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10.3945/jn.113.188441 | Biology_63 | In addition, men and women's varied eating habits and differences in the accuracy of food reporting may play a role in the gender gap. | The consumption of instant noodles $2 times/wk was associated with a higher prevalence of metabolic syndrome (OR: 1.68; 95% CI: 1.10, 2.55) in women but not in men (OR: 0.93; 95% CI: 0.58, 1.49; P-interaction = 0.04). | He said that can likely be attributed to biological differences (such as sex hormones and metabolism) between the sexes, as well as obesity and metabolic syndrome components. In addition, men and women's varied eating habits and differences in the accuracy of food reporting may play a role in the gender gap. Regardless... | The highest quintile for the TP was associated with decreased prevalence of elevated blood pressure (OR: 0.73; 95% CI: 0.59, 0.90) and marginally lower trends for abdominal obesity (OR: 0.76; 95% CI: 0.58, 0.98; P-trend = 0.06), but neither of the dietary patterns was associated with prevalence of metabolic syndrome. T... | [4.0, 1.0, 1.0, 4.0, 2.0] | Biology | train | 2 | news | http://www.newswise.com/articles/can-instant-noodles-lead-to-heart-disease-diabetes-and-stroke |
10.14814/phy2.13617 | Biology_64 | Melatonin levels were 88 percent lower after bright light exposure. | Melatonin levels at 10-min (P = 0.008, d = 0.70), 30-min (P = 0.006, d = 1.56), and 50-min after the start of the light exposure (P = 0.002, d = 1.86) were significantly lower than levels at the same clock times in the dim light condition (Fig. | "In this study we found that these kids were extremely sensitive to light." Melatonin levels were 88 percent lower after bright light exposure. Levels remained suppressed at least 50 minutes after the light was shut off. | Average melatonin suppression across the light exposure was 87.6 AE 10. and at the same relative clock times during the dim light condition (AUC DL ) are plotted for each subject in Figure 2 . Melatonin levels at 10-min (P = 0.008, d = 0.70), 30-min (P = 0.006, d = 1.56), and 50-min after the start of the light exposur... | [5.0, 4.0, 2.0, 5.0] | Biology | train | 4 | news | http://ct.moreover.com/?a=33480456707&p=1pl&v=1&x=hN9hUXXld--gBVhWbWCNfA |
10.1007/s10336-017-1477-0 | Biology_67 | In the end, the Liberian and icterine greenbuls turned out to share an astonishing amount of genetic similarities, much more than any other two species of greenbul. | Although the Liberian Greenbul specimen was only 33 years old, none of the above primers produced bands from that sample, consistent with significant DNA degradation. | According to the data, the most likely explanation for a lack of new Liberian greenbuls is the fact that they don't actually exist. In the end, the Liberian and icterine greenbuls turned out to share an astonishing amount of genetic similarities, much more than any other two species of greenbul. "We can't say definitiv... | Isolation of Liberian Greenbul DNA and initial PCRs were performed The most obvious feature that distinguishes it from the otherwise very similar Icterine Greenbul P. icterinus is the presence of white subterminal 'eye spots' to the wing feathers-a feature not shown by any other species of Phyllastrephus. Although the ... | [4.0, 1.0, 2.0] | Biology | train | 1 | news | http://ct.moreover.com/?a=34855042070&p=1pl&v=1&x=Aj2yuZYjg1DHHMgjyQ7rYg |
10.1016/j.mito.2018.08.001 | Biology_68 | A concussion sustained before an earlier concussion has completely resolved typically results in more severe symptoms and prolonged recovery, even if the second impact is less than the first. | If a new head injury is sustained before complete healing of an earlier concussion, the clinical severity of the second injury is amplified, and recovery is prolonged. | The molecular features of this process are universal," said Naviaux, who also directs the Mitochondrial and Metabolic Disease Center at UC San Diego. A concussion sustained before an earlier concussion has completely resolved typically results in more severe symptoms and prolonged recovery, even if the second impact is... | If healing is incomplete between injuries, more severe disease is produced. If a new head injury is sustained before complete healing of an earlier concussion, the clinical severity of the second injury is amplified, and recovery is prolonged. This occurs even when the energy of the second impact was less than the firs... | [5.0, 4.0, 5.0, 5.0, 5.0] | Biology | train | 4.8 | news | http://ct.moreover.com/?a=37052707703&p=1pl&v=1&x=sh4bblHfq4G8CThdM37YaA |
10.14814/phy2.13617 | Biology_69 | "We hope this research can help parents and clinicians make informed decisions on children's light exposure." | Findings from this study indicated that school-age children were almost twice as sensitive to the melatonin suppression effects of evening moderate bright light exposure (~580 lux) than their parents . | The study sample size was small and it used only one intensity of light, 1,000 lux, which is far greater than the intensity of a typical handheld electronic device, she notes. "We hope this research can help parents and clinicians make informed decisions on children's light exposure." The takeaway for parents today: Di... | Findings from this study mark an important step in addressing a gap in understanding the melatonin suppression response across the lifespan. Findings from this study indicated that school-age children were almost twice as sensitive to the melatonin suppression effects of evening moderate bright light exposure (~580 lux... | [2.0, 1.0, 2.0, 2.0] | Biology | train | 1.75 | news | http://healthmedicinet.com/news/preschoolers-exposed-to-nighttime-light-lack-melatonin/ |
10.1210/en.2015-2036 | Biology_7 | In mice, vitamin D signaling inhibited the expression of ID1. | These results indicate that the relationship between Id1 expression and vitamin D status/VDR signaling that we identified in our mouse studies is conserved in humans and is relevant to patients with BCa. | In mice, vitamin D signaling inhibited the expression of ID1. When these mice were deficient in serum vitamin D, due to a vitamin-D-deficient diet, ID1 expression was no longer suppressed. These results suggested that vitamin D deficiency acts in a cell autonomous manner, rather than systematically, to affect breast ca... | We found that serum 25(OH)D levels at the time of surgery were negatively associated with ID1 expression levels in the corresponding tumors (Spearman correlation coefficient r ϭ Ϫ0.579, P Ͻ .001), with every 10-ng increase in circulating 25(OH)D levels being associated with a 20% reduction in ID1 expression levels in t... | [2.0, 2.0, 4.0] | Biology | train | 2.666667 | news | http://www.oncologynurseadvisor.com/lack-of-vitamin-d-may-encourage-breast-cancer-metastasis/article/485433/ |
10.14814/phy2.13617 | Biology_70 | "We hope this research can help parents and clinicians make informed decisions on children's light exposure." | A combination of well-controlled procedures minimizing sources of error variance, a repeated-measures design, and large effect sizes led to several significant findings: (a) 1-h of bright light exposure before bedtime suppresses melatonin by~88%; (b) the effects of evening bright light exposure on melatonin levels pers... | The study sample size was small and it used only one intensity of light, 1,000 lux, which is far greater than the intensity of a typical handheld electronic device, she notes. "We hope this research can help parents and clinicians make informed decisions on children's light exposure." The takeaway for parents today: Di... | To our knowledge, this study is the first to quantify the melatonin suppression response to evening light exposure in healthy 3-to 5-year-old children. A combination of well-controlled procedures minimizing sources of error variance, a repeated-measures design, and large effect sizes led to several significant findings... | [2.0, 3.0, 1.0, 3.0, 4.0] | Biology | train | 2.6 | news | http://healthmedicinet.com/news/preschoolers-exposed-to-nighttime-light-lack-melatonin/ |
10.1126/sciadv.aat5107 | Biology_71 | The BioBits kits enable us to expose young kids, older kids, and even adults to the wonders of synthetic biology and, as a result, are poised to transform science education and society. | We anticipate that the availability of our BioBits™ kits and the data reported here will encourage teaching and broaden participation in the field of synthetic biology. | "We show that it is possible to use freeze-dried, cell-free extracts along with freeze-dried synthetic biology components to conduct innovative educational experiments in classrooms and other low-resource settings. The BioBits kits enable us to expose young kids, older kids, and even adults to the wonders of synthetic ... | Titrating the amount of DNA template results in varying levels of fluorescent protein production, which are visible to the naked eye and under a blue or black light. We anticipate that the availability of our BioBits™ kits and the data reported here will encourage teaching and broaden participation in the field of synt... | [3.0, 3.0, 5.0] | Biology | train | 3.666667 | news | http://ct.moreover.com/?a=34696777548&p=1pl&v=1&x=pxhPjHWCPi8TfA-LxM_Vbw |
10.1016/j.cell.2018.04.034 | Biology_73 | "The Prostate Cancer Foundation is proud to have funded this team, which continues to make foundational strides in identifying actionable genomic mutations in prostate cancer and using this information to identify new classes of precision treatments that can be used to improve the lives of men with prostate cancer." | CDK12 mutant cases are associated with elevated neoantigen burden ensuing from fusion-induced chimeric open reading frames and increased tumor T cell infiltration/clonal expansion. | More study is needed to understand this. "This very promising study suggests that CDK12 loss may be a biomarker for identifying prostate cancer patients who may respond to checkpoint immunotherapy," says Howard Soule, Ph.D., executive vice president and chief science officer of the Prostate Cancer Foundation. "The Pros... | CDK12 mutant cases are baseline diploid and do not exhibit DNA mutational signatures linked to defects in homologous recombination. CDK12 mutant cases are associated with elevated neoantigen burden ensuing from fusion-induced chimeric open reading frames and increased tumor T cell infiltration/clonal expansion. FTDs as... | [2.0, 1.0, 1.0, 3.0, 2.0] | Biology | train | 1.8 | news | http://ct.moreover.com/?a=34304617241&p=1pl&v=1&x=JkbWFHiGsGoeqOJxN0A0-A |
10.1016/j.cell.2013.08.004 | Biology_74 | These drugs also might have broader therapeutic value for patients with mental health issues. | As SIK1 acts to suppress the effects of light on the clock, this pathway provides a pharmacological target for the treatment of disturbed circadian rhythms, including jet lag, shift-work, and illnesses that disturb circadian timing. | The findings reveal a little bit more about how our internal clocks function. In addition, the research could pave the way for drugs that could bring bodies in tune with the solar cycle more quickly. These drugs also might have broader therapeutic value for patients with mental health issues. | Critically, we show that knockdown of Sik1 within the SCN results in extended light-induced phase shifts and an enhanced rate of re-entrainment to an advanced LD cycle. As SIK1 acts to suppress the effects of light on the clock, this pathway provides a pharmacological target for the treatment of disturbed circadian rhy... | [3.0, 1.0, 1.0, 2.0] | Biology | train | 1.75 | news | http://www.scienceworldreport.com/articles/9204/20130902/what-causes-jet-lag-internal-clock-slow-change-time.htm |
10.1186/gb-2013-14-7-r73 | Biology_76 | The vlincRNAs were shown to be present in cancerous cells as well as stem cells and normal human tissues. | Of 2,285 vlincRNAs found in cancerous or immortalized cells/tissues, 1,088 (47.7%) occurred in the non-cancerous cell lines or blood. | "Based upon this technology, we now have a greater understanding of transcriptome regulation, with potential to lead to therapeutic targets and better disease diagnostics." The vlincRNAs were shown to be present in cancerous cells as well as stem cells and normal human tissues. Researchers found that some of these vlin... | A complex normal human tissue, blood, revealed expression of 613 vlincRNAs, of which 331 (p-value 2.03 × 10 -49 ) overlap ENCODE vlincRNAs. Of 2,285 vlincRNAs found in cancerous or immortalized cells/tissues, 1,088 (47.7%) occurred in the non-cancerous cell lines or blood. While cancerous cells have highlyrearranged ge... | [5.0, 4.0, 4.0, 4.0] | Biology | train | 4.25 | news | http://www.sciencedaily.com/releases/2013/07/130731093915.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily+%28ScienceDaily%3A+Latest+Science+News%29 |
10.1016/j.cell.2013.08.004 | Biology_77 | Overall, the researchers found that the SIK1 protein delays the body clock's shifting response to time changes, and therefore causes complications for travelers and shift workers. | As SIK1 acts to suppress the effects of light on the clock, this pathway provides a pharmacological target for the treatment of disturbed circadian rhythms, including jet lag, shift-work, and illnesses that disturb circadian timing. | "The study proposes that the light-stimulated production of SIK1 in turn switches off the molecular pathway that feeds into the clock mechanism, thereby halting the shifting response of the biological clock," the researchers wrote. Overall, the researchers found that the SIK1 protein delays the body clock's shifting re... | Critically, we show that knockdown of Sik1 within the SCN results in extended light-induced phase shifts and an enhanced rate of re-entrainment to an advanced LD cycle. As SIK1 acts to suppress the effects of light on the clock, this pathway provides a pharmacological target for the treatment of disturbed circadian rhy... | [3.0, 5.0, 4.0, 4.0, 3.0] | Biology | train | 3.8 | news | http://www.medicaldaily.com/jet-lag-cure-could-lie-newly-discovered-gene-255200 |
10.1007/s10336-017-1477-0 | Biology_78 | And it's not like the purported new species was even a hybrid - analysis also excluded that probability, leaving the researchers to hypothesise that the 'Liberian' greenbul was just an icterine greenbul with a juvenile nutritional deficiency that caused changes to its plumage. | That the Liberian Greenbul was heterozyogous at none of these positions strongly suggests that it was not an Icterine 9 Spotted Greenbul hybrid. | "We can't say definitively that the Liberian greenbul is the same bird as the icterine greenbul, but we have presented enough evidence that makes any other explanation seem highly unlikely." And it's not like the purported new species was even a hybrid - analysis also excluded that probability, leaving the researchers ... | In contrast, there were 9 single-bp changes and a 2-bp indel between Icterine/Liberian Greenbul sequences and that of Spotted Greenbul. That the Liberian Greenbul was heterozyogous at none of these positions strongly suggests that it was not an Icterine 9 Spotted Greenbul hybrid. The current study has failed to find an... | [4.0, 4.0, 1.0, 4.0] | Biology | train | 4 | news | http://ct.moreover.com/?a=34855042070&p=1pl&v=1&x=Aj2yuZYjg1DHHMgjyQ7rYg |
10.1038/s41467-018-05870-6 | Biology_8 | "This allows us to explore the potential of finding a novel therapeutic approach that alters energy balance in obesity and modulates the associated diseases." | These Ago2-mediated molecular events may solve the paradox of protein biosynthesis in the obese liver, demonstrate a new mechanism in the regulation of basal metabolic activity, and provide a novel therapeutic target for metabolic diseases. | "Although this is still basic science, we propose that there may be important translational implications for our findings for chronic metabolic disorders like diabetes, fatty liver diseases, and other obesity associated illnesses," said Nakamura, senior investigator and a member of the Division of Endocrinology. "This ... | This condition can amplify activation of AMPK and its substrates ULK1, MFF, and Pgc1α, leading to improved mitochondrial capacity and quality, which in turn generates sufficient energy for protein biosynthesis. These Ago2-mediated molecular events may solve the paradox of protein biosynthesis in the obese liver, demons... | [4.0, 3.0, 4.0, 4.0] | Biology | train | 3.75 | news | http://ct.moreover.com/?a=37061323146&p=1pl&v=1&x=l5-40ws2AOkos3TN_hE55A |
10.1126/sciadv.aat5107 | Biology_80 | The BioBits kits enable us to expose young kids, older kids, and even adults to the wonders of synthetic biology and, as a result, are poised to transform science education and society. | In sum, BioBits™ Bright represents a comprehensive set of educational resources for synthetic biology akin to the "chemistry set" that brought chemistry education to the masses and inspired generations of scientists. | "We show that it is possible to use freeze-dried, cell-free extracts along with freeze-dried synthetic biology components to conduct innovative educational experiments in classrooms and other low-resource settings. The BioBits kits enable us to expose young kids, older kids, and even adults to the wonders of synthetic ... | We also plan to launch a website where students can share their data and biological program designs with other users of these kits from around the world. In sum, BioBits™ Bright represents a comprehensive set of educational resources for synthetic biology akin to the "chemistry set" that brought chemistry education to ... | [3.0, 4.0, 3.0] | Biology | train | 3.333333 | news | http://ct.moreover.com/?a=34696777548&p=1pl&v=1&x=pxhPjHWCPi8TfA-LxM_Vbw |
10.1016/j.cell.2013.08.004 | Biology_82 | Dr. Russell Foster said that we were still a long way off from a jet lag cure, but added it was a step towards developing drugs for interrupted sleep cycles. | Sik1 silenced mice showed significantly faster re-entrainment when compared to the controls in both cycles ( Figure 5C ). | When they blocked the activity of SIK1, the mice adjusted faster to changes in light cycle. Dr. Russell Foster said that we were still a long way off from a jet lag cure, but added it was a step towards developing drugs for interrupted sleep cycles. "Such drugs could potentially have broader therapeutic value for peopl... | Compared with the controls, the mice with Sik1 silenced showed significantly enhanced phase shifts (98 min compared to 50 min, p = 0.036, Figure 5B ). Sik1 silenced mice showed significantly faster re-entrainment when compared to the controls in both cycles ( Figure 5C ). To illustrate the magnitude of this effect, on ... | [1.0, 1.0, 1.0, 2.0] | Biology | train | 1.25 | news | http://www.businessinsider.com/cure-for-jet-lag-2013-8 |
10.1073/pnas.1504869112 | Biology_83 | Extrapolating their results to tropical forests as a whole, the team calculated that lianas could potentially reduce long-term storage of carbon in tropical forests by one-third or more. | Likewise, a potential liana-driven shift in tree species composition may also alter long-term biomass carbon storage if the presence of lianas leads to an increase in fast-growing trees with low wood densities, as is predicted . | The researchers found that study plots with lianas accumulated 76 percent less biomass over the experimental period due to reduced tree growth and increased tree death. Extrapolating their results to tropical forests as a whole, the team calculated that lianas could potentially reduce long-term storage of carbon in tro... | Long-term Submission PDF biomass carbon storage may be further reduced if increasing liana biomass intensifies liana-tree competition and/or increases the proportion of trees that are competing with lianas. Likewise, a potential liana-driven shift in tree species composition may also alter long-term biomass carbon stor... | [4.0, 3.0, 3.0, 4.0, 4.0] | Biology | train | 3.6 | news | http://feedproxy.google.com/~r/TechnologyOrg/~3/PUyOGba13Ho/ |
10.1111/gcb.13276 | Biology_87 | Based on a massive amount of historical data, the index can be used to compare the bleaching responses of corals throughout the world and to predict which corals may be most affected by future bleaching events. | Differential bleaching among corals was widely variable (mean taxon-BRI = 25.06 AE 18.44%, AESE). | Based on a massive amount of historical data, the index can be used to compare the bleaching responses of corals throughout the world and to predict which corals may be most affected by future bleaching events. "We can see it with our eyes, and we also clearly see the progression of climate change in our data. "Coral b... | Differential bleaching among corals was widely variable (mean taxon-BRI = 25.06 AE 18.44%, AESE). We found that both extrinsic and intrinsic factors have comparable influence within a given site and event (60% and 40% of bleaching response variance of all records explained, respectively). However, when responses of ind... | [2.0, 2.0, 3.0, 3.0] | Biology | train | 2.5 | news | http://www.futurity.org/coral-reefs-climate-change-1138362/ |
10.1016/j.neuron.2014.05.028 | Biology_88 | The Tac2 gene was turned on more strongly during fear learning in mice that were previously exposed to a model of traumatic stress. | In summary, these studies provide understanding of the role of the Tac2 gene and the CeM in fear processing and provide approaches to intervention for fear-related disorders. | Out of thousands of genes they examined, their "top gene" was Tachykinin 2 or Tac2. The Tac2 gene was turned on more strongly during fear learning in mice that were previously exposed to a model of traumatic stress. "The Tac2 gene is robustly activated after fear learning and belongs to a pathway that can be specifical... | Although other molecular pathways have previously been associated with PTSD, we believe that there will be a number of different mechanisms identified that eventually will synergistically be used to target emotional memory modulation. In summary, these studies provide understanding of the role of the Tac2 gene and the ... | [4.0, 3.0, 2.0, 4.0] | Biology | train | 3.25 | news | http://www.sciencedaily.com/releases/2014/06/140630124423.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily+%28Latest+Science+News+--+ScienceDaily%29 |
10.1186/s13059-018-1434-0 | Biology_89 | "This is the first large scale study with a solid method to detect a substantial impact of negative selection in shaping cancer genomes. | However, considering the rapid increase in sequenced cancer exomes and genomes, we expect that in the near future enough data for genes under negative selection will be available to perform this type of analysis. | "We found that negative selection plays an important role in cancer evolution, which is quite controversial because it has been historically neglected in most studies and, ultimately, challenges the current paradigm of an exclusive role of positive selection in cancer," explains Dr. Schaefer. "This is the first large s... | The lack of substitutions restricts statistical power when it comes to applying a conventional Kaplan-Meier analysis. However, considering the rapid increase in sequenced cancer exomes and genomes, we expect that in the near future enough data for genes under negative selection will be available to perform this type of... | [2.0, 4.0, 3.0, 2.0] | Biology | train | 2.75 | news | http://ct.moreover.com/?a=34527375501&p=1pl&v=1&x=1CtmjzSbC1y6cGD8LDIXPA |
10.4049/jimmunol.1800107 | Biology_90 | Additionally, CLCs were shown to promote inflammation in vivo, as evidenced by an increased tissue presence of IL-1b. | 2f) , suggesting that lysosomal damage is a likely mechanism by which CLCs can induce IL-1β secretion by macrophages. | In this study, Dr. Latz's team demonstrates that CLCs are engulfed by human macrophages in vitro, resulting in the release of the pro-inflammatory cytokine IL-1b. Additionally, CLCs were shown to promote inflammation in vivo, as evidenced by an increased tissue presence of IL-1b. Importantly, chemical inhibition and sm... | Indeed, CA-074 Me inhibition blocked CLC-induced IL-1β release in a dosedependent manner (Fig. 2f) , suggesting that lysosomal damage is a likely mechanism by which CLCs can induce IL-1β secretion by macrophages. In line with a role for the NLRP3 inflammasome in the intracellular sensing of CLCs, specific inhibition of... | [3.0, 3.0, 3.0, 3.0, 4.0] | Biology | train | 3.2 | news | http://ct.moreover.com/?a=38014682083&p=1pl&v=1&x=fA9J7idoQjbuZC8wnt8o2Q |
10.1038/ncomms4632 | Biology_91 | The team's three-part nanomotor can rapidly mix and pump biochemicals and move through liquids, which is important for future applications. | More experiments are necessary to study the applications and limitations of nanomotors in a biosetting. | The team's nanomotor is an important step toward developing miniature machines that could one day move through the body to administer insulin for diabetics when needed, or target and treat cancer cells without harming good cells. The team's three-part nanomotor can rapidly mix and pump biochemicals and move through liq... | The demonstration of nanomotors for biochemical release as shown above is still in a non-bioenvironment. More experiments are necessary to study the applications and limitations of nanomotors in a biosetting. It will also be interesting to exam the release characteristics from multiple nanomotors. | [1.0, 1.0, 2.0] | Biology | train | 1.333333 | news | http://www.sciencedaily.com/releases/2014/05/140520123441.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily+%28Latest+Science+News+--+ScienceDaily%29 |
10.1111/1365-2656.12871 | Biology_92 | "The effect of RHDV disease virus on rabbits is enhanced by previous infection with MYXV virus. | There was no evidence for any long-term temporal trend in changes in the survival rates of RHDV-susceptible versus immune adults (Supporting Information Figure S2 ). | It is no longer a case of which disease is a better control agent, because their effectiveness is intrinsically linked." "The effect of RHDV disease virus on rabbits is enhanced by previous infection with MYXV virus. Survival rates were lowest for rabbits which survived MYXV infection and then were exposed to RHDV dise... | than immune adults throughout the year, with monthly survival rates being on average 25% less than for susceptible rabbits (odds ratio of hyperprior-level estimate 0.75, CI 0.68-0.82) (Figure 2 ). There was no evidence for any long-term temporal trend in changes in the survival rates of RHDV-susceptible versus immune a... | [2.0, 2.0, 1.0, 2.0] | Biology | train | 1.75 | news | http://ct.moreover.com/?a=34506942217&p=1pl&v=1&x=OCP5j07SbNKK_Tx7JPH1Dw |
10.1098/rsos.171474 | Biology_93 | That task force "found that violent video game exposure was associated with: an increased composite aggression score; increased aggressive behavior; increased aggressive cognitions; increased aggressive affect, increased desensitization, and decreased empathy; and increased physiological arousal." | As a result, we did not split data at an inflection point value or conduct the additional regression tests required to test if the nonlinear relationship between the time participants spends playing violent video games and aggression followed a step function like those found in other large-scale media effects research ... | This contradicts the consensus hammered out by an American Psychological Association task force on violent video games in 2017. That task force "found that violent video game exposure was associated with: an increased composite aggression score; increased aggressive behavior; increased aggressive cognitions; increased ... | This was not possible because the parabolic term was not significant ( p ¼ 0.624), and as such we did not have an empirical basis to calculate the local extrema as planned. As a result, we did not split data at an inflection point value or conduct the additional regression tests required to test if the nonlinear relati... | [1.0, 3.0, 2.0, 1.0] | Biology | train | 1.75 | news | http://ct.moreover.com/?a=38538076628&p=1pl&v=1&x=7Ko5INusmGh9TtCxVKqTtA |
10.1016/j.cell.2018.04.034 | Biology_94 | "This very promising study suggests that CDK12 loss may be a biomarker for identifying prostate cancer patients who may respond to checkpoint immunotherapy," says Howard Soule, Ph.D., executive vice president and chief science officer of the Prostate Cancer Foundation. | These findings gave rise to a number of clinical trials for several classes of immunotherapeutics, which have been met with mixed results. | More study is needed to understand this. "This very promising study suggests that CDK12 loss may be a biomarker for identifying prostate cancer patients who may respond to checkpoint immunotherapy," says Howard Soule, Ph.D., executive vice president and chief science officer of the Prostate Cancer Foundation. "The Pros... | In line with this possibility, high levels of CCL21 and CCL25 may mediate dendritic cell tumor trafficking and neoantigen-specific T cell clonal expansion (Chan et al., 1999; Gosling et al., 2000; . These findings gave rise to a number of clinical trials for several classes of immunotherapeutics, which have been met wi... | [1.0, 3.0, 2.0] | Biology | train | 2 | news | http://ct.moreover.com/?a=34304617241&p=1pl&v=1&x=JkbWFHiGsGoeqOJxN0A0-A |
10.1210/en.2015-2036 | Biology_95 | The research highlights a direct link between circulating vitamin D levels and the expression of a gene called ID1, known to be associated with tumor growth and breast cancer metastasis. | These studies revealed Id1 as significantly up-regulated in both the tumors that developed in vitamin D-deficient mice and the VDR KD cells, suggesting that Id1 is repressed by VDR signaling in BCa. | The research highlights a direct link between circulating vitamin D levels and the expression of a gene called ID1, known to be associated with tumor growth and breast cancer metastasis. The finding builds upon several previous studies suggesting that low levels of vitamin D not only increase a person's risk of develop... | Our results indicate that loss of vitamin D/VDR signaling is sufficient to convert the cells from nonmetastatic to metastatic. These studies revealed Id1 as significantly up-regulated in both the tumors that developed in vitamin D-deficient mice and the VDR KD cells, suggesting that Id1 is repressed by VDR signaling in... | [2.0, 3.0, 3.0, 3.0] | Biology | train | 2.75 | news | http://www.science20.com/news_articles/vitamin_d_deficiency_contributes_to_spread_of_breast_cancer_in_mice_stanford_study_finds-167109 |
10.2337/db13-1600 | Biology_96 | "But neurons in the hindbrain continue to respond to fast onset hypoglycemia even in the absence of peripheral sensors." | For example, central glycemia may serve as a reference for integrative elements of the brain against which peripheral glycemic input is measured to establish appropriate CRRs. | "This clearly shows that the brain can't detect hypoglycemia under most physiological conditions unless it has this peripheral input," Donovan said. "But neurons in the hindbrain continue to respond to fast onset hypoglycemia even in the absence of peripheral sensors." The researchers also confirmed that the spinal cor... | Alternatively, central glucose sensors may serve a synergistic and equally important role with peripheral glucose sensors in responding to hypoglycemia. For example, central glycemia may serve as a reference for integrative elements of the brain against which peripheral glycemic input is measured to establish appropria... | [4.0, 1.0, 2.0, 1.0] | Biology | train | 1 | news | http://www.healthcanal.com/metabolic-problems/diabetes/49962-diabetes-detectives.html |
10.1210/en.2015-2036 | Biology_99 | BF: I would like to emphasize that the questions we are looking at regarding vitamin D deficiency is distinct from the question of if extra vitamin D is beneficial. | However, treatment with high-dose vitamin D likely has pharmacological effects that are distinct from the pathophysiology of vitamin D deficiency. | My own opinion is a target level of 30-50 ng/mL is reasonable. BF: I would like to emphasize that the questions we are looking at regarding vitamin D deficiency is distinct from the question of if extra vitamin D is beneficial. Our data indicate that avoiding deficiency is likely a good thing but it does not necessaril... | (Endocrinology 157: 0000 -0000, 2016) However, treatment with high-dose vitamin D likely has pharmacological effects that are distinct from the pathophysiology of vitamin D deficiency. Provocatively, low vitamin D levels are associated with worse prognostic indicators and outcomes in patients with BCa (9 -11) . | [4.0, 4.0, 4.0, 4.0] | Biology | train | 4 | news | http://www.theepochtimes.com/n3/1987536-vitamin-d-deficiency-promotes-breast-cancer-growth-in-mice/ |
10.1016/j.cub.2018.06.013 | Biology_tweet_0 | New @username paper showing that birds can learn socially to recognize heterospecific alarm calls by acoustic association with known alarm calls.
DOI:
@username @username @username @username | Our work demonstrates that wild birds can learn socially to recognize previously unfamiliar sounds as alarm calls. | New @username paper showing that birds can learn socially to recognize heterospecific alarm calls by acoustic association with known alarm calls.
DOI:
@username @username @username @username | Complementary studies of social learning in captivity would be useful in examining in detail the context in which different associations are formed. Our work demonstrates that wild birds can learn socially to recognize previously unfamiliar sounds as alarm calls. In our current experiment, learning could not be asocial... | [5.0, 5.0, 4.0, 4.0, 4.0] | Biology | train | 4.4 | tweets | 1025075966756958208 |
10.1038/s41467-018-06358-z | Biology_tweet_1 | Just published in Nature: "...In any case, the burned area is robustly projected to increase. The higher the warming level is, the larger is the increase of burned area, ranging from ~40% to ~100% across the scenarios"
| The higher the warming level is, the larger is the increase of burned area, ranging from~40% to~100% across the scenarios. | Just published in Nature: "...In any case, the burned area is robustly projected to increase. The higher the warming level is, the larger is the increase of burned area, ranging from ~40% to ~100% across the scenarios"
| In any case, the burned area is robustly projected to increase. The higher the warming level is, the larger is the increase of burned area, ranging from~40% to~100% across the scenarios. Our results indicate that significant benefits would be obtained if warming were limited to well below 2°C. | [5.0, 5.0, 5.0, 5.0, 5.0] | Biology | train | 5 | tweets | 1047144638677700608 |
10.1038/s41467-018-05870-6 | Biology_tweet_10 | Regulation of energy metabolism by Ago2 provides a novel paradigm in which RNA silencing plays an integral role in determining basal metabolic activity in #obesity associated sequelae #NASH #diabetes | This study demonstrates that hepatic Ago2-mediated RNA silencing regulates energy expenditure during the course of obesity and its inactivation protects from obesity-associated glucose intolerance and hepatic steatosis in mice. | Regulation of energy metabolism by Ago2 provides a novel paradigm in which RNA silencing plays an integral role in determining basal metabolic activity in #obesity associated sequelae #NASH #diabetes | Upon loading of Ago proteins with mature miRNAs produced by the endoribonuclease Dicer 18 , RISC represses the expression of targeted mRNA through RNA silencing . This study demonstrates that hepatic Ago2-mediated RNA silencing regulates energy expenditure during the course of obesity and its inactivation protects from... | [4.0, 4.0, 4.0] | Biology | train | 4 | tweets | 1039090256606310400 |
10.1073/pnas.1504869112 | Biology_tweet_101 | Lianas reduce tropical forest carbon accumulation and storage.. read all about it:
| Lianas, per-unit biomass, have a much stronger competitive effect on trees than do other trees (3), and our findings appear to represent the unique effect of lianas on forest carbon dynamics and not merely the effect of biomass removal. | Lianas reduce tropical forest carbon accumulation and storage.. read all about it:
| Because biomass dynamics of lianas are included in the whole-forest estimates, our findings corroborate earlier research that lianas themselves do not compensate for the loss in tree biomass that they cause . Lianas, per-unit biomass, have a much stronger competitive effect on trees than do other trees (3), and our fin... | [3.0, 5.0, 4.0, 4.0, 4.0] | Biology | train | 4 | tweets | 653902927493337088 |
10.3945/jn.113.188441 | Biology_tweet_102 | Avoid! Study reveals instant noodles consumption increases chance of heart disease, #diabetes & stroke: #diet #health | The positive association between instant noodles and metabolic syndrome seen in younger, more active, and leaner women suggests that the hazards of instant noodles might not be overcome by the beneficial health effects of increased physical activity, weight loss, and young age. | Avoid! Study reveals instant noodles consumption increases chance of heart disease, #diabetes & stroke: #diet #health | In our study, the association between instant noodles and metabolic syndrome differed significantly between genders, and there was no effect modification of this association by age, BMI, or physical activity. The positive association between instant noodles and metabolic syndrome seen in younger, more active, and leane... | [2.0, 4.0, 4.0, 4.0, 3.0] | Biology | train | 3.4 | tweets | 502704410107977728 |
10.1186/s40168-015-0071-z | Biology_tweet_103 | A reason for colic in breast fed babies? RT @username: Mom's gene affects bifidobacteria in the breastfed infant gut
| It may be that the deficit in bifidobacteria that nonsecretor-fed infants experience is due to the likelihood of acquiring a species of bifidobacteria with metabolic abilities appropriate for the type of milk being consumed. | A reason for colic in breast fed babies? RT @username: Mom's gene affects bifidobacteria in the breastfed infant gut
| Understanding the mechanism behind these differences will prove crucial to potentially compensating for this problem, perhaps through carefully chosen prebiotics and/or probiotics. It may be that the deficit in bifidobacteria that nonsecretor-fed infants experience is due to the likelihood of acquiring a species of bif... | [4.0, 2.0, 4.0, 3.0] | Biology | train | 3.25 | tweets | 587636672117911553 |
10.3945/jn.113.188441 | Biology_tweet_104 | Noodles: Instant friend or fiend? New study shows link to distinct cardiometabolic risk factors, from Korean studies. | We found that the consumption of instant noodles was associated with an increased prevalence of metabolic syndrome and marginally associated with abdominal obesity, independent of the major dietary patterns, in women. | Noodles: Instant friend or fiend? New study shows link to distinct cardiometabolic risk factors, from Korean studies. | As shown in previous reports, a high intake of refined carbohydrates such as white rice is known to increase the risk of type 2 diabetes, therefore nullifying the possible association between the MP and hyperglycemia in our study. We found that the consumption of instant noodles was associated with an increased prevale... | [5.0, 5.0, 4.0] | Biology | train | 4.666667 | tweets | 501383761108672512 |
10.1126/sciadv.aat5107 | Biology_tweet_107 | Our hands on biology education kits are out @username! A fun and special collaboration between scientists and K-12 students and teachers.
#synbio #STEMeducation #scienceoutreach @username @username
| In sum, BioBits™ Bright represents a comprehensive set of educational resources for synthetic biology akin to the "chemistry set" that brought chemistry education to the masses and inspired generations of scientists. | Our hands on biology education kits are out @username! A fun and special collaboration between scientists and K-12 students and teachers.
#synbio #STEMeducation #scienceoutreach @username @username
| We also plan to launch a website where students can share their data and biological program designs with other users of these kits from around the world. In sum, BioBits™ Bright represents a comprehensive set of educational resources for synthetic biology akin to the "chemistry set" that brought chemistry education to ... | [2.0, 5.0, 5.0, 4.0, 2.0] | Biology | train | 4 | tweets | 1024733214362009601 |
10.1098/rstb.2015.0168 | Biology_tweet_108 | Our paper in PTRS, just published:Multiscale perspectives of fire, climate and humans in WNA and the Jemez Mtns, USA | Temperature-specific palaeoclimate reconstructions relevant to the south-west do show the early decades of the 1600s had relatively cool summers during this period of infrequent widespread fires in the Jemez Mountains. | Our paper in PTRS, just published:Multiscale perspectives of fire, climate and humans in WNA and the Jemez Mtns, USA | Although the SEA results support an interpretation of human interference with interannual climate-fire associations before 1680 CE, it is possible that longer-term climate patterns could have played some role in changing fire patterns. Temperature-specific palaeoclimate reconstructions relevant to the south-west do sho... | [1.0, 3.0, 2.0] | Biology | train | 2 | tweets | 735222896734310400 |
10.1073/pnas.1220333110 | Biology_tweet_109 | Alpha, beta & gamma diversity all affect ecosystem multifunctionality | Thus, in addition to conserving important species, maintaining ecosystem multifunctionality will require diverse landscape mosaics of diverse communities. | Alpha, beta & gamma diversity all affect ecosystem multifunctionality | Higher β diversity also reduced the variability in multifunctionality. Thus, in addition to conserving important species, maintaining ecosystem multifunctionality will require diverse landscape mosaics of diverse communities. The effects of individual species (3-5) and α diversity (6) also become stronger as more funct... | [3.0, 3.0, 4.0, 3.0] | Biology | train | 3.25 | tweets | 342208126310817792 |
10.1098/rsos.171474 | Biology_tweet_11 | An #OpenScience study on 1000 British teenagers aged between 14 and 15 and their carers finds no evidence that playing violent video games leads to aggressive behaviour
cc. @username @username | Results from these confirmatory analyses provided evidence that adolescents' recent violent video game play is not a statistically or practically significant correlate of their aggressive behaviour as judged by carers. | An #OpenScience study on 1000 British teenagers aged between 14 and 15 and their carers finds no evidence that playing violent video games leads to aggressive behaviour
cc. @username @username | Keeping in mind the steps taken to ensure methodological rigour, the current results bear directly on the contentious literature surrounding games. Results from these confirmatory analyses provided evidence that adolescents' recent violent video game play is not a statistically or practically significant correlate of t... | [5.0, 4.0, 5.0, 4.0] | Biology | train | 4.5 | tweets | 1095608563895074816 |
10.1007/s10336-017-1477-0 | Biology_tweet_111 | Our new paper - Taxonomic status of Liberian Greenbul - genetics suggests plumage variant of Icterine Greenbul | We therefore believe this fragment to represent part of the true mitochondrial ND2 of Liberian Greenbul. | Our new paper - Taxonomic status of Liberian Greenbul - genetics suggests plumage variant of Icterine Greenbul | The presumed nuND2 appears to be highly conserved: the two icterinus sequences isolated were identical, 1 bp different from the leucolepis allele, with a further 2 bp distance to albigularis. We therefore believe this fragment to represent part of the true mitochondrial ND2 of Liberian Greenbul. Based on a short fragme... | [2.0, 4.0, 1.0, 2.0, 2.0] | Biology | train | 2.2 | tweets | 885409579034718208 |
10.1073/pnas.1405000111 | Biology_tweet_112 | Very interesting paper reveals surprising evolutionary history of bird migration ... | Contrary to expectations, we found that long-distance migration primarily evolved through evolutionary shifts of geographic range south for the winter out of North America, as opposed to north for the summer. | Very interesting paper reveals surprising evolutionary history of bird migration ... | These results illuminate how the evolution of seasonal migration has contributed to greater niche conservatism among tropical members of this diverse avian radiation. Contrary to expectations, we found that long-distance migration primarily evolved through evolutionary shifts of geographic range south for the winter ou... | [4.0, 3.0, 3.0] | Biology | train | 3.333333 | tweets | 514381961385615360 |
10.1038/s41467-019-08382-z | Biology_tweet_113 | Check this out! New paper from @username lab in @username! @username and co-workers have shed light on how the protein Hel2 recognises stalled ribosomes and triggers the quality control pathway. Read more at: | Western blot analyses showed that the truncated proteins were more abundant than wild-type Hel2 (~1.8-fold for Hel2 1-543 and~1.9fold for Hel2 ). | Check this out! New paper from @username lab in @username! @username and co-workers have shed light on how the protein Hel2 recognises stalled ribosomes and triggers the quality control pathway. Read more at: | 6a ). Western blot analyses showed that the truncated proteins were more abundant than wild-type Hel2 (~1.8-fold for Hel2 1-543 and~1.9fold for Hel2 ). Both truncated proteins also purified more efficiently in the CRAC procedure (~1.5-2.1-fold more efficiently for Hel2 1-543 and~2.4-8.4-fold more efficiently for Hel2 1... | [2.0, 3.0, 1.0, 2.0, 2.0] | Biology | train | 2 | tweets | 1093046579366383617 |
10.1016/j.immuni.2018.03.027 | Biology_tweet_114 | Controlling Germinal Center B cell Decisions | TFH interaction strength regulates GC re-entry vs PC differentiation | TomoKurosaki @username @username | These data support a model whereby commitment to the plasma cell begins in the GC and suggest that stability of Tfh-GC B cell contacts is key for plasma cell-prone GC cell formation. | Controlling Germinal Center B cell Decisions | TFH interaction strength regulates GC re-entry vs PC differentiation | TomoKurosaki @username @username | hi CD69 hi cells, thereby affording more stable T follicular helper (Tfh)-GC B cell contacts. These data support a model whereby commitment to the plasma cell begins in the GC and suggest that stability of Tfh-GC B cell contacts is key for plasma cell-prone GC cell formation. Higher expression of ICAM-1 and SLAM in tho... | [3.0, 3.0, 1.0, 3.0] | Biology | train | 2.5 | tweets | 986801572331053056 |
10.1126/science.aam7470 | Biology_tweet_115 | Chronic neonicotinoid exposure reduces #honeybee health near corn. Nice work @username @username @username | However, in the absence of seasonlong data, it is impossible to rule out that honey bees are also chronically exposed to sublethal levels of NNIs after planting. | Chronic neonicotinoid exposure reduces #honeybee health near corn. Nice work @username @username @username | The timing of honey bee deaths in Ontario, Québec, and Indiana, along with the presence of NNI residues in dead bees and hives in the spring (11, , suggested that NNI-contaminated dust generated during seeding was the main route of acute exposure ( . However, in the absence of seasonlong data, it is impossible to rule ... | [1.0, 3.0, 3.0, 3.0] | Biology | train | 2.5 | tweets | 880487738293833728 |
10.1111/gcb.13876 | Biology_tweet_116 | Stopping #deforestation and letting harvested forests grow could remove 120bn tons of #CO2 by 2100 @username | Accounting for these delayed emissions, the net sink for carbon (declining emissions and declining rates of forest re-growth) was greatest immediately after harvests ceased and declined as regrowing forests aged. | Stopping #deforestation and letting harvested forests grow could remove 120bn tons of #CO2 by 2100 @username | Putting the tropical and temperate zone and boreal forests together, yielded a global gross sink (2006) (2007) (2008) (2009) (2010) (2011) (2012) (2013) (2014) (2015) of 4.4 PgC/year (Table 3) . Accounting for these delayed emissions, the net sink for carbon (declining emissions and declining rates of forest re-growth)... | [4.0, 5.0, 3.0] | Biology | train | 4 | tweets | 899963498612088833 |
10.1038/s41586-018-0189-9 | Biology_tweet_117 | A bit of a change to the pathology here! @username et al have just published a massive european study in nature on 'Enviroment and host as large-scale controls of ectomycorrhizal fungi'. It's worth a look! Congratulations! | We conclude that environmental and host factors explain most of the variation in ectomycorrhizal diversity, that the environmental thresholds used as major ecosystem assessment tools need adjustment and that the importance of belowground specificity and plasticity has previously been underappreciated. | A bit of a change to the pathology here! @username et al have just published a massive european study in nature on 'Enviroment and host as large-scale controls of ectomycorrhizal fungi'. It's worth a look! Congratulations! | We quantify host specificity and reveal plasticity in functional traits involved in soil foraging across gradients. We conclude that environmental and host factors explain most of the variation in ectomycorrhizal diversity, that the environmental thresholds used as major ecosystem assessment tools need adjustment and t... | [3.0, 2.0, 2.0, 5.0] | Biology | train | 3 | tweets | 1004411550348791808 |
10.1038/s41467-018-05396-x | Biology_tweet_118 | Check out this paper discussing "Block copolymer #crystalsomes with an ultrathin shell to extend #blood circulation time" with the help of #AFM experiments!
| The ultra-long circulation time of the 7-day crystallized BCCs arises from the high crystallinity and uniform crystalline chain packing on the curved BCC shells which minimize defect formation in the crystals. | Check out this paper discussing "Block copolymer #crystalsomes with an ultrathin shell to extend #blood circulation time" with the help of #AFM experiments!
| Combining all these results, we can conclude that there is a close correlation between the BCC crystallinity and the blood circulation time, shown in Fig. The ultra-long circulation time of the 7-day crystallized BCCs arises from the high crystallinity and uniform crystalline chain packing on the curved BCC shells whic... | [3.0, 3.0, 1.0, 3.0] | Biology | train | 2.5 | tweets | 1063084209894383616 |
10.1016/j.celrep.2014.05.027 | Biology_tweet_119 | @username paper: neurons transplanted into #Parkinson’s-affected brains appear healthy after 14 years #OA Week | A general assessment of the integrity of the grafted TH-immunoreactive neurons in all patients revealed cells with a healthy appearance, including a robust cell soma and absence of signs of atrophy ( Figures 1A-1C , 1F-1H, 1K-1M, and 1P-1R). | @username paper: neurons transplanted into #Parkinson’s-affected brains appear healthy after 14 years #OA Week | Postmortem examinations demonstrated that grafted dopaminergic neurons survived for up to 14 years posttransplantation. A general assessment of the integrity of the grafted TH-immunoreactive neurons in all patients revealed cells with a healthy appearance, including a robust cell soma and absence of signs of atrophy ( ... | [1.0, 5.0, 1.0] | Biology | train | 1 | tweets | 525679687767703552 |
10.1038/s41556-018-0178-0 | Biology_tweet_12 | BAP1 mutations are seen in #leukemia, #mesothelioma, #cholangiocarcinoma, uveal #melanoma & renal cancer.
Boyi Gan from @username has shown how BAP1 suppresses tumor formation through inhibition of SLC7A11 transporter & elevated ferroptosis.
| Furthermore, we show that BAP1 inhibits tumour development partly through SLC7A11 and ferroptosis, and that cancer-associated BAP1 mutants lose their abilities to repress SLC7A11 and to promote ferroptosis. | BAP1 mutations are seen in #leukemia, #mesothelioma, #cholangiocarcinoma, uveal #melanoma & renal cancer.
Boyi Gan from @username has shown how BAP1 suppresses tumor formation through inhibition of SLC7A11 transporter & elevated ferroptosis.
| Here, integrated transcriptomic, epigenomic and cancer genomic analyses link BAP1 to metabolismrelated biological processes, and identify cystine transporter SLC7A11 as a key BAP1 target gene in human cancers. Furthermore, we show that BAP1 inhibits tumour development partly through SLC7A11 and ferroptosis, and that ca... | [3.0, 5.0, 3.0, 4.0] | Biology | train | 3.75 | tweets | 1039278544168333312 |
10.1038/s41568-018-0020-9 | Biology_tweet_120 | Why have inhibitors of heat shock proteins so far failed? Gabriela Chiosis & colleagues provide their perspective on why & suggest how we can better develop and implement drugs targeting the chaperome to treat cancer.
| Ultimately, then, classical approaches to drug discovery are inappropriate when one targets the chaperome. | Why have inhibitors of heat shock proteins so far failed? Gabriela Chiosis & colleagues provide their perspective on why & suggest how we can better develop and implement drugs targeting the chaperome to treat cancer.
| This realization has implications for the development of chaperome inhibitors and emphasizes the importance of considering factors such as the residence time, pharmacokinetics (PKs) and pharmacodynamics (PDs) to fully appreciate the distinctions between HSP90 agents 145 (Box 4). Ultimately, then, classical approaches t... | [2.0, 4.0, 3.0] | Biology | train | 3 | tweets | 999647430932156416 |
10.1038/s41467-019-08895-7 | Biology_tweet_121 | Myocardial microRNA exosome messengers talk to the bone marrow | These observations are compelling, as circulating myo-miRs are not only a bio-marker, but also a functional constituent of the intricate crosstalk between ischemic heart and the remote BM organ. | Myocardial microRNA exosome messengers talk to the bone marrow | Our work reveals that exosomes released from the ischemic heart are in fact mediating the systemic response of BM PCs to the site of injury. These observations are compelling, as circulating myo-miRs are not only a bio-marker, but also a functional constituent of the intricate crosstalk between ischemic heart and the r... | [4.0, 4.0, 5.0] | Biology | train | 4.333333 | tweets | 1100714842296586240 |
10.1038/s41467-018-07557-4 | Biology_tweet_122 | New article in Nature Communications shows that melting permafrost due to #ClimateChange is a real risk in the #Arctic and that 1 million people in the global North live in high risk areas, especially in Russia, Canada and Alaska | However, I s does not include information on permafrost thaw or other potential hazard-inducing factors and in our study, I s was based on relatively coarse-scaled GIC data. | New article in Nature Communications shows that melting permafrost due to #ClimateChange is a real risk in the #Arctic and that 1 million people in the global North live in high risk areas, especially in Russia, Canada and Alaska | The value of I a ranged from 1.0 (lowest hazard potential) to 3.0 (highest hazard potential). However, I s does not include information on permafrost thaw or other potential hazard-inducing factors and in our study, I s was based on relatively coarse-scaled GIC data. In contrast, I a considers different affecting facto... | [4.0, 3.0, 3.0, 3.0, 2.0] | Biology | train | 3 | tweets | 1073214749998047233 |
10.1111/ele.12889 | Biology_tweet_123 | Decreased forest regeneration over the last 15 years suggests forests are in a precarious position
| The proportion of dry forest sites with seedling densities exceeding recruitment thresholds was also lower after 21st-century wildfires, declining from 49% (in sites that burned prior to 2000) to 30% (in sites burned since 2000; v 2 = 14.3, P = 0.0002). | Decreased forest regeneration over the last 15 years suggests forests are in a precarious position
| 2, v 2 = 8.5, P = 0.004). The proportion of dry forest sites with seedling densities exceeding recruitment thresholds was also lower after 21st-century wildfires, declining from 49% (in sites that burned prior to 2000) to 30% (in sites burned since 2000; v 2 = 14.3, P = 0.0002). Moist forest types exhibited a similar d... | [4.0, 4.0, 1.0, 4.0] | Biology | train | 4 | tweets | 940926112766537728 |
10.1111/ecog.03303 | Biology_tweet_124 | Felids face continued threat from declining prey richness
#rewilding #megafauna #biodiversity | A significant positive correlation was recorded between the number of prey species lost and the number of large-felid species lost from a cell. | Felids face continued threat from declining prey richness
#rewilding #megafauna #biodiversity | In total, 86% of cells recorded at least one additional felid species in our present-natural counterfactual, and up to 4-5 more large-felid species in 10% of the cells. A significant positive correlation was recorded between the number of prey species lost and the number of large-felid species lost from a cell. Our res... | [5.0, 5.0, 4.0, 4.0, 5.0] | Biology | train | 4.6 | tweets | 852118059770941440 |
10.1016/j.cell.2013.09.058 | Biology_tweet_125 | A new mechanism of obesity and T2D that appears to be reversible by metformin | We identified multiple rare variants in KSR2 that disrupt signaling through the Raf-MEK-ERK pathway and impair cellular fatty acid oxidation and glucose oxidation in transfected cells; effects that can be ameliorated by the commonly prescribed antidiabetic drug, metformin. | A new mechanism of obesity and T2D that appears to be reversible by metformin | Targeted deletion of Ksr2 leads to obesity in mice, suggesting a role in energy homeostasis. We identified multiple rare variants in KSR2 that disrupt signaling through the Raf-MEK-ERK pathway and impair cellular fatty acid oxidation and glucose oxidation in transfected cells; effects that can be ameliorated by the com... | [5.0, 3.0, 2.0] | Biology | train | 4 | tweets | 394460685750398976 |
10.1038/s41467-018-05738-9 | Biology_tweet_126 | Scientist Katey Walter Anthony has a new article in Nature on carbon emissions and lake thaw: | We acknowledge that present-day emissions associated with abrupt thaw may be conservative since gross lake-area increases in some regions are higher (e.g., > 50% in Quebec 85 and > 23% in West Siberia 86 ), potentially due to hydrological changes in addition to permafrost thaw. | Scientist Katey Walter Anthony has a new article in Nature on carbon emissions and lake thaw: | This range of gross lake expansion is comparable to our observation of gross lake-area increase in northern and western Alaska (i.e., 1999-2014, 1.1-1.7% gross lake area increase upscaled to 5-7% assuming similar expansion/formation rates over the past 60 years; Supplementary Table 3, Fig. We acknowledge that present-d... | [2.0, 3.0, 2.0, 5.0, 2.0] | Biology | train | 2.8 | tweets | 1030179932117204993 |
10.1021/cb4008953 | Biology_tweet_127 | Med Chem Malaria Paper of the Day:
ACS Chem Biol
ChEMBL Score: 8.52 #medchem #antimalarial #chembl #malaria_data | This highlights the potential for devising new antimalarial therapies that exploit inherent weaknesses in a key resistance mechanism of P. falciparum. | Med Chem Malaria Paper of the Day:
ACS Chem Biol
ChEMBL Score: 8.52 #medchem #antimalarial #chembl #malaria_data | Moreover, the additional parasiticidal effect exerted by 1 and 6 in the drug-resistant parasites was attributable, at least in part, to their ability to inhibit PfCRT CQR . This highlights the potential for devising new antimalarial therapies that exploit inherent weaknesses in a key resistance mechanism of P. falcipar... | [5.0, 2.0, 1.0, 2.0, 1.0] | Biology | train | 2 | tweets | 438659714285830144 |
10.1038/s41467-018-08278-4 | Biology_tweet_128 | Proteins regenerate amputated limbs 😍 Making joints is tough - even animals that regrow limbs can rarely regrow joints. These amputations treated w/ two sequential proteins grew bone & joints 🙌 Read
#health #medicine #science #amputation #regeneration | Chondrogenic genes are not expressed by cells of the amputation wound in BSA-treated control digits ( Fig. | Proteins regenerate amputated limbs 😍 Making joints is tough - even animals that regrow limbs can rarely regrow joints. These amputations treated w/ two sequential proteins grew bone & joints 🙌 Read
#health #medicine #science #amputation #regeneration | 1l) , but not by cells of the BSA-treated digits ( Supplementary Fig. Chondrogenic genes are not expressed by cells of the amputation wound in BSA-treated control digits ( Fig. In BMP9-treated non-cavity-forming digits, we find transcripts of Col2a1, Sox9, Acan, Fmod and Ucma up-regulated at the distal end of the stump... | [1.0, 1.0, 2.0] | Biology | train | 1.333333 | tweets | 1093972240092282880 |
10.1073/pnas.1420105111 | Biology_tweet_129 | Innovative approach improves #aptamer efficacy in #cancer treatment- hybridize photo-labile oligonucleotide
@username | Our strategy may provide an approach to improving the therapeutic indices of aptamer-based medicines. | Innovative approach improves #aptamer efficacy in #cancer treatment- hybridize photo-labile oligonucleotide
@username | Furthermore, the relative distribution of the aptamer to the tumor was enhanced in relation to uptake by the liver and kidneys. Our strategy may provide an approach to improving the therapeutic indices of aptamer-based medicines. (Fig. | [4.0, 5.0, 2.0, 3.0] | Biology | train | 3.5 | tweets | 534642529950371841 |
10.1186/s40168-015-0071-z | Biology_tweet_13 | Infants whose mothers have reduced breast milk oligosaccharides develop bifidobacteria-laden microbiota later | A broader range of bifidobacterial species were positively correlated with the amounts of overall bifidobacteria within secretor-fed infants than non-secretor-fed infants, suggesting that the presence of 2′-fucosylated sugars allows a broader array of bifidobacterial species to colonize the gut environment. | Infants whose mothers have reduced breast milk oligosaccharides develop bifidobacteria-laden microbiota later | However, there was a large difference in which species of bifidobacteria thrived in each group of infants (defined as a species whose presence tended to lead to domination of the microbiota by bifidobacteria). A broader range of bifidobacterial species were positively correlated with the amounts of overall bifidobacter... | [4.0, 4.0, 4.0, 3.0, 3.0] | Biology | train | 3.6 | tweets | 589260682006138880 |
10.1038/nature12167 | Biology_tweet_131 | RT @username: first ever class F GPCR structure: human SMO receptor with antagonist | Moreover, the SMO receptor can couple to G proteins, particularly G i , which inhibits cAMP production, controlling cell migration . | RT @username: first ever class F GPCR structure: human SMO receptor with antagonist | The 7TM domains of SMO and FZD receptors are reminiscent of class A GPCRs 12 although their sequences are distinct from other GPCRs, sharing less than 10% sequence identity. Moreover, the SMO receptor can couple to G proteins, particularly G i , which inhibits cAMP production, controlling cell migration . 1 ) reveals a... | [4.0, 1.0, 3.0, 1.0] | Biology | train | 1 | tweets | 329683182381314049 |
10.1038/s41467-018-05870-6 | Biology_tweet_132 | New findings from Takahisa Nakamura, PhD: Deleting a key protein from the livers of mice helped stave off #obesity, preventing both #diabetes and #fattyliverdisease. #CincyKidsScience. Read the study: | These Ago2-mediated molecular events may solve the paradox of protein biosynthesis in the obese liver, demonstrate a new mechanism in the regulation of basal metabolic activity, and provide a novel therapeutic target for metabolic diseases. | New findings from Takahisa Nakamura, PhD: Deleting a key protein from the livers of mice helped stave off #obesity, preventing both #diabetes and #fattyliverdisease. #CincyKidsScience. Read the study: | This condition can amplify activation of AMPK and its substrates ULK1, MFF, and Pgc1α, leading to improved mitochondrial capacity and quality, which in turn generates sufficient energy for protein biosynthesis. These Ago2-mediated molecular events may solve the paradox of protein biosynthesis in the obese liver, demons... | [2.0, 4.0, 2.0, 3.0, 3.0] | Biology | train | 2.8 | tweets | 1039138905902202880 |
10.1038/s41467-018-07557-4 | Biology_tweet_133 | Our brand new research highlights the risks of #permafrost thaw on #Arctic #infrastucture I'll present the permafrost #modeling and #geohazard assessments tomorrow morning in #AGU18 at session GC31B. @username
@username
@username | Moreover, we were able to quantify and show the magnitude of infrastructure at risk across the circumpolar permafrost domain. | Our brand new research highlights the risks of #permafrost thaw on #Arctic #infrastucture I'll present the permafrost #modeling and #geohazard assessments tomorrow morning in #AGU18 at session GC31B. @username
@username
@username | Consequently, detailed hazard maps and geospatial data-based computations, such as those presented here, are of importance to enable planners and policymakers to identify both high-and low hazard areas when planning future infrastructure at urban and settlement scales 33 . Moreover, we were able to quantify and show th... | [3.0, 5.0, 2.0] | Biology | train | 4 | tweets | 1072537852179832833 |
10.1186/gb-2013-14-7-r73 | Biology_tweet_134 | So you think you know about lincRNAs? But what about vlincRNAs? includes Helicos sequencing! #transcriptome #genomics | Of 2,285 vlincRNAs found in cancerous or immortalized cells/tissues, 1,088 (47.7%) occurred in the non-cancerous cell lines or blood. | So you think you know about lincRNAs? But what about vlincRNAs? includes Helicos sequencing! #transcriptome #genomics | A complex normal human tissue, blood, revealed expression of 613 vlincRNAs, of which 331 (p-value 2.03 × 10 -49 ) overlap ENCODE vlincRNAs. Of 2,285 vlincRNAs found in cancerous or immortalized cells/tissues, 1,088 (47.7%) occurred in the non-cancerous cell lines or blood. While cancerous cells have highlyrearranged ge... | [2.0, 4.0, 2.0, 4.0] | Biology | train | 3 | tweets | 359668435149520896 |
10.1111/gcb.13276 | Biology_tweet_135 | Starting a little late on #365papers, heres number 1: Swain et al 16, Coral bleaching response index... | Differential bleaching among corals was widely variable (mean taxon-BRI = 25.06 AE 18.44%, AESE). | Starting a little late on #365papers, heres number 1: Swain et al 16, Coral bleaching response index... | Differential bleaching among corals was widely variable (mean taxon-BRI = 25.06 AE 18.44%, AESE). We found that both extrinsic and intrinsic factors have comparable influence within a given site and event (60% and 40% of bleaching response variance of all records explained, respectively). However, when responses of ind... | [1.0, 4.0, 1.0, 3.0] | Biology | train | 1 | tweets | 817132227951816705 |
10.1098/rsos.180695 | Biology_tweet_136 | researchers report people set their home thermostats in the USA in ways..."most similar in climate to the outdoor conditions of west central Kenya" (N = 37, lead author's last name is "Just"...is this a Dr Just-so story?) | This literature suggests that the many ways in which the climate people prefer for their homes might be modulated and why. | researchers report people set their home thermostats in the USA in ways..."most similar in climate to the outdoor conditions of west central Kenya" (N = 37, lead author's last name is "Just"...is this a Dr Just-so story?) | Thermal comfort can be influenced by culture , by wind speed and humidity [27 -30] and mean radiant temperature . This literature suggests that the many ways in which the climate people prefer for their homes might be modulated and why. But what these do not change is the reality that thermal comfort itself, evolved. | [4.0, 4.0, 3.0, 1.0, 2.0] | Biology | train | 2.8 | tweets | 1108704958982078464 |
10.1186/s13059-018-1434-0 | Biology_tweet_137 | Negative selection in cancer, after all...and it's also the immune system! Great work by @username @username and colleagues out in @username | We present evidence for extensive negative selection over somatic point mutations in cancer exomes. | Negative selection in cancer, after all...and it's also the immune system! Great work by @username @username and colleagues out in @username | These studies help to shed light upon the mechanisms underlying immune evasion and provide insights for improving cancer immunotherapies in the future. We present evidence for extensive negative selection over somatic point mutations in cancer exomes. We exploited a large cancer exome dataset based on 26 tumor types an... | [4.0, 5.0, 5.0, 4.0, 2.0] | Biology | train | 4 | tweets | 1002465950120251392 |
10.1073/pnas.1620079114 | Biology_tweet_138 | Erythritol is associated with gains in body weight & fat; also, it isn't just a dietary sweetener, bodies make it | However, the consistency of the erythritol results in both the central adiposity and usual glycemia comparisons lends strength to the findings, and the cluster of metabolites has biological plausibility. | Erythritol is associated with gains in body weight & fat; also, it isn't just a dietary sweetener, bodies make it | The FDR-corrected statistical tests presented herein are not as robust as tests that account for both biological and technical variation . However, the consistency of the erythritol results in both the central adiposity and usual glycemia comparisons lends strength to the findings, and the cluster of metabolites has bi... | [3.0, 4.0, 3.0] | Biology | train | 3.333333 | tweets | 861694155268993026 |
10.1038/s41598-018-21058-w | Biology_tweet_14 | Can Far-UVC light help control the spread of airborne-mediated microbial diseases? We test how well our 222-nm technology works on airborne #viruses in our latest publication found on @username (its open access!) #Flu2018 #flu | If these results are confirmed in other scenarios, it follows that the use of overhead low-level far-UVC light in public locations may represent a safe and efficient methodology for limiting the transmission and spread of airborne-mediated microbial diseases such as influenza and tuberculosis. | Can Far-UVC light help control the spread of airborne-mediated microbial diseases? We test how well our 222-nm technology works on airborne #viruses in our latest publication found on @username (its open access!) #Flu2018 #flu | However as discussed above, based on biophysical considerations and in contrast to the known human health safety issues associated with conventional germicidal 254-nm broad-spectrum UVC light, far-UVC light does not appear to be cytotoxic to exposed human cells and tissues in vitro or in vivo . If these results are con... | [4.0, 4.0, 4.0, 4.0] | Biology | train | 4 | tweets | 961986502103392256 |
10.1073/pnas.1318978111 | Biology_tweet_140 | Female fertility: What's testosterone got to do with it? The paper: | Finally, we report that low doses of exogenous androgens enhance gonadotropin-induced ovulation in mice, further demonstrating the critical role that androgens play in follicular development and fertility. | Female fertility: What's testosterone got to do with it? The paper: | Interestingly, we find that the scaffold molecule paxillin regulates both processes, making it a critical regulator of AR actions in the ovary. Finally, we report that low doses of exogenous androgens enhance gonadotropin-induced ovulation in mice, further demonstrating the critical role that androgens play in follicul... | [3.0, 4.0, 3.0, 2.0] | Biology | train | 3 | tweets | 441145516475162625 |
10.1038/s41396-018-0222-x | Biology_tweet_141 | Microbial community structure predicted by the stable marriage problem. (arXiv:1712.06042v1 [q-bio.PE])
Experimental | That is to say, given its microbial partners, there is no need for a microbe to retain metabolic pathways utilizing nutrients which it never gets to use in any of the "stable marriages". | Microbial community structure predicted by the stable marriage problem. (arXiv:1712.06042v1 [q-bio.PE])
Experimental | An intriguing possibility is that the evolutionary trajectory of each species may be shaped by its partners in the SMP. That is to say, given its microbial partners, there is no need for a microbe to retain metabolic pathways utilizing nutrients which it never gets to use in any of the "stable marriages". Over evolutio... | [3.0, 3.0, 3.0, 4.0] | Biology | train | 3.25 | tweets | 942937962928422917 |
10.1002/etc.2793 | Biology_tweet_142 | Metformin, a common antidiabetic drug, acts as endocrine disrupter in fish (Env. Tox. Chem. paywall, sorry) | Metformin was below the limit of detection in control samples and was found at 41 AE 8 mg/L in treatment samples. | Metformin, a common antidiabetic drug, acts as endocrine disrupter in fish (Env. Tox. Chem. paywall, sorry) | The link between insulin signaling and steroidogenesis indicates the potential for antidiabetic drugs including metformin to act as endocrine disruptors. Metformin was below the limit of detection in control samples and was found at 41 AE 8 mg/L in treatment samples. No differences in expression were found in the liver... | [2.0, 3.0, 2.0, 2.0] | Biology | train | 2.25 | tweets | 593297064592863233 |
10.1038/ncomms4406 | Biology_tweet_143 | BELGIUM: Fullerene-free organic solar cells reaches 8.4% efficiency through multilayer cascade structures | However, the small absorption overlap with the solar spectrum limits the photocurrent generation in fullerene acceptors. | BELGIUM: Fullerene-free organic solar cells reaches 8.4% efficiency through multilayer cascade structures | These results confirm that multilayer cascade structures are a promising alternative to conventional donor-fullerene organic solar cells. However, the small absorption overlap with the solar spectrum limits the photocurrent generation in fullerene acceptors. 17) , which is comparable to the best bilayer SubPc/C 60 cell... | [2.0, 2.0, 3.0, 3.0] | Biology | train | 2.5 | tweets | 443419835804827648 |
10.1038/s41467-018-06157-6 | Biology_tweet_145 | The paper is out! Figures that show #geographic #climatic #phylogenetic patterns of #amphibian species richness in the #US. An awesome #groupeffort thanks to USGS_ARMI and lead author @username. #Scientists spent a week @username. | While we demonstrate that amphibian communities are sensitive to changes in climate, our results suggest that changing climate is not the proximate cause for ongoing assemblage-wide declines that have been observed in North American amphibians. | The paper is out! Figures that show #geographic #climatic #phylogenetic patterns of #amphibian species richness in the #US. An awesome #groupeffort thanks to USGS_ARMI and lead author @username. #Scientists spent a week @username. | For example, we found that summer drought has the strongest impact in warm and dry regions, decreased snowfall has a smaller effect in eastern compared to western North America, and winter warming is predicted to decrease species richness for all species groups except tree frogs. While we demonstrate that amphibian com... | [3.0, 3.0, 2.0, 5.0, 3.0] | Biology | train | 3.2 | tweets | 1044950968985636864 |
10.1016/j.devcel.2014.11.012 | Biology_tweet_146 | Senescent cells accelerate wound closure via PDGF-AA secretion from Campisi&co of @username | Notably, senescent cells were present only transiently during tissue repair, in contrast to the persistent presence of senescent cells in aged or chronically damaged tissues. | Senescent cells accelerate wound closure via PDGF-AA secretion from Campisi&co of @username | In contrast to the well-documented deleterious effects of senescent cells and the SASP, the results presented here unambiguously demonstrate a positive role for senescent cells and the SASP in tissue repair. Notably, senescent cells were present only transiently during tissue repair, in contrast to the persistent prese... | [2.0, 4.0, 3.0] | Biology | train | 3 | tweets | 543089204616785920 |
10.1038/ncomms7310 | Biology_tweet_147 | Again our researchers create impact in photonics via @username . Frequency combs in a silcon nanophotonic wire. | Silicon nanophotonic wire waveguides can be engineered 17 within a nanometre precision in a standard CMOS facility. | Again our researchers create impact in photonics via @username . Frequency combs in a silcon nanophotonic wire. | This aberration increases the conversion of parasitic processes significantly 12 and makes modelling difficult. Silicon nanophotonic wire waveguides can be engineered 17 within a nanometre precision in a standard CMOS facility. Such waveguides offer many advantages for mid-infrared nonlinear optics, mostly related to t... | [3.0, 3.0, 4.0, 1.0, 3.0] | Biology | train | 2.8 | tweets | 569786392999563264 |
10.1038/s41467-019-10373-z | Biology_tweet_15 | In our latest article, just out in @username we found that <0.1% of fungi, mostly belonging to Ascomycota, dominate soils globally. We mapped their global distribution and found that contain multiple genes related to stress-tolerance & resource uptake | Whole-genome comparisons with less dominant, generalist fungi point at a significantly higher number of genes related to stress-tolerance and resource uptake in the dominant fungi, suggesting that they might be better in colonising a wide range of environments. | In our latest article, just out in @username we found that <0.1% of fungi, mostly belonging to Ascomycota, dominate soils globally. We mapped their global distribution and found that contain multiple genes related to stress-tolerance & resource uptake | Our findings indicate that 83 phylotypes (<0.1% of the retrieved fungi), mostly belonging to wind dispersed, generalist Ascomycota, dominate soils globally. Whole-genome comparisons with less dominant, generalist fungi point at a significantly higher number of genes related to stress-tolerance and resource uptake in th... | [3.0, 4.0, 4.0] | Biology | train | 3.666667 | tweets | 1134024517695758336 |
10.1210/en.2015-2036 | Biology_tweet_150 | Of mice and women. Vitamin D suppls inhibits tumour-gene Id1 in breast cancer, slows growth. Deficiency accelerates | We also discovered that, although circulating 25(OH)D has many systemic effects (1), a critical mechanism for vitamin D signaling to inhibit BCa progression is a tumor autonomous activity that suppresses Id1 expression. | Of mice and women. Vitamin D suppls inhibits tumour-gene Id1 in breast cancer, slows growth. Deficiency accelerates | Further, we discovered that attenuated vitamin D signaling due to Vdr ablation enhances tumor progression and, importantly, is sufficient to enable metastases, which are the primary cause of treatment failure and death for patients with BCa. We also discovered that, although circulating 25(OH)D has many systemic effect... | [3.0, 4.0, 3.0, 4.0] | Biology | train | 3.5 | tweets | 708025691305070593 |
10.1111/1755-0998.12987 | Biology_tweet_151 | Environmental DNA for the enumeration and management of Pacific #Salmon
Researchers show daily, and near‐daily, flow‐corrected eDNA rate closely tracks daily numbers of returning sockeye and coho spawners and outmigrating sockeye smolts
#fishsci | Because the concentration of eDNA in streamwater results from both the amount of DNA shed by organisms and the flow of water, the product of eDNA concentration and streamflow (measured in units of water volume per time) can be used to calculate absolute quantities of eDNA per unit time. | Environmental DNA for the enumeration and management of Pacific #Salmon
Researchers show daily, and near‐daily, flow‐corrected eDNA rate closely tracks daily numbers of returning sockeye and coho spawners and outmigrating sockeye smolts
#fishsci | than simply accumulating as fish enter a watershed, eDNA concentrations might spike up and down as a pulse of fish swims past a sampling point, with the size of the spike correlated with fish number and/or biomass. Because the concentration of eDNA in streamwater results from both the amount of DNA shed by organisms an... | [3.0, 2.0, 4.0, 2.0] | Biology | train | 2.75 | tweets | 1080984404086964224 |
10.1016/j.ccell.2015.05.009 | Biology_tweet_152 | Wang, Shih @username & co Inhibition of SYK sensitizes ovarian cancer to paclitaxel | We found that SYK inhibitors stabilized microtubules through dephosphorylation of microtubule and microtubule-associated proteins, a mechanism that is distinct from paclitaxel. | Wang, Shih @username & co Inhibition of SYK sensitizes ovarian cancer to paclitaxel | Importantly, inhibition of SYK sensitizes ovarian cancer cells to paclitaxel treatment via enhancing microtubule stability. We found that SYK inhibitors stabilized microtubules through dephosphorylation of microtubule and microtubule-associated proteins, a mechanism that is distinct from paclitaxel. As a result, SYK in... | [2.0, 1.0, 2.0, 3.0] | Biology | train | 2 | tweets | 611837874909126656 |
10.1038/s41467-018-07600-4 | Biology_tweet_153 | Congratulations to Junwei, my dear friends first paper was just published. They discovered that magic cluster do also appear for hard sphere systems. Even more ground breaking: is systems of thousands of Colloids. Also a highly interesting reviewer 3 /1
| This raises the fundamental question of whether some colloidal cluster sizes are thermodynamically preferred over others. | Congratulations to Junwei, my dear friends first paper was just published. They discovered that magic cluster do also appear for hard sphere systems. Even more ground breaking: is systems of thousands of Colloids. Also a highly interesting reviewer 3 /1
| While the dominant occurrence of atomic clusters with magic numbers in mass spectra 4 suggests self-adjustment in their sizes during formation by addition or removal of atoms to reach magic numbers under appropriate circumstances, the number of particles in a colloidal cluster remains fixed in confinement, which allows... | [3.0, 4.0, 2.0, 3.0, 1.0] | Biology | train | 2.6 | tweets | 1072481213540167682 |
10.1111/ele.12236 | Biology_tweet_154 | Connectance of mutualistic networks increases persistance to disturbance, but result in global community collapse: | The extent to which pollinators interact with the same plant species increases with connectance and/or nestedeness. | Connectance of mutualistic networks increases persistance to disturbance, but result in global community collapse: | Our results can be understood intuitively by considering the 'net effects' of species on each other and the way in which these effects are mediated by the topology of mutualistic networks. The extent to which pollinators interact with the same plant species increases with connectance and/or nestedeness. A high nestedne... | [2.0, 2.0, 1.0, 3.0] | Biology | train | 2 | tweets | 430638501558620161 |
10.1038/s41467-018-07273-z | Biology_tweet_155 | Our 1st paper ( showing #heatwave damage to #male #reproduction & #sperm in a #insect model; out in @username! Thanks to @username @username @username @username Matt D, Aly L, Lukasz M, Laura H & Paul T. 🌞🐞 @username @username @username. | Sons of males that had been exposed to a single heatwave in the previous generation showed a 25% reduction in mating success and subsequent offspring production, compared with controls whose fathers had not experienced heatwave conditions ( Fig. | Our 1st paper ( showing #heatwave damage to #male #reproduction & #sperm in a #insect model; out in @username! Thanks to @username @username @username @username Matt D, Aly L, Lukasz M, Laura H & Paul T. 🌞🐞 @username @username @username. | 4c, d , e, f). Sons of males that had been exposed to a single heatwave in the previous generation showed a 25% reduction in mating success and subsequent offspring production, compared with controls whose fathers had not experienced heatwave conditions ( Fig. Critically, these same transgenerational effects were also ... | [3.0, 4.0, 3.0, 4.0, 4.0] | Biology | train | 3.6 | tweets | 1062319307084980224 |
10.1016/j.cmet.2015.02.003 | Biology_tweet_16 | 'Salt on Our Skin' Cutaneous Na Storage Strengthens the Antimicrobial Barrier Function & Boosts Macrophage-driven.. | Finally, we found that increasing Na + content in the skin by a high-salt diet boosted activation of macrophages in a Nfat5-dependent manner and promoted cutaneous antimicrobial defense. | 'Salt on Our Skin' Cutaneous Na Storage Strengthens the Antimicrobial Barrier Function & Boosts Macrophage-driven.. | This high-salt response resulted in elevated type-2 nitric oxide synthase (Nos2)-dependent NO production and improved Leishmania major control. Finally, we found that increasing Na + content in the skin by a high-salt diet boosted activation of macrophages in a Nfat5-dependent manner and promoted cutaneous antimicrobia... | [4.0, 4.0, 4.0] | Biology | train | 4 | tweets | 572822414125608961 |
10.1016/j.neuron.2014.05.028 | Biology_tweet_160 | See paper by Ressler and colleagues on Tac2, NkB & Nk3 Receptor in Fear Memory Consolidation | However, this does not preclude the hypothesis that different fear paradigms might reveal a role of Tac2 in the amygdala in contextual fear conditioning. | See paper by Ressler and colleagues on Tac2, NkB & Nk3 Receptor in Fear Memory Consolidation | Interestingly, in our fear paradigm, the Tac2 gene within the amygdala is involved in auditory (CS+US paired) but not stress or contextual memories (US only). However, this does not preclude the hypothesis that different fear paradigms might reveal a role of Tac2 in the amygdala in contextual fear conditioning. Thus, w... | [3.0, 4.0, 2.0] | Biology | train | 3 | tweets | 489475682549137408 |
10.1002/ece3.3060 | Biology_tweet_161 | New paper, led by @username, on how breeding phenology affects genetic structure of 4 pond-breeding #salamanders | Similarly, observed that the fall breeding A. opacum has stronger genetic differentiation than A. maculatum among the same ponds in Massachusetts. | New paper, led by @username, on how breeding phenology affects genetic structure of 4 pond-breeding #salamanders | In Missouri, found that the fall breeding A. annulatum had higher levels of genetic differentiation than the spring breeding A. maculatum on the same landscape. Similarly, observed that the fall breeding A. opacum has stronger genetic differentiation than A. maculatum among the same ponds in Massachusetts. From an evol... | [3.0, 3.0, 3.0, 3.0, 2.0] | Biology | train | 2.8 | tweets | 867064003952095235 |
10.1016/j.cell.2018.04.038 | Biology_tweet_163 | 4.8Å structure of Telomerase bound to Telomeric DNA from the labs of Juli Feigon and Hong Zhou in @username | We tried to add detergent to the sample in order to reduce exposure of particles to hydrophobic environment; however, there were very few particles in holes of cryo-EM grids in the presence of detergent (0.025% IGEPAL CA-630), suggesting that telomerase holoenzyme has affinity for the hydrophobic air/ water interface. | 4.8Å structure of Telomerase bound to Telomeric DNA from the labs of Juli Feigon and Hong Zhou in @username | This highly purified sample showed relatively good homogeneity of particles with a uniform shape in our negative stain EM images, but very high heterogeneity in our cryo-EM images. We tried to add detergent to the sample in order to reduce exposure of particles to hydrophobic environment; however, there were very few p... | [1.0, 1.0, 2.0, 2.0, 2.0] | Biology | train | 1.6 | tweets | 1002669115335573504 |
10.1038/s41467-018-07557-4 | Biology_tweet_165 | New paper from @username about the impact of thawing permafrost on infrastructure across the entire Arctic. Congrats @username et al.! | In an engineering context, the selected threshold is conservative because infrastructure (e.g., buildings) could experience thaw settlements and failure before the thaw of near-surface permafrost. | New paper from @username about the impact of thawing permafrost on infrastructure across the entire Arctic. Congrats @username et al.! | The ensemble model provided accurate predictions of the observed ground temperatures retrospectively, indicating potential for good performance in prognostic studies 23 . In an engineering context, the selected threshold is conservative because infrastructure (e.g., buildings) could experience thaw settlements and fail... | [2.0, 3.0, 2.0, 2.0] | Biology | train | 2.25 | tweets | 1072542870219952128 |
10.1111/1365-2656.12871 | Biology_tweet_166 | Our paper on disentangling disease dynamics of #rabbit haemorrhagic disease virus and #myxoma virus in Australia now online in Journal of Animal Ecology!
with @username, @username, @username, @username | The threat of diseases to wildlife populations, and the efficiency of pathogens as biocontrol agents, can only be evaluated with an adequate understanding of how different components F I G U R E 2 Estimated average changes in monthly survival rates of rabbits in different disease states, namely (i) susceptible to rabbi... | Our paper on disentangling disease dynamics of #rabbit haemorrhagic disease virus and #myxoma virus in Australia now online in Journal of Animal Ecology!
with @username, @username, @username, @username | Capture rates in most capture sessions were <40% and varied over time (Supporting Information Figure S9 ), likely explaining why uncertainty in the estimates of individual disease states and the time-specific disease effect on rabbit survival led to large credible intervals. The threat of diseases to wildlife populatio... | [4.0, 4.0, 4.0, 3.0, 2.0] | Biology | train | 3.4 | tweets | 1016577491194933248 |
10.1038/nature12167 | Biology_tweet_168 | First ever class F GPCR structure: human SMO receptor with antagonist (via @username @username @username) | The 7TM domains of SMO and FZD receptors are reminiscent of class A GPCRs 12 although their sequences are distinct from other GPCRs, sharing less than 10% sequence identity. | First ever class F GPCR structure: human SMO receptor with antagonist (via @username @username @username) | In cilia, the activated SMO receptor induces the modification of GLI transcription factors into the active form, thereby inhibiting the processing of GLI transcription factors into a repressor form. The 7TM domains of SMO and FZD receptors are reminiscent of class A GPCRs 12 although their sequences are distinct from o... | [1.0, 2.0, 2.0, 2.0] | Biology | train | 1.75 | tweets | 330273869644578818 |
10.1126/scitranslmed.aau6246 | Biology_tweet_17 | The PSEN1 inhibitor MRK-560 can target NOTCH1-mutant T-ALL, according to preclinical research. MRK-560 decreased proliferation in T-ALL cell lines and reduced #leukemia burden and increased survival in mouse models of NOTCH1-mutant T-ALL. #leusm | MRK-560 treatment significantly reduced leukemia burden compared to vehicle-treated mice, as assessed by peripheral blood counts of human CD45 + cells and in vivo bioluminescence (P ≤ 0.01) (Fig. | The PSEN1 inhibitor MRK-560 can target NOTCH1-mutant T-ALL, according to preclinical research. MRK-560 decreased proliferation in T-ALL cell lines and reduced #leukemia burden and increased survival in mouse models of NOTCH1-mutant T-ALL. #leusm | *P ≤ 0.05, ***P ≤ 0.001. MRK-560 treatment significantly reduced leukemia burden compared to vehicle-treated mice, as assessed by peripheral blood counts of human CD45 + cells and in vivo bioluminescence (P ≤ 0.01) (Fig. The various degrees of response to MRK-560 treatment were not explained by differences in PSEN1 exp... | [5.0, 4.0, 3.0, 4.0] | Biology | train | 4 | tweets | 1133808943933861890 |
10.1098/rsos.171474 | Biology_tweet_170 | Interesting article on violent video games not linked to teen aggression. @username you might be interested in this
While games can cause frustration and anger, playing video games doesn't lead to aggression in every day life.
| The semi-partial effect relating violent gaming to aggressive behaviour was r ¼ 0.01. | Interesting article on violent video games not linked to teen aggression. @username you might be interested in this
While games can cause frustration and anger, playing video games doesn't lead to aggression in every day life.
| larger) to findings present in the existing literature , and in line with proposed minimum practical media effect sizes [72] . The semi-partial effect relating violent gaming to aggressive behaviour was r ¼ 0.01. Further, we derived a 95% coincidence interval around this point estimate that ranged from 20.08 to 0.10 us... | [4.0, 4.0, 3.0, 3.0] | Biology | train | 3.5 | tweets | 1095653544047169538 |
10.1098/rsos.180695 | Biology_tweet_171 | What can we learn about the origins of humanity from our use of air conditioning? An article in our journal, #OpenScience, maps our preferences over global climate data and discovers that humans prefer the climate of west central Kenya
| When humans adjust the climates within their homes, it is unlikely that most are consciously attempting to emulate the climatic conditions of some outdoor location in another country or continent. | What can we learn about the origins of humanity from our use of air conditioning? An article in our journal, #OpenScience, maps our preferences over global climate data and discovers that humans prefer the climate of west central Kenya
| The mean vapour pressure was 12.58 hPa for North American homes and was similar to the outdoor conditions in west central Kenya (12.96 hPa). When humans adjust the climates within their homes, it is unlikely that most are consciously attempting to emulate the climatic conditions of some outdoor location in another coun... | [2.0, 2.0, 2.0] | Biology | train | 2 | tweets | 1108684701177430016 |
10.3945/jn.113.188441 | Biology_tweet_173 | Uh oh. instant #ramen linked to #metabolic syndrome. | The consumption of instant noodles was associated with increased prevalence of metabolic syndrome in women, independent of major dietary patterns. | Uh oh. instant #ramen linked to #metabolic syndrome. | The 2 major dietary patterns were associated with distinct cardiometabolic risk factors. The consumption of instant noodles was associated with increased prevalence of metabolic syndrome in women, independent of major dietary patterns. The prevalence of overweight in the adult population increased from 26% in 1998 to 3... | [4.0, 3.0, 3.0, 4.0] | Biology | train | 3.5 | tweets | 531556799586254849 |
10.3945/jn.113.188441 | Biology_tweet_174 | Instant noodle intake and cardiometabolic risk factors - PubMed - NCBI | Further adjustment by sodium intake, estrogen use, menopause, or waist circumference also did not change the positive relation between instant noodle intake $2 times/wk and metabolic syndrome in women. | Instant noodle intake and cardiometabolic risk factors - PubMed - NCBI | Consumption of instant noodles once per week was also associated with a higher prevalence of metabolic syndrome in women (OR: 1.26; 95% CI: 1.06, 1.50) but not in men. Further adjustment by sodium intake, estrogen use, menopause, or waist circumference also did not change the positive relation between instant noodle in... | [3.0, 3.0, 1.0, 4.0] | Biology | train | 2.75 | tweets | 539508237326774273 |
10.1038/s41467-019-09113-0 | Biology_tweet_175 | How can we quantitatively compare #geophysical and #geochemical data along #volcanic arcs? New research published in @username today by Till and co-authors propose an exciting new method to assess volcanic variability along the Cascades
| Given the unlikelihood of >80-90% crystallization producing the erupted compositions in nature, we also calculate a more realistic scenario in which magmas are produced by a mixture of the two end member processes with 60% of crystallization and the remainder through crustal melting. | How can we quantitatively compare #geophysical and #geochemical data along #volcanic arcs? New research published in @username today by Till and co-authors propose an exciting new method to assess volcanic variability along the Cascades
| The volume and composition of material erupted at Newberry and Three Sisters region (latitudes 43.5-44.5°N) requires a different balance between crystallization and crustal melting, as 60% crystallization does not release enough heat to produce the remainder of magmas through crustal melting. Given the unlikelihood of ... | [2.0, 4.0, 3.0, 1.0] | Biology | train | 2.5 | tweets | 1109063943023153153 |
10.1038/s41467-019-09863-x | Biology_tweet_178 | Study finds combined #permafrost melt and #albedo feedbacks in #Arctic will contribute more than expected to #climatechange. Based on current #ParisAgreement pledges predicted warming will cost $67 trillion to global economy. #ClimateAction #geog2661
| The economic losses due to climate warming also tend to be higher in warmer poorer regions such as India and Africa 20 , which are also less likely to benefit from the economic opportunities associated with a warmer Arctic 56 . | Study finds combined #permafrost melt and #albedo feedbacks in #Arctic will contribute more than expected to #climatechange. Based on current #ParisAgreement pledges predicted warming will cost $67 trillion to global economy. #ClimateAction #geog2661
| To put this number into context, it exceeds the estimated long-term gains from economic development in the Arctic region through transit shipping routes 52 and mineral resource extraction 53 under high emissions scenarios by around 10 times, and could also dwarf pan-Arctic damages to infrastructure from thawing permafr... | [2.0, 2.0, 4.0] | Biology | train | 2.666667 | tweets | 1120639268177829888 |
10.1186/gb-2013-14-7-r73 | Biology_tweet_18 | Very long intergenic RNAs (vlincRNAs) cover 10% of our genome and are frequently regulated by endogenous retroviruses | VlincRNAs were found in all cell lines tested, including non-cancerous cell lines and tissues (Table 1) . | Very long intergenic RNAs (vlincRNAs) cover 10% of our genome and are frequently regulated by endogenous retroviruses | Overall, 341 of the original 580 tumor vlincRNAs ( Table 1) overlap ENCODE vlincRNAs identified from mostly different cell lines, using a different sequencing platform (p-value 1.54 × 10 -45 ). VlincRNAs were found in all cell lines tested, including non-cancerous cell lines and tissues (Table 1) . Embryonic stem cell ... | [2.0, 2.0, 2.0] | Biology | train | 2 | tweets | 360419829343199235 |
10.1016/j.cell.2013.08.004 | Biology_tweet_181 | Sic1 makes sick in a new time zone: pill for jet lag not far @username @username @username @username | As SIK1 acts to suppress the effects of light on the clock, this pathway provides a pharmacological target for the treatment of disturbed circadian rhythms, including jet lag, shift-work, and illnesses that disturb circadian timing. | Sic1 makes sick in a new time zone: pill for jet lag not far @username @username @username @username | Critically, we show that knockdown of Sik1 within the SCN results in extended light-induced phase shifts and an enhanced rate of re-entrainment to an advanced LD cycle. As SIK1 acts to suppress the effects of light on the clock, this pathway provides a pharmacological target for the treatment of disturbed circadian rhy... | [4.0, 2.0, 3.0, 5.0] | Biology | train | 3.5 | tweets | 376331239868751872 |
10.1016/j.cell.2016.04.014 | Biology_tweet_182 | #ILCs as #ImmuneSentinels | Human ILC-Th counterparts | Colonna & Oltz @username @username | In contrast to mice, which express Il17 in both Th17s and a subset of ILC3s, humans express these cytokines only in Th17s (Figure 1E) . | #ILCs as #ImmuneSentinels | Human ILC-Th counterparts | Colonna & Oltz @username @username | We also identified an SE in Th17 cells that spanned its signature IL17A/IL17F cytokine locus, as well as the neighboring MCM3 gene, which is expressed in all cell types ( Figure 5C ). In contrast to mice, which express Il17 in both Th17s and a subset of ILC3s, humans express these cytokines only in Th17s (Figure 1E) . ... | [2.0, 2.0, 1.0, 2.0, 2.0] | Biology | train | 1.8 | tweets | 728652449200766976 |
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