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10.1186/s40168-015-0071-z | Biology_tweet_32 | Do breast milk glycans enrich beneficial bacteria in infant guts? @username finds a role for fucosyltransferase 2 | Specifically, secretor-fed infants generally had higher relative amounts of Bifidobacterium (p < 0.05) and Bacteroides and lower levels of enterobacteria, clostridia, and streptococci (p < 0.05). | Do breast milk glycans enrich beneficial bacteria in infant guts? @username finds a role for fucosyltransferase 2 | When grouped by the mothers' secretor status, differences were seen in the aggregated infants' gut microbiota ( Figure 2 ). Specifically, secretor-fed infants generally had higher relative amounts of Bifidobacterium (p < 0.05) and Bacteroides and lower levels of enterobacteria, clostridia, and streptococci (p < 0.05). ... | [4.0, 3.0, 2.0, 5.0, 2.0] | Biology | train | 3.2 | tweets | 586546592968224768 |
10.1098/rsos.171474 | Biology_tweet_33 | New #RegisteredReport published in #RSOS by @username at the @username and Netta Weinstein at @username explores the relationship between adolescents playing violent video games and their likelihood of behaving aggressively. Find out more at | The results provide confirmatory evidence that violent video game engagement, on balance, is not associated with observable variability in adolescents' aggressive behaviour. | New #RegisteredReport published in #RSOS by @username at the @username and Netta Weinstein at @username explores the relationship between adolescents playing violent video games and their likelihood of behaving aggressively. Find out more at | This is among the first studies to test the effects of violent gaming on human aggression using a preregistered hypothesis-testing framework and the first to do so following the registered reports protocol. The results provide confirmatory evidence that violent video game engagement, on balance, is not associated with ... | [4.0, 5.0, 4.0] | Biology | train | 4.333333 | tweets | 1095663919308382208 |
10.1038/s41396-017-0042-4 | Biology_tweet_34 | RT gp_pulipaka: Deposition Rates of 800 Million Airborne Viruses and Bacteria Above the Atmospheric Boundary Layer: Big Data Analysis. #BigData #DataScience #Analytics #HealthTech
| The daily deposition rates of viruses associated with aerosols <0.7 μm in size explains observations that identical viral sequences occur at geographically distant locations and in very different environments , likely as a consequence of long persistence and dispersal in the atmosphere. | RT gp_pulipaka: Deposition Rates of 800 Million Airborne Viruses and Bacteria Above the Atmospheric Boundary Layer: Big Data Analysis. #BigData #DataScience #Analytics #HealthTech
| Therefore, these relationships between the size fractions of the organic aerosols and the virus and bacteria deposition rates could be also determined by the origin of air masses. The daily deposition rates of viruses associated with aerosols <0.7 μm in size explains observations that identical viral sequences occur at... | [4.0, 3.0, 4.0, 3.0] | Biology | train | 3.5 | tweets | 987949298305380352 |
10.1186/s40168-015-0071-z | Biology_tweet_35 | Mum's genes influence bub's microbiota: Babies of mothers with FUT2 gene mutation have less gut Bifidobacteria | When grouped by the mothers' secretor status, differences were seen in the aggregated infants' gut microbiota ( Figure 2 ). | Mum's genes influence bub's microbiota: Babies of mothers with FUT2 gene mutation have less gut Bifidobacteria | Differences were seen between the five C-section-born infants and the 39 vaginally born infants, with C-section infants having much lower levels of bifidobacteria and Bacteroides, although the number of C-section infants was too low to draw any robust conclusions (Additional file 3: Figure S1 ). When grouped by the mot... | [4.0, 2.0, 4.0] | Biology | train | 3.333333 | tweets | 587800449857622018 |
10.1098/rstb.2017.0259 | Biology_tweet_36 | you might be surprised to learn about how American crows respond to dead conspecifics - interesting study (and blog post) by @username and @username | If crows exhibit a danger response, we expect higher rates of alarm calling and recruitment coupled with lower rates of contact in contrast to heterospecifics. | you might be surprised to learn about how American crows respond to dead conspecifics - interesting study (and blog post) by @username and @username | If such information acquisition motivates tactile interactions, we expect that interactions will be coupled with alarm calling and recruitment, be primarily non-aggressive in nature and occur frequently and uniformly across the study period. If crows exhibit a danger response, we expect higher rates of alarm calling an... | [1.0, 5.0, 2.0, 3.0] | Biology | train | 2 | tweets | 1018892879404634112 |
10.1098/rsbl.2013.0620 | Biology_tweet_37 | Dr. G. Mills of WildCRU et al. show how cheetah hunting tactics vary according to their prey via @username | Rather, we suggest that cheetah chases comprise two primary phases: (i) an initial rapid acceleration resulting in high speed to quickly catch up with prey, followed by (ii) a prey-specific slowing period that enables the cheetah to match turns instigated by prey as the distance between them closes. | Dr. G. Mills of WildCRU et al. show how cheetah hunting tactics vary according to their prey via @username | Thus, the widely held belief that cheetah hunts consist of simple highspeed chases seems an oversimplification. Rather, we suggest that cheetah chases comprise two primary phases: (i) an initial rapid acceleration resulting in high speed to quickly catch up with prey, followed by (ii) a prey-specific slowing period tha... | [4.0, 4.0, 4.0, 5.0] | Biology | train | 4.25 | tweets | 375312376490647552 |
10.3945/jn.113.188441 | Biology_tweet_38 | Beware the instant noodle! A marker of fast food dietary pattern in Korea,linked to obesity, high LDL &triglycerides | Participants who frequently consumed instant noodles ($2 times/wk) and those in the highest quintile of the MP were younger, more likely to be current smokers, drink more alcohol, be less physically active, and have low carbohydrate intake in both genders (Table 1) . | Beware the instant noodle! A marker of fast food dietary pattern in Korea,linked to obesity, high LDL &triglycerides | In addition, the mean sodium intake was very high across all categories (age-standardized mean sodium intake: 6.0 g in men, 4.2 g in women). Participants who frequently consumed instant noodles ($2 times/wk) and those in the highest quintile of the MP were younger, more likely to be current smokers, drink more alcohol,... | [2.0, 2.0, 2.0] | Biology | train | 2 | tweets | 491425485352476673 |
10.1038/nature12167 | Biology_tweet_39 | first ever class F GPCR structure: human SMO receptor with antagonist | However, an overlay of the SMO receptor structure with previously solved class A GPCR structures shows relatively high spatial conservation of the 7TM bundle (Fig. | first ever class F GPCR structure: human SMO receptor with antagonist | Sequence similarity between the SMO receptor and class A GPCRs is very low (less than 10% sequence identity), and SMO and other class F receptors lack most of the conserved class A motifs, including D[E]R 3.50 Y in helix III, CWXP .50 in helix V and NP 7.50 XXY in helix VII (superscript numbers reflect the B&W numberin... | [1.0, 3.0, 3.0, 2.0, 2.0] | Biology | train | 2.2 | tweets | 329682457811116032 |
10.1126/sciadv.aaq0883 | Biology_tweet_40 | Asylum seekers in Western Europe boost their host countries' economies over time, a new study in @username concludes: | We do not deny that large flows of asylum seekers into Europe pose many political challenges both within host countries and with respect to the European coordination of national policies. | Asylum seekers in Western Europe boost their host countries' economies over time, a new study in @username concludes: | Year 1 rather be an economic opportunity. We do not deny that large flows of asylum seekers into Europe pose many political challenges both within host countries and with respect to the European coordination of national policies. However, these political challenges may be more easily addressed if the cliché that intern... | [4.0, 2.0, 1.0, 2.0] | Biology | train | 2.25 | tweets | 1009501290098053120 |
10.1038/s41467-018-05664-w | Biology_tweet_43 | Stepping towards universal #QuantumComputing.
The universal holonomic gates enable fast and fault-tolerant manipulation for realising quantum repeaters interfacing between universal quantum computers and secure communication networks.
| We also demonstrate a two-qubit holonomic gate to show universality by manipulating the electron−nucleus entanglement. | Stepping towards universal #QuantumComputing.
The universal holonomic gates enable fast and fault-tolerant manipulation for realising quantum repeaters interfacing between universal quantum computers and secure communication networks.
| We also demonstrate a two-qubit holonomic gate to show universality by manipulating the electron−nucleus entanglement. The universal holonomic gates enable fast and fault-tolerant manipulation for realising quantum repeaters interfacing between universal quantum computers and secure communication networks. However, the... | [3.0, 5.0, 3.0, 3.0] | Biology | train | 3.5 | tweets | 1029120219912986624 |
10.1016/j.molcel.2014.05.030 | Biology_tweet_44 | RESEARCH: More light shed on #melanoma development #skincancer #sunscreen #tanning
-- | Though MC1R dysfunction is clearly linked with defective tanning , MC1R signaling also protects melanocytes against carcinogenesis independent of pigmentation . | RESEARCH: More light shed on #melanoma development #skincancer #sunscreen #tanning
-- | R151C, R160W and D294H) exhibit a fair-skinned sun-sensitive phenotype and have up to a four-fold increased lifetime risk of melanoma . Though MC1R dysfunction is clearly linked with defective tanning , MC1R signaling also protects melanocytes against carcinogenesis independent of pigmentation . ATR (ATM and Rad3-relat... | [4.0, 4.0, 3.0, 3.0] | Biology | train | 3.5 | tweets | 489055446037049344 |
10.1016/j.neuron.2014.04.039 | Biology_tweet_45 | β-Amyloid inhibits E-S potentiation through suppression of cannabin... - PubMed - NCBI | The present discovery of an explicit role for Ab in suppressing cannabinoid function elucidates a substrate of Alzheimer's pathology. | β-Amyloid inhibits E-S potentiation through suppression of cannabin... - PubMed - NCBI | The mechanism by which Ab disables the effects of cannabinoids on synaptic inhibition, and thus disrupts plasticity, may explain learning and memory deficits in AD that occur in otherwise healthy neural circuits prior to AD-related neuronal cell death. The present discovery of an explicit role for Ab in suppressing can... | [4.0, 4.0, 3.0, 2.0, 2.0] | Biology | train | 3 | tweets | 532250326435262464 |
10.1126/sciadv.aau1291 | Biology_tweet_46 | RT @username This makes much sense! why exposing the entire body every single day in a person that only has focal seizures from time to time? this local delivery of drug to the source of the seizure would be an excellent choice in #epilepsy (from @username) | The FIP probe can detect pathological activity and then intervene to stop seizures by delivering inhibitory neurotransmitters directly to the seizure source. | RT @username This makes much sense! why exposing the entire body every single day in a person that only has focal seizures from time to time? this local delivery of drug to the source of the seizure would be an excellent choice in #epilepsy (from @username) | The therapeutic potential of the FIP probe is tested in a rodent model of epilepsy. The FIP probe can detect pathological activity and then intervene to stop seizures by delivering inhibitory neurotransmitters directly to the seizure source. We anticipate that further tailored engineering of the FIP platform will en... | [3.0, 5.0, 3.0, 5.0, 2.0] | Biology | train | 3 | tweets | 1035088610830299137 |
10.1038/s41589-018-0155-8 | Biology_tweet_47 | EVIDENCE: Newly developed inhibitor of ADBH12, DO264 is shown to result in elevated lyso-PS levels in mice without loss of auditory function associated with ADBH12 knockout.
@username
#4bb3neuroimmune | We also found that DO264 inhibits ABHD12 activity ( Supplementary Fig. | EVIDENCE: Newly developed inhibitor of ADBH12, DO264 is shown to result in elevated lyso-PS levels in mice without loss of auditory function associated with ADBH12 knockout.
@username
#4bb3neuroimmune | ), which adopt a more macrophage-like cell state compared to undifferentiated THP-1 cells. We also found that DO264 inhibits ABHD12 activity ( Supplementary Fig. 16 ) and alters lyso-PS and PS content in primary human macrophages, which showed elevations in both lyso-PS and 20:4 PS following 4 or 24 h treatment with DO... | [3.0, 4.0, 2.0, 1.0, 3.0] | Biology | train | 2.6 | tweets | 1067703178148438021 |
10.1111/gcb.13526 | Biology_tweet_48 | Leaves suck? Yield boost in soybean seen by cutting leaves off. | The predicted gains in yield were primarily due to decreased investment in leaves allowing predicted increase in seed production. | Leaves suck? Yield boost in soybean seen by cutting leaves off. | The model therefore predicts that the additional two units of LAI above the model predicted optimum would not significantly contribute to net carbon gain, as photosynthesis roughly compensated for respiratory costs (Fig. The predicted gains in yield were primarily due to decreased investment in leaves allowing predicte... | [4.0, 4.0, 4.0, 4.0, 4.0] | Biology | train | 4 | tweets | 799736439458111488 |
10.1126/sciadv.1501675 | Biology_tweet_49 | Using #satellite #remotesensing to track and prevent loss of critical #tiger habitat. Via @username @username
| This suggests that if future habitat loss is prevented, the tiger recovery now underway in some range states will accelerate. | Using #satellite #remotesensing to track and prevent loss of critical #tiger habitat. Via @username @username
| Most encouraging was that loss was less than expected in the 51 tiger reserves that serve as source sites in the priority landscapes. This suggests that if future habitat loss is prevented, the tiger recovery now underway in some range states will accelerate. In these promising locales of enhanced protection, a doublin... | [2.0, 2.0, 5.0, 2.0, 4.0] | Biology | train | 2 | tweets | 715976728561192960 |
10.1016/j.cmet.2015.02.003 | Biology_tweet_5 | Cutaneous Na+ Storage Strengthens the Antimicrobial Barrier Function of the Skin: submitted by srepen [link]... | Large amounts of Na + are stored in the skin. | Cutaneous Na+ Storage Strengthens the Antimicrobial Barrier Function of the Skin: submitted by srepen [link]... | Na + metabolism may represent an unappreciated functional component of skin barrier formation. Large amounts of Na + are stored in the skin. This age-dependent Na + accumulation is associated with primary (essential) and secondary hypertension . | [5.0, 5.0, 4.0, 2.0] | Biology | train | 4 | tweets | 577605484863066112 |
10.1038/s41598-019-39601-8 | Biology_tweet_50 | new paper published today in @username from my undergraduate work with lab mates at @username & @username! we asked: how do functional traits (related to sex & species) mediate the effect of urbanization on wild bees? | Analyses show no qualitative differences with bumble bees removed: OSR still becomes less female-biased as urbanization increases (Table S3 ). | new paper published today in @username from my undergraduate work with lab mates at @username & @username! we asked: how do functional traits (related to sex & species) mediate the effect of urbanization on wild bees? | made up a large portion of our sample set; most bumble bee species are eusocial, and as such may experience controls on OSR that differ substantially from other bees (see Introduction). Analyses show no qualitative differences with bumble bees removed: OSR still becomes less female-biased as urbanization increases (Tab... | [3.0, 3.0, 3.0] | Biology | train | 3 | tweets | 1103310660925038592 |
10.1016/j.neuron.2013.09.021 | Biology_tweet_51 | RNAi in songbirds to study the involvment of FoxP2 in song variability in @username | Therefore, reducing FoxP2 levels in Area X abolishes context-dependent changes in both LMAN singing-related activity and song variability. | RNAi in songbirds to study the involvment of FoxP2 in song variability in @username | Finally, both the mean firing rates and levels of bursting activity of LMAN neurons recorded in the directed state were significantly higher in the LV-ShFoxP2 birds (Figures 6D and 6E ; p = 0.006 and p = 0.013, respectively). Therefore, reducing FoxP2 levels in Area X abolishes context-dependent changes in both LMAN si... | [3.0, 3.0, 3.0, 3.0, 4.0] | Biology | train | 3.2 | tweets | 408349111281131521 |
10.3945/jn.113.188441 | Biology_tweet_52 | Limit the Ramen: Instant noodles linked to heart risk in women
Abstract: | In our study, the association between instant noodles and metabolic syndrome differed significantly between genders, and there was no effect modification of this association by age, BMI, or physical activity. | Limit the Ramen: Instant noodles linked to heart risk in women
Abstract: | Even though measurements of the glycemic index of instant noodles varied among studies , the overall glycemic load of instant noodles is high, given their high carbohydrate content ( ( . In our study, the association between instant noodles and metabolic syndrome differed significantly between genders, and there was no... | [3.0, 3.0, 2.0, 4.0, 3.0] | Biology | train | 3 | tweets | 502439920238333952 |
10.1016/j.cub.2018.06.016 | Biology_tweet_54 | How does the brain control social interactions? @username et al. from @username show forebrain control of visually mediated social orienting in #zebrafish.
| We conclude from these results that another socially engaged fish is the stimulus required for social orienting and that the presence of another fish that is not socially engaged is insufficient regardless of their proximity. | How does the brain control social interactions? @username et al. from @username show forebrain control of visually mediated social orienting in #zebrafish.
| We placed apo-treated fish in a shortened tank that restricted their movement away from the divider and found that test fish exposed to apo-treated stimulus fish still had suppressed social orienting relative to controls (Figures 2A-2D ; p = 0.009, n = 26). We conclude from these results that another socially engaged ... | [3.0, 5.0, 2.0, 2.0, 3.0] | Biology | train | 3 | tweets | 1022743856125763585 |
10.1186/s40168-015-0071-z | Biology_tweet_55 | #humanmicrobiome David Mills- more bifidobacteria less glycans in baby's poop | Bifidobacteria were found to be established (High-Bif qPCR ) earlier in secretorfed infants (60% of infants versus 37.5% at day 6) and more often (80% versus 50% by day 120) ( Figure 5 ). | #humanmicrobiome David Mills- more bifidobacteria less glycans in baby's poop | Much of the bifidobacterial abundance difference between the two secretor status milk phenotypes appears to come from variation in the time at which each infant transitions from possessing a Low-Bif qPCR ' gut community to possessing a High-Bif qPCR gut community. Bifidobacteria were found to be established (High-Bif q... | [4.0, 1.0, 4.0, 3.0] | Biology | train | 4 | tweets | 616546067396579328 |
10.1093/jee/tou026 | Biology_tweet_56 | More evidence that the emerald ash borer attacks white fringetrees (Chionanthus virginicus ). White fringetrees... | Infestation of ash trees by emerald ash borer became visibly apparent for the first time in the village and nearby areas in 2012 (personal observation). | More evidence that the emerald ash borer attacks white fringetrees (Chionanthus virginicus ). White fringetrees... | White fringetree is in the same family as ash trees, and planted individuals and wild populations will come increasingly in contact with emerald ash borer as it spreads to the southeastern United States. Infestation of ash trees by emerald ash borer became visibly apparent for the first time in the village and nearby a... | [2.0, 2.0, 4.0] | Biology | train | 2.666667 | tweets | 555801187736621056 |
10.1016/j.bpj.2013.12.017 | Biology_tweet_59 | A BPJ paper finds that the appearance of #Lymedisease rash can help predict how bacteria spreads through body | Activation of the innate immune response is strongest at the center of the rash and clears most, but not all, of the bacteria from the center within~1 week. | A BPJ paper finds that the appearance of #Lymedisease rash can help predict how bacteria spreads through body | 2 g shows a radial slice through a simulated central erythema and shows how the spirochete and macrophage populations change as the rash progresses. Activation of the innate immune response is strongest at the center of the rash and clears most, but not all, of the bacteria from the center within~1 week. Therefore, the... | [2.0, 4.0, 2.0, 4.0] | Biology | train | 3 | tweets | 430754817363804161 |
10.1083/jcb.201710132 | Biology_tweet_6 | Messenger et al. show that exosome secretion in cancer cells is Ca2+-stimulated and dependent on Ca2+-bound Munc13-4. Munc13-4, a late endosome priming factor, acts via a Rab11-dependent pathway to prepare multivesicular endosomes for exocytosis | We propose that the increased expression of Munc13-4 in cancer cells after epithelial-to-mesenchymal transition combined with increased Ca 2+ uptake drives enhanced exosome release by highly aggressive cancer cells, and that Munc13-4 is a potential target for therapeutic intervention. | Messenger et al. show that exosome secretion in cancer cells is Ca2+-stimulated and dependent on Ca2+-bound Munc13-4. Munc13-4, a late endosome priming factor, acts via a Rab11-dependent pathway to prepare multivesicular endosomes for exocytosis | This Ca 2+ -, Munc13-4-, and Rab11dependent pathway generated secretion-competent MVBs for basal and Ca 2+ -stimulated CD63 + exosome release. We propose that the increased expression of Munc13-4 in cancer cells after epithelial-to-mesenchymal transition combined with increased Ca 2+ uptake drives enhanced exosome rele... | [4.0, 4.0, 4.0, 4.0] | Biology | train | 4 | tweets | 1012681596258934793 |
10.1038/ng.955 | Biology_tweet_60 | Discovery of a rare BRIP1 mutation (0.4% freq) that has >800% increase risk of ovarian cancer | Ovarian tumors from BRIP1 mutation carriers show loss of the wild-type allele, suggesting that the BRIP1 gene behaves like a classical tumor suppressor gene in ovarian cancer and that tumors with bi-allelic loss of BRIP1 may be good targets for therapeutic agents that affect DNA repair pathways. | Discovery of a rare BRIP1 mutation (0.4% freq) that has >800% increase risk of ovarian cancer | Furthermore, the lives of BRIP1 mutation carriers are on average 3.6 years shorter than those of non-carriers. Ovarian tumors from BRIP1 mutation carriers show loss of the wild-type allele, suggesting that the BRIP1 gene behaves like a classical tumor suppressor gene in ovarian cancer and that tumors with bi-allelic lo... | [2.0, 2.0, 4.0, 4.0] | Biology | train | 3 | tweets | 120644384592105473 |
10.1038/s41467-018-04408-0 | Biology_tweet_61 | Testosterone Is an Endogenous Regulator of BAFF & Splenic B Cell Number @username @username | Therefore, differences in the regulation of BAFF by estradiol and testosterone, potentially driven by nervous mechanisms, may contribute to the sex difference in autoimmune diseases in which BAFF has a pathogenic function. | Testosterone Is an Endogenous Regulator of BAFF & Splenic B Cell Number @username @username | Hence, estradiol elevates BAFF production and accelerates autoimmune disease , whereas testosterone has the opposite effects . Therefore, differences in the regulation of BAFF by estradiol and testosterone, potentially driven by nervous mechanisms, may contribute to the sex difference in autoimmune diseases in which BA... | [1.0, 3.0, 2.0, 3.0] | Biology | train | 2.25 | tweets | 1004493164055597058 |
10.1111/1365-2656.12871 | Biology_tweet_64 | Disease dynamics of viral biocontrol agents against invasive rabbits: myxoma virus (MYXV) may reduce the future survival rates of individuals that endure initial MYXV infection, paving the way for RHDV to more efficiently kill rabbits
| Relatively constant rates of RHDV-and MYXV-induced mortality and infection rates over time are likely to be the result of strongly coupled coevolutionary changes in host resistance and tolerance and pathogen invasiveness, each working to keep the other at bay. | Disease dynamics of viral biocontrol agents against invasive rabbits: myxoma virus (MYXV) may reduce the future survival rates of individuals that endure initial MYXV infection, paving the way for RHDV to more efficiently kill rabbits
| However, this is despite the viruses having devastating impacts on rabbit survival when the epidemics first occurred, likely because initial disease dynamics are often transient and differ from long-term outcomes ). Relatively constant rates of RHDV-and MYXV-induced mortality and infection rates over time are likely to... | [3.0, 3.0, 3.0, 4.0] | Biology | train | 3.25 | tweets | 1016951622461603840 |
10.1038/s41467-018-04373-8 | Biology_tweet_65 | Great job & Interesting results! Cytoplasmic SFPQ is in normal axon, where essential for motor function. So, on top of nuclear loss, perturbation of axonal function may contribute to ALS intron pathology. Watch that space! | The most significant intron-retaining transcript across VCP mu , SOD1 mu and FUS mu iPSC models was SFPQ, which encodes a protein that plays key roles in salient ALS-related pathways including RNA transcription, splicing, 3′ end processing and axon viability . | Great job & Interesting results! Cytoplasmic SFPQ is in normal axon, where essential for motor function. So, on top of nuclear loss, perturbation of axonal function may contribute to ALS intron pathology. Watch that space! | These findings together raise the hypothesis that aberrant IR represents subtle manifestations of a dysregulated pathway of the developing neurons, which eventually contributes to the increased vulnerability of mature MNs. The most significant intron-retaining transcript across VCP mu , SOD1 mu and FUS mu iPSC models w... | [2.0, 4.0, 3.0, 3.0] | Biology | train | 3 | tweets | 1000144648751460353 |
10.1038/ncomms4081 | Biology_tweet_66 | Synthetic self-propelled swimming bio-bots: (powered by cardiomyocytes) | The study thus provides a foundation for a new class of self-propelled, batch-fabricable, soft biological swimming machines. | Synthetic self-propelled swimming bio-bots: (powered by cardiomyocytes) | Although only cardiomyocytes are used as contractile cells in this work, the method is applicable to other homotypic cell types, such as optogenetic muscle cells for light-actuated swimming, or heterotypic cells types, such as turtle cardiomyocytes and fibroblasts for room temperature swimming, and neurons and muscle c... | [4.0, 4.0, 5.0, 5.0] | Biology | train | 4.5 | tweets | 425687584958726144 |
10.1373/clinchem.2012.187617 | Biology_tweet_67 | The gut #microbiome and #metabolism: implications for #obesity, #diabetes #HMP #DNA #nutrition | These human studies confirmed animal data suggesting that alterations in gut microbial composition are associated with obesity. | The gut #microbiome and #metabolism: implications for #obesity, #diabetes #HMP #DNA #nutrition | After weight loss, increased amounts of Bacteroidetes (3% to 15%) and a decreased abundance of Firmicutes were observed, and these changes correlated with the percentage of weight loss and not with changes in dietary caloric content. These human studies confirmed animal data suggesting that alterations in gut microbial... | [5.0, 3.0, 4.0] | Biology | train | 4 | tweets | 336505689545515008 |
10.1016/j.celrep.2014.05.030 | Biology_tweet_68 | NUCKS levels inversely correlate with obesity in humans and mice | Together, these results, especially the finding that nutrient overload exacerbates the metabolic phenotypes in the absence of NUCKS, suggest that NUCKS plays a role in metabolic homeostasis in vivo. | NUCKS levels inversely correlate with obesity in humans and mice | Consistent with the obese phenotype, leptin levels were elevated while those of adiponectin were decreased in HFD-fed NUCKS KO mice ( Figure S3G and S3H) . Together, these results, especially the finding that nutrient overload exacerbates the metabolic phenotypes in the absence of NUCKS, suggest that NUCKS plays a role... | [3.0, 4.0, 4.0] | Biology | train | 3.666667 | tweets | 484952704184115200 |
10.1002/stem.2883 | Biology_tweet_7 | Human induced pluripotent stem cells generate light responsive retinal organoids with variable and nutrient dependent efficiency. | Together our data indicate that light responsive retinal organoids derived from carefully selected and differentiation efficient iPSC lines can be generated at the scale needed for pharmacology and drug screening purposes. | Human induced pluripotent stem cells generate light responsive retinal organoids with variable and nutrient dependent efficiency. | We tested the response of iPSC-derived retinal organoids to Moxifloxacin and showed that similarly to in vivo adult mouse retina, the primary affected cell types were photoreceptors. Together our data indicate that light responsive retinal organoids derived from carefully selected and differentiation efficient iPSC lin... | [3.0, 1.0, 3.0, 4.0] | Biology | train | 2.75 | tweets | 1018079131395751936 |
10.1038/s41467-018-06087-3 | Biology_tweet_70 | New from colleagues at BristolChem "Antagonistic chemical coupling in self-reconfigurable host-guest protocells." #chemistry #bristol | Self-reconfiguration of host-guest protocells containing spatially separated GOx and HRP produced multi-enzyme vesicle-inproteinosome nested microstructures. | New from colleagues at BristolChem "Antagonistic chemical coupling in self-reconfigurable host-guest protocells." #chemistry #bristol | For example, internalisation of the fatty acid vesicles within the proteinosomes resulted in a 1.7 to 2.6-fold accumulation of positively charged, low-molecular weight solutes (RITC-HRP, αdansyl-L-arginine or RITC-labelled Mb) compared with the external continuous phase (Fig. Self-reconfiguration of host-guest protocel... | [2.0, 3.0, 2.0, 3.0] | Biology | train | 2.5 | tweets | 1038729276168777728 |
10.1098/rsos.180695 | Biology_tweet_72 | When we go home, we like to make an indoor climate like our ancestral home in Eastern Africa
New study in Royal Society Open Science
Inside Science story
Read more on climate adaptations in my book | Overall, we identified the geographical distribution of the global outdoor climate that is most similar to the interiors of our study homes and summarized study home indoor climate preferences. | When we go home, we like to make an indoor climate like our ancestral home in Eastern Africa
New study in Royal Society Open Science
Inside Science story
Read more on climate adaptations in my book | We found that the indoor climates of our study homes largely matched the TNZ of humans and other primates. Overall, we identified the geographical distribution of the global outdoor climate that is most similar to the interiors of our study homes and summarized study home indoor climate preferences. It would be difficu... | [3.0, 4.0, 4.0, 2.0, 2.0] | Biology | train | 3 | tweets | 1108345524942331904 |
10.1073/pnas.1504869112 | Biology_tweet_73 | Vines (lianas) reduce carbon storage in tropical forests. New paper from @username | The increase in lianas, combined with the observations that lianas can reduce individual tree growth by up to 84% and increase tree mortality risk two-to three-fold , has made it pertinent to investigate the effect of lianas on forest-level biomass dynamics to better predict the effect of increasing liana abundance on ... | Vines (lianas) reduce carbon storage in tropical forests. New paper from @username | Liana-tree competition can be far more intense than tree-tree competition (3), substantially reducing tree growth , fecundity , and survival . The increase in lianas, combined with the observations that lianas can reduce individual tree growth by up to 84% and increase tree mortality risk two-to three-fold , has made i... | [4.0, 3.0, 3.0, 3.0, 2.0] | Biology | train | 3 | tweets | 654294456770932736 |
10.1098/rsos.171474 | Biology_tweet_74 | The best available evidence: "We argue that this study speaks to the key question of whether adolescents’ violent video game play has a measurable effect on real-world aggressive behaviour On the basis of our evidence, the answer is no." | There was no evidence for a critical tipping point relating violent game engagement to aggressive behaviour. | The best available evidence: "We argue that this study speaks to the key question of whether adolescents’ violent video game play has a measurable effect on real-world aggressive behaviour On the basis of our evidence, the answer is no." | Results did not support this prediction, nor did they support the idea that the relationship between these factors follows a nonlinear parabolic function. There was no evidence for a critical tipping point relating violent game engagement to aggressive behaviour. Sensitivity and exploratory analyses indicated these nul... | [3.0, 5.0, 5.0, 5.0, 4.0] | Biology | train | 4.4 | tweets | 1095725862748651521 |
10.3945/jn.113.188441 | Biology_tweet_75 | Instant noodle intake and dietary patterns are associ... [J Nutr. 2014] - PubMed - NCBI | Dietary pattern and cardiometabolic risk factors 1249 adjustment by instant noodle intake attenuated the overall association between MP and abdominal obesity; however, the association between MP and abdominal obesity in men and the overall associations among MP and LDL cholesterol, HDL cholesterol, and hypertriglycerid... | Instant noodle intake and dietary patterns are associ... [J Nutr. 2014] - PubMed - NCBI | Interestingly, there was a lower prevalence of low HDL cholesterol (OR: 0.; 9% CI: 0., 0.80) and TGs $10 mg/dL (1. g/L) (OR: 0.; 9% CI: 0., 0.9) in the highest MP quintile. Dietary pattern and cardiometabolic risk factors 1249 adjustment by instant noodle intake attenuated the overall association between MP and abdomin... | [2.0, 2.0, 2.0, 3.0] | Biology | train | 2.25 | tweets | 520940730765025281 |
10.1073/pnas.1504869112 | Biology_tweet_76 | really interesting finding that lianas reduce total ecosystem #carbon uptake and storage in tropical #forests | Likewise, a potential liana-driven shift in tree species composition may also alter long-term biomass carbon storage if the presence of lianas leads to an increase in fast-growing trees with low wood densities, as is predicted . | really interesting finding that lianas reduce total ecosystem #carbon uptake and storage in tropical #forests | Long-term Submission PDF biomass carbon storage may be further reduced if increasing liana biomass intensifies liana-tree competition and/or increases the proportion of trees that are competing with lianas. Likewise, a potential liana-driven shift in tree species composition may also alter long-term biomass carbon stor... | [5.0, 3.0, 2.0] | Biology | train | 3 | tweets | 656251720243154944 |
10.3945/jn.113.188441 | Biology_tweet_77 | What's a college student to do? Instant noodle intake associated with cardiometabolic risk factors. | The consumption of instant noodles $2 times/wk was associated with a higher prevalence of metabolic syndrome in women [OR: 1.68; 95% CI: 1.10, 2.55; P-trend < 0.01, P-interaction (gender 3 instant noodle intake) = 0.04] and marginally higher abdominal obesity in women (OR: 1.48; 95% CI: 0.99, 2.21; Ptrend = 0.06) but n... | What's a college student to do? Instant noodle intake associated with cardiometabolic risk factors. | The exclusion of participants taking blood pressurelowering or lipid-lowering medications or who had a history of diabetes mellitus did not change the overall associations between dietary patterns and cardiometabolic risk factors. The consumption of instant noodles $2 times/wk was associated with a higher prevalence of... | [4.0, 2.0, 4.0, 4.0] | Biology | train | 3.5 | tweets | 486612022608789505 |
10.1186/s40168-015-0071-z | Biology_tweet_78 | Maternal fucosyltransferase 2 status affects the gut bifidobacterial communities… #microbiome | Much of the bifidobacterial abundance difference between the two secretor status milk phenotypes appears to come from variation in the time at which each infant transitions from possessing a Low-Bif qPCR ' gut community to possessing a High-Bif qPCR gut community. | Maternal fucosyltransferase 2 status affects the gut bifidobacterial communities… #microbiome | The distribution of the qPCR data was bimodal, with a large group of samples with low levels of bifidobacteria (<10 7.6 /g feces, average 10 6.1 ) and a separate group with high amounts of bifidobacteria (>10 8.9 /g feces, average 10 10.3 ), with a striking lack of values falling in between the two ranges ( Figure 4 ).... | [2.0, 4.0, 2.0, 2.0, 2.0] | Biology | train | 2.4 | tweets | 593723617617149952 |
10.1111/gcb.13276 | Biology_tweet_8 | New tool to standardize and compare susceptibility of corals to thermal bleaching | Coral colonies, inhabiting the same reef and apparently exposed to identical conditions, will bleach and die at different rates Obura, 2001; . | New tool to standardize and compare susceptibility of corals to thermal bleaching | Within a bleaching event, coral susceptibility to stress is highly uneven. Coral colonies, inhabiting the same reef and apparently exposed to identical conditions, will bleach and die at different rates Obura, 2001; . Knowing which of many potential factors determine differential bleaching susceptibility among taxa wil... | [2.0, 1.0, 4.0, 4.0] | Biology | train | 2 | tweets | 720549155148537860 |
10.1016/j.cell.2018.05.009 | Biology_tweet_80 | Very cool work on pH dependent regulation of intracellular circadian rhythms. Pls don’t drink HCl to prevent cancer. | Buffering against acidification or inhibiting lactic acid production fully rescues circadian oscillation. | Very cool work on pH dependent regulation of intracellular circadian rhythms. Pls don’t drink HCl to prevent cancer. | Unexpectedly, we uncover a profound disruption of the circadian clock and diurnal transcriptome when hypoxic cells are permitted to acidify to recapitulate the tumor microenvironment. Buffering against acidification or inhibiting lactic acid production fully rescues circadian oscillation. We find that acid drives perip... | [2.0, 1.0, 2.0] | Biology | train | 1.666667 | tweets | 1002335662517948418 |
10.1016/j.cell.2018.04.038 | Biology_tweet_81 | Wow ! Another beautiful structure of telomerase. Recently there was a structure of human telomerase | All telomerases contain a catalytic core of TERT and TER, which are sufficient to reconstitute activity in vitro. | Wow ! Another beautiful structure of telomerase. Recently there was a structure of human telomerase | The cryo-EM structure of active Tetrahymena telomerase bound to telomeric DNA reveals unique insights into the catalytic core and DNA handling. All telomerases contain a catalytic core of TERT and TER, which are sufficient to reconstitute activity in vitro. The other seven proteins, p50, and two heterotrimeric replicat... | [5.0, 3.0, 4.0, 2.0, 2.0] | Biology | train | 3.2 | tweets | 997209602478563329 |
10.1038/nn.3728 | Biology_tweet_82 | Extinguishing fear: Active, phosphorylated FTY720 inhibits histone deacetylases & facilitates fear extinction memory | Altogether, these data indicate that FTY720 protected the SCID mice from deficits in expression of extinction in the contextual fear model. | Extinguishing fear: Active, phosphorylated FTY720 inhibits histone deacetylases & facilitates fear extinction memory | 7d-f) , nor tonedependent fear conditioning that is hippocampus independent, nor did it affect extinction of response to the tone conditioned stimulus (Supplementary Fig. Altogether, these data indicate that FTY720 protected the SCID mice from deficits in expression of extinction in the contextual fear model. This aspe... | [2.0, 5.0, 3.0, 4.0, 4.0] | Biology | train | 3.6 | tweets | 473715029712576512 |
10.1093/molbev/msv031 | Biology_tweet_83 | Schizophrenia-associated loci enrich in genes near Human Accelerated Regions (HARs)
| Because the HAR-associated genes are enriched in neurodevelopmental processes and results below), one may argue that the enrichment we observed when using all the human genes as background might simply indicate that both schizophrenia genes and pHAR genes are brain related. | Schizophrenia-associated loci enrich in genes near Human Accelerated Regions (HARs)
| In addition, pHARs may not be conserved in nonprimate mammals or may be different between primates and other mammals. Because the HAR-associated genes are enriched in neurodevelopmental processes and results below), one may argue that the enrichment we observed when using all the human genes as background might simply ... | [4.0, 3.0, 2.0] | Biology | train | 3 | tweets | 569696064900628480 |
10.1016/j.cell.2018.07.032 | Biology_tweet_86 | #Enterobactin, a #siderophore produced by E. coli and other bacteria, increases mitochondrial iron uptake in hosts, including humans. Fe(III)-Ent binds to the α subunit of the host mitochondrial ATP synthase. Enterobactin promoted growth in C. elegans.
| Given the symbiotic relationship between commensal E. coli and the host, one may speculate that an unknown beneficial mechanism has evolved in animals to use bacterial Ent for host iron homeostasis. | #Enterobactin, a #siderophore produced by E. coli and other bacteria, increases mitochondrial iron uptake in hosts, including humans. Fe(III)-Ent binds to the α subunit of the host mitochondrial ATP synthase. Enterobactin promoted growth in C. elegans.
| More importantly, this mechanism does not explain how host animals would cope with abundant Ent from non-infectious gut microbiota, of which enterobacteria are the most prevalent commensal microbes in both human and C. elegans . Given the symbiotic relationship between commensal E. coli and the host, one may speculate ... | [2.0, 4.0, 1.0, 3.0] | Biology | train | 2.5 | tweets | 1032645759340933120 |
10.1038/s41564-018-0276-6 | Biology_tweet_87 | Sorensen et al.: #Metagenomic analysis finds that higher soil temperatures are associated with smaller prokaryotic cell & genome sizes: | These results add evidence that supports selection for both smaller genomes and cells at higher temperatures, but also offer a key point of distinction. | Sorensen et al.: #Metagenomic analysis finds that higher soil temperatures are associated with smaller prokaryotic cell & genome sizes: | Surprisingly, it also suggests that microbial populations inhabiting complex environments, such as soils, may generally reflect similar overarching traits in genome size to those observed in laboratory studies. These results add evidence that supports selection for both smaller genomes and cells at higher temperatures,... | [4.0, 3.0, 1.0, 3.0, 5.0] | Biology | train | 3 | tweets | 1059488344315437057 |
10.1098/rspb.2018.0761 | Biology_tweet_88 | Interesting study on effects of #neonicotinoid exposure & pollen diet on #bumblebee queen nest initiation in @username Restricted diet impacts on queen & colony overshadowed by insecticide exposure, but monofloral pollen diet reduced brood numbers | Here, we demonstrate that sublethal exposure to imidacloprid, a widely used neonicotinoid-type insecticide, has a broad suite of negative effects on early-nesting bumblebee queens. | Interesting study on effects of #neonicotinoid exposure & pollen diet on #bumblebee queen nest initiation in @username Restricted diet impacts on queen & colony overshadowed by insecticide exposure, but monofloral pollen diet reduced brood numbers | Pollen diet was not an important driver of brood production overall, but among untreated queens, those fed monofloral Cistus pollen had significantly fewer larvae and pupae than queens fed mixed-source or monofloral Erica pollen ( p , 0.03 for counts of larvae and pupae). Here, we demonstrate that sublethal exposure to... | [3.0, 5.0, 2.0, 5.0] | Biology | train | 4 | tweets | 1006917387348668418 |
10.1038/s41467-019-09786-7 | Biology_tweet_89 | Epigenetic activation of the enhancer at IGF2 may enhance dopamine synthesis associated with major psychosis @username | In the striatum, inactivation of the Igf2 enhancer led to a decrease in TH protein levels and in dopamine (p < 0.05; one-way ANOVA; Fig. | Epigenetic activation of the enhancer at IGF2 may enhance dopamine synthesis associated with major psychosis @username | 7c ), supporting dysregulation of the TH-IGF2 locus in major psychosis. In the striatum, inactivation of the Igf2 enhancer led to a decrease in TH protein levels and in dopamine (p < 0.05; one-way ANOVA; Fig. 3d , e); this effect was not observed in the frontal cortex ( Supplementary Fig. | [2.0, 3.0, 4.0, 4.0, 1.0] | Biology | train | 2.8 | tweets | 1124255929543868418 |
10.1038/s41396-017-0042-4 | Biology_tweet_9 | It's raining #viruses: "each day some 800 million viruses cascade onto every square meter of the planet", study published at the @username says. Also, viral deposition rates were 9 to 461 times greater than for #bacteria | These deposition rates were 9-461 times greater than the rates for bacteria, which ranged from 0.3 × 10 7 to >8 × 10 7 m −2 per day. | It's raining #viruses: "each day some 800 million viruses cascade onto every square meter of the planet", study published at the @username says. Also, viral deposition rates were 9 to 461 times greater than for #bacteria | Here, we demonstrate that even in pristine environments, above the atmospheric boundary layer, the downward flux of viruses ranged from 0.26 × 10 9 to >7 × 10 9 m −2 per day. These deposition rates were 9-461 times greater than the rates for bacteria, which ranged from 0.3 × 10 7 to >8 × 10 7 m −2 per day. The highest ... | [5.0, 4.0, 2.0, 4.0] | Biology | train | 3.75 | tweets | 985210774120534016 |
10.1126/scitranslmed.aan1230 | Biology_tweet_90 | [Research Articles] TGF{beta} inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence | In the mouse, this relationship was reversed upon inhibition of TGFR1, restoring a proportional regenerative response to liver injury, mimicking genetic deletion of p21. | [Research Articles] TGF{beta} inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence | Therefore, severe liver injury in the mouse recapitulates the negative correlation between injury and regeneration observed in severe human disease (Fig. In the mouse, this relationship was reversed upon inhibition of TGFR1, restoring a proportional regenerative response to liver injury, mimicking genetic deletion of ... | [3.0, 4.0, 2.0, 3.0, 4.0] | Biology | train | 3.2 | tweets | 1029792735497048064 |
10.1016/j.cell.2018.06.012 | Biology_tweet_92 | Two action pathways in the brain: the "direct' pathway controls individual elements in a sequence of actions, the "indirect" pathway controls whole subsquences - leading to hierarchical control of behavior | Importantly, the basal ganglia direct and indirect pathways interact distinctly with these different controllers. | Two action pathways in the brain: the "direct' pathway controls individual elements in a sequence of actions, the "indirect" pathway controls whole subsquences - leading to hierarchical control of behavior | Together, these data suggest that the learned action sequence is likely organized in a hierarchical manner, with both local subsequence-level and global sequence-level controls. Importantly, the basal ganglia direct and indirect pathways interact distinctly with these different controllers. Similar to the observations ... | [4.0, 3.0, 2.0, 3.0, 4.0] | Biology | train | 3.2 | tweets | 1012350063648133122 |
10.1111/j.1600-0706.2013.00620.x | Biology_tweet_93 | MT @username: Climate change and annual survival in a temperate passerine (Long-tailed Tit) (Oikos) | Using our model to estimate historical survival rates indicates that recent spring warming has led to an upward trend in survival rates, which has probably contributed to the observed long-term increase in the UK long-tailed tit population. | MT @username: Climate change and annual survival in a temperate passerine (Long-tailed Tit) (Oikos) | There is little evidence for density dependence across the observed variation in population size. Using our model to estimate historical survival rates indicates that recent spring warming has led to an upward trend in survival rates, which has probably contributed to the observed long-term increase in the UK long-tail... | [2.0, 4.0, 5.0, 4.0] | Biology | train | 3.75 | tweets | 446578033693319168 |
10.1073/pnas.1619294114 | Biology_tweet_94 | #Cbf { #beta } governs osteoblast-adipocyte #lineage #commitment through enhancing { #beta } #-catenin signaling an.. | Wnt/ β-catenin directs mesenchymal cell commitment to the osteogenic lineage and prevents adipogenic differentiation, resulting in increased new bone formation . | #Cbf { #beta } governs osteoblast-adipocyte #lineage #commitment through enhancing { #beta } #-catenin signaling an.. | Runx/Cbfβ Complex Promotes Wnt10b/β-Catenin Signaling and Inhibits c/ebpa Expression to Inhibit Lineage Switch into Adipocytes. Wnt/ β-catenin directs mesenchymal cell commitment to the osteogenic lineage and prevents adipogenic differentiation, resulting in increased new bone formation . Interestingly, Wnt10b is downr... | [3.0, 2.0, 4.0] | Biology | train | 3 | tweets | 907835255360548864 |
10.1139/cjz-2017-0071 | Biology_easy_0 | "Very little is preventing their continued dispersal northward, provided they can survive winters," Walsh says. | 2010) , suggest that very little is preventing their continued dispersal northward, provided they can survive winters. | "It was so exciting because it was further confirmation that this range expansion is still happening and that these animals are probably going to keep moving even further northward as the climate warms and as humans continue to alter the landscape with more agriculture and urbanization," Walsh says. "Very little is pre... | A lack of substantial landscape barriers for opossums , coupled with their nomadic behavior, illustrated by fathers and offspring discovered up to 33 km apart Beasley et al. 2010) , suggest that very little is preventing their continued dispersal northward, provided they can survive winters. Opossums collared with GPS ... | [5] | Biology | train | 5 | news | http://www.futurity.org/virginia-opossum-range-1684512/ |
10.1139/cjz-2017-0071 | Biology_easy_1 | Walsh and Tucker found that measurements of genetic diversity across 15 counties were best explained by days of snow on the ground. | Using general linear models, we found that measurements of genetic diversity across fifteen counties are best explained by days of snow on the ground. | "More direct anthropogenic factors may also be important, including resources easily available in agricultural and suburban landscapes." Walsh and Tucker found that measurements of genetic diversity across 15 counties were best explained by days of snow on the ground. Farm density was also found to be an important fact... | Two genetic clusters were identified: one on either side of Lake Michigan. Using general linear models, we found that measurements of genetic diversity across fifteen counties are best explained by days of snow on the ground. These models suggest opossum expansion may be facilitated by agricultural land development and... | [5] | Biology | train | 5 | news | http://www.futurity.org/virginia-opossum-range-1684512/ |
10.1038/s41467-018-07557-4 | Biology_easy_4 | "This is the first study to explicitly show the amount of fundamental infrastructure potentially at risk across the Northern Hemisphere permafrost area under climate change," Hjort and his colleagues wrote in the paper. | In conclusion, this is the first study to explicitly show the amount of fundamental infrastructure potentially at risk across the Northern Hemisphere permafrost area under climate change. | The team found that 3.6 million people--three quarters of the current population in the Northern Hemisphere permafrost area--may be affected by infrastructure damage from permafrost thaw. "This is the first study to explicitly show the amount of fundamental infrastructure potentially at risk across the Northern Hemisph... | Our study can be considered to be a step forward toward these goals. In conclusion, this is the first study to explicitly show the amount of fundamental infrastructure potentially at risk across the Northern Hemisphere permafrost area under climate change. A total of 69% of the pan-Arctic residential, transportation, a... | [5] | Biology | train | 5 | news | http://ct.moreover.com/?a=37952323296&p=1pl&v=1&x=YZkcSHKHdqhjfYYiUvZ_gw |
10.1038/s41467-018-07557-4 | Biology_easy_6 | Alarmingly, these figures are not reduced substantially even if the climate change targets of the Paris Agreement are reached." | Alarmingly, these figures are not reduced substantially even if the climate change targets of the Paris Agreement are reached. | "Our results demonstrate that one-third of pan-Arctic infrastructure and 45 percent of the hydrocarbon extraction fields in the Russian Arctic are in regions where thaw-related ground instability can cause severe damage to the built environment. Alarmingly, these figures are not reduced substantially even if the climat... | Our results demonstrate that one-third of pan-Arctic infrastructure and 45% of the hydrocarbon extraction fields in the Russian Arctic are in regions where thaw-related ground instability can cause severe damage to the built environment. Alarmingly, these figures are not reduced substantially even if the climate change... | [5] | Biology | train | 5 | news | http://ct.moreover.com/?a=37952048427&p=1pl&v=1&x=WVBbJHZ_CDGkehwcKPFvdQ |
10.1038/s41467-018-04906-1 | Biology_easy_9 | "These sensors exhibited excellent optoelectronic properties and outstanding reliability against mechanical bending. | These sensors exhibited excellent optoelectronic properties and outstanding reliability against mechanical bending. | If the user's temperature isn't within the required limits, the fingerprint authentication might not push through. "These sensors exhibited excellent optoelectronic properties and outstanding reliability against mechanical bending. This fingerprint sensor array has a high resolution with good transparency," the researc... | These sensors exhibited excellent optoelectronic properties and outstanding reliability against mechanical bending. This fingerprint sensor array has a high resolution with good transparency. This sensor offers a capacitance variation~17 times better than the variation for the same sensor pattern using conventional ITO... | [5] | Biology | train | 5 | news | http://ct.moreover.com/?a=34467889819&p=1pl&v=1&x=bwlU4e1aRXgMmGqDDaSdMA |
10.1038/s41598-017-11843-4 | Biology_easy_12 | Priority for new drug-development to efficiently treat TB must be focused on the discovery of novel therapeutic targets and approaches. | A priority for new drug-development to efficiently treat TB must be focused on the discovery of novel therapeutic targets and approaches. | There is a new drug discovery that this study reported that said there is on track to generate new lead compounds along with their corresponding targets represent treat or need in the fight against TB. Priority for new drug-development to efficiently treat TB must be focused on the discovery of novel therapeutic target... | Above all, this work led to the identification of very promising anti-TB candidates that should be able to act against bacteria in various physiological stages, thus allowing a faster sterilization. A priority for new drug-development to efficiently treat TB must be focused on the discovery of novel therapeutic targets... | [5] | Biology | train | 5 | news | http://ct.moreover.com/?a=34850312293&p=1pl&v=1&x=Wz884h4s3tkDJfsmxreyRQ |
10.1038/s41467-018-07557-4 | Biology_easy_14 | "We show that nearly four million people and 70 percent of current infrastructure in the permafrost domain are in areas with high potential for thaw of near-surface permafrost," the team wrote. | We show that nearly four million people and 70% of current infrastructure in the permafrost domain are in areas with high potential for thaw of near-surface permafrost. | Findings showed that the thawing permafrost will pose a significant threat to Arctic communities across the Northern Hemisphere by 2050. "We show that nearly four million people and 70 percent of current infrastructure in the permafrost domain are in areas with high potential for thaw of near-surface permafrost," the t... | We show that nearly four million people and 70% of current infrastructure in the permafrost domain are in areas with high potential for thaw of near-surface permafrost. Our results demonstrate that one-third of pan-Arctic infrastructure and 45% of the hydrocarbon extraction fields in the Russian Arctic are in regions w... | [5] | Biology | train | 5 | news | http://ct.moreover.com/?a=37952048427&p=1pl&v=1&x=WVBbJHZ_CDGkehwcKPFvdQ |
10.1016/j.neuron.2017.06.028 | Biology_easy_16 | We think that the identification of the relevant molecular mediators of this form of plasticity may offer novel therapeutic strategies to recover from deficits in perception, learning and memory associated with a range of diseases.' | Hence, the identification of the relevant molecular mediators of this form of plasticity may offer novel therapeutic strategies to recover from deficits in perception, learning, and memory associated with a repertoire of diseases. | These novel findings show that Brevican is dynamically regulated by experiences coming from the environment and is fundamentally required for spatial working memory and short-term memories. When we identified some of the mechanisms underlying this regulation, I was amazed by how a single protein can act as an activity ... | By simultaneously regulating the excitatory inputs and firing properties of PV+ cells, a perineuronal net protein drives PV+ interneuron wiring as well as network adaptation to experience. Hence, the identification of the relevant molecular mediators of this form of plasticity may offer novel therapeutic strategies to ... | [5] | Biology | train | 5 | news | http://healthmedicinet.com/news/how-neurons-sense-our-everyday-life/ |
10.1186/s13578-015-0003-4 | Biology_easy_19 | LY294002 (a PI3K inhibitor) abolished but N-acetyl-cysteine (NAC, an inhibitor of reactive oxygen species, ROS) further enhanced the protective role of H2S against I/R induced myocardial damage in the aging hearts. | LY294002 (a PI3K inhibitor) abolished but N-acetyl-cysteine (NAC, an inhibitor of reactive oxygen species, ROS) further enhanced the protective role of H 2 S against I/R induced myocardial damage in the aging hearts. | Supply of NaHS not only increased PC-induced cardioprotection in the young hearts, but also lightened I/R induced-myocardial damage and significantly recovered the cardioprotective role of PC against I/R induced myocardial damage in the aging hearts. LY294002 (a PI3K inhibitor) abolished but N-acetyl-cysteine (NAC, an ... | Supply of NaHS not only increased PC-induced cardioprotection in the young hearts, but also lightened I/R induced-myocardial damage and significantly recovered the cardioprotective role of PC against I/R induced myocardial damage in the aging hearts. LY294002 (a PI3K inhibitor) abolished but N-acetyl-cysteine (NAC, an ... | [5] | Biology | train | 5 | news | http://www.technology.org/2015/03/22/a-novel-target-for-the-treatment-of-aging-cardiovascular-diseases/ |
10.1038/s41467-018-08278-4 | Biology_easy_22 | "These findings provide further support for the view that cells of a non-regenerative mammalian amputation wound retain the positional information necessary to re-build structures removed by amputation," conclude the researchers. | These findings provide further support for the view that cells of a non-regenerative mammalian amputation wound retain the positional information necessary to re-build structures removed by amputation, and that regenerative failure results from a deficiency of the wound environment that can be extrinsically manipulated... | It's a fascinating area of science, and we're learning a lot from lab-grown organs about how the process might be triggered more naturally. If we are eventually to develop treatments to replace lost limbs, the BMP2 and BMP9 proteins may well have something to do with it. "These findings provide further support for the ... | In the case of BMP9 treatment, a coordinated response involving condensation and differentiation of chondrocytes coupled with the formation of a synovial cavity results in the regeneration of joint structures. These two regenerative responses identify discrete morphogenetic programs that can be activated either indepen... | [5] | Biology | train | 5 | news | http://ct.moreover.com/?a=38466420113&p=1pl&v=1&x=IqxylWeo6-sJ6dtu0xtBJQ |
10.1038/s41467-018-04906-1 | Biology_easy_24 | This fingerprint sensor array has a high resolution with good transparency," the researchers said. | This fingerprint sensor array has a high resolution with good transparency. | "These sensors exhibited excellent optoelectronic properties and outstanding reliability against mechanical bending. This fingerprint sensor array has a high resolution with good transparency," the researchers said. "Furthermore, this fingerprint sensor array can be integrated with all transparent forms of tactile pres... | These sensors exhibited excellent optoelectronic properties and outstanding reliability against mechanical bending. This fingerprint sensor array has a high resolution with good transparency. This sensor offers a capacitance variation~17 times better than the variation for the same sensor pattern using conventional ITO... | [5] | Biology | train | 5 | news | http://ct.moreover.com/?a=34467889819&p=1pl&v=1&x=bwlU4e1aRXgMmGqDDaSdMA |
10.1139/cjz-2017-0071 | Biology_easy_28 | "These models suggest opossum expansion may be facilitated by agricultural land development and at the same time may be limited by their inability to forage in snow," Walsh writes. | These models suggest opossum expansion may be facilitated by agricultural land development and at the same time be limited by their inability to forage in snow. | Farm density was also found to be an important factor. "These models suggest opossum expansion may be facilitated by agricultural land development and at the same time may be limited by their inability to forage in snow," Walsh writes. The presence of two distinct genetic clusters of this nomadic species--one on either... | Using general linear models, we found that measurements of genetic diversity across fifteen counties are best explained by days of snow on the ground. These models suggest opossum expansion may be facilitated by agricultural land development and at the same time be limited by their inability to forage in snow. In addit... | [5] | Biology | train | 5 | news | http://www.futurity.org/virginia-opossum-range-1684512/ |
10.1038/s41467-018-04627-5 | Biology_easy_32 | For example, the measurements might be picking up on increases in the number or size of certain types of cells that help nourish and maintain the white matter, or on added insulation for existing neural connections, Huber said. | Over the course of the intervention, only the posterior CC retained a relationship to Reading Skill. | Just what kind of tissue was created among reading program participants is likely to be the subject of future study, the authors said. For example, the measurements might be picking up on increases in the number or size of certain types of cells that help nourish and maintain the white matter, or on added insulation fo... | Anatomy-behavior correlations depend on recent experience. Over the course of the intervention, only the posterior CC retained a relationship to Reading Skill. In contrast, as MD values declined in the AF and ILF, the instantaneous, cross-sectional correlation between reading and MD changed between sessions, as indicat... | [1] | Biology | train | 1 | news | http://ct.moreover.com/?a=34305651947&p=1pl&v=1&x=5K-kiFIe9C-USZImgR7dwA |
10.1016/j.cmet.2015.02.003 | Biology_easy_33 | Healthy legs boasted no discernible concentrations of the mineral. | LPS boosted histone H3 lysine-4 trimethylation (H3K4me3) in the Nos2 gene (Figures S1D and S1E), indicating activation of Nos2 transcription . | Physicians found high concentrations of salt in the skin of patients' infected legs. Healthy legs boasted no discernible concentrations of the mineral. After treating the patients with antibiotics, the salt accumulation disappeared along with the infection. | Skin Na + concentrations (mean + SEM; n = 3). LPS boosted histone H3 lysine-4 trimethylation (H3K4me3) in the Nos2 gene (Figures S1D and S1E), indicating activation of Nos2 transcription . HS further augmented H3K4me3 at distinct regions in the Nos2 gene (Figures S1D and S1E). | [1] | Biology | train | 1 | news | http://www.upi.com/Science_News/2015/03/03/Scientists-say-salt-may-guard-against-infection/4511425414509/ |
10.1038/s41467-018-05870-6 | Biology_easy_36 | When they deleted Ago2 from the livers of mice, it was not toxic to the animals but it did stabilize energy metabolism. | While Ago2 protein levels were slightly decreased in the liver of mice fed HFD (Supplemental Fig. | When they deleted Ago2 from the livers of mice, it was not toxic to the animals but it did stabilize energy metabolism. This helped stave off obesity and prevented the mice from developing diabetes and fatty liver disease, which can severely damage the vital organ--which helps rid the body of toxic substances. "Althoug... | *p < 0.05, **p < 0.01 analysis revealed that hepatic Ago2 deficiency affected several functional clades such as glucose and lipid metabolism and protein translation regulation (Fig. While Ago2 protein levels were slightly decreased in the liver of mice fed HFD (Supplemental Fig. 6a ), several MD-miRNAs were highly indu... | [1] | Biology | train | 1 | news | http://ct.moreover.com/?a=37061323146&p=1pl&v=1&x=l5-40ws2AOkos3TN_hE55A |
10.1016/j.cell.2015.07.058 | Biology_easy_39 | This provides an elegant mechanism to neutralize viral replication without jeopardizing cellular viability. | Thus, even in the absence of E1B-55K-induced MRN degradation, E4-ORF3 sequesters MRE11 and NBS1 in DE1B-55K-infected cells ( Figures 1C and S1A ). | MRN starts a domino effect, activating histones on surrounding chromosomes, which summons a cascade of additional proteins, resulting in a cell-wide, all-hands-on-deck alarm to help mend the DNA. This provides an elegant mechanism to neutralize viral replication without jeopardizing cellular viability. Image: Courtesy ... | Consistent with this, MRE11 and RAD50 protein levels are decreased in WT and DE4-ORF3-virus-infected cells that express E1B-55K (Figure 1B) . Thus, even in the absence of E1B-55K-induced MRN degradation, E4-ORF3 sequesters MRE11 and NBS1 in DE1B-55K-infected cells ( Figures 1C and S1A ). However, DE1B-55K/DE4-ORF3 viru... | [1] | Biology | train | 1 | news | http://www.healthcanal.com/cancers/66433-the-dna-damage-response-goes-viral-a-way-in-for-new-cancer-treatments.html |
10.1016/j.cell.2018.06.045 | Biology_easy_40 | "Our results are important for better understanding the infection-sensitivity of newborn babies and the risks of premature birth," says Dr Brodin. | Another possible explanation is that some other physiological process, shared by all children, triggers the stereotypic immune system development, but the changes seen implicate interactions with microbes. | The researchers were also able to show that the babies who had abnormal development of the gut flora during the first weeks also demonstrated a disorder of the immune system. "Our results are important for better understanding the infection-sensitivity of newborn babies and the risks of premature birth," says Dr Brodin... | At the same time, gut microbiome composition differed between children, and the likelihood of shared exposures across such a diverse group of children seems unlikely. Another possible explanation is that some other physiological process, shared by all children, triggers the stereotypic immune system development, but th... | [1] | Biology | train | 1 | news | http://ct.moreover.com/?a=34897998946&p=1pl&v=1&x=xkojRQPNCvCSHFiL-aMHjA |
10.1016/j.cmet.2015.02.003 | Biology_easy_42 | "Our current study challenges this one-sided view and suggests that increasing salt accumulation at the site of infections might be an ancient strategy to ward off infections, long before antibiotics were invented." | LPS-treated BMM from LysM Cre Nfat5 fl/fl mice showed reduced NFAT5 expression and NO production when exposed to salt-induced osmotic stress ( Figure S3 ). | While too much salt may not be the best for your health, dietary salt could actually have some benefits. "Our current study challenges this one-sided view and suggests that increasing salt accumulation at the site of infections might be an ancient strategy to ward off infections, long before antibiotics were invented."... | These findings suggest that HSD promotes salt storage in the skin and facilitates leishmanicidal activity by enhancing NOS2 expression, especially during resolution phase of infection. LPS-treated BMM from LysM Cre Nfat5 fl/fl mice showed reduced NFAT5 expression and NO production when exposed to salt-induced osmotic s... | [1] | Biology | train | 1 | news | http://www.scienceworldreport.com/articles/22963/20150304/high-salt-diet-ward-infection-invading-microbes.htm |
10.1016/j.cell.2015.07.058 | Biology_easy_45 | "When MRN is recruited to cellular DNA breaks, it can no longer sense and respond to incoming viral genomes. | Similar to HU, KU-55933 prevents the phosphorylation of ATM, H2AX, RPA32, and KAP1 in WT-virus-infected cells (Figure 3B) . | "The requirement of MRN for sensing both cellular and viral genome breaks has profound consequences," says O'Shea. "When MRN is recruited to cellular DNA breaks, it can no longer sense and respond to incoming viral genomes. O'Shea says this may explain why people with conditions resulting in high levels of cellular DNA... | We conclude that global DDR signaling is activated downstream of viral DNA replication. Similar to HU, KU-55933 prevents the phosphorylation of ATM, H2AX, RPA32, and KAP1 in WT-virus-infected cells (Figure 3B) . HU and KU-55933 also prevent the phosphorylation of DNA-PKcs ( Figure 3B ), indicating that DNA-PK is activa... | [1] | Biology | train | 1 | news | http://www.healthcanal.com/cancers/66433-the-dna-damage-response-goes-viral-a-way-in-for-new-cancer-treatments.html |
10.1038/ncomms4632 | Biology_easy_46 | Fan and her team are the first to achieve the extremely difficult goal of designing a nanomotor with large driving power. | By controlling the durations of the combined AC and DC E-fields in both the X and Y directions, the nanowires can be precisely manipulated in two dimensions along prescribed trajectories to the patterned magnetic bearings as shown in Fig. | The team's three-part nanomotor can rapidly mix and pump biochemicals and move through liquids, which is important for future applications. Fan and her team are the first to achieve the extremely difficult goal of designing a nanomotor with large driving power. With all its dimensions under 1 micrometer in size, the na... | The magnetic attraction can be adjusted so precisely that it can anchor the nanowires to the bearings, but not too tightly to prevent the nanowires from rotating. By controlling the durations of the combined AC and DC E-fields in both the X and Y directions, the nanowires can be precisely manipulated in two dimensions ... | [1] | Biology | train | 1 | news | http://www.sciencedaily.com/releases/2014/05/140520123441.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily+%28Latest+Science+News+--+ScienceDaily%29 |
10.1016/j.cell.2015.10.009 | Biology_easy_47 | However, it was still able to cause septicemic and pneumonic plague,aEUR Rasmussen added. | However, our data suggest that Y. pestis did not fully adapt as a flea-borne mammalian pathogen until the beginning of the 1 st millennium BC, which precipitated the historically recorded plagues. | aEURoeThe Bronze Age plague represents an intermediate state where it had not yet evolved the capabilities to be transmitted by fleas or cause bubonic plague. However, it was still able to cause septicemic and pneumonic plague,aEUR Rasmussen added. The germ was spread mainly by such human-to-human contact until a genet... | In light of our findings, it is plausible that plague outbreaks could have facilitated-or have been facilitated by-these highly dynamic demographic events. However, our data suggest that Y. pestis did not fully adapt as a flea-borne mammalian pathogen until the beginning of the 1 st millennium BC, which precipitated th... | [1] | Biology | train | 1 | news | http://healthmedicinet.com/news/black-death-germ-has-afflicted-humankind-longer-than-suspected/ |
10.1186/1471-2164-15-599 | Biology_easy_48 | This provides researchers with a new vision on human evolution. | As shown here for humans, in bacteria, a correlation between species-specific protein evolutionary rate variation and positive selection signatures by the MK test was found . | This provides researchers with a new vision on human evolution. "If a mutation or a change increases the chances of survival in the person carrying it, this mutation will tend to become prevalent in the population. The new protein will have changed its function compared to the ancestral protein. | Genes in the accelerated gene set showed remarkably high non-synonymous to synonymous substitutions; however, this alone was not sufficient to explain their high FI values, as deduced from the comparison with similarly rapidly evolving genes that were not human accelerated or with the set of rapidly evolving mammalians... | [1] | Biology | train | 1 | news | http://www.healthcanal.com/genetics-birth-defects/53316-identified-almost-200-genes-that-have-evolved-more-rapidly-in-humans-than-in-other-primates.html |
10.1038/nature12167 | Biology_easy_49 | "This work highlights the need to modify how we classify the GPCR family," said TSRI Professor Raymond Stevens, PhD, the senior author on the study. | Moreover, the SMO receptor can couple to G proteins, particularly G i , which inhibits cAMP production, controlling cell migration . | However, the new work suggests that GPCRs may, in fact, be a subset of a larger group. "This work highlights the need to modify how we classify the GPCR family," said TSRI Professor Raymond Stevens, PhD, the senior author on the study. "The study suggests we should start calling the family 7-transmembrane receptors, wh... | The 7TM domains of SMO and FZD receptors are reminiscent of class A GPCRs 12 although their sequences are distinct from other GPCRs, sharing less than 10% sequence identity. Moreover, the SMO receptor can couple to G proteins, particularly G i , which inhibits cAMP production, controlling cell migration . 1 ) reveals a... | [1] | Biology | train | 1 | news | http://www.healthcanal.com/medical-breakthroughs/38297-scripps-research-institute-scientists-find-dissimilar-proteins-evolved-similar-7-part-shape.html |
10.1186/s40168-015-0071-z | Biology_easy_50 | The authors found that the intestinal tracts of infants fed by non-secretor mothers are delayed in establishing a bifidobacteria-dominated microbiota. | As expected, glycan presence was not significantly different between samples with different major bifidobacterial species in Low-Bif qPCR stool, as bifidobacteria were not likely the major glycan consumer in samples where they were not abundant (data not shown). | The study found that, on average, Bifidobacterium were established earlier and more frequently in infants fed by women with an active copy of the gene, the secretors, than without one, the non-secretors. The authors found that the intestinal tracts of infants fed by non-secretor mothers are delayed in establishing a bi... | longum were of roughly equal abundance and, thus, were designated more generally as 'B. As expected, glycan presence was not significantly different between samples with different major bifidobacterial species in Low-Bif qPCR stool, as bifidobacteria were not likely the major glycan consumer in samples where they were ... | [1] | Biology | train | 1 | news | http://www.sciencedaily.com/releases/2015/04/150409143035.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily+%28Latest+Science+News+--+ScienceDaily%29 |
10.1016/j.stemcr.2018.03.019 | Biology_easy_51 | So the female iPS cells now have two active X chromosomes, while males have only one. | Interestingly, we found that within several of these cis-regulatory regions, changes in average methylation levels were already apparent in both SSEA1 subpopulations, and more pronounced in XaXa iPSCs (Figures 3D-3G) . | But when these cells are reprogrammed into iPS cells, the inactive X becomes active. So the female iPS cells now have two active X chromosomes, while males have only one. We now know that this explains the different behaviour of male and female cells after reprogramming because, over time, female cells lose one of the ... | Together, these results indicate that imprints are not only erased in XX iPSCs but also are not re-established upon global genome remethylation in XO iPSCs, which suggests that female iPSCs, regardless of the number of Xas, may have a similarly poor developmental potential as female ESCs . Interestingly, we found that ... | [1] | Biology | train | 1 | news | http://ct.moreover.com/?a=33847856937&p=1pl&v=1&x=vV_Dne2GAjTKIkp14dSTOw |
10.1038/s41467-019-09863-x | Biology_easy_52 | We still have a lot of work to do in figuring out the best way to curb climate change, but there is a clear consensus that the priciest option is to do nothing. | The version of JULES used here has an improved representation of physical and biogeochemical processes in the cold regions 80 . | "Although between-country inequality has decreased over the past half century, there is ~90 percent likelihood that global warming has slowed that decrease," the authors said. Opposition to these plans is often based on the costs involved in implementing them, but these two new studies offer a powerful counterpoint to ... | The simulated CO 2 and methane fluxes from thawing permafrost as a function of time represent the strength and timing of the PCF. The version of JULES used here has an improved representation of physical and biogeochemical processes in the cold regions 80 . C max is a limit on the maximum possible cumulative emissions ... | [1] | Biology | train | 1 | news | http://ct.moreover.com/?a=39063152220&p=1pl&v=1&x=rfZKa3AOnuRs3Dq6otYxhw |
10.1016/j.cell.2018.04.038 | Biology_easy_53 | advertisement
This is the first time researchers have seen telomerase in the process of making DNA. | While the TRE-template-TBE play direct regulatory roles in sstDNA synthesis, other elements of TER in the catalytic core function in assembly, as structural scaffolds or as linkers. | Many mutations that scientists attributed to the TEN region in fact disrupt TEN's interaction with TRAP, the researchers report in Cell. advertisement
This is the first time researchers have seen telomerase in the process of making DNA. This new research brings this goal closer to reality by providing clues about what... | Differences observed in the DNA-free and DNA-bound telomerase density maps indicate that the TRAP-TRE L interaction stabilizes and/or extends the TRAP-TEN interface ( Figures S3E and S3F ). While the TRE-template-TBE play direct regulatory roles in sstDNA synthesis, other elements of TER in the catalytic core function ... | [1] | Biology | train | 1 | news | http://ct.moreover.com/?a=34239565585&p=1pl&v=1&x=dKdwlCB2iE4axi2krXvE_w |
10.1373/clinchem.2012.187617 | Biology_easy_55 | This is actually through our microbiome's connection to the immune system. | SCFAs may function as microbe-derived signals that influence carbohydrate metabolism and gut physiology by stimulating mammalian peptide secretion and serving as energy sources for gut epithelial cells. | These little guys play a huge role in regulating our health and make it possible for us to live in the way we're used to. This is actually through our microbiome's connection to the immune system. They aren't hurting us as long as they stay under control. | SCFAs such as propionate can be used for de novo glucose or lipid synthesis and serve as an energy source for the host. SCFAs may function as microbe-derived signals that influence carbohydrate metabolism and gut physiology by stimulating mammalian peptide secretion and serving as energy sources for gut epithelial cell... | [1] | Biology | train | 1 | news | http://ct.moreover.com/?a=40253496747&p=1pl&v=1&x=Ul5zHhtDyat4L2c3FwEaew |
10.1098/rsos.171474 | Biology_easy_56 | "They might think Fortnite is violent or that people who play Mario are more likely to be aggressive towards turtles. | Finally, in this study, we draw general inferences about gaming effects in a general way across the population as a whole. | He found that people who have never played video games before are more likely to have biases about them and unrealistic expectations about them. "They might think Fortnite is violent or that people who play Mario are more likely to be aggressive towards turtles. But once you get the hands-on experience, you see that th... | To this end, field or natural experiments using multi-wave random-intercepts cross-lagged panel modelling should follow the present work to provide an expanded test of the effects of violent gaming on human behaviour. Finally, in this study, we draw general inferences about gaming effects in a general way across the po... | [1] | Biology | train | 1 | news | http://ct.moreover.com/?a=39882021759&p=1pl&v=1&x=WDSVA9_GGY2tcF2kX9kO8w |
10.1016/j.mito.2018.08.001 | Biology_easy_57 | "Once the triggers of a chronic injury have been identified and removed, and on-going symptoms treated, we need to think about fixing the underlying issue of impaired healing. | The good news is that the dauer state in the worm model is completely reversible. | When the cast is removed, the limb is weak, but over time, muscles recover and bone that was once broken may actually be stronger." "Once the triggers of a chronic injury have been identified and removed, and on-going symptoms treated, we need to think about fixing the underlying issue of impaired healing. By shifting ... | Overall, the dauer state and other hypometabolic states permit survival under harsh conditions, but at a high price of much-altered and much-restricted normal function. The good news is that the dauer state in the worm model is completely reversible. If dauer is a good model for ME/CFS, then there is hope that by study... | [1] | Biology | train | 1 | news | http://ct.moreover.com/?a=37036494336&p=1pl&v=1&x=fSLbjdg9pAN1rFXsEu2RGA |
10.1038/s41467-019-09863-x | Biology_easy_59 | Even if action is taken to limit warming to 1.5degC by the end of the century, the research found melting permafrost would still add $24.8 trillion to overall climate costs. | Compared with zero PCF and constant SAF, which are the legacy values that have been used in climate policy modelling to date, the combined nonlinear PCF and SAF cause statistically significant extra warming globally under the low and medium emissions scenarios. | Even if action is taken to limit warming to 1.5degC by the end of the century, the research found melting permafrost would still add $24.8 trillion to overall climate costs. In an interview with the Guardian, Yumashev called his study's results "disheartening," but said nations of the world have the technological capac... | The PCF also develops state-dependent lagged behaviour. Compared with zero PCF and constant SAF, which are the legacy values that have been used in climate policy modelling to date, the combined nonlinear PCF and SAF cause statistically significant extra warming globally under the low and medium emissions scenarios. Fo... | [1] | Biology | train | 1 | news | http://ct.moreover.com/?a=39059198716&p=1pl&v=1&x=LFeOjGrAvD1wF12D7W6Wvg |
10.1016/j.neuron.2017.06.028 | Biology_easy_60 | When we identified some of the mechanisms underlying this regulation, I was amazed by how a single protein can act as an activity sensor, orchestrate such a complex molecular program and simultaneously influence several key cellular processes', said Dr Emilia Favuzzi, first author of the study from the Centre for Devel... | Specifically, expression of the GPI-anchored isoform of BCAN by PV+ cells is responsible for regulating the density of their excitatory synapses. | These novel findings show that Brevican is dynamically regulated by experiences coming from the environment and is fundamentally required for spatial working memory and short-term memories. When we identified some of the mechanisms underlying this regulation, I was amazed by how a single protein can act as an activity ... | In this study, we have shown that PV+ interneurons expressing BCAN receive more glutamatergic inputs than similar cells lacking BCAN. Specifically, expression of the GPI-anchored isoform of BCAN by PV+ cells is responsible for regulating the density of their excitatory synapses. In addition, release of BCAN2 from astro... | [1] | Biology | train | 1 | news | http://healthmedicinet.com/news/how-neurons-sense-our-everyday-life/ |
10.1016/j.cell.2015.07.058 | Biology_easy_62 | The cell detects the unauthorized replication and the MRN complex grabs and selectively neutralizes viral DNA without triggering a global response that would arrest or kill the cell. | Furthermore, capsid protein expression and total virus titers are similar in WT-virusinfected cells treated with DMSO, or AZ20 (Figures S3F and S3G) . | When it comes to defending against DNA viruses, however, the Salk team found something interesting: the cell's response system begins the same way (with MRN detecting either DNA or viral breaks) but never progresses to the global alarm signal in the case of the virus. The cell detects the unauthorized replication and t... | KU-55933 has no impact on WT virus genome replication levels ( Figure 3H ). Furthermore, capsid protein expression and total virus titers are similar in WT-virusinfected cells treated with DMSO, or AZ20 (Figures S3F and S3G) . ATM inhibition also does not impact the cytopathic effect associated with WT virus replicatio... | [1] | Biology | train | 1 | news | http://www.healthcanal.com/cancers/66433-the-dna-damage-response-goes-viral-a-way-in-for-new-cancer-treatments.html |
10.1126/sciadv.1700581 | Biology_easy_64 | "This brings on a compound effect and increases the overall drought impact significantly. | These impacts are especially worth considering for the 278 transboundary waterways (37) associated with shared watersheds occupying nearly half of the world's land . | "Most importantly, our findings also showed a steep rise in the simultaneous occurrence of multiple drought types," said lead author Deepthi Rajsekhar, a former postdoctoral scholar in Gorelick's lab now working at the California Department of Water Resources. "This brings on a compound effect and increases the overall... | Water security assessments spanning future decades would greatly benefit from reflecting on the joint impacts of multiple drought types and humaninduced land-use change. These impacts are especially worth considering for the 278 transboundary waterways (37) associated with shared watersheds occupying nearly half of the... | [1] | Biology | train | 1 | news | https://www.sciencedaily.com/releases/2017/08/170830202128.htm |
10.1073/pnas.1511220112 | Biology_easy_65 | The researchers' next step will be to analyze variability in the shoulder blade of modern humans and the genetic sequences that cause those differences to understand how these factors influence the likelihood to get rotator cuff injuries. | This final shift toward a fully lateralized spine and glenoid was likely costly to climbing efficiency and/or arm hanging , while also increasing shear stress at the shoulder and elevating the risk of rotator cuff injury . | "For a baseball pitcher, depending on your shoulder shape, you might want to emphasize some strengthening exercises over others to protect your rotator cuff." The researchers' next step will be to analyze variability in the shoulder blade of modern humans and the genetic sequences that cause those differences to unders... | Interestingly, the later A. sediba has a more human-like shoulder compared with earlier A. afarensis, suggesting that the ancestor of A. sediba and Homo shared the more derived configuration. This final shift toward a fully lateralized spine and glenoid was likely costly to climbing efficiency and/or arm hanging , whil... | [1] | Biology | train | 1 | news | http://www.technology.org/2015/09/09/shouldering-burden-evolution/ |
10.1080/10635150701775111 | Biology_easy_66 | In all three cases, the data was limited, especially in the case of the ecological niche modeling. | However, the inclusion of many more species is needed to explore the full biogeographic history of this group, especially concerning continental speciation within Madagascar itself. | He admits three specimens was not a lot, but "the whole genome data of one passenger pigeon carries the information of the whole species." In all three cases, the data was limited, especially in the case of the ecological niche modeling. Yet, Chih-Ming is confident. | Our preliminary analysis based on 12S mtDNA (not shown) finds the Zanzibar specimen falling in a clade with P. ravenala and the other Comoros specimens forming a polytomy with P. dubia from Northwest Madagascar. However, the inclusion of many more species is needed to explore the full biogeographic history of this grou... | [1] | Biology | train | 1 | news | http://arstechnica.com/science/2014/06/humans-not-entirely-at-fault-for-passenger-pigeon-extinction/ |
10.1038/s41467-018-05229-x | Biology_easy_67 | In a bulk solid, Wannier-Stark localization can only be maintained for an extremely short period of time, shorter than a single oscillation of infrared light. | In the high-field regime, wave functions (gray) are confined to a small number of lattice sites. | "This fundamental effect was predicted more than 80 years ago. In a bulk solid, Wannier-Stark localization can only be maintained for an extremely short period of time, shorter than a single oscillation of infrared light. Using the ultrafast laser systems at the University of Konstanz, Wannier-Stark localization has no... | Airy-type envelope wave functions extending over many lattice sites lead to finite transition probabilities for energies below the unbiased bandgap energy E gap (red arrow) and oscillating absorption changes in the interband continuum above E gap (orange arrow). In the high-field regime, wave functions (gray) are confi... | [1] | Biology | train | 1 | news | http://ct.moreover.com/?a=34669971079&p=1pl&v=1&x=vdqBVutlRrBG6NrsU9ADLw |
10.1098/rsos.180695 | Biology_easy_68 | Interestingly, citizen scientists in Alaska also reported indoor conditions most similar to those in Namibia. | This literature suggests that the many ways in which the climate people prefer for their homes might be modulated and why. | For example, citizens in North Carolina reported indoor conditions most like those in Namibia, which is in southern Africa and south of the equator. Interestingly, citizen scientists in Alaska also reported indoor conditions most similar to those in Namibia. "Only three states reported indoor conditions that were most ... | Thermal comfort can be influenced by culture , by wind speed and humidity [27 -30] and mean radiant temperature . This literature suggests that the many ways in which the climate people prefer for their homes might be modulated and why. But what these do not change is the reality that thermal comfort itself, evolved. | [1] | Biology | train | 1 | news | http://ct.moreover.com/?a=38804472041&p=1pl&v=1&x=HgOgei0b1kV3BVEuJ5LhBA |
10.1038/s41396-017-0042-4 | Biology_easy_69 | So essentially ... none of these microbes statistically speaking would infect humans, so it's not something we have to worry about." | These deposition rates were 9-461 times greater than the rates for bacteria, which ranged from 0.3 × 10 7 to >8 × 10 7 m −2 per day. | However, the rain was less efficient removing viruses from the atmosphere," said author and microbial ecologist Isabel Reche from the University of Granada
It may sound like something out of a science fiction movie, but it's not quite so perilous. Suttle explains that early all of the viruses circulating and dropping ... | Here, we demonstrate that even in pristine environments, above the atmospheric boundary layer, the downward flux of viruses ranged from 0.26 × 10 9 to >7 × 10 9 m −2 per day. These deposition rates were 9-461 times greater than the rates for bacteria, which ranged from 0.3 × 10 7 to >8 × 10 7 m −2 per day. The highest ... | [1] | Biology | train | 1 | news | http://ct.moreover.com/?a=33888158467&p=1pl&v=1&x=tFCRvwLCRGyes3rifRfszA |
10.2337/db13-1600 | Biology_easy_71 | "The more tightly doctors try to control patients' blood glucose, the more episodes of hypoglycemia the patients experience. | Decreasing the responsiveness of these neurons to any single molecule might, in turn, allow them to respond or integrate a variety of incoming signals to help achieve the appropriate motor response. | The end result, Donovan said, is a vicious cycle. "The more tightly doctors try to control patients' blood glucose, the more episodes of hypoglycemia the patients experience. And the more episodes they experience, the less ability they have to counter-regulate or combat the onset of hypoglycemia and so these people bec... | Perhaps CNS glucose sensors are insensitive to slow or small glycemic changes, thereby serving as a "fail safe" mechanism for catastrophic declines in glucose. Decreasing the responsiveness of these neurons to any single molecule might, in turn, allow them to respond or integrate a variety of incoming signals to help a... | [1] | Biology | train | 1 | news | http://www.healthcanal.com/metabolic-problems/diabetes/49962-diabetes-detectives.html |
10.1016/j.compag.2016.07.028 | Biology_easy_72 | Ge and Schnable found that the software's estimates of plant size correlated strongly with their own measurements of plant weight, leaf area and water use efficiency. | Advancement in plant phenomics would enable more effective utilization of genetic data, and ultimately lead to novel gene discovery and improved crop yield and quality in the field. | Second sight
Ge and Schnable also showed that conventional RGB imagery from the phenotyping system can be used to estimate the daily growth of corn plants - and how efficiently they use water to stimulate that growth - during their first few weeks of development. Ge and Schnable found that the software's estimates of ... | It would fill the gap between the low cost of generating large scale datasets of plant genotypes and the time consuming and expensive process of collecting large scale plant phenotypic datasets. Advancement in plant phenomics would enable more effective utilization of genetic data, and ultimately lead to novel gene dis... | [1] | Biology | train | 1 | news | http://feedproxy.google.com/~r/TechnologyOrg/~3/JM-jhIn6rZA/ |
10.1073/pnas.1414221111 | Biology_easy_75 | After 48 hours the parasite was undetectable. | These morphological changes reach a maximum by 7-8 h after treatment. | In a mouse model of malaria, a single dose of (+)-SJ733 killed 80 percent of malaria parasites within 24 hours. After 48 hours the parasite was undetectable. Planning has begun for safety trials of the compound in healthy adults. | This immediate response triggers other cellular responses, probably including the arrest of protein synthesis , and these are integrated at the level of both the parasite (manifested as a swollen, development-arrested phenotype) and the host erythrocyte (manifested as induction of an eryptotic/senescent phenotype). The... | [1] | Biology | train | 1 | news | http://www.sciencedaily.com/releases/2014/12/141205175027.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily%2Ftop_news%2Ftop_science+%28ScienceDaily%3A+Top+Science+News%29 |
10.1038/s41396-017-0042-4 | Biology_easy_76 | Suttle explains that early all of the viruses circulating and dropping from the Earth's atmosphere actually help regulate ecosystems across the planet. | Samples that were predominantly marine in origin are shown as blue circles, and samples with predominantly Saharan in origin are shown as orange circles transformed) were positively correlated with this larger size fraction of organic aerosol (n = 36, r = 0.38, p < 0.05) (Fig. | However, the rain was less efficient removing viruses from the atmosphere," said author and microbial ecologist Isabel Reche from the University of Granada
It may sound like something out of a science fiction movie, but it's not quite so perilous. Suttle explains that early all of the viruses circulating and dropping ... | Virus deposition rates were significantly correlated to the organic fraction of aerosols smaller than 0.7 μm (n = 32, r = 0.62, p < 0.01), whereas bacteria deposition rates were significantly correlated to the organic fraction of aerosols with a size >0.7 μm (n = 36, r = 0.38, p < 0.05). Samples that were predominantly... | [1] | Biology | train | 1 | news | http://ct.moreover.com/?a=33888158467&p=1pl&v=1&x=tFCRvwLCRGyes3rifRfszA |
10.1073/pnas.1601081113 | Biology_easy_77 | (Photo : Frank Vassen/Wikimedia Commons)
Apart from being adorably cute, mouse lemurs' DNA could hold the key in revealing the mysterious past of the island nation of Madagascar. | Phylogeographic analysis can be described as the study of the geological and climatological processes that have produced contemporary geographic distributions of populations and species. | (Photo : Frank Vassen/Wikimedia Commons)
Apart from being adorably cute, mouse lemurs' DNA could hold the key in revealing the mysterious past of the island nation of Madagascar. But this study reveals that the answer to this bugging mystery is embedded in the tiny lemurs roaming in the island nation. Yoder and her te... | By examining patterns of both inter-and intraspecific genetic diversity in mouse lemur species found in the eastern, western, and Central Highland zones, we conclude that the natural environment of the Central Highlands would have been mosaic, consisting of a matrix of wooded savanna that formed a transitional zone bet... | [1] | Biology | train | 1 | news | http://www.natureworldnews.com/articles/25503/20160719/cute-mouse-lemurs-solve-mystery-madagascar-past.htm |
10.1016/j.molcel.2014.05.030 | Biology_easy_79 | "If you tend to burn, then you may have inherited a problem with your MC1R, and you probably should avoid purposeful UV exposure like tanning bed use or unprotected sun exposure." | We found that cAMP signaling influenced kinetics of XPA nuclear accumulation and recruitment to chromatin after UV-induced DNA damage (Figures 2A, 2B and 2C) . | "If you tan well, then your MC1R probably works well," D'Orazio said. "If you tend to burn, then you may have inherited a problem with your MC1R, and you probably should avoid purposeful UV exposure like tanning bed use or unprotected sun exposure." D'Orazio and his research team found an important molecular link betwe... | cAMP stimulation failed to increase total protein levels of core NER factors ( Figure S3A ), however we explored whether distribution of key NER proteins to sites of UV-induced DNA damage might be affected. We found that cAMP signaling influenced kinetics of XPA nuclear accumulation and recruitment to chromatin after U... | [1] | Biology | train | 1 | news | http://www.sciencedaily.com/releases/2014/07/140715141753.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily+%28Latest+Science+News+--+ScienceDaily%29 |
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