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the available evidence suggests that a sizable proportion of undergraduate health sciences students lack good study skills and habits , and that introducing a study skills program could significantly improve students confidence and academic achievement .
the undergraduate pharmacy degree programs of the university of... | it aimed to compare the study skills of two groups of undergraduate pharmacy students in the school of medicine , university of zambia using the study skills assessment questionnaire ( ssaq ) , with the goal of analysing students study skills and identifying factors that affect study skills .
a questionnaire was dist... |
establish a database of ent , audiology , and speech therapy services in sub - saharan africa.create an awareness in the first world about the status of these services.plan and promote effective , targeted support for these services.gather data to lobby african governments , donor countries , and aid organizations.dete... | backgroundburden of disease ( bod ) is greatest in resource - starved regions such as africa . even though hearing disability ranks third on the list of non - fatal disabling conditions in low- and middle - income countries , ear , nose , and throat ( ent ) disorders are not specifically coded for within the framework ... |
the online version of this article ( doi:10.1007/s12576 - 014 - 0350 - 7 ) contains supplementary material , which is available to authorized users .
after muscle injury or change of use , repair starts with an initial acute inflammatory response ( typically from 0 to 48 h ) followed by a repair and regeneration pha... | in mouse models , ccaat enhancer - binding protein beta ( cebpb ) is necessary for m2 macrophage - mediated regeneration after muscle injury . in humans , cebpb expression in blood
was strongly associated with muscle strength . in this study
we aimed to test whether cebpb expression in blood in people is increased ... |
biomarkers are molecules that represent a pathological signature that is easily identified and quantified for a particular disease or disorder . in recent years
biomarkers have proven essential in identifying individuals at risk for disease , tracking disease progression , and selection of therapeutic intervention . ... | parkinson s disease ( pd ) is a prevalent neurodegenerative illness that is often diagnosed after significant pathology and neuronal cell loss has occurred .
biomarkers of pd are greatly needed for early diagnosis , as well as for the prediction of disease progression and treatment outcome . in this regard ,
the ep... |
pancreatic cancer is a common gastrointestinal cancer , and the incidence and mortality has been increasing in recent years . in the usa , it has been the fourth leading cause of death . in 2009 ,
approximately 42 000 new patients were diagnosed , and 35 000 americans died of pancreatic cancer . .
early diagnosis i... | backgroundsome epidemiological studies have suggested that vitamin e intake reduces the risk of pancreatic cancer ; however , this conclusion has not been supported by all the published studies .
we conducted a meta - analysis to assess the relationship between vitamin e intake and the risk of pancreatic cancer by co... |
acquired pure red cell aplasia ( prca ) is a rare , generally chronic condition of profound anemia characterized by a severe reduction in the number of reticulocytes in the peripheral blood and the virtual absence of erythroid precursors in the bone marrow .
these include :
drugs - phenytoin , trimethoprim , zidovu... | pure red cell aplasia ( prca ) is a known entity in clinical medicine .
patients are often transfusion dependent for their whole life .
ascertaining its etiology is always a herculean task .
we received a similar transfusion - dependent patient , who on evaluation was found to have thymoma as an etiological facto... |
magnetic resonance myelography ( mrm ) has been developed to evaluate the spinal subarachnoid space non - invasively .
in addition , advantages of mrm as compared to conventional or computed tomography ( ct ) myelography are that it does not involve the use of intrathecal contrast or radiation.[14 ] on the heavily t2... | objective : to validate the additional merits of two - dimensional ( 2d ) single thick - slice magnetic resonance myelography ( mrm ) in spinal imaging.materials and methods:2d single thick - slice mrm was performed using t2 half - fourier acquisition single - shot turbo spin - echo ( haste ) sequence in addition to ro... |
enzymes of the eukaryotic protein kinase superfamily phosphorylate serine , threonine or tyrosine residues in proteins .
protein kinases and their substrates form complex networks that regulate essentially every eukaryotic cellular process ( 1 )
. defects in phosphorylation networks result in numerous disease state... | the predikin webserver allows users to predict substrates of protein kinases .
the predikin system is built from three components : a database of protein kinase substrates that links phosphorylation sites with specific protein kinase sequences ; a perl module to analyse query protein kinases and a web interface throu... |
ret ( rearranged during transfection ) encodes a membrane receptor tyrosine kinase ( rtk ) composed of four extracellular cadherin - like motifs and a cysteine - rich region , a transmembrane portion , and an intracellular domain with tyrosine kinase activity . the ret signaling pathways are outlined in ( figure 1 ) . ... | the significance of ret in thyroid cancer comes from solid evidence that , when inherited , an ret activating mutation primes c - cells to transform into medullary carcinomas .
moreover , environmental exposure to radiation also induces rearranged transforming ret
isoforms that are found in papillary thyroid cance... |
bile duct cancer has been associated with a poor prognosis ; node metastasis is a particularly important poor prognostic factor [ 16 ] . despite advances in the diagnosis and treatment of cholangiocarcinoma , such as endoscopic biliary drainage , surgical procedures , and chemotherapy , long - term outcomes
several r... | abstract
a 61-year - old female underwent right hemihepatectomy and caudate lobectomy for hilar cholangiocarcinoma in 1999 .
ten years later , increasing serum carbohydrate 19 - 9 was detected by routine follow - up .
subsequent positron emission tomography revealed an asymptomatic lesion in the right 11th rib . ... |
silica is a toxicant that can stimulate cells to produce various cellular products such as free radicals , cytokines , and growth factors .
silica and its induced substances may induce apoptosis to regulate the evolution of silica - induced inflammation and fibrosis . to examine this hypothesis ,
groups of wistar m... | |
the estimated prevalence has been reported from 16.8% to 58%.15 frequent drooling may cause skin maceration and infection , body fluid loss , and recurrent pneumonia.6,7 at school and at home , children with salivary secretions may cause damage to books , teaching materials and furniture , and it even interferes with s... | objectiveto investigate the association between drooling in children with cerebral palsy ( cp ) and their health - related quality of life ( hrqol ) , as well as the possible variables that predict their hrqol.methoda cross - sectional design was used for this study .
children with cp , without other identified disea... |
this study was conducted under the ethical guidelines for medical and health research involving human subjects by the health , labor and welfare ministry of japan ( http://www.mhlw.go.jp/stf/seisakunitsuite/bunya/hokabunya/kenkyujigyou/i-kenkyu/ ) . according to number 6 ( omission of procedures concerning informed con... | backgroundhuman epidermal growth factor receptor 2 ( her2 ) testing of samples from recurrent or metastatic breast cancer is recommended by the 2013 update of the american society of clinical oncology / college of american pathologists guidelines .
although cytological analysis can be applied to several types of meta... |
the transamidase complex catalyzes the glycosylphosphatidylinositol ( gpi ) lipid anchor attachment to substrate proteins of eukaryotes in the lumen of the endoplasmic reticulum ( er ) .
it remains one of the poorly understood macromolecular machines , both with regard to the molecular function of its many subunits ,... | the transamidase subunit gaa1/gpaa1 is predicted to be the enzyme that catalyzes the attachment of the glycosylphosphatidyl ( gpi ) lipid anchor to the carbonyl intermediate of the substrate protein at the -site .
its ~300-amino acid residue lumenal domain is a m28 family metallo - peptide - synthetase with an / hydr... |
stage iiia endometrial cancer represents a wide range of tumor involvement , including the uterine serosa , adnexa , parametria , and peritoneal space , based on the staging system of the international federation of gynecology and obstetrics ( figo ) in 1988 [ 1 - 3 ] .
in addition , the heterogeneity of histology , ... | purposewe evaluated the role of adjuvant therapy in stage iiia endometrioid adenocarcinoma patients who underwent surgery followed by radiotherapy ( rt ) alone or chemoradiotherapy ( ctrt ) according to risk group.materials and methodsa multicenter retrospective study was conducted including patients with surgical stag... |
hydatid disease ( hd ) , which is caused by echinococcus granulosus , is a common parasitic infestation especially in endemic regions such as the middle east , mediterranean , and south american countries . even though it mainly involves the liver , it has been reported in nearly all parts of the body .
the incidence... | echinococcosis is a helminthic zoonosis mainly caused by echinococcus granulosus and commonly encountered in endemic areas .
the liver and lung are the most frequently involved organs . a primary isolated hydatid cyst of spleen is an extremely rare disease even in endemic areas .
anaphylactic reaction is a known co... |
regional odontodysplasia ( ro ) is a rare developmental dental anomaly that involves ectoderm and mesoderm derived tissues .
the prevalence of this condition is still not clear since the studies reported till date have mainly been based on case reports .
although several factors such as local trauma , infection , i... | regional odontodysplasia ( ro ) is a rare developmental anomaly involving both mesodermal and ectodermal components in primary or permanent dentition .
it affects the maxilla and the mandible or both ; however , maxilla is more commonly involved .
this article reports the case of 33-month - old boy who came with th... |
genomic instability , a key hallmark of cancer , is driven in part by oncogene - induced dna replication stress ( drs ) .
specifically , in cancer cells , activated oncogenes induce dissociation of the replication machinery from the dna fork ( fork collapse ) , formation of dna double - strand breaks ( dsbs ) , and g... | summaryhuman cancers are characterized by the presence of oncogene - induced dna replication stress ( drs ) , making them dependent on repair pathways such as break - induced replication ( bir ) for damaged dna replication forks . to better understand bir
, we performed a targeted sirna screen for genes whose deplet... |
boronic acids and their
derivatives are versatile reagents in modern
organic synthesis , and the hydroboration reaction is a well - established
method for generating these building blocks through the addition of
b
first described by hurd in
1948 and later developed in detail by brown , this reaction has ins... | for nearly 70 years , the addition
of boron x bonds
to carbon
carbon multiple bonds has been employed in the preparation
of organoboron reagents . however , the significantly higher strength
of boron
oxygen bonds has thus far precluded their activation
for addition , preventing a direct route to access ... |
with the rising proportion of older adults and increases in life expectancy , there has been increased interest in maintaining and promoting cognitive health in later life .
although declines in some domains of cognition are part of the natural course of aging [ 2 , 3 ] , sufficient evidence from prospective and obse... | engagement in cognitively stimulating activities has been considered to maintain or strengthen cognitive skills , thereby minimizing age - related cognitive decline .
while the idea that there may be a modifiable behavior that could lower risk for cognitive decline is appealing and potentially empowering for older ad... |
israel s center for disease control seasonal influenza surveillance system operated throughout our 5-year study .
the system is based primarily on 1 ) anonymous patient visits for influenza - like illnesses ( ili ) to maccabi community clinics , israel s second largest health maintenance organization , insuring 1 of ... | during the pandemic ( h1n1 ) 2009 outbreak in israel , incidence rates among children were 2 higher than that of the previous 4 influenza seasons ; hospitalization rates were 5 higher .
children hospitalized for pandemic ( h1n1 ) 2009 were older and had more underlying chronic diseases than those hospitalized for sea... |
with the enactment of section 2991 of the social security amendments of 1972 ( public law 92 - 603 ) , full medicare coverage was extended to persons with end stage renal disease ( esrd ) , effective july 1 , 1973 . to be eligible for medicare esrd benefits ,
the patient must first be currently or fully insured , be ... | a synopsis is given between the relationship of the number of end stage renal disease ( esrd ) patients to the total medicare population and their associated expenditures .
the aging trend within the esrd population is examined in terms of enrollment statistics and incidence ( new cases ) counts .
also , longitudin... |
the online version of this article ( doi:10.1007/s00125 - 010 - 1741 - 9 ) contains a list of members of adag study group , which is available to authorised users .
current understanding of normoglycaemia is largely based on studies of populations without diabetes , often with a small number of glucose measurements p... | aims / hypothesisreal - life glycaemic profiles of healthy individuals are poorly studied .
our aim was to analyse to what extent individuals without diabetes exceed ogtt thresholds for impaired glucose tolerance ( igt ) and diabetes.methodsin the a1c - derived average glucose ( adag ) study , 80 participants without... |
nowadays , with technological advances in medicine , the use of invasive procedures and injections in patients has expanded . as a result
, health care staffs are exposed to a high risk of blood - borne pathogens ( 1 ) .
needle stick injury ( nsi ) is one of the most dangerous occupational situations ( 2 ) . among ... | backgroundinjuries caused by sharp objects , which involve biological hazards are considered as one of the most important factors that lead to stress among the nursing staff .
contact with sharp objects is a major concern among healthcare workers , especially nurses.objectivesthis study was done to determine the amou... |
ultracold polar molecules are attracting
considerable attention ,
and their investigation will extend our knowledge on the physics of
ultracold quantum gases into new regimes .
a very interesting class of molecules in this regard is represented
by mixed alkali alkaline earth ( ak ake ) molecules with
both... | we report on the formation of mixed
alkali alkaline earth
molecules ( lica ) on helium nanodroplets and present a comprehensive
experimental and theoretical study of the ground and excited states
of lica .
resonance enhanced multiphoton ionization time - of - flight
( rempi - tof ) spectroscopy and laser i... |
the purposes of this study were to determine the normal retinal microvasculature measurements in human infants who are born at term and to determine whether birth weight influences measurements of retinal microvasculature .
retinal arteriole and venule measurements were obtained in a cohort of 24 infants who were bor... | objective : the purposes of this study were to determine the normal retinal microvasculature measurements in human infants who are born at term and to determine whether birth weight influences measurements of retinal microvasculature.study design : retinal arteriole and venule measurements were obtained in a cohort of ... |
the possibility of controlling the motion of a robotic arm by mere thought , as suggested by popular media since the advent of brain - machine interfaces ( bmis ) , has captured the imagination of fiction writers and science journalists .
but is mind control a reasonable or even a desirable practical goal for the f... | brain - machine interfaces ( bmis ) are mostly investigated as a means to provide paralyzed people with new communication channels with the external world .
however , the communication between brain and artificial devices also offers a unique opportunity to study the dynamical properties of neural systems .
this re... |
gardner and richard in their landmark article described a syndrome consisting of hereditary intestinal polyposis , with osteomas and multiple cutaneous and subcutaneous lesions .
after that other dental findings , skin and soft - tissue tumors have been added in the description of this syndrome .
the documented fre... | gardner 's syndrome is an autosomal dominant disease characterized by the presence of colonic polyposis , osteomas , and a multitude of soft - tissue tumors .
dental anomalies are present in estimated 30% of all affected individuals of gardner 's syndrome , so dental professionals play an important role in determinin... |
severe alpha 1-antitrypsin ( aat ) deficiency ( pizz ) is an autosomal , codominant , hereditary disorder characterized by low aat levels in the serum and lungs .
the main function of aat is to inhibit neutrophil elastase and other serine proteases , including proteinase-3 and plasmin activator.1 this genetic defect ... | backgroundsevere alpha 1-antitrypsin deficiency ( pizz ) predisposes to morbidity and mortality due to early - onset emphysema and liver disease .
the risk of death from other causes , including cardiovascular disease and cancer , has not been well investigated .
we aimed to analyze cause - specific mortality in pi... |
a 9-year - old female patient reported complaining of pain in the upper front tooth since 3 days .
there was a history of trauma to the same tooth due to fall about 4 days back . on clinical examination ,
periapical radiograph showed incomplete root formation with wide open apices for the same tooth [ figure 1 ] . ... | the completion of root development and closure of the apex occurs up to 3 years after the eruption of the tooth .
the treatment of pulpal injury during this period provides a significant challenge for the clinician .
the importance of careful case assessment and accurate pulpal diagnosis in the treatment of immatur... |
a literature search using relevant terms such as zn and animal feed , bacteria , ( antibiotic resistance or antimicrobial resistance ) , requirement , bioavailability using the advanced search builder provided by pubmed ( www.ncbi.nlm.nih.gov/pubmed ) or web of science was performed . a similar search using the same t... | farmed animals such as pig and poultry receive additional zn and cu in their diets due to supplementing elements in compound feed as well as medical remedies . enteral bacteria in farmed animals are shown to develop resistance to trace elements such as zn and cu .
resistance to zn is often linked with resistance to m... |
study population and sample preparation : one hundred and 24 human subjects
were included in the dog - contact risk factor group . in detail , the dog - contact risk factor
group was composed of 41 dog owners and 43 veterinarians who regularly contact dogs . in this
group , 12 veterinarians who were themselves ... | abstracthelicobacter spp . may have multiple routes of transmission .
it
is unclear , however , whether the agent is zoonotic and therefore transmitted from an
animal reservoir , including dogs .
the aim of this population - based study was to assess the
relationship between pet ownership or frequent exposure... |
the search for an ideal restorative material is a challenge for which dentistry has yet to find a solution .
thus , for each individual clinical situation , dentists must consider certain properties in order to identify the most suitable material .
such properties include biocompatibility , adhesion to the dental s... | with the aim of assessing the performance of brazilian and imported glass ionomer cements ( gic ) with regard to microleakage , 40 primary molars received two standard class ii cavity preparations with margins in enamel .
twenty cavities were filled with brazilian materials ( vidrion r and vidrion rcaps ) and the oth... |
this manifestation , widely known as post - operative cognitive dysfunction ( pocd ) , is characterized by disordered thinking and impaired consciousness with later onset and fluctuating course [ 24 ] .
pocd , as mentioned above , is common in elderly patients , and probably has a pathogenesis similar to that of ad a... | leptin plays a critical role in neuronal development and also promotes structural and functional activities in the central nervous system .
recent studies have demonstrated that leptin could produce therapeutic effects for cognitive impairments of patients with alzheimer s disease ( ad ) .
post - operative cognitiv... |
in the mid-1970s , acute myocardial infarction ( ami ) was identified as being the result of a ruptured atherosclerotic plaque , causing thrombosis and occlusion of the coronary artery .
randomized trials have indicated that primary percutaneous coronary intervention ( ppci ) during the early hours of ami offers cert... | backgroundthis study was aimed to determine whether the grade of ischemia can predict the success of reperfusion in patients treated with thrombolytic therapy ( tt ) for st elevation myocardial infarction ( stemi).material / methodswe enrolled 229 consecutive patients with diagnosis of stemi and receiving tt .
patien... |
endodontic irrigants should have , amongst other properties , a broad antimicrobial
spectrum of activity against anaerobic and facultative micro - organisms growing in
biofilms and a relative absence of toxicity against periapical tissues and oral
mucosa .
sodium hypochlorite ( naocl ) is recommended as the mai... | ideally root canal irrigants should have , amongst other properties , antimicrobial
action associated with a lack of toxicity against periapical tissues . sodium
hypochlorite ( naocl )
is a widely used root canal irrigant , however it has been shown
to have a cytotoxic effect on vital tissue and therefore it is... |
the chemical and physical properties of serpentine and amphibole asbestos are considered in the context of their interaction with tissue of the tracheobronchial tree and lungs . in vitro studies in cultures of several types
are evaluated and work with the erythrocyte hemolysis system is reviewed . although fibers of ... | |
pediatric cerebral aneurysms are rare . according to a recent review by rao et al . , these aneurysms constitute 2.9% of all cerebral aneurysms .
incidence of these aneurysms in pediatric patients is more in the posterior circulation than in the anterior , when compared to the aneurysms in adults .
lasjunias et al ... | aneurysms in the pediatric age group are rare and have preponderance for the posterior circulation .
these aneurysms are more commonly large , giant , and complex .
we present two case reports of saccular aneurysms in pediatric patients who were treated successfully by endovascular technique . |
long chain polyunsaturated fatty acids ( lcpufa ) including docosahexaenoic acid ( dha ) and arachidonic acid ( ara ) , are essential for normal growth , vision , neurodevelopment and overall health . in utero lcpufa accretion
occurs primarily during the last trimester of pregnancy , when maternal levels are high and... | long chain polyunsaturated fatty acids ( lcpufa ) including docosahexaenoic acid ( dha ) , are essential for normal vision and neurodevelopment .
dha accretion in utero occurs primarily in the last trimester of pregnancy to support rapid growth and brain development .
premature infants , born before this process is... |
the laser radiation produces many different effects depending on light - beam parameters as well as the tissues that are subjected to irradiation . despite documented therapeutic effect of low - level laser therapy ( lllt ) , there is still much controversy and scientific debate over its effectiveness [ 13 ] .
the va... | growth factors as vascular endothelial growth factor ( vegf ) , produced by the endothelial cells , take an essential part in pathological and physiological angiogenesis .
the possibility of angiogenesis modulation by application of laser radiation may contribute to the improvement of its use in this process .
thus... |
the extraction of impacted third molars , which may be prophylactic or therapeutic , is one of the most frequently performed operative procedures in oral and maxillofacial surgery.12 surgical extraction of impacted third molars inevitably results in trauma to soft and hard tissues ; consequently , significant pain , sw... | background : the aim of the study was to evaluate the effect of preoperatively administered submucosal and oral prednisolone on postoperative pain , facial swelling , and trismus following third molar surgery.patients and methods : this was a randomized controlled trial in which subjects were randomly distributed into ... |
penaeid prawns are important subjects of mariculture and coastal fisheries activities throughout the tropics and subtropics [ 13 ] .
traditionally , prawn farms located near the coast used directly coastal seawater to rear the prawns without additional processes .
shrimp culture is therefore potentially affected by... | this study analyzed the changes in metallothionein - like proteins ( mtlps ) and energy reserves ( ers ) in hepatopancreas and abdominal muscle of the white prawn penaeus vannamei .
realistic metal concentration exposure for 10 days to ni and pb in solution revealed that juvenile prawns partially induce mtlp in hepat... |
the multiple myeloma is a hematological malignancy characterized by the development of a clone of plasma tumor invading hematopoietic marrow . in its usual form , it involves bone marrow plasma cell infiltration , a monoclonal immunoglobulin in blood and/or urine , and bone involvement .
meningeal localization of mye... | key clinical messagea patient with multiple myeloma with a mass in the nasopharyngeal was diagnosed .
he received melphalan autograft and radiotherapy , and obtained complete remission .
he relapsed 3 months later , with meningeal involvement and without systemic relapse .
he received intrathecal and systemic ch... |
the flash electroretinogram ( erg ) provides an excellent noninvasive means to assess retinal function .
the largest feature of this response is the b - wave , which follows the initial negative a - wave .
the b - wave corresponds to the granit 's pii component and is believed to be generated by the activity of o... | the most dominant feature of the electroretinogram , the b - wave , is thought to reflect on - bipolar cell responses .
however , a number of studies suggest that the b - wave is made up of several components .
we consider the composition of the rat b - wave by subtracting corneal negative components obtained using... |
cat scratch disease ( csd ) is a self - limiting disease in immunocompetent patients .
other bartonella spp . known to cause systemic and ocular manifestation are bartonella quintana , bartonella grahamii , and bartonella elizabethae.1,2 csd
is transmitted to humans through a cat scratch , cat bite , cat saliva , o... | we report a case series of neuroretinitis in ocular bartonellosis and describe the serologic verification for bartonella henselae .
this is a retrospective interventional case series of four patients who presented in the ophthalmology clinic of hospital universiti sains malaysia from june 2012 to march 2013 .
all f... |
disposing the 3d structure of small drug - like molecules can be critical for several computational approaches such as in silico screening ( 1,2 ) , either ligand - based ( 35 ) or receptor structure - based ( 69 ) employed prior to or to complement experimental screening for hit identification , lead optimization or c... | frog is a web tool dedicated to small compound 3d generation . here
we present the new version , frog2 , which allows the generation of conformation ensembles of small molecules starting from either 1d , 2d or 3d description of the compounds . from a compound description in one of the smiles , sdf or mol2 formats
,... |
highly chemoselective
direct reduction of primary , secondary , and
tertiary amides to alcohols using smi2/amine / h2o is reported .
the reaction proceeds with c
n bond cleavage
in the carbinolamine intermediate , shows excellent functional group
tolerance , and delivers the alcohol products in very high yi... | |
screening with mammography has been shown to reduce mortality from breast cancer [ 1 , 2 ] . however , the sensitivity to non - palpable cancer of screening mammography in radiographically dense - breasted women is as low as 3048% .
extremely dense - breasted women have an 18-fold increase in interval cancer found be... | objectiveradiologist reader performance for breast cancer detection using mammography plus automated whole - breast ultrasound ( awbu ) was compared with mammography alone.methodsscreenings for non - palpable breast malignancies in women with radiographically dense breasts with contemporaneous mammograms and awbu were ... |
uveitis , especially noninfectious uveitis , is more common in women than in men , in most large surveys , presumably because of the greater frequency of autoimmune diseases in women .
sex - determined biological variations in type or intensity of response to infections may exist , just as they appear to exist in non... | current data permit only speculations regarding sex differences in the prevalence of infectious uveitis between women and men because uveitis case surveys do not uniformly report gender data .
differences in prevalence that are reported in the literature could relate to simple differences in the number of women and m... |
the incidence of malignant melanoma in fair - skinned patients has increased dramatically in most parts of the world over the past few decades . because the prognosis of melanoma depends almost entirely on tumor thickness , early detection of thin melanoma is important for the survival of patients [ 1 , 2 ] .
the dia... | size functions and support vector machines are used to implement a new automatic classifier of melanocytic lesions .
this is mainly based on a qualitative assessment of asymmetry , performed by halving images by several lines through the center of mass , and comparing the two halves in terms of color , mass distribut... |
in recent years , nursing staff shortages have become a major challenge for health care systems around the world , including iran . in 2008 , iranian hospitals needed approximately 220,000 nurses ; nonetheless , there were just about 90,000 nurses .
this shortage is related to decreased satisfaction among nurses and ... | background : one of the most important challenges of iranian health care system is quality of care , and it is assumed that motivated nurses are more ready to provide better care .
there are limited studies investigating iranian nurses motivations ; however , factors which motivate them have not been studied yet . ... |
urodynamic testing has greatly improved our diagnostic capabilities for patients with complex neurogenic bladder dysfunction . however , despite years of refinements in technical standards and recommendations , urodynamics require experience - based individual interpretation and lack established sensitivity and specifi... | introduction .
the diagnosis of detrusor - external sphincter dyssynergia ( desd ) is a clinically relevant finding during urodynamic testing .
however , there is no consensus regarding diagnostic specifics of electromyography ( emg ) or voiding cystourethrography ( vcug ) .
we evaluated the concordance of the tw... |
with the widespread use of laparoscopy in the 1990 's , many patients with heartburn and sequelae from gastroesophageal reflux disease ( gerd ) are undergoing repair of their hiatal hernias .
although there is a greater than 85% success rate , complications and failures occur following surgery ( table 1 ) .
one of ... | the increased use of laparoscopy for treatment of reflux esophagitis has been associated with a 1 - 8% complication rate .
perforation of the esophagus from bougie placement , wrap breakdown or too tight a wrap are some of the complications seen from this surgery .
an esophageal dilator system was developed to over... |
an epileptic seizure is defined as a transient symptom of abnormal excessive or synchronous firing of some or many of the brain s cells , or neurons .
the outward effect can be as dramatic as convulsions with wild thrashing movements ( tonic - clonic seizure ) or as mild as a brief loss of awareness ( absence seizure... | editor s note : epilepsy and seizures affect nearly 3 million americans of all ages .
the incidence is greater in african - americans and in socially disadvantaged populations , and about 200,000 new cases of epilepsy are diagnosed each year . despite these alarming figures , no magic pill exists to eliminate convuls... |
during a first step ( november 2009february 2010 ) , seroprevalence rates for a(h1n1)pdm09 virus were assessed in 120 breeding pigs ( > 4 years old ) from 57 farms .
blood was obtained from randomly selected pigs at the only slaughterhouse on the island , where pigs are held for <3 hours .
we screened the samples f... | during 2009 , pandemic influenza a(h1n1)pdm09 virus affected humans on runion island .
since then , the virus has sustained circulation among local swine herds , raising concerns about the potential for genetic evolution of the virus and possible retransmission back to humans of variants with increased virulence .
... |
semiconductor quantum dots are excellent fluorescent nanoprobes for biological and biomedical applications because of their unique size - dependent optical and electronic properties ( penn et al 2003 ; alivisatos
these nanoparticles ( nps ) possess unique optical properties in comparison with traditional organic dyes... | the integration of nanotechnology with biology has produced major advances in molecular diagnostics , therapeutics , and bioengineering .
recent advances have led to the development of functionalized nanoparticles ( nps ) that are covalently linked to biological molecules such as antibodies , peptides , proteins , an... |
se presentan dos casos de hepatitis viral en los cuales la terapia convencional no fue efectiva .
ambos fueron tratados posteriormente segn protocolos de uso de medicamentos homeopticos , como se describe a continuacin .
ambos pacientes registraron una remisin sostenida durante 2 aos , luego de consumir medicamento... | abstractintroduction : two cases of viral hepatitis that had failed conventional therapy are presented .
both were subsequently treated with protocols using homeopathic medicines as detailed below .
both patients sustained remissions for 2 years after taking ultradilute natural medicines after their conventional tr... |
odontoma that was previously considered as tumor of odontogenic origin is now considered as hamartomatous dental malformation formed by the overgrowth or transitory of complete dental tissue .
odontomas are usually asymptomatic and generally consist of unerupted or impacted teeth , retained deciduous teeth , swelling... | the purpose of this paper is to describe the case of surgical management of massive compound odontoma with 36 denticles in a 9-year - boy who presented with a complaint of pain and swelling in mandibular left posterior region and retained 74 .
the denticles were removed after the removal of retained 74 completely and... |
the global hcc bridge ( bridge to better outcomes in hcc ) study was the first multiregional , large - scale , longitudinal cohort study to document the hcc patient experience from diagnosis to death.the objective was to provide an improved understanding of global patterns of hcc therapy and associated outcomes across... | background & aimshepatocellular carcinoma ( hcc ) is the second most common cause of cancer deaths worldwide .
the global hcc bridge study was a multiregional , large - scale , longitudinal cohort study undertaken to improve understanding of real - life management of patients with hcc , from diagnosis to death.method... |
several multifunctional proteins are involved in both transcriptional and translational control ( wilkinson and shyu , 2001 ) . here
we focus on a family of such multifunctional proteins , the y - box protein family , in terms of its significance in cell proliferation and cancer . as different aspects of the y - box ... | y - box proteins belong to the cold shock domain family of proteins that are known to be involved in both transcriptional and translational control . here , we give a brief overview of the structure , regulation and physiological functions of the y - box proteins .
this is followed by examining the role of y - box pr... |
it is not a specific disease entity , but a gingival response associated with a variety of conditions .
these desquamative lesions represent oral manifestations of various dermatoses which include lichen planus , pemphigus vulgaris , erythema multiform , lupus erythematosus , dermatitis herpetiformis , and chronic ul... | desquamative gingival lesions are non - plaque induced inflammatory gingival lesions .
it is a clinical description and not a diagnosis .
these desquamative lesions represent oral manifestations of various dermatoses .
discoid lupus erythematosus is one of the rare dermatoses which show desquamative lesions as or... |
rehabilitation for the cerebral palsied children should be given thought a team work
including parents as a model refers to patient centered treatment regimens1,2,3 .
this idea encourages considering parent s opinions about physiotherapy and rehabilitation
for their children with cp . for this reason , health pro... | [ purpose ] the aim of this study was to examine the agreement between physiotherapists
( pts ) and mothers ( ms ) about the treatment of children with cerebral palsy ( cp ) who
received treatment in special education and rehabilitation centers . [ subjects ] ms of 130
children with cp ( 75 boys , 55 girls ) and ... |
intoxication due to carbon monoxide ( co ) is one of the most common types of poisoning , and one of the most important toxicological global causes of morbidity and mortality ( 1 ) .
a weak association between carboxyhemoglobin ( cohb ) level and patients clinical picture is documented ( 2 ) .
co binds rapidly to h... | backgroundintoxication due to carbon monoxide ( co ) is one of the most common types of poisoning .
cardiac effects of carboxyhemoglobin ( cohb ) range from simple arrhythmias to myocardial infarction.objectivesthe current study aimed to investigate the relationship between blood carboxyhemoglobin and high - sensitiv... |
fifteen tri - colored guinea pigs were obtained from the animal experiments laboratory of north sichuan medical college and were reared in large cages .
one eye of the guinea pigs was randomly selected and treated with 7.00d lenses .
the method of cycloplegia was induced with three drops of tropicamide , and the r... | purpose : the aim of this study is to preliminarily investigate the expression of mitochondrial fusion protein 1 ( mfn1 ) in a lens - induced animal myopia ( lim ) model and to explore the relationship between mfn1 and the visual development.materials and methods : mfn1 gene expression in guinea pigs was examined durin... |
we initiated our study by investigating the reactivity of substrates derived from geraniol under our previously reported hydroamination conditions ( table 1 ) .
a variety of leaving groups , including alkoxy , silyloxy , carbonate , phosphate , and carboxylates , provided the desired product with high levels of enant... | amines with remote stereocenters ( stereocenters that are three or more bonds away from the c
n bond ) are important structural elements in many pharmaceutical agents and natural products . however , previously reported methods to prepare these compounds in an enantioselective manner are indirect and require multiste... |
the plan of treatment of deformities of the jaws includes pre - surgical orthodontic treatment designed to eliminate dental compensations present ( i.e. , the anomalies of the teeth that have taken place ) and the preparation of the dental arches in relation to the scheduled surgery . in the field of orthodontics and s... | although the le fort i osteotomy is a safe surgical technique , many complications have been reported .
we present a case of an extended cervico - facial haematoma due to delayed bleeding from the terminal branches of the maxillary artery after orthognatic surgery .
a 23-year - old man was referred to our observati... |
this article is a summary of our experience with the treatment of a patient with an extraordinarily large deep burn ( 99.5% tbsa and 23% fourth degree burn ) by using the microskin autografting and alloskin repeated grafting method to close the deep burn wound because of scarcity of skin sources of the patient .
... | summarybackgroundtreatment of extraordinarily large deep burns remains a huge clinical challenge.case reportthis article is a summary of our experience with the treatment of a patient with an extraordinarily large deep burn ( 99.5% tbsa and 23% fourth degree burn ) by using the microskin autografting and alloskin repe... |
tanzania has experienced tremendous social changes and this has affected the health status of vulnerable populations over the last few years ( mujinja and kida 2014 ) .
rural women especially have been placed in a worse health - care position compared with urban women ( tanzania gender networking program and macro 20... | there is a known high disparity in access to perinatal care services between urban and rural areas in tanzania .
this study analysed repeated cross - sectional ( rcs ) data from tanzania to explore the relationship between antenatal care ( anc ) visits , facility - based delivery and the reasons for home births in wo... |
optical coherence tomography ( oct ) allows automated quantification of both peripapillary retinal nerve fiber layer ( rnfl ) and ganglion cell - inner plexiform layer ( gcipl ) macular thicknesses , providing information on the probability of an abnormality being present after comparison with an internal normative dat... | background and objectiveto investigate and compare the false - positive ( fp ) diagnostic classification of the bruch s membrane opening minimum rim width ( bmo - mrw ) and retinal nerve fiber layer ( rnfl ) thickness in healthy eyes with tilted optic disc.materials and methodsfifty healthy eyes of 30 participants wit... |
caffeine ( 1,3,7 trimethylxanthine ) is one of the most widely used psychoactive drug in the world and consumed in various forms like tea , coffee , and colas .
the half life of caffeine is 3 - 7 hours and its significant levels can be detected in the brain after 5 minutes of oral intake , with the peak levels reachi... | background : caffeine is a pyschostimulant present in various beverages and known to alter alertness and performance by acting on the central nervous system . its effects on central nervous system have been studied using eeg , evoked potentials , fmri , and neuropsychological tests .
the stroop task is a widely used ... |
ubiquitination of specific cellular proteins serves as a signal for protein degradation , chromatin remodeling , dna repair , vesicular transport , and changes in protein localization and/or activity depending on the number and structure of the ubiquitin modification .
protein ubiquitination is highly regulated and r... | ubiquitination plays a role in virtually every cellular signaling pathway ranging from cell cycle control to dna damage response to endocytosis and gene regulation .
the bulk of our knowledge of the ubiquitination system is centered on modification of specific substrate proteins and the enzymatic cascade of ubiquitin... |
mast cells are integrally involved in cellular based immune responses to pathogens as well as inflammatory reactions prompted by pathogens or toxins [ 1 , 2 ] and have been suggested for several years to play a part in the acute phase of multiple sclerosis ( ms ) [ 38 ] .
albeit the mechanisms by which mast cells inf... | experimental autoimmune encephalomyelitis ( eae ) is a mouse model that reproduces cardinal signs of clinical , histopathological , and immunological features found in multiple sclerosis ( ms ) .
mast cells are suggested to be involved in the main inflammatory phases occurring during eae development , possibly by sec... |
the association of drinking water hardness and cardiovascular diseases ( cvds ) has been studied since more than five decades ago .
a study in england and wales showed that cardiovascular death - rates had a favorable effect in towns with harder water and had an adverse effect in towns with softer water .
another s... | background : the aim of this study is to investigate the association of calcium and magnesium concentration of drinking water with cardiovascular disease ( cvds ) in urban and rural areas of a city in iran.methods:this case - control study was conducted in 2012 in khansar county in isfahan province , iran .
we used t... |
malignant tracheoesophageal fistula ( tef ) is a serious complication of thoracic malignant diseases and is more common in esophageal cancer than in lung cancer .
tef sometimes results in aspiration pneumonia , sepsis , and malnutrition associated with trouble in eating . without proper and prompt treatment , life ex... | a 45-year - old man complaining of cough , dyspnea , and difficulty in swallowing was referred to our hospital .
chest ct scan showed a mediastinal mass compressing the trachea .
he was diagnosed with poorly differentiated lung carcinoma by percutaneous needle biopsy .
bronchoscopy and upper gastrointestinal endo... |
bardet - biedl syndrome ( bbs ) is an autosomal recessive disorder characterized by central obesity , mental impairment , rod - cone dystrophy , polydactyly , hypogonadism in males , and renal abnormalities.1,2 the causative genes have been identified as bbs1 - 14 genes that encode proteins possibly linked to cilia fun... | bardet - biedl syndrome ( bbs ) is an autosomal recessive disorder characterized by central obesity , mental impairment , rod - cone dystrophy , polydactyly , hypogonadism in males , and renal abnormalities .
the causative genes have been identified as bbs1 - 14 . in the western countries , the prevalence of this dis... |
decades of targeted studies and recent progress in phosphoproteomics has resulted in a large body of protein phosphorylation data ( 2 ) .
determining how these phosphorylation sites change through time , for example during the cell cycle or following exposure to extracellular stimuli is now possible with techniques s... | protein kinases control cellular responses by phosphorylating specific substrates .
recent proteome - wide mapping of protein phosphorylation sites by mass spectrometry has discovered thousands of in vivo sites . systematically assigning all 518 human kinases to all these sites
is a challenging problem .
the netw... |
high - density lipoprotein ( hdl ) , known as antiatherosclerotic lipoprotein , is also involved in innate immunity .
for instance , hdl binds to lipopolysaccharides ( lps ) and lipoteichoic acid ( lta ) derived from microorganisms and neutralizes the physiological activity of these molecules [ 2 , 3 ] .
additional... | high - density lipoprotein ( hdl ) is involved in innate immunity toward various infectious diseases . concerning bacteria ,
hdl is known to bind to lipopolysaccharide ( lps ) and to neutralize its physiological activity . on the other hand
, cholesterol is known to play an important role in mycobacterial entry int... |
the promotion as an associate professor ( ap ) represents the final academic step followed only by a full professorship at german universities .
the academic degree of an associate professor is invested by faculties to persons , which have received a doctorates degree , have qualified as a professor by writing a habi... | background : first quantitative evaluation of the requirements for the promotion as associate professor ( ap ) at german medical faculties material and methods : analysis of the ap - regulations of german medical faculties according to a validated scoring system , which has been adapted to this study.results : the over... |
in the present work , the possibility of increasing the lifespan of mammalians and humans by transplantation of the genetically identical ( or similar ) stem cells with the lower number of the genomic errors to the old recipients is investigated .
the idea of this method follows directly from informational theory of ... | the method of lifespan extension that is a practical application of the informational theory of aging is proposed . in this theory , the degradation ( error accumulation ) of the genetic information in cells
is considered a main cause of aging . according to it
, our method is based on the transplantation of geneti... |
oligochaete worms , as the second largest group of the annelida , occur in a wide variety of freshwater environments . within this diverse group ,
limnodrilus hoffmeisteri claparde , 1862 ( oligochaeta : tubificinae ) , is one of the most common and abundant aquatic oligochaetes .
like all other oligochaetes , the ... | the infection by limnodrilus hoffmeisteri claparde , 1862 ( oligochaeta : tubificinae ) in humans is relatively uncommon .
the present report is to describe an incidental human infection with oligochaetes in the nasal cavity of a chinese man , a 25-year - old man residing in zhangjiakou city , hebei province , china ... |
plantarflexor muscles play a critical role in ankle stabilization , and their combined
eccentric contraction decreases the rate of tibial advancement during midstance and causes
the foot and tibia to roll off over the forefoot rocker during terminal stance1 .
limited ankle dorsiflexion range of motion
( rom ) i... | [ purpose ] this study compared the emg activities of the plantarflexor and dorsiflexor
muscles during inclined walking with and without modified mobilization with movement
( modified mwm ) using tape in women with limited ankle dorsiflexion . [ subjects ] fifteen
women with limited dorsiflexion in their feet ( 2... |
since bacteria gain access to the periodontal pocket , they can invade the epithelium , connective tissue and radicular hard tissue , such as cementum and dentin , of periodontally diseased teeth1516,18 .
these sites can serve as bacterial reservoirs from which periodontal bacteria recolonize root surfaces after peri... | this study demonstrated that a significant number of bacteria is present in the radicular dentinal tubules of periodontally diseased human teeth .
ten periodontally diseased teeth were prepared and stained by brown and brenn technique for histological examination .
bacteria were detected in all teeth .
it is sugg... |
about 30 % of people with congenital hearing loss are syndromic and the remaining 70 % are non - syndromic .
in addition , most elderly people develop age - related ( late - onset ) hearing loss [ 13 ] . in general , these hearing losses have been classified as different diseases due to distinct pathogeneses [ 1 , ... | impairments of hearing and balance are major problems in the field of occupational and environmental health .
such impairments have previously been reported to be caused by genetic and environmental factors . however , their mechanisms have not been fully clarified . on the other hand ,
the inner ear contains spira... |
multiple myeloma is a malignant b - cell disorder characterized by proliferation of atypical plasma cells in bone marrow with or without the presence of monoclonal immunoglobulin protein in serum and/or urine .
multiple myeloma has correlation with plasmacytoma , which is a mass of plasma cells found outside of bon... | background .
previously we established two cell lines ( snu_mm1393_bm and snu_mm1393_sc ) from different tissues ( bone marrow and subcutis ) of mice which were injected with single patient 's myeloma sample .
we tried to define genetic changes specific for each cell line using whole exome sequencing ( wes ) .
ma... |
during the last decades , there have been great advancements in the field of preventive medicine .
research has demonstrated that nutrition plays a crucial role in the prevention of chronic diseases .
it proposes to consider food not only vital to survive , but also a mean for mental and physical well - being , con... | background : during the last decades , there have been great advancements in the field of preventive medicine .
research has demonstrated that nutrition plays a crucial role in the prevention of chronic diseases .
the concept of functional food was first introduced in japan during the 1980s .
it proposes to consi... |
the patients have various clinical features depending on the size and deleted region on chromosome 13 .
the 13q syndrome is characterized into 3 groups : group 1 in which proximal region ( q12.2-q31 ) is involved in deletion and patients tend to appear with minor abnormalities , mild to moderate mental retardation an... | patients with 13q deletion syndrome are characterized with different phenotypical features depending on the size and location of the deleted region on chromosome 13 .
these patients fall into three groups : in group 1 , deleted region is in the proximal and does not extend into q32 ; in group 2 , deleted region invol... |
pentacyclic triterpenoids have generally been utilized as biomarkers to trace genetic sources of organic matter in sedimentary environments , petroleum exploration , or paleoenvironmental reconstructions of biome changes that document climate change [ 14 ] .
the oleananes , ursanes , fernanes , lupanes , and their de... | pentacyclic triterpenol methyl ethers ( ptmes ) , germanicol methyl ether ( miliacin ) , 3-methoxyfern-9(11)-ene ( arundoin ) , -amyrin methyl ether ( iso - sawamilletin ) , and 3-methoxytaraxer-14-ene ( sawamilletin or crusgallin ) were characterized in surface sediments of the cross - river system using gas chromatog... |
immune checkpoint inhibition with the anti - ctla-4 antibody ipilimumab or the pd-1 antibodies pembrolizumab and nivolumab has become a valuable and effective treatment in metastatic melanoma .
all substances have demonstrated significant and durable tumor responses with significant prolonged progress - free and over... | abstractipilimumab is an anti - ctla-4 antibody that is approved for the treatment of metastatic malignant melanoma .
side - effects are mostly immune - mediated and in many cases the lack of specific symptoms leads to delayed diagnosis and treatment of adverse events .
we present the case of a female patient who e... |
thyroid dysfunction results in changes in cardiac contractility , cardiac output , myocardial oxygen consumption , systemic vascular resistance , and blood pressure [ 1 , 2 ] .
the relationship between abnormal thyroid function and coronary heart disease ( chd ) has been recognized for a long time , especially in hyp... | this study investigated if free t4 and tsh concentrations or thyroid function categories were associated with prevalent chd and the severity of coronary atherosclerosis in a population undergoing coronary angiography .
this was a cross - sectional study including 1799 patients who were consecutively admitted and unde... |
i wish to point out a need for clarification concerning the methodology utilized in the study
eye tracking detects disconjugate eye movements associated with structural traumatic brain injury and concussion by samadani
et al . , 2015
.
the authors state that binocular eye movements were recorded using a single... | this correspondence points out a need for clarification concerning the methodology utilized in the study
eye tracking detects disconjugate eye movements associated with structural traumatic brain injury and concussion
, recently published in
journal of neurotrauma .
the authors of the paper state that binocular... |
complications involving the spleen have been reported with infarction , abscess , subcapsular hematoma , rupture , and hyper - reactive malarial splenomegaly ( hms ) or tropical splenomegaly syndrome .
the latter is commonly understood as an immunological reaction from the infected host and may be confused with lymph... | a 4-year - old boy from the united states had been staying in indonesia for five months when he presented with fever , severe lethargy , progressive weight loss , and abdominal distension .
he was first diagnosed with plasmodium vivax infection in indonesia and received treatment with chloroquine . however , his cond... |
a nosology of psychosis would need to be based on the knowledge of the causes and pathophysiology of these psychotic symptoms .
the history of the term will be briefly described , followed by a description of its use in the current classification systems for mental disorders and a discussion on the necessity to d... | the concept of psychosis has been shaped by traditions in the concepts of mental disorders during the last 170 years .
the term psychosis still lacks a unified definition , but denotes a clinical construct composed of several symptoms .
delusions , hallucinations , and thought disorders are the core clinical feat... |
metabolic syndrome ( ms ) is a cluster of cardiovascular risk factors such as diabetes mellitus ( dm ) , pre - diabetes , central obesity , dyslipidemia , and high blood pressure ( bp).13 it is estimated that approximately one quarter of the world s population have the syndrome and people with this condition are likely... | backgroundthe aim of this study is to evaluate the impact of coexistence of metabolic syndrome ( ms ) and type 2 diabetes mellitus ( t2 dm ) on the estimated cardiovascular risk as calculated using the united kingdom prospective diabetic study risk engine ( ukpds - re ) and also to determine the impact of the coexisten... |
the sample consisted of 51 right - handed non - demented patients between 40 and 80 years , diagnosed with ipd .
they were presenting at least three cardinal signs of the disorder ( bradykinesia , rest tremor and rigidity ) .
there were 42 males and 9 females with mean ( sd ) age of 53 years ( 9.58 ) .
their educ... | background : parkinsonism is known to be associated with clinically significant impairments on an array of cognitive deficits .
the degree of impairment is dependent not only on the course of the disease , but also on other bio - social factors .
the objective of the present study was to examine the cognitive dysfu... |
subsets of 270 participants who visited our hospital for knee pain and met the american college of rheumatology criteria for symptomatic oa of the knee19 ) from october 2005 to september 2013 were evaluated .
we limited the subsets to women for avoiding the confounding variables and bias , because there were only a f... | backgroundthe relationship between osteoarthritis ( oa ) and osteoporosis ( op ) is complicated and it may differ according to the site or stage of disease . the purpose of this cross - sectional study is to examine the relationship between the severity of radiological knee oa and the degree of op in the ipsilateral pr... |
with the increasing elderly population , dementia has become one of the most common social
problems1 .
because memory impairment is
the core symptom of dementia , the majority of early interventions aim to slow cognitive
decline . in recent years
however , studies into their use
for dementia patients have f... | [ purpose ] among the non - pharmacological interventions for dementia , spaced retrieval
training ( srt ) is a good method for rehabilitating cognition .
the purpose of this study
was to examine effects of srt with errorless learning ( el ) in the rehabilitation of
patients with dementia .
[ subjects and met... |
globally , colorectal cancer ( crc ) is the fourth most common cancer in men and the third most common cancer in women1 ) .
although most crc occurs sporadically , genetic predisposition related to its pathogenesis has been reported2 ) .
one of the most investigated genotypic subtypes of crc is the aberrancy of the... | lynch syndrome is the most common inherited colon cancer syndrome .
patients with lynch syndrome develop a range of cancers including colorectal cancer ( crc ) and carry a mutation on one of the mismatched repair ( mmr ) genes .
although crc usually occurs after the fourth decade in patients with lynch syndrome har... |
pylephlebitis is defined as septic thrombophlebitis of the portal vein or one of its tributaries , usually secondary to suppuration either in the region drained by the portal venous system or in structures contiguous to the portal vein ( e.g. , the common bile duct ) .
pylephlebitis , that previously well - character... | pylephlebitis usually occurs secondary to infection in the region drained by the portal venous system .
a most common antesecent focus of infection is diverticulitis and the most common blood isolate is e. coli ( 54% ) , followed by proteus mirabilis ( 23% ) .
overall mortality is 32% and most of the patients who h... |
prostate cancer is the most commonly diagnosed cancer in men in the united states and the second most commonly diagnosed malignancy worldwide .
although many prostate cancer patients have localized disease at the time of diagnosis , some present with evidence of metastasis . in the latter cases , androgen deprivation... | purposeto determine whether statin use delays the development of castration - resistant prostate cancer ( crpc ) in patients with metastatic prostate cancer treated with androgen deprivation therapy ( adt).materials and methodsa total of 171 patients with metastatic prostate cancer at the time of diagnosis who were tre... |
sarcoidosis is an idiopathic multisystem granulomatous disease that commonly involves the lungs , eyes , lymph nodes and skin .
the disease usually begins at around 40 years of age and nearly two - thirds of the cases are females .
sarcoidosis confined to skin is quite uncommon as reported in literature , contrary ... | it is a known fact that cutaneous sarcoidosis is a great imitator in dermatology .
we report three cases of cutaneous sarcoidosis without systemic involvement and with varied dermatologic presentation with regard to age and morphology .
lesions mimicked various common dermatologic conditions , causing great confusi... |
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