PMC_ID stringlengths 8 11 | Image_num stringclasses 399 values | Online_file_path stringlengths 20 50 ⌀ | Image_info_Cleaned stringlengths 2 20.6k | Caption_Clean stringlengths 1 10.6k ⌀ | label stringclasses 2 values |
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PMC8952302 | Figure_2 | oa_package/dd/c9/PMC8952302.tar.gz | ['Myocardial and systemic effects of SGLT2i are presented in .', 'The mechanism of action of sodium-glucose co-transporter-2 inhibitors on the cardiovascular system.'] | Figure 2 The mechanism of action of sodium-glucose co-transporter-2 inhibitors on the cardiovascular system. Figure reprinted with permission from ref. [ ]. 2020 Dr. Gary Lopaschuk. Abbreviations: NHEsodium-hydrogen exchange, CAMKIIcalmodulin-dependent protein kinase II, EPOerythropoietin, SNSsympathetic nervous system, Ca calcium. | yes |
PMC4923073 | Figure_1 | oa_package/f3/0f/PMC4923073.tar.gz | ['A 37-year-old female presents with a grade IV frontal lobe AVM.'] | Figure 1 . RMI depicts a right frontal lobe AVM. Anteroposterior angiogram view. Anteroposterior angiogram view after embolization displays a significant reduction of the AVMs size. Anteroposterior and lateral angiogram views conveying total obliteration of the AVM 2years radiosurgery (1700cGy). | yes |
PMC5520279 | Figure_5 | oa_package/08/3a/PMC5520279.tar.gz | ['8%) (figure 5), with seven showing only minor remnants (25%).'] | Figure5 (A, B) A patient with a transitional basilar artery aneurysm 4months after treatment with three telescoped Pipeline embolization devices showing complete reconstruction of the vessel with no further filling of the aneurysm. | yes |
PMC10363690 | Figure_2 | oa_package/3e/ff/PMC10363690.tar.gz | ['Furthermore, Panx1 channels are modulated by post-translational modifications of Panx1 proteins, including phosphorylation, deacetylation and proteolysis ().'] | FIGURE 2 Pannexin1 (Panx1) channels are activated by various triggers. The amount of intracellular calcium ions (Ca ), extracellular adenosine triphosphate (ATP) molecules and potassium (K ) ions, phosphorylation (P), deacetylation and cleavage of Panx1 proteins and mechanical stimulation are underlying mechanisms triggering Panx1 channel activity (+ = induction). | yes |
PMC4643066 | Figure_2 | oa_package/7c/4b/PMC4643066.tar.gz | ['Overexpression of miR-497 enhanced apoptosis and autophagy in cultured neonatal rat cardiomyocytes (NRCs)a.'] | Figure 2 Overexpression of miR-497 enhanced apoptosis and autophagy in cultured neonatal rat cardiomyocytes (NRCs) The levels of miR-497 determined by real time-PCR in response to 24 h transfection of miR-497 mimic or negative control (NC). < 0.01 vs. the NC group, = 5. Experiments were repeated 3 times. Effect of miR-497 mimic on cell apoptosis determined by Hoechst staining in NRCs exposed to normoxia or anoxia/reoxygenation (A/R). Scale bar = 100 m. Effect of miR-497 mimic on cell apoptosis determined by TUNEL in NRCs exposed to normoxia or anoxia/reoxygenation. Scale bar = 100 m. Two-way ANOVA test was performed, F = 69.131 for treatment with miR-497 mimic or NC; F = 138.498 for treatment with normoxia or anoxia/ reoxygenation, = 5. Experiments were repeated 3 times. Effect of miR-497 mimic on formation of autophagosome (indicated by arrow) which was determined by monodansylcadaverine (MDC) staining in NRCs exposed to normoxia or anoxia/reoxygenation (A/R). Scale bar = 75 m. Each experiment was repeated 3 times. Two-way ANOVA test was performed, F = 43.090 for treatment with miR-497 mimic (M) or NC (N); F = 106.406 for treatment with normoxia or anoxia/ reoxygenation (A 3 h/R 2 h), = 9 for each group. Autophagosome under electron microscopy. Scale bar = 2 m. Two-way ANOVA F = 8.944 for treatment with miR-497 mimic or NC, < 0.05, while F = 63.246 for treatment with normoxia or anoxia/ reoxygenation, < 0.001. Autophagosome was counted for 100 optical fields/sample, = 5 for each group. For panel , * < 0.05 vs. the NC group exposed to anoxia 2 h/reoxygenation 3 h (A 2 h/R 3 h), < 0.05 vs. NC group exposed to normoxia. | yes |
PMC9354895 | Figure_4 | oa_package/44/45/PMC9354895.tar.gz | ['Finite element model generation is summarised in .', 'Creation of finite element models.'] | Figure 4 Creation of finite element models. Via anatomical model. A1 is a frozen slice of a horse specimen, A2 a fresh dissection of a rhino thorax . Via computed tomography (CT) imaging in the dog (beagle). B1. CT image of the correct anatomical position (the belt position highlighted with red dashed line) B2. Segmentation of the regions of interest (the heart and lungs red = heart; green = left lung; blue = right lung) B3. Averaging from multiple animals (Thick black line = averaged outer contour) B4. The completed finite element model. | yes |
PMC4169373 | Figure_4 | oa_package/24/04/PMC4169373.tar.gz | ['Apart from the skin rash, old aged patients had cutaneous oedema around the ankles () and puffiness of face with the skin becoming dusky discolouration.', 'g004Acute arthritis of ankle joint and oedematous feet.'] | 10.1371/journal.pntd.0003179.g004 | yes |
PMC5494166 | Figure_6 | oa_package/88/52/PMC5494166.tar.gz | ['More importantly, there is evidence that clusters (C, D and E) are growing on both sides of the ammonoid ().', '3526/fig-6Close-up of the 3D-model showing that sclerobionts are settling on both sides of the shell.'] | 10.7717/peerj.3526/fig-6 | yes |
PMC6077877 | Figure_3 | oa_package/bd/f4/PMC6077877.tar.gz | ['The results are summarized in .', '.', '1177_1179550618792254-fig3"/>Inflammatory cytokines/chemokines concentration in nasal tissueTwenty-six nasal samples were obtained for cytokines/chemokines analyses (14 fungus balls and 12 controls).'] | Figure 3. Western blot analyses of tight junction protein expression obtained in 9 study subjects (A). The relative expressions to house keeping protein are shown in (B). | yes |
PMC6095600 | Figure_7 | oa_package/44/03/PMC6095600.tar.gz | ['In the normal mouse brain, we found some expression of UFO within large neurons and minor reactivity on glia (most likely astrocytes) in the pons and CC ().', 'Within the demyelinating CC, we found clear reactivity on macrophages/microglia; similar reactivity was seen during acute remyelination ().', 'g007Expression of differentially regulated orthologous proteins in the CSF of patients with MS during CPZ-induced de- and remyelination.', 'In the CPZ lesions, we found reactivity in some cells, which by morphology are most likely oligodendrocytes or OPCs; this reactivity was increased during demyelination and acute remyelination in the CC, but not in the pons ().', 'In the CPZ lesions, expression in endothelial cells was low or absent, but there was a variable degree of granular reactivity in macrophages, which was more pronounced during acute remyelination compared to demyelination ().'] | 10.1371/journal.pone.0202530.g007 | yes |
PMC7645685 | Figure_3 | oa_package/44/a9/PMC7645685.tar.gz | ['3a, b, Myc-TDP-43 is mostly localized to the nucleus with some localization in the cytoplasm.', 'Myosin IIB colocalizes to TDP-25 aggregates and facilitates TDP-25-mediated mitophagy.', 'Interestingly, cytoplasmic TDP-43 is partially localized to the GFP-myosin IIB.', '3a, b).', '3c).', '3d f, i, j).', '3g, h).', '3i, j).', '3k).'] | Fig. 3 Myosin IIB colocalizes to TDP-25 aggregates and facilitates TDP-25-mediated mitophagy. Confocal images showing cellular localization of GFP-Myosin IIB together with either Myc-TDP-43 or Myc-TDP-25 in mouse cortical neurons. Scale bar; 10m. The bar graphs show the fluorescence intensity profile across the arrow for green (GFP-Myosin IIB) and red (Myc-TDP-43 or Myc-TDP-25) channels. Coimmunoprecipitation with anti-Myc using HEK293T cell lysates expressing Myc-TDP-43 or Myc-TDP-25. Western blotting was performed using anti-Myc, anti-Myosin IIB antibody. Number sign (#) indicates the nonspecific band. Confocal images showing cellular localization of Tom20, or GFP-Myosin IIB with Myc-TDP-25 in mouse cortical neurons treated with either DMSO or Blebbistatin (10M, 24h). Scale bar; 10m. The graphs show the fluorescence intensity profile across the arrow for green (GFP-Myosin IIB), red (Myc-TDP-25) and blue (Tom20). The bar graph represents % of colocalization of GFP-Myosin IIB with TDP-25 per cell. ** <0.01. Values represent mean+SEM ( 10). Western blotting was performed using the mitochondrial fraction from HEK293T cell lysates expressing Myc-TDP-25 and either Myosin IIB or Myosin VI siRNAs with anti-Myosin IIB, anti-Myosin VI, anti-Myc, anti-Tom20, or anti--actin antibody in the presence or absence of NH Cl. The bar graphs indicate the percentage of normalized protein levels of Myosin IIB, Myosin VI, Myc-TDP-25, or Tom20 with -actin. Cellular images showing mitotracker-positive mitochondria expressing Myc-TDP-25 in the presence or absence of blebbistatin in cultured cortical neurons. Scale bar; 20m. The bar graph indicates the ratio of mitotracker-positive mitochondrial area per cell expressing Myc-TDP-25 in the presence or absence of blebbistatin. * <0.05. Values represent mean+SEM ( 13). The bar graph indicates the percentage of DAPI-positive dead cells with DNA fragmentation in postmitotic neurons expressing Myc-TDP-25 in the presence or absence of blebbistatin. * <0.05. Values represent mean+SEM ( 6). | yes |
PMC10873109 | Figure_2 | oa_package/8b/21/PMC10873109.tar.gz | ['After staining brain sections from the PS19-E4 mice utilized for ISF collection, we observed a strong correlation between the levels of HMGB1 in hippocampal ISF and the coverage area of activated microglia in the hippocampus (C), suggesting a relationship between cellular HMGB1 release and activation of microglia in the hippocampus.', '44,60 To determine the importance of released HMGB1 in triggering acute gliosis in APOE4-related tauopathy, 10-month-old wild-type mice received a unilateral injection of hippocampal ISF collected from 10-month-old PS19-E4 mice that either was enriched with high concentrations of HMGB1 (fractions 19 22 in D) or had undetectable levels of HMGB1 as a control (fractions 3 7 in D).', 'These mice were analyzed 6 days post-injection to assess acute changes in glial response in the hippocampus (E).', 'To determine whether HMGB1 can induce persistent gliosis after its release in the context of APOE4, we injected recombinant HMGB1 (rHMGB1) or saline directly into the hippocampus of young PS19-E4 mice that were 3 months of age (F).', '.'] | Figure 2. APOE4 promotes the cellular release of HMGB1 to induce acute and persistent gliosis in mouse hippocampus (A) HMGB1 protein levels measured by ELISA in the hippocampal interstitial fluid (ISF) of 10-month-old mice. (B) HMGB1 protein levels measured by ELISA in each collected ISF fraction of 10-month-old PS19-E4 mice. Fractions 1 and 2 were excluded from analyses in (A) and (B) since artificial CSF was circulated at a higher flow rate for the first 2 h to prevent clogging of the tubing. (C) Correlation between HMGB1 protein levels in the ISF and the percentage of CD68 coverage area in 10-month-old PS19-E4 mice. (D) HMGB1 protein levels measured by ELISA in each collected ISF fraction of one PS19-E4 mouse used for experiments in (E) and (G)(J). Fractions 37 were designated as HMGB1 absent (HMGB1 ) and fractions 1922 were designated as HMGB1 enriched (HMGB1 ). (E) Experimental design of a study involving the injection of HMGB1-enriched or HMGB1-absent ISF into the hippocampus of 10-month-old wild-type (WT) mice and assessment of acute gliosis 6 days post-injection. (F) Experimental design of a study involving two injections of recombinant HMGB1 (rHMGB1) or saline into the hippocampus of 3-month-old PS19-E4 mice and assessment of gliosis 8 week post-injection. (G) Representative images of microglia stained with anti-Iba1 in the hippocampus of 10-month-old WT mice, part of study in (E) (scale bar, 500 m). (H) Quantification of the ratio of the percentage of Iba1 coverage area between the injected:non-injected hippocampal sides 6 days post-injection. (I) Representative images of astrocytes stained with anti-GFAP in the hippocampus of 10-month-old WT mice, part of study in (E) (scale bar, 500 m). (J) Quantification of the ratio of the percentage of GFAP coverage area between the injected:non-injected hippocampal sides 6 days post-injection. (K) Representative images of microglia stained with anti-Iba1 in the hippocampus of PS19-E4 mice, part of study in (F) (scale bar, 500 m). (L) Quantification of the ratio of the percentage of Iba1 coverage area between the injected:non-injected hippocampal sides 8 week post-injection. (M) Representative images of astrocytes stained with anti-GFAP in the hippocampus of PS19-E4 mice, part of study in (F) (scale bar, 500 m). (N) Quantification of the ratio of the percentage of GFAP coverage area between the injected:non-injected hippocampal sides 8 week post-injection. In (A) and (B), n = 7 mice per genotype. In (C) (PS19-E4, n = 12), Pearsons correlation analysis (two-tailed). In (H) and (J), n = 9 mice for control (HMGB1 ) and experimental (HMGB1 ) groups. In (L) and (N), n = 8 mice for rHMGB1 and saline control groups. All data are represented as the mean SEM, unpaired two-tailed t test. | yes |
PMC3118011 | Figure_3 | oa_package/3b/2e/PMC3118011.tar.gz | ['The retina remained fully attached [].', 'The fundus photography of the right eye at the three-month follow-up showing the silicon oil reflexes and fully attached retina at the posterior poleDiscussionScleral pathology is one of two major risk factors for globe rupture during retinal detachment surgery; the second is reoperation after a failed retinal detachment surgery.'] | Figure 2a Two weeks after the scleral patch graft procedure the scleral graft edge with sutures was exposed during the pars plana approach for vitrectomy (superior temporal quadrant of the globe). The scleral graft was in place with signs of epithelization | yes |
PMC7525270 | Figure_3 | oa_package/7a/3f/PMC7525270.tar.gz | ['In the obstetric field, transarterial uterine arteries embolization is a recognized procedure for the management of postpartum hemorrhage that is a major cause of maternal morbidity and mortality; new endovascular techniques are proposed also as preventive strategies before partum in patients at high risk, especially those with abnormal invasive placenta.'] | Figure 3 A 31-year-old lady with pelvic congestion syndrome causing pelvic pain for 1 year, treated by endovascular embolization. Fluoroscopy shows catheterism of an insufficient and ectasic left ovarian vein with parauterine reflux (A); sclerosant injection and coils embolization of the left ovarian vein (B). Controlateral digital subtraction angiography (DSA) demonstrating insufficiency and massive dilation of the right ovarian vein with marked parauterine reflux (C) that was similarly occluded with sclerosant coils (D). | yes |
PMC8394175 | Figure_3 | oa_package/0f/56/PMC8394175.tar.gz | ['After analyzing all these parameters for each histopathological aspect, a correlation was found between mixed echogenicity of endometrial fluid and an aspect of endometrial line (a f).', '(a) Correlation between mixed echogenicity of endometrial fluid and an aspect of endometrial line; (b) between ground glass description of endometrial fluid aspects and circular flow; (c) non-linear endometrial midline and multiple vessels with multifocal origin vascular features; (d) echogenic mixed and multiple vessels with multifocal origin; (e) not defined aspects of endometrial midline and multiple vessels with multifocal origin; (f) echogenic mixed endometrial fluid with circular flow.'] | Figure 3 ( ) Correlation between mixed echogenicity of endometrial fluid and an aspect of endometrial line; ( ) between ground glass description of endometrial fluid aspects and circular flow; ( ) non-linear endometrial midline and multiple vessels with multifocal origin vascular features; ( ) echogenic mixed and multiple vessels with multifocal origin; ( ) not defined aspects of endometrial midline and multiple vessels with multifocal origin; ( ) echogenic mixed endometrial fluid with circular flow. Legend: CIConfidence interval. | yes |
PMC6180189 | Figure_5 | oa_package/58/77/PMC6180189.tar.gz | ['BSSM activates AKT/GSK3 pathway, promotes tau hyperphosphorylation and PHF accumulation and increases the expression of active asparagine endopeptidase (AEP) and tau cleavage.'] | Figure 5 BSSM activates AKT/GSK3 pathway, promotes tau hyperphosphorylation and PHF accumulation and increases the expression of active asparagine endopeptidase (AEP) and tau cleavage. Western blotting showed higher expressions of p-AKT and the downstream p-GSK in hippocampus in BSSM treated group. Phosphorylation of tau at S396 was higher in BSSM group than in sham and USSM group. PHF accumulation also showed significant differences between sham and the two shear stress modifier groups. Expression of active AEP and tau N368 truncation were higher in BSSM group. Immunofluorescent staining further reconfirmed the finding that BSSM group had more tau N368 fragments in hippocampus than the other two groups. L, left hippocampus; R, right hippocampus. * < 0.05, ** < 0.01. Data were presented as Mean SD. = 4 in each group. Scale bar, 100 m. | yes |
PMC6066957 | Figure_5 | oa_package/37/f9/PMC6066957.tar.gz | [] | Figure4 Hyperphosphorylation of Tau and Apoptosis Are Not Controlled by the Levels of Gene Expression (A) Hydrogen peroxide-induced cell death measured by fluorescence-activated cell sorting of TUNEL-labeled cells in DS neuronal cultures at days 45. (B and C) (B) Day 90 DS cultures and (C) day 90 Gen22::TRE-dCas9-VP64 hESC-derived neurons (gRNAs as labeled). (D) Western blots of P-T212, P-S396, and total Tau in day 90 DS, APP copy-number-corrected, and isogenic euploid neurons and their quantification relative to TUBB3. (E) Western blotting of day 90 Gen22::TRE-dCas9-VP64 hESC-derived neurons with T212 Tau antibody and quantification relative to totalTau. (F) Overlaid images of MC1 (paired helical filament-containing) NFT-like aggregates (highlighted by arrowheads) in Hsa21-trisomic, APP copy-number-normalized, and euploid day 120 cortical neurons. (G) Quantification of the frequency of MC1 NFT-containing neurons per field of view in D120 cortical neuronal cultures. (H) Detection of hyperphosphorylated tau accumulation using AT270 antibody in day 120 DS, APP copy-number-corrected, and isogenic euploid neurons. (I) Levels of total Tau protein in day 90 Genea22::TRE-dCas9-VP64 hESC-derived neurons overexpressing APP, relative to TUBB3. p< 0.05, p< 0.01, p< 0.001, #non-significant. Values shown are means SEM of three experiments. | yes |
PMC10713242 | Figure_9 | oa_package/6b/47/PMC10713242.tar.gz | ['As mentioned above, ~70% of PM-LBCLs are positive for p63 (but not p40) and exclusion or confirmation of an hematolymphoid origin should be done with CD45, CD20/PAX5, and pan-CK ().', 'PM-LBCL is positive for p63 in ~70% of cases ( 400).'] | Figure 9 PM-LBCL is positive for p63 in ~70% of cases (400). Inset: the PAX5 immunostain confirms a B-cell lineage (400). Pathologists should be aware to not misinterpret a p63+ epithelioid tumor from the anterior mediastinum as squamous/thymic carcinoma without first performing pan-cytokeratin. PM-LBCL, primary mediastinal (thymic) large B-cell lymphoma. | yes |
PMC2141652 | Figure_9 | oa_package/ae/93/PMC2141652.tar.gz | [' 9).', '', 'PP proximal phalanx, MP middle phalanx'] | Fig.9 Small effusion on the flexor aspect of the proximal interphalangeal joint. Fluid thickness is measured at 1.6mm and extends out of the proximal recess ( ). Compare with Fig. . proximal phalanx, middle phalanx | yes |
PMC3297633 | Figure_3 | oa_package/b9/46/PMC3297633.tar.gz | ['ulcerans induced a significant peak in the total number of cells at day 21 post-infection (A), including CD4 and CD8 cells (B and C), which later declined with the progression of the infectious process, as previously described <xref rid="pone.', 'g003Vaccination with BCG induces an early CD4 T cell response in the DLN of M.'] | 10.1371/journal.pone.0033406.g003 | yes |
PMC6141703 | Figure_5 | oa_package/f8/6c/PMC6141703.tar.gz | ['In the WST-8 cell proliferation assay, the percentage of proliferative cells was significantly increased by G1 treatment (, A and B).', 'In BrdU labeling analysis, the ratio of BrdU-positive cells was significantly increased by G1 treatment (, C and D).', 'GPR30-specific agonist increases proliferation of cervical adenocarcinoma cells.', 'Positive correlation of overexpression of GPR30 and claudin-1 in surgical specimens of human cervical adenocarcinoma.', 'At least, we observed that a GPR30-specific agonist, G1, enhances proliferation of cervical adenocarcinoma cells ().'] | Figure 5 GPR30-specific agonist increases proliferation of cervical adenocarcinoma cells. (A-B) WST-8 assay. Cell proliferation was increased by G1 treatment in CAC-1 (A) and HCA1 (B) cells. (C-D) Bromodeoxyuridine (BrdU) incorporation (red) was increased by G1 treatment (10 nM, 24 hours) in CAC-1 (C) and HCA1 (D) cells. Bar graphs show the percentage of BrdU-positive cells. * < .05. | yes |
PMC6766091 | Figure_3 | oa_package/06/fb/PMC6766091.tar.gz | ['The pathological review of the resected mass showed puzzle-shaped pieces of hepatic parenchyma embedded in hyalinized matrix (hematoxylin and eosin stain with 200x magnification), consistent with a mesenchymal hamartoma ().', '002"/>Puzzle-shaped pieces of hepatic parenchyma embedded in hyalinized matrix (hematoxylin and eosin stain with 200x magnification).'] | Figure 3 Puzzle-shaped pieces of hepatic parenchyma embedded in hyalinized matrix (hematoxylin and eosin stain with 200x magnification). | yes |
PMC5748183 | Figure_3 | oa_package/62/70/PMC5748183.tar.gz | [] | Fig. 3. FKBP12 modulates calcineurin (CN) activity by altering its phospho-dependent proteome. ( ) Heat map representing 527 hypophosphorylated phosphosites with abundances based on an MS shotgun approach. Cutoff was a |log2 FC| > 2 and value < 0.05 between control and -synexpressing yeast cells across the different conditions. All of the Excel sheets associated with the data are available as tables in . ( ) Diagram exemplifying how the CN- and FKBP12-dependent phosphosites were chosen. ( ) Diagram of the proteins that contain all of the reverted CN/FKBP12-dependent phosphosites. Functions are annotated according to the SGD. ( ) -SynGFP localization in yeast cells in the presence ( , ) and absence ( , ) of protective dose of Tacrolimus (30 g/mL). ( , ) Western blot for CPY in -synexpressing cells in the presence and absence of a protective dose of Tacrolimus (30 g/mL). Higher-molecular weight band represents the glycosylated form of CPY, which is typically found in the ER. The lower-molecular weight band (post-ER) is deglycosylated CPY, which has moved beyond the ER through the secretory pathway. Phosphoglycerate kinase (PGK) is used as a loading control. ( , ) Quantitation of the ER and post-ER CPY bands from the Western blot; bands were quantitated using the Odyssey software. * < 0.05 (one-way ANOVA, Dunnett's multiple comparison test). | yes |
PMC4065072 | Figure_2 | oa_package/0a/7e/PMC4065072.tar.gz | ['Peak viral RNA loads were found in the tissues of KFDV-infected mice earlier than AHFV-infected C57BL/6J miceKFDV-infected mice had higher viremia 1 day post-infection (dpi), but blood from AHFV-infected mice had vRNA present through 7 dpi (A).', 'The highest vRNA titers in the spleens were found 1 dpi, suggesting the spleen is an early site for virus amplification for both viruses (B).', 'KFDV-infected mice had high vRNA loads in the gastrointestinal tract (C) and brain (D) beginning 4 dpi.', 'g002KFDV-infected mice have higher viral RNA loads than AHFV-infected mice early in infection.'] | 10.1371/journal.pone.0100301.g002 | yes |
PMC10393261 | Figure_7 | oa_package/36/eb/PMC10393261.tar.gz | ['Cell population markersChangeT cells, CD3+Down*\n\n3A\n\nB cells, CD19+Up*\n\n3A\n\nT cells, TCRgd+Up*\n\n3F\n\nMonocytes CD16+ CD14+Up*\n\n3B\n\nNeutrophils, CD16+ CD66b+Up*\n\n3B\n\nNK cells, CD56+Down*\n\n3E\n\nNK CD56hi CD16loUp*\n\n3E\n\nNK, CD226- NKp44+Down*\n\nSup F\n\nNK, CD226- NKp44-Up*\n\nSup F\n\nNK, CD158el- CD158el/e2-Down**\n\nSup C\n\nNK, CD158el+ CD160+Up**\n\nSup D\n\nNK, CD158el+ CD160-Up*\n\nSup D\n\nNK, CD158el+ NK.'] | Figure7 Cytokine production by expanded peripheral blood T cells. T cells were expanded for 7 days by activation with anti-CD3+CD28 and cultured with IL-2. At day 7, cells were washed and restimulated for 6h with anti-CD3+CD28 or with PMA+ionomycin. CD4 and CD8 T cells expressing IL-2, IFN- and TNF were monitored by intracellular cytokine staining and flow cytometry. In parallel, granzyme B expression was monitored. Plots show the percentage of CD4 and CD8 T cells expressing IL-2 , IFN- , TNF and granzyme-B (GzmB; ). Pairs of sex and age matched FAP and healthy subjects are shown linked by a line. Each dot represents a subject. Round black dots correspond to healthy subject and red, square dots correspond to FAP subjects. n = number of pairs. Significance was determined by the Wilcoxon rank test. The values are represented as follows: ** < 0.01, * < 0.05. | yes |
PMC3430619 | Figure_2 | oa_package/5b/1f/PMC3430619.tar.gz | ['The first was a qualitative assessment of localized metritis in the portion of the uterine tissue attached to the placenta and the uterine tissue surrounding the implantation site ().', 'Most C57BL/6 dams exhibited metritis that was characterized as scant neutrophilic infiltrates in the endometrium and myometrium (B).', 'g002Representative images of metritis.'] | 10.1371/journal.pone.0044047.g002 | yes |
PMC11426176 | Figure_1 | oa_package/f9/65/PMC11426176.tar.gz | ['4 cm (A, 1B).', '\nObstet Gynecol\n1997\n89\n5 Pt 2\n853\n54\n9166349\n.'] | Figure 1. B-ultrasound of case 1. The results displayed 2 uneven low echoes in the pelvic cavity, with sizes of approximately 5.25.13.7 cm ( ) and 2.52.02.4 cm ( ), respectively (the red arrow indicates the location of the low echo). | yes |
PMC6248806 | Figure_10 | oa_package/f6/90/PMC6248806.tar.gz | [] | Figure 10 Selective angiography performed by steering the microcatheter (red arrows) into the right uterine artery demonstrated supply of a large fibroid (red circle). | yes |
PMC7396049 | Figure_1 | oa_package/6d/72/PMC7396049.tar.gz | ['The system consisted of a total of 59,914 atoms ().', '0-3384602158217056733Snapshot of the last frame of the molecular modeling system for DerfAQP1.'] | Figure 1 Snapshot of the last frame of the molecular modeling system for DerfAQP1. Builder program provided within the VMD software. Chloride is shown in the indigo blue ball model, sodium is shown in yellow, and proteins are represented by cartoons. Residue type is represented by color: hydrophobic in white, polar hydrophilic in green, negatively charged in red, and positively charged in blue. The water box drawn in MSMS provides VMD fast surface calculation and display with a size of 80 80 100 and a total of 59,914 atoms. | yes |
PMC11522865 | Figure_3 | oa_package/69/0b/PMC11522865.tar.gz | ['Exercise-induced adaptions to cardiac structure and function evaluated by echocardiography at rest.'] | Figure 2 Extracts from echocardiographic evaluation of diastolic function in an endurance athlete. ( ) Normal GLS. ( ) Dilated LV, normal LV EF. ( ) Normal peak E-wave, elevated E/A ratio. ( ) Dilated LA. ( ) Normal septal e. ( ) Normal TR Vmax. E/A ratio, peak early-to-late diastolic mitral inflow velocity ratio; E-wave, peak early-diastolic mitral inflow velocity; e, peak early-diastolic mitral annular velocity; GLS, global longitudinal strain; LAESVi, indexed left atrial end-systolic volume; LA, left atrium; LV, left ventricle; TR V , tricuspid regurgitant peak velocity. | yes |
PMC8672862 | Figure_2 | oa_package/3c/09/PMC8672862.tar.gz | ['We performed 3 additional cases using this technique ().', '.', 'Ethical ConsiderationsThis work was approved by the Clinics Hospital, University of S o Paulo School of Medicine Ethical Committee (protocol number 3951.'] | Figure 2. , Macroscopic view of pulmonary fragment sampled from a late coronavirus disease 2019 case obtained by a small thoracotomy guided by ultrasound image. Red arrows indicate thromboembolic event. , Microscopic view showing areas of overinflation and disrupted alveolar septa (corresponding to white arrow and red dotted line rectangle marked in ). , Foci of subpleural condensation with fibrotic bundle deposition and reactive epithelium (corresponding to black arrows and solid red line rectangle marked in ). , Macroscopic view of a pulmonary thrombus. , Tricuspid valve leaflet of the same patient showing a valvular thrombus. , Skin and chest wall incision. . Instruments used to insert optics and forceps for dissections. , Segment of the intestines obtained with the dissection technique. Scale bar for microscopic images = 500 m. | yes |
PMC11218534 | Figure_2 | oa_package/24/11/PMC11218534.tar.gz | ['The left plantar heel with dermoscopic imagingA slightly deep, darkened hue can be appreciated under the keratin.'] | Figure 2 The left plantar heel with dermoscopic imaging A slightly deep, darkened hue can be appreciated under the keratin. | yes |
PMC10561387 | Figure_1 | oa_package/8d/13/PMC10561387.tar.gz | [] | Figure1 Scurfy mice produce ANA in the absence of Treg. Representative images by IFA on HEp-20-10 cells and primate liver tissue with WT (upper panel) and scurfy (lower panel) serum. Scale bars, 50 m. Semiquantitative IFA analysis with ANA titers in sera of WT and scurfy mice ****p<0.0001 (Mann-Whitney U test). Analysis of ANA patterns in WT and scurfy sera by using designated codes from AC-0 (negative) to AC-29, according to ICAP nomenclature (scurfy n=20, WT n=20). Representative images by IFA on HEp-20-10 cells with hybridoma supernatants directly obtained scurfy mice. Cytoplasmic fibrillar linear pattern (AC-15, middle panel), cytoplasmic discrete dots/GW-body like pattern (AC-18, right panel), and negative control (left panel) are shown. Scale bars, 50 m (larger images) and 20 m (close-up views). | yes |
PMC3851064 | Figure_1 | oa_package/90/de/PMC3851064.tar.gz | ['(a) Rectocele at ECCD defined as an out-pouching of the anterior rectal wall occurring during evacuation or straining, correctly identified also at MR-Defecography(b).'] | Figure 1 . | yes |
PMC8628155 | Figure_3 | oa_package/14/f0/PMC8628155.tar.gz | ['The majority of PEF do not show posterior acoustic artifacts, however PEF rarely show posterior acoustic shadowing or comet-tail artifacts in PTC ().', 'Although echogenic foci with comet-tail artifacts at the margin of the cystic component are commonly found in benign nodules [6973], they are not specific for benign nodules () [73].', 'pdf" id="d64e10519" position="anchor"/>Supplementary US features of indeterminate lymph nodes.', 'K-TIRADS = Korean Thyroid Imaging Reporting and Data SystemPapillary carcinomas with echogenic foci and posterior acoustic artifacts.'] | Fig. 3 Papillary carcinomas with echogenic foci and posterior acoustic artifacts. Solid and mildly hypoechoic nodule with punctate echogenic foci (K-TIRADS 5, high suspicion). Punctate echogenic foci with posterior acoustic shadowing are observed in the lower part of the nodule (arrows). Solid and markedly hypoechoic nodule with punctate echogenic foci accompanying the comet-tail artifact (arrow) (K-TIRADS 5, high suspicion). Predominantly solid and markedly hypoechoic nodule with punctate echogenic foci accompanying the comet-tail artifact (thick arrow) (K-TIRADS 4, intermediate suspicion). US image shows irregular nodule margins (thin arrows). Predominantly cystic and mildly hypoechoic nodule with echogenic foci accompanying the comet-tail artifact at the margin of the cystic component (thick arrow) (K-TIRADS 4, intermediate suspicion). US image shows punctate and large echogenic foci within the solid component of the nodule (thin arrows). K-TIRADS = Korean Thyroid Imaging Reporting and Data System, US = ultrasonography | yes |
PMC2596112 | Figure_1 | oa_package/cd/62/PMC2596112.tar.gz | ['Endoscopy image of a pedunculated polyp filling ileal lumen.'] | Figure 1 Endoscopy image of a pedunculated polyp filling ileal lumen. | yes |
PMC11602531 | Figure_2 | oa_package/7c/9d/PMC11602531.tar.gz | ['Small mediastinal hematoma, 24 mm in depth from the posterior surface of the sternumLaboratory tests were all within normal ranges.'] | Figure 2 Small mediastinal hematoma, 24 mm in depth from the posterior surface of the sternum | yes |
PMC4000210 | Figure_3 | oa_package/ba/d1/PMC4000210.tar.gz | ['0095807-Riedmuller1" ref-type="bibr">[31] (A).', 'Nevertheless, the quantification of plaque components by histo-pathological analysis of the treated carotids with hematoxylin-eosin, oil-red O staining and with CD68 antibody (specific of the macrophages), further confirmed this observation (B to D).', 'In addition, the cholesterol content of the liver of the mice was significantly decreased after silencing P2Y13R expression (E).', 'The concomitant dosing with CT1007900 (at 100 g/kg/day) for 2 weeks along with high-cholesterol diet showed a decrease in the cholesterol content (60% decrease) of the ligatured carotids in mock adenovirus-treated mice (F).', 'By contrast, the effect of P2Y13R agonist on cholesterol content in carotids was completely abolished in mice treated with shRNA targeted against the P2Y13R (P2Y13R knocked-down), further supporting the specificity of the P2Y13R in this model (F).', 'g003Effect of CT1007900 on atherosclerotic plaque progression in carotids of apoE / mice.'] | 10.1371/journal.pone.0095807.g003 | yes |
PMC6233188 | Figure_2 | oa_package/2b/78/PMC6233188.tar.gz | [' 2a).', 'Characterization of normal tau fragmentation.', 'To further characterize the individual N-terminal fragments, especially N-LMW2, we performed isoform-specific immunoblotting on immunoprecipitated tau fragments.', ' 2b, Ladder lane).', ' 2b).', ' 2c).', ' 2d).'] | Figure 2 Characterization of normal tau fragmentation. ( ) Immunoprecipitation of N-terminal-intact tau followed by immunoblotting with region-specific tau antibodies in human fusiform gyrus cortex lysate (AD Braak III/IV). Ladder, full length recombinant tau (6 isoforms); input, 1/10 of lysate for IP; Mock, mock IP with normal IgG; N-ter, tau IP with in-house N-terminal specific antibody N-ter; sup, IP supernatant; IP, eluent of IP from 100 g brain lysate. ( ) Isoform-specific immunoblotting of N-terminal-intact tau in human control frontal cortex lysate. Lanes: input, 1/10 of lysate for IP; Mock, mock IP with normal IgG, N-ter, tau IP with N-ter antibody, Ladder, full length recombinant tau (6 isoforms). The ladder band in 4R is on the same gel but from a longer exposure due to low signal. ( ) Table summary of N-terminal fragment isoform identification from ( ) Bands i-vi are detected with Tau13 immunoblotting, and bands i and ii are new fragments detected with 2N antibodies (in house). ( ) Immunoprecipitation followed by immunoblotting of tau protein with C-terminal domain from human control frontal cortical lysate. Input, 1/10 of brain lysate for IP; Mock, mock IP with normal mouse IgG; Mid-1, tau IP with in house mid-domain specific antibody Mid-1; C-ter-1 and C-ter-2, tau IP with in-house C-terminal-specific antibodies C-ter-1 and C-ter-2; sup, IP supernatant; IP; eluent of IP from 100 g brain lysate. Black arrowheads, 14 kDa C-LMW4 bands. Full length figures of all cropped blots are shown in Supplementary Fig. . | yes |
PMC11458899 | Figure_2 | oa_package/6d/96/PMC11458899.tar.gz | [' 2).', '\nInflammatory cells in the myocardium of cardiac amyloidosis.', '\nIn the next step we examined the correlation between clinical parameters and amyloid load in AL amyloid only, ATTR amyloid only, all amyloid cases, the diameter of cardiomyocytes and the density of immune cells.'] | Fig. 2 Inflammatory cells in the myocardium of cardiac amyloidosis. Exemplary immunostaining with antibodies directed against CD3 (T lymphocytes) ( ), myeloperoxidase (neutrophiles) ( ), CD68 (macrophages) ( ) on an area of 0.12 mm . Arrows show positive corresponding immune cells (1 T lymphocyte, 4 neutrophils and 3 macrophages). Original magnifications 400-fold, hematoxylin counterstain. | yes |
PMC5325334 | Figure_1 | oa_package/d9/7b/PMC5325334.tar.gz | ['Up-regulation of PVT1 in liver fibrosis and effects of PVT1 on HSC activation in vitroA.'] | Figure 1 Up-regulation of PVT1 in liver fibrosis and effects of PVT1 on HSC activation Schematic diagram of variants of the PVT1 transcript. Color boxes indicated the exons of variants of the PVT1 transcript. Black boxes indicated the siRNAs for PVT1 transcript variant 1. Black arrows indicated the PCR primers in the variants. Notably, the sequences of the exon 1 of PVT1 transcript variant 2 were different from those in PVT1 transcript variant 1. Moreover, the sequences of the exon 1 and exon 5 of PVT1 transcript variant 3 were different from those in PVT1 transcript variant 1 and 2. PVT1 transcript variant 1, PVT1 transcript variant 2 and PVT1 transcript variant 3 expressions were detected by qRT-PCR in primary HSCs. PVT1 was analyzed by qRT-PCR in CCl mice. PVT1 was measured by qRT-PCR in primary HSCs transfected with siPVT1. Cell proliferation was determined by the EdU assay. The mRNA and protein expression levels of -SMA and type I collagen were analyzed in primary HSCs transfected with siPVT1. GAPDH was used as internal control. * < 0.05 compared to the control. Each value is the mean SD of three experiments. | yes |
PMC9673307 | Figure_6 | oa_package/26/d2/PMC9673307.tar.gz | [' 6A C), so did the curves of OCR (', ' 6D G).', ' 6H).', ' 6I), the absorption of glucose was correlated to the proliferative activity of cells.', ' 6J, WZ35 enhanced the ratio of NAD+ to NADH, signifying the blockade of oxidative phosphorylation.', ' 6K.', 'WZ35 caused a significant disturbance in the cellular metabolic state.', 'K Proposed working model showed distinct metabolic changes after drug actionYAP combined GLUT1 may serve as a valuable prognostic and/or diagnostic biomarker in liver cancerWe further explored clinical application of YAP and GLUT1 in above tissue chip with 53 liver cancer samples.', ' 6I).'] | Fig. 6 WZ35 caused a significant disturbance in the cellular metabolic state. and ECAR and OCR was measured with Seahorse XF96 Flux analyzer in HCCLM3 cells. and Glycolytic capacity and maximal glycolytic capacity reserve were measured in non-glucose medium after the addition of glucose (10mM), oligomycin (1M) and 2-DG (100mM). Basal respiration, maximal respiration and ATP production were measured after the injection of oligomycin (1M), FCCP (0.5M) and AA/Rot (2M). The glucose concentration of culture medium was detected by hexokinase method. The absorption of glucose was measured in combination with CCK-8 assay in either non-glucose-treated or low glucose-treated or high glucose-treated or high glucose plus 2-DG-treated HCCLM3 cells with or without treatment of WZ35. The contents of metabolic products in HCCLM3 cells treated with or without WZ35 (10g/mL). All these results have been presented as the meanstandard error from independent experiments in triplicate. * <0.05, ** <0.01, *** <0.001, **** <0.0001, students test. Proposed working model showed distinct metabolic changes after drug action | yes |
PMC9631745 | Figure_2 | oa_package/88/53/PMC9631745.tar.gz | ['org/1999/xlink" xlink:href="ao2c03185_0002" id="gr1" position="float"/>The selected docked pose of HupA\nand its corresponding\n2D and 3D\ninteraction plots are depicted in .', 'A shows that HupA\nbound tightly through three conventional hydrogen bonds with Thr392,\nGlu394, and Ser688, along with several other interactions such as\nvan der Waals contacts.', 'It was apparent from the figure\nthat HupA was near Tyr411 and shared a hydrophobic interaction (A).', 'The charged potential\nof the Tf binding pocket occupied by HupA is shown in B.', 'Selected docked pose of HupA and its corresponding\n(A) 2D and (B)\n3D interaction plots.', 'The intermolecular hydrogen bond analysis is highly consistent\nwith the static result from the molecular docking of Tf-HupA, where\nthree hydrogen bonds were involved in complex formation ().'] | Figure 2 Selected docked pose of HupA and its corresponding(A) 2D and (B)3D interaction plots. | yes |
PMC6702254 | Figure_3 | oa_package/ea/27/PMC6702254.tar.gz | ['3 and 4), neuronal migration anomalies (', 'Post-mortem ultrasound images of the brain, in coronal section (top row), with matched T2-weighted post-mortem MRI images (bottom row) performed on the same day, in a foetus at 21 weeks gestation, 9 days after death.', 'From the post-mortem ultrasound, the ventriculomegaly was well depicted before the MRI was performed, and a corpus callosum was in fact present (white arrows)Post-mortem ultrasound images of the brain, in coronal section (top row), with matched T2-weighted post-mortem MRI images (bottom row) in a foetus at 25 weeks gestation.'] | Fig. 3 Post-mortem ultrasound images of the brain, in coronal section (top row), with matched T2-weighted post-mortem MRI images (bottom row) performed on the same day, in a foetus at 21weeks gestation, 9days after death. These have been obtained through the frontal lobe ( , ), at the level of the Foramen of Monro ( , ) and through the posterior horns of the lateral ventricles ( , ). The pregnancy was terminated for suspected foetal ventriculomegaly and an absent corpus callosum. From the post-mortem ultrasound, the ventriculomegaly was well depicted before the MRI was performed, and a corpus callosum was in fact present (white arrows) | yes |
PMC5706103 | Figure_4 | oa_package/8b/a8/PMC5706103.tar.gz | ['UICLM regulates the stemness of CRC cells.'] | Figure 4 UICLM regulates the stemness of CRC cells. ( ) Knockdown of UICLM significantly reduced the SP cell proportion in SW620 (reduce from 9.52% to 2.91%) and DLD-1 (reduced from 5.34% to 2.44%) cells. ( ) Knockdown of UICLM significantly reduced sphere formation in SW620 and DLD-1 cells (* < 0.05) (Scale bar: 100 m). ( ) Knockdown of UICLM markedly reduced the expression of stemness-associated genes (Nanog, Oct-4, SOX2, Notch1), multiple drug-resistant transporter genes (ABCG2) and surface antigens associated with cancer stem cells (CD24, CD44, CD133, CD155 and CD166) in both SW620 and DLD-1 cells (* < 0.05). ( ) - ) 83.3% of the mice developed tumors when injected with 2.0 10 SW620 sh-NC cells, whereas the tumor incidence was reduced to 33.3% when mice were injected with SW620 sh-UICLM cells (Group #1). The tumor incidence was 58.3% in the control group when the mice were injected with 1.0 10 cells, and the tumor incidence was reduced to 16.6% in the sh-UICLM group (Group #2). The tumor incidence was 33.3% in the control group when the mice were injected with 1.0 10 cells, and the tumor incidence was reduced to 8.3% in the sh-UICLM group (Group #3). ) The tumor volume and tumor weight were significantly decreased in the sh-NC group compared with that in the sh-UICLM group (* < 0.05) (Scale bar: 1.5 cm). | yes |
PMC8084778 | Figure_2 | oa_package/9b/ee/PMC8084778.tar.gz | [' 2a) with right heart dilatation and marked caecal thickening, suggestive of malignancy, with localised bowel perforation (', ' 2b).', 'a CTPA showing bilateral PE, b CT abdomen showing marked caecal thickening (red arrow) and adjacent air pocket secondary to bowel perforation (blue arrow), c and d degree of TR pre, and post U-ACDBedside echocardiography confirmed severe right heart dilatation and impairment, with pulmonary hypertension (RV:LV 1.', ' 2c).', ' 2d).'] | Fig. 2 CTPA showing bilateral PE, CT abdomen showing marked caecal thickening (red arrow) and adjacent air pocket secondary to bowel perforation (blue arrow), and degree of TR pre, and post U-ACD | yes |
PMC6248012 | Figure_1 | oa_package/7b/14/PMC6248012.tar.gz | ['The mean TPA, used as a marker of low muscle mass, was determined by a single radiologist measuring the cross-sectional area of the psoas muscles on pre-transplant MRI or CT scans at the level of the L4 vertebral body; the areas of the right and left psoas muscles were averaged to determine a mean TPA ().', 'post-MELD erasAliment Pharmacol Ther20052121697715679767CT abdomen/pelvis at L4 vertebral level demonstrating patient total psoas area.'] | Figure 1 CT abdomen/pelvis at L4 vertebral level demonstrating patient total psoas area. The mean cross-sectional area of the left and right psoas muscle at the level of the fourth lumbar vertebra (L4) was determined. This was accomplished by first identifying the individual vertebral levels on a CT scan of the abdomen and pelvis. We then selected the individual imaging slice at the mid-portion of the L4 vertebra and outlined the borders of the left and right psoas muscle. The cross-sectional area (in mm ) of the enclosed regions was used to calculate the mean total psoas muscle area (TPA). | yes |
PMC9705072 | Figure_2 | oa_package/de/a1/PMC9705072.tar.gz | ['A) TEE of the bioprosthetic MV with flail anterior prosthetic leaflet (yellow arrow).'] | Figure 2 A) TEE of the bioprosthetic MV with flail anterior prosthetic leaflet (yellow arrow). B) Severe eccentric mitral regurgitation (green arrow). TEE:Transesophageal echocardiogram; MV: Mitral valve | yes |
PMC5586456 | Figure_2 | oa_package/6a/50/PMC5586456.tar.gz | ['\nCLR01 inhibits R120G induced protein aggregation in a dose dependent manner.'] | Figure 2 01 inhibits R120Ginduced protein aggregation in a dosedependent manner. Neonatal rat ventricular cardiomyocytes were infected with Ad Cry and treated with different doses of 01 or 03. A and B, s were fixed and immunostained with troponin I (TnI; red) and 4',6diamidino2phenylindole ( , nuclear staining; blue). C and D, Aggregates (green) in the neonatal rat ventricular cardiomyocytes were quantitated using elements (Nikon) software. E, Doseresponse curve for 01 inhibition of R120Ginduced protein aggregation. At least 100 cells were quantitated in each group for each experiment, and each group was replicated n=6. The value is indicated. R120G indicates Ad Cry . * <0.05, ** <0.01. | yes |
PMC8349650 | Figure_6 | oa_package/36/8d/PMC8349650.tar.gz | [] | FIGURE 6 The effect of repopulated microglial cells in the substantia nigra of mice at 7 days after MPTP administration and the results of the Pole test. (A) Schematic schedule of the MPTPdriven PD mice models with repopulated microglia. (B, C) Immunohistochemical staining (B) and stereological count showing TH cells (C) in the SNpc. NS group: CDNSCD; MPTP group: CDMPTPCD; repopulationMPTP group: PLX3397/21dCD/7dMPTPCD. n = 8. (D, F) Immunofluorescence staining of Iba1 (green) and TH (red) in the SNpc; Scale bar: 100 m (D) and quantification of Iba1 microglial cells in the SNpc (F). n = 34. (E, G) Immunofluorescence staining of GFAP (green) and TH (red) in the SNpc; Scale bar: 100 m (E) and quantification of GFAP astrocytic cells in the SNpc (G). n= 34. (H, I) The results of the Pole test at 3 days (H) and 7 days (I) after MPTP administration; n = 910. NS: normal saline; CD: control diet; PLX3397: PLX3397formulated diet. Oneway ANOVA followed by HolmSidaks multiple comparisons test was used for statistical analysis. < .05, < .01, < .0001 | yes |
PMC5134294 | Figure_3 | oa_package/5c/dd/PMC5134294.tar.gz | [' 3) [7, 8].', ' 3a).', ' 3b, c).', 'Surgical specimen from resection.', 'Image (d) demonstrates closing time at the end of the operation once all margins were negative\nProtocolThe research protocol was submitted and approved by the research ethics committee of our institution before chart review was initiated.', ' 3 and 4).'] | Fig. 3 Surgical specimen from resection. Intraoperative Mohs margins. Image ( ) demonstrates the surgical specimen about to be resected with proper orientation in both patient and the specimen. Images ( and ) demonstrate the resected specimen with corresponding sutures. Image ( ) demonstrates closing time at the end of the operation once all margins were negative | yes |
PMC11273202 | Figure_3 | oa_package/1d/81/PMC11273202.tar.gz | [] | Figure 3 An example of the tractography of the inferior longitudinal fasciculus | yes |
PMC3961819 | Figure_1 | oa_package/a4/7d/PMC3961819.tar.gz | ['12-15 A recent amyloid imaging study, however, has indicated that there exists a pure SIVD, in which significant subcortical white matter ischemic changes are present with no evidence of amyloid plaque deposition in the brain ().', "Alzheimer disease: PiB-PET-based studyNeurology2013805695732332591018SeoSWHwa LeeBKimEJChinJSun ChoYYoonUClinical significance of microbleeds in subcortical vascular dementiaStroke200738194919511751045719ParkJHSeoSWKimCKimGHNohHJKimSTPathogenesis of cerebral microbleeds: in vivo imaging of amyloid and subcortical ischemic small vessel disease in 226 individuals with cognitive impairmentAnn Neurol2013735845932349508920PatelBLawrenceAJChungAWRichPMackinnonADMorrisRGCerebral microbleeds and cognition in patients with symptomatic small vessel diseaseStroke2013443563612332145221MorrisJCRevised criteria for mild cognitive impairment may compromise the diagnosis of Alzheimer disease dementiaArch Neurol2012697007082231216322SperlingRAAisenPSBeckettLABennettDACraftSFaganAMToward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's diseaseAlzheimers Dement201172802922151424823PantoniLCerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challengesLancet Neurol201096897012061034524ChuiHDementia due to subcortical ischemic vascular diseaseClin Cornerstone2001340511143212125ArvanitakisZLeurgansSEBarnesLLBennettDASchneiderJAMicroinfarct pathology, dementia, and cognitive systemsStroke2011427227272121239526VintersHVEllisWGZarowCZaiasBWJagustWJMackWJNeuropathologic substrates of ischemic vascular dementiaJ Neuropathol Exp Neurol2000599319451108957127RossRThe pathogenesis of atherosclerosis: a perspective for the 1990sNature1993362801809847951828RossRAtherosclerosis--an inflammatory diseaseN Engl J Med1999340115126988716429van NordenAGvan DijkEJde LaatKFScheltensPOlderikkertMGde LeeuwFEDementia: alzheimer pathology and vascular factors: from mutually exclusive to interactionBiochim Biophys Acta201218223403492177767530ChoiSHKimSHanSHNaDLKimDKCheongHKNeurologic signs in relation to cognitive function in subcortical ischemic vascular dementia: a CREDOS (Clinical Research Center for Dementia of South Korea) studyNeurol Sci2012338398462206822031GrahamNLEmeryTHodgesJRDistinctive cognitive profiles in Alzheimer's disease and subcortical vascular dementiaJ Neurol Neurosurg Psychiatry20047561711470731032FuhJLWangSJCummingsJLNeuropsychiatric profiles in patients with Alzheimer's disease and vascular dementiaJ Neurol Neurosurg Psychiatry200576133713411617007233LooiJCSachdevPSDifferentiation of vascular dementia from AD on neuropsychological testsNeurology1999536706781048902534MoonSYNaDLSeoSWLeeJYKuBDKimSYImpact of white matter changes on activities of daily living in mild to moderate dementiaEur Neurol2011652232302144795435ChabriatHPappataSPouponCClarkCAVahediKPouponFClinical severity in CADASIL related to ultrastructural damage in white matter: in vivo study with diffusion tensor MRIStroke199930263726431058299036MatthewsPMFilippiniNDouaudGBrain structural and functional connectivity and the progression of neuropathology in Alzheimer's diseaseJ Alzheimers Dis201333Suppl 1S163S1722266901237KatoHYoshikawaTOkuNImaizumiMTakasawaMKimuraYStatistical parametric analysis of cerebral blood flow in vascular dementia with small-vessel disease using Tc-HMPAO SPECTCerebrovasc Dis2008265565621883626738YangDWKimBSParkJKKimSYKimENSohnHSAnalysis of cerebral blood flow of subcortical vascular dementia with single photon emission computed tomography: adaptation of statistical parametric mappingJ Neurol Sci2002203-2041992051241738439ShyuWCLinJCShenCCHsuYDLeeCCShiahISVascular dementia of Binswanger's type: clinical, neuroradiological and 99mTc-HMPAO SPET studyEur J Nucl Med19962313381344878113840JohnsonKAMinoshimaSBohnenNIDonohoeKJFosterNLHerscovitchPAppropriate use criteria for amyloid PET: a report of the Amyloid Imaging Task Force, the Society of Nuclear Medicine and Molecular Imaging, and the Alzheimer's AssociationJ Nucl Med2013544764902335966141JohnsonKAMinoshimaSBohnenNIDonohoeKJFosterNLHerscovitchPAppropriate use criteria for amyloid PET: a report of the Amyloid Imaging Task Force, the Society of Nuclear Medicine and Molecular Imaging, and the Alzheimer's AssociationAlzheimers Dement20139e1e162364345642NishioKIharaMYamasakiNKalariaRNMakiTFujitaYA mouse model characterizing features of vascular dementia with hippocampal atrophyStroke201041127812842044820443ShibataMYamasakiNMiyakawaTKalariaRNFujitaYOhtaniRSelective impairment of working memory in a mouse model of chronic cerebral hypoperfusionStroke200738282628321776190944LacombePOligoCDomengaVTournier-LasserveEJoutelAImpaired cerebral vasoreactivity in a transgenic mouse model of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy arteriopathyStroke200536105310581581789345RuchouxMMDomengaVBrulinPMaciazekJLimolSTournier-LasserveETransgenic mice expressing mutant Notch3 develop vascular alterations characteristic of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathyAm J Pathol20031623293421250791646DubrocaCLacombePDomengaVMaciazekJLevyBTournier-LasserveEImpaired vascular mechanotransduction in a transgenic mouse model of CADASIL arteriopathyStroke2005361131171556986247BjerkeMAndreassonURolstadSNordlundALindKZetterbergHSubcortical vascular dementia biomarker pattern in mild cognitive impairmentDement Geriatr Cogn Disord2009283483561986490948ParaskevasGPKapakiEPapageorgiouSGKalfakisNAndreadouEZalonisICSF biomarker profile and diagnostic value in vascular dementiaEur J Neurol2009162052111914664149KaerstLKuhlmannAWedekindDStoeckKLangePZerrICerebrospinal fluid biomarkers in Alzheimer's disease, vascular dementia and ischemic stroke patients: a critical analysisJ Neurol2013260272227272387743650JonssonMZetterbergHvan StraatenELindKSyversenSEdmanACerebrospinal fluid biomarkers of white matter lesions - cross-sectional results from the LADIS studyEur J Neurol2010173773821984574751SkoogIWallinAFredmanPHesseCAevarssonOKarlssonIA population study on blood-brain barrier function in 85-year-olds: relation to Alzheimer's disease and vascular dementiaNeurology199850966971956638052WallinABlennowKFredmanPGottfriesCGKarlssonISvennerholmLBlood brain barrier function in vascular dementiaActa Neurol Scand199081318322236039953WallinASjogrenMEdmanABlennowKReglandBSymptoms, vascular risk factors and blood-brain barrier function in relation to CT white-matter changes in dementiaEur Neurol2000442292351109622354RosenbergGAMatrix metalloproteinases in neuroinflammationGlia2002392792911220339455AdairJCCharlieJDencoffJEKayeJAQuinnJFCamicioliRMMeasurement of gelatinase B (MMP-9) in the cerebrospinal fluid of patients with vascular dementia and Alzheimer diseaseStroke200435e159e1621510551856RosenbergGAMatrix metalloproteinases and their multiple roles in neurodegenerative diseasesLancet Neurol200982052161916191157RosenbergGASullivanNEsiriMMWhite matter damage is associated with matrix metalloproteinases in vascular dementiaStroke200132116211681134022658WallinASjogrenMCerebrospinal fluid cytoskeleton proteins in patients with subcortical white-matter dementiaMech Ageing Dev2001122193719491158991259LaunerLJHughesTMWhiteLRMicroinfarcts, brain atrophy, and cognitive function: the Honolulu Asia Aging Study Autopsy StudyAnn Neurol2011707747802216206060SchneiderJABennettDAWhere vascular meets neurodegenerative diseaseStroke201041S144S1462087649161GorelickPBScuteriABlackSEDecarliCGreenbergSMIadecolaCVascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the american heart association/american stroke associationStroke201142267227132177843862PantoniLBianchiCBenekeMInzitariDWallinAErkinjunttiTThe Scandinavian Multi-Infarct Dementia Trial: a double-blind, placebo-controlled trial on nimodipine in multi-infarct dementiaJ Neurol Sci20001751161231083177263PantoniLdel SerTSoglianAGAmigoniSSpadariGBinelliDEfficacy and safety of nimodipine in subcortical vascular dementia: a randomized placebo-controlled trialStroke2005366196241569212564PantoniLTreatment of vascular dementia: evidence from trials with non-cholinergic drugsJ Neurol Sci200422667701553752365GottfriesCGBlennowKKarlssonIWallinAThe neurochemistry of vascular dementiaDementia19945163167808717266ErkinjunttiTRomanGGauthierSFeldmanHRockwoodKEmerging therapies for vascular dementia and vascular cognitive impairmentStroke200435101010171500179567DichgansMMarkusHSSallowaySVerkkoniemiAMolineMWangQDonepezil in patients with subcortical vascular cognitive impairment: a randomised double-blind trial in CADASILLancet Neurol200873103181829612468NohYLeeYSeoSWJeongJHChoiSHBackJHA New Classification System for Ischemia Using a Combination of Deep and Periventricular White Matter HyperintensitiesJ Stroke Cerebrovasc Dis2013Representative imaging scans of patients with pure subcortical ischemic vascular dementia (PiB-PET negative) or mixed dementia (PiB-PET positive)."] | Figure 1 Representative imaging scans of patients with pure subcortical ischemic vascular dementia (PiB-PET negative) or mixed dementia (PiB-PET positive). The first two axial fluid-attenuated inversion recovery images represent a similar degree of white matter hyperintensities of representative subjects in the PiB-negative (A) and in the PiB-positive (B) group. The T1-coronal images in the third column demonstrate a similar degree of generalized cortical atrophy, including medial temporal atrophy, in both the PiB-negative (A) and PiB-positive (B) groups. The PiB-PET scans in the fourth column demonstrate PiB-negativity and PiB-positivity scans, with the red color representing more intracranial PiB retentions. Abbreviations: PiB, 11C-Pittsburgh compound B; PET, positron emission tomography. Modified from Neurology 77(1): 18-25, 2011. | yes |
PMC9431953 | Figure_3 | oa_package/fe/94/PMC9431953.tar.gz | ['Recently, selective renal angioembolization has been preferred over surgery in hemodynamically stable patients with high-grade injury (grade III or higher) on the AAST kidney injury scale () (612).', 'Kidney injury in a 50-year-old woman who fell from a height.'] | Fig. 3 Kidney injury in a 50-year-old woman who fell from a height. CT scan shows renal laceration (grade III, American Association for the Surgery of Trauma) with active extravasation (arrow) and perirenal hematoma (arrowhead). Angiography confirms the contrast extravasation (arrow) from the left anterior renal artery, which was successfully treated with transcatheter arterial embolization using coils (arrowheads). | yes |
PMC7431516 | Figure_10 | oa_package/f4/ae/PMC7431516.tar.gz | [] | Fig. 10 A 49-year-old male with chronic pain at the Achilles tendon enthesis and suspicion of a Haglund deformity. MRI showed enthesopathy of the Achilles tendon (dashed arrow) and BME in the tuber calcanei (arrow) without evidence of a Haglund deformity (curved arrow) | yes |
PMC11483923 | Figure_6 | oa_package/3e/20/PMC11483923.tar.gz | [] | FIGURE 6 Decrease in triacylglycerol (TG) levels on the auricle skin surface of hamsters treated topically with a 2% ozenoxacin lotion. The lotion containing 2% ozenoxacin or a placebo was topically applied to both sides of the right auricle skin of hamsters once a day for 14days. (a) The auricle tissues were fixed and stained with Oil Red O on day 15. Image analysis software evaluated the ratio of the total area of sebaceous glands to section length (b) and epidermis thickness (c) from three individual evaluation fields per tissue. (d) The right auricle skin was wiped with an acetoneimpregnated cotton on day 15. One hour after wiping, sebum on the skin surface was extracted three times with 3mL of acetone for 1min using glass test tubes. An automatic thinlayer chromatography, Iatroscan, was used to analyze TG levels in the sebum from the skin surface of the hamster auricles. Data are presented as meansstandard deviation of tissues from 5 to 6 animals. * <0.05 compared with placebo (Fisher's least significant difference test). | yes |
PMC5484604 | Figure_2 | oa_package/5d/f8/PMC5484604.tar.gz | ['In addition, a high number of stromal vascular cells were observed residing between the adipocytes (A).', 'Perl s Prussian blue staining showed robust iron retention in the adipocytes as well as stromal vascular cells infiltrated to the adipose tissue (A 2B).', "By using Masson's trichrome stain for collagen fibers, we observed a significant amount of collagen fiber staining present among adipocytes in HI compared with NI (A 2B).", 'In addition, Caspase 3 staining suggests greater apoptosis in eAT of the HI group (A 2B).', 'g002A robust tissue remodeling in the HI mice epididymal fat pads.'] | 10.1371/journal.pone.0179889.g002 | yes |
PMC10509735 | Figure_7 | oa_package/65/3e/PMC10509735.tar.gz | ['3DHistoNet can identify common features responsible for the strong positive correlation between ER and PR expressions.', 'DiscussionPrincipal FindingsBreast cancer subtyping is a crucial step in determining therapeutic options, but the molecular examination based on IHC staining is expensive and time-consuming.'] | Figure 7 3DHistoNet can identify common features responsible for the strong positive correlation between ER and PR expressions. (A) In the ER+/PR+ image, low-grade cancer cells with ductal differentiation were commonly highlighted (orange box), whereas amorphous features of fibroblast and stroma were paid less attention (red box). (B) In the ER/PR image, the less growth pattern of the high-grade tumor cells was assigned brighter coloration (higher weightage, orange box), whereas cells along the blood vessels were assigned darker coloration (red box). ER: estrogen receptor; PR: progesterone receptor. | yes |
PMC9498659 | Figure_4 | oa_package/d6/38/PMC9498659.tar.gz | ['The most prominent radiological manifestations included the deformities of the femoral heads ().', 'Early radiological changes in the hip joints of the patients with MED type 4.'] | Figure 4 Early radiological changes in the hip joints of the patients with MED type 4. ( ) Anteroposterior radiograph of the hips of the two 5-year-old patients: remarkably delayed ossification of the epiphyses of the femoral heads (white arrows), shortening of the femoral necks (black arrows). ( ) Anteroposterior radiograph of the hips of the 6-year-old patient: abnormal ossification (diminished size and flattening) of the epiphyses of the femoral heads (white arrows), shortening of the femoral neckscervical coxa vara (black arrows). | yes |
PMC4633078 | Figure_2 | oa_package/6e/25/PMC4633078.tar.gz | ["The echogenicity and the thickness of the dermis are variable, according to the\npatient's age ().", 'HFUS, cross sectional view, anterior region of the right forearm in consanguineous\npatients with a single skin phototype.'] | Figure 2 HFUS, cross sectional view, anterior region of the right forearm in consanguineouspatients with a single skin phototype. 3-year-old patient. Thinepidermis and 1.45 mm-thick dermis. 25-year-old patient. Dermismeasuring 1.22 mm in thickness. 55-year-old patient. Epidermalthickening and 1.03 mm-thick dermis. | yes |
PMC4947121 | Figure_8 | oa_package/60/48/PMC4947121.tar.gz | [' 8b) and strongly reduced A levels (', ' 8a), FCA18, 6E10 (not shown) and 4G8 (', 'Error bars represent SEM\nFurthermore, and more surprisingly, in the C99-expressing mouse, D6 not only led to an enhanced staining in the cortex and subiculum, the two main regions expressing C99, but it also induced a strong immunostaining in various other brain regions, in which very low or no C99 staining was seen in vehicle-treated AAV-C99 mice (', ' 8a).', ' 8b, c), while this was not the case in those from D6-treated AAV-GFP mice (', ' 8d), again indicating that these lysosomal alterations were linked to C99 expression.', ' 8e, f, but see also ', ' 8e, f).', ' 8g) and GFAP-positive astrocytes (', ' 8h).', ' 8g).', ' 8h) were not induced by D6 in AAV-empty mice.', ' 8i k).', ' 8i), only the AAV-empty mice displayed a robust induction in LTP (', ' 8j, k).'] | Fig.8 -Secretase inhibitor treatment of AAV-C99 expressing mice leads to exacerbated autophagic dysfunction, inflammatory responses and synaptic dysfunction. Brain slices at the levels of the subiculum from vehicle- (Veh) or D6-treated AAV-C99 mice were immunostained with 82E1 and -CatB. 25m. Western blot analysis of RIPA-soluble fractions from AAV-C99 injected mice ( , ) or AAV-GFP mice ( ) treated with D6 or vehicle (Veh). Brains were analyzed for APP-CTF (using either -APPct or 6E10) or LC3-I/LC3-II expression. in correspond to the quantitative analysis of LC3-II, expressed as the LC3-II/LC3-I ratio, and are relative to control (AAV-C99-Veh). MannWhitney test, <0.001, =8. corresponds to AAV-C99 mice. , Immunostaining with 4G8 or NU1 of D6-treated AAV-C99 brains using fluorescence ( ) or peroxidase-DAB labeling ( ). Note the extracellular staining ( in and in ) surrounding pycnotic nuclei visualized by DAPI ( , ) or Cresyl violet ( , ). 50 or 10m, respectively. , Immunostaining with 4G8, Iba1 ( ) or GFAP ( ) reveals both microglial and astrocytic activation in D6-treated mice within brain regions expressing important APP-CTF levels. 300 and 50m, respectively. Basal synaptic transmission in AAV-empty, vehicle-treated AAV-C99 or D6-treated AAV-C99 mice ( =23 slices per mouse from 6 to 7 mice per group. All values are meanSEM. Field excitatory postsynaptic potential (fEPSP) slopes in subiculum ( =23 slices per mouse from 6 to 7 mice per group). Summary graph of LTP magnitudes calculated 40 to 60min after high-frequency stimulation from graphs in ( ) with statistical analysis (* <0.05; one-way ANOVA with the Tukeys post hoc test). represent SEM | yes |
PMC9300938 | Figure_4 | oa_package/1a/6f/PMC9300938.tar.gz | [] | Figure4 Upper abdominal enhanced CT in December 3, 2020; the right kidney was not shown and the left kidney appeared to have a new low-density mass, about 11mm in diameter, with marginal enhancement. In February 18, 2021, after more than 2 months of crizotinib withdrawal, the patient revealed that the abnormal enhancement of the left kidney was not obviously displayed. | yes |
PMC5267603 | Figure_4 | oa_package/f0/a3/PMC5267603.tar.gz | [' demonstrates examples taken from the UCSF and publicly available test sets and the classification probabilities produced by the algorithm.', 'Images are all from either the UCSF test set or publicly available set\nThe cutoff was set to J = 99.'] | Fig. 4 Example test images and classification results. Examples of frontal and lateral images are shown with their frontal and lateral prediction probabilities listed underneath each. Images are all from either the UCSF test set or publicly available set | yes |
PMC11004415 | Figure_6 | oa_package/5a/18/PMC11004415.tar.gz | [' presents the cerebellar MRS data for patients diagnosed with MSA-C (labeled as A-F) or SCA2 (labeled as G-L), encompassing a range of disease durations and SARA scores, and indicating the presence or absence of HCBS.', 'A 69-year-old female diagnosed with MSA with her disease duration of 1 year and a SARA score of 7 had an MRI of her brain that showed the presence of an HCBS (A), and the MRS (', 'A 74-year-old female MSA patient, who has been living with the disease for 5 years and has a SARA score of 18, had an MRI that revealed an HCBS (C), and the MRS (', 'A 72-year-old female with MSA with a disease duration of 5 year and a SARA score of 25 had an MRI that presents an HCBS (E), and the MRS (', 'A 73-year-old male diagnosed with SCA2 with his disease duration of 2 year and a SARA score of 3 underwent an MRI that disclosed no HCBS (G), and the metabolites ratios in his cerebellum (', 'A 47-year-old female with SCA2 with a disease duration of 5 years and a SARA score of 12 had an MRI that showed the presence of an HCBS (I), and the MRS (', 'A 53-year-old woman diagnosed with SCA2, having lived with the condition for 8 years and holding a SARA score of 24, underwent an MRI that identified a HCBS (K).', 'Further, the MRS results for her cerebellum (L) demonstrated a NAA/Cr ratio of 0.', 'This figure showcases axial FLAIR images of the pons and cerebellar MRS data for patients diagnosed with MSA-C (A F) and SCA2 (G L), categorized by disease duration and segmented according to SARA scores into three ranges: 0 11 (A, B, G, H), 12 20 (C, D, I, J), and over 21 (E, F, K, L).', '4DiscussionPatients with MSA-C often present with clinical symptoms similar to those observed in SCA2 [4].'] | Fig. 6 This figure showcases axial FLAIR images of the pons and cerebellar MRS data for patients diagnosed with MSA-C (AF) and SCA2 (GL), categorized by disease duration and segmented according to SARA scores into three ranges: 011 (A, B, G, H), 1220 (C, D, I, J), and over 21 (E, F, K, L). Through showcasing patient profiles from the early to advanced stages of MSA-C and SCA2, highlight the utility of MRS readouts in differentiating between these conditions at various stages of disease progression, demonstrating the potential of specific metabolite ratios as diagnostic markers. | yes |
PMC11515493 | Figure_6 | oa_package/92/b3/PMC11515493.tar.gz | [' 6A, B).', ' 6C, D).', '\nRaptor knockdown reduced tau protein levels through the activation of autophagy in vitro.', '0001\nRaptor knockdown also reduced total tau levels and decreased phosphorylation at Ser404, Ser396, and Thr205 (', ' 6E, F).', ' 6G, H).', ' 6I-K).'] | Fig. 6 Raptor knockdown reduced tau protein levels through the activation of autophagy in vitro. ( , ) Western blot analysis and quantitative analysis of Raptor, mTOR, p-P70 S6K, P70 S6K, P62, and LC3 expression in HEK293T/P301S cells 24h after transfection with shRaptor. =3 per group. ( , ) Representative electron microscopy images showing the number of autophagosomes in cells (red arrow indicates an autophagosome fusing with a lysosome) and quantitative analysis of autophagosome numbers. =9 images per group. ( , ) Western blot analysis and quantitative analysis of total tau protein and phosphorylated tau protein levels in HEK293T/P301S cells 24h after transfection with shRaptor. =3 per group. ( , ) Representative fluorescence microscopy images of tau protein expression in HEK293T-Tau cells 24h after transfection with shRaptor, along with the corresponding quantitative analysis. =5 per group. ( ) Western blot analysis of Raptor, total tau protein, phosphorylated tau protein, P62, and LC3 in sarkosyl-soluble and sarkosyl-insoluble protein fractions extracted from HEK293T-P301S cells. =3 per group. ( ) Quantification of protein levels in the sarkosyl-soluble fraction. ( ) Quantification of protein levels in the sarkosyl-insoluble fraction. Unpaired t-tests were used for data analysis in all panels. All data were presented as meanSEM. ns indicates no statistically significant difference, * <0.05, ** <0.01, *** <0.001, **** <0.0001 | yes |
PMC10789373 | Figure_26 | oa_package/bf/e5/PMC10789373.tar.gz | [] | Figura 14.1 Mecanismos envolvidos na disfuno atrial esquerda avaliada pelo strain. | yes |
PMC10564677 | Figure_4 | oa_package/3d/4d/PMC10564677.tar.gz | [' 4a).', ' 4a, b).', 'IBM demonstrates a pronounced loss of type 2A muscle fibers.', 'ACHE acetylcholine esterase; CHRNA1 cholinergic receptor nicotinic alpha 1 subunit; FAP fibro-adipogenic progenitor; HLA human leukocyte antigen; IMNM immune-mediated necrotizing myopathy; MYH myosin heavy chain; MuSC muscle stem cell; NDC non-diseased control; IBM inclusion body myositis; TNFAIP2 TNF Alpha Induced Protein 2; UMAP uniform manifold approximation and projectionTo gain further insight into the phenotype of myogenic cells in IBM, we extracted the myonuclei from the full dataset (', ' 4c) and performed subclustering on these nuclei (', ' 4d).', ' 4e).', ' 4f).', ' 4g, Suppl.', 'An exemplary set of staining is given in .'] | Fig. 4 IBM demonstrates a pronounced loss of type 2A muscle fibers. UMAP embedding of the full dataset split into IBM (left) and NDC (right). Cell populations are indicated by their colour code. Relative frequency of each cell type or subtype in the IBM and the NDC dataset as a stacked bar plot. UMAP embedding of the full dataset. Myonuclei are highlighted in dark red. These nuclei were extracted for downstream analysis UMAP embedding of the myonuclei subclusters. A total of five populations were obtained from subclustering. Clustered dot plot visualization of top-regulated marker genes. The mean expression for each cluster is indicated by colour code. The dot size indicates the percent of expressing cells. Clusters were annotated based on marker genes. UMAP embedding for the myonuclei subcluster split into the IBM (left) and NDC (right) datasets. Subclusters are colour coded. Exemplary ATPase staining for muscle specimens obtained from NDC, IBM, and IMNM patients. 8 patients were analysed by ATPase staining for each group. Muscle slices were incubated at a pH of 4.6, inactivating the myosin-ATPase of specific muscle fiber types. Type 1 muscle fibers are dark brown, type 2A is light brown, and type 2X are of an intermediate colour. The contrast and intensity vary between muscle specimens. A total of 10 high-power fields were counted. The corresponding statistical analysis is displayed in Suppl. Fig.1B. acetylcholine esterase; cholinergic receptor nicotinic alpha 1 subunit; fibro-adipogenic progenitor; human leukocyte antigen; immune-mediated necrotizing myopathy; myosin heavy chain; muscle stem cell; non-diseased control; inclusion body myositis; TNF Alpha Induced Protein 2; uniform manifold approximation and projection | yes |
PMC11327419 | Figure_1 | oa_package/fa/57/PMC11327419.tar.gz | ['Pathological view of pelvic endometriosis lesionsVulvar endometriosis lesionsCase PresentationA 64-year-old woman with BMI of 29 kg/m2 (weight=68 kg, height=165 cm) and without any underlying diseases presented to the clinic.'] | Figure 1 Pathological view of pelvic endometriosis lesions | yes |
PMC2722197 | Figure_3 | oa_package/c8/4c/PMC2722197.tar.gz | ['These actions of CAM (summarized in ) show that different herbal and nutritional remedies are available to prevent the binding of tick to skin, to reduce bacterial load by enhancement of NK cell activity and phagocytosis, to down-regulate proinflammatory cytokines and inhibit the fibrinolytic system, and repair the BBB.', '.'] | Figure 3. Using CAM treatment could prevent different processes ranging from the attachment of the tick to the inflammatory process, CNS invasion, and the induction of neuroborreliosis. CAM can act through the enhancement of natural killer cell activity, macrophage function, inhibition of pro-inflammatory cytokine production, inactivation of the fibrinolytic system, and repair of blood brain barriers. | yes |
PMC7772605 | Figure_3 | oa_package/15/30/PMC7772605.tar.gz | ['The main complications of NU are local skin infections and osteomyelitis.'] | Figure 3 Diabetic patient: (A), scar of arterial ulcer (*) on the left foot and neuropathic ulcer over the first right metatarsal; (B), thinned peripheral calluses. | yes |
PMC10932355 | Figure_5 | oa_package/30/66/PMC10932355.tar.gz | ['Gemination of a tooth germ results in partial twinning of a tooth germ during development ().', 'Geminated primary lower lateral incisor shown radiographically (*) and photographically following extraction.'] | Figure 5 Geminated primary lower lateral incisor shown radiographically (*) and photographically following extraction. When counted as one tooth, the patient had the appropriate number of teeth, confirming this was a geminated tooth as opposed to the fusion of two teeth. | yes |
PMC11431435 | Figure_7 | oa_package/b2/5c/PMC11431435.tar.gz | ['The cartilage is mainly fibrocartilage, as revealed by the morphology of the cartilage cells in Safranin O, Alcian blue, Herovici s, and H E staining (A D).', 'Microscopic verification of the cartilage category with the sagittal sections: (A) Superior part of midline.'] | Figure 7 Microscopic verification of the cartilage category with the sagittal sections: ( ) Superior part of midline. Safranin O staining showed strong orange staining with fibrocartilage morphology. Alcian blue staining also revealed strong blue staining with fibrocartilage-like cells. Herovicis staining showed light blue staining in the cell body and mixed red and blue staining in the matrix. H&E staining also showed a blue matrix in the cartilage area. ( ) Superior part at the 3 mm axial level. At this level, only part of the tissue was stained Safranin O-positive between the trabecular bone and tendon tissues for Safranin O, Alcian blue, Herovicis, and H&E staining. ( ) Four sections were stained at the inferior part of the midline. Safranin O staining revealed a strongly orange-stained cartilage matrix with fibrocartilage cell morphology. Alcian blue staining revealed a scattered Alcian blue-positive matrix. Herovicis staining showed a mixed red and blue matrix. H&E staining revealed a blue matrix of fibrocartilage. ( ) Four sections of the inferior 3 mm axial region. Safranin O staining revealed an orange-colored cartilage matrix. Similar results were observed for the Alcian blue staining. Herovicis staining revealed mainly a red collagen matrix. H&E staining revealed mainly red staining in the trabecular bone and tendon. Scale bar = 200 m. | yes |
PMC9339632 | Figure_2 | oa_package/48/ca/PMC9339632.tar.gz | ['Intraoperatively, a space-occupying lesion about 5 5 4 cm in size was observed at the upper parts of the right kidney, the capsule was intact, and the boundary with surrounding normal renal tissue was good (A).', '(A) Lesion tissue specimen: Multiple central necrotic granulomas in the medulla of renal tissue can be seen, and pus can be seen in the necrotic area, (the red arrow:pus); (B) Histopathological examination, low magnification (HE, 5 ) abscess formation in the renal parenchyma, with fibrin in the center Necrotic tissue, surrounded by foam cells, fibrous tissue hyperplasia, and surrounding.'] | Figure 2 Lesion tissue specimen: Multiple central necrotic granulomas in the medulla of renal tissue can be seen, and pus can be seen in the necrotic area, (the red arrow:pus); Histopathological examination, low magnification (HE, 5) abscess formation in the renal parenchyma, with fibrin in the center Necrotic tissue, surrounded by foam cells, fibrous tissue hyperplasia, and surrounding. High magnification (HE, 100), a large number of foam cells reacted around the abscess necrosis. (the red arrow:foam cell). Postoperative follow-up CT showed good preservation of renal structure and function. axial image; coronal image, (the red arrow: postoperative renal). | yes |
PMC8431702 | Figure_2 | oa_package/7b/1b/PMC8431702.tar.gz | ['In total, 76 cores were taken and analyzed using FCM ().', 'Digital Biopsy images.'] | Figure 2 Digital Biopsy images. High-resolution pictures allow zooming into focal areas to better evaluate the architecture of the prostatic gland. ( ) Negative core and zoom into normal gland architecture. ( ) Positive core, Gleason Grade Group 4, pattern 4. | yes |
PMC10731363 | Figure_2 | oa_package/2a/10/PMC10731363.tar.gz | ['However, after the procedure, the imaging doctor was invited to analyze the films again, which led to the discovery of an intravenous tumor thrombus ().', 'Image of thorax, abdomen, and pelvic CT scan.', 'While performing surgery, the vascular surgeon was consulted on the stage, analyzed the imaging report again, and considered an intravenous neoplasms thrombus ().'] | Figure 2 Image of thorax, abdomen, and pelvic CT scan. (A) Coronal CT imaging shows tumor thrombus (arrow) in Inferior vena cava; (B) sagittal CT imaging shows tumor thrombus (arrow) in Inferior vena cava; (C) coronal CT imaging showing tumor thrombus (arrow) in the left common iliac vein. CT, computed tomography. | yes |
PMC11441076 | Figure_2 | oa_package/8c/b0/PMC11441076.tar.gz | ['.'] | Figure 2. Identifying new neurofibrillary tangle formation in live mice (A) Image volumes were aligned and cropped to enable quantitative assessment of tangle formation and neuron death across weeks. (B) New tangles were identified based on the appearance of HS-84-labeled objects that were not present the previous week. Image shows labeled neuronal nuclei in magenta, intravenous dextran-labeled blood vessels in red, and tangles in white. Higher magnification images of the boxed area from each week are shown in panels (iiv). The blue box shows a new tangle appearing on week 3, and the magenta box shows new tangles appearing on week 4. (C) All new tangles were registered and pseudo-colored based on their week of appearance: week 1 (yellow), week 2 (cyan), week 3 (blue), and week 4 (magenta). | yes |
PMC5554664 | Figure_1 | oa_package/c4/d2/PMC5554664.tar.gz | ["Cette particularit de la contraction myocardique constat e l'imagerie a donn le nom ce syndrome dont la traduction litt rale japonaise tako : poulpe tsubo : pot , correspond un pi ge ancestral utilis par les p cheurs japonais dont la forme ressemble celle du ventricule gauche pendant la systole () [1].", 'L aspect du c ur dans la cardiomyopathie de stress (syndrome de Tako-Tsubo)Patient et observationMme Z.'] | Figure 1 Laspect du cur dans la cardiomyopathie de stress (syndrome de Tako-Tsubo) | yes |
PMC7682919 | Figure_3 | oa_package/ea/0c/PMC7682919.tar.gz | ['Axial view computed tomography scan of chest with contrast demonstrating 10.'] | Figure 3 Axial view computed tomography scan of chest with contrast demonstrating 10.7 cm x 4 cm x 10.1 cm mass (white arrow) inseparable from the right heart border pericardium, displacing the heart to the left with associated compression of the superior right atrium and the superior vena cava | yes |
PMC5563341 | Figure_5 | oa_package/f5/79/PMC5563341.tar.gz | [' 5).', ' 5).', '', 'Scale bar is indicated (a, top left panel)\nCorrelation of TCR repertoire between TCL generated from distinct lesions of the same MS patientThe markers expressed by CD8+ T cells in WML suggest antigen-driven activation and potentially retention of specific TCC in affected tissue of MS patients (Figs.'] | Fig.5 CD8 T cells interact with all major brain-resident cell types in white matter lesions of MS patients. Representative double-immunofluorescence stainings on 8-m sections of 12 formalin-fixed paraffin-embedded white matter lesion (WML) tissues from 10 MS patients are shown for glial fibrillary acidic protein (GFAP: marker for astrocytes); ionized calcium-binding adapter molecule 1 (Iba1: marker for microglia); proteolipid protein (PLP: marker for oligodendrocytes) and neurofilament heavy chain (NF-H: marker for neurons; ) combined with CD8 ( ), counterstained with 4,6-diamidino-2-phenylindole (DAPI; ) and finally analyzed using a Zeiss LSM-700 confocal laser microscopy and ZEN software. Perivascular CD8 T cells interact with astrocytes ( and ) and microglia ( and ). Parenchymal CD8 T cells also interact with astrocytes ( ), microglia ( ) and oligodendrocytes ( ) in fully myelinated ( ) and partially demyelinated areas ( and ). Parenchymal CD8 T cells also interact with neurons ( ) in areas without ( ), with moderate ( ) and with prominent axonal swelling ( ). The latter is indicative of axonal damage. show specific interactions between CD8 T cells and the major brain-resident cells analyzed for. is indicated ( , ) | yes |
PMC4222415 | Figure_1 | oa_package/24/4c/PMC4222415.tar.gz | ['12 14The majority of patients with TTP show severe deficiency in the VWF-cleaving activity of ADAMTS-13, either caused by missense or frame-shift mutations14 16 (B) or due to ADAMTS-13 neutralizing autoantibodies.', '17,18.', 'Von Willebrand factor is released from endothelial cells as ultra-large multimers of VWF (UL-VWF) which can bind the glycoprotein (GP) Ib components of platelet GPIb-IX-V receptor and induce platelet adhesion and aggregation by shear stress in the arterioles and capillaries (B).', '22In normal subjects, the UL-VWF molecules are cleaved by a specific VWF-cleaving metalloprotease present in the plasma, ADAMTS-13 (A).'] | Figure 1. In Panel A, in normal subjects, ADAMTS-13 (von Willebrand factorcleaving metalloprotease) molecules attach to binding sites on endothelial cell surfaces and cleave unusually large multimers of von Willebrand factor as they are secreted by stimulated endothelial cells. The smaller von Willebrand factor forms that circulate after cleavage do not induce the adhesion and aggregation of platelets during normal blood flow. The ADAMTS-13 may use one of its thrombospondin-1like domains or its arginineglycineaspartate (RGD) sequence to attach to the surface of endothelial cells. In Panel B, absent or severely reduced activity of ADAMTS-13 in patients with thrombotic thrombocytopenic purpura prevents timely cleavage of unusually large multimers of von Willebrand factor as they are secreted by endothelial cells. The uncleaved multimers induce the adhesion and aggregation of platelets in flowing blood. A congenital deficiency of ADAMTS-13 activity or an acquired defect of ADAMTS-13 (such as that caused by autoantibodies or by a change in the production or survival of the protein) can lead to thrombotic thrombocytopenic purpura. Interference with the attachment of ADAMTS-13 to endothelial cells (for example, as a result of ADAMTS-13receptor blockade by other types of autoantibodies) may also cause thrombotic thrombocytopenic purpura in patients with normal ADAMTS-13 activity in plasma. From: Moake JL. Thrombotic microangiopathies. N Engl J Med 2002;347:587600. Copyright Massachusetts Medical Society. Reprinted with permission from Massachusetts Medical Society. | yes |
PMC7044032 | Figure_3 | oa_package/e8/9c/PMC7044032.tar.gz | ['Compared with controls, 3TG HF had significant lower levels of total soluble tau and its phosphorylated isoforms ( A, B).', 'These findings were confirmed by immunohistochemistry analyses showing that brain sections of 3TG HF mice had lower immunoreactivity to tau and the phosphorylated tau epitopes ( G, H).', 'Additionally, 3TG HF offspring had a significant decrease in the levels of formic acid-soluble tau (insoluble tau) when compared with control mice ( C, D).', 'In agreement with this finding we observed that in the same mice the immunoreactivity to tau aggregation-prone isoforms, as recognized by MC1 antibody (27), was also significantly reduced ( G, H).', 'Compared with controls, brains from 3TG HF offspring had a significant decrease in tau mRNA levels ( I), suggesting a transcriptional regulation of this gene by the diet.', 'Levels of the kinase CDK5 along with its active forms p35 and p25 were reduced in 3TG HF when compared with controls ( E, F).', 'Additionally, the same group had a significant decrease in the levels of total GSK3 and GSK3 , but no changes were detected in their phosphorylated isoforms ( E, F).', 'Interestingly, while compared with controls 3TG HF mice showed significant reduction in the mRNA levels for CDK5, no changes were observed in the mRNA levels for GSK3 and GSK3 ( I).', ':Effect of gestational high fat diet on tau brain pathology.'] | Figure 3: Effect of gestational high fat diet on tau brain pathology. Protein levels of RIPA soluble and phosphorylated tau measured by western blot analysis in brain cortex of 12 months old 3TG HF and 3TG CTR offspring (A). Densitometry of previous panel (B). Protein levels of formic acid soluble tau measured by western blot analysis in brain cortex of 12 months old 3TG HF and 3TG CTR offspring (C). Densitometry of previous panel (D). Protein levels of CDK5, P25, P35, GSK3, GSK3, pGSK3, pGSK3 measured by western blot analysis in brain cortex of 12 months old 3TG HF and 3TG CTR offspring (E). Densitometry of previous panel (F). Immunoreactivity to tau, phosphorylated tau and aggregation prone tau measured in brain sections of 12 months old 3TG HF and 3TG CTR offspring (G). Quantification of immunoreactivity shown in previous panel (H). Human tau (MAPT), CDK5 and GSK3/ mRNA levels measured by rt-PCR in brain cortex of 12 months old 3TG HF and 3TG CTR offspring (I). Results are mean sem. * = p < 0.05. Western blot molecular weight: see . | yes |
PMC11439839 | Figure_5 | oa_package/08/ac/PMC11439839.tar.gz | ['The pathology report revealed a high-grade angiosarcoma (Fig 5).', 'Upon reviewing the slides, the pathologist identified atypical vascular proliferation within the surrounding cells from the original aortic thrombus consistent with a portion of angiosarcoma (Fig 5).', 'Fig 5Pathology slide showing atypical endothelial cells infiltrating in the aortic thrombus consistent with angiosarcoma.'] | Fig5 Pathology slide showing atypical endothelial cells infiltrating in the aortic thrombus consistent with angiosarcoma. | yes |
PMC11471187 | Figure_4 | oa_package/f7/55/PMC11471187.tar.gz | ['10 Currently, MRI and CT are the most used modalities ().', 'Axial sections of different radiological imaging modalities of the brain demonstrating the AWC location and contours; T2 weighted MRI (A,B,C), Flair MRI (D,E), T1 weighted MRI (F), CT (G).', 'US of the AWC is a great modality to diagnose many pathologies during prenatal screening.'] | Fig. 4 Axial sections of different radiological imaging modalities of the brain demonstrating the AWC location and contours; T2 weighted MRI ( , , ), Flair MRI ( , ), T1 weighted MRI ( ), CT ( ). Yellow arrows point to the AWC on both sides of each figure. | yes |
PMC11412753 | Figure_6 | oa_package/92/ef/PMC11412753.tar.gz | ['75-mm anchor ().', '005" position="float"/>Arthroscopic view from the anterolateral portal demonstrating a reduced medial meniscus following transtibial root repair.'] | Figure 6 Arthroscopic view from the anterolateral portal demonstrating a reduced medial meniscus following transtibial root repair. | yes |
PMC6794093 | Figure_9 | oa_package/92/68/PMC6794093.tar.gz | [] | 10.7554/eLife.50069.015 | yes |
PMC7473568 | Figure_4 | oa_package/0d/35/PMC7473568.tar.gz | ['g004Semiquantitative scores by distribution and imaging stage.'] | 10.1371/journal.pone.0238760.g004 | yes |
PMC9552960 | Figure_7 | oa_package/40/98/PMC9552960.tar.gz | ['Next, principal component analysis of NCoR1 and SMRT KD cDC1 RNA-seq clearly showed SMRT KD unstimulated and 6h CpG stimulated condition cluster separately from respective NCoR1 samples (\nSupplementary A\n).', 'Nurr-77, mTOR, Stat3 signaling regulates IL-10 expression in SMRT KD cDCs.', 'We observed reduction in p-STAT3 binding on Il10 in SMRT KD DCs relative to control DCs whereas on the other side, the binding was found to be enhanced in NCoR1 KD cells as compared to control cells (\nE\n).', 'SMRT KD leads to downregulation of Nr4a1 while NCoR1 KD has no significant effect on expression of Nr4a1 (\nH\n).', 'Further we checked direct binding of NCoR1 and SMRT on Nr4a1 in ChIP-seq data using IGV browser and observed that SMRT but not NCoR1 binds at the TSS of the transcript that is expressed in DCs after 6h CpG activation (\nH\n).', 'Moreover, in these NR4A1 depleted DCs we also confirmed significant reduction of IL-10 percent positive cells and corresponding MFI shifts upon 6h CpG treatment (\nM\n).', 'We found that 6-MP treatment enhanced the expression of Nr4a1 in SMRT depleted cDC1 leading to an increase in expression of Il10 (\nN\n).'] | Figure 7 Nurr-77, mTOR, Stat3 signaling regulates IL-10 expression in SMRT KD cDCs. Illustration of Jak/Stat Signaling pathway from Ingenuity pathway analysis with mapped expression of genes. (Red and green indicate high and low expression respectively). RNA-seq analysis showing heatmap showing Log2 (fold change) of all the genes in KEGG Jak-Stat signaling term shown in Fig 6L. Western blot depicting phospho-STAT3, total STAT3, and -actin protein levels in unstimulated and 2h and 6h CpG stimulated control, NCoR1 KD, and SMRT KD cDC1. Bar plot with standard error mean from densitometric analysis depicting normalized intensity of phosphorylated STAT3 bands in control and KD cDC1. Housekeeping gene -actin was used as loading control (n=3). Bar plot with standard error mean showing % input enrichment from ChIP-qPCR of phospho-STAT3 on IL-10 enhancer region in 2h CpG stimulated control, NCoR1 KD, and SMRT KD cDC1. (n=3) Western blot depicting the levels of phosphorylated mTOR, total mTOR, and GAPDH in unstimulated, 2h, and 6h CpG stimulated control, NCoR1 KD, and SMRT KD cDC1. Housekeeping gene GAPDH was used as loading control. Bar plot with standard error mean from densitometric analysis depicting normalized intensity of phosphorylated mTOR bands in control and KD cDC1. Housekeeping gene GAPDH was used as loading control (n=3). Bar plot with standard deviation showing normalized count of gene in NCoR1 and SMRT KD cDC1 with their respective matched controls in 6h CpG stimulation. IGV snapshot showing SMRT and NCoR1 binding at gene loci in control unstimulated and 6h CpG stimulated DCs along with RNA-seq in control, SMRT KD and NCoR1 KD DCs in 6h CpG stimulation condition. Western blot depicting the levels of NR4A1 and -actin in unstimulated, 2h, and 6h CpG stimulated control and SMRT KD cDC1 (n=3). Bar plot with standard error mean from densitometric analysis depicting the normalized intensity of NR4A1 bands in KD and control cells. Housekeeping gene -actin was used as loading control (n=3). Western blot depicting the levels of phospho-mTOR, total mTOR, phospho-STAT3, total STAT3, NR4A1, and -actin in 2h CpG stimulated control and NR4A1 KD cDC1. Bar plot with standard error mean from densitometric analysis depicting the normalized intensity of phosphorylated-mTOR, phosphorylated-STAT3, and NR4A1 in 2h CpG stimulated control and NR4A1 KD cDC1. Housekeeping gene -actin was used as loading control (n=4). Percent positive cells and MFI depicting flow cytometry analysis of the anti-inflammatory cytokine IL-10 in 6h CpG stimulated control and NR4A1 KD DCs. (n=6) Relative transcript expression of , , , and transcript in 6h CpG-B stimulated SMRT KD, CpG along with vehicle treated SMRT KD and CpG along with 6-MP treated SMRT KD DCs as estimated by RT-qPCR (n=3). *p 0.05 and **p 0.01. p-value has been calculated using two tailed paired students t-test. Data shown in figure is combined from 3-4 independent experiments , four independent experiments , and three independent replicates . Error bars represent SEM. "ns" stands for non significant. | yes |
PMC11132649 | Figure_2 | oa_package/81/82/PMC11132649.tar.gz | ['Surgical SAMENs were distinguished from ATA USRSS low risk isoechoic nodules by virtue of suspicious nodule margins (35/60; 58%), microcalcifications (31/60; 52%) and taller-than-wide US geometry in the transverse US view (10/60; 17%) (see ).', 'The most common echogenicity and atypical feature combination seen in our 40 excised thyroid cancers was isoechoic with microcalcifications (28/40; 70%) (see c).', ':SAMEN US patterns\n(a): A thick, irregular, hypoechoic capsule surrounding an isoechoic/hyperechoic lobulated classical papillary thyroid cancer in a 34-year-old male; (b) an isoechoic microcalcified (white oval) irregular-bordered follicular-variant of papillary thyroid cancer in a 76-year-old female; (c) a taller-than-wide isoechoic nodule in a 67-year-old male with classical papillary thyroid cancer.', 'iso-, hetero-, hyper-and mixed echogenicity) with associated atypical features that include microcalcifications, suspicious borders and taller-than-wide geometry in the transverse US plane (see ).', '15ConclusionsNC ATA SAMENs are mostly isoechoic nodules that also exhibit atypical features more commonly seen in classical papillary thyroid cancer including: microcalcifications, irregular boundaries and (3) taller than wide geometry ().'] | Figure 2: SAMEN US patterns | yes |
PMC8724814 | Figure_2 | oa_package/48/85/PMC8724814.tar.gz | ['The trained algorithm outputs a bounding box identifying a region of interest (figure 2), along with a malignancy score quantifying the likelihood that the region of interest represents a malignancy.', 'Digital mammogram mediolateral oblique view with region of interest (denoted by bounding box) identified by the AI algorithm as suspicious for malignancy.'] | Figure 2 Digital mammogram mediolateral oblique view with region of interest (denoted by bounding box) identified by the AI algorithm as suspicious for malignancy. Cancer was confirmed as invasive ductal carcinoma. AI, articial intelligence. | yes |
PMC6064762 | Figure_1 | oa_package/0f/c9/PMC6064762.tar.gz | ['A submental flap and reconstruction plate without bone grafting had been used in five patients, and a combination of a free bone graft and reconstruction plate was applied in the other six cases ().', '(a) Submental flap is used for coverage of reconstruction plate and free bone graft in a gunshot victim.'] | Fig1 (a) Submental flap is used for coverage of reconstruction plate and free bone graft in a gunshot victim. (b) The hairy part is used for reconstructing through and through skin defect. (c) The deepithelialized part of the flap is used for intraoral reconstruction. (d) Photograph taken 2 months after surgery shows complete epithelialization of the submental flap. (e) Birds-eye view 1 year after surgery shows the hairy part of the submental flap. The avulsed nose is replaced by an implant-supported nasal prosthesis | yes |
PMC9316585 | Figure_2 | oa_package/cc/2e/PMC9316585.tar.gz | [] | Figure2 Representative images showing the main steps in video-assisted laparoscopy surgery for the resection of small, totally endophytic renal mass localized preoperatively with the microcoil. The microcoil tail (white arrow) was visualized during laparoscopy. The excised specimen after partial nephrectomy showed an intact tumour with a clear margin. Microscopic sections of the mass showed large polygonal cells with clear cytoplasm and centrally placed small nuclei, indicating renal clear cell carcinoma (haematoxylin-eosin, original magnification 200). | yes |
PMC5975524 | Figure_4 | oa_package/d5/fc/PMC5975524.tar.gz | [' 4a), or scattered in the tumor stroma in other cases (', '4b).', 'Other cases (b) showed nuclear staining of fewer cells positive for this markerClinical parameters as predictors of patient prognosisWe examined trends between age of patients at the time of diagnosis, tumor grade or tumor stage with overall survival.'] | Fig. 4 Distribution of FoxP3 expressing T regulatory cells in ovarian tumors. Intense nuclear staining of FoxP3 positive lymphocytes in a focal arrangement ( ). Other cases ( ) showed nuclear staining of fewer cells positive for this marker | yes |
PMC6544288 | Figure_2 | oa_package/43/31/PMC6544288.tar.gz | ['The region of interest (ROI) was manually drawn to include only the parenchyma of the liver or spleen as large as possible in each image with confidence mapping ().', 'g002A 53-year-old male with chronic hepatitis B infection and pathologic fibrosis stage 3.'] | 10.1371/journal.pone.0217876.g002 | yes |
PMC6919407 | Figure_1 | oa_package/8f/dc/PMC6919407.tar.gz | ['Hand X-ray: PA and lateral view.'] | Figure 1 Hand X-ray: PA and lateral view. | yes |
PMC5323104 | Figure_7 | oa_package/cb/ec/PMC5323104.tar.gz | ['8ClearImplant in situ Retina well-lookingImplant stable Photoreceptor/RPE layer intactPDMS (n = 4 pigs); PDMS-PmL (n = 6 pigs)OCT and ocular examination for monitoring long-term biostability of PDMS-PmL in the subretinal space of transplanted porcineA.'] | Figure 7 OCT and ocular examination for monitoring long-term biostability of PDMS-PmL in the subretinal space of transplanted porcine OCT screening demonstrated the well retinal attachment of PDMS-PmL in the subretinal space of transplanted pigs two years after transplantation with retinal surgery. Control: normal retinal without surgery. PDMS: transplantation of non-modified PDMS in the subretinal space of pigs. The gap between yellow and red cursors represents retinal detachment. Serial observation of funduscopic photography at 12- and 24-month showed that PDMS-PmL implants at the same anatomical position without inducing any complication after transplantation. Two years after implantation, scotopic ERG responses recorded in PDMS-PmL transplanted eyes were no significantly different from that recorded in control eyes. - The macula area of PDMS ( = 4) and PDMS-PmL ( = 6) eyes, as well as non-surgery control eyes, were isolated 2 years after transplantation, and subjected to ELISA assay for detecting PEDF levels. The mean PEDF levels were showed in the bar chart in , and the paring control left eyes with treated right eyes were showed in and Comparing to decreased levels of PEDF in PDMS eyes, PDMS-PmL eyes showed the maintenance of trophic PEDF levels. | yes |
PMC4498558 | Figure_1 | oa_package/37/2d/PMC4498558.tar.gz | [' 1).', 'FDG-PET on a May,23rd, with an Alzheimer like glucose utilization deficit in temporo-parietal regions and the posterior cingulum and b June, 25th, with a normalization of glucose utilization in all brain regionsTo further rule out Alzheimer pathology an amyloid-PET with was performed.'] | Fig. 1 FDG-PET on May,23rd, with an Alzheimer like glucose utilization deficit in temporo-parietal regions and the posterior cingulum and June, 25th, with a normalization of glucose utilization in all brain regions | yes |
PMC8321575 | Figure_6 | oa_package/56/7b/PMC8321575.tar.gz | ['Compared with controls, Endo-Hdac9KO mice showed no differences in total body weight, lipid levels, or hematological cell counts (Supplemental , A D).', 'Diastolic blood pressure differed marginally between groups in 8-week-old mice, but there was no subsequent difference between these same groups for diastolic blood pressure at 16 or 24 weeks of age (Supplemental E).', 'There was no difference between groups for systolic blood pressure at any time point (Supplemental E).', 'En face analysis of thoracic aortas demonstrated that Endo-Hdac9KO mice had a relative 25% decrease in aortic plaque area compared with control mice (A).', 'Consistent with this, oil red O staining indicated reduced plaque area in Endo-Hdac9KO mice compared with controls in both the aortic root and arch (B and Supplemental , A and B).', 'Furthermore, plaque lipid content was significantly reduced in the aortic root and ascending aorta of Endo-Hdac9KO mice compared with controls (B and Supplemental , A and B).', 'Calcification was also significantly reduced in plaques from the aortic root of Endo-Hdac9KO mice (C), although not in the ascending aorta or aortic arch (Supplemental , C and D).', 'In addition, by Masson s trichrome staining of aortic root sections, while the extent of collagen and presence of necrotic cores were similar between Endo-Hdac9KO mice and controls, there was a significant increase in fibrous cap thickness in Endo-Hdac9KO mice (D).', 'Intra-plaque hemorrhage was not different between Endo-Hdac9KO mice and controls (E and Supplemental , A and B).', 'Endothelial-specific Hdac9 knockout reduces atherosclerosis and enhances plaque stability in vivo.'] | Figure 6 Endothelial-specific knockout reduces atherosclerosis and enhances plaque stability in vivo. All comparisons shown are using Endo- mice versus littermate controls, and all mice received tamoxifen. ( ) Representative images of aorta before embedding into OCT and en face analysis of aortic plaque. ( ) Representative images of the aortic root with staining using oil red O, with quantification of total plaque area and plaque lipid content (red stained area as a percentage of total plaque area). ( ) Representative images of aortic root sections using Von Kossa stain (black represents calcification), with quantification of calcification. ( ) Representative aortic root images stained with Massons trichrome with quantification of collagen content, fibrous cap thickness, and presence/nonpresence of necrotic core (blue, collagen; pink, macrophages and cardiac muscle). ( ) Representative immunofluorescence staining images in aortic root plaques for TER119- (red, erythrocyte marker) and DAPI-stained nuclei (blue) and quantification. ( ) Representative immunofluorescence staining images of aortic root plaques for BrdU- (green), CD31- (red), and DAPI-stained nuclei (blue) in the endothelial and subendothelial layers, and quantification. Scale bars: 100 m ( ); 50 m ( and ). = 10 controls versus = 9 Endo- mice for all panels. * 0.05; ** 0.01. All analyses performed using unpaired Students test except the following, for which Mann-Whitney test was used: plaque area ( ), calcification ( ), and both analyses in . In addition, presence or nonpresence of necrotic core ( ) was analyzed using Fishers exact test. | yes |
PMC6062570 | Figure_3 | oa_package/97/79/PMC6062570.tar.gz | ['A 62-year-old female with adenocarcinoma at left upper lobe.'] | Figure 3 A 55-year-old male with mucinous adenocarcinoma at left lower lobe. ( ) CT image, ( ) T2-weighted image, ( ) ADC map of DWI with placed ROI (mean ADC value in ROI is 1.9510 mm /s), ( ) one field of view in histopathological slice for analysis (HE, magnification 400, cell density: 205, nuclear-to-cytoplasm ratio: 0.25, necrotic fraction: class I, presence of mucus: yes, low grade of differentiation). | yes |
PMC11513694 | Figure_4 | oa_package/f7/85/PMC11513694.tar.gz | ['CE-MRI: contrast-enhanced magnetic resonance imaging; FLAIR: fluid attenuation inversion recovery; T1WI: T1-weighted imaging; T2WI: T2-weighted imagingCE-MRI of the brain axial sections at the level of the ganglion-capsular region T1WI (A), T2WI (B), FLAIR (C), and T1 post-contrast (D) sequences showing variable sized, diffusely scattered round to oval lesions appearing hypointense on T1WI (orange arrows), hyperintense on T2WI/FLAIR (blue arrows) with post-contrast ring enhancement (yellow arrows) suggesting tuberculomas.'] | Figure 4 CE-MRI of the brain axial sections at the level of the ganglion-capsular region T1WI (A), T2WI (B), FLAIR (C), and T1 post-contrast (D) sequences showing variable sized, diffusely scattered round to oval lesions appearing hypointense on T1WI (orange arrows), hyperintense on T2WI/FLAIR (blue arrows) with post-contrast ring enhancement (yellow arrows) suggesting tuberculomas. CE-MRI: contrast-enhanced magnetic resonance imaging; FLAIR: fluid attenuation inversion recovery; T1WI: T1-weighted imaging; T2WI: T2-weighted imaging | yes |
PMC10671061 | Figure_1 | oa_package/bd/c7/PMC10671061.tar.gz | ['0001; see ).', 'Higher levels of antimicrobial hBD-1, hBD-2 and chemokines CXCL-1/2 and CXCL-8 were detected on patients psoriatic lesions when compared to the non-lesional skin of the same patients, whereas the levels of proinflammatory IL-1 were higher on non-lesional patients ().', 'Lawrence Erlbaum AssociatesHillsdale, NJ, USA1988Skin surface average biomarker concentration measured at baseline with Transdermal Analysis Patches on lesional and non-lesional skin of psoriasis patients (N = 37).'] | Figure 1 Skin surface average biomarker concentration measured at baseline with Transdermal Analysis Patches on lesional and non-lesional skin of psoriasis patients (N = 37). The average biomarker concentrations of hBD-1, hBD-2, IL-1, CXCL-1/2, and CXCL-8 detected from non-lesional skin (white bars) and lesional skin (dark grey bars) have been blotted. -axis: Average concentration of analyzed biomarker at baseline on the skin surface in ng/mL. -axis: sampled biomarker. Error bars on graphs present the 95% confidence intervals for the average of combined measurements in the participants. A statistically significant difference (paired sample -test) between biomarker expression on lesional and non-lesional skin is shown with asterisks: * < 0.05, **** < 0.0001). NDnot detected. | yes |
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