Unnamed: 0 int64 0 10.4k | id int64 0 10k | text stringlengths 166 4.02k | label stringclasses 23
values |
|---|---|---|---|
700 | 3,933 | Short-term administration of captopril and nifedipine and exercise-induced albuminuria in normotensive diabetic patients with early-stage nephropathy.
Recent studies have demonstrated that short-term angiotensin converting enzyme (ACE) inhibition with captopril can reduce urinary albumin excretion rate (UAER) after ex... | C18 |
701 | 4,939 | Pedunculated soft-tissue mass on the alveolar gingiva [clinical conference]
A case of peripheral ameloblastoma, a rare intraoral neoplasm, has been presented.
The lesion appears most commonly as a mass on the mandibular lingual gingiva of patients in their fifth and sixth decades of life.
The peripheral ameloblastom... | C18 |
702 | 484 | Effect of acarbose on carbohydrate and lipid metabolism in NIDDM patients poorly controlled by sulfonylureas.
The ability of acarbose to lower plasma glucose concentration was studied in 12 patients with non-insulin-dependent diabetes mellitus (NIDDM) who were poorly controlled by diet plus sulfonylurea drugs.
Patien... | C18 |
703 | 3,932 | Marked improvement of glucose homeostasis in diabetic ob/ob mice given oral vanadate.
The trace element vanadium exerts insulinlike effects in vitro and decreases hyperglycemia in insulin-deficient animals.
This study examined whether vanadate can improve glucose homeostasis in genetically obese hyperglycemic insulin... | C18 |
704 | 6,355 | The renal concentrating defect associated with potassium depletion is independent of prostaglandin E2.
Prostaglandin E2 (PGE2) impairs the hydrosmotic effect of vasopressin in toad bladder and mammalian kidney.
Because some studies in animals have suggested that potassium depletion enhances renal PGE2 production, the... | C18 |
705 | 3,819 | Electrolyte abnormalities in the alcoholic patient.
The acute effect of ethyl alcohol ingestion is to induce diuresis with excretion of free water and preservation of electrolytes.
This occurs as the blood alcohol concentration is increasing and is due to the suppression by alcohol of the endogenous release of ADH.
... | C18 |
706 | 6,430 | Prenatal diagnosis of fetal intracranial calcifications.
A case is presented wherein fetal intracranial calcifications as a result of intrauterine cytomegalovirus infection were visualized by computed tomography and magnetic resonance imaging at 36 weeks' gestation.
Diagnosis of in utero cytomegalovirus infection was... | C18 |
707 | 5,876 | Therapy for hypercholesterolemia.
For most patients, hypercholesterolemia can be effectively lowered with drug therapy but only after several issues have been considered.
First, drug therapy should never be considered without adequate dietary intervention.
Dietary therapy may be effective for many patients with mild... | C18 |
708 | 2,721 | Neuromuscular effects of respiratory and metabolic acid-base changes in vitro with and without nondepolarizing muscle relaxants.
The effects of metabolic (bicarbonate, [HCO3]) and respiratory (carbon dioxide, PCO2) acid-base changes on indirectly elicited twitch tension with and without nondepolarizing neuromuscular b... | C18 |
709 | 4,270 | Impaired growth hormone (GH) response to pyridostigmine in type 1 diabetic patients with exaggerated GH-releasing hormone-stimulated GH secretion.
In the present study we investigated the effects of the acetylcholinesterase inhibitor pyridostigmine (PD), which is hypothesized to decrease hypothalamic somatostatin tone... | C18 |
710 | 8,432 | Lovastatin decreases coenzyme Q levels in humans.
Lovastatin is clinically used to treat patients with hypercholesterolemia and successfully lowers cholesterol levels.
The mechanism of action of lovastatin is inhibition of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, an enzyme involved in the biosynthesis of chol... | C18 |
711 | 558 | Genetic control by I-A subregion in H-2 complex of incidence of streptozocin-induced autoimmune diabetes in mice.
An experimental autoimmune diabetes in mice characterized by delayed-onset hyperglycemia with lymphocytic infiltrations of the pancreatic islets can be induced by multiple administrations of low doses of s... | C18 |
712 | 3,812 | Insulin administration via liposomes.
Liposomes have been used in insulin therapy as a means to selectively target insulin to the liver, enhance oral absorption of insulin, and prolong insulin action.
Liposomes are an effective means of delivering insulin specifically to hepatocytes.
The usefulness of hepatically ta... | C18 |
713 | 559 | Diabetes and the myo-inositol paradox.
To test the general applicability of the hypothesis that diabetes mellitus causes increased polyol pathway activity, decreased tissue free myo-inositol, and resultant pathological changes in tissues susceptible to the ravages of diabetes, we measured glucose, sorbitol, and myo-in... | C18 |
714 | 9,601 | The effect of established and gestational diabetes on pregnancy outcome.
OBJECTIVE--To study the prevalence and type of glucose intolerance in pregnancy and the effect of different types on perinatal mortality and fetal size.
DESIGN--A prospective case-control study with data collected by patient interview and examin... | C18 |
715 | 5,507 | Electron transfer flavoprotein: ubiquinone oxidoreductase (ETF:QO) deficiency in an adult.
A 19-year-old woman with mild myopathic symptoms from age 6 and fasting intolerance presented with a Reye-like syndrome and a myopathy.
Investigations disclosed a lipid storage myopathy, type II glutaric acidemia, and carnitine... | C18 |
716 | 5,243 | Parathyroid hormone-related peptide in plasma of patients with hypercalcemia and malignant lesions
We developed and validated a radioimmunoassay for circulating human parathyroid hormone-related peptide (PTHrP), based on a commercial antiserum to the synthetic 1-34 fragment of PTHrP, 125I-Tyr degrees-PTHrP(1-34) as r... | C18 |
717 | 3,681 | Effects of lovastatin in diabetic patients treated with chlorpropamide.
Patients with non-insulin dependent diabetes mellitus (NIDDM) have a higher risk of atherosclerotic cardiovascular disease than nondiabetic subjects.
In seven patients with both hypercholesterolemia and NIDDM controlled by chlorpropamide, lovasta... | C18 |
718 | 536 | Effect of cyclosporin on generalized Shwartzman reaction in diabetic rats.
The effect of cyclosporin (CsA) on the endotoxin-induced generalized Shwartzman reaction (GSR) was studied in diabetic and nondiabetic rats.
After 4.5 wk of diabetes, CsA (20 mg/kg) or intralipid as a control substance was given intraperitonea... | C18 |
719 | 2,119 | Results of vein graft reconstruction of the lower extremity in diabetic and nondiabetic patients.
The results of 171 vein grafts of the lower extremity were evaluated.
These were placed between January 1981 and December 1987 in 150 patients, 75 diabetic and 75 nondiabetic, to determine the influence of diabetes on th... | C18 |
720 | 5,782 | Organ-specific and systemic autoimmune diseases originate from defects in hematopoietic stem cells.
Transplantation of bone marrow cells from nonobese diabetic (NOD) mice, a model for type 1 diabetes mellitus, to C3H/HeN mice, which express I-E alpha molecules and have aspartic acid at residue 57 of the I-A beta chain... | C18 |
721 | 7,035 | Quantitative histologic study of the sural nerve in Lesch-Nyhan syndrome.
The sural nerve of a 31-year-old man with Lesch-Nyhan syndrome obtained at autopsy was studied histologically.
Large, myelinated nerve fibers were reduced in number and no myelinated nerve fibers larger than 5 microns were seen.
Diameter distr... | C18 |
722 | 68 | Skin manifestations in congenital deficiency of leucocyte-adherence glycoproteins (CDLG).
In congenital deficiency of leucocyte-adherence glycoproteins (CDLG) there is an immunodeficiency with impaired leucocyte function and cutaneous and extracutaneous infections occur.
In more than 30% of cases the condition has a ... | C18 |
723 | 2,497 | Pseudohypophosphatasia: aberrant localization and substrate specificity of alkaline phosphatase in cultured skin fibroblasts.
We explored the biochemical basis for the disorder pseudohypophosphatasia (PsHYPT) in one patient by examining the substrate specificity and localization of alkaline phosphatase (ALP) in cultur... | C18 |
724 | 4,770 | Central nervous system involvement in nephropathic cystinosis.
Nephropathic cystinosis, an autosomal recessive lysosomal storage disorder due to impaired cystine transport, causes damage to multiple organs that results in end-stage renal disease, hypothyroidism, and retinopathy, usually in childhood.
Dialysis and ren... | C18 |
725 | 8,648 | Indomethacin responsive hypercalcaemia associated with a renal sarcoma.
An infant presented with a non-metastatic renal spindle cell sarcoma and hypercalcaemia, which resolved after treatment with indomethacin.
There was in vivo and in vitro evidence that hypercalcaemia was mediated by circulatory prostaglandins. | C18 |
726 | 9,775 | Familial hypercatabolic hypoproteinemia. A disorder of endogenous catabolism of albumin and immunoglobulin.
The metabolism of albumin and IgG was investigated in two siblings, products of a first-cousin marriage, a female aged 34 yr and a male aged 17, who had a marked reduction in their respective serum concentration... | C18 |
727 | 7,972 | Mild hypoglycemia and impairment of brain stem and cortical evoked potentials in healthy subjects.
To evaluate the impact of mild hypoglycemia on CNS function in healthy adults, we measured brain stem auditory evoked potentials and P300 potentials (elicited by cognitive processing of auditory stimuli) during hypoglyce... | C18 |
728 | 7,795 | L-arginine augments endothelium-dependent vasodilation in cholesterol-fed rabbits.
Evidence exists that an endothelium-derived relaxing factor is nitric oxide and that L-arginine is the precursor for the synthesis of nitric oxide in vitro.
Whether exogenous L-arginine contributes to the modulation of vascular smooth ... | C18 |
729 | 6,599 | Anaesthetic problems in ex situ resection of the liver.
Ex-situ resection of the liver is a new surgical technique for treatment of liver tumours not amenable to conventional surgery.
This paper describes the cardiovascular and metabolic changes that occurred in nine consecutive such patients.
No severe haemodynamic... | C18 |
730 | 5,888 | Asian osteomalacia is determined by dietary factors when exposure to ultraviolet radiation is restricted: a risk factor model
Twenty-seven previously osteomalacic and 77 normal Asian women participated in a seven-day survey of dietary intake and daylight outdoor exposure.
Individual levels of daylight outdoor exposu... | C18 |
731 | 3,813 | Monomeric insulins and their experimental and clinical implications.
Due to the inherent pharmacokinetic properties of available insulins, normoglycemia is rarely, if ever, achieved in insulin-dependent diabetic patients without compromising their quality of life.
Subcutaneous insulin absorption is influenced by many... | C18 |
732 | 809 | Induction of renal growth and injury in the intact rat kidney by dietary deficiency of antioxidants.
We report induction of renal growth and injury in the intact rat kidney using a diet deficient in vitamin E and selenium.
This diet was imposed in 3-wk-old male weanling rats, and after 9 wk, enhancement of growth, ch... | C18 |
733 | 8,529 | The relation of serum cholesterol to risk of coronary heart disease: implications for the elderly.
Elevated cholesterol is a known risk factor for coronary heart disease (CHD) in young and middle-aged persons.
Because of the high prevalence of CHD in a growing elderly population, physicians must decide whether to dev... | C18 |
734 | 6,286 | Effects of fish-oil ingestion on cardiovascular risk factors in hyperlipidemic subjects in Israel: a randomized, double-blind crossover study.
Effects of a daily fish-oil supplement on serum lipids, apolipoproteins, and some platelet functions and hemorheologic variables were examined in 27 hyperlipidemic subjects in ... | C18 |
735 | 658 | Biliary calcium and gallstone formation.
The purpose of this paper is to present a brief overview of the current status of the field of biliary calcium and the role of calcium in the formation and maturation of gallstones.
The study of free Ca+(+) ions in bile by electrochemical potentiometric measurements using Ca+(... | C18 |
736 | 9,615 | Management of "brittle" diabetes with a preprogrammable implanted insulin pump delivering intraperitoneal insulin.
OBJECTIVE--Glycaemic control in a young woman with "brittle" diabetes.
DESIGN--Use of a preprogrammable fully implanted pump (Infusaid) to deliver insulin intraperitoneally at variable rates, giving a to... | C18 |
737 | 9,768 | Lack of 3 beta-hydroxy-delta 5-C27-steroid dehydrogenase/isomerase in fibroblasts from a child with urinary excretion of 3 beta-hydroxy-delta 5-bile acids. A new inborn error of metabolism.
Cultured fibroblasts were shown to be capable of catalyzing the conversion of 7 alpha-hydroxy-cholesterol to 7 alpha-hydroxy-4-ch... | C18 |
738 | 2,163 | Assessment of cardiac function in patients who were morbidly obese.
Cardiac function of 30 patients who were morbidly obese was studied before bariatric surgery.
Twelve patients were studied 13 +/- 4 months after surgery.
These patients had a mean age of 37.1 +/- 2.9 years and a body mass index of 50.0 +/- 1.4 kg/m2... | C18 |
739 | 471 | Effects of childbearing on glucose tolerance and NIDDM prevalence [published erratum appears in Diabetes Care 1990 Nov;13(11):1138]
The goal of this study was to estimate the effects of childbearing on subsequent glucose tolerance and non-insulin-dependent diabetes mellitus (NIDDM) prevalence.
A sample of subjects fr... | C18 |
740 | 550 | Physiological and pharmacological stimulation of pancreatic islet hormone secretion in type I diabetic pancreas allograft recipients.
Successful heterotopic and denervated pancreas allograft transplantation (PAT) often results in normoglycemia and peripheral hyperinsulinemia in insulin-dependent (type I) diabetic reci... | C18 |
741 | 2,432 | Liver pathology in morbidly obese patients with and without diabetes.
The contribution of obesity and/or diabetes to liver pathology in the morbidly obese patient is controversial.
We studied the liver biopsies of 100 consecutive patients undergoing gastric bypass surgery for morbid obesity.
Multiple morphologic par... | C18 |
742 | 4,684 | Deposits of crystalline material containing silicon in surgically excised human valves.
Ninety-seven surgically excised natural cardiac valves were examined by scanning electron microscopy and x-ray energy spectroscopy to assess the occurrence of crystalline deposits that contain the element silicon.
Valves examined ... | C18 |
743 | 5,637 | Case-control study of Cryptosporidium parvum infection in Peruvian children hospitalized for diarrhea: possible association with malnutrition and nosocomial infection.
A retrospective, hospital-based case-control study was used to investigate whether there were any clinical characteristics that could distinguish Crypt... | C18 |
744 | 7,963 | Increased susceptibility to hypoxia of prolonged action potential duration in ventricular papillary muscles from diabetic rats.
The action potential duration (APD) of ventricular muscles obtained from diabetic animals is reported to be prolonged.
We studied the effect of varied periods of diabetes on APD prolongation... | C18 |
745 | 6,360 | Does magnesium play a role in the hypokalemia of Bartter's syndrome?
A patient with Bartter's syndrome manifested hypomagnesemia in addition to hypokalemia.
Under conditions of maximal free water production, he had a fractional distal solute reabsorption of 0.65, a value consistent with a renal defect in sodium chlor... | C18 |
746 | 2,117 | Surgical management of islet cell dysmaturation syndrome in young children.
Islet cell dysmaturation syndrome (ICDS) encompasses the causes of infantile hyperinsulinemic hypoglycemia histologically described as islet cell hyperplasia, pancreatic adenomatosis and nesidioblastosis.
Eleven infants underwent 14 pancreati... | C18 |
747 | 529 | Leucine metabolism in IDDM. Role of insulin and substrate availability.
The effect of insulin on plasma amino acid concentrations and leucine metabolism was examined in 18 healthy nondiabetic young volunteers and in 7 subjects with insulin-dependent diabetes mellitus (IDDM) with the euglycemic insulin-clamp technique ... | C18 |
748 | 9,501 | A new bioprosthetic cardiac valve with reduced calcification.
A bioprosthetic cardiac valve cross-linked with a glycerol polyglycidyl ether polyepoxy compound (PC) was developed in order to reduce calcification and degeneration, which often occurs in bioprosthetic cardiac valves.
Aortic valves harvested from dogs wer... | C18 |
749 | 3,303 | Unawareness of hypoglycaemia and inadequate hypoglycaemic counterregulation: no causal relation with diabetic autonomic neuropathy
OBJECTIVE--To examine the traditional view that unawareness of hypoglycaemia and inadequate hypoglycaemic counterregulation in insulin dependent diabetes mellitus are manifestations of au... | C18 |
750 | 8,961 | Effacement of glomerular foot processes in kwashiorkor.
In a study of the pathogenesis of the oedema of kwashiorkor the ultrastructure of the kidneys from 6 children was examined shortly after they died from oedematous malnutrition.
There was a generalised effacement of the glomerular epithelial cells onto the baseme... | C18 |
751 | 3,043 | Reoperative surgery for the morbidly obese. A university experience.
Patients who undergo surgery for morbid obesity are often subjected to reoperation for a wide array of indications.
To evaluate outcome following revisional procedures, we reviewed the records of 32 such patients treated at UCLA between April 1986 a... | C18 |
752 | 8,473 | Evaluation of metastatic cardiac calcification in a model of chronic primary hyperparathyroidism.
Recent reports have fueled an interest in the prevalence and significance of metastatic calcium deposition in patients with chronic hyperparathyroidism.
Experimental data are limited by the lack of suitable in vivo anima... | C18 |
753 | 3,956 | Altered steady-state mRNA levels of basement membrane proteins in diabetic mouse kidneys and thromboxane synthase inhibition.
We examined steady-state levels of mRNA encoding type IV collagen, B1 chain of laminin, and the basement membrane heparan sulfate proteoglycan in the kidney cortex of a mouse model (KKAy) of no... | C18 |
754 | 7,708 | The macular photostress test in diabetic retinopathy and age-related macular degeneration.
We propose the macular photostress test for the evaluation of macular function in the office setting.
Eighty eyes were tested and divided into four diagnostic categories: background diabetic retinopathy, diabetic macular edema,... | C18 |
755 | 7,974 | Changes in phosphoinositide turnover, Ca2+ mobilization, and protein phosphorylation in platelets from NIDDM patients.
Enhanced platelet functions have been demonstrated in patients with non-insulin-dependent diabetes mellitus (NIDDM).
This study evaluated abnormalities in platelet signal transduction in diabetic pat... | C18 |
756 | 4,234 | Glucose and gluconeogenic substrate exchange by the forearm skeletal muscle in hyperglycemic and insulin-treated type II diabetic patients.
To determine the contribution of skeletal muscle to fasting hyperglycemia in noninsulin dependent type II diabetes (NIDDM), the forearm balance of glucose, lactate, and alanine wa... | C18 |
757 | 6,290 | Evidence for a secular change in obesity, height, and weight among Navajo Indian schoolchildren.
A survey measuring heights and weights of 1969 schoolchildren residing on the Navajo Indian Reservation was conducted in 1989.
The findings were compared with National Center for Health Statistics (NCHS) reference data an... | C18 |
758 | 6,410 | Prevalence and determinants of estrogen replacement therapy in elderly women.
To better understand which women use estrogen replacement therapy, we examined the prevalence and determinants of estrogen replacement therapy in 9704 nonblack women, age greater than or equal to 65 years, who participated in the multicenter... | C18 |
759 | 6,291 | Aggressive oral refeeding in hospitalized patients.
Malnutrition is an important clinical condition leading to increased morbidity and mortality.
This report describes an aggressive oral refeeding program of high-caloric foods, which was instituted in severely anorectic patients because of their refusal to eat meals ... | C18 |
760 | 5,572 | Argon green (514 nm) versus krypton red (647 nm) modified grid laser photocoagulation for diffuse diabetic macular edema.
Between 1984 and 1988, 225 eyes of 132 patients were entered in a prospective, randomized clinical trial to determine if any significant differences exist between treatment with argon green (514 nm... | C18 |
761 | 7,295 | On the metallothionein, glutathione and cysteine relationship in rat liver.
Stress and starvation increased liver metallothionein (MT) and decreased liver glutathione (GSH) levels.
Serum cysteine plus cystine levels were increased by stress.
The exogenous administration of GSH, while not modifying hepatic GSH conten... | C18 |
762 | 9,929 | HLA antigens and nailfold capillary microscopy studies in patients with insulin dependent and noninsulin dependent diabetes mellitus and limited joint mobility.
We investigated the HLA status of patients with diabetes associated with limited joint mobility and microvascular complications.
An increased frequency of HL... | C18 |
763 | 7,411 | Emergent signs of cancer. Recognizing them early in the office or ER.
Primary care physicians have a crucial role in recognition of potentially emergent conditions in patients with known or suspected cancer.
This task presents a significant challenge because the initial manifestations of these conditions are usually ... | C18 |
764 | 7,976 | Nephropathy in model combining genetic hypertension with experimental diabetes. Enalapril versus hydralazine and metoprolol therapy.
We compared the effects of the angiotensin-converting enzyme inhibitor enalapril and a conventional antihypertensive regimen (hydralazine and metoprolol) on kidney function, albuminuria,... | C18 |
765 | 609 | Practical nutritional advice for the elderly, Part I: Evaluation, supplements, RDAs. A geriatrics panel discussion.
By the time someone reaches old age, he or she thinks they know everything they want, or need, to know about nutrition.
Yet malnutrition and its many effects are a rising danger.
In this first of two i... | C18 |
766 | 5,176 | Is exogenous fructose metabolism truly insulin independent?
Although fructose is widely regarded as an insulin-independent fuel source, its in vivo conversion to glucose represents a theoretical limitation to its clinical usefulness in diabetics, particularly if given in large doses.
To determine whether small amount... | C18 |
767 | 9,545 | Therapeutic effects of simvastatin on hyperlipidemia in CAPD patients.
A causal link between hypercholesterolemia due to elevated plasma concentrations of LDL and VLDL remnants of CAPD patients has been established.
The effects of 24 weeks of treatment with Simvastatin, a new HMG coenzyme A-reductase inhibitor (at 20... | C18 |
768 | 467 | Effects of fish oil supplements in NIDDM subjects. Controlled study.
The aim of this study was to evaluate the effects of a fish oil preparation (MaxEPA) on hemostatic function and fasting lipid and glucose levels in non-insulin-dependent diabetic (NIDDM) subjects.
Eighty NIDDM outpatients aged 55.9 yr (mean SD 11.5 ... | C18 |
769 | 6,015 | Hypercalcemia as a clinical prodrome to lymphoma.
A 73-year-old man was admitted for evaluation of unexplained hypercalcemia and was found to have a large-cell non-Hodgkin's lymphoma with stage IV disease.
Treatment with cyclophosphamide, doxorubicin (Adriamycin), vincristine sulfate, and prednisone chemotherapy retu... | C18 |
770 | 7,971 | Role of two types of glucose transporters in enlarged adipocytes from aged obese rats.
The mechanism of insulin-resistant glucose-transport activity in enlarged aged adipocytes was examined.
Glucose-transport activity was assessed by measuring 3-O-methylglucose transport and the concentration of HepG2 erythrocyte/glu... | C18 |
771 | 7,191 | Structure and distribution of an Alu-type deletion mutation in Sandhoff disease.
Sandhoff disease is a recessively inherited lysosomal storage disease resulting from a deficiency of beta-hexosaminidase activity.
The enzyme occurs in two major forms, beta-hexosaminidase A, composed of an alpha- and beta-subunit and be... | C18 |
772 | 7,257 | Folate status assessment.
This paper is a review of established methods of folate status assessment and the primary factors that increase the risk of folate deficiency, including physiological life cycle changes.
The first stage of folate depletion can be assessed by measuring serum folate levels, which drop prior to... | C18 |
773 | 3,500 | Recent progress in understanding apolipoprotein B.
For the past 5 years, investigators from many different laboratories have contributed to a greatly increased understanding of two very important lipid-carrying proteins in plasma--apo B-100 and apo B-48.
Apo B-100, an extremely large protein composed of 4,536 amino a... | C18 |
774 | 4,188 | Total knee arthroplasty in obese patients.
We examined 182 patients (257 knees) who had had a total knee arthroplasty two to five six years earlier.
The patients were grouped into five weight classes.
Eighteen patients (twenty-seven knees) were considered moderately obese and twelve patients (twenty-seven knees), se... | C18 |
775 | 7,562 | Angiographic progression to total coronary occlusion in hyperlipidemic patients after acute myocardial infarction. POSCH Group.
The progression of coronary artery stenosis to total occlusion was assessed in 413 hyperlipidemic patients with a previous myocardial infarction.
Coronary angiograms were recorded at baselin... | C18 |
776 | 9,972 | Unresectable calcified bladder tumor: hemiacidrin irrigation as an adjunct to resection.
Radiographic calcification of urothelial malignancies is an uncommon finding.
To our knowledge, calcification of transitional cell carcinoma of the bladder preventing transurethral resection has not been reported previously.
We ... | C18 |
777 | 2,924 | Cystic tumors of the pancreas. New clinical, radiologic, and pathologic observations in 67 patients.
Within a 12-year period we treated 67 patients (49 women, 18 men; mean age, 61 years) with cystic neoplasms of the pancreas, including 18 serous cystic adenomas, 15 benign mucinous cystic neoplasms, 27 mucinous cystade... | C18 |
778 | 554 | Limited duration of remission of insulin dependency in children with recent overt type I diabetes treated with low-dose cyclosporin.
Preliminary data from our group indicated that cyclosporin A induced frequent remissions of insulin dependency in a group of 40 insulin-dependent (type I) diabetic children if given at t... | C18 |
779 | 581 | Effect of weight reduction on hepatic abnormalities in overweight patients.
The effects of weight reduction on hepatic test results and physical findings related to the liver were retrospectively evaluated in 39 overweight patients screened to exclude other factors affecting the liver.
An additional 11 overweight pat... | C18 |
780 | 3,265 | The electroretinogram in minimal diabetic retinopathy.
The pattern and diffuse flash electroretinograms were measured in 20 normal subjects and 40 diabetic patients who had either normal fundi or microaneurysms only.
The amplitudes of the pattern electroretinogram were found to be similar in both normals and diabetic... | C18 |
781 | 3,951 | Metabolic effects of hyperglycemia and hyperinsulinemia on fate of intracellular glucose in NIDDM.
Hyperglycemia in non-insulin-dependent diabetes mellitus (NIDDM) stimulates peripheral glucose uptake, which tends to compensate for impaired insulin-mediated glucose uptake.
The metabolic fate of glucose and suppressio... | C18 |
782 | 2,354 | Aortic calcified plaques and cardiovascular disease (the Framingham Study).
The relation between the presence of calcified plaques in the thoracic aorta, as detected on chest x-rays, and the development of cardiovascular disease is examined during 12 years of follow-up of the Framingham cohort (n = 5,209).
The preval... | C18 |
783 | 540 | Differences in lipoprotein subfraction composition and distribution between type I diabetic men and control subjects.
Subfractions of very-low-density and low-density lipoproteins were examined in 10 male normolipidemic type I (insulin-dependent) diabetic patients before and after improvement of metabolic control and ... | C18 |
784 | 2,474 | Diabetes mellitus and hypertension.
Hypertension and diabetes mellitus are chronic medical conditions that frequently coexist.
In the United States, it is estimated that 10 million persons suffer from diabetes mellitus, 60 million from hypertension, and 3 million from the combination of the two.
There may be a causa... | C18 |
785 | 819 | Regulation of parathyroid hormone gene expression by hypocalcemia, hypercalcemia, and vitamin D in the rat.
In vivo in the rat 1,25(OH)2D3 decreases and a low calcium increases PTH mRNA levels.
We now report the effect of 3 and 8 wk of changes in dietary vitamin D and calcium on PTH mRNA levels.
PTH mRNA levels were... | C18 |
786 | 2,451 | Hyperkalemia in the elderly.
Physiologic and pathologic events that occur in patients as they grow older may result in distal renal tubular dysfunction, as well as decreased levels of plasma renin activity and plasma aldosterone.
Such alterations result in a tendency toward hyperkalemia.
A syndrome termed hyporenine... | C18 |
787 | 9,500 | Long-term efficacy of Al3+ for prevention of bioprosthetic heart valve calcification.
AI3+ preincubation has been shown in 21 and 60 day implants to inhibit calcification of glutaraldehyde preserved bovine pericardium (GPBP) in the rat subdermal model.
This study was designed to assess the long-term anticalcification... | C18 |
788 | 7,837 | Risk factors for the development of osteoarthrosis of the knee.
The roles of physical activity (both work and leisure time), obesity, and history of significant knee injury on the development of severe osteoarthrosis (OA) of the knee were evaluated.
A case-control design compared 46 cases with a history of severe OA ... | C18 |
789 | 485 | Biguanides and sulfonylureas as combination therapy in NIDDM.
Oral combination therapy with biguanides (metformin) and sulfonylureas is discussed.
The rationale for the use of this combination is based on the different sites of action of the two kinds of drugs and the possibility for obtaining additive or potentiatin... | C18 |
790 | 3,962 | Reduced membrane fluidity in platelets from diabetic patients.
Platelets from diabetic patients are hypersensitive to agonists in vitro.
Membrane fluidity modulates cell function, and reduced membrane fluidity in cholesterol-enriched platelets is associated with platelet hypersensitivity to agonists, including thromb... | C18 |
791 | 545 | Fasting and postprandial concentrations of somatostatin-28 and somatostatin-14 in type II diabetes in men.
Recent evidence suggests that somatostatin-28 (SRIF-28), cleaved from prosomatostatin by cells of the upper intestine, acts as a nutrient-stimulated inhibitor of insulin secretion in healthy men.
A role for SRIF... | C18 |
792 | 5,279 | Cerebral malaria in children
Cerebral malaria is a rapidly progressive encephalopathy with up to 50% mortality.
A cardinal feature is the massing of red cells containing mature Plasmodium falciparum within the cerebral capillaries.
Adhesion of these parasitised red cells to endothelium, an event which may initiate ... | C18 |
793 | 3,935 | Abnormal redox status without increased lipid peroxidation in sugar cataract.
In conflict with a previous report, we find that phenolic inhibitors of lipid peroxidation (butylated hydroxytoluene [BHT] and butylated hydroxyanisole [BHA]) do not have significant inhibitory effect on galactosemic cataract formation.
Thi... | C18 |
794 | 796 | Relationship between the content of lysyl oxidase-dependent cross-links in skin collagen, nonenzymatic glycosylation, and long-term complications in type I diabetes mellitus.
Many abnormalities in collagen have been reported in insulin-dependent diabetes mellitus, some or all of which have been attributed to increased... | C18 |
795 | 6,502 | Behavioral covariates of waist-to-hip ratio in Rancho Bernardo.
We examined lifestyle and dietary habits in 685 men and 943 women (mean age 67 years) who completed an interview, examination, and food frequency questionnaire in 1984-87.
Waist-to-hip ratio increased with age and body mass index in both men and women.
... | C18 |
796 | 952 | Promoting adherence to low-fat, low-cholesterol diets: review and recommendations.
Evidence that lowering blood cholesterol levels reduces risk of coronary heart disease has prompted widespread recommendations that hyperlipidemic individuals undergo dietary therapy.
However, the extent to which people can adopt and m... | C18 |
797 | 7,970 | Polymorphisms of GLUT2 and GLUT4 genes. Use in evaluation of genetic susceptibility to NIDDM in blacks.
The liver/islet (GLUT2) and muscle/adipose tissue (GLUT4) glucose-transporter gene products, membrane proteins that facilitate glucose uptake into cells, are important molecules for normal carbohydrate metabolism.
... | C18 |
798 | 465 | Controlled study in diabetic children comparing insulin-dosage adjustment by manual and computer algorithms.
A controlled trial of a new microprocessor device for insulin-dosage adjustment was undertaken in two matched groups of a priori well-controlled diabetic children.
A prospective study design with three equal 8... | C18 |
799 | 4,264 | Association of fasting glucose levels with a delayed secretion of insulin after oral glucose in subjects with glucose intolerance.
Two hundred and nineteen second generation Japanese-American men were classified with a 75-g oral glucose tolerance test: 77 with normal glucose tolerance, 74 with impaired glucose toleran... | C18 |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.