting items for systematic reviews and meta - analyses ) checklist for reporting systematic reviews and meta - analyses ( 6 ) .
we systematically searched medline , embase , central , cinahl , and web of science through october 2011 for studies in humans of the association betwe... | objectiveavailable evidence supports the emerging hypothesis that metabolic syndrome may be associated with the risk of some common cancers .
we did a systematic review and meta - analysis to assess the association between metabolic syndrome and risk of cancer at different sites.research design and methodswe conducte... |
it is now widely accepted that colorectal cancer ( crc ) arises through the accumulation of genetic and epigenetic changes .
the order as well as the number of events are important in the process that transform normal cells into neoplastic precursors and subsequently into malignant tumors , which may further metastas... | backgroundcolorectal cancer ( crc ) is one of the most common causes of cancer - related deaths in the western world , and despite the fact that metastases are usually the ultimate cause of deaths , the knowledge of the genetics of advanced stages of this disease is limited . in order to identify potential genetic abno... |
study participants were from the chingford study , a well - described prospective population - based longitudinal study of osteoarthritis and osteoporosis , comprising 1,003 women aged 43 years or above at entry , derived from the age / sex register of a large general practice in chingford , north london .
all the w... | our aim was to examine the association between serum dehydroepiandrosterone sulfate ( dheas ) at baseline and bmd change at the femoral neck ( fn ) and lumbar spine ( ls ) in postmenopausal women during a 15-year follow - up .
all participants were from the chingford study .
bmd at the fn and ls were measured eight... |
four - month - old whole - body ampk2 mice ( 29 ) backcrossed to c57bl/6j mice for nine generations , and wild - type littermate controls were fed on either chow , chf , or chf+f diet for nine weeks .
body weight and food consumption were recorded , and edta - plasma and tissues were collected for various analyses as... | objectivethe induction of obesity , dyslipidemia , and insulin resistance by high - fat diet in rodents can be prevented by n-3 long - chain polyunsaturated fatty acids ( lc - pufas ) .
we tested a hypothesis whether amp - activated protein kinase ( ampk ) has a role in the beneficial effects of n-3 lc-pufas.research... |
chromatin compaction represents a barrier for the repair of dna double - strand breaks ( dsbs ) .
however , heterochromatin components are also required for dsb repair by homologous recombination .
the bard1/hp1 interaction , required for the retention of brca1 , ctip , and rad51 at dsb sites , may play a critical ... | |
currently anti - tnf agents are widely used for cutaneous and systemic autoimmune diseases . for dermatologists most common indications for anti - tnf use are psoriasis and psoriatic arthritis .
we describe a case of scedosporium apiospermum infection in a patient receiving long - term treatment with etanercept , a t... | patients on anti - tnf therapy are at increased risk for rare opportunistic infections . here we are reporting a case of scedosporium apiospermum infection in a patient treated with anti - tnf for 5 years .
patients on anti - tnf need close follow - up and clinicians should be suspicious for atypical infections in th... |
forty - four consecutive american society of anesthesiologists ( asa ) classes i - ii adult patients scheduled for elective inguinal hernia repair surgery under spinal anesthesia were included in this prospective randomized controlled clinical trial .
the treatment group was prepared with cho and the control group fa... | background : the aim of this study was to investigate the role of carbohydrate - rich drink ( cho ) on perioperative discomfort , hemodynamic changes , and insulin response in patients undergoing surgery with spinal anesthesia.methods:forty-four adult patients were assigned to one of the two groups of 22 , namely prepa... |
gestational diabetes mellitus ( gdm ) , as a common pregnancy complication , is defined as glucose intolerance with onset or first recognition during pregnancy ( 1 ) .
gdm is associated with adverse perinatal outcome , and increased long - term risks of type 2 diabetes mellitus , metabolic syndrome and cardiovascular... | background : the prevalence of gestational diabetes mellitus ( gdm ) , as a complex problem in pregnancy , is increasing all over the world , but most noticeable in developing countries.aims:to estimate gdm prevalence and associated pregnancy features in the southern part of bosnia and herzegovina.methods:a cross - sec... |
intrahepatic arterial aneurysms are rare and typically related to trauma , transplantation , iatrogenic injury , or infection
we present the case of a 49-year - old man with an intraparenchymal hepatic artery aneurysm that presented as massive hemobilia following a laparoscopic cholecystectomy .
the aneurysm could ... | background : intrahepatic arterial aneurysms are rare and typically related to trauma , transplantation , iatrogenic injury , or infection .
they account for approximately 10% of clinically significant hemobilia.case report : we present the case of a 49-year - old man with an intraparenchymal hepatic artery aneurysm ... |
skeletal tuberculosis ( tb ) accounts for around 3 - 5% of all cases , of which about 10% occurs at the ankle and foot region . in most cases ,
tuberculosis of the foot affected a single bone , and tarsal bones are rarely affected .
diagnoses of these cases are difficult and delayed because of the overlapping and v... | tuberculosis of the foot is an uncommon entity and the reported incidence is 0.1% to 0.3% .
the isolated tuberculosis of talonavicular joint is exceptionally rare . in tuberculosis of the foot and ankle
, the presentation is usually nonspecific .
the diagnosis of tuberculosis affecting foot is difficult , especia... |
local and/or regional analgesic techniques are principal components of many multimodal analgesic techniques , as they have been shown to improve pain relief as well as reduce opioid requirements , thereby reducing the potential for opioid - related adverse events.1 for many superficial and minimally invasive surgical p... | backgroundthis report presents results from four preclinical studies evaluating safety and pharmacokinetics ( pks ) of liposome bupivacaine following intravascular ( intravenous [ iv ] , intra - arterial [ ia ] ) , epidural , and intrathecal administration in dogs.methodsintravascular administration was initially teste... |
transcranial magnetic stimulation ( tms ) of human visual cortex , at an intensity above a distinct threshold , induces illusory visual perceptions called phosphenes [ 13 , 14 ] .
it is thought that phosphenes originate from early visual cortex ( v1/v2 ) [ 1316 ] and depend on the integrity and excitability [ 17 , ... | summaryconscious perception depends not only on sensory input , but also on attention [ 1 , 2 ] . recent studies in monkeys [ 36 ] and humans [ 712 ] suggest that influences of spatial attention on visual awareness may reflect top - down influences on excitability of visual cortex . here
we tested this specifically ,... |
therefore , the purpose of this work is to discuss possibilities and mechanisms of serious and grave multiple complications associated with purulent meningitis ( pneumorrhachis ) . based on the studied case , conclusion and recommendations that would animate the debate on the topic
he was admitted in the emergency de... | pneumorrhachis is the presence of air in the spinal canal ; mostly , it has an iatrogenic origin .
the association of this entity with spontaneous pneumomediastinum without any pneumothorax is rarely reported in the literature .
the spontaneous resorption is the usual evolution .
the association to acute transver... |
an earless kingstar cultivar of muskmelon ( cucumis melo l. ) was cultivated in a greenhouse at jeollabuk - do agriculture research and extension services ( jbares ) , iksan ( latitude : 3558 ' n ; longitude : 1272 ' e ) , from april to august 2009 .
gummy stem blight was observed on the stem and leaf stalk of muskme... | gummy stem blight is a major foliar disease of muskmelon ( cucumis melo l. ) . in this study , morphological characteristics and rdna internal transcribed spacer ( its ) sequences were analyzed to identify the causal organism of this disease .
morphological examination of the jeonbuk isolate revealed that the percent... |
type 2 diabetes defined as non - insulin - dependent or adult - onset diabetes originates from the body 's inability to consume insulin which is frequently accompanied with weight gain and physical inactivity .
as one of the most costly and prevalent chronic diseases worldwide , diabetes is constantly increasing due ... | background .
the present study is the fourth cohort study conducted in the middle east on the evaluation of prediabetes and type 2 diabetes , implemented in ahvaz , iran
. methodology .
the individuals aged over twenty years who had participated in a study on the prevalence of metabolic syndrome in 2009 ( phase 1... |
this study was conducted to evaluate the prophylactic effect of ginger extract on ethanol - induced reproductive toxicity in male rats by measuring the total homocysteine ( thcy ) , trace elements , antioxidant enzymes activity including glutathione peroxidase , superoxide dismutase ( sod ) and catalase , and malondial... | background : ginger is a natural dietary component with antioxidant and anti - carcinogenic properties .
this study was conducted to evaluate the prophylactic effect of ginger extract on ethanol - induced reproductive toxicity in male rats by measuring the total homocysteine ( thcy ) , trace elements , antioxidant en... |
zoonotic trematode infections are public health problems in asian countries , including lao people 's democratic republic ( lao pdr ) , vietnam , thailand , china , and korea .
especially , fishborne trematodes ( fbt ) provoke a remarkable morbidity among local people as well as a serious damage in aquaculture indust... | a survey was performed to investigate the infection status of freshwater fish with zoonotic trematode metacercariae in phnom penh and pursat province , cambodia .
all collected fish with ice were transferred to our laboratory and examined using the artificial digestion method . in fish from phnom penh , 2 kinds of me... |
multiple sclerosis ( ms ) is a chronic inflammatory disease of the central nervous system ( cns ) .
numerous evidences strongly suggest that it is an autoimmune disease in which activated t cells enter the cns and trigger an inflammatory cascade resulting in demyelination and axonal loss .
different genetic and env... | background and objectives .
resistant and susceptible mouse strains to experimental autoimmune encephalomyelitis ( eae ) , an inducible demyelinating experimental disease serving as animal model for multiple sclerosis , have been described .
we aimed to explore mhc - independent mechanisms inducing resistance to ea... |
tuberculosis ( tb ) caused by mycobacterium tuberculosis ( m. tb ) still is a leading cause of morbidity and mortality worldwide .
m. tb infects one - third of the world population ; however , only 10% of them progress to active tb , possibly due to complex environmental , genetic , and immunological interactions .
... | backgroundfindings regarding the association of the single - nucleotide polymorphisms ( snps ) rs4986790 and rs4986791 in toll - like receptor 4 and rs187084 , rs574386 , and rs352139 in toll - like receptor 9 ( tlr9 ) with pulmonary tuberculosis ( ptb ) susceptibility are inconsistent .
we conducted a meta - analysi... |
exercise has long been recognized as a cornerstone of diabetes management and for the prevention of incident diabetes .
although reductions in body weight or achievement of an optimal weight is often a therapeutic goal for individuals with type 2 diabetes mellitus ( t2 dm ) , the benefits of exercise training may be ... | we aimed to compare the level of agreement between leg - to - leg bioelectrical impedance analysis ( lbia ) and dual - energy x - ray absorptiometry ( dxa ) for assessing changes in body composition following exercise intervention among individuals with type 2 diabetes mellitus ( t2 dm ) .
forty - four adults with t2... |
indels ( insertion deletion ) or dips ( deletion insertion polymorphisms ) are short length diallelic polymorphisms , consisting of the presence or absence of short sequences ( typically 150 bp ) .
they are relatively common throughout the human genome representing 1520 % of all polymorphisms with the total num... | the investigator dipplex kit ( qiagen ) contain components for the simultaneous amplification and analysis of 30 biallelic autosomal indels and amelogenin .
the objective of this study was to estimate the diversity of the 30 markers in polish ( np = 122 ) and taiwanese ( nt = 126 ) population samples and to evalu... |
periodontal disease is a chronic inflammatory condition induced by dental biofilm that results in pocket formation , alveolar bone destruction and tooth loss as evidenced by studies in animals and humans .
periodontal disease has been divided in two main categories : gingivitis ( gingival inflammation without loss of... | extensive intraosseous lesions represent a clinical challenge for the periodontist . sites with bone defects
have been shown to be at higher risk of periodontitis progression in patients who had not received periodontal therapy .
thus , the aim of this case report was to describe a novel approach for the treatment ... |
neurocysticercosis is the most common parasitic infection of central nervous system and result from infection with the intermediate stage of taenia solium . in india , cysticercosis is highly prevalent and cns involvement is seen in 60%90% of infested patient .
cerebrum and cerebellum are common sites but may involve... | neurocysticercosis is a common childhood neurological illness in india .
a variety of presentations have been reported in the literature , including weber syndrome .
neurocysticercosis , manifesting as millard gubler syndrome , have not been reported in literature .
therefore , we report a child presented to us w... |
bloodstream recurrent infections have been reported for a great variety of opportunistic bacteria , with coagulase - negative staphylococci being the most common .
the majority of the relapsing sepsis infections are either catheter related or are caused by indwelling devices that serve as an excellent solid phase for... | bloodstream recurrent infections have been reported for a variety of opportunistic bacteria .
these are often either catheter related or are caused by indwelling devices . a case of relapsing sepsis with two escherichia coli strains carrying extended - spectrum -lactamase and derepressed ampc genes
is reported .
... |
our study was performed on the basis of the guidelines set both by the u.s .
national institute of health and the recommendations of the committee on animal research at our institution .
ten pigs ( n = 10 , 30 - 35 kg ) were subjected to 90 minutes of occlusion of the left anterior descending coronary artery , and ... | objectivewe wanted to evaluate the effect of the number of diffusion - sensitizing gradient directions on the image quality for evaluating myocardial anisotropy and fiber tracking by using in vitro diffusion tensor mr imaging ( dt - mri).materials and methodsthe dt - mr images , using a sense - based echoplanar imaging... |
elucidation of protein protein interactions contributes to the characterization of the function of novel proteins and hence the genes that encode them .
methods for investigation of protein protein interactions include biophysical , computational , biochemical and genetic approaches . for the identification of mult... | methods for determining protein protein interactions in mammalian cells typically rely on single reporter functions and are susceptible to variations between samples particularly in regard to levels of transcription , processing and translation .
a method has been developed for determining protein protein interacti... |
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