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"O",
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"O",
"B-T038",
"I-T038",
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"... | [
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"db_id": null,... | [
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... | Dupuytren in a Child: Rare Presentation of a Rare Clinical Entity Dupuytren disease in children younger than 10 years is rare and only 8 histologically proven cases have been reported. A histologically proven Dupuytren disease in a 10-year-old with an uncommon clinical presentation as a nodule on the radial side of the middle phalanx of the little finger is documented. Dupuytren's disease should be in the differential diagnosis in cases of nodules and contractures in the palm and fingers of children. |
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"B-T082",
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"O",
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"B-T204",
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"O",
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"I-T062",
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"I-T082",
"O",
"B-T038",
"O",
"O",
"O",
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"O",
"O",
"O",... | [
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"db_id... | [
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7... | High malaria transmission in a forested malaria focus in French Guiana: How can exophagic Anopheles darlingi thwart vector control and prevention measures? In French Guiana, malaria vector control and prevention relies on indoor residual spraying and distribution of long lasting insecticidal nets. These measures are based on solid epidemiological evidence but reveal a poor understanding of the vector. The current study investigated the behaviour of both vectors and humans in relation to the ongoing prevention strategies. In 2012 and 2013, Anopheles mosquitoes were sampled outdoors at different seasons and in various time slots. The collected mosquitoes were identified and screened for Plasmodium infection. Data on human behaviour and malaria episodes were obtained from an interview. A total of 3,135 Anopheles mosquitoes were collected, of which Anopheles darlingi was the predominant species (96.2%). For the December 2012-February 2013 period, the Plasmodium vivax infection rate for An. darlingi was 7.8%, and the entomological inoculation rate was 35.7 infective bites per person per three-month span. In spite of high bednet usage (95.7%) in 2012 and 2013, 52.2% and 37.0% of the participants, respectively, had at least one malaria episode. An. darlingi displayed heterogeneous biting behaviour that peaked between 20:30 and 22:30; however, 27.6% of the inhabitants were not yet protected by bednets by 21:30. The use of additional individual and collective protective measures is required to limit exposure to infective mosquito bites and reduce vector densities. |
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"O",
"O",
"O",
"O",
"O",
"O",
"B-T103",
"O",
"O",
"O",
"O",
"O",
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"B-T170",
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"I-T058",
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"I-T058",
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"B-T082",
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"B-... | [
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... | [
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6... | A framework for automatic creation of gold - standard rigid 3D-2D registration datasets Advanced image-guided medical procedures incorporate 2D intra-interventional information into pre-interventional 3D image and plan of the procedure through 3D / 2D image registration (32R). To enter clinical use, and even for publication purposes, novel and existing 32R methods have to be rigorously validated. The performance of a 32R method can be estimated by comparing it to an accurate reference or gold standard method (usually based on fiducial markers) on the same set of images (gold standard dataset). Objective validation and comparison of methods are possible only if evaluation methodology is standardized, and the gold standard dataset is made publicly available. Currently, very few such datasets exist and only one contains images of multiple patients acquired during a procedure. To encourage the creation of gold standard 32R datasets, we propose an automatic framework. The framework is based on rigid registration of fiducial markers. The main novelty is spatial grouping of fiducial markers on the carrier device, which enables automatic marker localization and identification across the 3D and 2D images. The proposed framework was demonstrated on clinical angiograms of 20 patients. Rigid 32R computed by the framework was more accurate than that obtained manually, with the respective target registration error below 0.027 mm compared to 0.040 mm. The framework is applicable for gold standard setup on any rigid anatomy, provided that the acquired images contain spatially grouped fiducial markers. The gold standard datasets and software will be made publicly available. |
[
"O",
"O",
"O",
"O",
"O",
"B-T201",
"I-T201",
"I-T201",
"O",
"B-T038",
"I-T038",
"O",
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"O",
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"I-T038",
"O",
"B-T038",
"I-T038",
"O",
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"O",
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"O",
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"O",
"O",
"O",
"B-T033",... | [
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"db_id": "C000... | [
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9... | Reduced compensatory responses to maintain central blood volume during hypovolemic stress in women with vasovagal syncope Although vasovagal syncope (VVS) is a common clinical condition the underlying pathophysiology is not fully understood. A decrease in cardiac output has recently been suggested as a determinant factor for orthostatic VVS. The aim was to investigate compensatory mechanisms to maintain central blood volume and venous return during hypovolemic stress in women with VVS. 14 VVS women (25.7±5.0 years) and 15 matched controls (22.8±3.2 years) were investigated. Single step and graded lower body negative pressure (LBNP) to presyncope was used to create hypovolemic stress. Peripheral mobilization of venous blood from the arm (capacitance response and net capillary fluid absorption) and lower limb blood pooling (calf capacitance response) were evaluated with volumetric technique. Cardiovascular responses and plasma norepinephrine (P-NE) were measured. Resting P-NE was elevated in VVS (P<0.01). Despite similar hypovolemic stimulus, VVS displayed blunted increase in P-NE (P<0.01) and reduced maximal percentage increase in TPR (P<0.05) during graded LBNP. Arm capacitance response was slower (P<0.05) and reduced in VVS at higher levels of LBNP (P<0.05). Capillary fluid absorption from extra- to intravascular space was reduced by almost 40% in VVS (P<0.05). Accordingly, a more pronounced reduction in CO was found (P<0.05). In conclusion, women with VVS presented with decreased mobilization of peripheral venous blood and decreased net fluid absorption from tissue to blood during hypovolemic stress, partly explained by an attenuated vasoconstrictor response. This may seriously impede maintenance of cardiac output during hypovolemic stress and could contribute to the pathogenesis of VVS. |
[
"O",
"B-T058",
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"I-T058",
"O",
"O",
"O",
"O",
"B-T058",
"I-T058",
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"I-T058",
"I-T058",
"O",
"B-T092",
"I-T092",
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"I-T170",
"O",
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"O",
"O",
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"O",
"O",
... | [
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... | [
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7... | The health care experience of patients with cancer during the last year of life: Analysis of the SEER - CAHPS data set Providing high-quality medical care for individuals with cancer during their last year of life involves a range of challenges. An important component of high-quality care during this critical period is ensuring optimal patient satisfaction. The objective of the current study was to assess factors influencing health care ratings among individuals with cancer within 1 year before death. The current study used the Surveillance, Epidemiology, and End Results (SEER)- Consumer Assessment of Healthcare Providers and Systems (CAHPS) data set, a new data resource linking patient-reported information from the CAHPS Medicare Survey with clinical information from the National Cancer Institute's SEER program. The study included 5102 Medicare beneficiaries diagnosed with cancer who completed CAHPS between 1998 and 2011 within 1 year before their death. Multivariable logistic regression analyses examined associations between patient demographic and insurance characteristics with 9 measures of health care experience. Patients with higher general or mental health status were significantly more likely to indicate excellent experience with nearly all measures examined. Sex, race/ethnicity, and education also were found to be significant predictors for certain ratings. Greater time before death predicted an increased likelihood of higher ratings for health plan and specialist physician. Clinical characteristics were found to have few significant associations with experience of care. Individuals in fee-for-service Medicare plans (vs Medicare Advantage) had a greater likelihood of excellent experience with health plans, getting care quickly, and getting needed care. Among patients with cancer within 1 year before death, experience with health plans, physicians, and medical care were found to be associated with sociodemographic, insurance, and clinical characteristics. These findings provide guidance for the development of programs to improve the experience of care among individuals with cancer. Cancer 2017;123:336-344. © 2016 American Cancer Society. |
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"O",
"O",
"O",
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"O",
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"db_id": "C1533734",
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"db_id": "C1533734",
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67... | Central apelin-13 administration modulates hypothalamic control of feeding The 77 amino prepropeptide apelin has been isolated from bovine stomach tissue and several smaller fragments, including apelin-13, showed high affinity for the orphan APJ receptor. The distribution of apelinergic fibers and receptors in the hypothalamus may suggest a role of apelin-13 on energy balance regulation, albeit the studies reporting the acute effects of apelin on feeding control are inconsistent. Considering the possible involvement of apelinergic system on hypothalamic appetite controlling network, in the present study we evaluated in the rat the effects of intrahypothalamic apelin-13 injection on food intake and the involvement of orexigenic and anorexigenic hypothalamic peptides and neurotransmitters. Eighteen rats (6 for each group of treatment) were injected into the ARC with either vehicle or apelin-13 (1-2 μg/ rat). Food intake and hypothalamic peptide and neurotransmitter levels were evaluated 2 and 24 h after injection. Compared to vehicle, apelin-13 administration increased food intake both 2 and 24 h following treatment. This effect could be related to inhibited cocaine- and amphetamine-regulated transcript (CART) gene expression and serotonin (5-hydroxytryptamine, 5-HT) synthesis and release, and increased orexin A gene expression in the hypothalamus. |
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"db_id": "C4048329",
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92,... | RPN13/ADRM1 inhibitor reverses immunosuppression by myeloid-derived suppressor cells Myeloid-derived-suppressor cells (MDSCs) are key mediators of immune suppression in the ovarian tumor microenvironment. Modulation of MDSC function to relieve immunosuppression may enhance the immunologic clearance of tumors. The bis-benzylidine piperidone RA190 binds to the ubiquitin receptor RPN13/ADRM1 on the 19S regulatory particle of the proteasome and directly kills ovarian cancer cells by triggering proteotoxic stress. Here we examine the effect of RA190 treatment on the immunosuppression induced by MDSCs in the tumor microenvironment, specifically on the immunosuppression induced by MDSCs. We show that RA190 reduces the expression of Stat3 and the levels of key immunosuppressive enzymes and cytokines arginase, iNOS, and IL-10 in MDSCs, while boosting expression of the immunostimulatory cytokine IL-12. Furthermore, we show that the RA190 -treated MDSCs lost their capacity to suppress CD8+ T cell function. Finally, we show that RA190 treatment of mice bearing syngeneic ovarian tumor elicits potent CD8+ T cell antitumor immune responses and improves tumor control and survival. These data suggest the potential of RA190 for ovarian cancer treatment by both direct killing of tumor cells via proteasome inhibition and relief of MDSC -mediated suppression of CD8 T cell -dependent antitumor immunity elicited by the apoptotic tumor cells. |
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8... | Poorer breast cancer survival outcomes in males than females might be attributable to tumor subtype Substantial controversy exists regarding the differences in tumor subtypes between male breast cancer (MBC) and female breast cancer (FBC). This is the largest population-based study to compare MBC and FBC patients. Using data obtained by the Surveillance, Epidemiology, and End Results (SEER) program from 2010-2012, a retrospective, population-based cohort study was conducted to investigate tumor subtype - specific differences in various characteristics, overall survival (OS) and breast cancer-specific mortality (BCSM) between males and females. In all, 181,814 BC patients (1,516 male and 180,298 female) were eligible for this study. The male patients were more likely to be black, older, and have lower histological grades, more advanced stages, larger tumors, more lymph node and distant metastases and human epidermal growth factor receptor 2 (HER2)- negative tumors (each p<0.05). A matched analysis showed that the 2-year OS was 91.2% and 93.7% and that the BCSM was 2.2% and 2.5% for male and female patients, respectively. The univariate analysis showed that male triple-negative (TN), hormone receptor (HoR)-positive/HER2-positive and HoR-positive/HER2-negative patients had poorer OS (p <0.01). Meanwhile, the HoR-positive/HER2-positive and TN subtypes were associated with a higher BCSM in MBC patients (p<0.01). The multivariate analysis revealed that TN MBC patients had poorer OS and BCSM (p<0.05). Simultaneously, the results showed that male patients in the HoR-positive/HER2-negative subgroup were less likely to die of BC when adjusting for other factors (p<0.05). The analysis of 2-year OS and BCSM among the BC subtypes showed clear differences between MBC and FBC patients with the TN subtype; these differences warrant further investigation. |
[
"O",
"O",
"B-T033",
"I-T033",
"O",
"O",
"B-T038",
"O",
"B-T038",
"I-T038",
"I-T038",
"B-T103",
"I-T103",
"I-T103",
"O",
"B-T103",
"O",
"O",
"O",
"B-T201",
"O",
"B-T017",
"B-T037",
"O",
"O",
"B-T103",
"O",
"O",
"O",
"O",
"B-T038",
"O",
"B-T038",
"O",
... | [
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0035648",
"db_name": "UMLS"
},
{
"db_id": "C0035648",
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{
"db_id": null,
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{
"db_id": null,
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{
"db_id... | [
"Prevalence",
"and",
"Risk",
"Factors",
"Associated",
"With",
"Hypertension",
"in",
"von",
"Willebrand",
"Disease",
"von",
"Willebrand",
"factor",
"(",
"VWF",
")",
"is",
"a",
"biomarker",
"for",
"endothelial",
"damage",
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"Increased",
"VWF",
"levels",
"are",
... | [
[
0,
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],
[
11,
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],
[
15,
19
],
[
20,
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],
[
28,
38
],
[
39,
43
],
[
44,
56
],
[
57,
59
],
[
60,
63
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[
64,
74
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[
75,
82
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[
83,
86
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[
87,
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[
... | Prevalence and Risk Factors Associated With Hypertension in von Willebrand Disease von Willebrand factor (VWF) is a biomarker for endothelial damage. Increased VWF levels are observed in hypertension (HTN) and disorders of endothelial dysfunction, for example, atherosclerotic heart disease (ASHD) and diabetes. Whether low VWF protects against HTN is unknown. To determine prevalence and risk factors for HTN in patients with von Willebrand disease (VWD), we conducted a cross-sectional analysis of discharge data from the National Inpatient Sample, 2009 to 2011. Group comparisons were performed by Rao-Scott χ(2) test. Odds of HTN and HTN outcomes in VWD were estimated by weighted multivariable logistic regression. The prevalence of hypertension in patients with VWD (N = 7556), 37.35%, was significantly lower than that in non-VWD patients (N = 19 918 970), 49.40%, P < .0001. Hypertension risk factors (hyperlipidemia, diabetes, smoking, hepatitis C, and HIV) and HTN outcomes (ASHD, myocardial infarction [MI], ischemic stroke, and renal failure) were less common in patients with VWD than in non-VWD patients, all P ≤ .0001. Patients with VWD were younger, 49.67 versus 57.30 years, Caucasian, 82.23% versus 68.35%, and female, 75.44% versus 59.61%, P < .0001. Patients with HTN were older, 67.55 versus 47.29 years, male, 45.99% versus 34.90%, and had more HTN risk factors and HTN outcomes than those without HTN, all P < .0001, including male and female subgroups, each P < .0001. The unadjusted odds of HTN in patients with VWD (odds ratio [OR] = 0.611, P < .0001) and of HTN outcomes in patients with VWD (ASHD, OR = 0.509; MI, OR = 0.422; ischemic stroke, OR = 0.521; renal failure, OR = 0.420, all P < .0001) became insignificant after adjustment for HTN risk factors plus demographics (age / race / gender), OR = 1.035, P = .260. The risk of HTN is reduced in patients with VWD, but not after adjustment for HTN risk factors plus demographics, as patients with VWD not having HTN are also typically young, Caucasian, and female. |
[
"B-T103",
"I-T103",
"I-T103",
"O",
"B-T038",
"I-T038",
"O",
"O",
"B-T017",
"I-T017",
"O",
"O",
"O",
"O",
"B-T204",
"O",
"B-T204",
"O",
"O",
"B-T017",
"I-T017",
"I-T017",
"O",
"B-T017",
"O",
"O",
"O",
"O",
"B-T017",
"I-T017",
"O",
"O",
"O",
"B-T017",
... | [
{
"db_id": "C3661314",
"db_name": "UMLS"
},
{
"db_id": "C3661314",
"db_name": "UMLS"
},
{
"db_id": "C3661314",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C3494456",
"db_name": "UMLS"
},
{
"db_id": "C3494456",
"db_name": "U... | [
"miR",
"-",
"125b",
"affects",
"mitochondrial",
"biogenesis",
"and",
"impairs",
"brite",
"adipocyte",
"formation",
"and",
"function",
"In",
"rodents",
"and",
"humans",
",",
"besides",
"brown",
"adipose",
"tissue",
"(",
"BAT",
")",
",",
"islands",
"of",
"thermo... | [
[
0,
3
],
[
3,
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[
4,
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[
9,
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[
17,
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[
31,
41
],
[
42,
45
],
[
46,
53
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[
54,
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[
60,
69
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[
70,
79
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[
80,
83
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[
84,
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[
93,
... | miR-125b affects mitochondrial biogenesis and impairs brite adipocyte formation and function In rodents and humans, besides brown adipose tissue (BAT), islands of thermogenic adipocytes, termed " brite " (brown-in-white) or beige adipocytes, emerge within white adipose tissue (WAT) after cold exposure or β3-adrenoceptor stimulation, which may protect from obesity and associated diseases. microRNAs are novel modulators of adipose tissue development and function. The purpose of this work was to characterize the role of microRNAs in the control of brite adipocyte formation. Using human multipotent adipose derived stem cells, we identified miR-125b-5p as downregulated upon brite adipocyte formation. In humans and rodents, miR-125b-5p expression was lower in BAT than in WAT. In vitro, overexpression and knockdown of miR-125b-5p decreased and increased mitochondrial biogenesis, respectively. In vivo, miR-125b-5p levels were downregulated in subcutaneous WAT and interscapular BAT upon β3-adrenergic receptor stimulation. Injections of an miR-125b-5p mimic and LNA inhibitor directly into WAT inhibited and increased β3-adrenoceptor-mediated induction of UCP1, respectively, and mitochondrial brite adipocyte marker expression and mitochondriogenesis. Collectively, our results demonstrate that miR-125b-5p plays an important role in the repression of brite adipocyte function by modulating oxygen consumption and mitochondrial gene expression. |
[
"B-T058",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T017",
"B-T017",
"I-T017",
"O",
"O",
"B-T082",
"O",
"B-T017",
"I-T017",
"I-T017",
"O",
"O",
"O",
"B-T017",
"I-T017",
"I-T017",
"O",
"B-T017",
"O",
"O",
"O",
"O",
"B-T033",
"I-T033",
"O",
"B-T058"... | [
{
"db_id": "C0220825",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
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},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,... | [
"Evaluation",
"of",
"Outcome",
"Following",
"Coronectomy",
"for",
"the",
"Management",
"of",
"Mandibular",
"Third",
"Molars",
"in",
"Close",
"Proximity",
"to",
"Inferior",
"Alveolar",
"Nerve",
"Iatrogenic",
"damage",
"to",
"Inferior",
"Alveolar",
"Nerve",
"(",
"IA... | [
[
0,
10
],
[
11,
13
],
[
14,
21
],
[
22,
31
],
[
32,
43
],
[
44,
47
],
[
48,
51
],
[
52,
62
],
[
63,
65
],
[
66,
76
],
[
77,
82
],
[
83,
89
],
[
90,
92
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[
... | Evaluation of Outcome Following Coronectomy for the Management of Mandibular Third Molars in Close Proximity to Inferior Alveolar Nerve Iatrogenic damage to Inferior Alveolar Nerve (IAN) is a significant risk factor following prophylactic or therapeutic removal of impacted mandibular third molar. The risk to IAN injury increases many fold, when the third molar root overlaps the nerve canal as identified by the radiographic imaging. Various methods like orthodontic assisted extraction, staged removal of tooth or coronectomy have been advocated to reduce the incidence of IAN injury in high risk cases with variable outcome. The aim of present study was to evaluate the fate of the root (resorbed, exfoliated, covered by bone) after coronectomy or intentional root retention of impacted mandibular 3(rd) molars in patients with high risk for inferior alveolar nerve damage as evaluated by the intra oral periapical radiograph. Twenty impacted mandibular third molar teeth, in 18 patients with high risk of injury to IAN based on Rood's Criteria in an intra oral periapical radiographic examination, between the age group of 18 to 40 years, were included in the study. Preoperatively the impacted third molars were evaluated clinically as well as radiographically. Pederson Difficulty Index and Winter's Classification of impacted tooth was recorded. Coronectomy was done at the cemento enamel junction leaving the roots 2-3mm below the alveolar crest and primary closure was done. Patients were evaluated periodically for two years at six months interval. Post operative pain, swelling, IAN injury or any other complications were observed and recorded. None of the patients had IAN injury and none required second surgical removal. There was no incidence of post-operative infection and none required second surgical intervention. However, two of our patients had failed coronectomy (10%) due to mobilization of roots intra operatively and the roots were removed. One patient developed profuse bleeding intra-operatively in the failed coronectomy case. One patient had temporary lingual nerve paresthesia. Coronectomy procedure is effective in controlling inferior alveolar nerve injury following third molar surgery, in radiographically evaluated high risk cases and it has very low incidence of complications. |
[
"O",
"B-T038",
"O",
"B-T038",
"I-T038",
"I-T038",
"I-T038",
"O",
"O",
"O",
"B-T082",
"B-T103",
"O",
"O",
"O",
"O",
"O",
"B-T038",
"O",
"O",
"O",
"O",
"B-T058",
"I-T058",
"B-T103",
"O",
"O",
"O",
"B-T103",
"O",
"O",
"O",
"B-T038",
"I-T038",
"O",
"... | [
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0031099",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0011860",
"db_name": "UMLS"
},
{
"db_id": "C0011860",
"db_name": "UMLS"
},
{
"db_id": "C0011860",
"db_name": "UMLS"
}... | [
"Interlinking",
"Periodontitis",
"and",
"Type",
"2",
"Diabetes",
"Mellitus",
"by",
"Assessment",
"of",
"Crevicular",
"Visfatin",
"Levels",
"in",
"Health",
"and",
"in",
"Disease",
"Before",
"and",
"After",
"Initial",
"Periodontal",
"Therapy",
"Visfatin",
"is",
"a",... | [
[
0,
12
],
[
13,
26
],
[
27,
30
],
[
31,
35
],
[
36,
37
],
[
38,
46
],
[
47,
55
],
[
56,
58
],
[
59,
69
],
[
70,
72
],
[
73,
83
],
[
84,
92
],
[
93,
99
],
[
... | Interlinking Periodontitis and Type 2 Diabetes Mellitus by Assessment of Crevicular Visfatin Levels in Health and in Disease Before and After Initial Periodontal Therapy Visfatin is a new adipocytokine associated with both chronic periodontitis and type 2 diabetes mellitus independently. We aimed to estimate and compare the changes in the levels of visfatin in the Gingival Crevicular Fluid (GCF) of healthy subjects and in subjects with periodontitis with or without controlled Type 2 Diabetes Mellitus (T2DM) after administration of non-surgical periodontal therapy. Forty two subjects were equally divided into Group 1 (healthy), Group 2 (systemically healthy with chronic periodontitis), Group 3 (subjects with chronic periodontitis having controlled T2DM). Defined clinical parameters were recorded at baseline and at one month follow-up period. Visfatin was assessed using enzyme linked immunosorbent assay. One way ANOVA and Tukey's multiple post hoc procedures were used. Pearson's correlation coefficient was used for correlation. Significant increase in the visfatin levels was seen with the highest values observed in diabetes with periodontal disease. Visfatin responded to non-surgical periodontal therapy as observed by significant decrease in levels after one month but even at this period diabetics showed the highest levels. Visfatin levels are highest in individuals with both periodontal disease and diabetes even after periodontal therapy. Individuals with T2DM may be at higher risk of developing periodontal disease. |
[
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T033",
"I-T033",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T098",
"O",
"B-T038",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T082",
"O",
"B-T062",
"O",
"O",
"O",
"B-T058",
"O",
"O",
"O",
"B-T033"... | [
{
"db_id": null,
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{
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},
{
"db_id": null,
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},
{
"db_id": null,
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},
{
"db_id": null,
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},
{
"db_id": null,
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},
{
"db_id": null,
"db... | [
"Effects",
"of",
"Rational",
"-",
"Emotive",
"Hospice",
"Care",
"Therapy",
"on",
"Problematic",
"Assumptions",
",",
"Death",
"Anxiety",
",",
"and",
"Psychological",
"Distress",
"in",
"a",
"Sample",
"of",
"Cancer",
"Patients",
"and",
"Their",
"Family",
"Caregiver... | [
[
0,
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],
[
8,
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],
[
11,
19
],
[
19,
20
],
[
20,
27
],
[
28,
35
],
[
36,
40
],
[
41,
48
],
[
49,
51
],
[
52,
63
],
[
64,
75
],
[
75,
76
],
[
77,
82
],
[
8... | Effects of Rational-Emotive Hospice Care Therapy on Problematic Assumptions, Death Anxiety, and Psychological Distress in a Sample of Cancer Patients and Their Family Caregivers in Nigeria This study was a preliminary investigation that aimed to examine the effects of rational emotive hospice care therapy (REHCT) on problematic assumptions, death anxiety, and psychological distress in a sample of cancer patients and their family caregivers in Nigeria. The study adopted a pre-posttest randomized control group design. Participants were community-dwelling cancer patients (n = 32) and their family caregivers (n = 52). The treatment process consisted of 10 weeks of full intervention and 4 weeks of follow-up meetings that marked the end of intervention. The study used repeated-measures analysis of variance for data analysis. The findings revealed significant effects of a REHCT intervention program on problematic assumptions, death anxiety, and psychological distress reduction among the cancer patients and their family caregivers at the end of the intervention. The improvements were also maintained at follow-up meetings in the treatment group compared with the control group who received the usual care and conventional counseling. The researchers have been able to show that REHCT intervention is more effective than a control therapy for cancer patients' care, education, and counseling in the Nigerian context. |
[
"O",
"O",
"B-T058",
"I-T058",
"I-T058",
"I-T058",
"I-T058",
"O",
"O",
"B-T082",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T103",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T098",
"O",
"B-T098",
"B-T058",
"I-T058",
"I-T058",
"I-T058",
"O",
"B-T058",
"O",
"O",
"... | [
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0452268",
"db_name": "UMLS"
},
{
"db_id": "C0452268",
"db_name": "UMLS"
},
{
"db_id": "C0452268",
"db_name": "UMLS"
},
{
"db_id": "C0452268",
"db_name": "UMLS"
}... | [
"Comparison",
"of",
"Very",
"Low",
"Energy",
"Diet",
"Products",
"Available",
"in",
"Australia",
"and",
"How",
"to",
"Tailor",
"Them",
"to",
"Optimise",
"Protein",
"Content",
"for",
"Younger",
"and",
"Older",
"Adult",
"Men",
"and",
"Women",
"Very",
"low",
"e... | [
[
0,
10
],
[
11,
13
],
[
14,
18
],
[
19,
22
],
[
23,
29
],
[
30,
34
],
[
35,
43
],
[
44,
53
],
[
54,
56
],
[
57,
66
],
[
67,
70
],
[
71,
74
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[
75,
77
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... | Comparison of Very Low Energy Diet Products Available in Australia and How to Tailor Them to Optimise Protein Content for Younger and Older Adult Men and Women Very low energy diets (VLED) are efficacious in inducing rapid weight loss but may not contain adequate macronutrients or micronutrients for individuals with varying nutritional requirements. Adequate protein intake during weight loss appears particularly important to help preserve fat free mass and control appetite, and low energy and carbohydrate content also contributes to appetite control. Therefore, the purpose of this study was to compare the nutritional content (with a focus on protein), nutritional adequacy and cost of all commercially-available VLED brands in Australia. Nutritional content and cost were extracted and compared between brands and to the Recommended Dietary Intake (RDI) or adequate intake (AI) of macronutrients and micronutrients for men and women aged 19-70 years or >70 years. There was wide variability in the nutritional content, nutritional adequacy and cost of VLED brands. Most notably, even brands with the highest daily protein content, based on consuming three products/day (KicStart™ and Optislim(®), ~60 g/day), only met estimated protein requirements of the smallest and youngest women for whom a VLED would be indicated. Considering multiple options to optimise protein content, we propose that adding pure powdered protein is the most suitable option because it minimizes additional energy, carbohydrate and cost of VLEDs. |
[
"B-T058",
"I-T058",
"I-T058",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T103",
"I-T103",
"O",
"O",
"B-T058",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T170",
"O",
"O",
"O",
"B-T103",
"I-T103",
"O",
"O",
"O",
"B-T017",
"O",
"O",
"O",
"O",
"O",
... | [
{
"db_id": "C0024485",
"db_name": "UMLS"
},
{
"db_id": "C0024485",
"db_name": "UMLS"
},
{
"db_id": "C0024485",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
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},
{
... | [
"Magnetic",
"Resonance",
"Imaging",
"Appearance",
"and",
"Mechanism",
"of",
"Action",
"of",
"Five",
"Hemostatic",
"Agents",
"Used",
"in",
"Neurosurgery",
"To",
"describe",
"the",
"magnetic",
"resonance",
"(",
"MR",
")",
"image",
"appearance",
"of",
"5",
"hemosta... | [
[
0,
8
],
[
9,
18
],
[
19,
26
],
[
27,
37
],
[
38,
41
],
[
42,
51
],
[
52,
54
],
[
55,
61
],
[
62,
64
],
[
65,
69
],
[
70,
80
],
[
81,
87
],
[
88,
92
],
[
9... | Magnetic Resonance Imaging Appearance and Mechanism of Action of Five Hemostatic Agents Used in Neurosurgery To describe the magnetic resonance (MR) image appearance of 5 hemostatic agents placed in the brain, and to review their clinical application. Descriptive ex vivo and in vivo study. Canine cadavers (n=4), client-owned dogs (n=4). Heads from 4 canine cadavers were used, each with 5 hemostatic agents placed in specific locations in the brain. Hemostatic agents were used in their native form in 2 cadaveric brains, and in 2 others the materials were saturated with fresh whole blood prior to placement to mimic application in a field of active hemorrhage. The heads underwent MR imaging and the images were reviewed. Postoperative MRI images from 4 dogs undergoing brain tumor resection were retrospectively reviewed and compared to the images from the cadavers. All clinical cases and cadaveric specimens underwent surgical closure prior to MR imaging including placement of titanium mesh over the craniotomy defect with a dural graft of porcine small intestinal submucosa (SIS) sealed with Tisseel (fibrin sealant). The SIS and Tisseel used in the dural graft were consistently indistinguishable from the surrounding tissues on MR images. The MR imaging appearance of the remaining 4 hemostatic agents (Gelfoam, Avitene, Surgicel, and Floseal) placed on the surface or in the parenchyma of canine brain, varied with MR sequence weighting and blood saturation. Accurate evaluation of the degree of brain tumor resection on postoperative MR images requires careful differentiation between hemorrhage, residual tumor, and hemostatic agents implanted. |
[
"B-T170",
"O",
"O",
"B-T201",
"I-T201",
"I-T201",
"O",
"B-T058",
"I-T058",
"I-T058",
"I-T058",
"I-T058",
"I-T058",
"I-T058",
"I-T058",
"I-T058",
"I-T058",
"I-T058",
"O",
"O",
"O",
"B-T038",
"I-T038",
"O",
"B-T038",
"O",
"O",
"O",
"B-T038",
"O",
"O",
"O",... | [
{
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"db_id": "C1997183",
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{
"db_id": "C1997183",
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{
"db_id": "C1997183",
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}... | [
"Prognostic",
"significance",
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79,
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... | Prognostic significance of blood pressure response during vasodilator stress Rb-82 positron emission tomography myocardial perfusion imaging A drop in blood pressure (BP) or blunted BP response is an established high-risk marker during exercise myocardial perfusion imaging (MPI); however, data are sparse regarding the prognostic value of BP response in patients undergoing vasodilator stress rubidium-82 (Rb-82) Positron Emission Tomography (PET) MPI. From the PET Prognosis Multicenter Registry, a cohort of 3413 patients underwent vasodilator stress Rb-82 PET MPI with dipyridamole or adenosine. We used multivariable Cox proportional hazard regression to analyze the association with mortality of four BP variables: stress minus rest systolic BP (∆SBP), stress minus rest diastolic BP (∆DBP), resting systolic BP (rSBP), and resting diastolic BP (rDBP). Covariates that had univariate P values <.10 were entered into the multivariable model. After median 1.7 years follow-up, 270 patients died. In univariate analyses, ∆SBP (P = .082), rSBP (P = .008), and rDBP (P < .001) were of potential prognostic value (P < .10), but ∆DBP was not (P = .96). After adjustment for other clinical and MPI variables, ∆SBP no longer independently predicted mortality (P = .082); only lower rSBP (P = .026) and lower rDBP (P = .045) remained independently prognostic. In patients undergoing vasodilator stress MPI, only lower resting BP is an independent predictor of mortality along with other clinical and MPI variables; BP response does not appear to add to risk stratification in these patients. |
[
"B-T103",
"I-T103",
"O",
"O",
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"I-T103",
"I-T103",
"B-T103",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T033",
"I-T033",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T103",
"O",
"O",
"O",
"O",
"O",
"B-T033",
"O",
"B-T033",
"O",
"O",
"O",
"O... | [
{
"db_id": "C1138408",
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},
{
"db_id": "C1138408",
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{
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{
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{
"db_id": "C1258487",
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{
"db_id": "C1258487",
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}... | [
"Carbon",
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17,
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23,
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27,
28
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[
28,
36
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[
37,
44
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[
45,
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[
56,
59
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69,
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73,
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7... | Carbon nanotube -based self-adhesive polymer electrodes for wireless long-term recording of electrocardiogram signals In this study, the concept of polymer electrodes integrated with a wireless electrocardiogram (ECG) system was described. Polymer electrodes for long-term ECG measurements were fabricated by loading high content of carbon nanotubes (CNTs) in polydimethylsiloxane. Silver nanoparticles (Ag NPs) were added to increase the flexibility of the polymer and the conductivity of the electrode. An ECG electrode patch was fabricated by integrating the electrodes with an adhesive polydimethylsiloxane (aPDMS) layer. Holes in the electrode filled with aPDMS can enable robust contact between the electrode and skin, reducing motion artifacts. A wireless ECG measurement system was developed and adapted to the polymer electrodes. The polymer electrodes combined with the measurement system were successfully applied in wireless, long-term recording of ECG signals. An eleven- day continuous test showed that the ECG signal did not degrade over time. The results of attach/detach tests demonstrated that the ECG signal was affected by motion artifacts after six attach/detach cycles. The electrodes produced are flexible and exhibit good ECG performance, and therefore can be used in wearable medical monitoring systems. The approach proposed in this study holds significant promise for commercial application in medical fields. |
[
"O",
"B-T038",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T062",
"O",
"O",
"O",
"B-T038",
"O",
"O",
"B-T038",
"I-T038",
"B-T033",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
... | [
{
"db_id": null,
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{
"db_id": "C0424295",
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{
"db_id": null,
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{
"db_id": null,
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{
"db_id": null,
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{
"db_id": null,... | [
"Childhood",
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"problems",
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45,
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48,
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49,
53
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53,
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55,
63
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64,
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69,
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... | Childhood hyperactivity and mood problems at mid-life: evidence from a prospective birth cohort Childhood hyperactivity leads to mental health problems, but it is not known whether there are long-term risks for adult mood problems in unselected population cohorts that extend to mid-life. Aims were to examine links between childhood hyperactivity and mood problems up to age 50 years and to consider confounding factors and gender differences in associations. The National Child Development Study (NCDS) is a UK cohort of children born in 1958. Children with (N = 453) and without (N = 9192) pervasive and persistent hyperactivity were followed to age 50. Adult mood was assessed using the Malaise Inventory at ages 23, 33, 42, and 50 years and the CIS-R interview at 45 years. Childhood hyperactivity predicted low mood at all adult assessments (ES = 0.27-0.45), including after covariate adjustment (childhood adversity, emotional and behavioural problems, and attainment). Hyperactivity has enduring risk effects on low mood throughout the life course that extend to middle age. |
[
"O",
"O",
"O",
"O",
"B-T103",
"I-T103",
"O",
"B-T038",
"B-T037",
"I-T037",
"O",
"O",
"O",
"B-T170",
"I-T170",
"B-T170",
"B-T037",
"O",
"O",
"O",
"O",
"O",
"B-T033",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T038",
"O... | [
{
"db_id": null,
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{
"db_id": null,
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{
"db_id": null,
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},
{
"db_id": "C0040613",
"db_name": "UMLS"
},
{
"db_id": "C0040613",
"db_name": "UMLS"
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{
"db_id... | [
"Safety",
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"efficacy",
"of",
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"acid",
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"bleeding",
"paediatric",
"trauma",
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"leading",
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"among",
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... | [
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0,
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11,
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[
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34,
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39,
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42,
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69,
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8... | Safety and efficacy of tranexamic acid in bleeding paediatric trauma patients: a systematic review protocol Trauma is the leading cause of death among children aged 1-18. Studies indicate that better control of bleeding could potentially prevent 10-20% of trauma -related deaths. The antifibrinolytic agent tranexamic acid (TxA) has shown promise in haemorrhage control in adult trauma patients. However, information on the potential benefits of TxA in children remains sparse. This review proposes to evaluate the current uses, benefits and adverse effects of TxA in the bleeding paediatric trauma population. A structured search of bibliographic databases (eg, MEDLINE, EMBASE, PubMed, CINAHL, Cochrane CENTRAL) has been undertaken to retrieve randomised controlled trials and cohort studies that describe the use of TxA in paediatric trauma patients. To ensure that all relevant data were captured, the search did not contain any restrictions on language or publication time. After deduplication, citations will be screened independently by 2 authors, and selected for inclusion based on prespecified criteria. Data extraction and risk of bias assessment will be performed independently and in duplicate. Meta-analytic methods will be employed wherever appropriate. This study will not involve primary data collection, and formal ethical approval will therefore not be required. The findings of this study will be disseminated through a peer-reviewed publication and at relevant conference meetings. CRD42016038023. |
[
"B-T058",
"O",
"B-T038",
"I-T038",
"O",
"O",
"O",
"O",
"O",
"B-T170",
"O",
"O",
"O",
"O",
"B-T092",
"I-T092",
"I-T092",
"I-T092",
"O",
"B-T058",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T038",
"I-T038",
"O",
"B-T038",
"O",
"O",
"O",
"O",
"O",
"B-T062",
... | [
{
"db_id": "C0040071",
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{
"db_id": null,
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},
{
"db_id": "C0026896",
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{
"db_id": "C0026896",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
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},
{
... | [
"Thymectomy",
"for",
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"Gravis",
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"A",
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... | [
[
0,
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11,
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[
15,
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26,
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32,
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[
34,
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[
36,
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[
38,
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[
40,
44
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[
45,
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[
52,
54
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[
55,
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61,
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... | Thymectomy for Myasthenia Gravis: A 10- year Review of Cases at the Hospital Universiti Sains Malaysia A thymectomy is considered effective for patients with myasthenia gravis (MG). Although a few studies have described the role of a thymectomy in the treatment of MG in Asians countries, there are no published data on the application of this surgical approach for MG in Malaysia. We aimed to describe the clinical outcomes of MG patients who underwent a thymectomy and the factors affecting these outcomes. This was a retrospective study involving 16 patients with MG who underwent a thymectomy at the Hospital Universiti Sains Malaysia (HUSM) from January 2002 until December 2012, with a follow-up period ranging from 3-120 months. The study consisted of 16 patients aged 22-78 years, 10 of whom were males. The overall remission / improvement rate was 87.5%, and the rate of clinical outcomes classified as unchanged / worsened was 12.5%. Thymomamatous or non-thymomamatous MG, histology features, Osserman stage and the duration of follow-up were not significant prognostic factors. Post-operative mortality was 6.2% (1 of 16 patients died of septic shock). A thymectomy seems to be an effective treatment for MG, with low surgical morbidity. Patients with a lower Osserman stage and those with/without thymomas had favourable outcomes. |
[
"B-T201",
"O",
"B-T038",
"I-T038",
"O",
"B-T201",
"I-T201",
"I-T201",
"I-T201",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T098",
"I-T098",
"O",
"O",
"O",
"B-T098",
"I-T098",
"O",
"O",
"O",
"B-T033",
"I-T033",
"O",
"O",
"B-T033",
"O",
"B-T038",
"O",
"O"... | [
{
"db_id": "C1305855",
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},
{
"db_id": null,
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},
{
"db_id": "C0005891",
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{
"db_id": "C0005891",
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},
{
"db_id": null,
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},
{
"db_id": "C2984554",
"db_name": "UMLS"
}... | [
"BMI",
",",
"Body",
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",",
"Emotional",
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[
0,
3
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[
3,
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[
5,
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[
10,
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[
15,
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[
17,
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[
27,
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[
31,
32
],
[
32,
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[
38,
41
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[
42,
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[
48,
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[
49,
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57,
... | BMI, Body Image, Emotional Well-Being and Weight-Control Behaviors in Urban African American Adolescents While urban African American adolescents face significant health disparities associated with overweight and obesity that follow them into adulthood; there is limited data on body image, emotional well-being, and weight control behaviors in this population to design effective public health interventions. This study was designed to understand the association of weight status to adolescent weight control, body image, and emotional well-being responses, in African American high school students. The study cohort consisted of 776 students, mean age 15.8 years (±1.2). Data from Guidelines for Adolescent Preventive Services (GAPS) student surveys and anthropometric studies were collected at School-Based Health Centers. Associations between adolescent responses on the GAPS and body mass index (BMI) status (healthy weight: 5th to less than 85th percentile, overweight: 85th to less than 95th percentile, obese: 95th percentile or greater) were estimated using logistic regression and dose- response plots. There were statistically significant associations between BMI category and weight control (ranging from a mean 5.18 to 7.68 odds of obesity) and body image (3.40 to 13.26 odds of obesity) responses. Responses to weight control and body image questions exhibited a dose-response for odds of overweight and obesity. Feelings of depressed mood were associated with obesity (1.47 times the odds of obesity compared to students who did not endorse depressed mood; 95% CI, 1.01 to 2.13) but not overweight status. Overweight and obese urban African American adolescents are more likely to screen positively on weight control risk behaviors and negative body image questions than their normal weight peers. The weight control and body image measures on the GAPS may provide information to identify youth in need of services and those motivated for brief school-based weight control interventions. |
[
"O",
"O",
"O",
"O",
"O",
"B-T103",
"B-T103",
"O",
"B-T103",
"O",
"B-T204",
"I-T204",
"B-T204",
"I-T204",
"O",
"O",
"O",
"B-T204",
"O",
"O",
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"O",
"O",
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"O",
"B-T204",
"O",
"O",
"O",
"B-T038",
"I-T038",
"O",
"O",
"O",
"O",
"O",
... | [
{
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{
"db_id": "C0073020",
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{
"db_id": "C003... | [
"In",
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"of",
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[
0,
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[
3,
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40,
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48,
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92... | In silico data analyses of recombinases GdDMC1A and GdDMC1B from Giardia duodenalis Giardia duodenalis is a worldwide protozoa known causing diarrhea in all vertebrates, humans among these. Homologous recombination is a mechanism that provides genomic stability. Two putative recombinases were identified in G. duodenalis genome: GdDMC1A and GdDMC1B. In this article, we describe the identification of conserved domains in GdDMC1A and GdDMC1B, such as: DNA binding domains (Helix-turn-helix motif, loops 1 and 2) and an ATPcap and Walker A and B motifs associated with ATP binding and hydrolysis, phylogenetic analyses among assemblages and three-dimensional structure modeling of these recombinases using bioinformatics tools. Also, experimental data is described about LD50 determination for ionizing radiation in trophozoites of G. duodenalis. Additionally, as recombinases, GdDMC1A and GdDMC1B were used to rescue a defective Saccharomyces cerevisiae Δ rad51 strain under genotoxic conditions and data is described. The data described here are related to the research article entitled " Characterization of recombinase DMC1B and its functional role as Rad51 in DNA damage repair in Giardia duodenalis trophozoites " (Torres-Huerta et al.,) [1]. |
[
"B-T103",
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"I-T038",
"I-T038",
"O",
"O",
"O",
"O",
"O",
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"O",
"O",
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"O",
"O",
"O",
"O",
"B-T062",
"I-T062",
"O",
"O",
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"O",
"O",
"O",
"B-T038",
"I-T038",
"I-T038",
"O",
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{
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{
"db_id": "C1561643",
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{
"db_id": "C1561643",
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},
{
"db_id": "C1561643",
"db_name": "UMLS"
},
{
"db_id": null,
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}... | [
"Statins",
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... | [
[
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[
35,
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[
40,
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[
44,
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[
49,
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53,
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56,
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60,
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6... | Statins in Chronic Kidney Disease: When and When Not to Use Them This supplement reviews the evidence from clinical trials for the appropriate use of statins in patients with Chronic kidney disease (CKD). |
[
"B-T170",
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"B-T091",
"O",
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"B-T058",
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"I-T058",
"I-T058",
"O",
"O",
"O",
"O",
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"B-T058",
"I-T058",
"I-T058",
"O",
"O",
"O",
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"O",
"O",
"O",
"O",
"O",
"O",
"B-T058",
"I-T058",
"I-T058",
"I-T058",
"I-T058"... | [
{
"db_id": "C2964659",
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{
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{
"db_id": "C0029355",
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{
"db_id": "C4277735",
"db_name": "UMLS"
},
{
... | [
"PROMIS",
"for",
"Orthopaedic",
"Outcomes",
"Measurement",
"Patient",
"-",
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"outcome",
"measures",
"have",
"become",
"important",
"tools",
"for",
"assessing",
"health",
"status",
"in",
"a",
"variety",
"of",
"patient",
"populations",
".",
"Many",
"histor... | [
[
0,
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[
7,
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],
[
11,
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],
[
23,
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],
[
32,
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44,
51
],
[
51,
52
],
[
52,
60
],
[
61,
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[
69,
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[
78,
82
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[
83,
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[
90,
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[
1... | PROMIS for Orthopaedic Outcomes Measurement Patient-reported outcome measures have become important tools for assessing health status in a variety of patient populations. Many historically or commonly used patient-reported outcome measures in orthopaedics are narrow in scope and are limited by the burden associated with their administration, making them useful only for specific populations. The Patient-Reported Outcomes Measurement Information System (PROMIS) was developed to overcome these limitations. The system was developed using item response theory, which allows for reliable and efficient estimation of underlying health traits using targeted item banks to assess physical function in the upper and lower extremities. PROMIS has been validated in patient populations with orthopaedic disorders of the foot and ankle, upper extremity, and spine and has demonstrated a marked improvement in measurement characteristics and reduced patient and administrative burden. PROMIS Physical Function measures are useful for assessing orthopaedic outcomes and are superior to legacy measures in several key populations. |
[
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T017",
"I-T017",
"I-T017",
"I-T017",
"O",
"O",
"B-T017",
"I-T017",
"I-T017",
"I-T017",
"O",
"B-T017",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T017",
"I-T017",
"O",
"O",
"O",
"B-T201",
"I-T... | [
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
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},
{
"db_id": null,
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{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db... | [
"Effect",
"of",
"Genotype",
"and",
"Previous",
"GH",
"Treatment",
"on",
"Adiposity",
"in",
"Adults",
"With",
"Prader",
"-",
"Willi",
"Syndrome",
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"with",
"Prader",
"-",
"Willi",
"syndrome",
"(",
"PWS",
")",
"have",
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"increased",
"proportion",
"... | [
[
0,
6
],
[
7,
9
],
[
10,
18
],
[
19,
22
],
[
23,
31
],
[
32,
34
],
[
35,
44
],
[
45,
47
],
[
48,
57
],
[
58,
60
],
[
61,
67
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[
68,
72
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[
73,
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[
79... | Effect of Genotype and Previous GH Treatment on Adiposity in Adults With Prader-Willi Syndrome Adults with Prader-Willi syndrome (PWS) have an increased proportion of sc fat mass compared with body mass index (BMI)-matched controls, but whether the genotype influences body composition and metabolic profile remains controversial. To assess body composition and metabolic features in adults with PWS, according to genetic subtype. In addition, the effect of previous GH treatment was assessed. Main Outcomes and Measures: Body composition (Dual Energy X-ray Absorptiometry) and metabolic parameters were compared in PWS adults (mean age, 25.5 ± 8.9 y) with deletion (n = 47) or uniparental disomy (UPD) (n = 26), taking into account GH treatment in childhood and/or adolescence. In subgroups, adipocyte size, fasting total ghrelin levels, and resting energy expenditure were measured, and hyperphagia was assessed by the Dykens Hyperphagia Questionnaire. In the whole sample, the deletion group had a higher BMI compared with UPD (40.9 ± 11.5 vs 34.6 ± 9.6 kg/m(2), P = .02), but there was no difference between groups in percent body fat, metabolic profile, adipocyte size, resting energy expenditure, hyperphagia score, or ghrelin levels. In subjects previously treated with GH, BMI was not different between UPD and deletion groups (33.0 ± 9.7 vs 33.5 ± 11.1 kg/m(2)). In addition, previous GH treatment was associated with decreased percent body fat and adipocyte volume only in the deletion group. A deletion genotype in adults with PWS is associated with increased BMI. GH treatment in childhood and/or adolescence limits this deleterious phenotypic effect with improved adiposity markers. This study suggests relationships between the molecular phenotype of PWS and adipose tissue development as well as sensitivity to GH. |
[
"B-T170",
"O",
"B-T062",
"I-T062",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T062",
"O",
"B-T062",
"O",
"B-T170",
"I-T170",
"I-T170",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T170",
"O",
"O",
"O",
"B-T170",
"O",
"O",
... | [
{
"db_id": "C0037589",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0936012",
"db_name": "UMLS"
},
{
"db_id": "C0936012",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
... | [
"Biospark",
":",
"scalable",
"analysis",
"of",
"large",
"numerical",
"datasets",
"from",
"biological",
"simulations",
"and",
"experiments",
"using",
"Hadoop",
"and",
"Spark",
"Data",
"-",
"parallel",
"programming",
"techniques",
"can",
"dramatically",
"decrease",
"t... | [
[
0,
8
],
[
8,
9
],
[
10,
18
],
[
19,
27
],
[
28,
30
],
[
31,
36
],
[
37,
46
],
[
47,
55
],
[
56,
60
],
[
61,
71
],
[
72,
83
],
[
84,
87
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[
88,
99
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[
10... | Biospark: scalable analysis of large numerical datasets from biological simulations and experiments using Hadoop and Spark Data-parallel programming techniques can dramatically decrease the time needed to analyze large datasets. While these methods have provided significant improvements for sequencing-based analyses, other areas of biological informatics have not yet adopted them. Here, we introduce Biospark, a new framework for performing data-parallel analysis on large numerical datasets. Biospark builds upon the open source Hadoop and Spark projects, bringing domain-specific features for biology. Source code is licensed under the Apache 2.0 open source license and is available at the project website: https://www.assembla.com/spaces/roberts-lab-public/wiki/Biospark CONTACT: eroberts@jhu.eduSupplementary information: Supplementary data are available at Bioinformatics online. |
[
"O",
"O",
"O",
"O",
"O",
"B-T082",
"I-T082",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T092",
"I-T092",
"I-T092",
"I-T092",
"O",
"B-T098",
"O",
"B-T091",
"I-T091",
"O",
"O",
"O",
"B-T033",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
... | [
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0442027",
"db_name": "UMLS"
},
{
"db_id": "C044... | [
"Evaluating",
"the",
"effectiveness",
"of",
"a",
"mock",
"oral",
"educational",
"program",
"To",
"obtain",
"board",
"certification",
",",
"the",
"American",
"Board",
"of",
"Surgery",
"requires",
"graduates",
"of",
"general",
"surgery",
"training",
"programs",
"to"... | [
[
0,
10
],
[
11,
14
],
[
15,
28
],
[
29,
31
],
[
32,
33
],
[
34,
38
],
[
39,
43
],
[
44,
55
],
[
56,
63
],
[
64,
66
],
[
67,
73
],
[
74,
79
],
[
80,
93
],
[
... | Evaluating the effectiveness of a mock oral educational program To obtain board certification, the American Board of Surgery requires graduates of general surgery training programs to pass both the written qualifying examination (QE) and the oral certifying examination (CE). In 2015, the pass rates for the QE and CE were 80% and 77%, respectively. In the 2011-2012 academic year, the University of Wisconsin instituted a mandatory, faculty-led, monthly CE preparation educational program (CE prep) as a supplement to their existing annual mock oral examination. We hypothesized that the implementation of these sessions would improve the first-time pass rate for residents taking the ABS CE at our institution. Secondary outcomes studied were QE pass rate, correlation with American Board of Surgery In-Training Examination (ABSITE) and mock oral examination scores, cost, and type of study materials used, perception of examination difficulty, and applicant preparedness. A sixteen question survey was sent to 57 of 59 residents who attended the University of Wisconsin between the years of 2007 and 2015. Email addresses for two former residents could not be located. De-identified data for the ABSITE and first-time pass rates for the QE and CE examination were retrospectively collected and analyzed along with survey results. Statistical analysis was performed using SPSS version 22 (IBM Corp., Armonk, NY). P values < 0.05 were considered significant. Survey response rate was 77.2%. Of the residents who have attempted the CE, first-time pass rate was 76.0% (19 of 25) before the implementation of the formal CE Prep and 100% (22 of 22) after (P = 0.025). Absolute ABSITE score, and mock oral annual examination grades were significantly improved after the CE Prep was initiated (P values < 0.001 and 0.003, respectively), however, ABSITE percentile was not significantly different (P = 0.415). ABSITE raw score and percentile, as well as mock oral annual examination scores were significantly associated with passing the QE (0.032, 0.027, and 0.020, respectively), whereas mock oral annual examination scores alone were associated with passing the CE (P = 0.001). Survey results showed that residents perceived the CE to be easier than the annual mock oral after the institution of the CE prep course (P = 0.036), however, there was no difference in their perception of preparedness. Overall, applicants felt extremely prepared for the CE (4.70 ± 0.5, Likert scale 1-5). Formal educational programs instituted during residency can improve resident performance on the ABS certifying examination. The institution of a formal, faculty-led monthly CE preparation educational program at the University of Wisconsin has significantly improved the first-time pass rate for the ABS CE. Mock oral annual examination scores were also significantly improved. Furthermore, ABSITE scores correlate with QE pass rates, and mock oral annual examination scores correlate with pass rates for both QE and CE. |
[
"O",
"B-T097",
"I-T097",
"B-T038",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T038",
"B-T058",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T097",
"I-T097",
"B-T038",
"I-T038",
"I-T038",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T058",
"I-T058",
"B-T058",
"O",
"O",
"O",
... | [
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0221460",
"db_name": "UMLS"
},
{
"db_id": "C0221460",
"db_name": "UMLS"
},
{
"db_id": "C0004271",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
... | [
"Using",
"farmers",
"'",
"attitude",
"and",
"social",
"pressures",
"to",
"design",
"voluntary",
"Bluetongue",
"vaccination",
"strategies",
"Understanding",
"the",
"context",
"and",
"drivers",
"of",
"farmers",
"'",
"decision",
"-",
"making",
"is",
"critical",
"to",... | [
[
0,
5
],
[
6,
13
],
[
13,
14
],
[
15,
23
],
[
24,
27
],
[
28,
34
],
[
35,
44
],
[
45,
47
],
[
48,
54
],
[
55,
64
],
[
65,
75
],
[
76,
87
],
[
88,
98
],
[
9... | Using farmers' attitude and social pressures to design voluntary Bluetongue vaccination strategies Understanding the context and drivers of farmers' decision-making is critical to designing successful voluntary disease control interventions. This study uses a questionnaire based on the Reasoned Action Approach framework to assess the determinants of farmers' intention to participate in a hypothetical reactive vaccination scheme against Bluetongue. Results suggest that farmers' attitude and social pressures best explained intention. A mix of policy instruments can be used in a complementary way to motivate voluntary vaccination based on the finding that participation is influenced by both internal and external motivation. Next to informational and incentive -based instruments, social pressures, which stem from different type of perceived norms, can spur farmers' vaccination behaviour and serve as catalysts in voluntary vaccination schemes. |
[
"B-T038",
"O",
"B-T038",
"O",
"O",
"B-T103",
"I-T103",
"I-T103",
"I-T103",
"O",
"O",
"B-T038",
"O",
"B-T204",
"O",
"B-T038",
"I-T038",
"B-T103",
"I-T103",
"I-T103",
"I-T103",
"O",
"B-T103",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T103",
"I-T103",
"I-T103... | [
{
"db_id": "C0949479",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C1514758",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0140057",
"db_name": "UMLS"
},
{
... | [
"Upregulation",
"and",
"activation",
"of",
"δ",
"‑",
"opioid",
"receptors",
"p",
"romotes",
"the",
"progression",
"of",
"human",
"b",
"reast",
"cancer",
"δ",
"‑",
"opioid",
"receptor",
"(",
"DOR",
")",
"belongs",
"to",
"the",
"family",
"of",
"G",
"protein"... | [
[
0,
12
],
[
13,
16
],
[
17,
27
],
[
28,
30
],
[
31,
32
],
[
33,
34
],
[
34,
40
],
[
41,
50
],
[
51,
52
],
[
53,
60
],
[
61,
64
],
[
65,
76
],
[
77,
79
],
[
... | Upregulation and activation of δ ‑opioid receptors p romotes the progression of human b reast cancer δ‑opioid receptor (DOR) belongs to the family of G protein‑coupled receptors (GPCRs). Numerous studies have shown that DOR is widely distributed in human peripheral tissues and is closely related to the development and progression of certain malignant tumours. However, there is controversy in the literature regarding whether DOR has an impact on the development and progression of human breast cancer. The present study comprehensively elaborates on the biological functions of DOR by determining the distribution of DOR expression in breast cancer tissues and cells and by further verifying the effects of DOR on breast cancer progression. DOR was found to be highly expressed in human breast cancer tissues and cells. In addition, the high expression level of DOR positively correlated with tumour grade and clinical stage and negatively correlated with breast cancer metastasis and prognosis. Upregulating and activating DOR promoted the proliferation of human breast cancer cells in a concentration‑dependent manner within a specific concentration range, whereas downregulating or inhibiting DOR activation significantly suppressed cell proliferation. The majority of tumour cells were arrested in G1 phase, and some cells exhibited apoptosis. DOR upregulation and activation induced protein kinase C (PKC) activation, resulting in increased phosphorylation levels of extracellular signal‑regulated kinases (ERKs). After inhibition of the P KC /ERK signalling pathway, the effects of DOR on breast cancer were significantly attenuated in vivo and in vitro. In summary, DOR is highly expressed in breast cancer and is closely related to its progression. These results suggest that DOR may serve as a potential biomarker for the early diagnosis of breast cancer and may be a viable molecular target for therapeutic intervention. |
[
"B-T103",
"I-T103",
"I-T103",
"O",
"O",
"B-T103",
"I-T103",
"I-T103",
"B-T017",
"I-T017",
"I-T017",
"O",
"O",
"B-T038",
"I-T038",
"I-T038",
"I-T038",
"I-T038",
"O",
"O",
"B-T033",
"I-T033",
"I-T033",
"I-T033",
"O",
"B-T103",
"I-T103",
"I-T103",
"B-T103",
"I-... | [
{
"db_id": "C3539881",
"db_name": "UMLS"
},
{
"db_id": "C3539881",
"db_name": "UMLS"
},
{
"db_id": "C3539881",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C1451170",
"db_name": "UMLS"
}... | [
"IFN",
"-",
"γ",
"-",
"producing",
"Th1",
"-",
"like",
"regulatory",
"T",
"cells",
"may",
"limit",
"acute",
"cellular",
"renal",
"allograft",
"rejection",
":",
"Paradoxical",
"post",
"-",
"transplantation",
"effects",
"of",
"IFN",
"-",
"γ",
"IFN",
"-",
"γ"... | [
[
0,
3
],
[
3,
4
],
[
4,
5
],
[
6,
7
],
[
7,
16
],
[
17,
20
],
[
20,
21
],
[
21,
25
],
[
26,
36
],
[
37,
38
],
[
39,
44
],
[
45,
48
],
[
49,
54
],
[
55,
... | IFN-γ -producing Th1-like regulatory T cells may limit acute cellular renal allograft rejection: Paradoxical post-transplantation effects of IFN-γ IFN-γ is a protypical proinflammatory cytokine that plays a central role in inflammation and acute graft rejection. Accumulating evidence indicates that IFN-γ can exert previously unexpected immunoregulatory activities. However, little is known about the role of IFN-γ secreted by Th1-like regulatory T cells in human kidney transplantation. To determine the function of IFN-γ in acute T cell-mediated renal allograft rejection (ACR), we examined serum cytokine expression profiles in ACR patients by human cytokine multiplex immunoassay and analyzed the cellular origins of IFN-γ in peripheral blood and renal allograft biopsies from ACR cases and controls by flow cytometry and immunohistochemistry, respectively. The results showed significant reduction in serum concentrations of Th1 -inducing cytokines IL-12p70 and IFN-γ as well as Th2 -related cytokine IL-4 in ACR patients compared with stable controls. However, levels of several Th1 -, Th2 - and Th17 -related cytokines, such as IL-2, TNF-α, TNF-β, IL-12 (p40), IL-10, IL-15, IL-17, IL-21, and IL-23, as well as the frequencies of Th1 and Th17 cell, did not differ between ACR cases and stable controls. Moreover, we found the levels of IFN-γ were correlated with those of the anti-inflammatory factor, IL-1 receptor antagonist (IL-1Ra) in ACR. Notably, the Th1-like Treg cell -to- Foxp3(-) Th1 cell ratio was significantly lower in ACR patients compared with that in stable controls. In graft biopsies from ACR patients, Treg cells and Th1-like Treg cells were less abundant than those without ACR. Our study indicates that IFN-γ secreted from Th1-like Treg cells negatively modulates ACR. |
[
"B-T170",
"O",
"O",
"O",
"O",
"B-T103",
"I-T103",
"I-T103",
"I-T103",
"I-T103",
"I-T103",
"O",
"O",
"B-T038",
"I-T038",
"B-T201",
"B-T103",
"I-T103",
"I-T103",
"I-T103",
"O",
"B-T103",
"O",
"O",
"O",
"O",
"B-T103",
"O",
"O",
"B-T038",
"I-T038",
"I-T038",... | [
{
"db_id": "C0220901",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
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},
{
"db_id": null,
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},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C4045550",
"db_name": "UMLS"
},
{
"db_id... | [
"Prognostic",
"and",
"therapeutic",
"value",
"of",
"mitochondrial",
"serine",
"hydroxyl",
"-",
"methyltransferase",
"2",
"as",
"a",
"breast",
"cancer",
"biomarker",
"Mitochondrial",
"serine",
"hydroxylmethyltransferase",
"2",
"(",
"SHMT2",
")",
"is",
"a",
"key",
"... | [
[
0,
10
],
[
11,
14
],
[
15,
26
],
[
27,
32
],
[
33,
35
],
[
36,
49
],
[
50,
56
],
[
57,
65
],
[
65,
66
],
[
66,
83
],
[
84,
85
],
[
86,
88
],
[
89,
90
],
[
... | Prognostic and therapeutic value of mitochondrial serine hydroxyl-methyltransferase 2 as a breast cancer biomarker Mitochondrial serine hydroxylmethyltransferase 2 (SHMT2) is a key enzyme in the serine/glycine synthesis pathway. SHMT2 has been implicated as a critical component for tumor cell survival. The aim of the present study was to evaluate the prognostic value and efficiency of SHMT2 as a biomarker in patients with breast cancer. Individual and pooled survival analyses were performed on five independent breast cancer microarray datasets. Gene signatures enriched by SHMT2 were also analyzed in these datasets. SHMT2 protein expression was detected using immunohistochemistry (IHC) assay in 128 breast cancer cases. Gene set enrichment analysis revealed that SHMT2 was significantly associated with gene signatures of mitochondrial module, cancer invasion, metastasis and poor survival among breast cancer patients (p<0.05). The clinical relevance of SHMT2 was validated on IHC data. The mitochondrial localization of SHMT2 protein was visualized on IHC staining. Independent and pooled analysis confirmed that SHMT2 expression was associated with breast cancer tumor aggressiveness (TNM staging and Elson grade) in a dose-dependent manner (p<0.05). The prognostic performance of SHMT2 mRNA was comparable to other gene signatures and proved superior to TNM staging. Further analysis results indicated that SHMT2 had better prognostic value for estrogen receptor (ER)-negative breast cancer patients, compared to ER-positive patients. In cases involving stage IIb breast cancer, chemotherapy significantly extended survival time among patients with high SHMT2 expression. These results indicate that SHMT2 may be a valuable prognostic biomarker in ER-negative breast cancer cases. Furthermore, SHMT2 may be a potential target for breast cancer treatment and drug discovery. |
[
"O",
"B-T058",
"I-T058",
"I-T058",
"I-T058",
"I-T058",
"I-T058",
"O",
"O",
"O",
"O",
"B-T058",
"I-T058",
"I-T058",
"I-T058",
"I-T058",
"I-T058",
"I-T058",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T092",
"O",
"O",
"B-T058",
"I-T058",
"I-T0... | [
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0085555",
"db_name": "UMLS"
},
{
"db_id": "C0085555",
"db_name": "UMLS"
},
{
"db_id": "C0085555",
"db_name": "UMLS"
},
{
"db_id": "C0085555",
"db_name": "UMLS"
},
{
"db_id": "C0085555",
"db_name": "U... | [
"Improving",
"end",
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"of",
"-",
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13,
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],
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14,
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],
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16,
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],
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17,
21
],
[
22,
26
],
[
27,
34
],
[
35,
42
],
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43,
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55,
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64,
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68,
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[
... | Improving end-of-life care through quality improvement Although end of life (EoL) care has been identified as an area for quality improvement in hospitals, the quality of care Canadian patients receive at the end of life is not well-evidenced. National statistics indicate that Canadians would prefer to die at home, yet more than 50% die in acute care hospital settings. Busy and often highly specialised acute care units may be perceived as a distressing place of death for both patients and their families. Furthermore, many clinicians are not trained in diagnosing imminent dying, managing symptoms at the end of life or supporting dying patients and their families. As such, to improve the experience of EoL care, a corporate, institution -wide strategy entitled the Quality Dying Initiative was introduced and implemented across a tertiary care academic teaching hospital. A primary focus of this initiative was the implementation of a comprehensive Comfort Measures Strategy. This strategy involved the development of an evidence-based order set, which included elements of symptom assessment and management, patient and family education, and spiritual and emotional support. Staff education and mentoring was also a critical element of the larger Comfort Measures Strategy, as well as an evaluative component. |
[
"O",
"O",
"O",
"O",
"B-T092",
"O",
"B-T170",
"O",
"O",
"O",
"O",
"B-T038",
"O",
"B-T033",
"O",
"O",
"B-T098",
"I-T098",
"O",
"O",
"O",
"B-T038",
"O",
"B-T062",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T092",
"O",
"B-T170",
"O",
"O",
"O",
"O",
... | [
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
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},
{
"db_id": "C0043237",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C170... | [
"The",
"value",
"of",
"counting",
"WHO",
"-",
"defined",
"cardiovascular",
"risk",
"factors",
"for",
"death",
"and",
"disability",
"in",
"a",
"national",
"sample",
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"adults",
"with",
"psychosis",
"This",
"study",
"explored",
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"prevalence",
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"a... | [
[
0,
3
],
[
4,
9
],
[
10,
12
],
[
13,
21
],
[
22,
25
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[
26,
27
],
[
28,
35
],
[
36,
50
],
[
51,
55
],
[
56,
63
],
[
64,
67
],
[
68,
73
],
[
74,
77
],
[
78... | The value of counting WHO - defined cardiovascular risk factors for death and disability in a national sample of adults with psychosis This study explored the prevalence and associations of eight WHO - defined CVD risk factors for death and disability in people with psychosis. The study included 1156 people aged 18-64years, diagnosed with psychosis. The 2009 World Health Organisation (WHO) Global Health Risks Report was used as a framework to determine the prevalence and number of eight key risk factors for cardiovascular disease (CVD) in men and women with psychosis. Differences in the number and type of risk factors by age and gender were investigated. Multi-predictor analysis was performed to identify associations between demographic factors, psychiatric diagnosis and accumulative CVD risk factors. Women had fewer CVD risk factors than men. The number of risk factors significantly decreased in association with single marital status, current employment and significantly increased with earning a higher income. People aged 35-49years and 50-64years had an average of 4 risk factors (SD 1.38 and 1.30); people aged 18-34years had an average of 3 risk factors (SD 1.30). Mean risk factors were higher in the middle age and older age groups (35-49years and 50-64years) compared with the younger age group (18-34years) (p<0.0001). Overweight/obesity, hypertension, high blood glucose / diabetes and high cholesterol were significantly more prevalent in older men and women. People with psychosis have a high prevalence of individual and aggregate CVD risks. These were more common in men and rose with age, implying the necessity of close clinical monitoring. The most common risk factors should be targeted by lifestyle interventions. |
[
"B-T103",
"O",
"B-T103",
"I-T103",
"O",
"B-T103",
"O",
"O",
"B-T038",
"I-T038",
"I-T038",
"O",
"B-T017",
"O",
"O",
"O",
"B-T103",
"O",
"B-T103",
"O",
"O",
"B-T103",
"B-T103",
"O",
"B-T103",
"B-T103",
"O",
"O",
"O",
"O",
"B-T204",
"B-T103",
"O",
"O",
... | [
{
"db_id": "C0390172",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0014442",
"db_name": "UMLS"
},
{
"db_id": "C0014442",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0079189",
"db_name": "UMLS"
}... | [
"Sakuranetin",
"Inhibits",
"Inflammatory",
"Enzyme",
",",
"Cytokine",
",",
"and",
"Costimulatory",
"Molecule",
"Expression",
"in",
"Macrophages",
"through",
"Modulation",
"of",
"JNK",
",",
"p38",
",",
"and",
"STAT1",
"Sakuranetin",
"is",
"flavonoid",
"phytoalexin",
... | [
[
0,
11
],
[
12,
20
],
[
21,
33
],
[
34,
40
],
[
40,
41
],
[
42,
50
],
[
50,
51
],
[
52,
55
],
[
56,
69
],
[
70,
78
],
[
79,
89
],
[
90,
92
],
[
93,
104
],
[
... | Sakuranetin Inhibits Inflammatory Enzyme, Cytokine, and Costimulatory Molecule Expression in Macrophages through Modulation of JNK, p38, and STAT1 Sakuranetin is flavonoid phytoalexin that serves as a plant antibiotic and exists in Prunus and several other plant species. Recently, we identified the anti-inflammatory effect of Prunus yedoensis and found that there were few studies on the potential anti-inflammatory activity of sakuranetin, one of the main constituents of Prunus yedoensis. Here, we isolated peritoneal macrophages from thioglycollate -injected mice and examined whether sakuranetin affected the response of the macrophages in response to lipopolysaccharide (LPS) plus interferon- (IFN-) γ or LPS only. Sakuranetin suppressed the synthesis of iNOS and COX2 in LPS / IFN-γ stimulated cells and the secretion of TNF-α, IL-6, and IL-12 in LPS stimulated cells. The surface expression of the costimulatory molecules, CD86 and CD40, was also decreased. Among the LPS -induced signaling molecules, STAT1, JNK, and p38 phosphorylation was attenuated. These findings are evidence that sakuranetin acts as anti-inflammatory flavonoid and further study is required to evaluate its in vivo efficacy. |
[
"O",
"B-T033",
"O",
"O",
"O",
"O",
"B-T038",
"I-T038",
"O",
"B-T038",
"O",
"O",
"O",
"O",
"B-T033",
"I-T033",
"I-T033",
"I-T033",
"I-T033",
"O",
"B-T033",
"O",
"O",
"O",
"O",
"B-T038",
"I-T038",
"O",
"B-T038",
"I-T038",
"I-T038",
"I-T038",
"O",
"O",
... | [
{
"db_id": null,
"db_name": null
},
{
"db_id": "C2936455",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C024... | [
"Serial",
"cVEMP",
"Testing",
"is",
"Sensitive",
"to",
"Disease",
"Progression",
"in",
"Ménière",
"Patients",
"To",
"assess",
"the",
"cervical",
"vestibular",
"evoked",
"myogenic",
"potentials",
"(",
"cVEMPs",
")",
"ability",
"to",
"track",
"disease",
"progression... | [
[
0,
6
],
[
7,
12
],
[
13,
20
],
[
21,
23
],
[
24,
33
],
[
34,
36
],
[
37,
44
],
[
45,
56
],
[
57,
59
],
[
60,
67
],
[
68,
76
],
[
77,
79
],
[
80,
86
],
[
8... | Serial cVEMP Testing is Sensitive to Disease Progression in Ménière Patients To assess the cervical vestibular evoked myogenic potentials (cVEMPs) ability to track disease progression in Ménière's disease patients over time and identify the most sensitive outcome measurement. Retrospective. Large specialty hospital, department of otolaryngology. Twenty nine Ménière's patients and seven migraine associated vertigo (MAV) patients. All patients underwent two cervical vestibular evoked myogenic potential tests at 250, 500, 750, and 1000 Hz with a minimum test interval of 3 months. Threshold, peak-to-peak (PP) amplitude, interaural asymmetry ratio, and effect size. In affected Ménière's ears all outcome measures were worse during the second test, for threshold this difference was statistically significant at 750 and 1000 Hz compared with the first test. Compared with young healthy ears the threshold was significantly worse at all frequencies. PP amplitude was significantly decreased at the second test at 750 Hz compared with the first test. In MAV no significant difference between tests was found at any frequency in PP amplitude or threshold. In Ménière's ears, threshold showed a higher first -to- second effect size at 500, 750, and 1000 Hz compared with PP amplitude. cVEMP is able to track progression in Ménière's disease over time. Thresholds were the most effective outcome measure to both track progression and to distinguish between MAV and Ménière's patients. |
[
"O",
"B-T062",
"I-T062",
"O",
"O",
"B-T058",
"I-T058",
"O",
"O",
"O",
"B-T058",
"B-T038",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T092",
"I-T092",
"I-T092",
"I-T092",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T038",
"O",
"B-T098",
"O",
"B-T058",
"O",
"O",
... | [
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0920631",
"db_name": "UMLS"
},
{
"db_id": "C0920631",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C1113679",
"db_name": "UMLS"
},
{
... | [
"A",
"Patient",
"Registry",
"to",
"Improve",
"Patient",
"Safety",
":",
"Recording",
"General",
"Neurosurgery",
"Complications",
"To",
"improve",
"the",
"transparency",
"of",
"the",
"local",
"health",
"care",
"system",
",",
"treatment",
"cost",
"was",
"recently",
... | [
[
0,
1
],
[
2,
9
],
[
10,
18
],
[
19,
21
],
[
22,
29
],
[
30,
37
],
[
38,
44
],
[
44,
45
],
[
46,
55
],
[
56,
63
],
[
64,
76
],
[
77,
90
],
[
91,
93
],
[
94... | A Patient Registry to Improve Patient Safety: Recording General Neurosurgery Complications To improve the transparency of the local health care system, treatment cost was recently referenced to disease related groups. Treatment quality must be legally documented in a patient registry, in particular for the highly specialized treatments provided by neurosurgery departments. In 2013 we have installed a patient registry focused on cranial neurosurgery. Surgeries are characterized by indication, treatment, location and other specific neurosurgical parameters. Preoperative state and postoperative outcome are recorded prospectively using neurological and sociological scales. Complications are graded by their severity in a therapy-oriented complication score system (Clavien-Dindo-Grading system, CDG). Results are presented at the monthly clinical staff meeting. Data acquisition compatible with the clinic workflow permitted to include all eligible patients into the registry. Until December 2015, we have registered 2880 patients that were treated in 3959 surgeries and 8528 consultations. Since the registry is fully operational (August 2014), we have registered 325 complications on 1341 patient discharge forms (24%). In 64% of these complications, no or only pharmacological treatment was required. At discharge, there was a clear correlation of the severity of the complication and the Karnofsky Performance Status (KPS, ρ = -0.3, slope -6 KPS percentage points per increment of CDG) and the length of stay (ρ = 0.4, slope 1.5 days per increment of CDG). While the therapy-oriented complication scores correlate reasonably well with outcome and length of stay, they do not account for new deficits that cannot be treated. Outcome grading and complication severity grading thus serve a complimentary purpose. Overall, the registry serves to streamline and to complete information flow in the clinic, to identify complication rates and trends early for the internal quality monitoring and communication with patients. Conversely, the registry influences clinical practice in that it demands rigorous documentation and standard operating procedures. |
[
"B-T017",
"O",
"B-T033",
"I-T033",
"I-T033",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T033",
"O",
"B-T038",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T082",
"O",
"B-T082",
"O",
"O",
"O",
"B-T058",
"I-T058",
"O",
"O",
"O",
"O",
"O",
... | [
{
"db_id": "C3146295",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0518023",
"db_name": "UMLS"
},
{
"db_id": "C0518023",
"db_name": "UMLS"
},
{
"db_id": "C0518023",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
}... | [
"Triceps",
"and",
"Subscapular",
"Skinfold",
"Thickness",
"Percentiles",
"and",
"Cut",
"-",
"Offs",
"for",
"Overweight",
"and",
"Obesity",
"in",
"a",
"Population",
"-",
"Based",
"Sample",
"of",
"Schoolchildren",
"and",
"Adolescents",
"in",
"Bogota",
",",
"Colomb... | [
[
0,
7
],
[
8,
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],
[
12,
23
],
[
24,
32
],
[
33,
42
],
[
43,
54
],
[
55,
58
],
[
59,
62
],
[
62,
63
],
[
63,
67
],
[
68,
71
],
[
72,
82
],
[
83,
86
],
[
8... | Triceps and Subscapular Skinfold Thickness Percentiles and Cut-Offs for Overweight and Obesity in a Population-Based Sample of Schoolchildren and Adolescents in Bogota, Colombia The assessment of skinfold thickness is an objective measure of adiposity. The aims of this study were to establish Colombian smoothed centile charts and LMS L (Box-Cox transformation), M (median), and S (coefficient of variation) tables for triceps, subscapular, and triceps + subscapular skinfolds; appropriate cut-offs were selected using receiver operating characteristic (ROC) analysis based on a population-based sample of children and adolescents in Bogotá, Colombia. A cross-sectional study was conducted in 9618 children and adolescents (55.7% girls; age range of 9-17.9 years). Triceps and subscapular skinfold measurements were obtained using standardized methods. We calculated the triceps + subscapular skinfold (T + SS) sum. Smoothed percentile curves for triceps and subscapular skinfold thickness were derived using the LMS method. ROC curve analyses were used to evaluate the optimal cut-off point of skinfold thickness for overweight and obesity, based on the International Obesity Task Force definitions. Subscapular and triceps skinfolds and T + SS were significantly higher in girls than in boys (p < 0.001). The ROC analysis showed that subscapular and triceps skinfolds and T + SS have a high discriminatory power in the identification of overweight and obesity in the sample population in this study. Our results provide sex - and age -specific normative reference standards for skinfold thickness values from a population from Bogotá, Colombia. |
[
"O",
"O",
"O",
"B-T204",
"I-T204",
"I-T204",
"I-T204",
"O",
"B-T204",
"I-T204",
"O",
"B-T038",
"O",
"O",
"B-T038",
"I-T038",
"O",
"B-T038",
"I-T038",
"O",
"B-T204",
"I-T204",
"O",
"O",
"O",
"O",
"O",
"B-T103",
"I-T103",
"O",
"B-T062",
"O",
"O",
"O",
... | [
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0038029",
"db_name": "UMLS"
},
{
"db_id": "C0038029",
"db_name": "UMLS"
},
{
"db_id": "C0038029",
"db_name": "UMLS"
},
{
... | [
"Protective",
"Effects",
"of",
"Sporoderm",
"-",
"Broken",
"Spores",
"of",
"Ganderma",
"lucidum",
"on",
"Growth",
"Performance",
",",
"Antioxidant",
"Capacity",
"and",
"Immune",
"Function",
"of",
"Broiler",
"Chickens",
"Exposed",
"to",
"Low",
"Level",
"of",
"Afl... | [
[
0,
10
],
[
11,
18
],
[
19,
21
],
[
22,
31
],
[
31,
32
],
[
32,
38
],
[
39,
45
],
[
46,
48
],
[
49,
57
],
[
58,
65
],
[
66,
68
],
[
69,
75
],
[
76,
87
],
[
... | Protective Effects of Sporoderm-Broken Spores of Ganderma lucidum on Growth Performance, Antioxidant Capacity and Immune Function of Broiler Chickens Exposed to Low Level of Aflatoxin B₁ This study was conducted to investigate the toxic effects of aflatoxin B₁ (AFB₁) and evaluate the effects of sporoderm-broken spores of Ganoderma lucidum (SSGL) in relieving aflatoxicosis in broilers. A total of 300 one-day-old male Arbor Acre broiler chickens were randomly divided into four dietary treatments; the treatment diets were: Control (a basal diet containing normal peanut meal); AFB₁ (the basal diet containing AFB₁ - contaminated peanut meal); SSGL (basal diet with 200 mg/kg of SSGL); AFB₁ + SSGL (supplementation of 200 mg/kg of SSGL in AFB₁ diet). The contents of AFB₁ in AFB₁ and AFB₁ + SSGL diets were 25.0 μg/kg in the starter period and 22.5 μg/kg in the finisher period. The results showed that diet contaminated with a low level of AFB₁ significantly decreased (p < 0.05) the average daily feed intake and average daily gain during the entire experiment and reduced (p < 0.05) serum contents of total protein IgA and IgG. Furthermore, a dietary low level of AFB₁ not only increased (p < 0.05) levels of hydrogen peroxide and lipid peroxidation, but also decreased (p < 0.05) total antioxidant capability, catalase, glutathione peroxidase, and hydroxyl radical scavenger activity in the liver and spleen of broilers. Moreover, the addition of SSGL to AFB₁ - contaminated diet counteracted these negative effects, indicating that SSGL has a protective effect against aflatoxicosis. |
[
"O",
"B-T103",
"B-T082",
"O",
"B-T007",
"I-T007",
"I-T007",
"O",
"B-T062",
"I-T062",
"O",
"O",
"O",
"O",
"B-T017",
"O",
"O",
"O",
"O",
"B-T007",
"I-T007",
"I-T007",
"I-T007",
"B-T007",
"I-T007",
"I-T007",
"I-T007",
"I-T007",
"I-T007",
"I-T007",
"I-T007",
... | [
{
"db_id": null,
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},
{
"db_id": "C0030958",
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},
{
"db_id": "C0449774",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0318127",
"db_name": "UMLS"
},
{
"db_id": "C0318127",
"db_name": "UMLS"
}... | [
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"Peptidoglycan",
"Pattern",
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"carnosus",
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"Influences",
"The",
"Gram",
"-",
"positive",
"bacterium",
"Staphylococcus",
"carnosus",
"("... | [
[
0,
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[
4,
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[
18,
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],
[
26,
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],
[
29,
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],
[
44,
52
],
[
53,
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],
[
59,
60
],
[
61,
69
],
[
70,
78
],
[
79,
82
],
[
83,
93
],
[
94,
97
],
[
9... | The Peptidoglycan Pattern of Staphylococcus carnosus TM300 - Detailed Analysis and Variations Due to Genetic and Metabolic Influences The Gram-positive bacterium Staphylococcus carnosus (S. carnosus) TM300 is an apathogenic staphylococcal species commonly used in meat starter cultures. As with all Gram-positive bacteria, its cytoplasmic membrane is surrounded by a thick peptidoglycan (PGN) or murein sacculus consisting of several layers of glycan strands cross-linked by peptides. In contrast to pathogenic staphylococci, mainly Staphylococcus aureus (S. aureus), the chemical composition of S. carnosus PGN is not well studied so far. UPLC/MS analysis of enzymatically digested S. carnosus TM300 PGN revealed substantial differences in its composition compared to the known pattern of S. aureus. While in S. aureus the uncross-linked stem peptide consists of a pentapeptide, in S. carnosus, this part of the PGN is shortened to tripeptides. Furthermore, we found the PGN composition to vary when cells were incubated under certain conditions. The collective overproduction of HlyD, FtsE and FtsX -a putative protein complex interacting with penicillin-binding protein 2 (PBP2)-caused the reappearance of classical penta stem peptides. In addition, under high sugar conditions, tetra stem peptides occur due to overflow metabolism. This indicates that S. carnosus TM300 cells adapt to various conditions by modification of their PGN. |
[
"O",
"O",
"O",
"O",
"B-T038",
"I-T038",
"O",
"B-T038",
"O",
"O",
"B-T170",
"I-T170",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
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"... | [
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"db_id... | [
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98,... | Risk and Predictors of Variceal Bleeding in Cirrhosis Patients Receiving Primary Prophylaxis With Non-Selective Beta-Blockers Prior studies have demonstrated the efficacy of non-selective beta-blockers (NSBB) in preventing first variceal bleeding in patients with cirrhosis. However, little is known about the overall effectiveness of NSBB in routine clinical care. We conducted a retrospective cohort study of cirrhotic patients without prior bleeding who initiated a NSBB (propranolol, nadolol) at any Veterans Administration facility between 2008 and 2013. The primary outcome was variceal bleeding within 12 months. We conducted Cox-proportional hazards analyses to identify demographic, clinical, and NSBB -related (type of NSBB, mean dose, dose change, and heart rate response) factors associated with variceal bleeding. Of 5,775 patients, 678 (11.7%) developed variceal bleeding. Mean daily dose of NSBB was <40 mg in 58.8%, 18.1% had either upward or downward titration in NSBB dose, and 9.8% had hemodynamic response. Patients who were younger, with ascites, greater medical comorbidity, and higher MELD (Model for end-stage liver disease) scores had a higher risk of variceal bleeding. Patients on a higher daily dose (>60 vs. <40 mg, adjusted hazard ratio (HR) 0.64; 95% confidence interval (CI): 0.51-0.81), who had either upward or downward dose titration (adjusted HR 0.69; 95% CI: 0.52-0.90 and 0.64; 95% CI 0.45-0.90, respectively), and those who achieved hemodynamic response (adjusted HR 0.75; 95% CI =0.57-1.0) had lower risk. Approximately 12% of patients bled while being on NSBB for primary prophylaxis. A higher NSBB dose and dose titration were protective; yet most patients did not have the NSBB dose titrated to the recommended levels. Our data highlight the need for careful monitoring of cirrhotic patients on NSBB. |
[
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... | [
{
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"db_id": null,... | [
"Amputation",
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... | Amputation trends for patients with lower extremity ulcers due to diabetes and peripheral artery disease using statewide data This study reports all-payer amputation rates using state -based administrative claims data for high- risk patients with lower extremity (LE) ulcers and concomitant peripheral artery disease (PAD), diabetes mellitus (DM), or combination PAD / DM. In addition, we characterize patient factors that affect amputation - free survival. We also attempted to create a measure of a patient's ability to manage chronic diseases or to access appropriate outpatient care for ulcer management by accounting for hospital and emergency department (ED) visits in the preceding 60 days to determine how this also affects amputation - free survival. Patients admitted to nonfederal hospitals, seen in an ED, or treated in an eligible ambulatory surgery center within California from 2005 through 2013 with an International Classification of Diseases, Ninth Revision, Clinical Modification diagnosis code for a disease-specific LE ulcer were identified in the California Office of Statewide Health Planning and Development database. All subsequent hospital, ED, and ambulatory surgery center visits and procedures are captured to identify whether a patient underwent major amputation. Yearly amputation rates were determined to analyze trends. Amputation - free survival for the PAD, DM, and PAD / DM groups was determined. Cox modeling was used to evaluate the effect of patient characteristics. There were 219,547 patients identified with an incident LE ulcer throughout the state. Of these, 131,731 were DM associated, 36,193 were PAD associated, and 51,623 were associated with both PAD and DM. From 2005 to 2013, the number of patients with LE ulcers who required inpatient admission, presented to the ED, or had outpatient procedures was stable. However, there was a statistically significant increase in overall disease -associated amputation rates from 5.1 in 2005 to 13.5 in 2013 (P < .001). Patients with PAD / DM had the greatest increase in amputation rates from 10 per 100 patients with LE ulcer s in 2005 to 28 per 100 patients in 2013 (P < .001). Despite that patients with PAD / DM were 8 years younger than patients with PAD only, they had similar amputation - free survival. Within all age groups, men had worse amputation - free survival than women did. Race did not predict amputation - free survival, but having multiple prior ED or hospital admissions was a significant predictor of worse amputation - free survival. Potentially preventable amputations associated with high- risk diseases are increasing among patients who require inpatient hospital admission, present to the ED, or require outpatient interventional treatment. This trend is most notable among patients with a combination of PAD and DM. Patients with repeated hospitalizations before admission for the LE ulcer had the highest risk of amputation. |
[
"O",
"O",
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"I-T103",
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"B-T058",
"I-T058",
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"B-T017",
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"B-T103",
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"B-T103",
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"O",
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"O",
"O",
"O",
"O",
"O",
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"O",
"O",
... | [
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... | [
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7... | Size effect of Au / PAMAM contrast agent on CT imaging of reticuloendothelial system and tumor tissue Polyamidoamine (PAMAM)-entrapped Au nanoparticles were synthesized with distinct sizes to figure out the size effect of Au -based contrast agent on CT imaging of passively targeted tissues. Au / PAMAM nanoparticles were first synthesized with narrow distribution of particles size of 22.2 ± 3.1, 54.2 ± 3.7, and 104.9 ± 4.7 nm in diameters. Size effect leads no significant difference on X-ray attenuation when Au / PAMAM was ≤0.05 mol/L. For CT imaging of a tumor model, small Au / PAMAM were more easily internalized via endocytosis in the liver, leading to more obviously enhanced contrast. Similarly, contrast agents with small sizes were more effective in tumor imaging because of the enhanced permeability and retention effect. Overall, the particle size of Au / PAMAM heavily affected the efficiency of CT enhancement in imaging RES and tumors. |
[
"B-T103",
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"I-T103",
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"I-T103",
"I-T103",
"I-T103",
"I-T103",
"O",
"O",
"B-T103",
"O",
"B-T005",
"I-T005",
"B-T005",
"I-T005",
"O",
"B-T005",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T038",
"I-T038",
"O",
"B-T038",
"O",
"B-T038... | [
{
"db_id": "C0041102",
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{
"db_id": null,
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{
"db_id": "C0067762",
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{
"db_id": "C0067762",
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{
"db_id": "C0067762",
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{
"db_id": "C0067762",
"db_name": "U... | [
"Trisaccharide",
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... | [
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30,
36
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[
44,
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[
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... | Trisaccharide containing α2,3-linked sialic acid is a receptor for mumps virus Mumps virus (MuV) remains an important pathogen worldwide, causing epidemic parotitis, orchitis, meningitis, and encephalitis. Here we show that MuV preferentially uses a trisaccharide containing α2,3-linked sialic acid in unbranched sugar chains as a receptor. Crystal structures of the MuV attachment protein hemagglutinin-neuraminidase (MuV - HN) alone and in complex with the α2,3-sialylated trisaccharide revealed that in addition to the interaction between the MuV - HN active site residues and sialic acid, other residues, including an aromatic residue, stabilize the third sugar of the trisaccharide. The importance of the aromatic residue and the third sugar in the MuV - HN - receptor interaction was confirmed by computational energy calculations, isothermal titration calorimetry studies, and glycan-binding assays. Furthermore, MuV - HN was found to bind more efficiently to unbranched α2,3-sialylated sugar chains compared with branched ones. Important ly, the strategically located aromatic residue is conserved among the HN protein s of sialic acid -using paramyxoviruses, and alanine substitution compromised their ability to support cell-cell fusion. These results suggest that not only the terminal sialic acid but also the adjacent sugar moiety contribute to receptor function for mumps and these paramyxoviruses. The distribution of structurally different sialylated glycans in tissues and organs may explain in part MuV's distinct tropism to glandular tissues and the central nervous system. In the crystal structure, the epitopes for neutralizing antibodies are located around the α-helices of MuV - HN that are not well conserved in amino acid sequences among different genotypes of MuV. This may explain the fact that MuV reinfection sometimes occurs. |
[
"B-T038",
"I-T038",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T062",
"O",
"O",
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"O",
"O",
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"O",
"O",
"O",
... | [
{
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"db_id": "C0935584",
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"db_id... | [
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... | [
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... | Executive functions, parental punishment, and aggression: Direct and moderated relations The main focus of the current study was to assess whether executive functions (EFs) moderate the effect of parental punishment on adolescent aggression. The sample were 370 participants (53% girls, 47% boys) enrolled at secondary and higher secondary levels and ranged in age between 13-19 years (M = 15.5, SD = 1.3). Participants were assessed on a self-report measure of aggression and two punishment measures, in addition to a demographic sheet. Then, they were individually assessed on four tests taken from the Delis-Kaplan Executive Functions System (D-KEFS) namely Trial Making Test (TMT), Design Fluency Test (DFT), Color Word Interference Test (CWIT), and Card Sorting Test (CST) to assess cognitive flexibility, nonverbal fluency, inhibition, and problem-solving ability, respectively. Correlation coefficients indicated that all four executive functioning measures and the two punishment measures were significantly correlated with aggression. Moderation analysis indicated that all EFs moderated the relationship between physical punishment and aggression, and only inhibition and problem-solving ability, but not cognitive flexibility and nonverbal fluency, moderated the relations between symbolic punishment and aggression. The findings support the hypothesis that EFs are protective personal factors that promote healthy adolescent adjustment in the presence of challenging environmental factors. |
[
"O",
"B-T033",
"I-T033",
"I-T033",
"I-T033",
"O",
"O",
"B-T007",
"I-T007",
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"O",
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"O",
"B-T038",
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"I-T204",
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"O",
"B-T103",
"O",
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"O",
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"... | [
{
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{
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{
"db_id": "C2825141",
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{
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}... | [
"Postprandial",
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... | Postprandial anti-hyperglycemic activity of marine Streptomyces coelicoflavus SRBVIT13 mediated gold nanoparticles in streptozotocin induced diabetic male albino Wister rats The present study focuses on the biosynthesis of gold nanoparticles (AuNPs) using Streptomyces coelicoflavus (S. coelicoflavus) SRBVIT13 isolated from marine salt pan soils collected from Ongole, Andhra Pradesh, India. The biosynthesised AuNPs are characterised by UV-visible spectroscopy, X-ray diffraction, Fourier transform infrared spectroscopy, high-resolution transmission electron microscopy and energy-dispersive X-ray analysis. Transmission electron microscopy study suggests that the biosynthesised AuNPs are spherical in shape within a size range of 12-20 nm (mean diameter as 14 nm). The anti-type II diabetes activity of AuNPs is carried out by testing it in vitro α-glucosidase and α-amylase enzyme inhibition activity and in vivo postprandial anti-hyperglycemic activity in sucrose and glucose -loaded streptozotocin induced diabetic albino Wister rats. AuNPs has shown a significant inhibitory activity of 84.70 and 87.82% with IC50 values of 67.65 and 65.59 μg/mL to α-glucosidase and α-amylase enzymes, while the diabetic rats have shown significant reduction in the post postprandial blood glucose level by 57.80 and 88.09%, respectively compared with control group after AuNPs treatment at the concentration of 300 and 600 mg/kg body weight. Hence, this biosynthesised AuNPs might be useful in combating type II diabetes mellitus for the betterment of human life. |
[
"O",
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"I-T058",
"O",
"O",
"B-T038",
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"I-T038",
"O",
"B-T082",
"O",
"O",
"O",
"O",
"B-T058",
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"O",
"B-T170",
"O",
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"B-T038",
"I-T038",
"O",
"B-T058",
"O",
"B-T058",
"I-T058",
"O"... | [
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"db_id": "C1963724",
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9... | The association between HIV, antiretroviral therapy, and gestational diabetes mellitus The widespread, chronic use of antiretroviral therapy raises questions concerning the metabolic consequences of HIV infection and treatment. Antiretroviral therapy, and specifically protease inhibitors, has been associated with hyperglycemia. As pregnant women are vulnerable to development of hyperglycemia, the objective of this study was to explore existing literature on the relationship between HIV infection, HIV treatment, and gestational diabetes mellitus (GDM). A systematic search was conducted in six databases for articles providing data on HIV-positivity, protease inhibitor exposure, and GDM or glucose intolerance development in pregnancy. The quality of articles was evaluated using an adapted Cochrane Collaboration bias assessment tool. Risk ratios were generated from pooled data using meta-analysis by the Mantel-Haenszel method. Of 891 references screened, six studies on the role of HIV-positivity, 10 on protease inhibitor use, and two on both were included. Meta-analysis showed no significant relationship between HIV infection and the development of GDM [risk ratio 0.80, 95% confidence interval (CI): 0.47-1.37, I = 0%]. Meta-analysis of protease inhibitor exposure showed increased GDM in studies using first-generation protease inhibitors (risk ratio 2.29, 95% CI: 1.46-3.58) and studies using the strictest diagnosis criteria, the National Diabetes Data Group criteria for 3-h oral glucose tolerance test (risk ratio 3.81, 95% CI: 2.18-6.67). Meta-analysis showed no significant association between HIV-positivity and GDM. Significance of protease inhibitor use was limited to studies using the strictest diagnostic criteria for GDM. Results are limited by high risk of bias. Well designed prospective studies are needed to further clarify this relationship and its consequences for clinical practice. |
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"B-T103",
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"I-T103",
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"B-T103",
"I-T103",
"O",
"B-T017",
"I-T017",
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"I-T082",
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"B-T038",
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"O",
"B-T103",
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"O... | [
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{
"db_id": null,
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{
"db_id": "C0015980",
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{
"db_id... | [
"Curcumin",
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8... | Curcumin synergistically increases effects of β-interferon and retinoic acid on breast cancer cells in vitro and in vivo by up-regulation of GRIM-19 through STAT3 - dependent and STAT3 - independent pathways The study aimed to investigate the effects of combination treatment of curcumin and β-interferon (IFN-β)/ retinoic acid (RA) on breast cancer cells, including cell viability, apoptosis and migration, and to determine the mechanisms related to GRIM-19 through STAT3 - dependent and STAT3 - independent pathways. The following groups were used for the in vitro experiment: control siRNA, GRIM-19 siRNA, IFN-β / RA and IFN-β / RA + curcumin. Cell viability is by the MTT method, cell apoptosis by flow cytometry and cell migration by wound healing experiment; GRIM-19, STAT3, survivin, Bcl-2, GADD153 and COX-2 expression was measured by Western blot. In vivo experiment, MCF-7 cells were subcutaneously injected into nude mice. GRIM-19 siRNA promoted MCF-7 cell proliferation and migration; inhibited cell apoptosis; and promoted the expression of STAT3, survivin, Bcl-2 and MMP-9. IFN-β / RA inhibited cell proliferation and migration; promoted cell apoptosis; up-regulated GRIM-19; and inhibited the expression of STAT3, survivin, Bcl-2 and MMP-9. Combination treatment of curcumin and IFN-β / RA had a stronger effect than that of the IFN-β / RA group. In addition, curcumin and IFN-β / RA combination inhibited the expression of COX-2 and up-regulated GADD153. Curcumin synergistically increases the effects of IFN-β / RA on breast cancer cells. The mechanism may be related to the up-regulation of GRIM-19 through STAT3 - dependent and STAT3 - independent pathways. |
[
"B-T103",
"I-T103",
"I-T103",
"O",
"O",
"B-T103",
"I-T103",
"O",
"B-T058",
"O",
"B-T058",
"O",
"O",
"O",
"O",
"B-T103",
"I-T103",
"I-T103",
"I-T103",
"I-T103",
"B-T103",
"I-T103",
"O",
"B-T103",
"O",
"O",
"B-T103",
"I-T103",
"I-T103",
"I-T103",
"I-T103",
... | [
{
"db_id": "C0010029",
"db_name": "UMLS"
},
{
"db_id": "C0010029",
"db_name": "UMLS"
},
{
"db_id": "C0010029",
"db_name": "UMLS"
},
{
"db_id": null,
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},
{
"db_id": null,
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},
{
"db_id": "C0065055",
"db_name": "UMLS"
}... | [
"Corn",
"oil",
"intake",
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10... | Corn oil intake favorably impacts lipoprotein cholesterol, apolipoprotein and lipoprotein particle levels compared with extra-virgin olive oil Corn oil (CO) and extra-virgin olive oil (EVOO) are rich sources of unsaturated fatty acids (UFA), but UFA profiles differ among oils, which may affect lipoprotein levels. The objective of this study was to assess the effects of CO versus EVOO intake on fasting lipoprotein and subfraction cholesterol levels, apolipoprotein (apo) A1, apo B, and low-density lipoprotein particle concentrations in men and women. As part of a weight maintenance diet, men and women were provided with food items prepared with 54 g per day of CO or EVOO (21-day treatment, 21-day washout) in a randomized, double-blind, controlled-feeding, crossover trial. Fasting lipoprotein cholesterol and related variables were determined with density gradient ultracentrifugation. Among the 54 completers, CO reduced total cholesterol, low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C), non-high-density lipoprotein cholesterol (non-HDL-C), apo B and LDL particle concentration to a greater extent compared with EVOO intake. Changes in LDL-C and VLDL-C contributed to the larger reduction in non-HDL-C with CO compared with EVOO intake (-0.39 mmol/l vs -0.04 mmol/l; P<0.001). The larger reduction in LDL-C by CO intake was attributable to changes (P<0.05) caused by CO vs EVOO in large LDL1+2-C (-0.22 mmol/l) and intermediate-density lipoprotein cholesterol (-0.12 mmol/l). HDL-C responses did not differ between treatments, but apo A1 increased more with EVOO compared with CO intake (4.6 versus 0.7 mg/dl, respectively, P=0.016). CO intake reduced atherogenic lipoprotein cholesterol and particle concentrations to a larger extent than did EVOO, which may have implications for cardiovascular disease risk. |
[
"B-T204",
"O",
"B-T098",
"B-T204",
"B-T204",
"B-T204",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T017",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T170",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"... | [
{
"db_id": "C2669649",
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{
"db_id": null,
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},
{
"db_id": "C0241329",
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},
{
"db_id": "C1070068",
"db_name": "UMLS"
},
{
"db_id": "C0040811",
"db_name": "UMLS"
},
{
"db_id": "C0037378",
"db_name": "U... | [
"Moorean",
"and",
"Tahitian",
"Partula",
"tree",
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8,
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21,
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40,
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49,
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7... | Moorean and Tahitian Partula tree snail survival after a mass extinction: New genomic insights using museum specimens Natural history museum collections provide a biodiversity window into the past and are of particular importance to the study of extinction -impacted clades such as the Pacific Island tree snail family Partulidae. Deliberate introduction of the predatory rosy wolf snail Euglandina rosea in the late 20th century led to the extinction / extirpation of 55/61 Society Island Partulidae species. In this study, we phylogenomically investigated the inter-relationships of the three surviving Society Island valley Partula species: P. taeniata (Moorea), P. clara and P. hyalina (Tahiti). All three formed a distinct clade in earlier mitochondrial phylogenies. Using Next Generation Sequencing (NGS) double digested Restriction Associated DNA sequencing (ddRADseq), we found that 46-year-old lyophilized museum specimens produced similar numbers of reads, sequencing depth, and loci as 10-year old ethanol -preserved collections. Phylogenomic trees indicated that Tahitian P. clara and P. hyalina are the result of a single founding lineage from Moorea, contrasting previous mitochondrial results and clarifying the enigmatic taxonomic status of P. c. incrassa. Our study highlights the utility and viability of NGS techniques for museum specimens and their increased resolution of evolutionary patterns. Sampling will be expanded to include the remaining Society Island partulid taxa to further explore the evolutionary history of this radiation. |
[
"O",
"O",
"O",
"O",
"B-T031",
"O",
"O",
"B-T103",
"I-T103",
"I-T103",
"O",
"B-T098",
"O",
"O",
"O",
"B-T033",
"I-T033",
"I-T033",
"B-T038",
"B-T031",
"O",
"O",
"B-T103",
"I-T103",
"I-T103",
"O",
"O",
"O",
"B-T098",
"O",
"B-T038",
"O",
"O",
"O",
"O"... | [
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{
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{
"db_id": null,
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{
"db_id": null,
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{
"db_id": "C0032105",
"db_name": "UMLS"
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{
"db_id": null,
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{
"db_id": null,... | [
"Early",
"second",
"-",
"trimester",
"plasma",
"levels",
"of",
"NT",
"-",
"proBNP",
"in",
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"-",
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37,
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[
40,
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[
42,
43
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[
43,
49
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[
50,
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53,
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59,
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6... | Early second-trimester plasma levels of NT-proBNP in women who subsequently develop early-onset preeclampsia Plasma levels of NT-proBNP are elevated in women with preeclampsia at the time of diagnosis. The objective of this case-control study was to evaluate N-terminal proBNP (NT-proBNP) in maternal plasma as an early second-trimester biomarker for prediction of early-onset preeclampsia. In early second-trimester samples, women who later developed preeclampsia at gestational age 34 wk + 0 or earlier (n = 16) had similar plasma levels of NT-proBNP (median 51.8, range 26.1-131.9 pg/ml) as women with uncomplicated pregnancy outcomes (n = 43) (53.0, 14.9-184.2 pg/ml). The early second-trimester level of NT-proBNP cannot therefore be used as a predictive biomarker of early-onset preeclampsia. |
[
"O",
"B-T058",
"I-T058",
"O",
"O",
"O",
"B-T074",
"I-T074",
"I-T074",
"B-T062",
"O",
"B-T037",
"I-T037",
"O",
"O",
"O",
"O",
"B-T017",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T201",
"I-T201... | [
{
"db_id": null,
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},
{
"db_id": "C0041618",
"db_name": "UMLS"
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{
"db_id": "C0041618",
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"db_id": null,
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"db_id": null,
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"db_id... | [
"Can",
"diaphragmatic",
"ultrasonography",
"performed",
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"rapid",
"shallow",
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0,
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55,
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56,
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62,
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9... | Can diaphragmatic ultrasonography performed during the T-tube trial predict weaning failure? The role of diaphragmatic rapid shallow breathing index The rapid shallow breathing index (RSBI), which is the ratio between respiratory rate (RR) and tidal volume (VT), is one of the most widely used indices to predict weaning outcome. Whereas the diaphragm plays a fundamental role in generating VT, in the case of diaphragmatic dysfunction the inspiratory accessory muscles may contribute. If this occurs during a weaning trial, delayed weaning failure is likely since the accessory muscles are more fatigable than the diaphragm. Hence, we hypothesised that the traditional RSBI could be implemented by substituting VT with the ultrasonographic evaluation of diaphragmatic displacement (DD). We named the new index the diaphragmatic - RSBI (D - RSBI). The aim of this study was to compare the ability of the traditional RSBI and D - RSBI to predict weaning failure in ready-to-wean patients. We performed a prospective observational study. During a T-tube spontaneous breathing trial (SBT) we simultaneously evaluated right hemidiaphragm displacement (i.e., DD) by using M-mode ultrasonography as well as the RSBI. Outcome of the weaning attempt, length of mechanical ventilation, length of intensive care unit and hospital stay, and hospital mortality were recorded. Receiver operator characteristic (ROC) curves were used to evaluate the diagnostic accuracy of D - RSBI and RSBI. We enrolled 51 patients requiring mechanical ventilation for more than 48 h who were ready to perform a SBT. Most of the patients, 34 (66 %), were successfully weaned from mechanical ventilation. When considering the 17 patients that failed the weaning attempt, 11 (64 %) had to be reconnected to the ventilator during the SBT, three (18 %) had to be re-intubated within 48 h of extubation, and three (18 %) required non-invasive ventilation support within 48 h of extubation. The areas under the ROC curves for D - RSBI and RSBI were 0.89 and 0.72, respectively (P = 0.006). D - RSBI (RR / DD) was more accurate than traditional RSBI (RR / VT) in predicting the weaning outcome. Our clinical trial was retrospectively registered with ClinicalTrials.gov (identifier: NCT02696018). ClinicalTrials.gov processed our record on 25 February 2016. |
[
"B-T058",
"I-T058",
"I-T058",
"I-T058",
"I-T058",
"O",
"O",
"B-T097",
"I-T097",
"O",
"B-T058",
"I-T058",
"I-T058",
"I-T058",
"I-T058",
"O",
"B-T058",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T058",
"I-T058",
"I-T058",
"O",
"B-T058",
... | [
{
"db_id": "C1171216",
"db_name": "UMLS"
},
{
"db_id": "C1171216",
"db_name": "UMLS"
},
{
"db_id": "C1171216",
"db_name": "UMLS"
},
{
"db_id": "C1171216",
"db_name": "UMLS"
},
{
"db_id": "C1171216",
"db_name": "UMLS"
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{
"db_id": null,
"db_name": ... | [
"Cross",
"-",
"border",
"reproductive",
"care",
":",
"an",
"Ethics",
"Committee",
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"reproductive",
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"worldwide",
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0,
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5,
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6,
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26,
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30,
31
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[
32,
34
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[
35,
41
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[
42,
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52,
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73,... | Cross-border reproductive care: an Ethics Committee opinion Cross-border reproductive care (CBRC) is a growing worldwide phenomenon, raising questions about why assisted reproductive technology (ART) patients travel abroad, what harms and benefits may result, and what duties health-care providers may have in advising and treating patients who travel for reproductive services. Cross-border care offers benefits and poses harms to ART stakeholders, including patients, offspring, providers, gamete donors, gestational carriers, and local populations in destination countries. This document replaces the previous document of the same name, last published in 2013 (Fertil Steril 2013;100:645-50). |
[
"B-T017",
"B-T058",
"B-T038",
"I-T038",
"O",
"O",
"O",
"O",
"B-T017",
"B-T038",
"I-T038",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T091",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T170",
"I-T170",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
... | [
{
"db_id": "C0024687",
"db_name": "UMLS"
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{
"db_id": "C0162590",
"db_name": "UMLS"
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{
"db_id": "C0333988",
"db_name": "UMLS"
},
{
"db_id": "C0333988",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
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}... | [
"Mandibular",
"intraosseous",
"pseudocarcinomatous",
"hyperplasia",
":",
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"case",
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"Mandibular",
"pseudocarcinomatous",
"hyperplasia",
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"benign",
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"report",
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"rare",... | [
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0,
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11,
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24,
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44,
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55,
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[
59,
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[
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[
71,
81
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[
82,
101
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[
102,
113
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[
114,
116
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[
117,
118
],
... | Mandibular intraosseous pseudocarcinomatous hyperplasia: a case report Mandibular pseudocarcinomatous hyperplasia is a rare and generally benign pathology. We report on one of these rare cases. The case history of a 73-year-old white man stated that he had a carcinoma of the oropharynx, which was primarily treated with radiotherapy and chemotherapy 4 years prior. As a result of radiotherapy he developed an osteoradionecrosis of his mandible and a consecutive pathological fracture of his left mandibular angle. Subsequent osteosynthesis was performed with a reconstruction plate. When we first saw him, his reconstruction plate was partially exposed with intraoral and extraoral fistulation. The resected bone of his defect-bordering jaw showed the typical pathohistological findings of an intraosseous mandibular pseudocarcinomatous hyperplasia. After a first reconstruction attempt with an iliac crest graft failed, definitive reconstruction of his mandible with a microvascular anastomosed fibula graft was achieved. Intraosseous pseudocarcinomatous hyperplasia of the mandible is a rare differential diagnosis in maxillofacial surgery. Besides other benign epithelial neoplasms, such as calcifying epithelial odontogenic tumor, squamous odontogenic tumor, or different forms of ameloblastoma, the far more frequent invasive squamous cell carcinoma needs to be excluded. A misinterpretation of pseudocarcinomatous hyperplasia as squamous cell carcinoma must be avoided because it can lead to a massive overtreatment. |
[
"O",
"B-T017",
"O",
"O",
"B-T017",
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"O",
"O",
"O",
"B-T201",
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"B-T038",
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"I-T038",
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"I-T038",
"O",
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"I-T038",
"O",
"B-T038",
"O",
"O",
"O",
"O",
"O",
"B-T038",
"I-T038",
"I... | [
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{
"db_id": null,
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{
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{
"db_id": "C1422394",
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{
"db_id": "C1422394",
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{
... | [
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[
83... | A Variant in the BACH2 Gene Is Associated With Susceptibility to Autoimmune Addison's Disease in Humans Autoimmune Addison's disease (AAD) is a rare but highly heritable condition. The BACH2 protein plays a crucial role in T lymphocyte maturation, and allelic variation in its gene has been associated with a number of autoimmune conditions. We aimed to determine whether alleles of the rs3757247 single nucleotide polymorphism (SNP) in the BACH2 gene are associated with AAD. This case-control association study was performed in two phases using Taqman chemistry. In the first phase, the rs3757247 SNP was genotyped in 358 UK AAD subjects and 166 local control subjects. Genotype data were also available from 5154 healthy UK controls from the Wellcome Trust (WTCCC2) for comparison. In the second phase, the SNP was genotyped in a validation cohort comprising 317 Norwegian AAD subjects and 365 controls. The frequency of the minor T allele was significantly higher in subjects with AAD from the United Kingdom compared to both the local and WTCCC2 control cohorts (58% vs 45 and 48%, respectively) (local controls, P = 1.1 × 10(-4); odds ratio [OR], 1.68; 95% confidence interval [CI], 1.29-2.18; WTCCC2 controls, P = 1.4 × 10(-6); OR, 1.44; 95% CI, 1.23-1.69). This finding was replicated in the Norwegian validation cohort (P = .0015; OR, 1.41; 95% CI, 1.14-1.75). Subgroup analysis showed that this association is present in subjects with both isolated AAD (OR, 1.53; 95% CI, 1.22-1.92) and autoimmune polyglandular syndrome type 2 (OR, 1.37; 95% CI, 1.12-1.69) in the UK cohort, and with autoimmune polyglandular syndrome type 2 in the Norwegian cohort (OR, 1.58; 95% CI, 1.22-2.06). We have demonstrated, for the first time, that allelic variability at the BACH2 locus is associated with susceptibility to AAD. Given its association with multiple autoimmune conditions, BACH2 can be considered a "universal" autoimmune susceptibility locus. |
[
"B-T038",
"B-T033",
"O",
"B-T033",
"I-T033",
"I-T033",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T038",
"I-T038",
"I-T038",
"I-T038",
"I-T038",
"O",
"B-T038",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O... | [
{
"db_id": "C1263846",
"db_name": "UMLS"
},
{
"db_id": "C1457887",
"db_name": "UMLS"
},
{
"db_id": null,
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},
{
"db_id": "C0746919",
"db_name": "UMLS"
},
{
"db_id": "C0746919",
"db_name": "UMLS"
},
{
"db_id": "C0746919",
"db_name": "U... | [
"ADHD",
"symptoms",
"in",
"non",
"-",
"treatment",
"seeking",
"young",
"adults",
":",
"relationship",
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"-",
"deficit",
"hyperactivity",
"disorder",
"(",
"ADHD",
")",
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"associated",
"with",
... | [
[
0,
4
],
[
5,
13
],
[
14,
16
],
[
17,
20
],
[
20,
21
],
[
21,
30
],
[
31,
38
],
[
39,
44
],
[
45,
51
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[
51,
52
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[
53,
65
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[
66,
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71,
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7... | ADHD symptoms in non-treatment seeking young adults: relationship with other forms of impulsivity Attention-deficit hyperactivity disorder (ADHD) has been associated with various manifestations of impulsivity in adults, including elevated rates of other impulsive disorders, substance use, questionnaire -based impulsivity scores, and inhibitory dysregulation on neurocognitive tests. The relationship between ADHD and all these other forms of impulsivity has yet to be explored within the context of a single comprehensive study. A total of 423 young adults, who gambled ≥5 times in the preceding year, were recruited using media advertisements and undertook detailed assessment including structured psychiatric interview, questionnaires, and neurocognitive tests. Participants with ADHD symptoms were identified using the Adult ADHD Self-Report Scale Screener (ASRS-V1.1) and were compared to controls using multivariate analysis of variance (MANOVA). ADHD symptoms were found in 20.3% of the sample, but only 7.3% of these subjects had ever received a formal diagnosis. ADHD symptoms were associated with significantly lower quality of life, lower self-esteem, higher emotional dysregulation, higher impulsivity questionnaire scores, more problematic Internet use, greater occurrence of psychiatric disorders, and impaired stop-signal reaction times. Of these variables, stop-signal reaction times and Barratt attentional impulsiveness were the strongest predictors of group classification. ADHD symptoms are common and under-diagnosed in young adults who gamble, and are most strongly linked with certain other types of impulsivity (questionnaire - and cognitive -based measures) and with emotional dysregulation, suggesting that these are each important considerations in understanding the pathophysiology of the disorder, but also potential treatment targets. It is necessary to question whether treatment for adult ADHD could be enhanced by considering self-esteem, emotional reactivity, and impaired inhibitory control as specific treatment targets, in addition to the core diagnostic symptoms of the disorder. |
[
"B-T062",
"O",
"O",
"B-T103",
"I-T103",
"I-T103",
"I-T103",
"I-T103",
"I-T103",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"... | [
{
"db_id": "C2603343",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C3153039",
"db_name": "UMLS"
},
{
"db_id": "C3153039",
"db_name": "UMLS"
},
{
"db_id": "C3153039",
"db_name": "UMLS"
}... | [
"Study",
"of",
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"liquid",
"-",
"film",
"-",
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"condition",
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"an",
"important",
"factor",
"in",
"aquaculture",
"systems",
... | [
[
0,
5
],
[
6,
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],
[
9,
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[
13,
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[
19,
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[
20,
24
],
[
24,
25
],
[
25,
32
],
[
33,
42
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[
43,
45
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[
46,
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[
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[
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70,... | Study of the liquid-film-forming apparatus as an alternative aeration system: design criteria and operating condition Aeration is an important factor in aquaculture systems because it is a vital condition for all organisms that live in water and respire aerobically. Generally, mechanical surface aerators are widely used in Thailand due to their advantage for increasing dissolved oxygen (DO) and for their horizontal mixing of aquaculture ponds with large surface areas. However, these systems still have some drawbacks, primarily the low oxygen transfer efficiency (OTE) and energy. Regarding this issue, alternative aeration systems should be studied and applied. Therefore, this research aims to study the aeration mechanism obtained by the diffused-air aeration combined with a liquid-film-forming apparatus (LFFA). The effect of gas flow rates, types, and patterns of aerator installation were investigated in an aquaculture pond of 10 m × 10 m × 1.5 m. The analytical parameters were volumetric mass transfer coefficient (kLa), OTE, and aeration efficiency (AE). From the results, the '4-D' with partitions was proposed as the suitable pattern for the LFFA installation. The advantage could be obtained from high energy performance with 1.2 kg/kW h of AE. Then, the operation conditions can be applied as a design guideline for this alternative aeration system in the aquaculture ponds. |
[
"B-T038",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T007",
"I-T007",
"B-T082",
"O",
"O",
"B-T082",
"B-T007",
"I-T007",
"B-T082",
"O",
"O",
"O",
"B-T082",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
... | [
{
"db_id": "C0015219",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,... | [
"Evolutionary",
"History",
"and",
"Ongoing",
"Transmission",
"of",
"Phylogenetic",
"Sublineages",
"of",
"Mycobacterium",
"tuberculosis",
"Beijing",
"Genotype",
"in",
"China",
"Mycobacterium",
"tuberculosis",
"Beijing",
"genotype",
"originated",
"in",
"China",
"and",
"ha... | [
[
0,
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[
13,
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],
[
21,
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],
[
25,
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],
[
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[
46,
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[
49,
61
],
[
62,
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[
74,
76
],
[
77,
90
],
[
91,
103
],
[
104,
111
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[
112,
120
],
... | Evolutionary History and Ongoing Transmission of Phylogenetic Sublineages of Mycobacterium tuberculosis Beijing Genotype in China Mycobacterium tuberculosis Beijing genotype originated in China and has undergone a dramatic population growth and global spread in the last century. Here, a collection of M. tuberculosis Beijing family isolates from different provinces across all China was genotyped by high-resolution (24-MIRU-VNTR) and low-resolution, high-rank (modern and ancient sublineages) markers. The molecular profiles and global and local phylogenies were compared to the strain phenotype and patient data. The phylogeographic patterns observed in the studied collection demonstrate that large-scale (but not middle/small-scale) distance remains one of the decisive factors of the genetic divergence of M. tuberculosis populations. Analysis of diversity and network topology of the local collections appears to corroborate a recent intriguing hypothesis about Beijing genotype originating in South China. Placing our results within the Eurasian context suggested that important Russian B0/W148 and Asian / Russian A0/94-32 epidemic clones of the Beijing genotype could trace their origins to the northeastern and northwestern regions of China, respectively. The higher clustering of the modern isolates in children and lack of increased MDR rate in any sublineage suggest that not association with drug resistance but other (e.g., speculatively, virulence -related) properties underlie an enhanced dissemination of the evolutionarily recent, modern sublineage of the Beijing genotype in China. |
[
"B-T058",
"I-T058",
"O",
"B-T058",
"I-T058",
"O",
"B-T058",
"O",
"B-T103",
"I-T103",
"O",
"B-T103",
"O",
"O",
"O",
"B-T038",
"I-T038",
"B-T038",
"O",
"B-T038",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T038",
"I-T038",
"I-T038",
"O",
"O",
"O",
"O",
"O"... | [
{
"db_id": "C0949168",
"db_name": "UMLS"
},
{
"db_id": "C0949168",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0001563",
"db_name": "UMLS"
},
{
"db_id": "C0001563",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
}... | [
"Clinical",
"comparison",
"of",
"oral",
"administration",
"and",
"viscosupplementation",
"of",
"hyaluronic",
"acid",
"(",
"HA",
")",
"in",
"early",
"knee",
"osteoarthritis",
"Osteoarthritis",
"(",
"OA",
")",
"is",
"a",
"progressive",
",",
"chronic",
"and",
"dege... | [
[
0,
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[
9,
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[
20,
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],
[
23,
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],
[
28,
42
],
[
43,
46
],
[
47,
67
],
[
68,
70
],
[
71,
81
],
[
82,
86
],
[
87,
88
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[
88,
90
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[
90,
91
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[
9... | Clinical comparison of oral administration and viscosupplementation of hyaluronic acid (HA) in early knee osteoarthritis Osteoarthritis (OA) is a progressive, chronic and degenerative joint disease characterized by a loss of articular cartilage. Treatment of OA is largely palliative based on nonsteroidal anti-inflammatory drugs, opioids and injections of steroids. Regarding conservative treatment, intra-articular injections of hyaluronic acid (HA) can play a role in early symptomatic knee OA. Between August 2015 and September 2015, sixty patients (32 males and 28 females) between 40 and 70 years old were randomly allocated into two groups: Half were treated with three weekly intra-articular injections of hyaluronic acid 1.6 % (group A), while the others were treated with Syalox 300 Plus(®) (hyaluronic acid 300 mg + Boswellia serrata extract 100 mg) 1 tab / die for 20 days and afterward Syalox 150(®) (hyaluronic acid 150 mg) 1 tab / die for other 20 days (group B). All patients were evaluated clinically with American Knee Society Score (AKSS) and visual analogue scale (VAS) for the pain before the treatment and after 3 months. AKSS of the patients in both groups was significantly increased by the treatment, and VAS score was significantly reduced. In both groups, two subgroups were created with patients older than 60 years and patients younger than 60 years. Better results are reported in younger patients of group A and older subjects in group B. Despite several limitations, the results of the study have shown that HA injection and oral administration may have beneficial therapeutic effects on patients with early osteoarthritis. Different outcomes in younger and older subject suggested a combined therapy first with local infiltrations and then with oral composition. |
[
"B-T038",
"B-T170",
"O",
"B-T038",
"B-T058",
"O",
"B-T082",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T062",
"I-T062",
"I-T062",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T062",
"O",
"B-T062",
"O",
"O",
"B-T170",
"O",
"B-T038",
"O",
"O",
"B-T038",
... | [
{
"db_id": "C0025361",
"db_name": "UMLS"
},
{
"db_id": "C0038951",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0011311",
"db_name": "UMLS"
},
{
"db_id": "C0920467",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
}... | [
"KAP",
"Surveys",
"and",
"Dengue",
"Control",
"in",
"Colombia",
":",
"Disentangling",
"the",
"Effect",
"of",
"Sociodemographic",
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"Multiple",
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"Analysis",
"During",
"the",
"last",
"few",
"decades",
",",
"several",
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"ha... | [
[
0,
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],
[
4,
11
],
[
12,
15
],
[
16,
22
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[
23,
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[
31,
33
],
[
34,
42
],
[
42,
43
],
[
44,
57
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[
58,
61
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62,
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69,
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72,
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8... | KAP Surveys and Dengue Control in Colombia: Disentangling the Effect of Sociodemographic Factors Using Multiple Correspondence Analysis During the last few decades, several studies have analyzed and described knowledge, attitudes, and practices (KAP) of populations regarding dengue. However, few studies have applied geometric data analytic techniques to generate indices from KAP domains. Results of such analyses have not been used to determine the potential effects of sociodemographic variables on the levels of KAP. The objective was to determine the sociodemographic factors related to different levels of KAP regarding dengue in two hyper-endemic cities of Colombia, using a multiple correspondence analysis (MCA) technique. In the context of a cluster randomized trial, 3,998 households were surveyed in Arauca and Armenia between 2012 and 2013. To generate KAP indexes, we performed a MCA followed by a hierarchical cluster analysis to classify each score in different groups. A quantile regression for each of the score groups was conducted. KAP indexes explained 56.1%, 79.7%, and 83.2% of the variance, with means of 4.2, 1.4, and 3.2 and values that ranged from 1 to 7, 7 and 11, respectively. The highest values of the index denoted higher levels of knowledge and practices. The attitudes index did not show the same relationship and was excluded from the analysis. In the quantile regression, age (0.06; IC: 0.03, 0.09), years of education (0.14; IC: 0.06, 0.22), and history of dengue in the family (0.21; IC: 0.12, 0.31) were positively related to lower levels of knowledge regarding dengue. The effect of such factors gradually decreased or disappeared when knowledge was higher. The practices indexes did not evidence a correlation with sociodemographic variables. These results suggest that the transformation of categorical variables into a single index by the use of MCA is possible when analyzing knowledge and practices regarding dengue from KAP questionnaires. Additionally, the magnitude of the effect of socioeconomic variables on the knowledge scores varies according to the levels of knowledge, suggesting that other factors might be influencing higher levels of knowledge. |
[
"B-T062",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T017",
"I-T017",
"B-T058",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T017",
"I-T017",
"O",
"O",
"O",
"O",
"B-T062",
"O",
"O",
"B-T062",
"O",
"O",
"O",
"O",
"O",
"B-T017",
"I-T017",
"B-T058... | [
{
"db_id": "C0936012",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
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},
{
"db_id": null,
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},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,... | [
"Analysis",
"of",
"soft",
"-",
"tissue",
"complications",
"of",
"volar",
"plate",
"fixation",
"for",
"managing",
"distal",
"radius",
"fractures",
"and",
"clinical",
"effect",
"while",
"preserving",
"pronator",
"quadratus",
"The",
"aim",
"of",
"the",
"study",
"wa... | [
[
0,
8
],
[
9,
11
],
[
12,
16
],
[
16,
17
],
[
17,
23
],
[
24,
37
],
[
38,
40
],
[
41,
46
],
[
47,
52
],
[
53,
61
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[
62,
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[
66,
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[
75,
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8... | Analysis of soft-tissue complications of volar plate fixation for managing distal radius fractures and clinical effect while preserving pronator quadratus The aim of the study was to analysis soft-tissue complications of volar plate fixation and it's prevention strategies along with exploring clinical effects of preserving pronator quadratus (PQ) muscle. From February 2011 to February 2013, sixty-five patients with distal radius fracture underwent open reduction and internal fixation with the volar locking palmar plates. The group with preserving PQ involved 30 patients and group with PQ repair involved 35 patients. Surgeons must took great care of not -letting drill pierce dorsal cortical bone rapidly and dorsal carpal tangential fluoroscopy was also taken in addition to lateral fluoroscopy to get accurate screw length. Volar plate must be placed not go beyond the watershed region of distal radius. The wrist pain, forearm range of motion, grip strength, wrist functional recovery score, X-ray and CT imaging were followed-up after surgery. Two groups were compared for Clinical efficacy. The minimum follow-up for the whole cohort was one year. The relevant post operative data were collected after 2 weeks, 6 weeks, 3 and 12 month respectively. Fractures healing after postoperative 3 months are significant in X -ray and CT imaging. Fixation position and stability were good, but each group had one case with a screw piercing the dorsal cortical. The - differences between the two groups were significant regarding the wrist pain, forearm range of motion, grip and strength at 2 and 6 weeks after operation, but not significant at 3 and 12 month after operation. The differences between the two groups were also significant regarding wrist functional scores at 6 weeks, but not significant at 3 and 12 month after operation. Drilling the dorsal cortical bone gently and accurate screws length can avoid extensor tendon injury. - Dorsal carpal tangential fluoroscopy is a useful supplement for accurate screws length besides lateral fluoroscopy. Volar plate's position not go beyond the watershed region of distal radius is the key factor in reducing the flexor tendon injury and preservation of the PQ muscle can also prevent the flexor tendon -injury, yield better early wrist function and shorten rehabilitation time. |
[
"O",
"O",
"O",
"O",
"O",
"B-T103",
"I-T103",
"I-T103",
"I-T103",
"I-T103",
"O",
"B-T031",
"O",
"O",
"O",
"O",
"O",
"B-T204",
"I-T204",
"B-T103",
"I-T103",
"O",
"O",
"O",
"O",
"O",
"B-T033",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T103",
"I-T103",
... | [
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
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},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C1175041",
"db_name": "UMLS"
},
{
"db_id": "C117... | [
"Assessment",
"of",
"the",
"interaction",
"of",
"Portland",
"cement",
"-",
"based",
"materials",
"with",
"blood",
"and",
"tissue",
"fluids",
"using",
"an",
"animal",
"model",
"Portland",
"cement",
"used",
"in",
"the",
"construction",
"industry",
"improves",
"its... | [
[
0,
10
],
[
11,
13
],
[
14,
17
],
[
18,
29
],
[
30,
32
],
[
33,
41
],
[
42,
48
],
[
48,
49
],
[
49,
54
],
[
55,
64
],
[
65,
69
],
[
70,
75
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[
76,
79
],
[
... | Assessment of the interaction of Portland cement-based materials with blood and tissue fluids using an animal model Portland cement used in the construction industry improves its properties when wet. Since most dental materials are used in a moist environment, Portland cement has been developed for use in dentistry. The first generation material is mineral trioxide aggregate (MTA), used in surgical procedures, thus in contact with blood. The aim of this study was to compare the setting of MTA in vitro and in vivo in contact with blood by subcutaneous implantation in rats. The tissue reaction to the material was also investigated. ProRoot MTA (Dentsply) was implanted in the subcutaneous tissues of Sprague-Dawley rats in opposite flanks and left in situ for 3 months. Furthermore the material was also stored in physiological solution in vitro. At the end of the incubation time, tissue histology and material characterization were performed. Surface assessment showed the formation of calcium carbonate for both environments. The bismuth was evident in the tissues thus showing heavy element contamination of the animal specimen. The tissue histology showed a chronic inflammatory cell infiltrate associated with the MTA. MTA interacts with the host tissues and causes a chronic inflammatory reaction when implanted subcutaneously. Hydration in vivo proceeds similarly to the in vitro model with some differences particularly in the bismuth oxide leaching patterns. |
[
"O",
"B-T103",
"O",
"B-T103",
"I-T103",
"O",
"O",
"B-T098",
"B-T098",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T103",
"O",
"B-T103",
"I-T103",
"O",
"O",
"O",
"O",
"B-T033",
"I-T033",
"O",
"B-T038",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T103",
"O",
"B-T103",
... | [
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0006675",
"db_name": "UMLS"
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{
"db_id": null,
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{
"db_id": "C0042866",
"db_name": "UMLS"
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{
"db_id": "C0042866",
"db_name": "UMLS"
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{
"db_id": null,
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{
... | [
"Low",
"calcium",
"and",
"vitamin",
"D",
"intake",
"in",
"Korean",
"women",
"over",
"50",
"years",
"of",
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"Inadequate",
"calcium",
"and",
"vitamin",
"D",
"intake",
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"a",
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".",
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... | [
[
0,
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],
[
4,
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12,
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16,
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24,
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26,
32
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[
33,
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36,
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[
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49,
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54,
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[
57,
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63,
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[
6... | Low calcium and vitamin D intake in Korean women over 50 years of age Inadequate calcium and vitamin D intake is a possible risk factor of osteoporosis. Our purposes were to estimate calcium and vitamin D intake in Korean women, and to determine associated risk factors for low calcium and vitamin D intake. This is a multicenter, hospital-based, and cross-sectional study on osteoporosis. In this study, 1516 women of 50 years or older were involved. Dietary calcium and vitamin D intake were evaluated using the self-reporting KCAT questionnaire. Average daily calcium intake was 662.8 ± 473.8 mg, and vitamin D intake 9.5 ± 10.7 μg. In multivariate analysis, older age (OR 1.02, 95 % CI 1.00-1.04, p = 0.001), and rural residence (OR 2.43, 95 % CI 1.34-4.43, p = 0.004) were significant risk factors for lower calcium intake, and older age (OR 1.03, 95 % CI 1.02-1.04, p < 0.001), and rural residence (OR 1.85, 95 % CI 1.10-3.11, p < 0.001) were significant risk factors for lower vitamin D intake. About 70 % of women aged 50 years or older had calcium and vitamin D intake below the recommended dietary intake. Older age and rural residence were significant risk factors for lower calcium and vitamin D intake in Korean women. |
[
"O",
"O",
"B-T092",
"I-T092",
"O",
"O",
"O",
"O",
"O",
"B-T062",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T170",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T092",
"B-T103",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
... | [
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C1551301",
"db_name": "UMLS"
},
{
"db_id": "C1551301",
"db_name": "UMLS"
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{
"db_id": null,
"db_name": null
},
{
"db_id": null,
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{
"db_id... | [
"Harmonization",
"of",
"Clinical",
"Laboratory",
"Information",
"-",
"Current",
"and",
"Future",
"Strategies",
"According",
"to",
"a",
"patient",
"-",
"centered",
"viewpoint",
",",
"the",
"meaning",
"of",
"harmonization",
"in",
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"context",
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"laboratory"... | [
[
0,
13
],
[
14,
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[
17,
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[
26,
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],
[
37,
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],
[
49,
50
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[
51,
58
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[
59,
62
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[
63,
69
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[
70,
80
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[
81,
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[
91,
93
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[
94,
95
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[
... | Harmonization of Clinical Laboratory Information - Current and Future Strategies According to a patient -centered viewpoint, the meaning of harmonization in the context of laboratory medicine is that the information should be comparable irrespective of the measurement procedure used and where and/or when a measurement is made. Harmonization represents a fundamental aspect of quality in laboratory medicine as its ultimate goal is to improve patient outcomes through the provision of an accurate and actionable laboratory information. Although the initial focus has to a large extent been to harmonize and standardize analytical processes and methods, the scope of harmonization goes beyond to include all other aspects of the total testing process (TTP), such as terminology and units, report formats, reference intervals and decision limits, as well as tests and test profiles request and criteria for interpretation. Two major progresses have been made in the area of harmonization in laboratory medicine: first, the awareness that harmonization should take into consideration not only the analytical phase but all steps of the TTP, thus dealing with the request, the sample, the measurement, and the report. Second, as the processes required to achieve harmonization are complicated, a systematic approach is needed. The International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) has played a fundamental and successful role in the development of standardized and harmonized assays, and now it should continue to work in the field through the collaboration and cooperation with many other stakeholders. |
[
"B-T062",
"O",
"B-T017",
"I-T017",
"I-T017",
"B-T038",
"I-T038",
"O",
"B-T204",
"I-T204",
"O",
"O",
"O",
"O",
"B-T062",
"O",
"O",
"O",
"B-T058",
"O",
"O",
"O",
"B-T204",
"I-T204",
"I-T204",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T038",
"I-T038",
"O",
"O"... | [
{
"db_id": "C0017387",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C1334098",
"db_name": "UMLS"
},
{
"db_id": "C1334098",
"db_name": "UMLS"
},
{
"db_id": "C1334098",
"db_name": "UMLS"
},
{
"db_id": "C0017262",
"db_name": "U... | [
"Manipulation",
"of",
"IL",
"-",
"10",
"gene",
"expression",
"by",
"Toxoplasma",
"gondii",
"and",
"its",
"products",
"This",
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"to",
"evaluate",
"whether",
"or",
"not",
"T",
".",
"gondii",
"and",
"its",
"derivatives",
"can",
"change... | [
[
0,
12
],
[
13,
15
],
[
16,
18
],
[
18,
19
],
[
19,
21
],
[
22,
26
],
[
27,
37
],
[
38,
40
],
[
41,
51
],
[
52,
58
],
[
59,
62
],
[
63,
66
],
[
67,
75
],
[
... | Manipulation of IL-10 gene expression by Toxoplasma gondii and its products This study was designed to evaluate whether or not T. gondii and its derivatives can change the gene expression level of IL-10 in murine leukocytes in vivo. Fifty BALB/c mice were divided into 5 groups, four of which received the excretory/secretory product (ESP) from cell culture medium, the ESP from cell free medium, the Toxoplasma lysate product (TLP) and the active tachyzoites, respectively. The fifth group was considered as control and received PBS. The peritoneal leukocytes from the mice were collected. Their total RNA were extracted and converted to cDNA and the gene expression level s of IL-10 in the samples were evaluated by quantitative real time-PCR using the REST-2009 software. The findings showed a decrease in the expression level of IL-10 in the TLP group (p=0.004). Moreover, the IL-10 gene expression level weeas upregulated in the group of the ESP from cell culture medium (p=0.04) and the active tachyzoite group (p=0.04). The expression of IL-10 gene in the group of ESP from cell-free medium was not significant compared to the control one (p=0.45). T. gondii and its derivatives are able to increase (the active T. gondii, tachyzoite and the ESP from cell culture medium) and decrease (the TLP) the gene expression level of IL-10 in a murine model. The question remains to be examined in further study about which molecules are involved in this process. |
[
"O",
"O",
"B-T033",
"O",
"B-T058",
"O",
"B-T038",
"I-T038",
"O",
"O",
"O",
"O",
"B-T058",
"I-T058",
"O",
"B-T038",
"I-T038",
"O",
"O",
"O",
"B-T058",
"I-T058",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T038",
"O",
"B-T058",
"O",
"B-T058",
"I-T058",
"... | [
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0011900",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0087111",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id... | [
"PATHOPHYSIOLOGY",
",",
"DIAGNOSIS",
"AND",
"TREATMENT",
"OF",
"DUMPING",
"SYNDROME",
"AND",
"ITS",
"RELATION",
"TO",
"BARIATRIC",
"SURGERY",
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"dumping",
"syndrome",
"is",
"frequent",
"in",
"bariatric",
"surgery",
".",
"It",
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"probably",
"the",
"most"... | [
[
0,
15
],
[
15,
16
],
[
17,
26
],
[
27,
30
],
[
31,
40
],
[
41,
43
],
[
44,
51
],
[
52,
60
],
[
61,
64
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[
65,
68
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[
69,
77
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[
78,
80
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[
81,
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... | PATHOPHYSIOLOGY, DIAGNOSIS AND TREATMENT OF DUMPING SYNDROME AND ITS RELATION TO BARIATRIC SURGERY The dumping syndrome is frequent in bariatric surgery. It is probably the most common syndrome following partial or complete gastrectomy. Its prevalence in partial gastrectomy can reach up to 50%, thus it can be a significant complication arising from some types of bariatric surgeries. Critical analysis on dumping syndrome, its pathophysiology, diagnosis and treatment. A literature review was performed using the key words: ' dumping syndrome ', ' bariatric surgery ' and ' rapid dumping syndrome '. Inclusion criteria were: books, original works, case reports and meta-analyzes, and the exclusion criterion was literature review. Concerning the publication time, articles were screened between 1960 and May 2015. The dumping syndrome is complication arising from obesity surgeries, but also can be a result of vagus nerve damage. Diagnosis is done primarily through the use of questionnaires based on scores. The Sigstad score and Arts survey are valid means for assessing the dumping syndrome. Initial therapy consists in the adoption of dietary measures, short acting drugs administration. A síndrome de dumping é frequente após operações bariátricas. É, provavelmente, a mais comum das síndromes que sucedem gastrectomias parciais ou completas. Sua prevalência, em gastrectomias parciais pode chegar a até 50%, tornando-se assim complicação significante em alguns tipos de operações bariátricas. Realizar análise crítica sobre a síndrome de dumping em sua fisiopatologia, diagnóstico e tratamento. Foi realizada revisão bibliográfica utilizando os descritores: 'síndrome de dumping', 'cirurgia bariátrica' e 'síndrome do esvaziamento rápido'. Os critérios de inclusão foram: livros, trabalhos originais, relatos de caso e metanálises; excluíram-se as revisões bibliográficas. Quanto ao tempo de publicação, foram selecionados artigos entre 1960 e maio de 2015. A síndrome de dumping é complicação gastrointestinal oriunda de operações para obesidade, mas também pode ocasionar-se como consequência de danos no nervo vago. Seu diagnóstico é realizado primordialmente através da aplicação de questionários baseados em pontuações. O escore de Sigstad e questionário de Arts são meios válidos para avaliação da síndrome de dumping. A terapia inicial consiste na adoção de medidas dietéticas, ou fármacos administráveis de ação curta. |
[
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T204",
"I-T204",
"O",
"O",
"O",
"O",
"O",
"B-T038",
"O",
"B-T017",
"O",
"B-T033",
"O",
"B-T204",
"I-T204",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T204",
"I-T204",
"O",
"B-T204",
... | [
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db... | [
"Assessment",
"of",
"the",
"impact",
"of",
"changes",
"in",
"temperature",
"in",
"Biomphalaria",
"glabrata",
"(",
"Say",
",",
"1818",
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"melanic",
"and",
"albino",
"variants",
"infected",
"with",
"Schistosoma",
"mansoni",
"(",
"Sambon",
",",
"1907",
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... | [
[
0,
10
],
[
11,
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],
[
14,
17
],
[
18,
24
],
[
25,
27
],
[
28,
35
],
[
36,
38
],
[
39,
50
],
[
51,
53
],
[
54,
66
],
[
67,
75
],
[
76,
77
],
[
77,
80
],
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... | Assessment of the impact of changes in temperature in Biomphalaria glabrata (Say, 1818) melanic and albino variants infected with Schistosoma mansoni (Sambon, 1907) Fluctuations in population density of planorbid hosts of S. mansoni are influenced by climatic factors. The knowledge about interference from changes in water temperature in these populations is an important aspect of the epidemiology of schistosomiasis. In this experiment, it is explored the influence of different temperatures on the development of Schistosoma mansoni in Biomphalaria glabrata melanic and albino variants. The results indicated an intrinsic relationship between temperature and development of the parasite in the intramollusc phase, independent of the pigmentation of the mantle of the molluscs. The higher the temperature, the shorter the period necessary for the development of the parasite was while the higher the mortality of infected mollusks. It is concluded that, in the presence of climate change, the increasement of temperature in cold and flooded regions may encourage the establishment of new foci of transmission of schistosomiasis by changing the geographic extent and extending the epidemiological transmission potential. In warm climates, higher temperatures, however, could compromise the transmission of the disease because of biological stress suffered by parasite and host. Under these conditions, it can result in the death of the parasite or a change in their ability to infect new host species of molluscs in new areas. Mantle pigmentation patterns in molluscs have not shown significant interference in the development of the parasite. |
[
"O",
"O",
"O",
"B-T170",
"O",
"O",
"O",
"B-T082",
"B-T092",
"O",
"B-T082",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T038",
"B-T058",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T038",
"B-T058",
"O",
"O"... | [
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C1705654",
"db_name": "UMLS"
},
{
"db_id": null,
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{
"db_id": null,
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{
"db_id": null,... | [
"Different",
"modalities",
"of",
"entry",
"in",
"a",
"large",
"urban",
"clinic",
"in",
"Uganda",
"and",
"impact",
"on",
"outcomes",
"of",
"patients",
"assessing",
"HIV",
"care",
"and",
"treatment",
"In",
"resource",
"-",
"limited",
"settings",
",",
"a",
"num... | [
[
0,
9
],
[
10,
20
],
[
21,
23
],
[
24,
29
],
[
30,
32
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[
33,
34
],
[
35,
40
],
[
41,
46
],
[
47,
53
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[
54,
56
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[
57,
63
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[
64,
67
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[
68,
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... | Different modalities of entry in a large urban clinic in Uganda and impact on outcomes of patients assessing HIV care and treatment In resource-limited settings, a number of patients do not receive continuous HIV care. In this analysis, we compared outcomes in patients who entered care by different modality of entry. This was a retrospective analysis of all patients started on antiretroviral treatment (ART) at a large urban center in Uganda from 2005 to 2012. Patients were categorized into three groups (1) Front door: started on ART without interruption during follow-up; (2) drop-out side door: restarted on ART after having an interruption > 6 months and (3) transfer-in side door: transferred-in after being started on ART somewhere else. We compared characteristics at enrollment in the three groups and investigated the following outcomes: (1) retention in care (2) switch to second line. In the study period 11,528 (87.2%) were enrolled through the front door, 1159 (8.7%) resumed ART after dropping out, while 527 (4%) patients were transferred in on ART. The three groups were generally comparable, although patients transferred in were sicker. A larger proportion of patients entered through the drop-out side door died or was lost to follow-up (37.3%), as compared to patients in the front door group (24.9%) and transferred-in side door group (17.7%). More patients in the front door group (32.1%) were transferred out during the follow-up. The highest probability of switching to second line was found in the transferred-in group. Patients who re-enter our program after dropping out are at higher risk of dropping out of care and often need to be switched to second-line ART. The high demand for second-line therapy among patients in transfer-in side door reflects failure in management of complicated patients who are usually require " up-transfer " to better treatment centers. In future understanding, the different modes of entry into HIV care will be key in reshaping the general cascade of HIV care. JOURNAL ART |
[
"O",
"B-T103",
"O",
"O",
"O",
"O",
"O",
"B-T103",
"O",
"O",
"B-T103",
"O",
"O",
"B-T103",
"I-T103",
"O",
"O",
"O",
"O",
"B-T103",
"O",
"O",
"O",
"B-T062",
"I-T062",
"I-T062",
"O",
"B-T058",
"I-T058",
"I-T058",
"O",
"O",
"O",
"B-T103",
"O",
"O",
... | [
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0036140",
"db_name": "UMLS"
},
{
"db_id": null,
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{
"db_id": null,
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},
{
"db_id": null,
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{
"db_id": null,
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{
"db_id": null,... | [
"Unusual",
"Salt",
"and",
"pH",
"Induced",
"Changes",
"in",
"Polyethylenimine",
"Solutions",
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"-",
"transfection",
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[
0,
7
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[
8,
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[
13,
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[
17,
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[
20,
27
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[
28,
35
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[
36,
38
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[
39,
55
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[
56,
65
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[
66,
72
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[
73,
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[
77,
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[
80,
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8... | Unusual Salt and pH Induced Changes in Polyethylenimine Solutions Linear PEI is a cationic polymer commonly used for complexing DNA into nanoparticles for cell-transfection and gene-therapy applications. The polymer has closely-spaced amines with weak-base protonation capacity, and a hydrophobic backbone that is kept unaggregated by intra-chain repulsion. As a result, in solution PEI exhibits multiple buffering mechanisms, and polyelectrolyte states that shift between aggregated and free forms. We studied the interplay between the aggregation and protonation behavior of 2.5 kDa linear PEI by pH probing, vapor pressure osmometry, dynamic light scattering, and ninhydrin assay. Our results indicate that: At neutral pH, the PEI chains are associated and the addition of NaCl initially reduces and then increases the extent of association .The aggregate form is uncollapsed and co-exists with the free chains. PEI buffering occurs due to continuous or discontinuous charging between stalled states. Ninhydrin assay tracks the number of unprotonated amines in PEI .The size of PEI - DNA complexes is not significantly affected by the free vs. aggregated state of the PEI polymer. Despite its simple chemical structure, linear PEI displays intricate solution dynamics, which can be harnessed for environment - sensitive biomaterials and for overcoming current challenges with DNA delivery. |
[
"B-T017",
"O",
"B-T017",
"I-T017",
"I-T017",
"B-T017",
"B-T038",
"O",
"O",
"O",
"O",
"B-T038",
"I-T038",
"O",
"B-T038",
"O",
"O",
"B-T062",
"I-T062",
"O",
"B-T058",
"I-T058",
"I-T058",
"O",
"O",
"B-T038",
"I-T038",
"O",
"B-T038",
"I-T038",
"O",
"O",
"O... | [
{
"db_id": "C0019564",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0018220",
"db_name": "UMLS"
},
{
"db_id": "C0018220",
"db_name": "UMLS"
},
{
"db_id": "C0018220",
"db_name": "UMLS"
},
{
"db_id": "C0007610",
"db_name": "U... | [
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"imaging",
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[
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12,
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16,
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21,
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26,
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33,
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[
40,
47
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[
48,
50
],
[
51,
59
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[
60,
63
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[
64,
74
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[
75,
84
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[
85,
95
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[
... | Hippocampal and Deep Gray Matter Nuclei Atrophy Is Relevant for Explaining Cognitive Impairment in MS: A Multicenter Study The structural MR imaging correlates of cognitive impairment in multiple sclerosis are still debated. This study assessed lesional and atrophy measures of white matter and gray matter involvement in patients with MS acquired in 7 European sites to identify the MR imaging variables most closely associated with cognitive dysfunction. Brain dual-echo, 3D T1-weighted, and double inversion recovery scans were acquired at 3T from 62 patients with relapsing-remitting MS and 65 controls. Patients with at least 2 neuropsychological tests with abnormal findings were considered cognitively impaired. Focal WM and cortical lesions were identified, and volumetric measures from WM, cortical GM, the hippocampus, and deep GM nuclei were obtained. Age - and site -adjusted models were used to compare lesion and volumetric MR imaging variables between patients with MS who were cognitively impaired and cognitively preserved. A multivariate analysis identified MR imaging variables associated with cognitive scores and disability. Twenty-three patients (38%) were cognitively impaired. Compared with those with who were cognitively preserved, patients with MS with cognitive impairment had higher T2 and T1 lesion volumes and a trend toward a higher number of cortical lesions. Significant brain, cortical GM, hippocampal, deep GM nuclei, and WM atrophy was found in patients with MS with cognitive impairment versus those who were cognitively preserved. Hippocampal and deep GM nuclei atrophy were the best predictors of cognitive impairment, while WM atrophy was the best predictor of disability. Hippocampal and deep GM nuclei atrophy are key factors associated with cognitive impairment in MS. These MR imaging measures could be applied in a multicenter context, with cognition as clinical outcome. |
[
"B-T103",
"O",
"O",
"B-T017",
"B-T103",
"O",
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"B-T204",
"B-T038",
"O",
"B-T103",
"O",
"O",
"B-T038",
"I-T038",
"B-T017",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T038",
"I-T038",
"I-T038",
"I-T038",
"O",
"B-T038",
"O",
"O",
"... | [
{
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{
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{
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{
"db_id": "C0667394",
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{
"db_id": null,
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{
... | [
"Simvastatin",
"enhances",
"the",
"hippocampal",
"klotho",
"in",
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77,
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... | Simvastatin enhances the hippocampal klotho in a rat model of streptozotocin - induced cognitive decline Brain oxidative status is a crucial factor in the development of sporadic Alzheimer's disease (AD). Klotho, an anti-aging protein, diminishes oxidative stress by the induction of manganese superoxide dismutase (MnSOD). Thus, the substances that increase klotho expression could be considered as a potential treatment for Alzheimer's disease when the oxidative imbalance is present. Statins are suggested to up-regulate klotho expression. We examined the effect of simvastatin (5mg/kg, daily for 3 weeks) on hippocampal klotho and MnSOD expression in the cognitive declined animal model induced by intracerebroventricular (ICV)- streptozotocin (STZ) administration. Cognitive assessment was performed by the Morris Water Maze (MWM) test. The results indicated that mean escape latency and distance were prolonged in the ICV - STZ group compared with the control group. The expression of klotho and MnSOD were also down regulated in the hippocampus. Furthermore, improved spatial performance was observed in simvastatin - treated animals. This effect could be related to increase in oxidative stress tolerance as evidenced by klotho and MnSOD up-regulation. Our current study indicates that klotho upregulation may be a neuroprotective mechanism of simvastatin against cognitive decline in AD. |
[
"O",
"O",
"O",
"O",
"O",
"B-T058",
"I-T058",
"O",
"O",
"O",
"O",
"B-T204",
"O",
"B-T204",
"O",
"O",
"B-T062",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T058",
"I-T058",
"O",
"O",
"B-T017",
"O",
"O",
"B-T062",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
... | [
{
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{
"db_id": "C0031809",
"db_name": "UMLS"
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{
"db_id": "C003... | [
"Inter",
"-",
"observer",
"agreement",
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"examinations",
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"lesions",
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"hoof",... | [
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0,
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[
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79,... | Inter-observer agreement for clinical examinations of foot lesions of sheep In sheep, the diagnosis of foot lesions is routinely based on physical examination of the hoof. Correct diagnosis is important for the effective treatment, prevention and control of both infectious and non-infectious causes of lameness. Therefore, the aim of this study was to evaluate the level of inter-observer agreement for clinical examination of ovine foot lesions. Eight observers of varying experience, training and occupation performed foot examinations on a total of 1158 sheep from 38 farms across North England and Wales. On each farm, a group of two to four observers independently examined a sample of 24 to 30 sheep to diagnose the presence or absence of specific foot lesions including white line lesions (WL), contagious ovine digital dermatitis (CODD), footrot (FR), inter-digital dermatitis (ID) and toe granuloma (TG). The inter-observer agreement of foot lesion assessments was examined using Fleiss kappa (κ), and Cohen's κ examined the paired agreement between the test standard observer (TSO) and each observer. Scoring differences with the TSO were examined as the percentage of scoring errors and assessed for evidence of systematic scoring bias. With the exception of WL (maximum error rate 33.3%), few scoring differences with the TSO occurred (maximum error rate 3.3%). This suggests that observers can achieve good levels of reliability when diagnosing most of the commonly observed foot conditions associated with lameness in sheep. |
[
"B-T082",
"I-T082",
"I-T082",
"O",
"B-T007",
"I-T007",
"I-T007",
"I-T007",
"I-T007",
"I-T007",
"I-T007",
"I-T007",
"I-T007",
"I-T007",
"I-T007",
"O",
"B-T170",
"B-T007",
"O",
"O",
"O",
"O",
"B-T170",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T082",
"I-T082",
"I-T... | [
{
"db_id": "C0162326",
"db_name": "UMLS"
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{
"db_id": "C0162326",
"db_name": "UMLS"
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{
"db_id": "C0162326",
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{
"db_id": null,
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{
"db_id": "C1275777",
"db_name": "UMLS"
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{
"db_id": "C1275777",
"db_name": "U... | [
"Draft",
"Genome",
"Sequence",
"of",
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"enterica",
"subsp",
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"enterica",
"Serovar",
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... | [
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[
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[
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8... | Draft Genome Sequence of Salmonella enterica subsp. enterica Serovar Orion Strain CRJJGF_00093 (Phylum Gammaproteobacteria) Here, we report a 4.70-Mbp draft genome sequence of Salmonella enterica subsp. enterica serovar Orion strain CRJJGF_00093, isolated from a dog in 2005. |
[
"B-T058",
"O",
"O",
"B-T033",
"O",
"O",
"O",
"B-T170",
"I-T170",
"B-T038",
"I-T038",
"I-T038",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T170",
"I-T170",
"B-T038",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
... | [
{
"db_id": "C0220825",
"db_name": "UMLS"
},
{
"db_id": null,
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{
"db_id": null,
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{
"db_id": "C0449381",
"db_name": "UMLS"
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{
"db_id": null,
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{
"db_id": null,
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{
"db_id... | [
"Evaluation",
"of",
"Periodontal",
"Parameters",
"in",
"Patients",
"with",
"Early",
"Stage",
"Chronic",
"Lymphocytic",
"Leukemia",
"To",
"assess",
"periodontal",
"conditions",
"in",
"patients",
"with",
"early",
"stage",
"CLL",
"and",
"to",
"compare",
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"with",... | [
[
0,
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[
11,
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14,
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[
26,
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37,
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[
40,
48
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[
49,
53
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[
54,
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[
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95,
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... | Evaluation of Periodontal Parameters in Patients with Early Stage Chronic Lymphocytic Leukemia To assess periodontal conditions in patients with early stage CLL and to compare it with the periodontal status of age matched healthy controls and to analyze the relationship between periodontal and hematological parameters in CLL patients. 60 subjects were examined: 30 patients with CLL Rai 0 (test group) and 30 age -matching healthy individuals (control group). The exclusion criteria were: presence of other systemic disease or condition (e.g. diabetes), history of treatment for periodontitis, use of antibiotics during the last 3 months, use of medications. Socio-demographic data were obtained by means of a questionnaire. Participants with at least 8 teeth underwent a full mouth examination assessing API, PBI, PPD, REC and CAL. Medical data for CLL patients were collected from the patients' records, while hematological data were obtained from the hemogram. Difference between groups was statistically significant for age, number of teeth and frequency of dental checkups (p<0.05). Patients with CLL had significantly higher average values of periodontal indices (API 0.81±0.18; PBI 2.72±0.68; PPD 3.40±0.53; REC 1.95±0.87, CAL 4.37±0.80) compared to the control group (API 0.69±0.15; PBI 1.91±0.45; PPD 2.51±0.40; REC 0.99±0.54; CAL 3.00±0.58). The correlation coefficients between age and periodontal indices showed statistically significance between age and REC (r=0.357; p<0.01), and age and CAL (r=0.295; p<0.05). Age was not statistically significant covariate for CAL (F=2.205; p>0.05), only for REC (F=4.601; p<0.05). After the removal of the statistical effect of age, the difference in REC between CLL and control group remained statistically significant (F=19.732; p<0.01; eta(2)=0.287). Statistically significant association between periodontal and hematological parameters in CLL patients was not found (p>0.05). The results of this study showed that patients with CLL had worse periodontal status compared to healthy subjects. Causal relationship between periodontal and hematological parameters was not proved. |
[
"O",
"O",
"O",
"O",
"O",
"O",
"B-T038",
"I-T038",
"I-T038",
"O",
"B-T201",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T038",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",... | [
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{
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{
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{
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{
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{
"db_id": null,
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{
"db_id": "C0343900",
... | [
"Experience",
"of",
"Varied",
"Presentation",
"of",
"Chronic",
"Progressive",
"Disseminated",
"Histoplasmosis",
"in",
"Immunocompetent",
"Patients",
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"A",
"Diagnostic",
"Conundrum",
"We",
"report",
"two",
"cases",
"of",
"chronic",
"progressive",
"disseminated",
"h... | [
[
0,
10
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[
11,
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[
14,
20
],
[
21,
33
],
[
34,
36
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[
37,
44
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[
45,
56
],
[
57,
69
],
[
70,
84
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[
85,
87
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[
88,
103
],
[
104,
112
],
[
112,
113
],
... | Experience of Varied Presentation of Chronic Progressive Disseminated Histoplasmosis in Immunocompetent Patients: A Diagnostic Conundrum We report two cases of chronic progressive disseminated histoplasmosis with unusual and rare clinical picture in a patient with no underlying risk factor. One 50-year-old male, presented with hoarseness of voice, chronic cough, with a history of nonresponding anti-tubercular therapy, revealed mucocutaneous lesions on examination. Fungating vocal cord lesions were visualized on bronchoscopy, raised suspicion of carcinoma. The second case, a 22-year- old female, referred to hospital with suspected vasculitis, with complaints of "off and on" fever with decreased oral intake, arthralgia, who later developed generalized nodular skin eruptions. On investigation, human immunodeficiency virus test was found to be negative in both the cases. Histopathological findings of skin biopsy, adrenal and bone marrow aspirates raised suspicion, whereas fungal cultures confirmed Histoplasma infection. Although diagnosis was delayed, but both of them were successfully treated with amphotericin B. |
[
"O",
"O",
"O",
"O",
"O",
"B-T103",
"I-T103",
"I-T103",
"I-T103",
"B-T058",
"I-T058",
"I-T058",
"O",
"O",
"O",
"O",
"O",
"B-T074",
"I-T074",
"I-T074",
"I-T074",
"O",
"O",
"B-T170",
"I-T170",
"I-T170",
"I-T170",
"I-T170",
"B-T058",
"O",
"O",
"B-T074",
"I... | [
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{
"db_id": "C0303596",
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{
"db_id": "C030... | [
"Optimization",
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"for",
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37,
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[
42,
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[
44,
45
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[
45,
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[
47,
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66,
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... | Optimization of Image Reconstruction for (90)Y Selective Internal Radiotherapy on a Lutetium Yttrium Orthosilicate PET/CT System Using a Bayesian Penalized Likelihood Reconstruction Algorithm Imaging on a γ-camera with (90)Y after selective internal radiotherapy (SIRT) may allow for verification of treatment delivery but suffers relatively poor spatial resolution and imprecise dosimetry calculation. (90)Y PET/CT imaging is possible on 3-dimensional, time-of-flight machines; however, images are usually poor because of low count statistics and noise. A new PET reconstruction software using a Bayesian penalized likelihood (BPL) reconstruction algorithm (termed Q.Clear) was investigated using phantom and patient scans to optimize the reconstruction for post-SIRT imaging and clarify whether BPL leads to an improvement in clinical image quality using (90)Y. Methods: Phantom studies over an activity range of 0.5-4.2 GBq were performed to assess the contrast recovery, background variability, and contrast-to-noise ratio for a range of BPL and ordered-subset expectation maximization (OSEM) reconstructions on a PET/CT scanner. Patient images after SIRT were reconstructed using the same parameters and were scored and ranked on the basis of image quality, as assessed by visual evaluation, with the corresponding SPECT/CT Bremsstrahlung images by 2 experienced radiologists. Results: Contrast-to-noise ratio was significantly better in BPL reconstructions when compared with OSEM in phantom studies. The patient -derived BPL and matching Bremsstrahlung images scored higher than OSEM reconstructions when scored by radiologists. BPL with a β value of 4,000 was ranked the highest of all images. Deadtime was apparent in the system above a total phantom activity of 3.3 GBq. Conclusion: BPL with a β value of 4,000 is the optimal image reconstruction in PET/CT for confident radiologic reading when compared with other reconstruction parameters for (90)Y imaging after SIRT imaging. Activity in the field of view should be below 3.3 GBq at the time of PET imaging to avoid deadtime losses for this scanner. |
[
"B-T058",
"I-T058",
"O",
"O",
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"I-T058",
"I-T058",
"I-T058",
"B-T058",
"B-T033",
"B-T058",
"I-T058",
"B-T098",
"O",
"B-T103",
"I-T103",
"I-T103",
"I-T103",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T058",
"I-T058",
"O",
"O",
"O",
"O",
"O",
... | [
{
"db_id": "C1167938",
"db_name": "UMLS"
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{
"db_id": "C1167938",
"db_name": "UMLS"
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{
"db_id": null,
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{
"db_id": null,
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{
"db_id": "C4084772",
"db_name": "UMLS"
},
{
"db_id": "C4084772",
"db_name": "UMLS"
}... | [
"C1Q",
"Assay",
"Results",
"in",
"Complement",
"-",
"Dependent",
"Cytotoxicity",
"Crossmatch",
"Negative",
"Renal",
"Transplant",
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"Specific",
"Antibodies",
":",
"High",
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"but",
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[
0,
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[
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[
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[
18,
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[
21,
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[
31,
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[
32,
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[
42,
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[
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[
66,
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1... | C1Q Assay Results in Complement-Dependent Cytotoxicity Crossmatch Negative Renal Transplant Candidates with Donor-Specific Antibodies: High Specificity but Low Sensitivity When Predicting Flow Crossmatch The aim of the present study was to describe the association of positive flow cross match (FXM) and C1q-SAB. Methods. In this observational, cross-sectional, and comparative study, patients included had negative AHG-CDC-XM and donor specific antibodies (DSA) and were tested with FXM. All pretransplant sera were tested with C1q-SAB assay. Results. A total of 50 donor / recipient evaluations were conducted; half of them had at least one C1q+ Ab (n = 26, 52%). Ten patients (20.0%) had DSA C1q+ Ab. Twenty-five (50%) FXMs were positive. Factors associated with a positive FXM were the presence of C1q+ Ab (DSA C1q+ Ab: OR 27, 2.80-259.56, P = 0.004, and no DSA C1q+ Ab: OR 5, 1.27-19.68, P = 0.021) and the DSA LABScreen-SAB MFI (OR 1.26, 95% CI 1.06-1.49, P = 0.007). The cutoff point of immunodominant LABScreen SAB DSA - MFI with the greatest sensitivity and specificity to predict FXM was 2,300 (sensitivity: 72% and specificity: 75%). For FXM prediction, DSA C1q+ Ab was the most specific (95.8%, 85-100) and the combination of DSA - MFI > 2,300 and C1q+ Ab was the most sensitive (92.0%, 79.3-100). Conclusions. C1q+ Ab and LABScreen SAB DSA - MFI were significantly associated with FXM. DSA C1q+ Ab was highly specific but with low sensitivity. |
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"B-T103",
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"I-T038",
"O",
"B-T038",
"O",
"O",
"O",
"B-T038",
"O",
"O",
"O",
"B-... | [
{
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"db_id": "C043... | [
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8... | Aberrant LncRNA Expression Profile in a Contusion Spinal Cord Injury Mouse Model Long noncoding RNAs (LncRNAs) play a crucial role in cell growth, development, and various diseases related to the central nervous system. However, LncRNA differential expression profiles in spinal cord injury are yet to be reported. In this study, we profiled the expression pattern of LncRNAs using a microarray method in a contusion spinal cord injury (SCI) mouse model. Compared with a spinal cord without injury, few changes in LncRNA expression levels were noted 1 day after injury. The differential changes in LncRNA expression peaked 1 week after SCI and subsequently declined until 3 weeks after injury. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to validate the reliability of the microarray, demonstrating that the results were reliable. Gene ontology (GO) analysis indicated that differentially expressed mRNAs were involved in transport, cell adhesion, ion transport, and metabolic processes, among others. Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis showed that the neuroactive ligand-receptor interaction, the PI3K - Akt signaling pathway, and focal adhesions were potentially implicated in SCI pathology. We constructed a dynamic LncRNA - mRNA network containing 264 LncRNAs and 949 mRNAs to elucidate the interactions between the LncRNAs and mRNAs. Overall, the results from this study indicate for the first time that LncRNAs are differentially expressed in a contusion SCI mouse model. |
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... | Copolymer Brush -Based Ultralow-Fouling Biorecognition Surface Platform for Food Safety Functional polymer coatings that combine the ability to resist nonspecific fouling from complex media with high biorecognition element (BRE) immobilization capacity represent an emerging class of new functional materials for a number of bioanalytical and biosensor technologies for medical diagnostics, security, and food safety. Here, we report on a random copolymer brush surface - poly(CBMAA-ran-HPMAA) - providing high BRE immobilization capacity while simultaneously exhibiting ultralow-fouling behavior in complex food media. We demonstrate that both the functionalization and fouling resistance capabilities of such copolymer brushes can be tuned by changing the surface contents of the two monomer units: nonionic N-(2-hydroxypropyl) methacrylamide (HPMAA) and carboxy-functional zwitterionic carboxybetaine methacrylamide (CBMAA). It is demonstrated that the resistance to fouling decreases with the surface content of CBMAA; poly(CBMAA-ran-HPMAA) brushes with CBMAA molar content up to 15 mol % maintain excellent resistance to fouling from a variety of homogenized foods (hamburger, cucumber, milk, and lettuce) even after covalent attachment of BREs to carboxy groups of CBMAA. The poly(CBMAA 15 mol %-ran-HPMAA) brushes functionalized with antibodies are demonstrated to exhibit fouling resistance from food samples by up to 3 orders of magnitude better when compared with the widely used low-fouling carboxy-functional oligo(ethylene glycol) (OEG)-based alkanethiolate self-assembled monolayers (AT SAMs) and, furthermore, by up to 2 orders of magnitude better when compared with the most successful ultralow-fouling biorecognition coatings - poly(carboxybetaine acrylamide), poly(CBAA). When model SPR detections of food-borne bacterial pathogens in homogenized foods are used, it is also demonstrated that the antibody - functionalized poly(CBMAA 15 mol %-ran-HPMAA) brush exhibits superior biorecognition properties over the poly(CBAA). |
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... | [
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... | Computational Modeling of β-Secretase 1 (BACE-1) Inhibitors Using Ligand Based Approaches The binding affinities (IC50) reported for diverse structural and chemical classes of human β-secretase 1 (BACE-1) inhibitors in literature were modeled using multiple in silico ligand based modeling approaches and statistical techniques. The descriptor space encompasses simple binary molecular fingerprint, one - and two-dimensional constitutional, physicochemical, and topological descriptors, and sophisticated three-dimensional molecular fields that require appropriate structural alignments of varied chemical scaffolds in one universal chemical space. The affinities were modeled using qualitative classification or quantitative regression schemes involving linear, nonlinear, and deep neural network (DNN) machine-learning methods used in the scientific literature for quantitative-structure activity relationships (QSAR). In a departure from tradition, ∼20% of the chemically d iverse data set (205 compounds) was used to train the model with the remaining ∼80% of the s tructural and chemical analogs used as part of an external validation (1273 compounds) and prospective test (69 compounds) sets respectively to ascertain the model performance. The machine-learning methods investigated herein performed well in both the qualitative classification (∼70% accuracy) and quantitative IC50 predictions (RMSE ∼ 1 log). The success of the 2D descriptor based machine learning approach when compared against the 3D field based technique pursued for hBACE-1 inhibitors provides a strong impetus for systematically applying such methods during the lead identification and optimization efforts for other protein families as well. |
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... | [
"Safe",
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7... | Safe Routes to Play? Pedestrian and Bicyclist Crashes Near Parks in Los Angeles Areas near parks may present active travelers with higher risks than in other areas due to the confluence of more pedestrians and bicyclists, younger travelers, and the potential for increased traffic volumes. These risks may be amplified in low-income and minority neighborhoods due to generally higher rates of active travel or lack of safety infrastructure. This paper examines active travel crashes near parks and builds on existing research around disparities in park access and extends research from the Safe Routes to School and Safe Routes to Transit movements to parks. We utilized the Green Visions Parks coverage, encompassing Los Angeles County and several other cities in the LA Metropolitan area. We used negative bionomial regression modeling techniques and ten years of geolocated pedestrian and bicyclist crash data to assess the number of active travel injuries within a quarter mile (~400m) buffer around parks. We controlled for differential exposures to active travel using travel survey data and Bayesian smoothing models. Of 1,311,736 parties involved in 608,530 crashes, there were 896,359 injuries and 7317 fatalities. The number of active travel crash injuries is higher within a quarter-mile of a park, with a ratio of 1.52 per 100,000 residents, compared to areas outside that buffer. This higher rate near parks is amplified in neighborhoods with high proportions of minority and low-income residents. Higher traffic levels are highly predictive of active travel crash injuries. Planners should consider the higher risks of active travel near parks and the socioeconomic modification of these risks. Additional traffic calming and safety infrastructure may be needed to provide safe routes to parks. |
[
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... | [
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... | [
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90,... | l-Arginine Enhances Resistance against Oxidative Stress and Heat Stress in Caenorhabditis elegans The antioxidant properties of l-arginine (l-Arg) in vivo, and its effect on enhancing resistance to oxidative stress and heat stress in Caenorhabditis elegans were investigated. C. elegans, a worm model popularly used in molecular and developmental biology, was used in the present study. Here, we report that l-Arg, at a concentration of 1 mM, prolonged C. elegans life by 26.98% and 37.02% under oxidative and heat stress, respectively. Further experiments indicated that the longevity -extending effects of l-Arg may be exerted by its free radical scavenging capacity and the upregulation of aging -associated gene expression in worms. This work is important in the context of numerous recent studies that concluded that environment stresses are associated with an increased population death rate. |
[
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"O",
"... | [
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... | [
"Systemic",
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8... | Systemic Collyriclum faba (Trematoda: Collyriclidae) Infection in a Wild Common Raven (Corvus corax) A hatch-year Common Raven (Corvus corax) with subcutaneous and internal pseudocysts, filled with fluid, containing a pair of adult trematodes and numerous eggs consistent with Collyriclum faba, died near a riverbank in California, US. While C. faba is incidental in many Passeriformes, this case was a fatal systemic infection. |
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"O",
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"O... | [
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... | [
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... | Determinants of Engagement in Leisure-time Physical Activity - Dialogue with Senior Athletes This article explores the factors determining whether older adults engage in the Senior Games and related leisure-time physical activity through examining the adults ' salient beliefs. We conducted 10 in-depth interviews with older adults who have participated in the Senior Games. Underpinned by the planned behavior theory's framework, we explored three types of beliefs: advantages and disadvantages (behavioral beliefs), social support and pressure (normative beliefs), and facilitators and impediments (control beliefs). Interview respondents were found to engage in the Senior Games and related physical activity to the extent that they associated various intangible advantages with the games and valued psychological satisfaction. They viewed their peers and families as supporting and approving of their engagement and recognized the physical capabilities required, and structural constraints necessary, to engage in the games and related activity. With these findings, pertinent beliefs can be combined with interventions designed to encourage leisure-time physical activities by older adults. |
[
"B-T038",
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"O",
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{
"db_id": "C0011854",
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9... | Sleep characteristics in type 1 diabetes and associations with glycemic control: systematic review and meta-analysis The association between inadequate sleep and type 2 diabetes has garnered much attention, but little is known about sleep and type 1 diabetes (T1D). Our objectives were to conduct a systematic review and meta-analysis comparing sleep in persons with and without T1D, and to explore relationships between sleep and glycemic control in T1D. Studies were identified from Medline and Scopus. Studies reporting measures of sleep in T1D patients and controls, and/or associations between sleep and glycemic control, were selected. A total of 22 studies were eligible for the meta-analysis. Children with T1D had shorter sleep duration (mean difference [MD] = -26.4 minutes; 95% confidence interval [CI] = -35.4, -17.7) than controls. Adults with T1D reported poorer sleep quality (MD in standardized sleep quality score = 0.51; 95% CI = 0.33, 0.70), with higher scores reflecting worse sleep quality) than controls, but there was no difference in self - reported sleep duration. Adults with TID who reported sleeping >6 hours had lower hemoglobin A1c (HbA1c) levels than those sleeping ≤6 hours (MD = -0.24%; 95% CI = -0.47, -0.02), and participants reporting good sleep quality had lower HbA1c than those with poor sleep quality (MD = -0.19%; 95% CI = -0.30, -0.08). The estimated prevalence of obstructive sleep apnea (OSA) in adults with TID was 51.9% (95% CI = 31.2, 72.6). Patients with moderate-to-severe OSA had a trend toward higher HbA1c (MD = 0.39%, 95% CI = -0.08, 0.87). T1D was associated with poorer sleep and high prevalence of OSA. Poor sleep quality, shorter sleep duration, and OSA were associated with suboptimal glycemic control in T1D patients. |
[
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"... | [
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"db_id": null,
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},
{
"db_id... | [
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"replacements",
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"young",
"adults",
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":",
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[
0,
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6,
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19,
21
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22,
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28,
34
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35,
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[
40,
46
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47,
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77,
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84,
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8... | Tooth replacements in young adults with severe hypodontia: Orthodontic space closure, dental implants, and tooth -supported fixed dental prostheses. A follow-up study Children with severe hypodontia have a substantial impairment of their dental health starting early in life. The purpose of this study was to describe types and locations of substitutes for missing teeth in patients with severe hypodontia and to compare the crown and soft tissue morphologies of orthodontic space closure, dental implants, and tooth -supported fixed dental prostheses for replacing teeth in the anterior region. Fifty patients missing 6 or more teeth and aged 18 years or older (mean age, 25.6 years) took part in a follow-up study. The patients were examined clinically with panoramic radiographs and clinical photographs. Crown and soft tissue variables (mucosal discoloration, crown morphology, color, and papilla index) were compared for orthodontic space closure, dental implant fixtures, and fixed dental prostheses. Dental implants, orthodontic space closure, and retaining deciduous teeth were the most commonly prescribed treatments. Persisting deciduous teeth showed a good survival rate at the follow-up examination. Mucosal discoloration was seen only for implant fixtures and was evident for almost all fixtures in the anterior mandible and two thirds of those in the anterior maxilla. The papilla index scored poorer for both implant fixtures and fixed dental prostheses compared with orthodontic space closure. Dental implants in the anterior region proved to be an inadequate treatment modality in patients with severe hypodontia because of pronounced mucosal discoloration. |
[
"O",
"O",
"O",
"B-T103",
"B-T103",
"O",
"B-T103",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T037",
"B-T103",
"O",
"B-T103",
"O",
"O",
"O",
"O",
"B-T103",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"... | [
{
"db_id": null,
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"db_id": null,
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{
"db_id": null,
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"db_id": "C0046343",
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{
"db_id": "C0444414",
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{
"db_id": null,
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{
"db_id... | [
"Effective",
"degradation",
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"methylisothiazolone",
"biocide",
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"ozone",
":",
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",",
"mechanisms",
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"MIT",
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"common",
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"... | [
[
0,
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25,
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45,
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53,
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59,
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64,
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66,
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74,
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76,
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86,
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88,
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... | Effective degradation of methylisothiazolone biocide using ozone: Kinetics, mechanisms, and decreases in toxicity Methylisothiazolone (MIT) is a common biocide that is widely used in water-desalination reverse-osmosis processes. The transformation of MIT during water treatment processes is poorly understood. The kinetics and mechanisms involved in the degradation of MIT during ozonation were investigated in this study. Ozonation was found to be a useful way of degrading MIT in water, and the degradation rate constant was 0.11 (±0.1) × 10(3) L/(mol·s). The degradation rate constant did not change when the pH was increased from 3 to 9. The pre-exponential factor A and the activation energy Ea for the ozonation process were 7.564 × 10(13) L/(mol·s) and 66.74 kJ/mol, respectively. The decrease in the MIT concentration and the amount of ozone consumed were measured, and the stoichiometric factor α for the ozone consumption to MIT removal ratio was found to be 1.8. Several ozonation products were detected using time-of-flight mass spectrometry. Almost 32% of the organic sulfur in the MIT was oxidized to release sulfate ions, which caused a decrease in pH. Sulfur atoms were oxidized to sulfone species and then h ydrolyzed to give sulfate during ozonation. Addition reactions involving carbon-carbon double bonds and the oxidation of α-carbon atoms also occurred. MIT was found to be lethal to Daphnia magna Straus (D. magna) with a median lethal concentration of 18.2 μmol/L. Even though the primary ozonation products of MIT still showed some toxicity to D. magna, ozone could minimize the toxic effect after a long reaction time. |
[
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T033",
"O",
"B-T038",
"I-T038",
"I-T038",
"I-T038",
"O",
"O",
"B-T017",
"I-T017",
"O",
"B-T017",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-... | [
{
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"db_id": null,
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{
"db_id": null,
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{
"db_id": null,
"db... | [
"Effect",
"of",
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",",
"exercise",
"withdrawal",
",",
"and",
"continued",
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"on",
"excitability",
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"mediates",
"beneficial",... | [
[
0,
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[
7,
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[
18,
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[
20,
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29,
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[
39,
40
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[
41,
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[
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[
55,
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75,
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88... | Effect of exercise, exercise withdrawal, and continued regular exercise on excitability and long-term potentiation in the dentate gyrus of hippocampus Exercise mediates beneficial effects on the brain function and neural health, particularly in the hippocampus as the main area of memory. The hippocampus is a structure involved in exercise, which can improve synaptic plasticity and long-term potentiation (LTP). The present study investigated the effect of exercise, exercise withdrawal, and continued regular exercise on excitability and long-term potentiation in the dentate gyrus (DG) of hippocampus. Fifty male Wistar rats were randomly allocated to the five control, sham, exercise, exercise withdrawal, and continued regular exercise treatments. The experimental animals were forced to run on a treadmill one hour a day at a speed of 20-21m/min over the two experimental periods of 21 and 42 days. While stimulating the medial perforant pathway, input-output (I/O) functions and LTP were recorded from the DG to evaluate synaptic potency and plasticity. The relevant responses in the DG were evaluated in all the groups from the slope and PS amplitude of the fEPSP. Results showed that the 21- day exercise treatment increased both the responsiveness and LTP in the DG of hippocampus. A 21- day withdrawal period after the exercise impaired the beneficial effects of the exercise, indicating the reversibility of these exercise - related hippocampal changes. Significant enhancements were also observed in cell responsiveness and LTP with the continued regular exercise (42- day) treatment. |
[
"O",
"O",
"O",
"B-T103",
"I-T103",
"O",
"B-T103",
"I-T103",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T062",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T168",
"I-T168",
"O",
"O",
"O",
"B-T062",
"O",
"O",
"O",
"O",
"O",
"O"... | [
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
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},
{
"db_id": null,
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},
{
"db_id": "C0076733",
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{
"db_id": "C0076733",
"db_name": "UMLS"
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{
"db_id": null,
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{
"db_id... | [
"Toxicity",
"mechanism",
"of",
"titanium",
"dioxide",
"and",
"zinc",
"oxide",
"nanoparticles",
"against",
"food",
"pathogens",
"Food",
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"an",
"important",
"field",
"of",
"research",
".",
"It",
"extends",
"the",
"shelf",
"life",
"of",
"major"... | [
[
0,
8
],
[
9,
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],
[
19,
21
],
[
22,
30
],
[
31,
38
],
[
39,
42
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[
43,
47
],
[
48,
53
],
[
54,
67
],
[
68,
75
],
[
76,
80
],
[
81,
90
],
[
91,
95
],
[
9... | Toxicity mechanism of titanium dioxide and zinc oxide nanoparticles against food pathogens Food preservation is an important field of research. It extends the shelf life of major food products. Our current study is based on food preservation through TiO2 and ZnO nanoparticles. TiO2 and ZnO are biocompatible nanomaterial. The biocompatibility of the materials were established through toxicity studies on cell lines. Titanium dioxide and Zinc Oxide nanoparticle were synthesized by wet chemical process. They are characterized by X-Ray diffraction and TEM. The antibacterial activities of both the materials were analysed to ensure their effectiveness as food preservative against Salmonella typhi, Klebsiella pneumoniae and Shigella flexneri. The results indicates that TiO2 and ZnO nanoparticle inhibits Salmonella, Klebsiella and Shigella. The mode of action is by the generation of ROS in cases of Salmonella, Klebsiella. Mode of action in Shigella is still unclear. It was also proved that TiO2 and ZnO nanoparticle are biocompatible materials. |
[
"O",
"B-T058",
"I-T058",
"O",
"O",
"B-T098",
"I-T098",
"B-T038",
"I-T038",
"O",
"B-T058",
"B-T038",
"I-T038",
"O",
"O",
"O",
"O",
"B-T062",
"O",
"B-T058",
"O",
"O",
"B-T058",
"O",
"B-T038",
"O",
"O",
"B-T058",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"... | [
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0344211",
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},
{
"db_id": "C0344211",
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},
{
"db_id": null,
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},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0085756",
"db_name": "UMLS"
},
{
... | [
"Understanding",
"Supportive",
"Care",
"Factors",
"Among",
"African",
"American",
"Breast",
"Cancer",
"Survivors",
"Comprehensive",
"breast",
"cancer",
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"only",
"diagnosis",
",",
"staging",
",",
"and",
"treatment",
"of",
"cancer",
"but",
... | [
[
0,
13
],
[
14,
24
],
[
25,
29
],
[
30,
37
],
[
38,
43
],
[
44,
51
],
[
52,
60
],
[
61,
67
],
[
68,
74
],
[
75,
84
],
[
85,
98
],
[
99,
105
],
[
106,
112
],
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... | Understanding Supportive Care Factors Among African American Breast Cancer Survivors Comprehensive breast cancer care includes not only diagnosis, staging, and treatment of cancer but also assessment and management of the physical, psychological, social, and informational needs, collectively known as supportive care. Several studies have documented the importance of addressing supportive care factors among breast cancer survivors. However, there appears to be a paucity of research concerning African American breast cancer survivors (AABCS). Therefore, the purpose of this study was to describe and understand the patient-centered supportive care factors among self-identified AABCS. Using a qualitative descriptive approach, an open-ended question explored supportive care factors that were used by N = 155 AABCS. Four supportive care factors were identified: faith, supportive structures, optimism, and access to information. An understanding of these factors might facilitate discussion between survivors and the health care team. The resultant effect could also inform and promote the delivery of culturally specific health care to address the supportive care needs among these women. |
[
"B-T058",
"I-T058",
"O",
"B-T038",
"I-T038",
"O",
"B-T082",
"I-T082",
"I-T082",
"O",
"B-T082",
"O",
"B-T082",
"O",
"O",
"O",
"B-T092",
"O",
"O",
"B-T062",
"I-T062",
"O",
"O",
"O",
"B-T062",
"I-T062",
"O",
"B-T058",
"I-T058",
"O",
"O",
"O",
"O",
"O",
... | [
{
"db_id": "C1513388",
"db_name": "UMLS"
},
{
"db_id": "C1513388",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0009450",
"db_name": "UMLS"
},
{
"db_id": "C0009450",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
}... | [
"Molecular",
"diagnosis",
"of",
"infectious",
"diseases",
"in",
"São",
"Miguel",
"Island",
"(",
"Azores",
",",
"Portugal",
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"based",
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"d... | [
[
0,
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[
10,
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[
20,
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[
23,
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[
34,
42
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[
43,
45
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[
46,
49
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[
50,
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[
57,
63
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[
64,
65
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[
65,
71
],
[
71,
72
],
[
73,
81
],
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... | Molecular diagnosis of infectious diseases in São Miguel Island (Azores, Portugal): A hospital -based descriptive study We performed a descriptive analysis of molecular diagnosis of infectious agents in the São Miguel Island population, in order to address questions like what is the frequency of clinical requests, is it observable seasonality of pathogens, and what is the positive rate for the clinical diagnosis. This was a retrospective and descriptive study based on 878 individuals suspected of harboring infectious diseases during two consecutive years, 2012-2013. More than 25 different pathogens were investigated by polymerase chain reaction (PCR)-based methods. The individuals were stratified into gender, occupation, and age groups. The pathogen with more clinical requests was hepatitis C virus, investigated in 225 individuals (30.0%), followed by Leptospira spp ., in 187 (24.9%). Overall, data demonstrated a gender distribution bias, where 72.9% of cases were males. The age group of 25 to 44 years was the class with more clinical requests. Regarding occupation, a predominance of construction workers (12.0%) was observed, followed by retired workers (11.0%). Patient distribution per year showed a higher number of patients in the fall months. Diagnoses of leptospirosis and respiratory virus infections presented seasonality. The present study provides a valid contribution to the knowledge of the epidemiology of infectious diseases in the São Miguel Island (Azores, Portugal) population. |
[
"O",
"O",
"O",
"B-T103",
"I-T103",
"O",
"B-T074",
"O",
"B-T103",
"B-T074",
"O",
"O",
"B-T038",
"O",
"B-T038",
"I-T038",
"O",
"B-T017",
"O",
"B-T037",
"I-T037",
"B-T103",
"I-T103",
"O",
"B-T103",
"O",
"O",
"O",
"O",
"O",
"B-T103",
"I-T103",
"I-T103",
... | [
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
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},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0142812",
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{
"db_id": "C0142812",
"db_name": "UMLS"
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{
"db_id": null,
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{
"db_id... | [
"Low",
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"of",
"Sodium",
"Butyrate",
"from",
"Ultrabraid",
"+",
"NaBu",
"suture",
",",
"Promotes",
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"bones",
"Injury",
"Sodium",
"butyrate",
"(",
"NaBu",
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",",
"a",
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... | [
[
0,
3
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[
4,
17
],
[
18,
20
],
[
21,
27
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[
28,
36
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[
37,
41
],
[
42,
52
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[
53,
54
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[
55,
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[
60,
66
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[
66,
67
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68,
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77,
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9... | Low Concentration of Sodium Butyrate from Ultrabraid + NaBu suture, Promotes Angiogenesis and Tissue Remodelling in Tendon - bones Injury Sodium butyrate (NaBu), a form of short-chain fatty acid (SCFA), acts classically as a potent anti-angiogenic agent in tumour angiogenesis models, some authors demonstrated that low concentrations of NaBu may contribute to healing of tendon - bone injury in part at least through promotion of tissue remodelling. Here, we investigated the effects of low -range concentrations of NaBu using in vitro and in vivo assays using angiogenesis as the primary outcome measure and the mechanisms through which it acts. We demonstrated that NaBu, alone or perfused from the UltraBraid + NaBu suture was pro-angiogenic at very low -range doses promoting migration, tube formation and cell invasion in bovine aortic endothelial cells (BAECs). Furthermore, cell exposure to low NaBu concentrations increased expression of proteins involved in angiogenic cell signalling, including p-PKCβ1, p-FAK, p-ERK1 / 2, p-NFκβ, p-PLCγ1 and p-VEGFR2. In addition, inhibitors of both VEGFR2 and PKCβ1 blocked the angiogenic response. In in vivo assays, low concentrations of NaBu induced neovascularization in sponge implants in mice, evidenced by increased numbers of vessels and haemoglobin content in these implants. The findings in this study indicate that low concentrations of NaBu could be an important compound to stimulate angiogenesis at a site where vasculature is deficient and healing is compromised. |
[
"B-T058",
"I-T058",
"I-T058",
"I-T058",
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"B-T058",
"I-T058",
"I-T058",
"I-T058",
"B-T038",
"I-T038",
"I-T038",
"I-T038",
"I-T038",
"I-T038",
"I-T038",
"O",
"B-T058",
"O",
"B-T103",
"I-T103",
"I-T103",
"I-T103",
"I-T103",
"O",
"O",
"O",
"O",
"O",
"B-T058"... | [
{
"db_id": "C2609068",
"db_name": "UMLS"
},
{
"db_id": "C2609068",
"db_name": "UMLS"
},
{
"db_id": "C2609068",
"db_name": "UMLS"
},
{
"db_id": "C2609068",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0015252",
"db_name": "U... | [
"Limb",
"-",
"salvage",
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"of",
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"-",
"polyethylene",
"tibial",
"component",
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"a",
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"-",
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[
0,
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[
4,
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[
5,
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],
[
13,
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23,
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[
26,
28
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[
28,
29
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[
29,
34
],
[
35,
43
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[
26,
28
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[
28,
29
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[
29,
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[
35,
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44,... | Limb-salvage treatment of en-block resected distal femoral tumors with endoprosthesis of all-polyethylene tibial component: a 9-year follow-up study To evaluate the medium-term outcome of limb-salvage surgery using all- polyethylene tibial endoprosthetic replacement following en-block resection for distal femoral tumors. Forty-nine patients with distal femoral tumor were treated between June 2006 and June 2012. The follow-up period was 6-110 months (average 53.4 months). The prosthetic survival was analyzed using the Kaplan-Meier method. The classification of failure of limb salvage after reconstructive surgery for bone tumors was adapted. Limb function was evaluated with the scoring system of the Musculoskeletal Tumor Society (MSTS). Complications were observed in six cases (12.2%). Four suffered infection around the prosthesis, of which two cases were treated with debridement, drainage, and antibiotics without removal of the prosthesis, and the other two cases underwent amputation. Two cases were identified as radiographically loose at 7 year follow-up and did not require revision surgery. One patient underwent amputation due to local recurrence. Failure of limb salvage occurred in nine cases (18.4%), of which two cases were of type 1A, two cases of type 2B, three cases of type 4A, one case of type 4B, and one case of type 5A. The mean MSTS score was 84.3%. Twelve cases died due to distant metastases (24.5%), and the average survival time for these patients was 13.5 months. Thirty-seven patients survived (75.5%), for whom the average follow-up time was 66.3 months and the 5-year prosthetic survival rate was 88.2%. The outcome of medium-term and long-term clinical follow-up was satisfactory. All- polyethylene tibial endoprosthetic replacement following en-block resection can be an alternative method of limb salvage for distal femoral tumors. |
[
"O",
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"B-T038",
"I-T038",
"O",
"B-T103",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T038",
"I-T038",
"O",
"O",
"B-T033",
"O",
"O",
"B-T038",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T103",
"B-T103",
"O",
"B-T103",
"O",
"O",
"O",
"B-T038",... | [
{
"db_id": null,
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{
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{
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... | [
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9... | The correlation between CYP2D6 isoenzyme activity and haloperidol efficacy and safety profile in patients with alcohol addiction during the exacerbation of the addiction Today, it is proved that isoenzymes CYP2D6 and CYP3A4 are involved in metabolism of haloperidol. In our previous investigation, we found a medium correlation between the efficacy and safety of haloperidol and the activity of CYP3A4 in patients with alcohol abuse. The aim of this study was to evaluate the correlation between the activity of CYP2D6 and the efficacy and safety of haloperidol in patients with diagnosed alcohol abuse. The study involved 70 men (average age: 40.83±9.92 years) with alcohol addiction. A series of psychometric scales were used in the research. The activity of CYP2D6 was evaluated by high-performance liquid chromatography with mass spectrometry using the ratio of 6-hydroxy-1,2,3,4-tetrahydro-beta-carboline to pinoline. Genotyping of CYP2D6 (1846G>A) was performed using real-time polymerase chain reaction. According to results of correlation analysis, statistically significant values of Spearman correlation coefficient (rs) between the activity of CYP2D6 and the difference of points in psychometric scale were obtained in patients receiving haloperidol in injection form (Sheehan Clinical Anxiety Rating Scale =-0.721 [P<0.001] and Udvald for Kliniske Undersogelser Side Effect Rating Scale =0.692 [P<0.001]) and in those receiving haloperidol in tablet form (Covi Anxiety Scale =-0.851 [P<0.001] and Udvald for Kliniske Undersogelser Side Effect Rating Scale =0.797 [P<0.001]). This study demonstrated the correlations between the activity of CYP2D6 isozyme and the efficacy and safety of haloperidol in patients with alcohol addiction. |
[
"O",
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7... | Time trends in the health care burden and mortality of acute on chronic liver failure in the United States Acute on chronic liver failure (ACLF) is associated with multisystem organ failure and poor prognosis in hospitalized patients with cirrhosis. We aimed to determine time trends in the epidemiology, economic burden, and mortality of ACLF in the United States. The National Inpatient Sample database was queried between 2001 and 2011. ACLF was defined as two or more extrahepatic organ failures in patients with cirrhosis. The primary outcomes were trends in hospitalizations, hospital costs, and inpatient mortality. The number of hospitalizations for cirrhosis in the United States nearly doubled from 371,000 in 2001 to 659,000 in 2011. The prevalence of ACLF among those hospitalizations increased from 1.5% (n = 5,400) to 5% (n = 32,300). The inpatient costs increased 2-fold for cirrhosis ($4.8 billion to $9.8 billion) and 5-fold ($320 million to $1.7 billion) for ACLF. In 2011, the cost per hospitalization for ACLF was 3.5-fold higher than that for cirrhosis ($53,570 versus $15,193). The in-hospital fatality rates decreased from 65% to 50% for ACLF and from 10% to 7% for cirrhosis. The organ failure trends in ACLF showed an increasing proportion of cardiovascular and cerebral and decreasing proportion of respiratory and renal failure. Age, male sex, and the number and types of organ failure were predictors of death in ACLF. Cirrhosis and ACLF represent a substantial and increasing health and economic burden in the United States; these data highlight an urgent need for research on pathophysiological mechanisms and effective therapy as well as for education of health care providers of its importance in the care of patients with cirrhosis. (Hepatology 2016). |
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... | Highly polygenic architecture of antidepressant treatment response: Comparative analysis of SSRI and NRI treatment in an animal model of depression Response to antidepressant (AD) treatment may be a more polygenic trait than previously hypothesized, with many genetic variants interacting in yet unclear ways. In this study we used methods that can automatically learn to detect patterns of statistical regularity from a sparsely distributed signal across hippocampal transcriptome measurements in a large-scale animal pharmacogenomic study to uncover genomic variations associated with AD. The study used four inbred mouse strains of both sexes, two drug treatments, and a control group (escitalopram, nortriptyline, and saline). Multi-class and binary classification using Machine Learning (ML) and regularization algorithms using iterative and univariate feature selection methods, including InfoGain, mRMR, ANOVA, and Chi Square, were used to uncover genomic markers associated with AD response. Relevant genes were selected based on Jaccard distance and carried forward for gene-network analysis. Linear association methods uncovered only one gene associated with drug treatment response. The implementation of ML algorithms, together with feature reduction methods, revealed a set of 204 genes associated with SSRI and 241 genes associated with NRI response. Although only 10% of genes overlapped across the two drugs, network analysis shows that both drugs modulated the CREB pathway, through different molecular mechanisms. Through careful implementation and optimisations, the algorithms detected a weak signal used to predict whether an animal was treated with nortriptyline (77%) or escitalopram (67%) on an independent testing set. The results from this study indicate that the molecular signature of AD treatment may include a much broader range of genomic markers than previously hypothesized, suggesting that response to medication may be as complex as the pathology. The search for biomarkers of antidepressant treatment response could therefore consider a higher number of genetic markers and their interactions. Through predominately different molecular targets and mechanisms of action, the two drugs modulate the same Creb1 pathway which plays a key role in neurotrophic responses and in inflammatory processes. © 2016 The Authors. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics Published by Wiley Periodicals, Inc. |
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... | Formation of an Intraretinal Fluid Barrier in Cavitary Optic Disc Maculopathy Cavitary optic disc maculopathy develops when fluctuating pressure gradients along anomalous communications in the optic nerve head induce migration of fluid into the adjacent retinal tissue. We sought to determine whether carefully titrated laser photocoagulation combined with vitrectomy and gas tamponade can safely create an effective intraretinal barrier to fluid egress from the optic disc cavitation. Retrospective interventional case series. We retrospectively evaluated medical records and imaging studies of 22 consecutive patients with cavitary disc maculopathy evaluated by a single surgeon between 1991 and 2014. Patients requiring surgery underwent carefully titrated juxtapapillary laser photocoagulation followed immediately by vitrectomy and gas tamponade. Main outcome measures were change in visual acuity, macular fluid resolution, and recurrence of maculopathy. Eleven patients (11 eyes) had undergone vitreous surgery and were included in the study. No preoperative evidence for vitreous traction on the optic disc or macula was seen in any eye. Nine patients underwent a single surgery and 2 patients required additional procedures to resolve the macular fluid. Mean length of follow-up after the last surgery was 48.2 months (range, 4-143 months). All 11 patients (100%) had complete resolution of macular fluid, with an average time to resolution of 8.5 months (range, 1-18 months). Only 1 of 11 patients (9%) had recurrence of macular fluid (14 months postoperatively). The average preoperative visual acuity of 20/125 (logMAR 0.81, standard deviation [SD] = 0.36) improved by nearly 4 lines to an average final visual acuity of 20/57 (logMAR 0.45, SD = 0.37) (P = .0072). A possible laser - induced central scotoma was suspected in only 1 patient who had undergone extensive prior laser treatments. An effective intraretinal barrier to fluid migration from cavitary optic disc anomalies can be safely achieved in most patients with carefully titrated juxtapapillary laser photocoagulation combined with vitrectomy and gas tamponade. Once achieved, the barrier facilitates resolution of macular fluid and long-term avoidance of recurrent maculopathy. |
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"... | [
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... | [
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... | Structural Insight into Recognition of Methylated Histone H3K4 by Set3 The plant homeodomain (PHD) finger of Set3 binds methylated lysine 4 of histone H3 in vitro and in vivo; however, precise selectivity of this domain has not been fully characterized. Here, we explore the determinants of methyllysine recognition by the PHD fingers of Set3 and its orthologs. We use X-ray crystallographic and spectroscopic approaches to show that the Set3 PHD finger binds di- and trimethylated states of H3K4 with comparable affinities and employs similar molecular mechanisms to form complexes with either mark. Composition of the methyllysine - binding pocket plays an essential role in determining the selectivity of the PHD fingers. The finding that the histone-binding activity is not conserved in the PHD finger of Set4 suggests different functions for the Set3 and Set4 paralogs. |
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"O",
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... | [
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84... | Levels of the soluble LDL receptor-relative LR11 decrease in overweight individuals with type 2 diabetes upon diet-induced weight loss Cardiovascular disease (CVD) is a major complication in patients with type 2 diabetes (T2D), especially in those with obesity. Plasma soluble low density lipoprotein receptor-relative with 11 ligand-binding repeats (sLR11) plays a role in the development of atherosclerosis and has been linked to the metabolism of triglyceride-rich lipoproteins, adiposity, and vascular complications in T2D. We aimed to determine the effect of diet-induced weight loss on plasma sLR11 levels in overweight and obese individuals with T2D. Plasma sLR11 levels were determined in 64 individuals with T2D and BMI >27 kg/m(2) before and after a 20- week weight loss diet. As a reference, sLR11 levels were also determined in 64 healthy, non-obese controls, matched as a group for age and sex. Median plasma sLR11 levels of the T2D study-group at baseline (15.4 ng/mL (IQR 12.9-19.5)) were higher than in controls (10.2 (IQR: 8.7-12.2) ng/mL; p = 0.001). The diet resulted in a weight loss of 9.7 ± 5.2% (p = 0.001) and improved CVD risk factors. sLR11 levels were reduced to 13.3 ng/mL (IQR 11.0-17.1; p = 0.001). Changes in sLR11 levels positively associated with changes in non-HDL cholesterol (B = 1.54, R(2) = 0.17, p = 0.001) and HbA1c (B = 0.07, R(2) = 0.11, p = 0.007), but not with weight loss (B = 0.04, R(2) = 0.05, p = 0.076). The changes in non-HDL cholesterol and HbA1c together explained 24% of the variance of sLR11 reduction (p = 0.001). Weight loss dieting in overweight and obese individuals with T2D resulted in a reduction in plasma sLR11 levels that was associated with improvements in lipid-profile and glycemic state. |
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... | MiR-495 functions as an adjuvant to radiation therapy by reducing the radiation-induced bystander effect The radiation-induced bystander effect (RIBE) is an important factor in tumor radiation therapy because it may increase the probability of normal cellular injury and the likelihood of secondary cancers after radiotherapy. Here, we identified the role of miR-495 in alleviating RIBEs during radiotherapy. Luciferase reporter assay results confirmed that miR-495 regulated endothelial nitric oxide synthase (eNOS) by targeting the Sp1 3'-untranslated region. Consequently, after radiation, tumor cells expressed less eNOS and Sp1 than controls. In vitro cell irradiation data based on flow-cytometric analysis and enzymed linked immunosorbent assay confirmed that nitric oxide (NO) and its downstream product transforming growth factor β1 (TGF-β1) were critical signaling factors contributing to RIBEs. Fewer normal LO2 liver cells were injured and fewer micronuclei were observed when treated with the medium of the miR-495 overexpressing HepG2 and ZR75-1 tumor cells. Accordingly, treatment with the miR-495 antagomir led to higher NO and TGF-β1 levels and more injured LO2 cells. In vivo experiments indicated that local irradiation of tumors overexpressing miR-495 produced fewer necrotic foci in non-irradiated liver tissue compared with controls. miR-495 was upregulated in clinical cancer tissues compared with adjacent non-cancerous tissues, and radiation significantly reduced the expression level of miR-495 in carcinoma cell lines. In summary, miR-495 may have promise as an adjuvant for tumor radiation therapy to decrease RIBEs involving the Sp1 / eNOS pathway. |
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58,
59
],
[
59,
60
],
[
61,
71
],
[
72,... | Mnk1 (Mitogen-Activated Protein Kinase-Interacting Kinase 1) Deficiency Aggravates Cardiac Remodeling in Mice Identifying the key factor involved in cardiac remodeling is critically important for developing novel strategies to protect against heart failure. Here, the role of Mnk1 (mitogen-activated protein kinase-interacting kinase 1) in cardiac remodeling was clarified. Cardiac remodeling was induced by transverse aortic constriction in Mnk1 - knockout mice and their wild-type control mice. After 4 weeks of transverse aortic constriction, Mnk1 - knockout mice developed exaggerated cardiac hypertrophy, fibrosis, dysfunction, and cardiomyocyte apoptosis and showed increased ERK1/2 (extracellular signal-regulated kinase 1/2) activation along with reduced sprouty2 expression. In line with the in vivo studies, Mnk1 knockdown by Mnk1 siRNA transfection induced exaggerated angiotensin II - induced cardiomyocyte hypertrophy in neonatal rat ventricular myocytes (NRVMs). Moreover, adenovirus -mediated overexpression of Mnk1 in NRVMs protected cardiomyocytes from angiotensin II - induced hypertrophy. In addition, overexpression of sprouty2 rescued NRVMs with Mnk1 knockdown from angiotensin II - induced hypertrophy. In accordance with the in vivo studies, as compared with the control group, Mnk1 knockdown led to hyperphosphorylation of ERK1 / 2 and suppression of the sprouty2 expression in angiotensin II - treated NRVMs; furthermore, Mnk1 overexpression led to hypophosphorylation of ERK1 / 2 in angiotensin II - treated NRVMs. In addition, sprouty2 overexpression suppressed the activation of ERK1 / 2 in angiotensin II - treated NRVMs with Mnk1 knockdown. Impressively, MnK1 - knockout mice with overexpression of sprouty2 exhibited signs of a blunted cardiac hypertrophic response. Mnk1 likely carries out a suppressive function in cardiac hypertrophy via regulating the sprouty2 / ERK1/2 pathway. It implicates Mnk1 in the development of cardiac remodeling. |
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