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cc-by | Sleep apnoea is associated with significant daytime functioning impairment and marked cardiovascular morbidities, leading to a significant increase in mortality. Sympathetic activation, oxidative stress and systemic inflammation have been shown to be the main intermediary mechanisms associated with sleep apnoea and int... | 10.1183/09059180.00004513 | review | en | 2,013 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Sleep apnoea is associated with significant daytime functioning impairment and marked cardiovascular morbidities, leading to a significant increase in mortality. Sympathetic activation, oxidative stress and systemic inflammation have been shown to be the main intermediary mechanisms associated with sleep apnoea and int... | 10.1183/09059180.00004513 | review | en | 2,013 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Epidemiological aspects From OSA to HF Cross-sectional data from the Sleep Heart Health study in 4442 patients (mean age 62 years, males 44%) demonstrated that the adjusted risk of prevalent self-reported heart failure in patients with OSA (AHI. 10) was almost 2. 4 times higher compared to patients with AHI f10 [118].... | 10.1183/09059180.00004513 | review | en | 2,013 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Those with at least moderate sleep apnoea received either CPAP or ASV and were observed for 4 years. The primary end-point was the event-free survival time to first appropriate cardioverter-defibrillator therapy. Both CSA and OSA were independently associated with a shorter eventfree survival time period, awaiting firs... | 10.1183/09059180.00004513 | review | en | 2,013 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Ongoing studies using assisted servo-ventilation will elucidate the exact benefit that might be expected in terms of survival [167]. Also, aiming to reduce the severity of CSA with different treatments of heart failure is promising but not definitive. Among heart failure treatments, resynchronisation therapy reduced t... | 10.1183/09059180.00004513 | review | en | 2,013 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | , 2002; Fedak, 2004]. While their principle intent was to improve understanding of seal foraging strategies [Biuw et al. , 2007; Fedak, 2013] , they have also provided as a by-product a viable and cost-effective method of sampling hydrographic properties in many regions of the Southern Ocean [Charrassin et al. , 2008... | 10.1002/2013gl058304 | article | en | 2,013 | true | false | false | false | Earth and Planetary Sciences | https://openalex.org/fields/19 |
cc-by | The MEOP-CTD Database [5] The MEOP-CTD database includes 349 CTD-SRDLs, representing 165,000 TS profiles (see Figure 1 and Table S1 in the supporting information). The majority of loggers were deployed on elephant seals, with a lesser number on Weddell and crabeater seals. On average, profiles are 500 m deep, altho... | 10.1002/2013gl058304 | article | en | 2,013 | true | false | false | false | Earth and Planetary Sciences | https://openalex.org/fields/19 |
cc-by | The ECCO model grid is global, with an approximate 1°× 1°horizontal resolution and 50 vertical levels [Forget, 2010]. [11] Two 1. 5 year long state estimates were carried out for the period 2007 to mid-2008. The reference state estimate (here denoted as REF) was constrained with Argo profiles only (166,000 T + S profi... | 10.1002/2013gl058304 | article | en | 2,013 | true | false | false | false | Earth and Planetary Sciences | https://openalex.org/fields/19 |
cc-by | Nevertheless, improvements already seen in the crucial region of sea ice formation are expected to be of growing importance as more seal data become available. [19] The MEOP-CTD database is constantly expanding, as more CTD-SRDLs are being deployed every year. New sites of deployments are being used, or will be soon, s... | 10.1002/2013gl058304 | article | en | 2,013 | true | false | false | false | Earth and Planetary Sciences | https://openalex.org/fields/19 |
cc-by | As a case study to demonstrate the effect of ADC catabolism on ADC toxicity, Dr Schutten presented results showing increase in toxicity of trastuzumab-mc-vc-PAB-MMAF ADC by increasing the DAR. She also presented data from Junutula et al. 16 comparing THIOMAB-drug conjugates (TDC) with ADC, where it was shown that TDC ... | 10.4161/mabs.27437 | article | en | 2,013 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | It was observed that the LGR5-targeting ADC resulted in an on-target (intestinal stem cell-targeted) toxicity, leading to blunted or fused villi. She also presented data from CD22-targeting ADCs, where target-dependent depletion of replicating B cells by anti-CD22-vcMMAE ADC was observed in the monkeys. Using anti-CD22... | 10.4161/mabs.27437 | article | en | 2,013 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | October 16, 2013: ADC Development Approaches In this session, Jan Pinkas (ImmunoGen) gave a talk on advancing preclinical development of ADCs, and Dave Colcher (City of Hope) discussed use of radiolabeled antibodies and antibody constructs for preclinical and clinical Applications. Paul Parren (Genmab) then presented a... | 10.4161/mabs.27437 | article | en | 2,013 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | He showed detailed data on the effect of aldehyde tags on physical properties of proteins. The data indicated that aldehyde tags can be placed on a broad region of mAb with minimum/no effects on aggregation, antigen binding, internalization, melting temp, and FcRN binding. He then discussed the advantages of using the ... | 10.4161/mabs.27437 | article | en | 2,013 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Acknowledgements. The authors are grateful to Sergio Vicente-Serrano for providing the software used for the calculation of the Standardized Precipitation Evaporation Index and for his helpful comments on the first draft of this article. Thanks are also due to the AMAZALERT FP7 project for supporting this study, as... | 10.5194/hess-17-4885-2013 | article | en | 2,013 | false | false | true | false | Environmental Science | https://openalex.org/fields/23 |
cc-by | Acknowledgments We are grateful to Ben Allanach , Thomas Hahn , Sven Heinemeyer , Sabine Kraml , and Michael Spira for useful discussions and correspondence. FM would like to thank Alexandre Arbey and Marco Battaglia for useful discussions and comments on the manuscript. UH would like to thank Babis Anastasi... | 10.1007/jhep01(2013)061 | article | en | 2,013 | false | false | true | false | Physics and Astronomy | https://openalex.org/fields/31 |
cc-by | Acknowledgments We are grateful to Ben Allanach , Thomas Hahn , Sven Heinemeyer , Sabine Kraml , and Michael Spira for useful discussions and correspondence. FM would like to thank Alexandre Arbey and Marco Battaglia for useful discussions and comments on the manuscript. UH would like to thank Babis Anastasi... | 10.1007/jhep01(2013)061 | article | en | 2,013 | false | false | true | false | Physics and Astronomy | https://openalex.org/fields/31 |
cc-by | Data analysis. From the two individual calibrated eyes position signals we derived the disconjugate signal (left eye -right eye). The eye velocity of either conjugate (saccades) or disconjugate (vergence) signal was computed using a symmetrical twopoint differentiator after low-pass filtering with a Gaussian FIR filter... | 10.1371/journal.pone.0066652 | article | en | 2,013 | true | false | false | false | Neuroscience | https://openalex.org/fields/28 |
cc-by | Data analysis. We evaluated the Quotient of Romberg (QR) as the ratio of values in the conditions eyes open fixating at 150 cm versus eyes closed; the QR was estimated for each of the parameters listed above. Then we performed a non-parametric analysis U Mann Whitney Test for each postural parameter, comparing the QR o... | 10.1371/journal.pone.0066652 | article | en | 2,013 | true | false | false | false | Neuroscience | https://openalex.org/fields/28 |
cc-by | Acknowledgments This work is supported by the DFG Transregional Collaborative Research Centre TRR 33 and the DFG cluster of excellence "Origin and Structure of the Universe". We would like to thank each others home institutions for hospitality. | 10.1007/jhep09(2013)080 | article | en | 2,013 | false | false | true | false | Physics and Astronomy | https://openalex.org/fields/31 |
cc-by | The computed ionic balances were below 5%. The SLRS-5 external standard was used for the analyses of elemental concentrations in water. Strontium concentrations were determined using ICP-mass spectrometry with a precision of ± 2% based on an In internal standard of 20 lg/L. The chemical separation of Sr was performed i... | 10.1016/j.apgeochem.2013.07.006 | article | en | 2,013 | true | false | false | false | Earth and Planetary Sciences | https://openalex.org/fields/19 |
cc-by | After approximately 100 h of contact with a LKU bulk limestone, the Sr concentration in recharge water increased (Table 4 ) and the 87 Sr/ 86 Sr ratio approached a value of 0. 707813 (Fig. 6a and b ). Both results of batch experiments and observed data for groundwater with rapid recharge are reported for comparison o... | 10.1016/j.apgeochem.2013.07.006 | article | en | 2,013 | true | false | false | false | Earth and Planetary Sciences | https://openalex.org/fields/19 |
cc-by | Furthermore, contamination leads to Ca (and NO 3 ) excesses. The greater analytical capability of 36 Cl measurements has greatly improved the potential of this isotopic tracer to identify mixing processes. The Sr and Cl data (ionic and isotopic abundances) allow calculating the mixing ratios of deep saline water by con... | 10.1016/j.apgeochem.2013.07.006 | article | en | 2,013 | true | false | false | false | Earth and Planetary Sciences | https://openalex.org/fields/19 |
cc-by | Acknowledgements M. Kaskha is a recipient of a doctoral scholarship that was funded by the University of Tichrine. In addition, this study was funded by the University of Nîmes within the framework of its research program '' Transdisciplinary approach of environmental risks '', which was partially supported by th... | 10.1016/j.apgeochem.2013.07.006 | article | en | 2,013 | false | false | true | false | Earth and Planetary Sciences | https://openalex.org/fields/19 |
cc-by | Acknowledgments This work was supported by a scholarship from the French Government and by the Croatian Science Foundation. This support is gratefully acknowledged. | 10.3390/ma6093764 | article | en | 2,013 | false | false | true | false | Materials Science | https://openalex.org/fields/25 |
cc-by | As the pH of a protein deviates from neutral conditions, the structure of the protein changes. Thus, the functional activity of the protein can drastically decrease [46]. PFM imaging was performed directly after drying the sample. The measurement was repeated on a second transparent membrane, which confirmed the incre... | 10.1002/jbm.b.33006 | article | en | 2,013 | true | false | false | false | Materials Science | https://openalex.org/fields/25 |
cc-by | Acknowledgements This publication has emanated from research conducted with the financial support of Science Foundation Ireland under grant number SFI10/RFP/MTR2855 and was further facilitated by SFI13/CW/B2538. The authors gratefully acknowledge insightful discussions with A. Fertala , and COST action MP0904 for... | 10.1002/jbm.b.33006 | article | en | 2,013 | false | false | true | false | Materials Science | https://openalex.org/fields/25 |
cc-by | D. Guifi-Community-Distro and cloud services The cloud infrastructure service of the Community-Lab management software (see Section II-C) provides users with a set of virtual machines. The Guifi-Community-Distro is the operating system image that we have prepared to be placed on each virtual machines. The Guifi-Communi... | 10.1109/giis.2013.6684361 | article | en | 2,013 | false | true | false | false | Computer Science | https://openalex.org/fields/17 |
cc-by | ACKNOWLEDGMENT This work was supported by the European Community Framework Programme 7 FIRE Initiative projects CLOM-MUNITY , FP7-317879 , and Community Networks Testbed for the Future Internet (CONFINE) , FP7-288535. Support is also provided by the Universitat Politcnica de Catalunya BarcelonaTECH and the Spa... | 10.1109/giis.2013.6684361 | article | en | 2,013 | false | false | true | false | Computer Science | https://openalex.org/fields/17 |
cc-by | Acknowledgements We would like to thank U. Danielsson , A. Tomasiello , D. Tsimpis , T. Wrase and A. Zaffaroni for useful discussions. TVR is supported by a Pegasus Marie Curie fellowship of the FWO. MP would like to thank the Theory Group at Imperial College for the kind hospitality during the final part of... | 10.1007/jhep11(2013)010 | article | en | 2,013 | false | false | true | false | Physics and Astronomy | https://openalex.org/fields/31 |
cc-by | Acknowledgements We thank the following colleagues for facilitating access to fossil collections under their care: B. Simpson ( FMNH ), A. Kramarz ( MACN ), M. Reguero and S. Bargo ( MLP ), C. Argot , C. de Muizon , and P. Tassy ( MNHN ), and N. Valencia ( MUSM ). Special thanks to D. Brandoni ( CICYTTP... | 10.1080/14772019.2012.743488 | article | en | 2,013 | false | false | true | false | Earth and Planetary Sciences | https://openalex.org/fields/19 |
cc-by | A search for a Higgs boson decaying into a Z boson and a photon is described. The analysis is performed using proton-proton collision datasets recorded by the CMS detector at the LHC. Events were collected at center-of-mass energies of 7 TeV and 8 TeV, corresponding to integrated luminosities of 5. 0 fb -1 and 19. 6 fb... | 10.1016/j.physletb.2013.09.057 | article | en | 2,013 | true | false | false | false | Physics and Astronomy | https://openalex.org/fields/31 |
cc-by | Summary A search has been performed for a Higgs boson decaying into a Z boson and a photon. The analysis used a dataset from proton-proton collisions at a center-of-mass energy of 7 and 8 TeV, corresponding to an integrated luminosity of 5. 0 and 19. 6 fb -1 , respectively. No excess above standard model predictions ha... | 10.1016/j.physletb.2013.09.057 | article | en | 2,013 | true | false | false | false | Physics and Astronomy | https://openalex.org/fields/31 |
cc-by | ACKNOWLEDGMENTS We are grateful to N. Rebola , M. Helmstaedter , S. Silva , and members of our teams for their helpful comments. The following funding sources are acknowledged: INSERM, Max-Planck-Society, Region of Aquitaine, Erasmus-Mundus/ENC Network and DFG SFB 870. | 10.3389/fncir.2013.00002 | review | en | 2,013 | false | false | true | false | Immunology and Microbiology | https://openalex.org/fields/24 |
cc-by | RNA isolation and microarray procedures Tissues were frozen immediately in liquid nitrogen and disrupted using a mortar and pestle. Samples were homogenized in lysis buffer using a syringe and needle. Total RNA was prepared using the RNeasy ® Mini kit (Qiagen, Valencia, CA, United States). The integrity of the RNA was ... | 10.3748/wjg.v19.i21.3249 | article | en | 2,013 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | 174 10. 487 AK025181 Intestine-specific homeobox ISX 3. 968 10. 487 AB007899 Neural precursor cell expressed, developmentally down-regulated 4-like NEDD4L 8. 2 10. 487 NM_001873 Carboxypeptidase E CPE 4. 845 10. 487 NM_014479 ADAM-like, decysin 1 ADAMDEC1 2. 56 10. 487 BF195709 Calpain 5 CAPN5 2. 601 10. 487 NM_014456 ... | 10.3748/wjg.v19.i21.3249 | article | en | 2,013 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | The production of electroweak bosons (photons, W and Z particles) in PbPb collisions at a centreof-mass energy per nucleon pair of 2. 76 TeV has been measured with the CMS detector at the LHC. Direct photons are selected by applying isolation criteria, while W and Z bosons are reconstructed through their muonic decay. ... | 10.1016/j.nuclphysa.2013.01.065 | article | en | 2,013 | true | false | false | false | Physics and Astronomy | https://openalex.org/fields/31 |
cc-by | Acknowledgement The author presenting these results received funding from the European Research Council under the FP7 Grant Agreement no. 259612. | 10.1016/j.nuclphysa.2013.01.065 | article | en | 2,013 | false | false | true | false | Physics and Astronomy | https://openalex.org/fields/31 |
cc-by | The amount of fine particulate organic matter (FPOM; 1000 to 0. 45 mm in size) was expressed as preserved volume (mL) after decantation in graduated test-tubes [12]. Finally, percentages of total incident radiation (IR) above the bromeliads were calculated using hemispherical photographs and an image processing softwa... | 10.1371/journal.pone.0071735 | article | en | 2,013 | false | true | false | false | Agricultural and Biological Sciences | https://openalex.org/fields/11 |
cc-by | The samples were preserved in the field in 4% (final concentration) formalin. Invertebrates were sorted in the laboratory and preserved in 70% ethanol. They were identified to genus, species or morphospecies and enumerated (species lists in [21, 24] ). Species abundance data (individuals per plant) were used to calcul... | 10.1371/journal.pone.0071735 | article | en | 2,013 | true | false | false | false | Agricultural and Biological Sciences | https://openalex.org/fields/11 |
cc-by | In the literature, two measures of the connectance are widely used: connectance and normalized connectance. Both refer to the proportion of all possible interactions that are realized, but normalized connectance is rather used for food webs comprising less than 20 species [1]. However, in this study, the two measures ... | 10.1371/journal.pone.0071735 | article | en | 2,013 | false | true | false | false | Agricultural and Biological Sciences | https://openalex.org/fields/11 |
cc-by | Then, for a selected random factor (the remaining random effects being dropped from the model), the relationship between dependent and independent variables were explored using a stepwise backwards removal procedure and only the final models containing significant variables were presented. Departures from homoscedastic... | 10.1371/journal.pone.0071735 | article | en | 2,013 | false | true | false | false | Agricultural and Biological Sciences | https://openalex.org/fields/11 |
cc-by | Acknowledgments We are grateful to the members of the Laboratoire Environnement de Petit Saut (HYDRECO) and to the members of the Nouragues Research Station for technical support and the use of their facilities. The English text was proofread by Andrea Yockey-Dejean and Kurtis Trzcinski. Two anonymous reviewers ... | 10.1371/journal.pone.0071735 | article | en | 2,013 | false | false | true | false | Agricultural and Biological Sciences | https://openalex.org/fields/11 |
cc-by | Financial support for this study was provided by the Programme Amazonie II of the French Centre National de la Recherche Scientifique (Project 2ID ), and the Programme Convergence 2007-2013 (Region Guyane ) from the European Community (Project DEGA ). This work has benefited from an '' Investissement d'Avenir ... | 10.1371/journal.pone.0071735 | article | en | 2,013 | false | false | true | false | Agricultural and Biological Sciences | https://openalex.org/fields/11 |
cc-by | 7µm PAH emission ratios, ≥ 0. 04, indicating excitation above that expected from UV heating (Ogle et al. 2010). In this paper we focus on the excited H 2 properties of a sample of 74 HCG galaxies, in particular those that show H 2 -enhancement as defined for a MOHEG. A subsequent paper will focus on the cold molecular... | 10.1088/0004-637x/765/2/93 | article | en | 2,013 | true | false | false | false | Physics and Astronomy | https://openalex.org/fields/31 |
cc-by | Spectra were extracted for all but 4 galaxies in the sample (HCG 6A, 6C, 6D and 79C) where no signal above the noise was detected. Spectra were converted to flux densities (mJy) using the extraction areas, and SL scaled to LL to match continuum levels in cases that required it (see Table 8 ). This accounts for beam re... | 10.1088/0004-637x/765/2/93 | article | en | 2,013 | false | true | false | false | Physics and Astronomy | https://openalex.org/fields/31 |
cc-by | Spitzer IRAC and MIPS Photometry The Spitzer IRAC (Fazio et al. 2004 ) and MIPS (Rieke et al. 2004 ) instruments were used to obtain imaging at 3. 6, 4. 5, 5. 8 and 8. 0µm, and 24µm, respectively, of our sample and observed as part of PID 50764 (P. I. Appleton), PID 40459 (P. I. Le Floc'h), PID 631 (P. I. Mazzarella)... | 10.1088/0004-637x/765/2/93 | article | en | 2,013 | true | false | false | false | Physics and Astronomy | https://openalex.org/fields/31 |
cc-by | 1 and find 5 out of 8 have detections, but all with relatively low luminosities. The highest Xray luminosity system is HCG 82 with a luminosity of 1. 9×10 42 erg s -1 , whereas the typical luminosity is closer to ∼ 10 41 erg s -1 ). To investigate X-ray heating within the galaxies themselves, we use archival Chandra an... | 10.1088/0004-637x/765/2/93 | article | en | 2,013 | true | false | false | false | Physics and Astronomy | https://openalex.org/fields/31 |
cc-by | X-ray Emission within Group Members Several galaxies appear to have nuclear enhancements in their X-ray data. Searching the archives for suitable coverage of the HCG MOHEGs, we have determined that HCG 6B, 25B, 82B and 95C have not been covered by Chandra/XMM and were not detected by ROSAT. All other available measurem... | 10.1088/0004-637x/765/2/93 | article | en | 2,013 | true | false | false | false | Physics and Astronomy | https://openalex.org/fields/31 |
cc-by | LVM is funded by Grant AYA2008-06181-C02 and AYA2011-30491-C02-01 , co-financed by MICINN and FEDER funds, and the Junta de Andaluca (Spain) grants P08-FQM-4205 and TIC-114. This research has made use of the NASA/IPAC Extragalactic Database (NED) which is operated by the Jet Propulsion Laboratory, Californ... | 10.1088/0004-637x/765/2/93 | article | en | 2,013 | true | false | false | false | Physics and Astronomy | https://openalex.org/fields/31 |
cc-by | Initial analyses of such individuals suggested that all or most phenotypic manifestations of DS were due to a short critical region (McCormick et al. 1989; Rahmani et al. 1989 ), but more recent analysis refutes this and suggests that loci determining the DS phenotype are scattered across HSA21 (Lyle et al. 2004; Kor... | 10.1007/s00335-013-9475-x | article | en | 2,013 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Acknowledgments M. Bhutta was funded by a Wellcome Trust Clinical Research Fellowship. Y. E. Yu was supported by the NIH ( R01HL091519 and R01NS066072 ). We thank Frances Wiseman ( UCL Institute of Neurology ) for the gift of Ts65Dn tissue. We thank the pathology and histology teams at MRC Harwell for produc... | 10.1007/s00335-013-9475-x | article | en | 2,013 | false | false | true | false | Medicine | https://openalex.org/fields/27 |
cc-by | The tomato mutant collection used was an EMS mutant population generated in the miniature cultivar Micro-Tom by our group (Rothan and Causse, 2007; Just et al. , 2013). The collection comprises approximately 3,500 highly mutagenized mutant families thoroughly phenotyped (12 plants per M2 families) for approximately 15... | 10.1104/pp.113.232645 | article | en | 2,013 | true | false | false | false | Agricultural and Biological Sciences | https://openalex.org/fields/11 |
cc-by | We next screened the chromosomal region of interest for candidate genes with known implication in cutin synthesis or regulation. Among these were genes identified as specifically expressed in the outer epidermis of tomato by laser microdissection of various tomato pericarp tissues followed by RNA sequencing analysis (... | 10.1104/pp.113.232645 | article | en | 2,013 | true | false | false | false | Agricultural and Biological Sciences | https://openalex.org/fields/11 |
cc-by | , 2012; Yeats et al. , 2012b). The current locus name of Solyc11g006250 (1,004,368 to 1,006,899 nucleotides on chromosome 11) in the Solanaceae SGN database is GDSL2, whereas its given names were previously SlGDSL1 (Girard et al. , 2012) and cutin synthase CD1 (Yeats et al. , 2012b). In agreement with SGN, the gene ... | 10.1104/pp.113.232645 | article | en | 2,013 | true | false | false | false | Agricultural and Biological Sciences | https://openalex.org/fields/11 |
cc-by | Because strong cuticle alterations are detrimental to fruit quality, we preferred to focus in a first step on the phenotypic alterations responsible only for variations in fruit brightness (glossy or dull fruits), which likely arise from more subtle changes in cuticle properties. Pleiotropic mutations were also exclude... | 10.1104/pp.113.232645 | article | en | 2,013 | true | false | false | false | Agricultural and Biological Sciences | https://openalex.org/fields/11 |
cc-by | ACKNOWLEDGMENTS The authors thank Michel Hernould for fruit cytology analyses, Aurélie Petit for her help in statistical analyses, Isabelle Atienza for taking care of the plants in the greenhouse, and Isabelle Svahn for her participation. The ESEM experiments were performed at the Electronic Imaging pole of th... | 10.1104/pp.113.232645 | article | en | 2,013 | false | false | true | false | Agricultural and Biological Sciences | https://openalex.org/fields/11 |
cc-by | Array-CGH experiments were performed with the maximum amount of DNA available. Array-CGH analysis was performed according to the Agilent protocol with minor protocol modifications: DNA was labeled by direct incorporation of Cya-5 and Cya-3 using a CGH labeling kit for Oligo-array (Enzo Life Sciences, COVALAB, France) f... | 10.1371/journal.pone.0059956 | article | en | 2,013 | true | true | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Specificity: The five samples with normal karyotypes showed that the smaller the amount of DNA, the greater the DLRS (between 0. 26 and 0. 60). Detection of CNV showed an average of three per patient ranging from 400 bp to 600 kb; all were found in the Database of Genomic Variants (DGV). Twelve samples. 16 weeks of ges... | 10.1371/journal.pone.0059956 | article | en | 2,013 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | In prenatal diagnosis, the detection of new CNV not reported in the Database of Genomic Variants (DGV), or variants with incomplete penetrance without ultrasound abnormalities could lead to major difficulties in genetic counseling. In conclusion, this study describes a reproducible method for DNA extraction from only 1... | 10.1371/journal.pone.0059956 | article | en | 2,013 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | EXPERIMENTAL PROCEDURES Identification of PDZ Domain Sequences in the Human Genome-Domain boundaries were obtained by cross-searching Interpro (V18), PFAM (V23), and SMART version 5. 0 (30). Each domain was extended on each side with a 10-amino-acid tail from the original protein to account for variations in border pr... | 10.1074/mcp.o112.021022 | article | en | 2,013 | false | true | false | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | 1 software (Bruker Daltonics, Inc. ). Protein searches were done using an in-house Mascot search engine (MatrixScience Ltd. , London, UK) against the SwissProt database 2012_02 version, using "human" for taxonomy (20,247 sequences). Mascot search results from E6 and Vangl2 pull-down on Caco-2 and/or HEK 293T cell lysat... | 10.1074/mcp.o112.021022 | article | en | 2,013 | true | false | false | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | 1% Triton X-100 for 5 min, and blocked with 10% fetal calf serum in PBS for 30 min before the addition of antibodies as described elsewhere (37). Images were acquired using a Zeiss Axiovert 200mot microscope linked to a Meta LSM 510 confocal module operated by LSM-FCS software (Carl Zeiss MicroImaging Inc. , Jena, Ger... | 10.1074/mcp.o112.021022 | article | en | 2,013 | false | true | false | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | RESULTS Building a Human PDZome Array-We have set up a rational approach to test the potential interactions of a given protein against an array of almost all human PDZ domains. This approach, based on a single Y2H assay, has been shown to be effective in probing the entire set of C. elegans PDZ domains for interacting ... | 10.1074/mcp.o112.021022 | article | en | 2,013 | true | false | false | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | Out of 17 PDZ proteins co-purified with the E6 peptide, 11 were also identified as direct E6 interactors by the PDZome Y2H array, among which CASK and SNX27 are newly identified E6 interactors. The results and the overlap between Y2H and biochemical approaches are presented in Fig. 1C. To test our interaction dataset f... | 10.1074/mcp.o112.021022 | article | en | 2,013 | true | false | false | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | 1 KIAA0488 SYJ2B_HUMAN 1 P57105 NP_060843. 2 SYNJ2B, OMP25 TAX1BP3_HUMAN 1 O14907 NP_055419. 1 Tax-1, TIP1 Yes 3 USHBP1_HUMAN 3 (2) Q8N6Y0 AAH16057. 1 AIEBP, MCC2, USH1C confirmed by in vitro binding assays using HTRF or ELISA (17 out of 25) and that the testing PDZ array is robust enough to limit the false positive ra... | 10.1074/mcp.o112.021022 | article | en | 2,013 | true | false | false | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | 7A ). When endogenous SNX27 function was inhibited through injection of an MO, neural tube closure was strongly impaired in a dose-dependent manner (Figs. 7B and 7C ). This phenotype is typical of defective PCP signaling (71). Furthermore, co-injection of sub-optimal amounts of SNX27 and Vangl2 MOs yielded stronger n... | 10.1074/mcp.o112.021022 | article | en | 2,013 | true | false | false | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | Acknowledgments-We thank Samuel Granjeaud for his contribution to the improvement of mass spectrometry data analysis. | 10.1074/mcp.o112.021022 | article | en | 2,013 | false | false | true | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | LIN7C_HUMAN 21935 Yes No No 60 No No 56 No 56 * This work was supported by grants from Association pour la Recherche contre le Cancer (fellowship to E. B. and " Projet ARC" program to MS) and La Ligue Contre le Cancer ( Label Ligue (J. P. B. ) and Ligue fellowship to A. M. D. ), EUCAAD ( FP7 program ), INC... | 10.1074/mcp.o112.021022 | article | en | 2,013 | false | false | true | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | Defining the model space is an important exercise as it characterizes what is possible geologically given the modelling method, geodiversity metrics and input data set. Knowledge of the model space parameters assists definition of geological possibility, given the input data set, method of model calculation and geodive... | 10.1093/gji/ggt311 | article | en | 2,013 | true | true | false | false | Earth and Planetary Sciences | https://openalex.org/fields/19 |
cc-by | Acknowledgements We wish to thank Itai Benjamini for suggesting the problem to us. This paper was written during the visit of the first two authors to the Weizmann Institute in Israel. The first author was supported by the EU Marie-Curie RTN CODY , the ERC AG CONFRA , as well as by the Swiss FNS and the Weizmann ... | 10.1214/ecp.v18-2862 | article | en | 2,013 | false | false | true | false | Mathematics | https://openalex.org/fields/26 |
cc-by | A score between 0 and 3 is given for each 10-year cluster for different items: residence location, occupation, passive UV exposure, active UV exposure, and photo-protection habits. The value from 0 (none) to 3 (very) is given by considering the importance of UV exposure for the considered item. SBSH is the sum of score... | 10.2147/ccid.s44686 | article | en | 2,013 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Evaluation was carried out on pictures resized and reframed according to a standard operational procedure with editing software (Photoshop ® , version 10; Adobe Systems Incorporated, New York, NY, USA) to ensure that only the scored facial area was displayed on the screen. Pictures are presented to each expert in rando... | 10.2147/ccid.s44686 | article | en | 2,013 | false | true | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | To this end, for each zone, one predictor domain from the five-domain ensemble has to be selected such that contiguous areas with the same predictor domain are formed. The smooth distribution of the domain centre locations together with their rather small range should facilitate this. The domain size has a higher spati... | 10.5194/hess-17-4189-2013 | article | en | 2,013 | true | false | false | false | Environmental Science | https://openalex.org/fields/23 |
cc-by | Destructive measurements of leaf dimensions Groups of 62, 17, and 18 plants were selected at random from the 2007-Sp, 2010-LD, and 2010-HD crops, respectively, and destructively sampled at various times (5-11 times, according to the crop), beginning when the basal leaves were expanding and ending when all the leaves we... | 10.3389/fpls.2013.00418 | article | en | 2,013 | true | false | false | false | Agricultural and Biological Sciences | https://openalex.org/fields/11 |
cc-by | Modeling time of the inflexion point of the expansion function The time t 0 p, k (i) of the inflexion point of the time course function of the organ k (lea for terminal leaflet, int for internode) at relative rank i of plant p was estimated from observed data as described in Fitting of Organ Expansion. We also aimed to... | 10.3389/fpls.2013.00418 | article | en | 2,013 | true | false | false | false | Agricultural and Biological Sciences | https://openalex.org/fields/11 |
cc-by | RESULTS We will first present the variability present in the datasets used for expansion studies. We will then propose a simplified representation of rose compound leaves for studies of the kinetics of expansion, and describe the principal features of organ expansion kinetics: global pattern, origin and amplitude of th... | 10.3389/fpls.2013.00418 | article | en | 2,013 | true | false | false | false | Agricultural and Biological Sciences | https://openalex.org/fields/11 |
cc-by | ACKNOWLEDGMENTS We would like to thank P. Favre ( UMR IRHS ) for helpful suggestions concerning the protocols and data management, O. Douillet , S. Delépine , and J. Pineau ( UMR IRHS ) for experimental measurements, G. Guillemain and G. Sintès ( UMR IRHS ) for maintaining growth conditions, M. Laffaire and... | 10.3389/fpls.2013.00418 | article | en | 2,013 | false | false | true | false | Agricultural and Biological Sciences | https://openalex.org/fields/11 |
cc-by | armigera COI haplotype, present in all sampled regions in India (10 sites), Africa (2 sites), Australia (3 sites), China (1 site), and Pakistan (1 site) [25]. Two specimens were identified as Spodoptera frugiperda (KF150294, KF150295) matching HQ177352. 1 for this species (e-value: 0. 0; 99% identity (463/467)), and t... | 10.1371/journal.pone.0080134 | article | en | 2,013 | true | false | false | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | The availability of a global mtDNA COI and Cyt b haplotype database ( [25, 33] ; Table S1 ) and extensive sampling and EPIC population genetic study of H. armigera from the Old World [34] enable us to explore the possible origins from which the founding individuals originated from. However, we have been unable to d... | 10.1371/journal.pone.0080134 | article | en | 2,013 | true | false | false | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | Acknowledgments The authors greatly appreciate the support of growers who permit access to crops to collect material used in our research. Expert technical assistance was provided by Bruno B. Batista and Danielle Souza. Owain Edwards , Karl Gordon and John Oakeshott (CSIRO), and Derek Russell ( University of M... | 10.1371/journal.pone.0080134 | article | en | 2,013 | false | false | true | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | The notion of left truncation is also referred to in the literature as "zero time shift bias" or "lead time bias" or "immortality time bias". More technical details on statistical and computational issues are also outlined in the Appendix S1. All computations related to the multi-state modelling approach were done usin... | 10.1371/journal.pone.0074368 | article | en | 2,013 | false | true | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Data Sources All outcome data were obtained from prospectively collected databases. | 10.1371/journal.pone.0074368 | article | en | 2,013 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Non-transplant cohort Data from non-transplanted MDS patients with RAEB or RAEB-t were derived from the Düsseldorf registry. Only patients aged 55-69 years at diagnosis were selected. Patients who received transplantation were excluded. 137 patients were eligible for the analysis. Supportive care consisted of blood tra... | 10.1371/journal.pone.0074368 | article | en | 2,013 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Transplant cohort The transplanted patients were obtained from the EBMT database. 247 patients (male: n = 169, female: n = 78) were eligible for analysis. Disease status at diagnosis was RAEB (n = 173) and RAEB-t (n = 74). At time of transplantation diagnosis was RAEB (n = 135), RAEB-t (n = 83) and transformed secondar... | 10.1371/journal.pone.0074368 | article | en | 2,013 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | As a Working Party of the EBMT (CLWP), we were allowed to use the data for this study. The non-transplant cohort gave consent to Ulrich Germing (coauthor) for using their data for scientific purposes. All data were analyzed anonymously. For details see table 1. | 10.1371/journal.pone.0074368 | article | en | 2,013 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Comparison of treatment modalities Applying the multi-state method, the overall (average) hazard ratio of the transplant group versus best supportive care, assuming proportional hazards, is estimated as 1. 29 (95% CI: 0. 95-1. 76; p = 0. 11). After adjustment for year of diagnosis as a continuous variable, the hazard r... | 10.1371/journal.pone.0074368 | article | en | 2,013 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | The horizontal axis measures time in years since diagnosis (on a non-linear scale). Here we see from Figure 4 that the entire detrimental effect of transplant when estimated as one average over the entire follow up time, is generated in the first year after diagnosis while thereafter the Hazard Ratio is 1 (log(HR)=0)... | 10.1371/journal.pone.0074368 | article | en | 2,013 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | This is not a matter of being right or wrong for any of these approaches: they just rely on crucial assumptions. Moreover, even with an optimal choice of statistical methodology, no valid analysis can be done without the availability of a comprehensive dataset including all variables with solid prognostic significance ... | 10.1371/journal.pone.0074368 | article | en | 2,013 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Acknowledgements We thank the centers who reported data to EBMT and Düsseldorf registry. For centers which contributes patients for this study see Appendix S2. | 10.1371/journal.pone.0074368 | article | en | 2,013 | false | false | true | false | Medicine | https://openalex.org/fields/27 |
cc-by | For precipitation, a large set of monthly homogenized time series aggregated by department to form 51 time series that sample a large portion of France, from Météo-France, is used (HPS as homogenized precipitation series, Moisselin et al. , 2002). HPS data are available from 1900 to 2000. In complement to this data-se... | 10.5194/hessd-10-11861-2013 | preprint | en | 2,013 | true | false | false | false | Environmental Science | https://openalex.org/fields/23 |
cc-by | GPCC and HPS data are not independent, as some stations used in GPCC are also used in HPS. However, the statistical treatment of raw data for the two datasets is largely different. HPS is a priori more adapted to the study of low-frequency variations because of the homogenization procedure applied. The extremely small ... | 10.5194/hessd-10-11861-2013 | preprint | en | 2,013 | true | false | false | false | Environmental Science | https://openalex.org/fields/23 |
cc-by | This consistency with direct observations (GPCC, HPS) is noteworthy as 20CR provides an indirect and totally independent estimation of precipitation. Indeed, no observed precipitation is used in 20CR. Note that SLP observations, the only variable assimilated in 20CR, are much sparser in the early period of the reanalys... | 10.5194/hessd-10-11861-2013 | preprint | en | 2,013 | true | false | false | false | Environmental Science | https://openalex.org/fields/23 |
cc-by | 2), multidecadal variability in French river flows is characterized (Sect. 3). The mechanisms behind river flows variations in spring are described in Sect. 4. Hydro-meteorological Discussion Paper | Discussion Paper | Discussion Paper |simulations are analyzed in Sect. 5 in the objective to better understand multi-dec... | 10.5194/hessd-10-11861-2013 | preprint | en | 2,013 | true | false | false | false | Environmental Science | https://openalex.org/fields/23 |
cc-by | Acknowledgements. This work was supported by the French National Research Agency (ANR) in the framework of its JCJC program ( ECHO, decision no ANR 2011 JS56 014 01 ). The authors thank Laurent Terray , Christophe Cassou and Yohan Ruprich-Robert for useful discussions about this work. The authors also ackn... | 10.5194/hessd-10-11861-2013 | preprint | en | 2,013 | true | false | true | false | Environmental Science | https://openalex.org/fields/23 |
cc-by | We present the scaling relation between Sunyaev-Zeldovich (SZ) signal and stellar mass for almost 260,000 locally brightest galaxies (LBGs) selected from the Sloan Digital Sky Survey (SDSS). These are predominantly the central galaxies of their dark matter halos. We calibrate the stellar-to-halo mass conversion using r... | 10.1051/0004-6361/201220941 | article | en | 2,013 | true | false | false | false | Physics and Astronomy | https://openalex.org/fields/31 |
cc-by | These were selected from the Sloan Digital Sky Survey (SDSS) using criteria designed to maximize the fraction of objects that are the central galaxies of their dark matter halos. We stack the Planck data in order to estimate the mean SZ signal for LBGs in a series of stellar mass bins. We then use mock galaxy catalogue... | 10.1051/0004-6361/201220941 | article | en | 2,013 | true | false | false | false | Physics and Astronomy | https://openalex.org/fields/31 |
cc-by | Two data processing centres (DPCs) check and calibrate the data and make maps of the sky (Planck HFI Core Team 2011b; Zacchei et al. 2011 ). Planck's sensitivity, angular resolution, and frequency coverage make it a powerful instrument for Galactic and extragalactic astrophysics as well as for cosmology. Early astroph... | 10.1051/0004-6361/201220941 | article | en | 2,013 | true | false | false | false | Physics and Astronomy | https://openalex.org/fields/31 |
cc-by | A Locally Brightest Galaxy Catalogue To select a sample of central galaxies, we first define a parent population with r < 17. 7 (r-band, extinction-corrected, Petrosian magnitude) from the spectroscopic galaxy catalogue of the New York University Value Added Galaxy Catalogue 2. This was built by Blanton et al. (2005) ... | 10.1051/0004-6361/201220941 | article | en | 2,013 | true | false | false | false | Physics and Astronomy | https://openalex.org/fields/31 |
cc-by | Stability of the signal in different sky surveys We have also checked that the SZ signal is stable against splitting the Planck data into complementary subsets. For instance, the signal obtained from the maps of the first 6 months of observing time is fully consistent with that obtained from maps of the second 6 months... | 10.1051/0004-6361/201220941 | article | en | 2,013 | true | false | false | false | Physics and Astronomy | https://openalex.org/fields/31 |
cc-by | This increases the apparent extent of the signal in stacked maps like Fig. 5 , but decreases the contribution to the signal through a matched filter centred on the galaxy (see Appendix C). Using our simulation of the LBG catalogue, we can account fully for these effects and extract the underlying Y 500 -M 500 relation ... | 10.1051/0004-6361/201220941 | article | en | 2,013 | true | false | false | false | Physics and Astronomy | https://openalex.org/fields/31 |
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