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cc-by | Imputation was conducted on each of eleven datasets separately, using the IMPUTE v1 software [32] and haplotype-phased HapMap Phase 2 (release 22) European CEU founders as a reference panel. Imputation of BRASS and EIRA was previously reported [28, 33] , and we followed the same imputation procedures for the remaini... | 10.1371/journal.pgen.1003394 | review | en | 2,013 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Acknowledgments We thank Lars Klareskog and Lars Alfredsson for their contribution to the EIRA cohort, and the Swedish Rheumatology Register and Biologics Register (ARTIS) for providing follow-up data for the patients in the EIRA and KI study groups. We thank participants in the Biologics in Rheumatoid Arthritis... | 10.1371/journal.pgen.1003394 | review | en | 2,013 | false | false | true | false | Medicine | https://openalex.org/fields/27 |
cc-by | $ This work was supported by AiresSud (project 7015 ), Coadvise (project FP7-PEOPLE-IRSES-2008 No. 230833 ) and Treasure (an Inria Euromed 3+3 project, http: //project. inria. fr/treasure/). This article is an extension of the IFAC 2011 proceeding [3]. | 10.1016/j.cej.2013.05.073 | article | en | 2,013 | false | false | true | false | Environmental Science | https://openalex.org/fields/23 |
cc-by | Association Studies and QTL Detection In the selective genotyping approach (survival-associated QTL), marker-trait association was inferred by testing difference in marker allele frequencies among the two population tails. The Pearson x 2 test (1 dl) was performed at every marker used for the genome scan to search for ... | 10.1371/journal.pone.0055302 | article | en | 2,013 | false | true | false | false | Immunology and Microbiology | https://openalex.org/fields/24 |
cc-by | A whole post challenge life-time dataset was built. Individual data were the surviving status (dead or alive at the end of the challenge) and the time to death (TTD, in days after infection) of each fish that died. Surviving fish corresponded to 'censored' observations, i. e. that the expected event (death) was not rec... | 10.1371/journal.pone.0055302 | article | en | 2,013 | true | true | false | false | Immunology and Microbiology | https://openalex.org/fields/24 |
cc-by | The QTL effects (% of phenotypic variance explained) were estimated by testing the within family effect of the alternative alleles at the marker closest to the QTL location (ANOVA with SAS software). QTL effect on survival was estimated using TTD, assuming a Gaussian distribution and fixing the maximum TTD at day 28 in... | 10.1371/journal.pone.0055302 | article | en | 2,013 | false | true | false | false | Immunology and Microbiology | https://openalex.org/fields/24 |
cc-by | In fact, most of the resistance to VHSV infection was explained by the same genomic region in both families. Few additional regions were also involved, but with effects more disparate and of lesser magnitude. In order to refine the estimation of the major QTL effect (RT31), an analysis including life-time data througho... | 10.1371/journal.pone.0055302 | article | en | 2,013 | true | false | false | false | Immunology and Microbiology | https://openalex.org/fields/24 |
cc-by | The Major Survival-associated QTL was Detected in Two Additional Families Results of the two DH families suggested that a common major QTL plays a pivotal role in the resistance/susceptibility to VHSV in different genetic backgrounds. To provide additional support to this result, we searched for the survival-associated... | 10.1371/journal.pone.0055302 | article | en | 2,013 | true | false | false | false | Immunology and Microbiology | https://openalex.org/fields/24 |
cc-by | For VREFT-associated QTL, 133 and 300 fish respectively were analysed in the two families. A total of 8 and 10 markers located on RT31 were genotyped in DH-F98 and DH-F00 respectively. Marker names and positions are available on supplementary Table 1S. Likelihood values were obtained using the QTLMap software. Likelih... | 10.1371/journal.pone.0055302 | article | en | 2,013 | false | true | false | false | Immunology and Microbiology | https://openalex.org/fields/24 |
cc-by | Acknowledgments Authors thank the staff of INRA experimental facilities (fish farm in Gournay-sur-Aronde, and platform of infectiology in Jouy-en-Josas) for help in fish management, Jerome GARRIGUE and Alix SAUSSET for contribution to genotyping, and Dr Carole MORENO for helpful advice in using QTLMap software. W... | 10.1371/journal.pone.0055302 | article | en | 2,013 | false | false | true | false | Immunology and Microbiology | https://openalex.org/fields/24 |
cc-by | The research leading to these results has received co-funding from European Community (IFOP) and French Ministry of Research (grant agreement DPMA/CIPA/INRA No. 2004/190 , AGENOP project) and funding from the European Community 's Seventh Framework Programme (FP7, 2007-2013), Research Infrastructures action ... | 10.1371/journal.pone.0055302 | article | en | 2,013 | false | false | true | false | Immunology and Microbiology | https://openalex.org/fields/24 |
cc-by | In 2011, we assessed data from maternity centres of Bangui and found that more than 75% of pregnant women accepted HIV testing. This finding is in accordance with the recommended threshold of acceptance [32]. Our preliminary evaluation showed a relatively high rate of HIV infection (7. 3%) among pregnant women. The pr... | 10.1186/1745-6215-14-255 | article | en | 2,013 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Data collected At baseline, the following data will be collected: sociodemographic characteristics, clinical data, obstetric history, gestational age estimated from the date of the last menstrual period and/or measured by uterine fundal height, and biological end-points (CD4 count, HIV viral load (VL), malaria diagnosi... | 10.1186/1745-6215-14-255 | article | en | 2,013 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Outcome measures The primary end-point of the trial is placental parasitaemia at delivery. Data on this variable will be coded as positive or negative results. Other outcome measures are adherence to co-trimoxazole treatment, adverse events related to co-trimoxazole and SP-IPT, the incidence of malaria episodes during ... | 10.1186/1745-6215-14-255 | article | en | 2,013 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Statistical analysis The primary end-point will be analysed as intention-totreat; deaths and women lost to follow-up will be considered failures. Analysis of the 'per protocol' population will be conducted among women who complete the study until delivery and undergo the recommended initial treatment. The data will be ... | 10.1186/1745-6215-14-255 | article | en | 2,013 | true | true | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Acknowledgements This study is funded by the Fondation de France , Project number: 00024151. Antiretroviral drugs given to women to prevent mother-to-child HIV transmission were provided by the National Programme of HIV/AIDS Control Service (Global Health Fund). The authors are grateful to the Total Group in the Ce... | 10.1186/1745-6215-14-255 | article | en | 2,013 | false | false | true | false | Medicine | https://openalex.org/fields/27 |
cc-by | The A-Train observations provide an unprecedented opportunity for the production of high quality dataset describing cloud properties. We illustrate in this study the use of one year of coincident POLDER (Polarization and Directionality of the Earth Reflectance), MODIS (MODerate Resolution Imaging Spectroradiometer) and... | 10.5194/amtd-6-8371-2013 | article | en | 2,013 | true | false | false | false | Environmental Science | https://openalex.org/fields/23 |
cc-by | (2010). A logical and reasonable decision tree is so required in processing of the final cloud phase product from different combined methods. This requires a better understanding of both strengths and weaknesses of each retrieval method. The A-Train satellites give us an unprecedented opportunity for a joint study of t... | 10.5194/amtd-6-8371-2013 | article | en | 2,013 | true | false | false | false | Environmental Science | https://openalex.org/fields/23 |
cc-by | A brief overview of the different cloud phase retrieval algorithms used for POLDER, MODIS and CALIOP and a description of associated datasets is provided in the second section. A third section is devoted to the global comparison of cloud phase products between POLDER and MODIS. Further assessment of the two datasets ob... | 10.5194/amtd-6-8371-2013 | article | en | 2,013 | true | false | false | false | Environmental Science | https://openalex.org/fields/23 |
cc-by | Dataset and algorithm descriptions Two datasets obtained from POLDER, MODIS and CALIOP and created by the ICARE data and services center are used for this study. The first one is a joint POLDER/MODIS (PM) dataset containing all Aqua/MODIS collection 5 level 2 cloud products and PARA-SOL/POLDER3 collection 2 level 2 clo... | 10.5194/amtd-6-8371-2013 | article | en | 2,013 | true | false | false | false | Environmental Science | https://openalex.org/fields/23 |
cc-by | The second dataset called CALTRACK is a subset of products from POLDER, MODIS and different other sensors or meteorological reanalysis extracted along the CALIOP curtain. The level 2 CALTRACK products contain coincident data issued from several sensors under the CALIOP tracks at 5km horizontal resolution. These coincid... | 10.5194/amtd-6-8371-2013 | article | en | 2,013 | true | false | false | false | Environmental Science | https://openalex.org/fields/23 |
cc-by | Global distribution observed from POLDER and MODIS The first part of the analysis is dedicated to a statistical and global comparison of cloud phase observed from POLDER and MODIS. From the PM dataset, each pixel observed by both instruments can be attributed one of the three phase index (ice, liquid or mixed) from POL... | 10.5194/amtd-6-8371-2013 | article | en | 2,013 | true | false | false | false | Environmental Science | https://openalex.org/fields/23 |
cc-by | In summary, CALIOP γ-δ features are very consistent with MODIS and POLDER phase products when those two agree. In cases where POLDER and MODIS have inconsistent decisions, CALIOP tends to agree with POLDER more often. This is most probably because both POLDER and CALIOP use somehow similar proxy for phase retrieval as ... | 10.5194/amtd-6-8371-2013 | article | en | 2,013 | true | false | false | false | Environmental Science | https://openalex.org/fields/23 |
cc-by | Discussion From the above analysis, we have seen that the passive and active sensors are in excellent agreement when both passive sensors agree with each other. However situations where the passive sensors disagree are more complex to understand but there is a high interest in understanding these differences as it can ... | 10.5194/amtd-6-8371-2013 | article | en | 2,013 | true | false | false | false | Environmental Science | https://openalex.org/fields/23 |
cc-by | Observation geometry One of the challenging issues when building a global dataset from satellite sensors is the need to prevent any sort of systematic bias related to observation geometries. The retrieved cloud phase corresponding to certain geometry may be impacted by the 3-D effects and/or incorrect assumption about ... | 10.5194/amtd-6-8371-2013 | article | en | 2,013 | true | false | false | false | Environmental Science | https://openalex.org/fields/23 |
cc-by | 6. The fraction of MODIS-ice and POLDER-mixed clouds reaches 10 % when cirrus OT is between 0. 6 and 1. 4. In single layered cloud systems, the fraction of MODIS-mixed and POLDER-ice clouds reaches to a maximum of 10 % when cirrus OT is about 0. 2. The fraction of MODIS-liquid and POLDER-ice clouds reaches to a maximum... | 10.5194/amtd-6-8371-2013 | article | en | 2,013 | true | false | false | false | Environmental Science | https://openalex.org/fields/23 |
cc-by | From this study we have seen that POLDER can erroneously detect broken clouds scenes and aerosols overlaying water clouds as mixed or ice phase. However it can correctly identify cloud phase in case of single layered thin cirrus, water clouds over snow and the supercooled water clouds. Compared to POLDER, MODIS detects... | 10.5194/amtd-6-8371-2013 | article | en | 2,013 | true | false | false | false | Environmental Science | https://openalex.org/fields/23 |
cc-by | As a synergistic phase algorithm has been created from the PM Dataset (Riedi et al. , 2010) , more investigations are needed for this new phase product, which will help to quantify the value of the combined POLDER/MODIS retrieval techniques. This high confidence dataset could also be used to assess other cloud phase p... | 10.5194/amtd-6-8371-2013 | article | en | 2,013 | true | false | false | false | Environmental Science | https://openalex.org/fields/23 |
cc-by | within each POLDER superpixel via a nearest pixel approximation collocation. The final joint products thus provide all coincident POLDER and MODIS cloud products at the same spatial resolution of about 20 × 20 km 2. Note that the official cloud phase products from MODIS use index values representation (1 for ice, 2 for... | 10.5194/amtd-6-8371-2013 | article | en | 2,013 | true | false | false | false | Environmental Science | https://openalex.org/fields/23 |
cc-by | ACKNOWLEDGEMENTS The author acknowledges the financial support of the French Agence Nationale de la Recherche (ANR) , under grant NAPOLECO ( ANR-2010-INTB-910-01 ). | 10.1201/b14964-128 | book-chapter | en | 2,013 | false | false | true | false | Materials Science | https://openalex.org/fields/25 |
cc-by | Conclusions Although they are independent modelling approaches, both tectonic reconstructions and convection models with plate-like behaviour and continental lithosphere converge to support that seafloor spreading fluctuates significantly over 200 My. Indeed, the shape of the area-age distribution is time-dependent and... | 10.1016/j.epsl.2013.09.032 | article | en | 2,013 | true | false | false | false | Earth and Planetary Sciences | https://openalex.org/fields/19 |
cc-by | allowing us to track the properties of the plates themselves through time. In the Triassic, the vast Panthalassic and the smaller Tethys Ocean sur-rounded the supercontinent, Pangaea. Panthalassa, modeled as a simple three plate spreading system between the Izanagi, Farallon and Phoenix plates dominated the planet, acc... | 10.1016/j.epsl.2013.09.032 | article | en | 2,013 | true | false | false | false | Earth and Planetary Sciences | https://openalex.org/fields/19 |
cc-by | The initial break-up separated Pangaea into Laurentia, Laurasia and the China/Amuria block in the northern hemisphere and Gondwanaland in the southern hemisphere. The birth of the Pacific plate within Panthalassa at 190 Ma and the change from rift to drift along the central Atlantic initiated a period of younging of th... | 10.1016/j.epsl.2013.09.032 | article | en | 2,013 | true | false | false | false | Earth and Planetary Sciences | https://openalex.org/fields/19 |
cc-by | The higher proportion of new crust produced at the mid ocean ridges compared to old crust being destroyed along the subduction zones of the northern Tethys and circum-Panthalassa is reflected in the change from a rectangular-like area-age distribution during Pangaea amalgamation towards a triangular distribution, refle... | 10.1016/j.epsl.2013.09.032 | article | en | 2,013 | true | false | false | false | Earth and Planetary Sciences | https://openalex.org/fields/19 |
cc-by | Acknowledgements We thank Allen K. McNamara and an anonymous reviewer for constructive comments and questions. This research has received funding from Institut Universitaire de France and Crystal2Plate , a FP-7 funded Marie Curie Action under grant agreement number PITN-GA-2008-215353. Calcula-. | 10.1016/j.epsl.2013.09.032 | article | en | 2,013 | false | false | true | false | Earth and Planetary Sciences | https://openalex.org/fields/19 |
cc-by | Growth curves and parameter determination The nine strains were grown in MMB plus 0. 15% yeast extract, with 2% glucose or 2% oleic acid, in 500-ml Erlenmeyer baffled flasks, to improve the dispersion of alkanes and oxygen supply [30]. Cells from overnight YPD cultures were used to inoculate the culture at an initial ... | 10.1371/journal.pone.0063356 | article | en | 2,013 | false | true | false | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | 25 mm, 0,25 mm). FA were identified by comparison with commercial FA methyl ester standards (FAME32; Supelco) and quantified by the internal standard method, involving the addition of 75 mg of commercial C17:0 (Sigma). We determined the FA compositions from chromatograms with custom-developed Python and R software scri... | 10.1371/journal.pone.0063356 | article | en | 2,013 | false | true | false | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | Use of non hydrophobic carbon sources Carbon assimilation tests have been performed for identification of the different species of the Yarrowia clade [18, 19, 20, 21, 22, 23]. However, to obtain a homogeneous set of data, we assessed the ability of the nine strains to use 31 compounds. API galleries were initially use... | 10.1371/journal.pone.0063356 | article | en | 2,013 | true | false | false | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | The results of these tests indicated that some hydrophobic substrates neither supported nor inhibited cell growth. The two exceptions were the two C6 compounds (hexanoic acid and methyl hexanoic acid), which strongly inhibited all strains, although YAPH and YAHI were able to grow on YP-methyl hexanoic after 20 days. Si... | 10.1371/journal.pone.0063356 | article | en | 2,013 | true | false | false | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | 10 OD 600 units after about 23 h of growth, with a generation time of 2. 06 h. By contrast, YAGA seemed be assimilate oleic acid much less efficiently, with a generation time almost twice that of YAHI. We were therefore unable to use the standard protocols for estimating lipid storage in Y. lipolytica. Thus, to ensure ... | 10.1371/journal.pone.0063356 | article | en | 2,013 | true | false | false | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | Discussion We analyzed eight closely related species of the Yarrowia clade, to obtain preliminary data concerning their physiology and, in particular, their ability to grow on and to assimilate HS, before beginning comparative genomic and transcriptomic studies. All the data discussed below were obtained from a single ... | 10.1371/journal.pone.0063356 | article | en | 2,013 | true | false | false | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | Acknowledgments We thank Thanos Beopoulos , Vincent Sauveplane and Thierry Dulermo for technical assistance with lipid content analysis and stimulating discussions. | 10.1371/journal.pone.0063356 | article | en | 2,013 | false | false | true | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | SM has a PhD fellowship funded by the French Minister of Research via the ABIES doctoral school. This work was supported in part by the Institut National de la Recherche Agronomique (INRA) and additionally by the SAS PIVERT , in the frame of the French Institute of Excellence in the field of Low-Carbon Energies... | 10.1371/journal.pone.0063356 | article | en | 2,013 | false | false | true | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | We comment further on this below when discussing comparisons against the ARCTAS data. Comparing FULL and DDEP shows that the best correlation occurs when emissions, enhanced deposition and chemical production terms, are included in the simulation. Figure 8 shows the corresponding comparison against the PEM-tropics B ... | 10.5194/acpd-13-20111-2013 | preprint | en | 2,013 | true | false | false | false | Earth and Planetary Sciences | https://openalex.org/fields/19 |
cc-by | Acknowledgements. The authors would like to thank L. Emmons ( NOAA ) for processing the PEM tropics measurement data and providing it for download. We would also like to thank P. le Sager and T. P. C van Noije for implementing bug fixes to the TM5 model. Edited by: T. Butler. | 10.5194/acpd-13-20111-2013 | preprint | en | 2,013 | false | false | true | false | Earth and Planetary Sciences | https://openalex.org/fields/19 |
cc-by | Determination of Pulmonary Function Pulmonary function was estimated from the spirometric data FEV1, representing the forced expiratory volume in one second. To assess the variation of pulmonary function versus time during the first six months after transplantation, FEV1 ratios were calculated from the ratio of the dif... | 10.1371/journal.pone.0059634 | article | en | 2,013 | true | false | false | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | Statistical Analysis The values are expressed as the means6SD or the medians and percentiles. For the evaluation of the relationship between CNa and acute rejection, CN-a values were censored when patients received a first IV bolus of steroids. Kernel smoothing curves were generated and the dispersion of extreme CN-a v... | 10.1371/journal.pone.0059634 | article | en | 2,013 | false | true | false | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | A large dispersion of CN-a values was observed, and since no reproducible pattern in CN-a could be discerned, we chose to express the CN-a data using their quartile range. For the We compared CN-a expression prior to transplantation in patients with or without cystic fibrosis (CF) since it is the main initial end-stage... | 10.1371/journal.pone.0059634 | article | en | 2,013 | true | false | false | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | Acknowledgement We thank anonymous reviewers for insightful suggestions. ML was supported by the TULIP Laboratory of Excellence ( ANR-10-LABX-41 ). | 10.1016/j.baae.2013.09.001 | article | en | 2,013 | false | false | true | false | Environmental Science | https://openalex.org/fields/23 |
cc-by | Acknowledgements This work was done in conjunction with the International Space Science Institute (ISSI) International Team on Comparative Induced Magnetospheres. FGG is funded by a CSIC JAE-Doc contract co-financed by the European Social Fund. | 10.1002/grl.50709 | article | en | 2,013 | false | false | true | false | Physics and Astronomy | https://openalex.org/fields/31 |
cc-by | Molecular docking of TC-AMP into the active site of PaKae1 Molecular docking was performed as blind docking by using the Autodock Vina 1. 1. 2 software (35) from the MGLTools 1. 5. 6 package (Molecular Graphics Laboratory of The Scripps Research Institute). This method refers to the use of a grid box that is large enou... | 10.1093/nar/gkt720 | article | en | 2,013 | false | true | false | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | Interestingly, whereas the ATPase activity of the whole PaKEOPS complex is stimulated by the presence of tRNA, the ATPase activity of the Kae1-Bud32 complex is independent of tRNA, suggesting that Pcc1 and/or Cgi121 were required for the response to tRNA. To test this hypothesis, we compared the ATPase activity of Kae1... | 10.1093/nar/gkt720 | article | en | 2,013 | true | false | false | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | In line with this observation, the analysis of the same reaction mixture by TLC revealed the release of free inorganic phosphate, indicative of an ATPase activity. These results indicated that the autophosphorylation activity of Bud32 is modified in the context of the PaKEOPS complex. Because Bud32 interacts with Kae1 ... | 10.1093/nar/gkt720 | article | en | 2,013 | true | false | false | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | Consistent with our data, the structural study of KEOPS complex reported only the purification of the Kae1-Bud32-Cgi121 ternary complex (2). The structure of this complex revealed that interaction of Cgi121 with Bud32 altered significantly the conformation of Bud32, suggesting that binding of Cgi121 to Bud32 might prov... | 10.1093/nar/gkt720 | article | en | 2,013 | true | false | false | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | coli ThrRS numbering). This suggests that the metal-based mechanism for the recognition of threonine was acquired independently in two unrelated protein lineages and thus illustrates another case of convergent evolution. Kae1 and Pcc1 form the tRNA binding core of the KEOPS complex Using EMSA experiments, we showed tha... | 10.1093/nar/gkt720 | article | en | 2,013 | true | false | false | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | cerevisiae carrying the same mutation exhibited a severe growth phenotype (2). Taken together, these observations are compatible with a possible role of the Bud32 tail in regulating tRNA binding to the KEOPS complex. Putative mechanistic model for the catalysis of the threonyl-carbamoyl transfer to tRNA by KEOPS Based... | 10.1093/nar/gkt720 | article | en | 2,013 | true | false | false | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | ACKNOWLEDGEMENTS We thank Bruno Collinet and Joseph Bareille for the generous gift of run-off transcripts of tRNA genes. We also thank Herman van Tilbeurgh , Bruno Collinet , Wenhua Zhang , Marie-Claire Daugeron and Domenico Libri for their comments on our work and many fruitful discussions. | 10.1093/nar/gkt720 | article | en | 2,013 | false | false | true | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | FUNDING Funding for open access charge: This work was supported by the Agence Nationale de Recherche [ ANR-09-BLAN-0349 to P. F. ]; a Ph. D. fellowship from ENS Lyon (to L. P. ). | 10.1093/nar/gkt720 | article | en | 2,013 | false | false | true | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | Sarcopenia was defined according to the ASD EWGSOP. The ASD combines an estimate of muscle mass and function, in addition to physical performance. Muscle mass was assessed by means of calf circumference, with a cut-off point of 31cm or less for diminished muscle mass, as described by Rolland et al (16). Muscle functio... | 10.1007/s12603-012-0434-0 | article | en | 2,013 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | All significant variables in these first analyses were entered in a multiple Cox-regression model to test the independent association between the variables and survival. Unadjusted and adjusted hazard ratios (HR) with 95% confidence intervals were reported. In addition, predictive values for mortality were calculated f... | 10.1007/s12603-012-0434-0 | article | en | 2,013 | true | true | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | The LHC is currently stopped for accelerator upgrade and should restart beginning 2015 for a period of three years. An integrated luminosity of 75-100 fb -1 at a center of mass energy from 13 to 14 TeV (Run 2) is expected. Afterwards, two data taking periods called LHC (approved) and HL-LHC (not approved yet) are expec... | 10.1016/j.nuclphysbps.2013.10.027 | article | en | 2,013 | true | false | false | false | Physics and Astronomy | https://openalex.org/fields/31 |
cc-by | Supersymmetry The observation of the Higgs boson with a mass of 125 GeV increases the need of finding a solution to the stability of its mass to large quantum corrections (the so-called hierarchy problem). Natural supersymmetry is one of the most effective and popular solutions to this problem. No evidence of this mode... | 10.1016/j.nuclphysbps.2013.10.027 | article | en | 2,013 | true | false | false | false | Physics and Astronomy | https://openalex.org/fields/31 |
cc-by | INTRODUCTION Titan's atmosphere is composed mainly of N 2 with a few percent of CH 4. Knowledge of the distribution of these constituents with altitude, latitude, and longitude is key to constraining the atmospheric structure and dynamics, and thereby investigating energy and momentum balance in the upper atmosphere. T... | 10.1088/2041-8205/766/2/l16 | article | en | 2,013 | true | false | false | false | Physics and Astronomy | https://openalex.org/fields/31 |
cc-by | Flyby T53 took place on 20 April 2009. We retrieved reliable data for densities in the 849 -1404 km region, near the evening terminator. The geometry of observation, including the tangent altitude or shortest distance between the UVIS line of sight and Titan's surface, was calculated by using the SPICE system developed... | 10.1088/2041-8205/766/2/l16 | article | en | 2,013 | true | false | false | false | Physics and Astronomy | https://openalex.org/fields/31 |
cc-by | 2002; Samson et al. 1987 ) not included in the calculations described above. These N 2 and CH 4 cross sections are measured only at room temperature; therefore the variation of absorption coefficient with temperature is not accounted for in this study. This variation is expected to be small in the wavelength region use... | 10.1088/2041-8205/766/2/l16 | article | en | 2,013 | true | false | false | false | Physics and Astronomy | https://openalex.org/fields/31 |
cc-by | The temporal and spatial variability of the N2 densities precludes us from providing strong constraints on the INMS calibration. Nevertheless, the agreement between our profiles and the INMS profiles shown suggests that the scaling factor of 2. 9 is appropriate for N2. Interestingly, our CH 4 profile differs from the U... | 10.1088/2041-8205/766/2/l16 | article | en | 2,013 | true | false | false | false | Physics and Astronomy | https://openalex.org/fields/31 |
cc-by | SUMMARY We present the first analysis of a solar occultation by Titan's atmosphere observed with Cassini/UVIS. The densities shown are comparable to most of those presented in previous work, within factors 1 -3. The derived temperature is comparable with that obtained from INMS and UVS measurements. The data presented ... | 10.1088/2041-8205/766/2/l16 | article | en | 2,013 | true | false | false | false | Physics and Astronomy | https://openalex.org/fields/31 |
cc-by | Methods/design RESILIENCE is a multinational, randomized, doubleblind, placebo-controlled, phase 3 trial designed to assess the efficacy and safety of sorafenib in combination with capecitabine in patients with locally advanced or metastatic HER2-negative breast cancer who received previous treatment with a taxane and ... | 10.1186/1745-6215-14-228 | article | en | 2,013 | false | false | false | true | Medicine | https://openalex.org/fields/27 |
cc-by | Discussion Data from the SOLTI-0701 showed a statistically significant improvement in PFS when sorafenib was added to capecitabine as a first-or second-line treatment and supported and informed the development of the phase 3 RESILIENCE study [26]. The RESILIENCE study is similar in design to SOLTI-0701 but with some d... | 10.1186/1745-6215-14-228 | article | en | 2,013 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | 67; 95% CI = 0. 40 to 1. 11) but not in the second-line treatment subgroup (HR = 1. 08; 95% CI = 0. 65 to 1. 78). The PROs of RESILIENCE will help to better define the benefit-to-risk profile of the sorafenib-capecitabine combination. Maintaining patient QoL has become an important clinical goal of MBC treatment. Altho... | 10.1186/1745-6215-14-228 | article | en | 2,013 | true | false | false | false | Medicine | https://openalex.org/fields/27 |
cc-by | Acknowledgments The authors acknowledge the writing assistance of Linda Henson and Michael Raffin ( Fishawack Communications ), which was supported by Bayer HealthCare Pharmaceuticals and Onyx Pharmaceuticals. The RESILIENCE study is sponsored by Bayer HealthCare Pharmaceuticals and supported by Onyx Pharmaceut... | 10.1186/1745-6215-14-228 | article | en | 2,013 | false | false | true | false | Medicine | https://openalex.org/fields/27 |
cc-by | Acknowledgments The authors acknowledge the writing assistance of Linda Henson and Michael Raffin ( Fishawack Communications ), which was supported by Bayer HealthCare Pharmaceuticals and Onyx Pharmaceuticals. The RESILIENCE study is sponsored by Bayer HealthCare Pharmaceuticals and supported by Onyx Pharmaceut... | 10.1186/1745-6215-14-228 | article | en | 2,013 | false | false | true | false | Medicine | https://openalex.org/fields/27 |
cc-by | myosuroides ACCase (Genbank/EMBL accession AJ310767). This amplicon thus encompasses codons 1753 to 1794. Primer ACVII27 was fully homologous to the ACCase sequence of A. myosuroides. dCAPS primer ACVII-NspIR contained one mismatched nucleotide at its penultimate position to create a NspI recognition site specifically ... | 10.1371/journal.pone.0075117 | article | en | 2,013 | true | false | false | false | Agricultural and Biological Sciences | https://openalex.org/fields/11 |
cc-by | Statistical analyses Binomial confidence intervals were estimated with R [26] using Bayesian inference as implemented in the package binom [27]. | 10.1371/journal.pone.0075117 | article | en | 2,013 | false | true | false | false | Agricultural and Biological Sciences | https://openalex.org/fields/11 |
cc-by | Acknowledgements The authors are grateful to the curators of the herbaria of Dijon (France), Geneva (Switzerland) and Montpellier (France) for allowing access to plant material, to the Service de Séquençage et de Génotypage of the SERCOBIO (INRA -Université de Bourgogne, Dijon, France) for allowing access to thei... | 10.1371/journal.pone.0075117 | article | en | 2,013 | false | false | true | false | Agricultural and Biological Sciences | https://openalex.org/fields/11 |
cc-by | Magnetic Protostars and Planets (MaPP) is a project aiming at measuring the large-scale topologies in a small sample of about 15 prototypical cTTSs of various masses and ages, and at assessing, on the basis of theoretical modelling, whether and how these fields are able to control/contribute to the observed dissipation... | 10.1093/mnras/stt1622 | article | en | 2,013 | true | false | false | false | Physics and Astronomy | https://openalex.org/fields/31 |
cc-by | Ca II IRT emission Narrow emission in the core of Ca II IRT lines is a very convenient proxy of accretion at the surface of low-mass cTTSs, despite tracing simultaneously their non-accreting chromospheres. Being formed closer to the stellar surface and in a more static atmosphere than the He I D 3 emission line (the us... | 10.1093/mnras/stt1622 | article | en | 2,013 | true | false | false | false | Physics and Astronomy | https://openalex.org/fields/31 |
cc-by | We carry out several tests to determine if kinematic inversion models of limited resolution may still carry useful information on the scaling of dynamic source properties. We take advantage of a large earthquake rupture model database (now at http://equake-rc. info/srcmod/), and analyse a suite of 31 rupture models fro... | 10.1093/gji/ggt478 | article | en | 2,013 | true | false | false | false | Earth and Planetary Sciences | https://openalex.org/fields/19 |
cc-by | Data and data preparation To analyse the distribution and scaling of the average dynamic parameters, we use a dataset of 31 finite-source rupture models obtained by kinematic inversion, from 21 crustal events with various styles of faulting (Table 1 ). Rupture models have been selected based on the availability of a c... | 10.1093/gji/ggt478 | article | en | 2,013 | true | false | false | false | Earth and Planetary Sciences | https://openalex.org/fields/19 |
cc-by | DY N A M I C PA R A M E T E R S V E R S U S C U M U L AT I V E S L I P Some recent studies adress the link between long-term properties of faults, like the degree of 'maturity', and earthquakes dynamics or ground-motion (e. g. Manighetti et al. 2007; Choy & Boatwright 2009; Radiguet et al. 2009). The fault maturity dep... | 10.1093/gji/ggt478 | article | en | 2,013 | true | false | false | false | Earth and Planetary Sciences | https://openalex.org/fields/19 |
cc-by | (1996) , Dreger (1994) and Hartzell et al. (1996) , respectively. at King Abdullah University of Science and Technology on May 20, 2015 http://gji. oxfordjournals. org/ Downloaded from Table 5. Inversion parameters used by different authors for the 1994 M 6. 7 Northridge earthquake, and inferred values of averaged ... | 10.1093/gji/ggt478 | article | en | 2,013 | true | false | false | false | Earth and Planetary Sciences | https://openalex.org/fields/19 |
cc-by | This was the case for the 1999 Izmit earthquake, associated with high σ A and large cumulative slip. However, given the limited number of reported super-shear ruptures, there is no statistical meaningful database at present to further examine this scaling aspect in detail. Note that the rupture of the 1979 Imperial Val... | 10.1093/gji/ggt478 | article | en | 2,013 | true | false | false | false | Earth and Planetary Sciences | https://openalex.org/fields/19 |
cc-by | Source inversion models used in this study. Events and source models were selected from the database of finite-source rupture models (http:/equake-rc. info/srcmod), except for Miyagi-Iwate Nairiku. | 10.1093/gji/ggt478 | article | en | 2,013 | true | false | false | false | Earth and Planetary Sciences | https://openalex.org/fields/19 |
cc-by | A C K N O W L E D G E M E N T S We thank Michel Bouchon , Fabrice Cotton , Francois Renard and Jean Virieux for discussions. This work as been supported by the NERA project ( Network of European Research Infrastructures for Earthquake Risk Assessment and Mitigation ) from the 7th Framework Programme by the Eur... | 10.1093/gji/ggt478 | article | en | 2,013 | false | false | true | false | Earth and Planetary Sciences | https://openalex.org/fields/19 |
cc-by | for supporting next-gen sequencing among the Berkeley Natural History Museums ; and T. Gregory for providing cycad tissue and fi nancial support. Additional funding was provided by the National Science Foundation ( IOS 0845641 , DEB 1110461 ), the University of California Institute for Mexico (UC MEXUS)-Consejo ... | 10.3732/apps.1300070 | article | en | 2,013 | false | false | true | false | Agricultural and Biological Sciences | https://openalex.org/fields/11 |
cc-by | The background recognition plays an important role in the KRATTA experimental data analysis. It allows to isolate the background hits underneath the isotopic lines and thus to perform reliable reconstruction of primary yields. The presented procedure was based on the Kohonen Neural Network and the analysis allowed to r... | 10.5506/aphyspolbsupp.6.1115 | article | en | 2,013 | true | false | false | false | Computer Science | https://openalex.org/fields/17 |
cc-by | We acknowledge the support by the Foundation for Polish Science -MPD program , co-financed by the European Union within the European Regional Development Fund and funding by the Polish Ministry of Science and Higher Education under grant No. DPN/N108/GSI/2009. | 10.5506/aphyspolbsupp.6.1115 | article | en | 2,013 | false | false | true | false | Computer Science | https://openalex.org/fields/17 |
cc-by | 0; Lynnon BioSoft, Quebec, Canada). Sequences generated from representatives of MEAM1 and Med previously collected in Morocco (Tahiri et al. 2006) were included in the comparison. A phylogenetic tree was set up with a Jukes and Cantor distance matrix using the neighbor-joining method of DNA-MAN (Saitou and Nei 1987)... | 10.1002/ece3.655 | article | en | 2,013 | false | true | false | false | Agricultural and Biological Sciences | https://openalex.org/fields/11 |
cc-by | The resulting adjusted P-values are called Q-values. This procedure is implemented in the R package QVALUE (Storey and Tibshirani 2003). Mean number of alleles per locus ( A), observed heterozygosities (H O ), and unbiased expected heterozygosities (H E , calculated following Nei [1973] ) were calculated using GENETI... | 10.1002/ece3.655 | article | en | 2,013 | false | true | false | false | Agricultural and Biological Sciences | https://openalex.org/fields/11 |
cc-by | Population differentiation tests Pairwise F ST estimates were obtained using GENEPOP. A hierarchical analysis of molecular variance (AMOVA) was performed, using HIERFSTAT (Goudet 2005) , to test for geographical structure. This test was performed on eight Med populations using four hierarchical levels: individuals wit... | 10.1002/ece3.655 | article | en | 2,013 | false | true | false | false | Agricultural and Biological Sciences | https://openalex.org/fields/11 |
cc-by | Hybrid detection We used the NEWHYBRIDS (1. 1) software that implements a Bayesian assignment approach dedicated to the quantification of hybridization events from individual multilocus genotypes (Anderson and Thompson 2002). The strength of this method is that no pedigree information is required, allowing application... | 10.1002/ece3.655 | article | en | 2,013 | false | true | false | false | Agricultural and Biological Sciences | https://openalex.org/fields/11 |
cc-by | tabaci was above the 3. 5% divergence threshold characteristic of a new putative species (Dinsdale et al. 2010). It was also above the 3. 5% divergence threshold with the putative species "Ru" recently detected in Italy (Parrella et al. 2012). The smallest divergence was obtained with the consensus of the Italy group... | 10.1002/ece3.655 | article | en | 2,013 | true | false | false | false | Agricultural and Biological Sciences | https://openalex.org/fields/11 |
cc-by | Spatial distribution and evolution over time of individuals of MEAM1 and Med species The abundance of individuals belonging to MEAM1 species compared to those belonging to Med species (assessed from the distribution of the 341 unambiguously Table 1 ). The GenBank sequences are identified by their accession number and... | 10.1002/ece3.655 | article | en | 2,013 | true | false | false | false | Agricultural and Biological Sciences | https://openalex.org/fields/11 |
cc-by | The two Med hybrids were detected in the only field where no MEAM1 representatives were found, which is apparently surprising but not unexpected because the hybrids were not from an F1 generation. Consistently, MEAM1 individuals were detected in the same field or at least in a neighboring field 2 years before. The dete... | 10.1002/ece3.655 | article | en | 2,013 | true | false | false | false | Agricultural and Biological Sciences | https://openalex.org/fields/11 |
cc-by | Figure2. Rooted neighbor-joining tree based on a 587-nucleotide fragment of the mtCOI gene of Bemisia tabaci. The sequences generated in this study are identified by their accession number and the code number of the corresponding whitefly (see Table1). The GenBank sequences are identified by their accession number and ... | 10.1002/ece3.655 | article | en | 2,013 | true | false | false | false | Agricultural and Biological Sciences | https://openalex.org/fields/11 |
cc-by | Acknowledgments This study was funded by two projects within the program " Projet de Recherche Agronomique pour le D eveloppement " ( PRAD 01/14 and PRAD 04/04 ) and the project " BemisiaRisk " within the program " Agriculture et D eveloppement Durable " of the Agence Nationale de la Recherche (http://www. agence-n... | 10.1002/ece3.655 | article | en | 2,013 | false | false | true | false | Agricultural and Biological Sciences | https://openalex.org/fields/11 |
cc-by | Funding Information This study was funded by two projects within the program " Projet de Recherche Agronomique pour le D eveloppement " ( PRAD 01/14 and PRAD 04/04 ) and the project " BemisiaRisk " within the program " Agriculture et D eveloppement Durable " of the Agence Nationale de la Recherche (http:// www. age... | 10.1002/ece3.655 | article | en | 2,013 | false | false | true | false | Agricultural and Biological Sciences | https://openalex.org/fields/11 |
cc-by | 5 for the fluorescein-labeled ZF and of 17,940, 1,370, and 2,740 M Ϫ1 ⅐cm Ϫ1 at 280 nm for F-ZF, mono-Ub, and di-Ub, respectively. Sedimentation Velocity (SV) Analytical Ultracentrifugation (AUC)-Sedimentation velocity experiments were carried out at 20 °C in a Beckman Coulter XL-I analytical ultracentrifuge equipped w... | 10.1074/jbc.m113.483305 | article | en | 2,013 | true | false | false | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | The partial specific volume (v bar ) as well as the extinction coefficient (⑀) at 280 nm of ZF and different di-ubiquitins were calculated at 20 °C from their amino acid composition using Sednterp software Version 1. 09. Similarly, the density and the viscosity of the buffer were calculated with the same software. Diff... | 10.1074/jbc.m113.483305 | article | en | 2,013 | false | true | false | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
cc-by | 6 mM ZnCl 2. The emission spectra and the fluorescence quantum yields were obtained using an N-acetyl tryptophanamide (Sigma) standard as described previously (15). Structural Modeling-The ZF⅐Lys-63 di-Ub complex shown in Fig. 7 , A and B, was generated using the standard protocols implemented in HADDOCK 2. 0 (34) wit... | 10.1074/jbc.m113.483305 | article | en | 2,013 | true | false | false | false | Biochemistry, Genetics and Molecular Biology | https://openalex.org/fields/13 |
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