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10.1038/s41467-018-04863-9 | Biology_tweet_183 | Casaccia and colleagues characterise role of PRMT5 in regulation of developmental myelination
@username @username
| PRMT5 pharmacological inhibition, CRISPR/cas9 targeting, or genetic ablation decrease p53-dependent survival and impair differentiation without affecting proliferation. | Casaccia and colleagues characterise role of PRMT5 in regulation of developmental myelination
@username @username
| PRMT5 pharmacological inhibition, CRISPR/cas9 targeting, or genetic ablation decrease p53-dependent survival and impair differentiation without affecting proliferation. Conditional ablation of Prmt5 in progenitors results in hypomyelination, reduced survival and differentiation. Decreased histone H4R3 symmetric methyla... | [5.0, 2.0, 3.0, 2.0] | Biology | train | 2 | tweets | 1021765418653032448 |
10.1038/s41467-019-09945-w | Biology_tweet_184 | New paper in @username explores the contribution of 6 socioeconomic drivers (population, economic growth, diets, ag productivity, land-use regulation, and trade) in future land-use projections. Check it out at: @username @username | Yield increase is therefore shown to be more effective in reducing land use when combined with land-use regulation and consumption changes. | New paper in @username explores the contribution of 6 socioeconomic drivers (population, economic growth, diets, ag productivity, land-use regulation, and trade) in future land-use projections. Check it out at: @username @username | Furthermore, this study adds an analysis of interactions between factors: an increase in agricultural efficiency can reduce demand for cropland but can also trigger higher demand. Yield increase is therefore shown to be more effective in reducing land use when combined with land-use regulation and consumption changes. ... | [4.0, 2.0, 3.0, 2.0, 2.0] | Biology | train | 2.6 | tweets | 1128819746214821888 |
10.1186/1471-2164-15-599 | Biology_tweet_186 | Human adaptive evolution found using #compara and #BioMart #CitedEnsembl @username | Taken together, our results strongly indicate that positive selection in neural genes is likely to have played a significant role in the human evolution. | Human adaptive evolution found using #compara and #BioMart #CitedEnsembl @username | None of these classes achieved statistical significance, except synapse in the accelerated gene set, with five observed genes compared to one expected by chance (proportion test, p < 10 −3 ). Taken together, our results strongly indicate that positive selection in neural genes is likely to have played a significant rol... | [3.0, 4.0, 3.0, 3.0] | Biology | train | 3.25 | tweets | 492585813897916416 |
10.1038/s41467-018-04627-5 | Biology_tweet_187 | Educators are the frontline of creating permanent brain changes. Classrooms are where education and neuroscience meet. @username @username @username @username @username @username @username @username @username | Widespread changes in the white matter track learning. | Educators are the frontline of creating permanent brain changes. Classrooms are where education and neuroscience meet. @username @username @username @username @username @username @username @username @username | Motion and Reading Skill were unrelated (r(97) = 0.13, p = 0.19). Widespread changes in the white matter track learning. The AF and ILF connect distinct components of the reading circuitry and are thought to carry signals that contribute uniquely to the reading process 48 . | [1.0, 1.0, 1.0, 1.0, 1.0] | Biology | train | 1 | tweets | 1005593985451220994 |
10.1126/scitranslmed.aaa8419 | Biology_tweet_188 | An unexpected microbe (Ureaplasma species) is killing lung transplant patients see more | We performed PCR and found that residual BAL fluid and blood collected shortly before his death were positive for both M. hominis and U. parvum. | An unexpected microbe (Ureaplasma species) is killing lung transplant patients see more | This patient was shown to have systemic M. hominis infection . We performed PCR and found that residual BAL fluid and blood collected shortly before his death were positive for both M. hominis and U. parvum. On postoperative day 12, he developed mental status changes, and his ammonia concentration was 549 mM. | [4.0, 3.0, 1.0, 1.0] | Biology | train | 2 | tweets | 591218843336474624 |
10.1098/rsbl.2014.0993 | Biology_tweet_189 |
First evidence of Circa-lunar Cycle in Ephedra!! @username @username | To experimentally remove the forces of celestial gravitation is difficult but our hypothesis could be further tested by experiments on moonlight detection in plants and by continuing to make predictions followed by targeted observations . |
First evidence of Circa-lunar Cycle in Ephedra!! @username @username | The full moon is thus important for efficient pollination of E. foeminea both for pollinator navigation in the dark and for attraction to the cones. To experimentally remove the forces of celestial gravitation is difficult but our hypothesis could be further tested by experiments on moonlight detection in plants and by... | [5.0, 1.0, 3.0, 2.0] | Biology | train | 2 | tweets | 583554691902087169 |
10.1073/pnas.1515733112 | Biology_tweet_190 | Stress response modulation by mitochondria [Genetics] @username | We show that mitochondrial dysfunctions altered the hypothalamicpituitary-adrenal axis, sympathetic adrenal-medullary activation and catecholamine levels, the inflammatory cytokine IL-6, circulating metabolites, and hippocampal gene expression responses to stress. | Stress response modulation by mitochondria [Genetics] @username | This work shows that mitochondria can regulate complex whole-body physiological responses, impacting stress perception at the cellular and organismal levels. We show that mitochondrial dysfunctions altered the hypothalamicpituitary-adrenal axis, sympathetic adrenal-medullary activation and catecholamine levels, the inf... | [5.0, 5.0, 4.0] | Biology | train | 4.666667 | tweets | 671832037129641984 |
10.1073/pnas.1402074111 | Biology_tweet_191 | Epitopes on the MERS COV spike protein. Important info for monitoring virus changes. | At concentrations ≥20 μg/mL, six of seven scFvFcs neutralized MERS-CoV completely (Fig. | Epitopes on the MERS COV spike protein. Important info for monitoring virus changes. | The other three scFvFcs, 1E9, M14D3, and 1F8, neutralized the virus with IC values of 3.21, 4.3, and 6.27 μg/mL, respectively (Table S1 ). At concentrations ≥20 μg/mL, six of seven scFvFcs neutralized MERS-CoV completely (Fig. Three IgG1 Abs also were tested for live virus neutralization; 3B11 had a lower IC value than... | [4.0, 2.0, 1.0, 2.0, 2.0] | Biology | train | 2.2 | tweets | 461028054945775616 |
10.1016/j.ebiom.2017.03.046 | Biology_tweet_192 | The #epigenetic clock is a better index for biological #age than #telomere length, transcriptome or metabolome | Moreover, data also suggest that most of the biological age predictors we have discussed have little or no interaction with each other. | The #epigenetic clock is a better index for biological #age than #telomere length, transcriptome or metabolome | Additional longitudinal data are necessary to further confirm the causal nature. Moreover, data also suggest that most of the biological age predictors we have discussed have little or no interaction with each other. Thus, effects are independent of each other and may therefore be describing different parts of the agin... | [3.0, 2.0, 3.0, 3.0] | Biology | train | 2.75 | tweets | 851349900793131008 |
10.1038/s41467-018-06041-3 | Biology_tweet_193 | Staufen1 is a potential therapeutic target in spinocerebellar ataxia type 2 | The strength of protein-protein interaction did not differ for wild-type and mutant ATXN2, and we found co-localization of STAU1 with ATXN2 aggregates in individuals with SCA2 and in an SCA2 mouse model (Fig. | Staufen1 is a potential therapeutic target in spinocerebellar ataxia type 2 | Here, we show for the first time that STAU1 is a novel RNAdependent interactor for ATXN2 (Fig. The strength of protein-protein interaction did not differ for wild-type and mutant ATXN2, and we found co-localization of STAU1 with ATXN2 aggregates in individuals with SCA2 and in an SCA2 mouse model (Fig. We showed increa... | [1.0, 1.0, 5.0, 1.0] | Biology | train | 1 | tweets | 1039082223973146624 |
10.1016/j.cub.2017.12.015 | Biology_tweet_194 | Learning in mosquitoes:
| This choice is not random; most mosquitoes specialize in one or a few vertebrate host species, and some individuals in a host population are preferred over others. | Learning in mosquitoes:
| This choice is not random; most mosquitoes specialize in one or a few vertebrate host species, and some individuals in a host population are preferred over others. Here, we show that olfactory learning may contribute to Aedes aegypti mosquito biting preferences and host shifts. Using pharmacological interventions, RNAi... | [2.0, 5.0, 5.0, 3.0] | Biology | train | 3 | tweets | 960285664100143104 |
10.1038/s41598-018-28950-5 | Biology_tweet_195 | #Evaluation of in vitro neuronal platforms as surrogates #for in vivo whole brain systems
Submission open for coming issue@
| Furthermore, neuronal cultures, in contrast to brain slices cultured on MEAs, are more readily adapted to human-relevant systems by utilizing either human primary or stem-cell derived neurons. | #Evaluation of in vitro neuronal platforms as surrogates #for in vivo whole brain systems
Submission open for coming issue@
| Fully validated systems hold promise for evaluating new drugs, characterizing toxicants, and aiding in the elucidation of disease mechanisms. Furthermore, neuronal cultures, in contrast to brain slices cultured on MEAs, are more readily adapted to human-relevant systems by utilizing either human primary or stem-cell de... | [5.0, 2.0, 2.0, 4.0, 2.0] | Biology | train | 2 | tweets | 1025625636830883840 |
10.1038/nbt.2488 | Biology_tweet_196 | Community-driven global reconstruction of human metabolism, new @username paper from our very own @username et al | Recon 2 will facilitate many future biomedical studies and is freely available at http://humanmetabolism.org/. | Community-driven global reconstruction of human metabolism, new @username paper from our very own @username et al | Mapping metabolomic data and drug information onto Recon 2 demonstrates its potential for integrating and analyzing diverse data types. Recon 2 will facilitate many future biomedical studies and is freely available at http://humanmetabolism.org/. r e s o u r c e of interest to the community of researchers focused on th... | [2.0, 4.0, 1.0, 1.0, 3.0] | Biology | train | 2.2 | tweets | 309007917850435584 |
10.1038/s41558-018-0224-8 | Biology_tweet_199 | Predicted end-of-the-century CO2 levels impair the olfactory system of marine fish, decreasing their chances of detecting food or predators. See the new article in @username Climate Change for more details! #CefasScience @username @username @username | Under elevated CO 2 the responses to l-alanine, l-arginine, l-glutamate, cyprinol sulfate, scymnol sulfate and alarm cue were up to 46% lower than those of controls (n = 6-11 fish per odorant per treatment, P = 0.027, P = 0.040, P = 0.028, P = 0.011, P = 0.012 and P = 0.018, respectively; Fig. | Predicted end-of-the-century CO2 levels impair the olfactory system of marine fish, decreasing their chances of detecting food or predators. See the new article in @username Climate Change for more details! #CefasScience @username @username @username | 3) , but had no effect on the remainder (that is, elevated CO 2 did not increase the amplitude or sensitivity of the response to any of these odorants). Under elevated CO 2 the responses to l-alanine, l-arginine, l-glutamate, cyprinol sulfate, scymnol sulfate and alarm cue were up to 46% lower than those of controls (n... | [2.0, 4.0, 4.0, 3.0, 3.0] | Biology | train | 3.2 | tweets | 1021411224062394370 |
10.1038/s41564-019-0426-5 | Biology_tweet_2 | Wu, Ning, Zhang et al.: Global sampling & #microbiome analysis of #wastewater treatment plants highlights high diversity with a 28 OTU core bacterial community linked to activated sludge performance: | Meta-analyses with global datasets associate the activated sludge microbiomes most closely to freshwater populations. | Wu, Ning, Zhang et al.: Global sampling & #microbiome analysis of #wastewater treatment plants highlights high diversity with a 28 OTU core bacterial community linked to activated sludge performance: | Despite this high diversity, activated sludge has a small, global core bacterial community (n = 28 operational taxonomic units) that is strongly linked to activated sludge performance. Meta-analyses with global datasets associate the activated sludge microbiomes most closely to freshwater populations. In contrast to ma... | [5.0, 3.0, 5.0, 2.0] | Biology | train | 3 | tweets | 1127961946173652992 |
10.1038/s41467-018-07396-3 | Biology_tweet_200 | #Graphene #Nanotech : New research reveals why graphene has not transformed electronics as promised, and shows how to double its performance to finally harness its extraordinary potential - #MaterialsScience #QualityControl | This leads to capacitance values much lower than the theoretical capacitance of graphene (550 F/g) 23 , with values of 409 F/g being the highest reported to date 24 . | #Graphene #Nanotech : New research reveals why graphene has not transformed electronics as promised, and shows how to double its performance to finally harness its extraordinary potential - #MaterialsScience #QualityControl | Moreover, this also indicates the possibility that the as-exfoliated graphene layers can each have different properties, again highlighting the importance of pure 2D materials. This leads to capacitance values much lower than the theoretical capacitance of graphene (550 F/g) 23 , with values of 409 F/g being the highes... | [2.0, 3.0, 1.0, 3.0] | Biology | train | 2.25 | tweets | 1068092481848426496 |
10.1101/gr.171934.113 | Biology_tweet_201 | Ultrarapid cloud-compatible clinical sample NGS bioinformatics pipeline for pathogen identification | In particular, the speed and throughput of the pipeline make it highly convenient and cost-effective when run on a cloud server (Supplemental Table S1 ). | Ultrarapid cloud-compatible clinical sample NGS bioinformatics pipeline for pathogen identification | To our knowledge, SURPI is the only NGS pipeline for pathogen identification to be extensively tested across multiple clinical sample types representing a variety of infectious diseases (Figs. In particular, the speed and throughput of the pipeline make it highly convenient and cost-effective when run on a cloud server... | [5.0, 2.0, 2.0] | Biology | train | 2 | tweets | 474514458438795264 |
10.1016/j.cell.2018.04.034 | Biology_tweet_202 | An Immunogenic Class of #ProstateCancer | CDK12 Inactive | May benefit from #CheckPoint Blockade | Arul Chinnaiyan @username @username | CDK12 mutant cases also lack mutational signatures of HRD ( Figure 3C ) and maintain the expression levels of BRCA1 and BRCA2 ( Figure S4J ). | An Immunogenic Class of #ProstateCancer | CDK12 Inactive | May benefit from #CheckPoint Blockade | Arul Chinnaiyan @username @username | However, our data, and the observations made previously in CDK12 mutant ovarian tumors , are inconsistent with that model. CDK12 mutant cases also lack mutational signatures of HRD ( Figure 3C ) and maintain the expression levels of BRCA1 and BRCA2 ( Figure S4J ). Overall, the genomic phenotypes of HR and CDK12 deficie... | [3.0, 1.0, 3.0, 1.0] | Biology | train | 2 | tweets | 1007459186882605057 |
10.1126/sciadv.1500060 | Biology_tweet_204 | Fighting Crickets Rely on Nitric Oxide #ScienceAdvances | NO's effect is manifested in losers by prolonged avoidance behavior, characteristic for social defeat in numerous species. | Fighting Crickets Rely on Nitric Oxide #ScienceAdvances | Rather than suppressing aggressive motivation, NO increases susceptibility to aversive stimuli and with it the likelihood to flee. NO's effect is manifested in losers by prolonged avoidance behavior, characteristic for social defeat in numerous species. Intriguingly, fighting experience also induces, via NO, a brief su... | [1.0, 4.0, 2.0, 3.0] | Biology | train | 2.5 | tweets | 576442838524801024 |
10.1016/j.stemcr.2018.03.019 | Biology_tweet_206 | Turning any cell of our body into a #StemCell? Yes we can!
➡ How does reprogramming work?
➡ Why does it make male and female cells behave differently?
Find out at or in @username | Together, these results indicate that imprints are not only erased in XX iPSCs but also are not re-established upon global genome remethylation in XO iPSCs, which suggests that female iPSCs, regardless of the number of Xas, may have a similarly poor developmental potential as female ESCs . | Turning any cell of our body into a #StemCell? Yes we can!
➡ How does reprogramming work?
➡ Why does it make male and female cells behave differently?
Find out at or in @username | Here, we found evidence of imprint erasure for the imprint control region of Zrsr1 in female XX and XO iPSCs (Table S2) . Together, these results indicate that imprints are not only erased in XX iPSCs but also are not re-established upon global genome remethylation in XO iPSCs, which suggests that female iPSCs, regardl... | [4.0, 1.0, 1.0, 2.0] | Biology | train | 2 | tweets | 987313503169019904 |
10.14814/phy2.13617 | Biology_tweet_208 | Trouble sleeping? Keep it dark in the evening. | A combination of well-controlled procedures minimizing sources of error variance, a repeated-measures design, and large effect sizes led to several significant findings: (a) 1-h of bright light exposure before bedtime suppresses melatonin by~88%; (b) the effects of evening bright light exposure on melatonin levels pers... | Trouble sleeping? Keep it dark in the evening. | To our knowledge, this study is the first to quantify the melatonin suppression response to evening light exposure in healthy 3-to 5-year-old children. A combination of well-controlled procedures minimizing sources of error variance, a repeated-measures design, and large effect sizes led to several significant findings... | [4.0, 2.0, 3.0, 4.0, 3.0] | Biology | train | 3.2 | tweets | 970867976499970048 |
10.1210/en.2015-2036 | Biology_tweet_209 | @username @username Studies have shown a relationship between low vitamin D and breast cancer.
and there is evidence for the role of vitamin D in autoimmune diseases, as well as other conditions such as Type2 diabetes and CKD. | We validated that Id1 expression was up-regulated in both tumors from vitamin D-deficient mice as well as in the VDR KD cells (Figure 3, A and B) . | @username @username Studies have shown a relationship between low vitamin D and breast cancer.
and there is evidence for the role of vitamin D in autoimmune diseases, as well as other conditions such as Type2 diabetes and CKD. | This 'hit' was of particular interest because of the role of Id1 in BCa progression and most intriguing because calcitriol was found to induce, rather than repress, ID1 expression in a colon carcinoma cell line . We validated that Id1 expression was up-regulated in both tumors from vitamin D-deficient mice as well as i... | [4.0, 1.0, 3.0, 2.0, 3.0] | Biology | train | 2.6 | tweets | 1035148272636182530 |
10.1111/gcb.13526 | Biology_tweet_210 | cool research showing reduced leaf number in soybean plants increases pod yield @username #photosynthesis | Plants with optimal LAI are predicted to use 38% and 39% less carbon in constructing leaf tissue, than for the LAI observed in the field, under current and elevated [CO 2 ], respectively (Fig. | cool research showing reduced leaf number in soybean plants increases pod yield @username #photosynthesis | However, as LAI is lowered below the optimum value, predicted losses in NPP become significant to the detriment of seed production. Plants with optimal LAI are predicted to use 38% and 39% less carbon in constructing leaf tissue, than for the LAI observed in the field, under current and elevated [CO 2 ], respectively (... | [4.0, 1.0, 1.0, 2.0] | Biology | train | 1 | tweets | 799660472228343816 |
10.1073/pnas.1405000111 | Biology_tweet_212 | Let's hit the ground running! How 'bout some science? Neotropical migration may actually have evolved from the north: | PlioPleistocene glaciations have clearly served to modify geographic ranges and migratory distances and routes and may have had an influence on more recent shifts of winter ranges out of North America in the Passerellidae (blue branches, Fig. | Let's hit the ground running! How 'bout some science? Neotropical migration may actually have evolved from the north: | As such, early shifts of winter ranges may not represent invasions of tropical habitats as much as tracking of tropical habitat to lower latitudes to escape harsh winter conditions while maintaining breeding at high latitudes ( . PlioPleistocene glaciations have clearly served to modify geographic ranges and migratory ... | [1.0, 2.0, 3.0, 2.0] | Biology | train | 2 | tweets | 498143012401057792 |
10.1007/s10336-017-1477-0 | Biology_tweet_213 | I spent a month in the Liberian rainforest searching for this bird. Now we know it was never a true species | That the Liberian Greenbul was heterozyogous at none of these positions strongly suggests that it was not an Icterine 9 Spotted Greenbul hybrid. | I spent a month in the Liberian rainforest searching for this bird. Now we know it was never a true species | In contrast, there were 9 single-bp changes and a 2-bp indel between Icterine/Liberian Greenbul sequences and that of Spotted Greenbul. That the Liberian Greenbul was heterozyogous at none of these positions strongly suggests that it was not an Icterine 9 Spotted Greenbul hybrid. The current study has failed to find an... | [1.0, 5.0, 4.0, 5.0, 3.0] | Biology | train | 4 | tweets | 894303427068444673 |
10.1038/s41467-018-04408-0 | Biology_tweet_214 | Nice work in @username on a potential mechanism for the Sex Differences seen in autoimmunity:
Testosterone represses BAFF resulting in lower B cell numbers in men
| Further, a physiological testosterone replacement reduced spleen levels of Baff mRNA in castrated control but not G-ARKO mice (Fig. | Nice work in @username on a potential mechanism for the Sex Differences seen in autoimmunity:
Testosterone represses BAFF resulting in lower B cell numbers in men
| Indeed, Tnfsf13b (Baff) mRNA in the spleen was increased in G-ARKO mice (Fig. Further, a physiological testosterone replacement reduced spleen levels of Baff mRNA in castrated control but not G-ARKO mice (Fig. 3e) ; thus, testosterone downregulates splenic Baff mRNA in an AR-dependent manner. | [4.0, 4.0, 1.0, 1.0] | Biology | train | 3 | tweets | 1004347698168856577 |
10.1126/science.aan2329 | Biology_tweet_216 | Exciting - probably flightless hatchlings and colonial breeding in Hamipterus! | This discovery supports colonial nesting behavior and potential nesting site fidelity in the Pterosauria. | Exciting - probably flightless hatchlings and colonial breeding in Hamipterus! | The geological context, including at least four levels with embryos and eggs, indicates that this deposit was formed by a rare combination of events, with storms acting on a nesting ground. This discovery supports colonial nesting behavior and potential nesting site fidelity in the Pterosauria. The specimens can be att... | [2.0, 4.0, 1.0, 2.0, 3.0] | Biology | train | 2.4 | tweets | 936317637088370688 |
10.1111/oik.03196 | Biology_tweet_217 | Will this new monarch scientific study change the direction of current continental conservation efforts? Have a... | Monarch populations in Spring South significantly predict those in the Midwest. | Will this new monarch scientific study change the direction of current continental conservation efforts? Have a... | 2 Spring South to Midwest Forward selection, Backward selection, and AIC all lead to Model 3, Midwest ⇠ Spring South with the donor region as the only significant predictor (p<0.05). Monarch populations in Spring South significantly predict those in the Midwest. There is no evidence for a temporal trend in this relatio... | [3.0, 1.0, 3.0] | Biology | train | 2.333333 | tweets | 720076984336850944 |
10.1016/j.stemcr.2018.02.011 | Biology_tweet_218 | 'we describe the NeoThy humanized mouse model created using non-fetal human tissue sources, cryopreserved neonatal thymus & umbilical cord blood HSCs'
| The NSG-W host strain's more thorough immuno-depletion and/or use of quickly processed neonatal patient thymic explants may also have influenced our results. | 'we describe the NeoThy humanized mouse model created using non-fetal human tissue sources, cryopreserved neonatal thymus & umbilical cord blood HSCs'
| In contrast, the robust circulating immune cells in the NeoThy are likely due to HSC co-injection coupled with human thymic education in vivo, as described below. The NSG-W host strain's more thorough immuno-depletion and/or use of quickly processed neonatal patient thymic explants may also have influenced our results.... | [2.0, 1.0, 4.0, 2.0] | Biology | train | 2.25 | tweets | 985228715109048320 |
10.1098/rsbl.2017.0299 | Biology_tweet_22 | Frogs in the park: global range expansion did not mean increased net-diversification (HM library can obtain text) | Interestingly, and in striking contrast to expectations, the rapid global range expansion of true frogs was not associated with increased net diversification. | Frogs in the park: global range expansion did not mean increased net-diversification (HM library can obtain text) | We detected no shifts in extinction rates, nor signatures of mass extinction (electronic supplementary material, figure S3 ). Interestingly, and in striking contrast to expectations, the rapid global range expansion of true frogs was not associated with increased net diversification. On the contrary, diversification ra... | [5.0, 5.0, 4.0, 5.0] | Biology | train | 4.75 | tweets | 908267751126585344 |
10.1093/nar/gky1143 | Biology_tweet_220 | Need to relax? This is how DNA gyrase does it @username | Therefore, we suggest that the acute topological problem introduced by replication is primarily dealt with by gyrase enzymes performing processive catalysis to remove (+) supercoils ahead of replication, possibly at a higher rate than 1 supercoil/s, and we speculate that when gyrase fails to remove sufficient (+) super... | Need to relax? This is how DNA gyrase does it @username | In contrast, gyrase can remove (+) supercoils processively in vitro , consistent with our observations that its dwell time significantly increases close to the replisome. Therefore, we suggest that the acute topological problem introduced by replication is primarily dealt with by gyrase enzymes performing processive ca... | [4.0, 1.0, 1.0, 1.0] | Biology | train | 1 | tweets | 1063535215283453953 |
10.1093/molbev/msw148 | Biology_tweet_221 | And is finally out! The evolution of visual pigments and ocular media in snakes | These changes are particularly common among dipsadine and colubrine "higher" snakes. | And is finally out! The evolution of visual pigments and ocular media in snakes | These changes are particularly common among dipsadine and colubrine "higher" snakes. All three opsin genes are inferred to be under purifying selection, though dN/dS varies with respect to some lineages, ecologies, and retinal anatomy. Positive selection was inferred at multiple sites in all three opsins, these being c... | [3.0, 3.0, 2.0] | Biology | train | 2.666667 | tweets | 765788480794419200 |
10.1073/pnas.1409328111 | Biology_tweet_222 | Older mum's have children with more (heteroplasmic) mtDNA mutations.
| Notably, we found a positive association between the number of heteroplasmies in a child and maternal age at fertilization, likely attributable to oocyte aging. | Older mum's have children with more (heteroplasmic) mtDNA mutations.
| mutations per site per year, an order of magnitude higher than for nuclear DNA. Notably, we found a positive association between the number of heteroplasmies in a child and maternal age at fertilization, likely attributable to oocyte aging. Our results can be used to predict the transmission of disease-causing mtDNA va... | [4.0, 5.0, 2.0, 4.0, 1.0] | Biology | train | 4 | tweets | 521814952827310080 |
10.1073/pnas.1613337113 | Biology_tweet_223 | From the Graybiel lab at MIT: using expansion microscopy to reveal integrative units within dopaminergic circuitry. | With new mouse models and tissue expansion to allow nanoscale imaging, we demonstrate that striatonigral fibers originating in striosomes form bouquet-like arborizations innervating clusters of dopamine-containing neurons and their ventrally extending, tightly bundled dendrites. | From the Graybiel lab at MIT: using expansion microscopy to reveal integrative units within dopaminergic circuitry. | In the striosome lines P172-mCitrine and Sepw1-Cre NP67 with the Ai14 reporter (9), the proportion of striosomal fibers to With new mouse models and tissue expansion to allow nanoscale imaging, we demonstrate that striatonigral fibers originating in striosomes form bouquet-like arborizations innervating clusters of dop... | [1.0, 1.0, 4.0, 3.0] | Biology | train | 2 | tweets | 777970964864831488 |
10.1111/gcb.13160 | Biology_tweet_224 | New study shows most US #forests are threatened by #drought & #climatechange:
#UVM prof T. D'Amato is co-author. | Trees may be susceptible to drought-induced growth declines and mortality in two size/density situations, 1) at high-density conditions approaching the maximum size/density relationship, and 2) at low-density conditions conducive to the development of high levels of leaf area that promote canopy and root architecture t... | New study shows most US #forests are threatened by #drought & #climatechange:
#UVM prof T. D'Amato is co-author. | Fire suppression can lead to a 'mesophication' as forest canopies close and may explain why oak regeneration appears to decline relative to that of red (Acer rubrum) and sugar (Acer saccharum) maples in recent decades . Trees may be susceptible to drought-induced growth declines and mortality in two size/density situat... | [4.0, 4.0, 4.0, 3.0, 2.0] | Biology | train | 3.4 | tweets | 701896242268344320 |
10.1093/icesjms/fsw166 | Biology_tweet_227 | Trade offs in marine protection: Higher #lobster numbers in a #MarineReserve reduced other crustacean species | Our findings provide evidence that temperate marine reserves can deliver fisheries and conservation benefits, and highlight the importance of investigating multispecies interactions, as the recovery of some species can have knock-on effects on others. | Trade offs in marine protection: Higher #lobster numbers in a #MarineReserve reduced other crustacean species | Interestingly, catches of adult lobsters were inversely correlated with those of juvenile lobsters, brown crabs, and velvet crabs, which may be evidence of competitive displacement and/or predation. Our findings provide evidence that temperate marine reserves can deliver fisheries and conservation benefits, and highlig... | [4.0, 3.0, 4.0] | Biology | train | 3.666667 | tweets | 783207856120233984 |
10.1053/j.gastro.2013.10.059 | Biology_tweet_228 | Could liver SIRT1 play a key role in #obesity ? This paper certainly suggests so: | Body composition analysis showed that SIRT1 LKO mice had increased fat mass without changed lean mass. | Could liver SIRT1 play a key role in #obesity ? This paper certainly suggests so: | SIRT1 LKO mice appeared to have increased adiposity with more visible fat, possibly due to increased adipocyte cell size. Body composition analysis showed that SIRT1 LKO mice had increased fat mass without changed lean mass. Daily food intake was similar between WT and SIRT1 LKO mice on a regular chow diet. | [3.0, 5.0, 5.0, 4.0, 5.0] | Biology | train | 4.4 | tweets | 426105551081054208 |
10.1073/pnas.1519508113 | Biology_tweet_229 | Not just plants -here's a dromedary history analysis based on seq'g w/modern & old samples & | Given the environmental context in which the wild dromedary would have evolved, it can be assumed that its native distribution and population size were generally quite restricted compared with the ancestral ranges of other livestock species before domestication. | Not just plants -here's a dromedary history analysis based on seq'g w/modern & old samples & | S5 ) and increasingly disjointed before the global extinction of the wild populations less than two millennia after the appearance of the domestic form ) . Given the environmental context in which the wild dromedary would have evolved, it can be assumed that its native distribution and population size were generally qu... | [4.0, 3.0, 1.0, 1.0] | Biology | train | 2 | tweets | 729797197307355136 |
10.1098/rsos.180695 | Biology_tweet_23 | Well, this is fascinating. Climate control allows us to create temp and moisture conditions we feel most comfortable in. So what climate do most Americans "recreate" in their homes? Western Kenya! | North American homes were most similar in climate to the outdoor conditions of west central Kenya (C ¼ 2.938). | Well, this is fascinating. Climate control allows us to create temp and moisture conditions we feel most comfortable in. So what climate do most Americans "recreate" in their homes? Western Kenya! | The value distributions of the climate variables used in the climate dissimilarity index can be viewed in figure 1. North American homes were most similar in climate to the outdoor conditions of west central Kenya (C ¼ 2.938). The mean maximum temperature (average of all seasons) in the North American homes was 25.358C... | [5.0, 5.0, 5.0, 3.0, 5.0] | Biology | train | 4.6 | tweets | 1108466341353308160 |
10.1073/pnas.1511220112 | Biology_tweet_233 | 'most parsimonious model for the evolution of hominin shoulder starts with an African ape-like ancestral state' #PNAS | Moreover, the likelihood of these alternative hypotheses can be directly tested using the better characterized later hominin fossil record. | 'most parsimonious model for the evolution of hominin shoulder starts with an African ape-like ancestral state' #PNAS | This mix of character states raises the question of whether modern human morphology reflects evolution from a more derived African ape morphology or retention of primitive traits from an earlier ape ancestor. Moreover, the likelihood of these alternative hypotheses can be directly tested using the better characterized ... | [2.0, 2.0, 2.0] | Biology | train | 2 | tweets | 641316836009766912 |
10.1038/emi.2013.60 | Biology_tweet_235 | SFV transmission suggests role for human activity,implications for macaque-human coexistence #one health | The towns and villages that constituted research sites for our study are likely similar to hundreds or even thousands of sites throughout Asia, where humans live alongside synanthropic macaques. | SFV transmission suggests role for human activity,implications for macaque-human coexistence #one health | Human/NHP interface in Asia differs from that in Africa The data presented here expand our knowledge of cross-species transmission of SFV in Asia. The towns and villages that constituted research sites for our study are likely similar to hundreds or even thousands of sites throughout Asia, where humans live alongside s... | [1.0, 2.0, 1.0] | Biology | train | 1.333333 | tweets | 377500254389559296 |
10.1038/s41467-017-01957-8 | Biology_tweet_238 | Today's shout-out to #womeninSTEM goes to Dr. Weini Huang @username for her innovative study showing dynamical trade-offs from antagonistic coevolution that decrease intraspecific diversity #microbial ecology #evolution #predatorprey #microbiology | This allowed us to describe the coevolutionary process without imposing a predefined number of prey or predator types. | Today's shout-out to #womeninSTEM goes to Dr. Weini Huang @username for her innovative study showing dynamical trade-offs from antagonistic coevolution that decrease intraspecific diversity #microbial ecology #evolution #predatorprey #microbiology | Such a dynamical trade-off can potentially be important for the evolutionary and the ecological dynamics of species. This allowed us to describe the coevolutionary process without imposing a predefined number of prey or predator types. Consistent with our experiment, starting from naive populations, the trade-off curve... | [1.0, 3.0, 3.0, 1.0, 1.0] | Biology | train | 1.8 | tweets | 940964463787700225 |
10.1186/s13059-018-1616-9 | Biology_tweet_24 | interesting read on how gut bacteria are different between two countries which are both rural. this could be due to their culture that made for these differences. #BS3017 | From this observation, we infer that the gut bacteria are phylogenetically more distinct between groups defined by region (country) than by subsistence practice. | interesting read on how gut bacteria are different between two countries which are both rural. this could be due to their culture that made for these differences. #BS3017 | Comparing the magnitudes of difference between subsistence groups and geographic groups, we therefore find that the bacterial compositional difference between Tanzania and Botswana (a geographic grouping) is larger than between any of the African subsistence groups (both unweighted and weighted UniFrac F-statistics). F... | [3.0, 5.0, 5.0, 4.0, 4.0] | Biology | train | 4.2 | tweets | 1087658103225499651 |
10.1073/pnas.1420819112 | Biology_tweet_240 | metabolic theory and species identity predict reef nutrient cycling | Body nutrient content and trophic position explained little of the variation in E N , E P , or E NP , indicating limited applicability of basic predictors of EST. | metabolic theory and species identity predict reef nutrient cycling | In all cases, including taxonomy in models substantially improved model performance, highlighting the importance of species identity for this ecosystem function. Body nutrient content and trophic position explained little of the variation in E N , E P , or E NP , indicating limited applicability of basic predictors of ... | [3.0, 1.0, 1.0, 1.0] | Biology | train | 1.5 | tweets | 590384086197252096 |
10.1038/s41467-019-08549-8 | Biology_tweet_242 | "...when conditions deteriorate (negative disturbance) groups with high competency in both general and social intelligence are less likely to deplete resources and harvest more" | This does not occur where both g and ToM are high, perhaps signaling the emergence of a more well developed group intelligence. | "...when conditions deteriorate (negative disturbance) groups with high competency in both general and social intelligence are less likely to deplete resources and harvest more" | Groups with high g and low ToM harvest faster and push the resource system closer to its breaking point following a change in resource growth rate. This does not occur where both g and ToM are high, perhaps signaling the emergence of a more well developed group intelligence. Our results are consistent with the idea tha... | [1.0, 1.0, 1.0] | Biology | train | 1 | tweets | 1098387481311891456 |
10.1016/j.celrep.2016.08.013 | Biology_tweet_243 | 👉How #LymeDisease bacteria spread around the body by @username | Therefore, counterintuitively, the small size of bacteria made them less sensitive to force and torque imposed by flow than leukocytes. | 👉How #LymeDisease bacteria spread around the body by @username | Average F s and T s experienced by bacteria were at least 10 times smaller than F s and T s experienced by rolling leukocytes at similar shear stresses , due to the relatively small B. burgdorferi radius. Therefore, counterintuitively, the small size of bacteria made them less sensitive to force and torque imposed by f... | [2.0, 2.0, 2.0, 2.0] | Biology | train | 2 | tweets | 769065624203059200 |
10.1126/scitranslmed.3010760 | Biology_tweet_245 | Another day, another @username contribution to the fight --- tracking the mechanisms of transplant tolerance: | The notion that some, but not all, deletion of donor-reactive clones in tolerant subjects may have reflected repertoire turnover was supported by analysis of third party-reactive T cells identified before transplant ( fig. | Another day, another @username contribution to the fight --- tracking the mechanisms of transplant tolerance: | A significant and sustained reduction in the detection of donor-reactive compared to all CD8 + clones was observed in subjects 2 and 4, suggesting antigen-driven loss of donor-reactive CD8 clones (Fig. The notion that some, but not all, deletion of donor-reactive clones in tolerant subjects may have reflected repertoir... | [3.0, 4.0, 2.0, 1.0] | Biology | train | 2.5 | tweets | 561198663460847618 |
10.1093/beheco/aru103 | Biology_tweet_246 | Artificial night lighting affects dawn and dusk singing in European song birds. Some robins even sing all night! | We cannot exclude that early or late disturbance by humans (e.g., pedestrians, joggers) might have woken up the birds earlier during the weekend or drove the blue tits to be active later at dusk. | Artificial night lighting affects dawn and dusk singing in European song birds. Some robins even sing all night! | High noise levels during the week may reduce the efficiency of communication, and males may compensate by singing more and somewhat earlier during the weekends. We cannot exclude that early or late disturbance by humans (e.g., pedestrians, joggers) might have woken up the birds earlier during the weekend or drove the b... | [2.0, 1.0, 2.0, 3.0] | Biology | train | 2 | tweets | 510499396622905344 |
10.1126/science.aat4082 | Biology_tweet_248 | Hungry plants invite hungry bugs: competition for iron nutrition
| We identify an iron transporter that allows the corn rootworm to benefit from complexes between iron and benzoxazinoids. | Hungry plants invite hungry bugs: competition for iron nutrition
| We show that the root-feeding larvae use complexes between iron and benzoxazinoid secondary metabolites to identify maize as a host, to forage within the maize root system, and to increase their growth. We identify an iron transporter that allows the corn rootworm to benefit from complexes between iron and benzoxazinoi... | [1.0, 3.0, 4.0] | Biology | train | 2 | tweets | 1030151190787645440 |
10.1038/s41467-018-04334-1 | Biology_tweet_249 | Single cell RNAseq from 1053 primary human breast epithelial cells identifies several previously unrealized luminal and basal epithelial subpopulations and a ZEB1-positive basal bi-potent stem/progenitor cells | Understanding the origins of breast cancer in its earliest phases has the potential to advance methods of cancer early detection, and may ultimately form the basis to prevent cancer progression before it turns into a life-threatening disease. | Single cell RNAseq from 1053 primary human breast epithelial cells identifies several previously unrealized luminal and basal epithelial subpopulations and a ZEB1-positive basal bi-potent stem/progenitor cells | Instead, the outcome of our Monocle analysis is in favor of the existence of the bi-potent stem/progenitor model as it clearly identified one continuous trajectory indicative of a common source for both basal and luminal cell differentiation. Understanding the origins of breast cancer in its earliest phases has the pot... | [4.0, 2.0, 3.0, 3.0, 3.0] | Biology | train | 3 | tweets | 999245589484396544 |
10.1016/j.neuron.2017.06.028 | Biology_tweet_250 | The PNN protein Brevican modulates cellular and synaptic plasticity in PV+ cells | Hence, the identification of the relevant molecular mediators of this form of plasticity may offer novel therapeutic strategies to recover from deficits in perception, learning, and memory associated with a repertoire of diseases. | The PNN protein Brevican modulates cellular and synaptic plasticity in PV+ cells | By simultaneously regulating the excitatory inputs and firing properties of PV+ cells, a perineuronal net protein drives PV+ interneuron wiring as well as network adaptation to experience. Hence, the identification of the relevant molecular mediators of this form of plasticity may offer novel therapeutic strategies to ... | [4.0, 2.0, 1.0, 1.0] | Biology | train | 2 | tweets | 886969444064481280 |
10.1016/j.cell.2015.07.058 | Biology_tweet_253 | Getting ready to read this fresh article sounds exciting! @username #virus #DNArepair | MRN senses and binds to early replicating virus genomes where it recruits ATM and activates a localized signaling response that selectively prevents virus genome replication. | Getting ready to read this fresh article sounds exciting! @username #virus #DNArepair | The localized MRN-ATM response provides an elegant mechanism to selectively neutralize viral replication without jeopardizing cellular replication and viability. MRN senses and binds to early replicating virus genomes where it recruits ATM and activates a localized signaling response that selectively prevents virus gen... | [1.0, 2.0, 1.0] | Biology | train | 1.333333 | tweets | 636979929016631296 |
10.1038/s41467-018-04151-6 | Biology_tweet_254 | There are a surprisingly limited number of ways a network could be constructed to perform perfect adaptation. #cellcommunication #nature #networks | This has important implications for the interconnections of the module with other parts of the RPA-capable network. | There are a surprisingly limited number of ways a network could be constructed to perform perfect adaptation. #cellcommunication #nature #networks | The single independent regulator of each opposer node, and its dependents (all marked in green) do exhibit the RPA property. This has important implications for the interconnections of the module with other parts of the RPA-capable network. The symbol S N indicates that any motif or sub-network may be fully embedded at... | [3.0, 2.0, 4.0, 2.0] | Biology | train | 2.75 | tweets | 991934061500424192 |
10.1016/j.cell.2014.12.038 | Biology_tweet_256 | Copy-number variations in #microbiome of #human gut From Borenstein lab @username | Notably though, we did not detect significantly more variation in clusters for which more reference genomes were available. | Copy-number variations in #microbiome of #human gut From Borenstein lab @username | First, our analysis is limited to the detection of variation in gut species for which at least one fully sequenced genome is available, and future studies may benefit from additional genomes. Notably though, we did not detect significantly more variation in clusters for which more reference genomes were available. In a... | [1.0, 2.0, 1.0, 1.0] | Biology | train | 1.25 | tweets | 560916396356300801 |
10.1016/j.cell.2015.02.011 | Biology_tweet_257 | New potential treatment for JAK2 based MPNs arising from selective re-orientation of defected EPO receptors #Science | However, dimer reorientation could be achieved by many different types of engineered scaffolds. | New potential treatment for JAK2 based MPNs arising from selective re-orientation of defected EPO receptors #Science | This strategy is applicable to diseases mediated by mutated, constitutively active receptors and could offer the advantage of specificity and reduced toxicity versus broadly neutralizing kinase inhibitors. However, dimer reorientation could be achieved by many different types of engineered scaffolds. A range of altered... | [1.0, 4.0, 1.0, 1.0] | Biology | train | 1 | tweets | 577605770856022016 |
10.1086/693564 | Biology_tweet_258 | Updated estimation of the the number of species suggests that the Creator has an inordinate fondness for bacteria.
| We readily acknowledge that the free-living biodiversity of soils may also be extensive, and its inclusion might change our estimates somewhat. | Updated estimation of the the number of species suggests that the Creator has an inordinate fondness for bacteria.
| Second, in some groups we did not include estimates of their free-living diversity, especially in soils (e.g., mites, nematodes, protists, and bacteria). We readily acknowledge that the free-living biodiversity of soils may also be extensive, and its inclusion might change our estimates somewhat. However, additions of ... | [2.0, 1.0, 2.0] | Biology | train | 1.666667 | tweets | 900994170445287425 |
10.1038/s41588-019-0405-z | Biology_tweet_259 | And here is the next #peanut genome paper in @username from #IPGI @username showing single origin for cultivated peanut & its wild counterpart A. monticola. We together with @username contributed #HiC assembly to this work. @username @username | Within genes, the B subgenome was enriched relative to the A subgenome for DNA sequences that corresponded to small RNAs ( Supplementary Fig. | And here is the next #peanut genome paper in @username from #IPGI @username showing single origin for cultivated peanut & its wild counterpart A. monticola. We together with @username contributed #HiC assembly to this work. @username @username | However, greater densities of DNA sequences that corresponded to uniquely mapping small RNAs were found in gene-rich chromosomal regions ( Supplementary Fig. Within genes, the B subgenome was enriched relative to the A subgenome for DNA sequences that corresponded to small RNAs ( Supplementary Fig. As has been reporte... | [1.0, 2.0, 2.0, 1.0, 1.0] | Biology | train | 1.4 | tweets | 1123612112490598400 |
10.1073/pnas.1219361110 | Biology_tweet_26 | Larger penis size and greater height have almost equivalent effects on male attractiveness. | Our results support the hypothesis that female mate choice could have driven the evolution of larger penises in humans. | Larger penis size and greater height have almost equivalent effects on male attractiveness. | Surprisingly, larger penis size and greater height had almost equivalent positive effects on male attractiveness. Our results support the hypothesis that female mate choice could have driven the evolution of larger penises in humans. More broadly, our results show that precopulatory sexual selection can play a role in ... | [4.0, 2.0, 3.0, 4.0, 2.0] | Biology | train | 3 | tweets | 321347885633531904 |
10.1038/s41467-017-00962-1 | Biology_tweet_260 | Our paper with Hopkins providing genomic evidence that many ovarian cancers start in the fallopian tube. @username | As expected, we identified sequence changes in the TP53 tumor suppressor gene, a wellknown driver gene in HGSOC, in all cases. | Our paper with Hopkins providing genomic evidence that many ovarian cancers start in the fallopian tube. @username | Whole-exome sequence analyses of the tumor samples from each patient identified somatic mutations that were present in all neoplastic samples analyzed as well as specific changes that were present in individual or subsets of tumors (Fig. As expected, we identified sequence changes in the TP53 tumor suppressor gene, a w... | [2.0, 2.0, 1.0] | Biology | train | 1.666667 | tweets | 922415510591098881 |
10.1002/ajp.22168 | Biology_tweet_261 | Just Published: Developing a questionnaire to measure chimpanzee personality via top-down/bottom-up design | There was a positive correlation between play behavior and Openness, as has been found previously for the trait "curious" . | Just Published: Developing a questionnaire to measure chimpanzee personality via top-down/bottom-up design | Openness, which includes traits such as intelligent, inquisitive, human oriented, and inventive, had mixed predictive validity. There was a positive correlation between play behavior and Openness, as has been found previously for the trait "curious" . However, with Openness, there was also a positive correlation with s... | [1.0, 2.0, 1.0] | Biology | train | 1.333333 | tweets | 392365762444144640 |
10.1038/s41467-017-00525-4 | Biology_tweet_262 | Researchers Slow Aging and Extend Lifespan of Fruit Flies #science | Critically, short-term, midlife induction of Drp1 improves proteostasis in aged animals. | Researchers Slow Aging and Extend Lifespan of Fruit Flies #science | Taken together, our findings reveal that the midlife shift toward more elongated mitochondria, in flight muscle, contributes to age-onset proteotoxicity. Critically, short-term, midlife induction of Drp1 improves proteostasis in aged animals. RU486 had no significant impact on the accumulation of protein aggregates in ... | [3.0, 4.0, 1.0, 4.0] | Biology | train | 3 | tweets | 905420468202721280 |
10.3389/fphar.2013.00071 | Biology_tweet_263 | Sweet...The effects of cocoa on the immune system | The primary function of Th17 cells appears to be the clearance of pathogens that are not adequately handled by Th1 or Th2 cells and they are potent inducers of tissue inflammation ( . | Sweet...The effects of cocoa on the immune system | After naïve Th cell activation and proliferation, effector Th lymphocytes appear. The primary function of Th17 cells appears to be the clearance of pathogens that are not adequately handled by Th1 or Th2 cells and they are potent inducers of tissue inflammation ( . No changes in the secretion of this cytokine were obse... | [2.0, 2.0, 2.0, 1.0, 2.0] | Biology | train | 1.8 | tweets | 345289329435889664 |
10.1038/ncomms4632 | Biology_tweet_264 | Nanotech rising..
| The demonstration of nanomotors for biochemical release as shown above is still in a non-bioenvironment. | Nanotech rising..
| Such molecule release mechanism is applicable not only to Raman-sensitive molecules but also to any biochemicals of interests, such as drugs, cytokine, DNA, antigens and antibodies. The demonstration of nanomotors for biochemical release as shown above is still in a non-bioenvironment. More experiments are necessary to... | [2.0, 1.0, 2.0] | Biology | train | 1.666667 | tweets | 469374649865093120 |
10.1016/j.immuni.2019.05.007 | Biology_tweet_265 | Great paper by Lindesmith et al mapping antibody responses after norovirus immunization. Amazing how little we know about a virus that kills so many @username #norovirus | A1431 had very extensive breadth and potency not only towards all historical strains available but also towards prospective GII.4 strains that appeared after the vaccine trial, including GII.4 2012 and 2015, neither of which had circulated in the general population at the time of sample collection ( Figure 2B ). | Great paper by Lindesmith et al mapping antibody responses after norovirus immunization. Amazing how little we know about a virus that kills so many @username #norovirus | Finally, the third class of serum antibodies had a single member, A1431, which had strong blockade activity to all known historical GII.4 strains from 1987 onwards. A1431 had very extensive breadth and potency not only towards all historical strains available but also towards prospective GII.4 strains that appeared aft... | [1.0, 4.0, 2.0, 1.0] | Biology | train | 2 | tweets | 1141051718144335872 |
10.1073/pnas.1301764110 | Biology_tweet_266 | Tfr1 as an HCV entry factor (PNAS) (sub) #mondaymicro | Although not a robust assay, analogous to previous reports, we observed a threefold increase in HCVcc binding to CHO cells expressing human SRBI than to parental CHO cells, and this binding was more pronounced than that detected on CHO cells expressing CD81. | Tfr1 as an HCV entry factor (PNAS) (sub) #mondaymicro | HCV Particle Binds to TfR1. Although not a robust assay, analogous to previous reports, we observed a threefold increase in HCVcc binding to CHO cells expressing human SRBI than to parental CHO cells, and this binding was more pronounced than that detected on CHO cells expressing CD81. Likewise, CHO cells expressing Tf... | [3.0, 2.0, 5.0] | Biology | train | 2 | tweets | 344208265288220673 |
10.1126/scitranslmed.3008325 | Biology_tweet_267 | [Research Articles] Closed-loop neuromodulation of spinal sensorimotor circuits controls… | Animals with complete spinal cord injury performed more than 1000 successive steps without failure, and were able to climb staircases of various heights and lengths with precision and fluidity. | [Research Articles] Closed-loop neuromodulation of spinal sensorimotor circuits controls… | These developments allowed us to conceive a neuroprosthetic system that controlled a broad range of foot trajectories during continuous locomotion in paralyzed rats. Animals with complete spinal cord injury performed more than 1000 successive steps without failure, and were able to climb staircases of various heights a... | [1.0, 4.0, 2.0, 2.0, 2.0] | Biology | train | 2.2 | tweets | 514850371085152256 |
10.1111/j.1752-8062.2011.00370.x | Biology_tweet_269 | I promised for an animal model that develop hypercholesterolemia induced by state of fat adaptation, here's this animal model, the animal was the hibernating Brown Bears.
@username @username @username @username | This species might serve as a reverse translational model for atherosclerosis resistance. | I promised for an animal model that develop hypercholesterolemia induced by state of fat adaptation, here's this animal model, the animal was the hibernating Brown Bears.
@username @username @username @username | Brown bears tolerate elevated cholesterol levels, obesity, physical inactivity, and circulatory slow fl ow during hibernation without signs of atherosclerosis. This species might serve as a reverse translational model for atherosclerosis resistance. Th e experimental design of recaptuing provides controls for both inte... | [1.0, 1.0, 1.0, 2.0] | Biology | train | 1.25 | tweets | 1008749330373791744 |
10.1038/s41467-018-06236-8 | Biology_tweet_27 | Roundworm study documents paternal transmission of epigenetic memory via sperm About 10 percent of histone packaging is retained in both human and mouse sperm. #epigenetics #hereditary #biology #genetics @username @username | The finding that abnormal retention of an epigenetic memory of spermatogenesis compromises germline health 36 suggests that sperm epigenetic marking must be reset each generation. | Roundworm study documents paternal transmission of epigenetic memory via sperm About 10 percent of histone packaging is retained in both human and mouse sperm. #epigenetics #hereditary #biology #genetics @username @username | We speculate that multivalent marking in C. elegans sperm serves a different function than in zebrafish and mammalian sperm, namely to enable an epigenetic memory of spermatogenesis to be reset. The finding that abnormal retention of an epigenetic memory of spermatogenesis compromises germline health 36 suggests that s... | [3.0, 4.0, 4.0, 2.0, 3.0] | Biology | train | 3.2 | tweets | 1052537409467023360 |
10.1038/s41598-019-42251-5 | Biology_tweet_270 | Scientists have discovered an entirely new class of cancer-killing agents that show promise in eradicating cancer stem cells. Their findings could prove to be a breakthrough in not only treating tumors, but ensuring cancer doesn't return years later. | E-Cadherin expressing NCI-H522 cells exhibited an epithelial growth pattern in vitro, unlike the parental cells, which showed less cell-cell contact (Fig. | Scientists have discovered an entirely new class of cancer-killing agents that show promise in eradicating cancer stem cells. Their findings could prove to be a breakthrough in not only treating tumors, but ensuring cancer doesn't return years later. | Sensitivity to paclitaxel, etoposide, imatinib and gefitinib did not correlate with vimentin expression (Fig. E-Cadherin expressing NCI-H522 cells exhibited an epithelial growth pattern in vitro, unlike the parental cells, which showed less cell-cell contact (Fig. Exposure of reconstituted cells to either U0126 or 4 di... | [1.0, 2.0, 1.0, 1.0] | Biology | train | 1.25 | tweets | 1148946853062299648 |
10.1016/j.cell.2016.09.056 | Biology_tweet_271 | See! I told you they were important. And congratulations to Steve Blacklow for igniting the tetraspanin field.
| Our molecular dynamics simulations suggest that CD81 may exist in both closed and open conformations and that the equilibrium between closed and open conformations may be shifted toward the closed state when cholesterol is bound. | See! I told you they were important. And congratulations to Steve Blacklow for igniting the tetraspanin field.
| Our results reveal that CD81 binds cholesterol and that E219 is an important residue in the binding pocket, offering a potential mechanism for how tetraspanins might detect cholesterol or other membrane lipids (whereas CD81 and tspan10 both possess a polar residue in this position, most other tetraspanins have a polar ... | [1.0, 1.0, 1.0] | Biology | train | 1 | tweets | 791998144724729856 |
10.1038/nature09273 | Biology_tweet_272 | RT @username More common rainforest trees are less susceptible to soil-based pathogens. Neat! #Biodiversity … | Both experiments provide strong evidence for negative plant-soil feedback mediated by soil biota. | RT @username More common rainforest trees are less susceptible to soil-based pathogens. Neat! #Biodiversity … | Such patterns of density and distance dependence are expected to emerge if the process of enemy-mediated negative feedback is operating in the plant community. Both experiments provide strong evidence for negative plant-soil feedback mediated by soil biota. In contrast, above-ground enemies (mammals, foliar herbivores ... | [4.0, 5.0, 2.0, 1.0, 3.0] | Biology | train | 2 | tweets | 515180354681192449 |
10.1038/srep01456 | Biology_tweet_273 | I could not resist this. | Bed bugs injected with dsRNA of malE or target genes suffered ,10% mortality within 6 days after injection. | I could not resist this. | Moreover, among 21 field bed bug populations tested, 100% of populations were associated with at least two molecular mechanisms (not including LA-1 the reference population), implying the prevalent involvement of multiple mechanisms of pyrethroid resistance in the field bed bug populations. Bed bugs injected with dsRNA... | [1.0, 1.0, 1.0, 1.0, 1.0] | Biology | train | 1 | tweets | 420129662275039232 |
10.1073/pnas.1507055113 | Biology_tweet_274 | The real Paleo diet: what did our ancestors eat for dinner? Congrats to Clay Magill on his new paper in PNAS! | In the farthest southeastern (FLK S ) trenches, high C/V values and high δ 13 C values for C lignin phenols (Fig. | The real Paleo diet: what did our ancestors eat for dinner? Congrats to Clay Magill on his new paper in PNAS! | 3 and 4A ) collectively indicate dense woody cover (Fig. In the farthest southeastern (FLK S ) trenches, high C/V values and high δ 13 C values for C lignin phenols (Fig. Biomarkers define a heterogeneous landscape at Olduvai and suggest an influence of local resources on hominin diets and behavior. | [1.0, 1.0, 1.0] | Biology | train | 1 | tweets | 701908541242798080 |
10.1016/j.cub.2007.01.061 | Biology_tweet_275 | #NYK That rats, like dolphins and humans, are thought to have metacognition, the awareness of your ability to think. | The other aperture (referred to as the decline-the-test response) led to the omission of the duration test. | #NYK That rats, like dolphins and humans, are thought to have metacognition, the awareness of your ability to think. | By contrast, more widely spaced intervals (e.g., 2 and 8 s) are easiest to classify. The other aperture (referred to as the decline-the-test response) led to the omission of the duration test. In the test phase, a correct lever press with respect to the duration discrimination produced a large reward of six pellets; an... | [1.0, 1.0, 1.0, 2.0] | Biology | train | 1.25 | tweets | 876311778724020224 |
10.1126/sciadv.1601660 | Biology_tweet_276 | A common problem in flexography is dot gain during impression, but some amazing advances are being made to improve resolution with nanoporous microstructures. @username #gc3400
| When this stamp is used to print, the excess ink spreads upon contact, resulting in greater width and corner roundness of the printed features compared to the stamp and an overall loss of pattern fidelity ( fig. | A common problem in flexography is dot gain during impression, but some amazing advances are being made to improve resolution with nanoporous microstructures. @username #gc3400
| However, we find that a slight amount of excess ink is present on the stamp surface. When this stamp is used to print, the excess ink spreads upon contact, resulting in greater width and corner roundness of the printed features compared to the stamp and an overall loss of pattern fidelity ( fig. When the CNT stamp is t... | [2.0, 1.0, 1.0, 2.0, 2.0] | Biology | train | 1.6 | tweets | 1044630850992779275 |
10.1016/j.mito.2018.08.001 | Biology_tweet_277 | @username @username Naviaux's paper I mentioned above: | Over 100 chronic illnesses can be classified according to the stage of the CDR that is blocked (Table 1) . | @username @username Naviaux's paper I mentioned above: | The savings in a single year would be more than the annual budgets of the National Institutes of Health (NIH; $37 billion), Environmental Protection Agency (EPA; $8.7 billion), Food and Drug Administration (FDA; $5.1 billion), and the US Department of Agriculture (USDA; $151 billion) combined. Over 100 chronic illnesse... | [2.0, 1.0, 1.0, 1.0, 1.0] | Biology | train | 1.2 | tweets | 1031941304387821570 |
10.1126/sciadv.1700581 | Biology_tweet_278 | Flooding dominates news but new research shows Jordan faces new 25 droughts per 30 year cycle compared to 8 now | These impacts are especially worth considering for the 278 transboundary waterways (37) associated with shared watersheds occupying nearly half of the world's land . | Flooding dominates news but new research shows Jordan faces new 25 droughts per 30 year cycle compared to 8 now | Water security assessments spanning future decades would greatly benefit from reflecting on the joint impacts of multiple drought types and humaninduced land-use change. These impacts are especially worth considering for the 278 transboundary waterways (37) associated with shared watersheds occupying nearly half of the... | [3.0, 3.0, 1.0, 1.0, 1.0] | Biology | train | 1.8 | tweets | 903511598232477696 |
10.1038/s41467-018-04251-3 | Biology_tweet_279 | Further reading: | The EP degeneracy featured by zero scattering eigenvalue splitting is designed at 632.8 nm by optimizing the respective thicknesses of Au and PMMA layers. | Further reading: | Spatially resolved thermal mapping. The EP degeneracy featured by zero scattering eigenvalue splitting is designed at 632.8 nm by optimizing the respective thicknesses of Au and PMMA layers. The abrupt EP phase transition can be fully characterized by the quasi-linear response of forward reflection with almost negligib... | [2.0, 1.0, 1.0, 1.0] | Biology | train | 1.25 | tweets | 991765852956524544 |
10.1073/pnas.1504869112 | Biology_tweet_28 | Lianas: reducing carbon gain and storage in tropical forests @username @username @username | These studies indicated that the presence of lianas can reduce stand-level biomass growth by ∼10% and net forest biomass accumulation by up to 18% and that forest carbon stocks decrease with increasing liana abundance ( . | Lianas: reducing carbon gain and storage in tropical forests @username @username @username | The increase in lianas, combined with the observations that lianas can reduce individual tree growth by up to 84% and increase tree mortality risk two-to three-fold , has made it pertinent to investigate the effect of lianas on forest-level biomass dynamics to better predict the effect of increasing liana abundance on ... | [4.0, 4.0, 4.0, 3.0, 2.0] | Biology | train | 3.4 | tweets | 654223530092052480 |
10.1016/j.neuron.2018.12.026 | Biology_tweet_280 | "These findings suggest E-I ratio changes are compensatory in autism." We've got a game-changer here...... | Averaging across WT cells revealed a smooth contour of G ex /G in scaling combinations that predict no change in PSP peak (PSP diff = 0), which we term the ''PSP stability contour'' ( Figure 3D , thick contour). | "These findings suggest E-I ratio changes are compensatory in autism." We've got a game-changer here...... | Instead, equal weakening of G ex and G in reduces PSP peak, and further weakening of G in restores it (example cell, Figure 3C ). Averaging across WT cells revealed a smooth contour of G ex /G in scaling combinations that predict no change in PSP peak (PSP diff = 0), which we term the ''PSP stability contour'' ( Figure... | [3.0, 3.0, 1.0, 1.0, 1.0] | Biology | train | 1.8 | tweets | 1087909946073612288 |
10.4049/jimmunol.1400569 | Biology_tweet_281 | A new treatment for #gumdisease? (£) | These data show that C3 is required for maximal inflammation and bone loss in P. gingivalis-induced periodontitis in mice. | A new treatment for #gumdisease? (£) | 1B and 1C, respectively) . These data show that C3 is required for maximal inflammation and bone loss in P. gingivalis-induced periodontitis in mice. Consistent with its ability to activate C5aR independently of the canonical activation of the complement cascade, P. gingivalis retained its capacity to colonize the peri... | [3.0, 3.0, 3.0] | Biology | train | 3 | tweets | 490817207090548736 |
10.1016/j.cmet.2017.08.006 | Biology_tweet_282 | Blankets and L-Carnitine For Grandparents To Stay Warm #fuelingtactics | HNF4α binding peaks were observed in proximity to promoters of PPARα, Cpt1b, Octn2, and CrAT ( Figure 5F ). | Blankets and L-Carnitine For Grandparents To Stay Warm #fuelingtactics | Although Cpt1 and Cpt2 regulation by HNF4α is well established, we also observed reduction in Octn2 and CrAT expression in the livers of hepatocyte-selective HNF4α null mice . HNF4α binding peaks were observed in proximity to promoters of PPARα, Cpt1b, Octn2, and CrAT ( Figure 5F ). Together these findings suggest that... | [1.0, 1.0, 2.0, 1.0] | Biology | train | 1.25 | tweets | 905439179475169280 |
10.1007/s00244-015-0196-x | Biology_tweet_283 | This is a really interesting paper demonstrating exposure of bats to pharmaceuticals and other emerging contaminants | Infusion of prostaglandin PGE 2 into the brains of hibernating golden-mantled ground squirrels (Spermophilus lateralis) caused periodic arousals along with increased body temperature . | This is a really interesting paper demonstrating exposure of bats to pharmaceuticals and other emerging contaminants | In Asian chipmunks (Tamias asiaticus), prostaglandin PGD 2 increased in the brain to a maximum in February and declined by April suggesting a correlation between PGD 2 and hibernation . Infusion of prostaglandin PGE 2 into the brains of hibernating golden-mantled ground squirrels (Spermophilus lateralis) caused periodi... | [2.0, 1.0, 1.0, 1.0] | Biology | train | 1.25 | tweets | 629322328791453696 |
10.1073/pnas.1702798114 | Biology_tweet_284 | Our latest paper on using antibiofilm glycoside hydrolases (PelA and Sph3) with animal model just out in @username | Biofilm disruption was associated with a marked reduction in hyphae-associated GAG as detected by lectin staining (Fig. | Our latest paper on using antibiofilm glycoside hydrolases (PelA and Sph3) with animal model just out in @username | Treatment with Sph3 h for 1 h disrupted established A. fumigatus biofilms with an effective concentration for 50% activity (EC 50 ) of 0.45 ± 1.31 nM (Fig. Biofilm disruption was associated with a marked reduction in hyphae-associated GAG as detected by lectin staining (Fig. A catalytic variant Sph3 h D166A, which does... | [3.0, 1.0, 2.0, 2.0] | Biology | train | 2 | tweets | 877342873104117760 |
10.1038/s41467-018-04906-1 | Biology_tweet_285 | the fingerprint sensor
its activator domain contains the sites for function in multiple contexts despite the sixth finger👆lead to a hypothesized network of contextual connections
and the region near basic tail shares.\ The transactivation domain... | This enabled the fine patterns of transparent electrodes required in fingerprint sensors that need to detect the period between the ridges and valleys of human fingers (~100 μm) . | the fingerprint sensor
its activator domain contains the sites for function in multiple contexts despite the sixth finger👆lead to a hypothesized network of contextual connections
and the region near basic tail shares.\ The transactivation domain... | On the other hand, the AgNF-AgNW hybrid structure exhibited a negligible dependence of R s on the pattern widths, and it had a significantly low R s even for narrow patterns with widths <100 μm. This enabled the fine patterns of transparent electrodes required in fingerprint sensors that need to detect the period betwe... | [4.0, 4.0, 3.0] | Biology | train | 3.666667 | tweets | 1018216740050726912 |
10.1038/ncomms14514 | Biology_tweet_286 | "Liquid-like" semiconductor clusters from my group | This mode hardening indicates the presence of a compressive strain in the NCs, which increases in magnitude with decreasing size. | "Liquid-like" semiconductor clusters from my group | 5) . This mode hardening indicates the presence of a compressive strain in the NCs, which increases in magnitude with decreasing size. It must, however, be acknowledged that the LO phonon frequency can shift also due to the effect of phonon confinement in small crystallites, as shown by the classic work of Richter et a... | [1.0, 1.0, 1.0, 2.0, 1.0] | Biology | train | 1.2 | tweets | 833706813069598720 |
10.1186/s12896-018-0443-0 | Biology_tweet_287 | @username bc i read your tweet about gluten. saw this article 2mins ago : Possible to buy medics against celiac desease in 2021~ | The SDS gel showed four dominant protein bands, which all contained the refolded product. | @username bc i read your tweet about gluten. saw this article 2mins ago : Possible to buy medics against celiac desease in 2021~ | 4) . The SDS gel showed four dominant protein bands, which all contained the refolded product. Host cell proteins were only found to a small portion in the lowest band, indicating a high purity of the refolded product. | [1.0, 1.0, 1.0, 1.0, 1.0] | Biology | train | 1 | tweets | 1046202273490243584 |
10.1016/j.neuron.2018.12.026 | Biology_tweet_288 | Autism animal model zoo news: that elevated E-I ratio in your autistic (Fmr1-/y, Cntnap2−/−, 16p11.2 del/+, Tsc2+/−) mice? It's compensatory | Fmr1 À/y mice show faster or broader spread of sensory-evoked activity in S1, suggesting a blurred whisker map (Arnett et al., 2014; , which we also observed in the form of increased tuning heterogeneity in each S1 column. | Autism animal model zoo news: that elevated E-I ratio in your autistic (Fmr1-/y, Cntnap2−/−, 16p11.2 del/+, Tsc2+/−) mice? It's compensatory | Thus, increased cortical spiking is not broadly observed in ASD genotypes. Fmr1 À/y mice show faster or broader spread of sensory-evoked activity in S1, suggesting a blurred whisker map (Arnett et al., 2014; , which we also observed in the form of increased tuning heterogeneity in each S1 column. A simple synaptic cond... | [2.0, 2.0, 1.0, 3.0] | Biology | train | 2 | tweets | 1087505256383156226 |
10.1016/j.cub.2018.06.016 | Biology_tweet_29 | Zebrafish are social. Check out this awesome paper about how they identified what neurons in the brain are responsible! | Our data show that social engagement in zebrafish requires a behavioral visual stimulus provided by another socially engaged fish. | Zebrafish are social. Check out this awesome paper about how they identified what neurons in the brain are responsible! | Based on their anatomical location and gene expression patterns, these cells may be homologous to a population of lhx8-expressing, cholinergic basal forebrain neurons that is also found in mammals . Our data show that social engagement in zebrafish requires a behavioral visual stimulus provided by another socially enga... | [4.0, 5.0, 2.0] | Biology | train | 4 | tweets | 1022584174065082369 |
10.1073/pnas.1219361110 | Biology_tweet_290 | Size matters. Penis size and attraction correlations. | Our results support the hypothesis that female mate choice could have driven the evolution of larger penises in humans. | Size matters. Penis size and attraction correlations. | Surprisingly, larger penis size and greater height had almost equivalent positive effects on male attractiveness. Our results support the hypothesis that female mate choice could have driven the evolution of larger penises in humans. More broadly, our results show that precopulatory sexual selection can play a role in ... | [3.0, 5.0, 4.0, 2.0] | Biology | train | 3.5 | tweets | 322099951318495232 |
10.1098/rsbl.2014.0993 | Biology_tweet_292 | Poetic study: At night, the many pollination drops glitter like diamonds in the full moonlight | To experimentally remove the forces of celestial gravitation is difficult but our hypothesis could be further tested by experiments on moonlight detection in plants and by continuing to make predictions followed by targeted observations . | Poetic study: At night, the many pollination drops glitter like diamonds in the full moonlight | The full moon is thus important for efficient pollination of E. foeminea both for pollinator navigation in the dark and for attraction to the cones. To experimentally remove the forces of celestial gravitation is difficult but our hypothesis could be further tested by experiments on moonlight detection in plants and by... | [1.0, 1.0, 1.0, 2.0, 2.0] | Biology | train | 1.4 | tweets | 595976864704921602 |
10.1126/scitranslmed.aaa8419 | Biology_tweet_293 | Hyperammonemia syndrome from Ureaplasma infection (and other causes) in transplant patients, latest learnings from @username ! 🌟Click the thread to read the entire entry and to go back to the original question. 📌#meded #transplant @username @username @username 💡 | We performed PCR and found that residual BAL fluid and blood collected shortly before his death were positive for both M. hominis and U. parvum. | Hyperammonemia syndrome from Ureaplasma infection (and other causes) in transplant patients, latest learnings from @username ! 🌟Click the thread to read the entire entry and to go back to the original question. 📌#meded #transplant @username @username @username 💡 | This patient was shown to have systemic M. hominis infection . We performed PCR and found that residual BAL fluid and blood collected shortly before his death were positive for both M. hominis and U. parvum. On postoperative day 12, he developed mental status changes, and his ammonia concentration was 549 mM. | [3.0, 1.0, 1.0] | Biology | train | 1.666667 | tweets | 1071076147096682498 |
10.1098/rsos.171474 | Biology_tweet_294 | Look, video games don't kill people, #guns kill people. There have been 4 studies showing NO evidence that violent video games lead to violence ( #GunConrolNow | Measurement flexibility also extends to a number of outcome assessments employed in the gaming literature. | Look, video games don't kill people, #guns kill people. There have been 4 studies showing NO evidence that violent video games lead to violence ( #GunConrolNow | Such a pattern could lead researchers to make the spurious claim that playing the 2004 Xbox game Spider Man 2 is a significant catalyst for adolescent promiscuity . Measurement flexibility also extends to a number of outcome assessments employed in the gaming literature. A similar tractability is present in behavioural... | [1.0, 2.0, 1.0, 1.0] | Biology | train | 1.25 | tweets | 1159861083047260160 |
10.1038/s41590-018-0068-4 | Biology_tweet_295 | New paper from our lab out today in @username showing how #vitaPAMP recognition via TLR8 promotes #TFHcell differentiation & #vaccine responses.
Free full text
| Further subgroup analysis revealed that distribution of the TLR8 allele was in fact significantly different only for subjects who had previously received the live BCG vaccine against TB (P = 0.002), whereas its distribution was not significantly different for unvaccinated subjects (P = 0.754) (Fig. | New paper from our lab out today in @username showing how #vitaPAMP recognition via TLR8 promotes #TFHcell differentiation & #vaccine responses.
Free full text
| 8a and Supplementary Table 3 ), indicative of a protective effect of TLR8-G against PTB, as has been reported 32 . Further subgroup analysis revealed that distribution of the TLR8 allele was in fact significantly different only for subjects who had previously received the live BCG vaccine against TB (P = 0.002), wherea... | [3.0, 5.0, 5.0] | Biology | train | 4.333333 | tweets | 975784883288203264 |
10.1038/nature24621 | Biology_tweet_296 | Wow, full-throated endorsement that "Exact sequence variants should replace OTUs..." in the EMP paper! | While earlier largescale 16S rRNA amplicon studies adopted OTU clustering approaches in part out of concern that erroneous reads would dominate diversity assessments 23 , patterns of prevalence (presenceabsence) in our results suggest that Deblur error removal produced ecologically informative sequences without cluster... | Wow, full-throated endorsement that "Exact sequence variants should replace OTUs..." in the EMP paper! | Because exact sequences are stable identifiers, unlike OTUs, they can be compared to any 16S rRNA or genomic data base now and in the future, thereby promoting reusability 22 . While earlier largescale 16S rRNA amplicon studies adopted OTU clustering approaches in part out of concern that erroneous reads would dominate... | [2.0, 4.0, 2.0, 2.0] | Biology | train | 2.5 | tweets | 926454748353564672 |
10.1038/s41467-018-04408-0 | Biology_tweet_297 | Lower Testosterone Levels May Be Linked to Greater Lupus Risk in Women, Study Finds | Further, a physiological testosterone replacement reduced spleen levels of Baff mRNA in castrated control but not G-ARKO mice (Fig. | Lower Testosterone Levels May Be Linked to Greater Lupus Risk in Women, Study Finds | Indeed, Tnfsf13b (Baff) mRNA in the spleen was increased in G-ARKO mice (Fig. Further, a physiological testosterone replacement reduced spleen levels of Baff mRNA in castrated control but not G-ARKO mice (Fig. 3e) ; thus, testosterone downregulates splenic Baff mRNA in an AR-dependent manner. | [1.0, 2.0, 1.0, 1.0] | Biology | train | 1.25 | tweets | 1009830063162974209 |
10.1038/s41467-017-01957-8 | Biology_tweet_299 | Again a fantastic study from those labs. Trade offs are dynamic and affect #Diversity in #coevolution systems. | Furthermore, coevolved ciliates had a significantly higher growth rate compared to the ancestral ciliates at a given coevolved bacteria population ( Fig. | Again a fantastic study from those labs. Trade offs are dynamic and affect #Diversity in #coevolution systems. | 1a , Kruskal-Wallis ancestral vs. coevolved bacteria: χ 2 = 6.2, df = 1, p = 0.005). Furthermore, coevolved ciliates had a significantly higher growth rate compared to the ancestral ciliates at a given coevolved bacteria population ( Fig. 1b-d , coevolved bacteria population 1: Kruskal-Wallis ancestral vs. coevolved ci... | [4.0, 3.0, 2.0, 3.0] | Biology | train | 3 | tweets | 940647297108664326 |
10.14814/phy2.13617 | Biology_tweet_3 | #Sleep #LightAtNight Sensitivity of the circadian system to evening bright light in preschool‐age children. | Findings from this study indicated that school-age children were almost twice as sensitive to the melatonin suppression effects of evening moderate bright light exposure (~580 lux) than their parents . | #Sleep #LightAtNight Sensitivity of the circadian system to evening bright light in preschool‐age children. | Findings from this study mark an important step in addressing a gap in understanding the melatonin suppression response across the lifespan. Findings from this study indicated that school-age children were almost twice as sensitive to the melatonin suppression effects of evening moderate bright light exposure (~580 lux... | [5.0, 3.0, 4.0, 3.0] | Biology | train | 3.75 | tweets | 992419683361067008 |
10.1038/s41467-018-04355-w | Biology_tweet_30 | Factor XIIIA-Expressing Inflammatory Monocytes Promote Lung Squamous Cancer through Fibrin Cross-Linking @username @username @username | Notably, we show that IMs highly express Factor XIIIA, which promotes fibrin cross-linking to create a scaffold for LUSC cell invasion and metastases. | Factor XIIIA-Expressing Inflammatory Monocytes Promote Lung Squamous Cancer through Fibrin Cross-Linking @username @username @username | Pharmacologic inhibition of IM recruitment had substantial anti-metastatic effects. Notably, we show that IMs highly express Factor XIIIA, which promotes fibrin cross-linking to create a scaffold for LUSC cell invasion and metastases. Consistently, human LUSC samples containing extensive crosslinked fibrin in the micro... | [4.0, 5.0, 2.0] | Biology | train | 4 | tweets | 1000506886788173824 |
10.1016/j.nutres.2019.03.004 | Biology_tweet_31 | #Study: #Walnut Consumption (2 Ounces/Day) May Afford #Breast #Cancer Protection via Altered #Gene Expression More: Attn: @username @username @username #food #health #nutrition #prevention | RNA sequencing expression profiling revealed that expression of 456 identified genes was significantly changed in the tumor due to walnut consumption. | #Study: #Walnut Consumption (2 Ounces/Day) May Afford #Breast #Cancer Protection via Altered #Gene Expression More: Attn: @username @username @username #food #health #nutrition #prevention | Pathological studies confirmed that lumps were breast cancer in all women who remained in the trial. RNA sequencing expression profiling revealed that expression of 456 identified genes was significantly changed in the tumor due to walnut consumption. Ingenuity Pathway Analysis showed activation of pathways that promot... | [4.0, 3.0, 3.0, 2.0, 5.0] | Biology | train | 3.4 | tweets | 1105538072635047936 |
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