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shear has estimated about 9% while donath about 4% of dentigerous cysts to occur in the first decade of life . developmental type of cyst develops in a mature tooth as a result of fluid accumulation . inflammatory type develops in an immature permanent tooth as a result of spread of inflammation from an overlying n...
dentigerous cyst may be developmental or inflammatory in origin . the latter is found only in mixed dentition with a low frequency . treatment of inflammatory type of dentigerous cyst in children should be done with the aim of saving developing permanent teeth which should not be sacrificed as far as possible . t...
transcatheter procedures for treatment of diseased heart valves in selected patients are of increasing importance , with promising results following transcatheter aortic valve implantation ( tavi ) . the number of catheter - based isolated aortic valve surgeries in germany tripled from around 2,500 procedures in 2009...
the development of transcatheter techniques for treatment of severe mitral valve regurgitation in the beating heart is focus of recent research . an off - pump treatment technique poses great benefits , particularly for multimorbid patients , often being non - compliant to the gold standard treatment , being open hea...
the nature of the forces involved in partitioning chromosomes has been an active area of research for more than 50 years . edwin taylor and bruce nicklas were among the first to consider the forces that resist chromosome movement . separate theoretical analyses predicted that 0.1 pn would be required to move a chro...
chromosome segregation requires the generation of force at the kinetochore the multiprotein structure that facilitates attachment of chromosomes to spindle microtubules . this force is required both to move chromosomes and to signal the formation of proper bioriented attachments . to understand the role of force in ...
gynoid lipodystrophy , better known as cellulite , is the most common lipodystrophic disease and is found in 85% of post - adolescent women.14 cellulite usually develops in particular anatomical areas , such as the thighs , buttocks , abdomen , and upper arms , and becomes visible through its classical orange peel ap...
backgroundextracorporeal shock wave therapy has been successfully introduced for the treatment of cellulite in recent years . however , it is still unknown whether the individual clinical outcome of cellulite treatment with extracorporeal shock wave therapy can be predicted by the patient s individual cellulite grade a...
secure a wiretrol 5 ul glass capillary tube onto glass micropipette puller and adjust heater and solenoid settings to pull pipette with a smooth , shallow taper . attach a source of positive air pressure onto the end of the pulled micropipette and gently lower the tip of the pipette onto a metal grating surface at a 45...
the walls of the lateral ventricles contain the largest germinal region in the adult mammalian brain . the subventricular zone ( svz ) in these walls is an extensively studied model system for understanding the behavior of neural stem cells and the regulation of adult neurogenesis . traditionally , these studies ha...
anthocyanins belong to a diverse group of secondary metabolites of the phenylpropanoid class , the flavonoids , which are found in different plant species . they represent some of the most important natural pigments , which are responsible for the wide range of red to purple colors present in many flowers , fruits , ...
most of the plant pigments ranging from red to purple colors belong to the anthocyanin group of flavonoids . the flowers of plants belonging to the genus passiflora ( passionflowers ) show a wide range of floral adaptations to diverse pollinating agents , including variation in the pigmentation of floral parts rangin...
antimicrobial resistance is a troubling and growing public health threat . in addition to resistance mechanisms that can develop at the cellular level , the propensity of bacteria to form biofilms further protects them from environmental assaults , including antibiotics and the host immune system . in fact , bacter...
bacterial biofilms underlie many persistent infections , posing major hurdles in antibiotic treatment . here we design and demonstrate tug - of - war optical tweezers that can facilitate the assessment of cell cell adhesion a key contributing factor to biofilm development , thanks to the combined actions of optica...
bracket bonding has some drawbacks including low strength of bracket bond to tooth structure and subsequently high risk of debonding , high risk of plaque accumulation and consequent development of white spot lesions around brackets [ 14 ] . prevention of enamel demineralization around orthodontic brackets is a major...
objectives : this study sought to assess the effect of curcumin nanoparticles ( curcnps ) on antimicrobial property and shear bond strength ( sbs ) of orthodontic composite to bovine enamel.materials and methods : in this in vitro , experimental study , 1% , 5% and 10% curcnps were added to transbond xt composite . s...
hysterosalpingography ( hsg ) , also called uterosalpingography , is a fluoroscopic imaging method that uses an iodinated contrast media to investigate endometrial - uterine morphology and fallopian patency in women with infertility and repeated abortions . hsg can identify many lesions , including hyperplasia , poly...
objectives : presently , hysterosalpingography ( hsg ) is used as a means to evaluate women with infertility and repetitive pregnancy loss . venous intravasation is a complication and potential pitfall during hsg and analogous procedures including hysteroscopy . the aim of our study was to assess the venous intrava...
since its clinical introduction in the 1980s , the high - field magnetic resonance ( mr ) scanners has been progressively developed to improve the signal - to noise ratio ( snr ) and contrast susceptibility for the better human brain images ( 1 , 2 ) . the current use of higher - field mr scanners for brain tumors...
a 45-yr - old female patient was admitted with one - month history of headache and progressive left hemiparesis . brain magnetic resonance imaging ( mri ) demonstrated a mass lesion in her right frontal lobe . her brain tumor was confirmed as a small cell glioblastoma . her follow - up brain mri , taken at 8 months...
the treatment regimen includes multi - agent chemotherapy ( three phases : induction therapy , intensification therapy , maintenance therapy ) and central nervous system directed radiotherapy . immune suppression caused due to disease , and its therapy makes these children more prone to infections with severe stomato...
background : treatment of acute leukemia's- a common childhood malignancy , involves intensive and powerful multi - drug chemotherapeutic regime . oral lesions are a common complication in these patients affecting oral health status.aim:this study was conducted to evaluate and assess the oral health status of newly d...
comprehensive women s healthcare includes basic reproductive health services , such as hormonal contraception , and specialized services , such as infertility evaluation / treatment and prenatal and obstetric care.1,2 as the number of women veterans enrolling in the veterans health administration ( va ) has increased ,...
abstractintroductionwith the increasing number of women veterans enrolling in the veterans health administration ( va ) , there is growing demand for reproductive health services . little is known regarding the on - site availability of reproductive health services at va and how this varies by site location and type....
although our review was protocol - driven , it allowed for evolution as we became more familiar with the literature . we undertook a systematic literature search for relevant empirical and theoretical sources , using electronic databases ( pubmed , cinahl , scopus , psycinfo , sociological abstracts , dissertation ab...
contextone of health care 's foremost challenges is the achievement of integration and collaboration among the groups providing care . yet this fundamentally group - related issue is typically discussed in terms of interpersonal relations or operational issues , not group processes.methodswe conducted a systematic se...
maximal ball release velocity is a crucial variable for successful performance in many sport games such as team handball , baseball , soccer and water polo ( van den tillaar and ettema , 2003 ) . the velocity of the ball in an overarm throw depends on optimal throwing mechanics and body segments characteristics . t...
abstractin the present study , the effect of frequent , immediate , augmented feedback on the increase of throwing velocity was investigated . an increase of throwing velocity of a handball set shot when knowledge of results was provided or not provided during training was compared . fifty female and seventy - thre...
cellular mediated immune responses to brucellosis drive a broad range of manifestations of the disease that vary from subclinical infection ( more common with brucella abortus ) to undulant fever , to focal pyogenic infection , to chronic fatigue syndrome - like illness ( yingst and hoover , 2003 ; yang et al . , 2005 ...
brucella spp . , are gram negative bacteria that cause disease by growing within monocyte / macrophage lineage cells . clinical manifestations of brucellosis are immune mediated , not due to bacterial virulence factors . acquired immunity to brucellosis has been studied through observations of naturally infected ho...
the agency for toxic substances and disease registry ( atsdr ) is a public health agency with responsibility for assessing the public health implications associated with uncontrolled releases of hazardous substances into the environment . the biological effects of low - level exposures are a primary concern in these ...
several studies demonstrate that rats ( rattus novergicus ) infected with protozoan parasite toxoplasma gondii exhibit lesser fear to cat odors . this is thought to increase transmission of the parasite to its definitive hosts , i.e. cats . this is an example of extended phenotype where a gene of an organism allege...
retinitis pigmentosa ( rp ) comprises a heterogeneous group of inherited retinal disorders that primarily affects the rod and cone photoreceptors and provokes a progressive loss of them beginning in the periphery and progressing toward the central retina.13 histopathologic studies on patients with rp have shown earlier...
introductionour purpose was to study the correlation between the macular morphology and function in eyes with retinitis pigmentosa ( rp).methodssixty - six eyes from 33 patients with rp and with different visual acuity ( va ) were studied using optical coherence tomography ( oct ) and multifocal electroretinogram ( mfe...
empowerment as a primary outcome has been considered in most interventions related to women s health , and focusing on other issues has caused the clinical importance of the incensement of empowerment and its subsequent health benefits to be neglected . empowerment of women was designed to develop skills and resource...
abstractbackground : women s empowerment programs during pregnancy focus primarily on increasing women s health goals and psychological empowerment has been considered important in most issues related to pregnant mothers mental health . using path analysis , this study aims to examine the direct and indirect componen...
this study included 189 patients who were diagnosed with mm between 2001 and 2011 at the asan medical center , seoul , korea . disease was considered to be plasmablastic when > 30% of myeloma cells in the bm biopsy exhibited plasmablastic morphology . all patients met the following criteria : bm involvement ; no pr...
backgroundabsolute lymphocyte count ( alc ) in peripheral blood has recently been reported to be an independent prognostic factor in multiple myeloma ( mm ) . previous studies indicated that the absolute monocyte count ( amc ) in peripheral blood reflects the state of the tumor microenvironment in lymphomas . neith...
it is classified into type 1 ( monoclonal due to paraprotein disorders ) , type 2 ( mixed polyclonal and monoclonal secondary to hepatitis c ) , and type 3 ( polyclonal due to lymphoproliferative disorders ) . the most common type described in the literature is secondary to hepatitis c , with a prevalence described a...
cryoglobulinaemia is a systemic inflammatory condition characterised by immune complex - mediated small - to - medium - sized vasculitis . it has a wide variety of presentations ranging from bruising , neuropathy , and hepatosplenomegaly to acute renal failure . mixed cryoglobulinaemia is the most common type and i...
folate is essential to the carbon transfer necessary for dna synthesis , cell division , and tissue growth . the mthfr gene is located at chromosome 1p36.3 and is 2.2 kb in length with a total of 11 exons . within the mthfr gene a common c to t polymorphism exists in exon 4 at position 677 , it is a point mutation ...
background:677c to t allele in the 5 , 10-methylenetetrahydrofolate reductase ( mthfr ) gene has been implicated in the etiology of various syndromes and nonsyndromic diseases but till date no direct studies have been reported with craniosynostosis.objectives:the aim was to study the family - based association of mthfr...
owing to the aging of the global population , the prevention and treatment of chronic diseases in the elderly have become important health issues . the increase in the number of cases of osteoporosis - induced fractures in the elderly is noteworthy.1,2 the world health organization has defined osteoporosis as a disea...
backgroundthe issue of osteoporosis - induced fractures has attracted the world s attention . postmenopausal women are particularly at risk for this type of fracture . the nonmedicinal intervention for postmenopausal women is mainly exercise . whole body vibration ( wbv ) is a simple and convenient exercise . t...
presently in the united states , it is estimated that one in five people will develop some form of skin cancer due to a combination of family history , environment , and genetic factors ( see the american cancer society for more information , http://www.cancer.org/cancer/skincancer-melanoma/detailed guide / melanoma - ...
the global incidence of melanoma has dramatically increased during the recent decades , yet the advancement of primary and adjuvant therapies has not kept a similar pace . the development of melanoma is often centered on cellular signaling that hyper - activates survival pathways , while inducing a concomitant blockade...
he3286 ( 17-ethynylandrost-5-ene-3,7,17-triol ) is a chemical derivative of the natural mammalian sterol androst-5-ene-3,7,17-triol ( aet ) . aet exhibits anti - inflammatory activity in rodent models , is elevated in plasma of obese subjects with normal glucose disposal , and may play a compensatory role in preventi...
obesity - related inflammation - induced insulin resistance and metabolic dysregulation were investigated in retrospective analysis of placebo hematologic and metabolic laboratory data from trials associated with increasing chronic low - grade inflammation and body mass index . studies included healthy subjects and t...
glycogen synthase kinase-3 ( gsk-3 ) is a cmgc serine / threonine protein kinase initially described as one of the kinases that phosphorylates and inhibits glycogen synthase . it is now widely accepted though that gsk-3 plays an important role in various essential physiological processes , such as development , cell ...
glycogen synthase kinase-3 ( gsk-3 ) unique position in modulating the function of a diverse series of proteins in combination with its association with a wide variety of human disorders has attracted significant attention to the protein both as a therapeutic target and as a means to understand the molecular basis of t...
a major goal is to determine what are the biochemical / physiological factors in the wound that can reconstruct the damaged parts more effectively . wound healing is a dynamic interactive process involving many precisely interrelated phases that overlap in time and lead to the restitution of tissue integrity . the ...
a wound is a type of injury that damages living tissues . in this review , we will be referring mainly to healing responses in the organs including skin and the lungs . fibrosis is a process of dysregulated extracellular matrix ( ecm ) production that leads to a dense and functionally abnormal connective tissue com...
an 81-year - old woman recognized pruritic scaly erythemas on the scalp 2 months before the visit to our hospital . her medical history included nephrosis syndrome that had been treated with oral cyclosporine 100 mg / day for 8 years . the results of routine blood work before the onset of skin eruptions had been no...
seborrheic dermatitis is an inflammatory eruption that tends to distribute on the sebaceous areas of the body and is rarely described as a paraneoplasia . here we report a case with a responsive seborrheic dermatitis - like eruption of the head which resulted in generalized erythroderma . intensive examinations det...
n - methyl-2-pyrrolidone ( nmp ) ( fluka , new jersey , usa ) was used as received . sabouraud dextrose agar ( sda ) , sabouraud dextrose broth ( sdb ) , tryptic soy agar ( tsa ) and tryptic soy broth ( tsb ) ( difco , usa ) were used as media for antimicrobial test . the 20% w / w lf127 solutions containing 10 , 2...
the purpose of this study is to investigate the effects of n - methyl-2-pyrrolidone on the thermosensitive properties of aqueous ethylene oxide - propylene oxide block copolymer ( lutrol f127 ) system . due to the aqueous solubility enhancement and biocompatibility , n - methyl-2-pyrrolidone is an interesting solubil...
paracoccidioidomycosis ( pcm ) appears to be caused by a complex group of fungi within the paracoccidioides genus comprising four distinct phylogenetic lineages known as ps2 , ps3 , s1 , and pb01-like ( carvalho et al . based on clinical and genetic studies , the pb01 isolate differs from the other strains and has be...
paracoccidioidomycosis ( pcm ) is an endemic latin american mycosis caused by paracoccidioides brasiliensis and also by the recently described p. lutzii . the systemic mycosis is the 10th leading cause of death due to infectious diseases in brazil . as published , 1,853 patients died of pcm in the 19962006 decade i...
bacterial infection can evoke shock , acute respiratory failure , multiple organ failure , and disseminated intravascular coagulation ( dic ) , resulting in a high mortality rate . lipopolysaccharide ( lps ) , a major component of the outer membrane of gram - negative bacteria , initiates the cascade of pathophysiolo...
urinary trypsin inhibitor ( uti ) , a serine protease inhibitor , has been widely used in japan as a drug for patients with acute inflammatory disorders such as disseminated intravascular coagulation ( dic ) , shock , and pancreatitis . recent in vitro studies have demonstrated that serine protease inhibitors may hav...
lumbar foraminal stenosis ( lfs ) is a condition seen in degenerative lumbar spinal disorders in which a nerve root or spinal nerve is entrapped in a narrowed lumbar foramen . there is a dorsal root ganglion that functions as a pain receptor at this site making this condition refractory and likely to cause severe low...
objectiveit is important to develop an easy means of diagnosing lumbar foraminal stenosis ( lfs ) in a general practice setting . we investigated the use of the japanese orthopaedic association back pain evaluation questionnaire ( joabpeq ) to diagnose lfs in symptomatic patients.methodssubjects included 13 cases ( m...
allergic conjunctivitis is a complex disorder that significantly contributes to the burden of misery and economic impact resulting from environmental allergies , especially in those patients who are either untreated or ineffectively treated.1 allergic conjunctivitis is reported to affect approximately 15% to 20% of the...
purpose : results from 2 patient - reported outcome studies of allergic conjunctivitis sufferers who used olopatadine 0.2% and azelastine 0.05% are analyzed.methods:the pace ( pataday allergic conjunctivitis evaluation ) multi - center , prospective , open - label study examined patient perceptions of olopatadine 0.2% ...
a 43-year - old female patient was diagnosed with osteonecrosis of the right femoral head and therefore was treated with core decompression and replacement of tantalum trabecular metal system ( zimmer , parsippany , nj , usa ) about 5 months ago in soonchunhyang university cheonan hospital . the patient was in a late...
although the incidence of sciatic nerve palsy following total hip arthroplasty is low , this complication can cause devastating permanent nerve palsy . the authors experienced a case of sciatic nerve palsy caused by ruptured and contracted external rotator muscles following total hip arthroplasty in a patient sufferi...
chronic infection with hepatitis c virus ( hcv ) is a global health problem affecting a significant proportion of world s population . the world health organization estimated that in 1999 there were 170 million hcv carriers worldwide , with 34 million new cases appearing each year . a 48-week course of peg - ifn- w...
highlights we modeled drug responses using decision tree learning based on snps in a genome - wide association study . we can predict the drug responses of a new patient with hcv genotype 1 . responsiveness to pegylated interferon ( peg - ifn- ) plus rebavirin ( rbv ) treatment was predicted . we can predict wit...
opioids have been increasing in usage and play an important role in every aspect of modern anesthesia . among opioids , fentanyl , alfentanil , sufentanil , and remifentanil are commonly chosen for analgesia , sedation , hemodynamic stability , as well as attenuation of stress response during anesthesia . however ,...
pain is difficult to investigate and difficult to treat , in part , because of problems in quantification and assessment . the use of opioids , combined with classic anesthetics to maintain hemodynamic stability by controlling responses to intraoperative painful events has gained significant popularity in the anesthe...
salmonellosis due to nontyphoidal salmonella ( nts ) infection is a global public health concern , particularly in salmonella endemic low and middle income countries ( lmics ) . treatment is critical for persons with severe disease , particularly children and immune compromised people . treatment with an appropriat...
salmonellosis , an acute invasive enteric infection , is endemic in bangladesh . we analyzed 128,312 stool samples of diarrheal patients to identify salmonella spp . during 20052013 . a total of 2120 ( 1.7% ) salmonella spp . were isolated and the prevalence of salmonella spp . decreased significantly over time (...
basal cell carcinoma ( bcc ) is defined by the world health organization committee on the histological typing of skin tumors as a locally invasive , slowly spreading tumor which rarely metastasize , arising in the epidermis or hair follicles and in which , in particular , the peripheral cells usually simulate the bas...
basal cell carcinoma ( bcc ) is a malignant neoplasm derived from nonkeratinizing cells that originate from the basal layer of the epidermis and is the most frequent type of skin cancer in humans , with cumulative exposure to ultraviolet radiation as an important risk factor . bcc occurs most frequently at sun - expo...
twenty to forty - five percent of patients with advanced cancer suffer from moderate to severe pain that requires treatment with opioids [ 13 ] . pharmacokinetic aspects of morphine and metabolites have been extensively studied and it has been shown that there are large inter - individual differences in serum concent...
objectiveoxycodone is widely used for the treatment of cancer pain , but little is known of its pharmacokinetics in cancer pain patients . the aim of this study was to explore the relationships between ordinary patient characteristics and serum concentrations of oxycodone and the ratios noroxycodone or oxymorphone / ...
osgood - schlatter disease ( osd ) is a well known condition , characterized by pain over the tibial tubercle with subsequent tubercle prominence . we report an unusual case of simultaneous bilateral tibial tubercle avulsion fracture in a 16 year old boy who was a known case of osd . a 16 year old boy a known case ...
introduction : osgood - schlatter disease ( osd ) is a well known condition , characterized by pain over the tibial tubercle with subsequent tubercle prominence . avulsion fracture following osd is a rare complication . we report an unusual case of simultaneous bilateral tibial tubercle avulsion fracture in a 16 ye...
the macarthur foundation 's research network on successful midlife development says that midlife is perhaps the most ill - defined of any period in life . until recently it could really be so puzzling that many people are confused and fail to understand this natural event of life . however , it could also be a time...
background : between the school years of 2009 - 2012 , the turnover record of the university of san jose - recoletos ( usj - r ) , cebu city , philippines showed that permanent faculty members who left the institution were all midlifers . their reasons varied from health issues to greener pasture elsewhere.materials ...
the constellation of findings consisted of a solid ovarian mass , ascites and hydrothorax , which should be considered as a malignant process until proven otherwise . however , in 1937 , meigs and cass1 ) reported the clinical picture of nonmalignant ascites and/or pleural effusion in association with a benign ovaria...
herein , a rare case of ovarian granulosa cell tumor , presenting as meigs ' syndrome , with elevated carbohydrate antigen 125 ( ca125 ) , is reported . a 69-year - old woman was admitted for the investigation of abdominal fullness and dyspnea . a preoperative examination revealed a huge pelvic tumor and an abdomin...
incidence and mortality of neonatal - acquired brain damage , especially hypoxic - ischemic brain damage ( hibd ) , have an increasing trend . brain damage of prematurity is the predominant form of the acquired brain damage in neonates who undergo neurological morbidity . administration of the recombinant human - ery...
background : recombinant human - erythropoietin ( rh - epo ) has therapeutic efficacy for premature infants with brain damage during the active rehabilitation and anti - inflammation . in the present study , we found that the rh - epo was related to the promotion of neovascularization . our aim was to investigate whe...
nanotechnology was incorporated in an estimated us$82 billion worth of manufactured goods in 2008 , according to currall 1 and appeared in over 800 consumer products on the market.2 pre - global financial crisis estimates were that nanotechnology would be in us$2.6 trillion worth of goods by 2014.3 yet despite this rap...
public debate on nanotechnology is a large topic within governments , research agencies , industry and non - government organisations . but depending who you talk to the perception of what the public thinks about nanotechnology can be very varied . to define coherent policy and to invest in research and development t...
robust data assessing the value of procalcitonin ( pct ) for monitoring treatment response in abdominal sepsis are rare , so the study of jung and colleagues published in the previous issue of critical care is most welcome . they concluded that a decrease of pct to 0.5 ng / ml lacked sensitivity to predict treatment...
the ideal management of infection includes not only the early identification and start of effective therapy but also the correct categorization of non - infected patients in order to avoid unnecessary use of antimicrobials . the availability of a specific and sensitive test for the presence of infection is of paramou...
increased pollution from rapid industrialization and increases in the smoking rate are gradually focusing public attention on respiratory disorders . breathing , the major function of the lung , is the process that alternately performs inspiration and expiration with gas exchange that is essential for humans li...
[ purpose ] the purpose of this study was to identify changes in pulmonary function and pulmonary strength according to time of day . [ subjects and methods ] the subjects were 20 healthy adults who had no cardiopulmonary - related diseases . pulmonary function and pulmonary strength tests were performed on t...
the prevalence of intestinal parasitic infection is high in sub - saharan africa , where the majority of hiv / aids cases are from [ 2 , 3 ] . diarrhea causing opportunistic parasites like cryptosporidium parvum and isospora belli is common among hiv positive persons with cd4 count less than 200 cells/l [ 4 , 5 ] . ...
background . intestinal parasitic infection affects the health and quality of life of people living with hiv . this study was aimed to determine the prevalence of intestinal parasites among hiv positive individuals who are naive and who are on antiretroviral treatment ( art ) in hiwot fana specialized university ho...
recent advances in technology now permit the clinician to measure dynamic lip - tooth relationships and incorporate that information into the orthodontic problem list and treatment plan . digital photography along with videography is useful in both smile analysis and patient communication . there are two types of s...
objective : the present study is intended to add a new parameter that would be useful in orthodontic clinical evaluation , treatment planning , and determination of vertical dimension ( at occlusion).materials and methods : standardized videographic recording of 79 subjects during posed smile was captured . each vide...
acinic cell carcinomas ( acc ) are usually low grade , uncommon neoplasms constituting 2.54% of parotid gland tumors . papillary cystic variant ( pcv ) of acc is a rare tumor , the diagnosis of which is based on histopathological examination . it is composed of tumor with papillary and cystic growth patterns , with...
acinic cell carcinoma ( acc ) is an uncommon low - grade tumor of the salivary glands that constitutes 2.54% of parotid gland tumors . papillary cystic variant ( pcv ) of acc is even rarer and can be diagnosed on histopathological examination only . it is important to diagnose this variant as it carries a poor prog...
as the number of applicants to medical schools always exceeds the number of available places , there has to be a means of selecting candidates for those places . applicants are usually well qualified and highly motivated . the task of selection and rejection is always challenging , and fraught with uncertainty . ap...
the appropriate selection of medical students is a challenging task . it requires that important assessment criteria principally based upon cognitive skills that include the matriculation and admission test scores of the applicants be fulfilled . non - cognitive skills are also important , but used to a lower degre...
atopic dermatitis ( ad ) is a chronic and recurrent disease which concerns 1020% of population . the onset of ad is usually before 2 years old , and in approximately 60% of the patients skin lesions of different intensity remain for the whole life . ad is characterized by typical morphology and distribution of sk...
atopic dermatitis ( ad ) is an inflammatory skin disease in which pathogenesis chemokines are partially involved . the aim of the paper was to assess the serum level of cxcl-9 , cxcl-10 , cxcl-11 , cxcl-12 , ccl-17 , ccl-20 , ccl-21 , ccl-22 , ccl-27 , a...
the knowledge of medicinal plants in india has been accumulated in course of many centuries based on several ancient medicinal systems , including ayurveda , unani and siddha . according to the survey report of world health organization , india , one of the richest floristic regions of the world has diverse socio - e...
aim : the present study was aimed at exploring the indigenous knowledge of native tribes on the utilization of wild plant species for local healthcare management in malda district of west bengal.materials and methods : successive field surveys were carried out from july 2012 to august 2013 in search of traditional heal...
allosteric regulation is a key mechanism whereby proteins respond to environmental stimuli that modulate their activity . classic models of allostery ( e.g. , the mwc and knf models ) suggest that a binding event at an allosteric site induces substantial conformational changes in the primary catalytic site . ...
allostery can occur by way of subtle cooperation among protein residues ( e.g. , amino acids ) even in the absence of large conformational shifts . dynamical network analysis has been used to model this cooperation , helping to computationally explain how binding to an allosteric site can impact the behavio...
certain marine algae produce potent toxins that impact human health through the consumption of contaminated shellfish and finfish and through water or aerosol exposure . over the past three decades , the frequency and global distribution of toxic algal incidents appear to have increased , and human intoxications from...
insights into the toxicity caused by the intracellular accumulation of mutant serpins largely comes from work on 1-antitrypsin deficiency , the best characterized of the serpinopathies . 1-antitrypsin is synthesized in the liver and is constitutively released into the circulation where it protects tissues against dam...
members of the serpin ( serine proteinase inhibitor ) superfamily play a central role in the control of inflammatory , coagulation , and fibrinolytic cascades . point mutations that cause abnormal conformational transitions in these proteins can trigger disease . recent work has defined three pathways by which thes...
studies focusing on protein interfaces have revealed that binding energies are not uniformly distributed along the protein interfaces . instead , there are certain critical residues called hot spots. these residues comprise only a small fraction of interfaces yet account for the majority of the binding energy ( 13 ) ...
we present a new database of computational hot spots in protein interfaces : hotsprint . hot spots are residues comprising only a small fraction of interfaces yet accounting for the majority of the binding energy . hotsprint contains data for 35 776 protein interfaces among 49 512 protein interfaces extracted from ...
in the last decade , the increased use of microarrays for global expression analyses made large - scale transcript analyses possible . using publicly available microarray datasets , several studies showed that genes with similar function tended to be transcriptionally coordinated ( stuart et al . , 2003 ; ihmels et...
global transcript analyses based on publicly available microarray dataset have revealed that genes with similar function tend to be transcriptionally coordinated . indeed , many genes involved in the formation of cellulose , hemicelluloses , and lignin have been identified using co - expression approaches in arabidop...
ena / vasp proteins regulate cell migration by promoting actin polymerization at the plasma membrane via antagonizing actin filament capping and acting as processive actin polymerases ( barzik et al . , 2005 ; bear et al . , 2002 ; breitsprecher et al . , 2008 , 2011 ; hansen and mullins , 2010 ; pasic et al . , 20...
summaryena / vasp proteins and the wave regulatory complex ( wrc ) regulate cell motility by virtue of their ability to independently promote actin polymerization . we demonstrate that ena / vasp and the wrc control actin polymerization in a cooperative manner through the interaction of the ena / vasp evh1 domain with ...
francisella tularensis causing zoonotic infectious disease " tularemia " is gram - negative facultative non - motile intracellular coccobacillus bacteria considered as a potential bioterrorism agent because subspecies tularensis classified as type a is a high - risk pathogen which can cause severe symptoms when infecte...
tularemia is a high - risk infectious disease caused by gram - negative bacterium francisella tularensis . due to its high fatality at very low colony - forming units ( less than 10 ) , f. tularensis is considered as a powerful potential bioterrorism agent . vaccine could be the most efficient way to prevent the ci...
roughly 40 years have passed since permanent pacemakers ( pms ) became available in clinical medicine . more recently , implantable cardioverter - defibrillators ( icds ) and cardiac resynchronization therapy ( crt ) have been introduced . the rate of device implantation is increasing with the aging of the general ...
backgroundlead extraction using laser sheaths is performed mainly for cardiac implantable electronic device ( cied ) infections . however , there are few reports concerning the management of cied infections in japan.methods and resultslead extraction procedures were performed in 183 patients targeting 450 leads ( atr...
this prospective study followed the principles of the declaration of helsinki and was approved by the hospital ethical committee , and all participants signed a standard informed consent form reporting the potential risks and benefits of the procedure and subsequent management . all patients were confirmed by the oph...
purpose : to observe the effect of prophylactic intraocular pressure ( iop)-lowering medication ( brinzolamide ) on iop after ranibizumab intravitreal injections ( ivis).materials and methods : this prospective case control study included 352 eyes from 352 patients ( 1 eye per patient ) who were treated with ranibizu...
etiological factors for spinal epidural hematoma are tumors , anticoagulant therapy , coagulopathy , hypertension , arteriovenous malformations , and trauma . most common presentation is sudden back or neck pain followed by a motor or sensory dysfunction with or without urinary retention . complete neurological rec...
spontaneous spinal epidural hematoma is very uncommon cause of spinal cord compression . it is extremely rare in children and is mostly located in dorsal epidural space . ventral spontaneous spinal epidural hematoma ( sseh ) is even rarer , with only four previous reports in childrens . we are reporting fifth suc...
glaucoma comprises a number of different pathomechanisms leading to a specific degeneration of the retinal ganglion cells and changes in the optic nerve head . primary open angle glaucoma is the most common form and affects about 1% of the western population . to date , the only defined risk factors for the develop...
since the pathomechanisms of primary open angle glaucoma are still not defined , different aspects related to this topic have to be discussed and further investigated . possible candidates are the mineralocorticoids , which are known to lower intraocular pressure . a data search and personal investigations assume a...
schwannoma is a benign tumor arising from neuroectodermal schwann cell of cranial , intraspinal , peripheral and autonomic nerve sheaths . lesions in head and neck region account for 25 - 45% of extra - cranial schwannomas . however , it rarely involves infra - orbital nerve and are uncommon in the maxillary and bu...
extra - cranial schwannomas although common in head and neck region are very rarely seen originating from the infra - orbital nerve . we report a case of schwannoma arising from infra - orbital nerve in a 40-year - old male patient . the case presented as an isolated , asymptomatic , slow growing sub - cutaneous no...
thyroid cancer is a common endocrine malignancy that has rapidly increased in global incidence in recent decades . in the united states , the 6.6% average annual increase in thyroid cancer incidence between 2000 and 2009 is the highest among all cancers . although the death rate of thyroid cancer is relatively low ...
backgroundseveral studies have evaluated the association between obesity and thyroid cancer risk . however , the results remain uncertain . in this study , we conducted a meta - analysis to assess the association between obesity and thyroid cancer risk.material/methodspublished literature from pubmed , embase , spr...
systemic lupus erythematosus ( sle ) is a severe systemic autoimmune disease and , as such , is characterized by a loss of self - tolerance . the etiology of sle is not well defined , but genetic , hormonal , and environmental factors , as well as immune disorders , are likely implicated . during sle , inflammation l...
systemic lupus erythematosus ( sle ) is a chronic autoimmune disease characterized by b cell hyperactivity leading to the production of autoantibodies , some of which having a deleterious effect . reducing autoantibody production thus represents a way of controlling lupus pathogenesis , and a better understanding of ...
hypertension is a multifactorial condition characterized by high and sustained levels of blood pressure ( bp ) . it is the most common condition in primary care and often associated with functional and/or structural changes in target organs and metabolic disorders , increasing the risk of fatal and nonfatal cardiovas...
poor eating habits may represent cardiovascular risk factors since high intake of fat and saturated fatty acids contributes to dyslipidemia , obesity , diabetes mellitus , and hypertension . thus , nutritional interventions are recognized as important strategies for primary prevention of hypertension and as adjuvants...
the determinants of physical activity ( pa ) in patients with copd are poorly understood . a recent systematic review identified several clinical , functional , sociodemographic , and lifestyle factors associated with pa in these patients , but the quality of evidence was low to very low , mainly due to the use of a ...
backgroundthe role of anxiety and depression in the physical activity ( pa ) of patients with copd is controversial . we prospectively assessed the effect of symptoms of anxiety and depression on pa in copd patients.methodswe evaluated anxiety and depression ( hospital anxiety and depression scale [ hads ] ) , pa ( d...
human immunodeficiency virus ( hiv ) infection and acquired immune deficiency syndrome ( aids ) affect all aspects of human endeavors as they cut across age , gender , race , socio - political status , education , relation , ethnic , culture , and barriers of any kind . as in 2005 , about 43 million have been infecte...
background : students are pivotal to manpower development and technological advancement of any nation . nigerian nation was recently ranked third human immunodeficiency virus ( hiv ) most endemic nation in the worldaim : the study was designed to determine the frequency of hiv infection among nigerian tertiary and se...
it has been reported that over 400 million people are obese worldwide , and the number is projected to reach 700 million by 2015.1 according to the reports from the international association for the study of obesity , approximately one - fourth of european men and women are obese and approximately one - half of europea...
previous reports indicate that over 13 different tumors , including hepatocellular carcinoma ( hcc ) , are related to obesity . obesity - associated inflammatory , metabolic , and endocrine mediators , as well as the functioning of the gut microbiota , are suspected to contribute to tumorigenesis . in obese people , ...
early - stage tuberculous ( tb ) meningitis has no specific symptoms , which may lead to delayed diagnosis and consequently to a worsened prognosis . tb meningitis with dementia as the presenting symptom after intramedullary spinal cord tumor resection without meningitis symptoms or positive tests for tb has not been...
abstractearly - stage tb meningitis has no specific symptoms in patients , potentially leading to delayed diagnosis and consequently worsening prognosis . the authors present the fatal case with a delayed diagnosis of tuberculous ( tb ) meningitis with dementia as the presenting symptom after intramedullary spinal co...
when a 72-year - old white male with ms heard the doorbell ring he manually opened the door . a visitor entered the residence and introduced himself as a gal who is a paid state employee appointed by a judge . the ms patient responded that he would not have time to talk to the gal because he had been scheduled at a...
the children of a multiple sclerosis ( ms ) patient filed a guardian ad litem case to be brought against the patient . the basis for the petition was that the ms patient had a significant reduction is his mental competence . the children were not aware that hyperthermia could adversely affect the brain of ms patien...
through development , the wiring of the cortex is refined to receive and establish both local ( callaway , 1998 ; fino and yuste , 2011 ; ktzel et al . , 2011 ; ko et al . , 2011 ; kozloski et al . , 2001 ; yoshimura et al . , 2005 ) and long - range ( berezovskii et al . , 2011 ; salin and bullier , 1995 ) pr...
summarysensory computations performed in the neocortex involve layer six ( l6 ) cortico - cortical ( cc ) and cortico - thalamic ( ct ) signaling pathways . developing an understanding of the physiological role of these circuits requires dissection of the functional specificity and connectivity of the underlying indi...
the incidence of renal cell carcinoma is consistently increasing , and the increase in use of imaging technologies has resulted in an increase in the incidental detection of renal cell carcinoma , especially of small renal masses . nephron - sparing surgery has become the standard treatment for small renal masses , d...
purposecurrent clinical data support a safe warm ischemia time ( wit ) limit of 30 minutes during laparoscopic partial nephrectomy ( lpn ) or robot - assisted partial nephrectomy ( rpn ) . we evaluated independent factors predicting prolonged wit ( more than 30 minutes ) after lpn or rpn.materials and methodsa retros...
physical activity is very important for health and helps to protect from many chronic diseases . in addition to its contribution to development of motor skills , it is necessary for socialization and self - confidence , especially in childhood and adolescence . many guidelines commonly state that children between t...
backgroundthis study investigated participation in physical education and sports lessons of visually impaired adolescents and their sighted peers and compared their physical activity levels.material/methodsa total of 22 visually impaired children of mean age 13.591.14 years and 31 sighted children aged 13.610.50 years ...
caspase-2 is one of the closest mammalian homologues of the caenorhabditis elegans caspase ced-3 and shares significant homology with the drosophila nedd2-like caspase ( dronc ) , both of which are essential for developmentally programmed cell death [ 1 - 4 ] . although several studies have implicated caspase-2 as a ...
caspase-2 is the most evolutionarily conserved of caspase family members , yet its physiological function has remained unclear and is a matter of considerable debate . newly published data now suggest that caspase-2 is required for cell cycle regulation , repair of damaged dna , and in suppressing myc - induced lymph...
endothelial keratoplasty ( ek ) in the forms of descemet stripping automated endothelial keratoplasty ( dsaek ) and descemet membrane endothelial keratoplasty ( dmek ) has revolutionised corneal transplantation for the treatment of endothelial dysfunction and is the procedure of choice in such cases , as it carries sev...
purpose . to compare the surgical outcomes of staged and combined phacoemulsification with intraocular lens implant ( phaco+iol ) and descemet stripping automated endothelial keratoplasty ( dsaek ) in patients with fuchs ' endothelial dystrophy and cataract . setting . corneoplastic unit and eye bank , queen victor...
natural products derived from the medicinal plants are used across the globe as pharmaceutical drugs , cosmetics , fertilizers , insecticides , and pesticides . the overexploitation of medicinal plants is a threat to their existence with several taxa becoming extinct . alternate sources of important metabolites hav...
endophytes , the microbes residing within the plant tissues , are important sources of secondary metabolites . tabernaemontana heyneana wall . , a medicinal tree , endemic to the western ghats with rich ethnobotanical history and unique chemical diversity , was selected to study fungal endophytes and evaluate them...
railway accidents are one of the major concerns of worldwide traffic safety that impact global public health strategies . recent statistics reports from the european union show a slightly declining trend in train accidents observed since 2004 , in all european states . nevertheless , in the eu-27 for 2011 , romania...
aimsinternational research highlights the occupational risk of train drivers of being exposed to work related traumatic incidents and subsequently developing posttraumatic symptoms or other comorbid dysfunctions.participants and methodsthe article focuses on investigating the effects of repeated traumatic exposure on p...
sarcoidosis is a systemic granulomatous disease of unknown origin , characterized by the presence of noncaseating granuloma in affected organs ( 1 ) . lesions are commonly seen in the lungs , lymphatic system , eyes , skin , liver , spleen , salivary glands , heart , nervous system , muscles , and bones ( 1 , 2 ) . ...
we report a case of 54-yr - old woman who presented with 4-extremities weakness and sensory changes , followed by cervical spinal cord lesion in magnetic resonance imaging . based on the suspicion of spinal tumor , spinal cord biopsy was performed , and the histology revealed multinucleated giant cells , lymphocytes ...
deep vein thrombosis ( dvt ) and pulmonary embolism is a serious yet preventable cause of postoperative morbidity and mortality . it is estimated that 20 million cases of lower extremity dvt occur in the usa alone and account for the vast majority of pulmonary embolism each year.1 major orthopedic surgeries of the lo...
background : the venous stasis of soleal vein during surgery may be an important factor in the development of deep vein thrombosis ( dvt ) . the stimulation of calf muscle during surgery may help in preventing dvt . the present study is conducted to evaluate the role of peroperative calf muscle electrostimulation in pr...
micrornas ( mirnas ) are short noncoding regulatory molecules , involved in diverse biological processes . biogenesis of mirnas involve a nuclear phase , where the microprocessor complex , comprising drosha , an rnase iii - like enzyme and its cofactor dgcr8 , process primary mirnas ( pri - mirnas ) into a 70 nt pre ...
summarydrosha is the main rnase iii - like enzyme involved in the process of microrna ( mirna ) biogenesis in the nucleus . using whole - genome chip - on - chip analysis , we demonstrate that , in addition to mirna sequences , drosha specifically binds promoter - proximal regions of many human genes in a transcripti...
kassebaum et al1 reported that the annual rate of change in the maternal mortality ratio was greater than 1% between 2003 and 2013 , with the most substantial improvement from 2012 to 2013 at 3.3% . many of the global gains in reducing maternal mortality can be attributed to developments in preventing and treating po...
backgrounda myriad of interventions exist to treat postpartum hemorrhage ( pph ) , ranging from uterotonics and hemostatics to surgical and aortic compression devices . nonetheless , pph remains the leading cause of maternal mortality worldwide . the purpose of this article is to review the available evidence on th...
chromobacterium violaceum is a gram negative , rod shaped , nonsporing , and motile bacteria that can utilize carbohydrate fermentatively and grows readily on the ordinary laboratory culture media at 35c37c.1 it naturally resides in soil and stagnant water of tropical and subtropical regions as saprophyte2 and produces...
chromobacterium violaceum is a gram negative saprophytic bacterium , prevalent in tropical and subtropical climates . infections caused by c. violaceum are very uncommon , yet it can cause severe systemic infections with higher mortality when entered into the bloodstream through open wound . a case of symptomatic bac...
both lipoprotein glomerulopathy ( lpg ) and fibrillary glomerulonephritis ( fgn ) are rare causes of end - stage renal disease ( esrd ) . lpg is a rare disease of renal lipoidosis , first described by saito et al . in 1989 . to date , 150 cases of lpg have been reported in the literature , with most of them in japa...
both lipoprotein glomerulopathy ( lpg ) and fibrillary glomerulonephritis ( fgn ) are rare causes of end - stage renal disease ( esrd ) , and the literature concerning the outcome of kidney transplant in patients with lpg or fgn is scarce . we report a patient who suffered from esrd with coexisting fgn and lpg and re...
malaria is one of the most common parasitic infections in the developing countries and cerebral malaria ( cm ) is one of the most common causes for non - traumatic encephalopathy in the world . malaria is caused by five species of plasmodium namely plasmodium vivax , plasmodium falciparum , plasmodium malariae , plas...
introduction : cerebral malaria ( cm ) is one of the most common causes for non - traumatic encephalopathy in the world . it affects both the urban and rural population . it is a challenge to treat these patients in a resource limited setting ; where majority of these cases present.materials and methods : this was ...
the term click chemistry describes a collection of organic reactions that proceed rapidly and selectively under mild conditions to covalently link molecular components.(1 ) among the many click reactions described to date , the huisgen 1,3-dipolar cycloaddition of azides and alkynes(2 ) has received the most attentio...
the 1,3-dipolar cycloaddition of azides and activated alkynes has been used for site - selective labeling of biomolecules in vitro and in vivo . while copper catalysis has been widely employed to activate terminal alkynes for [ 3 + 2 ] cycloaddition , this method , often termed click chemistry , is currently incom...
mutations in the tyrosine kinase domain of the epidermal growth factor receptor ( egfr ) gene have been identified in non - small cell lung carcinoma ( nsclc ) , and they were correlated with clinical response to egfr tyrosine kinase inhibitor ( tki ) treatment . patients with egfr mutations have a higher response r...
purposemutation - specific antibodies have recently been developed for identification of epidermal growth factor receptor ( egfr ) mutations by immunohistochemistry ( ihc ) . this study was designed to investigate whether the type of specimen ( biopsy vs. resection ) would make a difference in determining mutation st...
human chorionic gonadotropin ( hcg ) is a heterodimeric hormone secreted by the trophoblastic tissue of the placenta as well as certain tumors . small amounts of hcg have been reported to be secreted by the pituitary gland in non - pregnant females and males . various commercial assays are available in the market t...
women are often subjected to serum human chorionic gonadotropin ( hcg ) testing prior to diagnostic and therapeutic interventions . a positive result leads to further testing to rule out pregnancy and avoid possible fetal teratogenicity . the impact of chronic kidney disease ( ckd ) on hcg testing has not been stud...
mechanical peripheral neuropathies are the consequence of local or extrinsic compression phenomena or impingement by an anatomic neighbor causing a localized entrapment . traumatic neuropathies are the result of either closed injuries or open injuries to peripheral nerves [ 1 , 2 ] . both of these categories are ch...
neuropathic syndromes which are evoked by lesions to the peripheral or central nervous system are extremely difficult to treat , and available drugs rarely joint an antihyperalgesic with a neurorestorative effect . n - palmitoylethanolamine ( pea ) exerts antinociceptive effects in several animal models and inhibits ...
the stress - induced cardiomyopathy ( scm ) is characterized by acute , reversible , and transient left ventricular ( lv ) systolic dysfunction mimicking acute coronary syndrome without significant stenosis on coronary angiogram.1)2 ) this syndrome was first described by satoh et al.3 ) and was named takotsubo - cardio...
background and objectivesstress - induced cardiomyopathy ( scm ) is characterized by a transient left ventricular ( lv ) dysfunction due to emotional and physical stress . there are limited data about the clinical characteristics in korean patients . we sought to clarify the clinical features and prognosis in patie...
previous studies indicate that there is a higher prevalence of dental anomalies in children with a cleft condition than in the general population . studies have also demonstrated that both genetics and the surgical repair of the palate influence the occurrence of dental anomalies in the cleft population . anomalies...
objective : the purpose of this paper was to describe the prevalence and type of dental anomalies in the primary and permanent dentition in children with a cleft condition at princess margaret hospital in perth , western australia.materials and methods : the details of 162 current dental patients extracted from the mai...
posterior reversible encephalopathy syndrome ( pres ) is a rare , poorly understood disease with a number of associated factors but no clearly delineated etiology . of described cases , it is estimated that greater than one third of patients will never regain baseline neurologic function . the physiologic causes fo...
posterior reversible encephalopathy syndrome ( pres ) is an unusual disease of unknown incidence and cause . there are a wide range of associated , predisposing medical causes to include pregnancy , renal failure , immunosuppressive medication administration and hypertension . the diagnosis is made following the ra...
leptin as a neuroendocrine hormone has effects on the glucose metabolism , sexual maturation , reproduction , pituitary - adrenal axis , immune system , thyroid , and growth hormones level [ 36 ] . probably this hormone is an important risk factor in carcinogenesis , because obesity itself can promote tumorgenesis an...
introduction . leptin as an adipose - tissue - related peptide hormone contributes to the control of food intake , energy expenditure , and other activities such as cell proliferation . therefore , association of leptin level with thyroid cancer has been suggested recently . considering that thyroid cancer is the...
the uterus has been considered an organ adjusting and controlling the important physiological functions , pregnancy , childbirth , a sexual organ , a source of energy , and an organ maintaining the attractiveness and beauty of women . moreover , it comprises an important part of women s self - image , and loss of ute...
background : regarding the contradictions about positive and negative effects of hysterectomy on women s sexual functioning , this study was conducted to review the studies on the effect of hysterectomy on postoperative women s sexual function.method:this study was a narrative review and performed in 5 steps : a ) dete...
almost 263,020 oral cavity cancers , and 127,654 oral cancer deaths occur worldwide each year . on january 1 , 2010 , in the us there were around 275,193 women and men alive who had a history of oral and oro - pharyngeal cancer ( 181,084 men and 94,109 women ) . the 5-year survival rate of patients with oral ca...
objectives oral cancer ( oc ) may be preceded by clinically evident oral potentially malignant disorders ( opmds ) . oral carcinogenesis is a multistep process that begins as epithelial hyperplasia and progresses to oral epithelial dysplasia and finally to fully malignant phenotypes . the aim of our study was to es...
it has been recognized since at least as early as the mid-1500s that inhaled minerals ( i.e. , inorganic particles ) can pose a risk . extensive research has focused on the biological mechanisms responsible for asbestos- and silica - induced diseases , but much less attention has been paid to the mineralogical proper...
induced parturition in cows may have several technological and medical advantages over spontaneous delivery , such as avoiding unattended night - time calving , providing colostrum to the newborn in time , preventing dystocia caused by relative fetal oversize , dealing with fetal deformities , and hydroallantois . ca...
the incidence of retained placenta ( rp ) in cows increases in cases of parturition induced by prostaglandin f2. we analyzed the effects of different doses of supplemental selenium and vitamin e on the incidence of rp , blood selenium , plasma thyronines , and malondialdehyde concentration . thirty - three clinically...
management of ao type c3 distal femur fractures with multifragmentary articular involvement is challenging , with most series reporting average to poor results and frequent complications such as malunion , knee stiffness , and secondary osteoarthritis.1234567891011 only a few studies123456 have exclusively reported the...
background : complex ao type c3 fractures of the distal femur are challenging injuries , fraught with complications such as malunion and stiffness . we prospectively evaluated a consecutive series of patients with complex ao type c3 distal femur fractures to determine the clinicoradiological outcome after fixation wi...
the oxidation of alkanes to alcohols or ketones and the dehydrogenation of alkanes to alkenes are both widely studied targets for c h bond functionalization . for example , the oxidation of cyclohexane to a mixture of cyclohexanol and cyclohexanone is a large - scale commercial process for the production of ...
we report copper - catalyzed oxidative dehydrogenative carboxylation ( odc ) of unactivated alkanes with various substituted benzoic acids to produce the corresponding allylic esters . spectroscopic studies ( epr , uv vis ) revealed that the resting state of the catalyst is [ ( bpi)cu(o2cph ) ] ( 1-o2cph )...