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ART001373807 | oai_dc | 발기부전과 하부요로증상이 동반된 환자들에서 SS-penogram 분류에 따른 배뇨기능의 분석 | Comparison of Voiding Parameters According to the Subtypes of SS-Penogram in Patients with Both Erectile Dysfunction and Lower Urinary Symptoms | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"최현민(연세대학교); 최형기(연세대학교); 김철응(연세대학교); 정병하(연세대학교)"
] | Purpose: We investigated the results of voiding parameters according to the subtypes of audiovisual stimulation (AVS)- and sexual stimulation (SS)-penogram in patients with both erectile dysfunction (ED) and lower urinary tract symptoms (LUTS).
Materials and Methods: Sixty seven patients with ED and LUTS were included in this study. Erectile function was evaluated by international index of erectile function (IIEF)-5, AVS-penogram, and SS-penogram. After AVS-penogram, SS-penogram was performed 30 minutes after taking mirodenafil (100mg) orally. We also evaluated voiding function with international prostatic symptom score (IPSS), quality of life score (QoL), urinary flow rate (UFR), residual urine volume (RV), and transrectal ultrasonograpy (TRUS). Voiding functionparameters were analyzed according to the subtypes of AVS- and SS-penogram.
Results: Although there was tendency that the IIEF-5 scores were lower in patients who showed decreased erectile responses on AVS-penogram, but it did not reach the statistical significance (p= 0.09). The RV was significantly increased as the erectile function worsens based on AVS-penogram (p= 0.003). However, no significant relationship was found betweenresults of SS-penogram and voiding function parameters.
Conclusions: Our results revealed some relationship between voiding function and erectile function evaluated by AVS-penogram, but not by SS-penogram, in patients with both ED and LUTS. AVS-penogram, as well as IIEF questionnaire, may play an important role in predicting voiding function in patient with both conditions.
| 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001373873 | oai_dc | 전립선 농양에서 영상검사의 중요성과 경직장초음파를 이용한 세침흡입술의 유용성 | Diagnosis of Prostatic Abscess and Utility of Transrectal Ultrasonography Guided Abscess Aspiration | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"이승현(경상대학교); 제성욱(경상대학교); 정재훈(경상대학교); 정기현(경상대학교); 현재석(경상대학교); 서덕하(경상대학교)"
] | Purpose: Prostatic abscess is a very rare disease whose incidence has been reported to be approximately 0.2% in patients with urologic symptoms. Besides, it cannot be diagnosed by interview and physical examination, for which imaging studies must also be performed. In the current study, we examined the clinical usefulness of imaging studies in making a diagnosis of prostatic abscess and the effect of a fine needle aspiration based on trans-rectal ultrasonography on the treatment outcomes.
Materials and Methods: In ten patients who were diagnosed with prostatic abscess and then treated during a period ranging from January of 1995 to June of 2008 (mean age: 61.8 years, range: 40-89 years), a past history, clinical symptoms, physical examination findings, laboratory findings, trans-rectal ultrasonography findings, computed tomography findings, treatment modalities and complications were retrospectively analyzed.
Results: All patients complained fever and voiding dysfunction as chief complaint. On trans-rectal ultrasonography and computed tomography scans, all the ten patients had abnormal findings. In five patients, there were nonhomogenous hypo-echoic lesions on trans-rectal ultrasonography. All the patients had cystic abscess lesions detected on computed tomography scans. In four patients, in whom the diameter of lesions was greater than 1cm on computed tomography scans, a fine needle aspiration was performed on trans-rectal ultrasonography and antibiotic treatment was performed. In six patients, in whom the diameter of lesions was smaller than 1 cm on computed tomography scans, antibiotic treatment was performed. There were statistically significant differences in the length of hospital stay and the size of prostate gland between the group where a fine needle aspiration was performed using trans-rectal ultrasonography and the group where antibiotic treatment was performed (P<0.05). However, there was no significant difference in the period of antibiotic treatment (P>0.05). Length of antibiotic therapy was shorter in antibiotic therapy only group, but there was no statistically significant difference (P>0.05).
Conclusions: A computed tomography is a useful diagnostic modality for prostatic abscess. Besides, a fine needle aspiration based on trans-rectal ultrasonography is one of the minimally invasive treatment regimens for prostatic abscess, whose good treatment outcomes have been well documented. Furthermore, there were no severe complications in our series.
| 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001373876 | oai_dc | 30∼50gm의 전립선비대증 환자에서 방광 내 전립선 돌출이 하부요로증상에 미치는 영향 | The Clinical Implication of Intravesical Prostatic Protrusion to Lower Urinary Tract Symptoms in Patients of Prostatic Volume 30∼50gm | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"이준민(건국대학교); 홍우성(건국대학교); 정홍(건국대학교); 백성현(건국대학교); 양상국(건국대학교)"
] | Purpose: Intravesical prostatic protrusion (IPP) is a morphological change of prostate protruded into bladder and might be related to bladder outlet obstruction (BOO) depending on the extent of protrusion. There is a high possibility that lower urinary tract symptoms (LUTS) tends to get worse as IPP grows. Therefore, it is necessary to examine the effect of IPP on LUTS after revision of prostate volume in order to identify the direct effect of IPP on BOO and LUTS.
Materials and Methods: A retrospective study of 296 male patients diagnosed with benign prostate hyperplasia (BPH) between August 2006 and December 2008 were performed. The patients were evaluated with international prostate symptoms score (IPSS) and quality of life (QoL), uroflowmetry (UFR), post-void residual urine volume (PVR), prostate volume and IPP as measured by transurectal ultrasound (TRUS). The changes of IPSS after 8 weeks of medication treatment and the occurrence rates of transurethral resection of prostate (TURP) and acute urinary retention (AUR) were compared. By checking IPSS and UFR, the improvement of voiding symptom was evaluated.
Results: The population of patients with moderate enlargement (30-50gm) of prostate extent was 147 (49.6%) out of 296, the whole examined population. There were correlation between IPP and IPSS (p=0.002) and the storage symptoms score was significantly increased (p=0.014). After 8 weeks of medication treatment, both moderate BPH patients with IPP showed similar improvement in storage symptom compared to non-IPP groups. But, the TURP was significantly performed more with IPP (p=0.040) than non-IPP groups and more AUR has occurred (p=0.013). After TURP, IPP group resulted in improvement of IPSS, storage symptoms score and voiding symptoms score statistically compared to non-IPP group. As the change of UFR and IPSS after TURP had shown, the improvements of voiding volume, maximal flow rate (Qmax), and average flow rate (Qavg) in IPP groups were smaller however, it is no correlation in statistical view.
Conclusions: Moderate BPH group with IPP has a higher possibility of having AUR and surgical treatment while showing significant correlation with storage symptoms. A further prospective study is necessary for identification of improvement of IPSS and UFR after TURP and IPP should be checked carefully during TRUS.
| 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001373879 | oai_dc | The Efficacy and Safety of Tamsulosin 0.2mg/day on Sexual Function in BPH: A Multicenter Open-label, Non-comparative, 3 Months Observational, Phase IV Prospective Study | The Efficacy and Safety of Tamsulosin 0.2mg/day on Sexual Function in BPH: A Multicenter Open-label, Non-comparative, 3 Months Observational, Phase IV Prospective Study | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"문두건(고려대학교); 이성원(성균관대학교); 문기학(영남대학교); 안태영(울산대학교); 정우식(이화여자대학교); 양대열(한림대학교); 김제종(고려대학교); 배영대(고려대학교)"
] | Purpose: The aim of this study was to assess the efficacy and safety of tamsulosin, 0.2mg/day on sexual function in Korean BPH patients.
Patients and Methods: 116 patients (mean age: 60 yrs) with BPH were enrolled in this study and 0.2mg of tamsulosin was administrated every night for 3 months. Primary efficacy was evaluated with changes of IIEF and GEQ. Secondary efficacy parameters were changes of IPSS and QoL, uroflowmetry, changes of total IIEF and IIEF domain score according to the severity of IPSS, and retrograde ejaculation.
Results: Before treatment, patients of moderate IPSS (8-19) and severe IPSS (20-35) were 56% and 44% and QoL<3 and QoL>3 were 33.6% and 66.4%. In primary efficacy evaluation, total IIEF score was significantly increased from 37.0±18.2 to 40.5±18.9 (p<0.01). All domains of IIEF except orgasmic function were significantly improved. GEQ showed improvement of erection in 34.4% and intercourse ability in 30.1%. In secondary efficacy evaluation, IPSS was significantly decreased from 18.4±6.9 to 12.9±6.7 (p<0.01) and QoL was significantly improved from 3.8±1.1 to 2.7±1.4 (p<0.01). Qmax significantly increased from 14.2±8.3 to 16.5±11.3 ml/sec (p<0.01). Total IIEF score and EF domain score were significantly improved
from 36.8±18.5 to 41.8±19.1 (p<0.01) and from 13.0±7.1 to 14.7±7.9 (p<0.01) in patients of moderate IPSS but no improvement in severe patients. Retrograde ejaculation occurred in 2 patients (2%). No serious adverse reactions were observed.
Conclusions: Tamsulosin, 0.2mg/day was effective and safe dose for the improvement of LUTS and sexual function for Korean BPH/LUTS patients.
| 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001235117 | oai_dc | 여성 성기능 장애의 진단에서 레이저 도플러 유속측정기 (Laser Doppler Flowmetry) 적용의 초기 경험 | Laser Doppler Flowmetry: Usefulness in Female Sexual Dysfunction | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"이하나(이화여자대학교); 정우식(이화여자대학교); 심봉석(이화여자대학교); 윤하나(이화여자대학교)"
] | Purpose: Various diagnostic tools have been developed to diagnose and differentiate the causes of female sexual dysfunction. In this study, we used laser Doppler flowmetry to measure the genital blood flow and analyzed its usefulness as a diagnostic tool in patients with sexual dysfunctions.
Materials and Methods: We enrolled 50 female patients with sexual difficulties(45.8±9.8 years old). Ten sexually healthy women were enrolled as a control group. We measured the superficial blood flow of the clitoral glans, vestibule, and anterior wall of the vagina using laser Doppler flowmetry(Periflux 5000, Permed AB, Sweden), and compared these measurements with blood flow measured in response to sexual stimulation induced by an erotic film. Medical and personal histories, physical examinations, and self-reporting questionnaires were taken from the patients for classifying their sexual problems.
Results: The patients complained of problems with desire(46 patients, 92%), arousal(41, 82%), orgasm(49, 98%), pain(10, 20%), and satisfaction(32, 64%). Most patients had more than one problem. In patients with sexual dysfunction, baseline blood flows at all measuring sites were significantly lower than in the control group(p＜0.05). After the sexual stimulation, the blood flows of the glans, vestibule, and anterior vaginal wall were significantly increased(p＜0.0001). In the groups with desire and arousal problems, blood flow changes were significantly less than in the control group.
Conclusions: Laser Doppler flowmetry can provide very useful information on whether patients have hemodynamic-based sexual problems. We can approach the causes of sexual difficulties, particularly sexual desire or arousal problems, using this novel technological instrument.
| 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001235113 | oai_dc | 성욕감퇴가 있으나 정상 혈청 테스토스테론치를 가진 발기부전 환자에서 PDE5 차단제 단독요법과 Trazodone과의 병합요법의 비교 | Combination Therapy of Sildenafil with Trazodone in Erectile Dysfunction Patients with Decreased Libido and Normal Serum Testosterone | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"박민구(고려대학교); 진명헌(고려대학교); 배재현(고려대학교); 김제종(고려대학교); 문두건(고려대학교)"
] | Purpose: This study was done to assess the therapeutic effect of trazodone, an antidepressant agent in combination with sildenafil in patients with erectile dysfunction (ED) and decreased libido with normal serum testosterone level.
Materials and Methods: From March 2005 to February 2006, 90 patients with ED complaining of decreased libido but whose serum testosterone level was within normal range were screened and enrolled in this study. The subjects were randomly treated by sildenafil only (group 1) and combination of sildenafil with trazodone (group 2). Patients received trazodone for at least 3 consecutive months, with daily doses starting at 50 mg. By intention-to-treat basis, the period of study was extended by 9 month. The intention-to-treat population included 39 sildenafil recipients and 35 sildenafil with trazodone recipients. The patients were asked to make up two questions, Q1: ‘Did you experience improvement of erection after treatment?’ and Q2: ‘Did you experience improvement of libido after treatment?’ and the change of International index of erectile function (IIEF) scores before and after the treatment were analyzed to assess the efficacy of treatment.
Results: After 3 month treatment period, 70% of group 1 and group 2 answered ‘yes’ to Q1. Twenty seven percents of group 1 and 51% of group 2 answered ‘yes’ to Q2 and 20% of group 1 and 24% of group 2 answered ‘yes’ to both Q1 and Q2. In the intention-to-treat population, seventy-two percents of group 1 and 71% of group 2 answered ‘yes’ to Q1 and 28% of group 1 and 52% of group 2 answered ‘yes’ to Q2, 21% of group 1 and 26% of group 2 answered ‘yes’to both Q1 and Q2. The change of IIEF scores before and after the treatment at 3 month and 9 month showed similar results. Both group 1 and group 2 showed significant improvement on scores of IIEF-5 and question 15 of IIEF after treatment (p＜0.01). Meanwhile, only group 2 showed significant improvement on question 11 and 13 of IIEF after the treatment compared to group 1 (p＜0.05). Two patients with high dose of trazodone complained of headache and drowsiness, but the symptoms disappeared by dose reduction.
Conclusions: The combination therapy of trazodone with sildenafil increased libido and sexual satisfaction on patients with ED. Therefore, combination of trazodone with sildenafil might be considered in ED patients of decreased libido with normal serum testosterone level rather than sildenafil monotherapy.
| 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001235116 | oai_dc | 첫 번째 생검과 재생검에서 발견된 전립선암의 임상적 특징 | Clinical Features of Prostate Cancer Detected on Initial and Repeated Biopsy | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"손동완(가톨릭대학교); 정윤석(가톨릭대학교); 김성대(가톨릭대학교); 김두배(가톨릭대학교); 김현우(가톨릭대학교); 김세웅(가톨릭대학교); 조용현(가톨릭대학교)"
] | Purpose: To determine the clinical differences between prostate cancer detected on initial biopsy and repeated biopsy
Materials and Methods: Between January 2003 and December 2006, 67 patients were evaluated in this study who were diagnosed prostate cancer by transrectal ultrasound-guided biopsies and their prostate specific antigen (PSA) were below 20 ng/ml and clinical stages were less than T2. Among 67 patients, 43 patients were diagnosed at the first biopsies (group A) and others were diagnosed at the repeate biopsies (group B). We retrospectively characterized differences in clinical features such as age, digital rectal examination (DRE), prostate volume, the number of biopsy core, rate of positive core, PSA, % free PSA, Gleason score and rate of insignificant cancer.
Results: There were no significant differences in age, PSA, % free PSA, rate of insignificant cancer between groups A and B. However, positive rate of DRE, prostate volume and rate of patients whose PSA were 7 ng/ml or higher in group A were significantly higher than those in group B. Despite the number of biopsy core was higher in group A, there were no differences in the number of positive biopsy core.
Conclusions: Compared to the patients who were diagnosed as prostate cancer in the initial biopsies, prostate volume, positive rate of DRE and rate of Gleason score 7 or more were significantly lower in repeated biopsy group. From now on we are planning to include more patients and compare these characteristics of biopsies with the final pathological features after radical prostatectomy.
| 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001235115 | oai_dc | 혈청 전립선특이항원이 4∼10 ng/ml인 환자에서 Dutasteride 투여가 전립선암 발견에 미치는 영향 | Effects of Medication with Dutasteride on Detection of Prostate Cancer in Patients with Serum Prostate-specific Antigen Level of 4∼10 ng/ml | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"신준식(대구파티마병원); 조성룡(대구파티마병원)"
] | Purpose: We assessed the effects of medication with dutasteride on serum prostate-specific antigen (PSA), PSA density (PSAD) and prostate volume to avoid unnecessary biopsies.
Materials and Methods: Between 2005 and 2007 patients with serum PSA level of 4∼10 ng/ml were recruited in this prospective study. Patients were treated with 0.5 mg of dutasteride once daily for 3 months. PSA, PSAD and prostate volume were measured at baseline and at the end of treatment. The patients with a high PSA level (≥4 ng/ml) after medication with dutasteride had a prostate biopsy. The patients were divided as group I (prostate cancer; n=29) and group II (benign disease; n=55). We compared the changes of serum PSA, PSAD, and prostate volume change between two groups.
Results: In group I, PSA, PSAD and prostate volume decreased from baseline means of 8.16 ng/ml, 0.23 ng/ml/cm3 and 46.81 cc to 5.69 ng/ml, 0.18 ng/ml/cm3 and 40.41 cc. The difference in PSA, PSAD and prostate volume was −0.2%, −2.1% and −3.6% for group I. On the contrary, in group II, PSA, PSAD and prostate volume decreased from baseline means of 7.65 ng/ml, 0.16 ng/ml/cm3 and 56.48 cc to 4.48 ng/ml, 0.11 ng/ml/cm3 and 51.35 cc. The difference in PSA, PSAD and prostate volume was −41.4%, −33.3% and −9.1% for group II. When 4.83 ng/ml and 0.15 ng/ml/cm3 were chosen as the PSA and PSAD cutoff levels after treatment with dutasteride, unnecessary biopsies could be avoided effectively.
Conclusions: These data suggest that the magnitude of changes in serum PSA and PSAD after 3 months of dutasteride challenge could be useful to avoid unnecessary prostate biopsies in patients with elevated PSA level.
| 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001235111 | oai_dc | 대사증후군과 남성불임 | Metabolic Syndrome and Male Infertility | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"박현준(부산대학교)"
] | 저자는 대사증후군과 남성불임과의 연관성을 밝힌 여러 연구들의 문헌고찰을 통해 대사증후군의 각 위험 인자들이 직접 혹은 간접적으로 남성의 가임능을 저하시킬 수 있음을 확인할 수 있었다(Figure 1). 현대사회의 경제적, 물질적 풍족함이 식생활을 변화시키고 신체활동을 감소시켜 비만환자가 증가하고 대사증후군의 각 위험인자를 포함하는 여러 성인병, 특히 당뇨병, 고혈압, 고지혈증, 심혈관계 질환이 젊은 연령대의 남성에서 건강의 주요 관심사로 대두되고 있는 현실에서 남성불임 환자를 진단하고 치료할 때 대사증후군의 동반 유무를 면밀히 살피고 또한 생활습관과 환경적 요인 등의 교정 가능한 요소가 있는지를 조사하여 이들을 치료, 개선하는 노력이 동반되어야 할 것으로 생각한다. | 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001235110 | oai_dc | 대사증후군이 남성갱년기증후군의 증상 및 혈중 총 테스토스테론치에 미치는 영향 | Influence of Metabolic Syndrome on Late-onset Male Hypogonadism Symptoms and Serum Total Testosterone Level | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"박현준(부산대학교); 예정우(예비뇨기과); 박창수(부산대학교); 박남철(부산대학교)"
] | Purpose: Although concern about the health disorders in aging men have been growing, the association has not been elucidated in relation to the late onset male hypogonadism(LOH) and metabolic syndrome(MS). In this background, we evaluated the clinical impact of MS on LOH symptoms and serum total testosterone level.
Materials and Methods: 100 patients with LOH symptoms who visited to the urology clinic between May, 2004 and October, 2006 were analyzed. Of all object, 48 patients were associated with MS(Group I) and 52 patients were not(Group II), based on the NCEP-ATP III(2001) guidelines. We compared the LOH status with Saint Louis University Androgen Deficiency in Aging Males(ADAM) questionnaire, serum total testosterone level, as well as prevalence of MS components between the two groups.
Results: The overall prevalence of MS was 48% among LOH patients. The average age of group I and II were 57.7±10.5 and 58.6±11.2 years, respectively. Positivity for ADAM questionnaire was 83.3% in group I and 76.9% in group II, respectively(p＜0.05). Serum total testosterone level decreased according to number of components of MS(p＜0.05). The obesity group had significantly decreased serum total testosterone level(3.41±1.34 ng/ml) comparing to control group(4.41±2.23 ng/ml)(p＜0.05).
Conclusions: MS and its risk factors were significantly associated with LOH symptoms and positively correlated with the severity of disease. The evaluation of MS are required for the diagnosis and treatment of the patients with LOH.
| 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001235112 | oai_dc | 후기 발현 남성 성선기능저하증에 대한 2006 대한남성갱년기학회 호르몬치료 권고안 | 2006 KOSAR Recommendations for Investigation, Treatment and Monitoring of LOH in Males | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"김문종(포천중문의과대학교); 이유미(연세대학교); 서주태(관동대학교); 양대열(한림대학교); 문두건(고려대학교); 박남철(부산대학교); 김제종(고려대학교)"
] | Androgen deficiency in the aging male has become a topic of increasing interest and debate throughout the world. The evidence from results showing that testosterone decrease progressively with age and that a significant percentage of men over the age 60 years have serum testosterone levels that are below the lower limits of young adults(age 20∼30) men suggest that older hypogonadal men will benefit from testosterone replacement therapy. Long term data on the effects of testosterone replacement therapy in the older population, however, are limited and specific risk data on the prostate and cardiovascular systems are needed. Key questions of functional benefits that may retard frailty of the elderly are not yet available. The recommendations described below were based on document suggested by the International Society of Andrology(ISA), the International Society for the Study of the Aging Male(ISSAM) and the European Association of Urology(EAU) in 2005. The academic committee of the Korean Society for the Aging Male Research(KOSAR) suggested these recommendations to provide the appropriate information about investigation, treatment and monitoring for late-onset hypogonadism in aging Korean men following an annual meeting in October 2006.
| 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001235118 | oai_dc | 발기 시 음경통증과 만곡을 동반한 원발성 음경 해면상 혈관종 | Primary Cavernous Hemangioma of Penile Shaft with Painful Erection and Penile Curvature | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"손동완(가톨릭대학교); 정조운(가톨릭대학교); 김성대(가톨릭대학교); 김두배(가톨릭대학교); 김현우(가톨릭대학교); 조용현(가톨릭대학교); 김세웅(가톨릭대학교)"
] | Hemangiomas result from proliferation of immature capillary vessels. This disorder in the genitourinary tract is a rare lesion. We experienced one case of a 31 years old man suffered from cavernous hemangioma of the penis shaft with painful erection. He was treated successfully with surgical excision. Herein, we report our experience and a critical review of the literature.
| 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001235114 | oai_dc | 남성호르몬 보충요법 시 전립선의 안전성에 관한 연구: 전립선특이항원을 중심으로 | Prostate Safety of Androgen Replacement Therapy Focusing on Prostate Specific Antigen | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"이경훈(인제대학교); 최용혁(인제대학교); 조성용(인제대학교); 이건철(인제대학교부속일산백병원); 조인래(인제대학교)"
] | Purpose: The greatest concern in the androgen replacement therapy (ART) is the possible side effects to the prostate. We evaluated the effects of ART focusing on the prostate specific antigen (PSA).
Materials and Methods: From 2003 to 2006, 47 patients 44 to 75 years old (mean age 60.1) received ART. At baseline and after ART, digital rectal examination, serum testosterone and PSA measurement and transrectal ultrasonography were evaluated. Mean follow-up was 7.9 months (range 1 to 41). Patients were classified into two groups based on the initial PSA level, as PSA levels of 2.5 ng/ml or greater (group 1) (n=29) and PSA levels of less than 2.5 ng/ml (group 2) (n=18).
Results: ART significantly increased serum testosterone, PSA and free PSA levels. However, prostate volume did not change significantly. When serum PSA was compared, the increase of PSA levels was greater than in high PSA group (group 1) than in group 2, although the ratio between the two groups in PSA increase was 38.3% for group 2 and 18.2% for group 1, respectively. A total of 4 patients (16.7% of group 1 and 3.4% of group 2) with a serum PSA level greater than 4 ng/ml after ART underwent a prostate biopsy but no patients were found to have prostate carcinoma.
Conclusions: Rates of PSA elevation (＞4 ng/ml) and prostate biopsies were higher in patients with high baseline PSA level (≥2.5 ng/ml) than in those with PSA level less than 2.5 ng/ml who received ART. However, our findings suggest that an increased risk of prostate cancer was not associated with ART.
| 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001215779 | oai_dc | 전립선비대증 환자에서 양극성 경요도전립선절제술의 장기 추적 결과 | Long-term Follow-up of Bipolar Transurethral Resection of the Prostate Compared with Conventional Monopolar Resectoscope for Patients with Benign Prostatic Hyperplasia | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"신홍석(영남대학교); 김현태(영남대학교); 문기학(영남대학교); 박동춘(영남대학교)"
] | Long-term Follow-up of Bipolar Transurethral Resection of the Prostate Compared with Conventional Monopolar Resectoscope for Patients with Benign Prostatic HyperplasiaHong Seok Shin, Hyun Tae Kim, Ki Hak Moon and Tong Choon Park | 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001215781 | oai_dc | 당뇨병 백서에서 제5형 Phosphodiesterase 억제제의 지속 투여가 발기능에 미치는 영향 | Effects of Chronic Treatment with a Type 5 Phosphodiesterase Inhibitor on Erectile Function in Diabetic Rats | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"조민철(서울대학교); 박관진(원자력병원); 백재승(서울대학교)"
] | Effects of Chronic Treatment with a Type 5 Phosphodiesterase Inhibitor on Erectile Function in Diabetic RatsMin Chul Cho, Kwanjin Park* and Jae-Seung Paick | 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001215782 | oai_dc | 백서 질 조직에서 아쿠아포린(Aquaporin)-1의 발현과 골반신경 자극에 의한 전위 | Expression and Translocation of Aquaporin (AQP)-1 after Pelvic Nerve Stimulation in Rat Vagina | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"이현숙(전남대학교); 김선옥(전남대학교); 한호재(서울대학교); 안규윤(전남대학교); 박광성(전남대학교)"
] | Expression and Translocation of Aquaporin (AQP)-1 after Pelvic Nerve Stimulation in Rat VaginaHyun-Suk Lee, Sun-Ouck Kim, Ho Jae Han*, Kyuyoun Ahn† and Kwangsung Park | 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001215775 | oai_dc | 발기부전의 줄기세포치료 | Stem Cell Therapy for Erectile Dysfunction | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"송윤섭(순천향대학교)"
] | 성공적인 발기부전 치료법의 개발에도 불구하고, 근본적으로 발기부전을 치료할 수 없고, 심한 발기부전 환자에서는 효과적이지 않다는 한계점을 지니고 있으므로 새로운 치료법의 필요성이 대두되었다. 줄기세포 치료는 줄기세포가 분화하여 손상된 조직이나 세포의 재생을 촉진하며, 줄기세포 자체에 의한 효과뿐 아니라 줄기세포를 매개로 한 유전자 전달을 통하여 유전적으로 변형된 세포를 안정적으로 전달할 수 있고, 자가세포를 이용할 경우 면역거부반응을 유발하지 않으며, 국소염증반응을 일으키지 않는다는 장점이 있다.배아줄기세포를 신경분화시킨 신경배아줄기세포 치료는 해면체신경 손상 후, 축색돌기 신장을 돕는 세포기질을 제공하며, 신경수초화를 촉진하고, nurofilaments 생성을 통하여, 손상된 신경세포 재생을 촉진하여 발기능을 개선시켰다. 중간엽줄기세포 단독 혹은 중간엽줄기세포 매개 유전자치료는 노령 발기부전 흰쥐의 음경해면체에 투여 후, 중간엽줄기세포가 내피세포와 평활근 세포로 분화하고, 음경해면체 조직에서 eNOS 단백 표현과 NOS 활성 및 cGMP의 을 증가시켜 발기능을 개선시켰다. 횡문근유래줄기 세포치료도 해면체신경 손상 후 음경해면체에 투여하면 손상된 신경의 회복을 촉진하여 발기능을 개선시켰다. 태아줄기세포, 양수유래줄기세포 및 제대혈줄기세포는 다능하여 이들을 이용한 세포치료법도 시도되고 있다.줄기세포 단독 및 줄기세포 매개 유전자치료법은 발기부전을 근본적으로 치료하여 자연스러운 성생활의 회복을 가능하게 할 수 있고, 노령이나 기존 치료에 반응하지 않는 심한 발기부전 환자 및 기존치료의 적용이 불가능하였던 환자들에서 새로운 치료법을 제시할 수 있을 것으로 기대한다. | 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001215778 | oai_dc | 혈액투석을 받는 여성의 성기능장애 | Sexual Dysfunction in Female Patients on Hemodialysis | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"송효정(제주대학교); 허정식(제주대학교)"
] | Sexual Dysfunction in Female Patients on Hemodialysis Hyo Jeong Song and Jung-Sik Huh* | 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001215783 | oai_dc | 부고환의 투명 세포 유두상 낭선종 1례 | Clear Cell Papillary Cystadenoma of the Epididymis Associated with Multiple Renal and Pancreatic Cysts | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"이상욱(한림대학교); 정해원(한림대학교); 김성용(한림대학교); 김하영(한림대학교); 양대열(한림대학교); 조성진(한림대학교)"
] | Clear Cell Papillary Cystadenoma of the Epididymis Associated withMultiple Renal and Pancreatic CystsSang Wook Lee, Hae Won Jung, Sung Yong Kim, Hayoung Kim, Dae Yul Yang and Seong Jin Cho* | 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001215777 | oai_dc | 남성갱년기증후군 환자에서 테스토스테론 겔(테스토겔？) 경피투여의 유효성과 안전성을 평가하기 위한 다기관, 공개연구 | Efficacy and Safety of Testosterone Gel in Korean Men with Late-onset Hypogonadism: A Prospective, Fixed-dose, Placebo-uncontrolled, Open-label, Multicenter Study | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"박남철(부산대학교); 서주태(관동대학교); 문기학(영남대학교); 박광성(전남대학교); 박종관(전북대학교); 박현준(부산대학교)"
] | Efficacy and Safety of Testosterone Gel in Korean Men with Late-onset Hypogonadism: A Prospective, Fixed-dose, Placebo-uncontrolled, Open-label, Multicenter StudyNam Cheol Park, Ju Tae Seo*, Ki Hak Moon†, Kwangsung Park‡, Jong Kwan Park§ and Hyun Jun Park | 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001215780 | oai_dc | 혈청 전립선특이항원 4.0 ng/ml 이상인 환자에서 전립선암을 예측할 인자로 Delta Prostate Specific Antigen의 유용성 | Delta Prostate Specific Antigen (PSA) Helps to Predict Prostate Cancer in Men with Serum PSA Level above 4 ng/ml | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"박봉희(전북대학교); 박정선(전북대학교); 박경수(서남대학교); 박종관(전북대학교)"
] | Delta Prostate Specific Antigen (PSA) Helps to Predict Prostate Cancer in Men with Serum PSA Level above 4 ng/mlBong Hee Park*, Jeong Seon Park*, Kyung Soo Park† and Jong Kwan Park*,‡ | 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001215776 | oai_dc | 타다라필의 24주간 투여가 하부요로증상 및 발기부전에 미치는 영향 | Effects of Administration of Tadalafil for 24 Weeks on Lower Urinary Tract Symptoms and Erectile Dysfunction | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"최세민(경상대학교); 이승현(경상대학교); 제성욱(경상대학교); 감성철(경상대학교); 화정석(경상대학교); 정기현(경상대학교); 현재석(경상대학교)"
] | Effects of Administration of Tadalafil for 24 Weeks on Lower Urinary Tract Symptoms and Erectile DysfunctionSee Min Choi, Seung Hyun Lee, Sung Uk Jeh, Sung Chul Kam,Jeong Seok Hwa, Ky Hyun Chung and Jae Seog Hyun | 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001279225 | oai_dc | 스트레스에 의한 백서 음경조직의 Rho-kinase 및 Nitric Oxide Synthase의 발현 변화 | Change in Expression of Rho-kinase and Nitric Oxide Synthase in Penile Tissue of Rats Under Stress | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"김규현(이화여자대학교); 윤하나(이화여자대학교)"
] | Purpose: The autonomic nervous system (ANS) and stress hormones are important mediators in the stress response. The ANS controls the tone of corpus cavernosal smooth muscle. Clinically, it is not uncommon to develop erectile dysfunction as the sequelae of acute or chronic stress, with or without loss of libido. In this study, we investigated the effect of stress on the expression of mediators of penile corpus cavernosal smooth muscle relaxation and contraction.
Materials and methods: Forty-eight male Sprague-Dawley rats were used, with 8 rats in each group. They were divided into six groups; stress+10, stress+20, and stress+30, which were named after their duration (days) of exposure, and a control group for each stress group. The stress group was maintained under a scheduled stress condition, while the control group was provided a comfortable general environment. Penile tissues were sampled and expressions of Rho-kinase, inducible nitric oxide synthase (iNOS), endothelial NOS (eNOS) and neuronal NOS (nNOS) were measured and analyzed by Western blotting.
Results: Penile Rho-kinase expression was significantly increased in the stress groups compared with the control group (p<0.05), with a greater increase during longer stress. Expression of iNOS was increased in stress+30 group (p<0.05). Expression of eNOS, nNOS, and Rho-kinase were increased in stress+20, stress+30 group (p<0.05).
Conclusions: These results suggest that stress may alter penile corpus cavernosal smooth muscle relaxation by affecting mediators.
| 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001279239 | oai_dc | 소아에서 회음부 외상 후 발생한 고혈류성 음경지속발기증 | High-flow Priapism in a Child After Perineal Trauma | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"김대근(한양대학교); 윤영은(한양대학교); 이상봉(한양대학교); 손영우(한양대학교); 박충기(한양대학교); 최홍용(한양대학교); 문홍상(한양대학교)"
] | High flow priapism is a prolonged, non-painful penile erection unrelated to sexual stimulation after penile or perineal trauma. We report a case of high-flow priapism treated successfully with superselective embolization. An 8-year-old boy presented to our hospital 9 days after having been struck in the perineum during a bicycle accident. After the injury, the patient suffered a painless prolonged erection. High flow priapism was diagnosed by cavernosal blood gas analysis and penile duplex doppler ultrasonography. We identified the position of the fistula and pseudoaneurysm with angiography and embolized the lesions super-selectively with an autologous blood clot, gel foam, and a microcoil, bilaterally. After 2 superselective embolizations, the patient had detumescence. This case shows that bilateral arterio-cavernosal fistulas can be successfully treated with superselective arterial embolization.
| 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001279191 | oai_dc | Sildenafil이 생식능력에 미치는 영향 | The Effect of Sildenafil on Fertility | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"서주태(관동대학교)"
] | Sildenafil citrate, a cyclic monophosphosphate-specific type 5 phosphodiesterae inhibitor (PDE-I) widely used as first-line therapy for erectile dysfunction (ED). Since the approval of sildenafil in 1998, more than 40 million men worldwide have been successfully treated with PDE-I. As a result of this huge success, marketing strategies for PDE-Is have extended to include younger men, in particular who suffer from poor endometrial development and erectile dysfunction related to medical conditions such as diabetes and spinal cord injuries. The aim of this review is to investigate the effects of sildenafil citrate on endometrial thickness and seminal parameters in young, infertile patients.
| 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001279183 | oai_dc | 성욕의 이해: 남성과 여성 | Understanding the Sex Drive of Men and Women | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"윤가현(전남대학교)"
] | Human behaviors are related to either life or death instincts. A sexual instinct or sex drive is an indispensable
element to both procreation and recreation. Instead of enjoying sexual expression to the full, people
control or suppress the sexual expression only inside their conjugal relations as they were educated or
cultivated. However, the suppression of sexual gratification leads to various kinds of substitute gratification.
In other words, people want more sexual expression as a reaction against suppression. Due to suppression,
the strength of the sexual instinct probably varies in each individual. In the traditional society, the sexual
instinct is very powerful in men and comparatively weak in women. Both social constructionism and essentialism
are rival approaches to the gender differences, but Baumeister introduced four theories about
cultural suppression of female sexuality. According to him, most research findings fit the female conspiracy
theory a little better than the other theories. While Baumeister pointed out that a woman's sex
drive naturally fluctuates over the years, he proposed that the female drive is more malleable than the
male drive in response to socio-cultural and situational factors. | 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001279230 | oai_dc | 칼라도플러음낭초음파검사상 좌측 정계정맥류로 진단된 환자에서 양측 미세수술 정계정맥류절제술의 효과 | Effect of Microsurgical Bilateral Varicocelectomy on Patients with a Left Varicocele Diagnosed by Color Doppler Ultrasonography | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"최만수(전북대학교); 김상득(전북대학교); 박정선(전북대학교); 김명기(전북대학교); 박종관(전북대학교)"
] | Purpose: The objective of this study was to evaluate the accuracy of color Doppler ultrasonography (CDU) and to assess the effects of microsurgical bilateral varicocelectomy on patients diagnosed with a left varicocele by CDU.
Materials and Methods: 69 patients with varicocele were enrolled between March 2005 and May 2007. The patients were randomized into 2 groups: group I-preoperative bilateral varicoceles were diagnosed by color CDU, and group II-only a left varicocele was diagnosed by CDU. All patients underwent an inguinal microsurgical varicocelectomy bilaterally. Statistical analysis was performed by paired Student's t-test and one way ANOVA.
Results: Mean age of the patients was 27.5±7.9 years. After surgery, semen parameters were significantly improved in sperm number in group I (p=0.002) and semen volume in group II (p<0.005). At the time of surgery, we found that 16 (88.9%) of 18 patients had bilateral varicoceles in group II. The accuracy of CDU to diagnose varicoceles was not perfect.
Conclusions: The bilateral microsurgical varicocelectomy in patients with only a left varicocele diagnosed by CDU significantly increased their semen volume. Most (88.9%) patients diagnosed with a left varicocele actually had bilateral varicoceles. Therefore, microsurgical bilateral varicocelectomy may be appropriate for infertile men with a left varicocele diagnosed by CDU.
| 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001279231 | oai_dc | 불필요한 생검을 줄이기 위한 경직장초음파검사, 혈청 전립선특이항원과 전립선특이항원밀도의 임상적 유용성 | The Clinical Significance of Transrectal Ultrasonography, Prostate-specific Antigen and Prostate-specific Antigen Density for the Reduction of Unnecessary Biopsies | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"김현태(영남대학교); 송필현(영남대학교 의과대학 비뇨기과학교실); 문기학(영남대학교)"
] | Purpose: To establish criteria for the safe reduction of unnecessary biopsies, we compared transrectal ultrasonography (TRUS) findings, serum prostate-specific antigen (PSA), and PSA density (PSAD) in the decision criteria for the TRUS guided prostate biopsy (TRUS-Bx).
Materials & Methods: A total of 914 patients underwent TRUS-Bx due to elevated PSA and/or focal nodules on the TRUS. The patients were divided into the prostate cancer (n=286, 31.3%) and the non-prostate cancer groups (n=628, 68.7%). The sensitivity, specificity, and accuracy of TRUS, PSA, and PSAD were retrospectively evaluated, and the single criterion or the combinations of the criteria which can safely reduce the unnecessary biopsies without missing prostate cancer were investigated.
Results: The sensitivity, specificity and accuracy of TRUS, PSA (cut-off value, 4ng/ml) and PSAD (cut-off level, 0.20ng/ml/cc) were 75.9%/78.3%/53.8%, 33.0%/52.5%/73.7%, and 34.0%/42.9%/48.3%, respectively. At the cut-off level of PSAD (0.20 ng/ml/cc), 65.1% of unnecessary biopsies were spared but 132 cases (22.2%) of prostate cancer were detected. However a focal nodule was detected on TRUS in 120 cases (90.9%) and the remaining 12 cases (9.1%) had PSA above 10ng/ml. By the combinations of criteria (PSAD, TRUS and PSA), 27.7% of unnecessary biopsies were spared without missing cancer.
Conclusions: A short-interval follow-up seems to substitute for the prostate biopsy if PSAD is below 0.20ng/ml/cc without nodular lesions on TRUS and PSA value is below 10ng/ml.
| 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001279238 | oai_dc | 선천성 정낭형성부전증 | A Patient with Congenital Agenesis of the Seminal Vesicles | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"김경연(을지대학교); 사공혁(을지대학교); 정지훈(을지대학교 의과대학); 이종현(을지대학교 의과대학); 이승배(을지대학교); 김은탁(을지대학교); 김대경(을지대학교); 우승효(을지대학교)"
] | Congenital agenesis of the seminal vesicle is commonly associated with mullerian duct cysts and frequently combined with anomalies of the vas deferens or urinary tract. We report a case of a 29 year-old man with congenital agenesis of the seminal vesicle without any associated anomaly of the urogenital organs. He had infertility for 2 years and two semen analyses revealed azoospermia. There was no abnormal finding in physical examination of the testis, epididymis, or vas deferens. However, we could not locate the seminal vesicles in a transrectal ultrasound and computed tomography. We referred him to an infertility clinic for assisted reproductive technology.
| 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001279234 | oai_dc | 정계정맥류 환자에서 수술 후 정액지표의 변화: 복강경술식과 서혜부 접근 미세수술의 비교 | Changes in Semen Parameters After Varicocelectomy: a Comparative Study of the Laparoscopic and Microsurgical Inguinal Approach | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"길명철(포천중문의과대학교); 신찬욱(동아대학교); 조재욱(동아대학교); 김수동(동아대학교); 강도영(동아대학교); 정재일(인제대학교); 정세일(동아대학교)"
] | Purpose: The purpose of this study was to compare the surgical outcomes of two different surgical methods for varicocelectomy, and to assess the effects of varicocelectomy on semen parameters in subinfertile men.
Materials and Methods: This study included 63 patients with clinically palpable varicocele and abnormal semen parameters who underwent varicocelectomy. Thirty-three patients underwent laparoscopic varicocelectomy, and 30 received microsurgical inguinal varicocelectomy. Semen analyses were performed 5.3 months later, and compared with the pre-operative data.
Results: The mean age of patients was 32.1±1.3 years old. Comparison of the semen parameters between pre and post-varicocelectomy revealed significant improvement in the sperm count (p<0.05). In laparoscopic and microsurgical inguinal varicocelectomy, the sperm counts were increased from 16.2±4.3 to 30.6±7.5 and from 15.4±3.8 to 37.5±7.7, respectively. Sperm motility also tended to improve.
Conclusions: Varicocelectomy enhanced semen parameters after both laparoscopic and microsurgical methods. In subfertile men, early varicocelectomy is recommended.
| 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001279222 | oai_dc | 제2형 당뇨쥐의 음경에서 PDE5 아형의 발현양상 | Expression Changes of the Phosphodiesterase 5 isoform in the Penis of Type 2 Diabetic Rat | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"고경태(한림대학교); 김효종(한림대학교); 한영국(한림대학교); 심종백(한림대학교); 김성용(한림대학교); 김하영(한림대학교); 양대열(한림대학교)"
] | Purpose: To investigate the tissue distribution of PDE5 isoforms in type 2 diabetic rat penile tissues.
Materials and Methods: We prepared ten male Otsuka Long-Evans Tokushima Fatty (OLETF) rats, which develop NIDDM naturally, and ten control male Long-Evans Tokushima Fatty (LETO) rats. An oral glucose tolerance test confirmed diabetes development in OLETF rats at 26 weeks. At 42 weeks, we checked serum glucose, testosterone, triglyceride, insulin, and adiponectin before sacrifice. We performed semi-quantitative multiplex RT-PCR for rat PDE5, PDE5A1, and PDE5A2. Immunohistochemistry was performed using mouse monoclonal anti-cGB-PDE5 and anti-smooth muscle α-actin.
Rseults: OLETF rats were significantly more hyperglycemic, hypogonadal, hyperinsulinemic, hypercholesterolemic, hypertriglycemic, and had lower adiponectin levels than LETO rats. Levels of PDE5 mRNA were decreased in OLETF rats, but there were no changes in PDE5A1 or PDE5A2 mRNA levels.
Conclusion: Diabetes may contribute to decreased expression of PDE5 mRNA, but not PDE5A1 or PDE5A2, in rat penile tissue. Furthermore, serum free testosterone was decreased in diabetic rats. PDE5 has an important role in the development of diabetic erectile dysfunction, but it is not clear whether PDE5A1 and PDE5A2 gene have specific roles.
| 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001279205 | oai_dc | 코코아 추출물의 흰쥐 음경 해면체 이완에 미치는 영향 | Effect of Cocoa Extract on Tension of the Corpus Cavernosal Tissue in Rat | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"최세민(경상대학교); 서덕하(경상대학교); 이승현(경상대학교); 제성욱(경상대학교); 감성철(경상대학교); 정재훈(경상대학교); 화정석(경상대학교); 정기현(경상대학교); 현재석(경상대학교)"
] | Purpose: Cocoa has antihypertensive activity, improves cerebral blood flow, and is an antioxidant. We evaluated the effect of cocoa extract on penile erection using the relaxation of the corpus cavernosal tissue in rat.
Materials and methods: We used male 8-week-old Sprague-Dawley rats weighting 250-350 g divided into three groups: corpus cavernosal tissue with the endothelium (group 1), tissue without the endothelium (group 2), and endothelium pretreated with L-NAME (group 3). Changes in isometric tension were examined in an organ bath. Aortic tissues were divided into three groups and treated in similar experiments simultaneously.
Results: Cocoa extract dose-dependently relaxed corpus cavernosal tissue pre-contracted by phenylephrine (10-6). In group 1, cocoa extract (10-3g/ml) induced relaxation by 97±5% (mean±SD). The extract was still effective but less potent tissue without endothelium or pretreated with L-NAME (10-4M). Similar effects were seen in aortic rings.
Conclusion: Cocoa extract relaxes corpus cavernosal tissue in a dose-dependent manner via NOS and the endothelium. Cocoa extract may therefore be effective for improving erectile function.
| 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001279228 | oai_dc | 흰쥐 음경해면체신경 손상 모델에서 제대혈 유래 인간 중간엽 줄기세포 치료의 효과 | The Effect of Human Umbilical Cord Blood Derived Mesenchymal Stem Cell Therapy in Rat Model of Cavernosal Nerve Injury | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"최아람(가톨릭대학교); 김성대(가톨릭대학교); 손동완(가톨릭대학교); 김두배(가톨릭대학교); 김현우(가톨릭대학교); 조수연(가톨릭대학교); 조용현(가톨릭대학교); 김세웅(가톨릭대학교)"
] | Purpose: To find out the effect of transplanted umbilical cord blood derived human mesenchymal stem cells (hUCB- MSCs) in the rat model of bilateral cavernosal nerve injury (BCNX)
Materials and methods: Male Sprague Dawley rats were divided into three groups: Group I (7 rats, Control, Sham operation) had only bilateral cavernosal nerve crushing injury. PKH-26 fluorescent cell linker was labeled to hUCB- MSCs Group II (7 rats) had transplantation of hUCB- MSCs (3×105cells/50μl PBS) into MPG after BCNX. Group III (7 rats) had transplantation of hUCB- MSCs (3×105cells/50μl PBS) into the CC after BCNX. We detected the PKH-26 labeled MSCs in Group II, and III at four weeks after transplantation. Peak intracavernosal pressure (ICP) and ICP/mean arterial pressure (MAP) were recorded after pelvic nerve stimulation at 12 weeks after transplantation.
Results: PKH-26 labeled hUCB-MSCs were detected in MPG and CC of group II and III at four weeks after transplantation. The peak ICP was significantly higher in the Group II (69.6±5.9mmHg) and Group III (59.7±7.6mmHg) compared to Group I40.6±10.5mmHg) at 12 weeks after transplantation. The rates of ICP/MAP were significantly higher in Group II (32.2±6.4%) and Group III (57.8±4.9%) compared to Group I (49.5±2.9%) at 12 weeks after transplantation.
Conclusions: The intracavernosal and major pelvic ganglion transplantation of hUCB- MSCs improve erectile function in a rat model of neurogenic impotence.
| 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001170400 | oai_dc | 수술적 교정이 불가능한 무정자증의 진단과 치료 | Diagnosis and Treatment of Surgically Uncorrectable Azoospermia | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"서주태(서울대학교)"
] | Accurate diagnosis and evaluation of surgically uncorrectable azoospermia are essential for appropriate treatment and intervention. This article summarized the latest ideas and issues in male infertility. The state of art is reviewed, including diagnostic tools for azoospermic men, sperm retrieval techniques, as well as assisted reproductive technique currently issued. Coupled with sperm retrieval, intracytoplasmic sperm injection(ICSI) has dramatically changed the treatment of surgically uncorrectable azoospermia. Despite severely impaired spermatogenesis, men with the finding of focal spermatogenesis in the testis biopsy specimens have become candidates for treatment. These couples should not only be counseled regarding the possibility of passing infertility to the offspring but also informed that genetic abnormalities may exist. Microsurgical reconstruction remains the treatment of choice for men with reconstructable obstructive azoospermia. Sperm retrieval techniques performed with ICSI are highly effective for men in whom reconstruction is not feasible and with impaired spermatogenesis. | 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART000949585 | oai_dc | 경구용 복용제 Sildenafil Citrate의 음경해면체내주사로 인한 음경 농양 | Penile Abscess Caused by Intracavernous Injection of Sildenafil Citrate Oral Pill | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"백운기(영남대학교); 김지윤(영남대학교); 권상택(영남대학교); 문기학(영남대학교); 박동춘(영남대학교); 조재호(영남대학교)"
] | We report the successful treatment by percutaneous aspiration and antibiotics of a penile abscess in an elderly man attributed to misapplication of sildenafil citrate. The etiology, diagnosis, and management of penile abscess are discussed. | 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001170443 | oai_dc | 실데나필 투약으로 발기능 회복 이후의 투약 중단 원인 | Sildenafil Compliance after Restoration of Erectile Function | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"손환철(서울대학교); 신재욱(서울대학교); 임대정(서울대학교); 박관진(서울대학교); 김수웅(서울대학교); 백재승(서울대학교)"
] | Purpose: Regarding for erectile dysfunction(ED), Sildenafil has produced satisfactory clinical results. However, Some patient discontinue sildenafil treatment for a variety of reasons after successful restoration of erectile function. We investigated the reasons for such discontinuations of sildenafil after restoration of erectile function by sildenafil medication.
Materials and Methods: After sildenafil medication, one hundred fifty six patients whose score of erectile function domain of the 15-item International Index of Erectile Function(IIEF) increased to 26 or more, were included in this study. Six-months after the first sildenafil prescription, compliance to medication and the reason for discontinuity were reviewed by chart or surveyed by telephone.
Results: In 156 successfully treated patients, 54(34.6%) discontinued sildenafil medication. The 2 most common reasons for discontinuation were trouble in the partners' or patients' emotional readiness for restoration of sexual activity after long-term abstinence and fear of possible side effects.
Conclusions: After restoration of erectile function, many patients discontinued the use of sildenafil medication. The reasons for discontinuing the medication were primarily emotional or relationship-oriented issues. The counseling of both partners and education about the effects and side effects of the drugs are recommended to promote the successful recovery of sexual activity. | 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001170445 | oai_dc | 부산지역 남성에서 조루증의 유병률 및 의식조사 | Prevalence and Knowledge of Premature Ejaculation in the Area of Busan | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"박성우(부산대학교); 박현준(부산대학교); 박남철(부산대학교)"
] | Purpose: We investigated the prevalence of premature ejaculation and knowledge of the disease in young and middle-aged men in Busan.
Materials and Methods: The subjects were 500 men aged from 21 to 49 years(average 37.7 years) who had no history of erectile dysfunction and had a stable sexual partner. The numbers of responders in their third, fourth, and fifth decades were 36, 299, and 165, respectively. All interviews were performed by the same urologic resident. The questionnaire consisted of 10 questions in three domains covering the prevalence and severity of premature ejaculation, its influence on sexual life, and therapy.
Results: The overall prevalence of premature ejaculation was 41.0% (205/500), being highest in younger men (50.0% in the third decade [18/36], 45.8% in the fourth decade [137/299], and 30.3% in the fifth decade [50/165]). Men saying they “always or almost always” or “usually” had the condition accounted for 2.0% (10 men) of the total study population, being 0 in the third decade, 2.0% (6 men) in fourth decade and 2.4% (4 men) in fifth decade. The man himself and his sexual partner complained of more than moderate discomfort in 29 cases (14.1%) and 22 cases (10.7%), respectively. Only three men (1.4%) had received treatment for premature ejaculation, but the numbers of men who wished to try medical or surgical treatment were 32 (66.7%) and 16 (33.3%), respectively.
Conclusions: Although the prevalence of premature ejaculation is high in young and middle aged men in Busan, it has not been regarded as sexual dysfunction for the most part, and the treatment rate is low. We suggest that public education about the pathophysiology and management of premature ejaculation is required. | 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001170492 | oai_dc | 음경요도내 첨형콘딜로마의 Holmium:YAG 레이저와5-Flurouracil 병용치료 | Combination Therapy of Intraurethral Condyloma Acuminatumwith Holmium:YAG Laser and 5-Fluorouracil Instillation | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"김일환(인제대학교); 조인래(인제대학교); 이건철(인제대학교부속일산백병원); 전준성(인제대학교)"
] | Purpose: Condyloma acuminatum is a common sexually transmitted disease of the external genitalia and anus. Approximately 5% of patients demonstrate urethral involvement. Electrical fulguration or excision using a pediatric resectoscope has been used in the management of such lesions. Holmium(Ho):YAG laser, 5-FU(fluorouracil), or interferon may be helpful in eradicating them. We reviewed the results of intraurethral condyloma acuminatum treatment with Ho:YAG laser and 5-FU solution.
Materials and Methods: From January 2001 to July 2002, seven patients with intraurethral condylomata acuminata were enrolled in the study. The mean age of the subjects was 19.5(range 25～43) years. Under local anesthesia with 10% lidocaine spray and jelly, all of the intraurethral lesions were removed with the Ho:YAG laser followed by coverage with 10mL of 5% 5-FU solution. Intraurethral injection of 5-FU was performed weekly up to six times. Urethroscopy for detection of recurrence was done 3 months after initial laser therapy.
Results: Most patients had multiple intraurethral lesions. Six patients (86%) responded to initial therapy without local recurrence witha mean follow-up of 15.8 (range 9.1-23.2) months. One patient had a recurrence at 2 months.
Conclusions: We believe that the Ho:YAG laser plus 5% 5-FU solution is a useful option for the treatment of intraurethral condyloma acuminatum. | 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001170444 | oai_dc | 음경골절의 수술적 치료 시 장기합병증 발생의 위험요소 | Risk Factors for Development of Long-term Complicationsafter Surgical Repair of Penile Fracture | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"유달산(서울아산병원(울산대부설)); 홍범식(울산대학교); 박종연(울산대학교); 안태영(울산대학교)"
] | Purpose: The aim of this study was to review clinical features of penile fracture and to characterize risk factors for the development of long-term complications after its surgical correction.
Materials and Methods: We retrospectively reviewed the cases of 10 patients who underwent surgical therapy for penile fracture between June 1995 and September 2003. Patient age at presentation ranged from 17 to 54 years (mean 32 years). All patients underwent surgical therapy in an emergency setting. The time between the injury and surgery ranged from 7 to 240 hours (mean 44.5 hours). Radiologic work-up included penile ultrasonography for 9 patients and retrograde urethrography for patients suspected of having concomitant urethral injury. We investigated multiple clinical features to characterize risk factors relevant to the development of long-term complications. The mean follow-up was 36.5 month.
Results: Penile ultrasonography revealed defects in the tunica albuginea in seven patients, including six in whom the defect was identical to the injury site. At surgery, the size of the injury was between 3 mm and 50 mm. Two patients with concomitant urethral injury showed larger defects than those with an intact urethra. Long-term complications such as penile curvature and erectile dysfunction were found in two men with large defects involving the urethra and three with long lapses from injury to surgical correction.
Conclusions: Long-term complications after surgical therapy for penile fracture are likely to occur in patients with a large defect in the tunica albuginea involving the urethra or with delayed surgical correction. | 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART000949584 | oai_dc | 불임남성에서 방향화효소 억제제의 치료기준 | Appropriate Testosterone-to-Estradiol Ratios for AromataseInhibitorUsage in Oligoasthenospermic Men | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"이재석(성균관대학교); 박용석(성균관대학교); 이중식(성균관대학교); 서주태(성균관대학교)"
] | Purpose: We investigated whether oligospermic or asthenospermic men have decreased testosterone-to-estradiol (TE) ratios and whether this condition can be corrected with an oral aromatase inhibitor. We also determined the predictive value of pretreatment TE ratios for aromatase inhibitor efficacy in infertile men.
Materials and Methods: From June 2002 to December 2003, a total of 68 subfertile men with abnormal TE ratios were treated with 1 mg of anastrozole daily for 3 months. Changes in serum testosterone, serum estradiol, TE ratios, and semen parameters were evaluated 3 months after this therapy.
Results: Men treated with anastrozole had an increase in TE ratios (mean 0.2±0.7 [SE] versus 0.38±0.15; p＜0.001). Semen analysis before and during anastrozole treatment showed an increase in sperm concentration (48.96 versus 70.42 million/mL; p＜0.001) and motility (26.3 versus 33.2%; p＜0.005).
Conclusions: Men who are subfertile with lower TE ratios can be treated with an aromatase inhibitor with an increase in TE ratios that correlates with improved semen characteristics. We advise that an aromatase inhibitor be used in oligospermic or asthenospermic men if the TE ratio is below 0.2. | 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001170446 | oai_dc | 질조직에서 폐경상태에 따른 안드로겐 수용체의 변화 | Effect of Menopause on the Expression of Androgen Receptors in Human Vagina | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"전종현(이화여자대학교); 윤하나(이화여자대학교)"
] | Purpose: Many women complain of various pattern of sexual dysfunction after surgical or natural menopause. This study aimed to investigate the effect of menopause on the expression of androgen receptors in the human vagina and sexual functions.
Materials and Methods: The subjects were women aged from their 30's to 70's who required transvaginal surgery. Subjects were divided into three groups: premenopausal, postmenopausal without hormone replacement therapy, and postmenopausal with hormone replacement therapy. Tissues from the proximal and distal thirds of the vagina were collected during the operation. The expression of androgen receptors was examined using RT-PCR and immunohistochemical techniques.
Results: In tissue from the distal third of the vagina, androgen receptor expression decreased after menopause compared with the premenopausal group. In the hormone replacement group, androgen receptor expression was decreased compared with non-hormone replacement group. Androgen receptor expression correlated with sexual function independent of hormonal status.
Conclusions: Clinically, significant numbers of postmenopausal women show changes of sexual function. Androgen is thought to be one of the major factors controlling female sexual function. This study supports that the androgen receptor expression could be changed by the hormonal status and we should consider this change when managing sexual dysfunction in female. | 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001215771 | oai_dc | 젊은 한국 남성에서 혈중 테스토스테론, 성호르몬결합글로불린, 에스트라디올 및 황체형성호르몬의 일중변동 | Diurnal Rhythms of Serum Total Testosterone, Sex Hormone Binding Globulin, Estradiol and Luteinizing Hormone in Young Korean Men: a Circadian Study | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"유대선(을지대학교); 김은탁(을지대학교); 김경연(을지대학교); 우승효(을지대학교)"
] | Diurnal Rhythms of Serum Total Testosterone, Sex Hormone Binding Globulin, Estradiol and Luteinizing Hormone in Young Korean Men: a Circadian Study Dae Seon Yoo, Eun Tak Kim, Kyung Yeun Kim and Seung Hyo Woo | 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001215770 | oai_dc | 음경 보형물 삽입술의 합병증과 재수술의 원인 분석 | Analysis of Complications and Causes of Revision of Penile Prosthesis | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"전상봉(전북대학교); 정영범(전북대학교); 박영경(전북대학교); 박종관(전북대학교)"
] | Analysis of Complications and Causes of Revision of Penile ProsthesisSang Bong Jeon, Young Beom Jeong, Young Kyung Park and Jong Kwan Park | 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001215784 | oai_dc | 근치적 전립선적출술 후 조기 타다나필 투여가 발기능 회복에 미치는 영향 | Recovery of the Spontaneous Erections after Radical Prostatectomy with Early Tadalafil Treatment | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"송강현(울산대학교); 이정민(울산대학교); 유창희(울산대학교); 홍범식(울산대학교); 김청수(울산대학교); 안한종(울산대학교); 안태영(울산대학교)"
] | Recovery of the Spontaneous Erections after Radical Prostatectomy withEarly Tadalafil TreatmentKanghyon Song, Jung Min Lee, Chang Hee You, Bumsik Hong,Choung-Soo Kim, Hanjong Ahn and Tai Young Ahn | 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001215786 | oai_dc | 정계정맥류가 동반된 다고환증 | Polyorchidism with Varicocele | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"임화수(영남대학교); 김현태(영남대학교); 박동춘(영남대학교); 문기학(영남대학교)"
] | Polyorchidism with VaricoceleHwa Su Lim, Hyun Tae Kim, Tong Choon Park, Ki Hak Moon | 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001215774 | oai_dc | 노화 백서에서 음경해면체 내배아줄기세포 주입에 의한 발기능의 변화 | Effects of Intracavernosally Injected Embryonic Stem Cells in Aged Rat | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"정승일(전남대학교); 유광호(전남대학교); 윤철웅(전남대학교); 이현숙(전남대학교); 박광성(전남대학교); 안규윤(전남대학교); 한호재(서울대학교)"
] | Effects of Intracavernosally Injected Embryonic Stem Cells in Aged RatSeung Il Jung, Kwang Ho Ryu, Chul Woong Youn, Hyun-Suk Lee,Kwangsung Park, Kyu Youn Ahn* and Ho Jae Han† | 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001215785 | oai_dc | 용적이 큰 전립선비대증에서 경요도전립선절제술: 관혈적전립선적출술과의 비교 | Transurethral Resection of Prostate for Large Benign Prostatic Hyperplasia: a Comparative Study with Open Prostatectomy | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"이준녕(경북대학교); 예석준(경북대학교); 김재수(경북대학교); 유은상(경북대학교); 박윤규(경북대학교)"
] | Transurethral Resection of Prostate for Large Benign Prostatic Hyperplasia: a Comparative Study with Open ProstatectomyJun Nyung Lee, Seok Jun Ye, Jae Soo Kim, Eun Sang Yoo and Yoon Kyu Park | 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001215772 | oai_dc | 정계정맥류 치료를 위한 경피적 내정계정맥코일색전술의 초기치험 | Early Experience of Percutaneous Coil Embolization of Internal Spermatic Vein for the Treatment of Varicocele | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"허정식(제주대학교); 김승형(제주대학교); 김영주(제주대학교)"
] | Early Experience of Percutaneous Coil Embolization ofInternal Spermatic Vein for the Treatment of VaricoceleJung-Sik Huh, Seong Hyung Kim* and Young-Joo Kim | 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001215773 | oai_dc | 토끼 정낭 평활근 세포에 존재하는 포타슘 통로 활동도에 미치는 식물성 에스트로겐의 효과 | Effects of Phytoestrogen on Potassium Channel Activities of Smooth Muscle Cells of Rabbit Seminal Vesicle | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"최준(중앙대학교); 기세휘(중앙대학교); 김유찬(중앙대학교); 김태형(중앙대학교)"
] | Effects of Phytoestrogen on Potassium Channel Activities ofSmooth Muscle Cells of Rabbit Seminal Vesicle Jun Choi, Sae Hwai Ki, Yu Chan Kim* and Tae-Hyoung Kim* | 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001215497 | oai_dc | 대사증후군과 발기부전 | Metabolic Syndrome and Erectile Dysfunction | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"손환철(서울대학교)"
] | Metabolic Syndrome and Erectile DysfunctionHwancheol Son | 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001215494 | oai_dc | 한국 남성에서 남성갱년기 증후군의 인지도에 관한 조사 -40대 이상을 대상으로 한 연령별 설문 조사- | Attitude of Korean Males toward Late-Onset Hypogonadism: Survey of Males in Their 40s and Above | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"박민구(고려대학교); 이종(고려대학교); 강석호(고려대학교); 문두건(고려대학교); 김제종(고려대학교); 강승철(고려대학교); 이태원(고려대학교)"
] | =Attitude of Korean Males toward Late-Onset Hypogonadism:Survey of Males in Their 40s and AboveMin Gu Park, Seung Chul Kang, Tae Won Lee, Jong Lee, Seok Ho Kang, Du Geon Moon and Je Jong Kim | 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001215490 | oai_dc | 여성 성기능장애의 내과적 치료 | Medical Treatment of the Female Sexual Dysfunction | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"민권식(인제대학교)"
] | =Medical Treatment of the Female Sexual DysfunctionKweon-Sik Min | 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001215493 | oai_dc | 만성골반통증후군 환자에서 조루증의 유병률 | Prevalence of Premature Ejaculation in Chronic Pelvic Pain Syndrome | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"용득중(인제대학교); 이승언(인제대학교); 송현동(인제대학교); 오범석(인제대학교); 조성용(인제대학교); 전준성(인제대학교); 이건철(인제대학교부속일산백병원); 조인래(인제대학교)"
] | =Prevalence of Premature Ejaculation in Chronic Pelvic Pain SyndromeDeuk Jung Yong, Sung On Lee, Hyun Dong Song, Bum Seok Oh,Sung Yong Cho, Joon Seong Jeon, Keon Cheol Lee and In Rae Cho | 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001215492 | oai_dc | 흡연이 발기부전 환자의 음경혈류역동학적 검사결과에 미치는 영향 | The Effect of Smoking on Penile Hemodynamics in Erectile Dysfunction | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"박현준(부산대학교); 천원희(부산대학교); 정석근(부산대학교); 박남철(부산대학교)"
] | =The Effect of Smoking on Penile Hemodynamics in Erectile DysfunctionHyun Jun Park, Won Hee Chon, Suk Gun Chung and Nam Cheol Park | 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001215496 | oai_dc | 고환에 발생한 경계영역성 장액성 유두상 낭선종 | A Serous Papillary Cystadenoma of Borderline Malignancy in Testis | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"박현준(부산대학교); 박성우(부산대학교); 천원희(부산대학교); 정석근(부산대학교); 박남철(부산대학교)"
] | =A Serous Papillary Cystadenoma of Borderline Malignancy in TestisHyun Jun Park, Sung Woo Park, Won Hee Chon, Suk Gun Jung and Nam Cheol Park | 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001215495 | oai_dc | 국제전립선증상점수 한글 번역본의 타당성: 환자 작성과 의사 작성의 점수 비교 | Validation of Korean Version of International Prostate Symptom Score: a Comparison of Physician versus Self-administration | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"김정훈(중앙대학교); 김세철(중앙대학교)"
] | 기존의 국제전립선증상점수 한글번역본의 신빙성을 높이기 위해 타당도에 대한 재검증이 필요할 것으로 생각한다.결 론 | 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001215491 | oai_dc | 발기부전을 동반한 수면 무호흡 증후군 환자에서 수면다원검사지표의 의의 | The Meaning of Polysomnographic Indexes in Patients with Obstructive Sleep Apnea and Erectile Dysfunction | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"이상욱(한림대학교); 고경태(한림대학교); 심종백(한림대학교); 김성용(한림대학교); 김하영(한림대학교); 양대열(한림대학교); 이주헌(한림대학교)"
] | =The Meaning of Polysomnographic Indexes in Patients withObstructive Sleep Apnea and Erectile DysfunctionSang Wook Lee, Kyoung Tae Ko, Jong Baeg Shim, Sung Yong KimHayoung Kim, Dae Yul Yang and Ju Hun Lee* | 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001215485 | oai_dc | 제2형 당뇨 쥐 음경해면체 조직 내 Nitric Oxide Synthase Isoforms의 발현양상 | Penile Expression of Nitric Oxide Synthase Isoforms in the Type II Diabetic Rat | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"이정오(부산대학교); 박부경(부산대학교); 박현준(부산대학교); 박남철(부산대학교)"
] | =Penile Expression of Nitric Oxide Synthase Isoforms in the Type II Diabetic Rat Jeong Oh Lee*, Bu Kyung Park, Hyun Jun Park and Nam Cheol Park | 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001215486 | oai_dc | 발기부전 환자에서 음경해면체 내 발기유발제 반응에 따른 Sildenafil의 효과 예측 | Prediction of Sildenafil Response according to Intracavernosal Injection Test in Patients with Erectile Dysfunction | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"이정선(전남대학교); 정승일(전남대학교); 박광성(전남대학교)"
] | =Prediction of Sildenafil Response according to Intracavernosal InjectionTest in Patients with Erectile DysfunctionJeong Seon Lee, Seung Il Jung and Kwangsung Park | 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001215487 | oai_dc | 난소적출과 죽상경화증이 백서의 질 혈류에 미치는 영향 | Effects of Ovariectomy and Atherosclerosis on Rat Vaginal Blood Flow | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"박동수(서울대학교); 김성한(서울대학교); 백재승(서울대학교); 김수웅(서울대학교)"
] | =Effects of Ovariectomy and Atherosclerosis on Rat Vaginal Blood Flow Dong Soo Park, Sung Han Kim, Jae-Seung Paick and Soo Woong Kim | 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001215489 | oai_dc | 백서의 음경해면체에서 테스토스테론이 Transforming Growth Factor (TGF)-β1의 발현에 미치는 영향 | Effects of Testosterone on the Expression of Transforming Growth Factor (TGF)-β1 in Rat Penile Corpus Cavernosum | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"정승일(전남대학교); 이미나(전남대학교); 안규윤(전남대학교); 박광성(전남대학교)"
] | =Effects of Testosterone on the Expression of Transforming GrowthFactor (TGF)-β1 in Rat Penile Corpus CavernosumSeung Il Jung, Mi Na Lee, Kyuyoun Ahn* and Kwangsung Park | 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001215482 | oai_dc | 후기 발현 남성 성선기능저하증의 최신지견 | Recent Update on Late-onset Hypogonadism in Males | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"김제종(고려대학교); 문두건(고려대학교)"
] | =Recent Update on Late-onset Hypogonadism in Males Je Jong Kim and Du Geon Moon | 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001215484 | oai_dc | 키와 체중, 신체질량지수가 젊은 남성의 정계정맥류에 미치는 영향 | The Impact of Height, Weight and Body Mass Index(BMI) in Young Men with Varicoceles | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"유창승(국립경찰병원); 임종완(국립경찰병원); 설승훈(국립경찰병원); 장윤형(국립경찰병원); 박연원(국립경찰병원); 이진형(국립경찰병원); 민승기(국립경찰병원)"
] | =The Impact of Height, Weight and Body Mass Index(BMI) in Young Men with Varicoceles Changseung Liu, Jong Wan Im, Seung Hun Seol, Yun Hyung Jang,Yeon Won Park, Jinhyung Lee and Seung Ki Min | 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001215488 | oai_dc | 항산화제와 유전자치료의 병합요법: 혈관성 발기부전 백서모델에 미치는 영향 | Combination of Gene Therapy with Antioxidant Therapy in a Rat Model of Vasculogenic Erectile Dysfunction | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"박관진(원자력병원); 송상훈(서울대학교); 김수웅(서울대학교); 백재승(서울대학교)"
] | =Combination of Gene Therapy with Antioxidant Therapy in a Rat Model of Vasculogenic Erectile DysfunctionKwanjin Park, Sang Hoon Song*, Soo Woong Kim* and Jae-Seung Paick* | 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001215483 | oai_dc | 후기발현 생식샘저하증에서 경피용 테스토스테론(Testogel？)의 투여 효과: 혈중 테스토스테론의 농도 및 AMS 설문지에 근거한 증상점수의 변화 | The Efficacy of Transdermal Testosterone(Testogel？) in Late Onset Hypogonadism Patients: Changes in Serum Testosterone Level and Symptom Scores Based on Aging Males’ Symptoms Scale | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"배재현(고려대학교); 김노수(고려대학교); 김종욱(고려대학교); 박민구(고려대학교); 김명준(한림대학교); 문두건(고려대학교); 김제종(고려대학교)"
] | =The Efficacy of Transdermal Testosterone (Testogel ) in Late Onset Hypogonadism Patients: Changes in Serum Testosterone Level and Symptom Scores Based on Aging Males' Symptoms ScaleJae Hyun Bae, No Soo Kim, Jong Wook Kim, Min Goo ParkMyung Joon Kim, Du Geon Moon and Je Jong Kim | 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001170830 | oai_dc | 요도 내 이물 4례 | Foreign Body in the Urethra | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"박현준(부산대학교); 남종길(부산대학교); 김정만(부산대학교); 박남철(부산대학교)"
] | Most foreign bodies in the lower genitourinary tract are self-inserted through the urethra. A diagnosis is made by clinical history, physical examinations, and imaging studies of the patient. The best method of removing a urethral foreign bodydepends on the size and mobility of the object. When possible, endoscopic and minimallyinvasive techniques of removal should be used. However, surgical retrieval of a foreign body may be required. We report 4 cases of foreign bodies in the urethra with a brief literature review. | 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001170831 | oai_dc | 음경귀두부에 발생한 악성 흑색종 1례 | A Case of Primary Malignant Melanoma on the Glans Penis | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"정재훈(경상대학교); 감성철(경상대학교); 화정석(경상대학교); 정기현(경상대학교); 이정희(경상대학교); 박형철(경상대학교); 현재석(경상대학교)"
] | Malignant melanomas of the genitourinary tract are uncommon, accounting for less than 1% of all cases of melanoma and only a small percentage of penile carcinoma. In industrialized counties, penile cancer is an uncommon malignancy, with a reported annual incidence of 1 per 100,000 men. Malignant melanoma of the penis is a rare lesion and will be encountered infrequently during urological practice. Here in, we report a case of primary malignant melanoma of the penis and a brief review of the literature. | 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001170739 | oai_dc | 성체 백서에서 Ethane 1,2-Dimethane Sulfonate (EDS)가 고환 내 스테로이드 합성 관련 유전자 발현과 부고환 정자 수에 미치는 효과 | Effect of Ethane 1,2-Dimethane Sulfonate(EDS) on the Testicular Expressionof Steroidogenesis-related Genes and Epididymal Sperm Count in the Adult Rat | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"전윤(상명대학교); 김수웅(서울대학교); 백재승(서울대학교); 이성호(상명대학교)"
] | 비뇨기과학 | null | kci_detailed_000253.xml | ||||
ART001170780 | oai_dc | 제2형 당뇨쥐에서 음경해면체의 Hypoxia-inducible Factor-1α 및 Vascular Endothelial Growth Factor의 발현 | Expression of Hypoxia-inducible Factor-1α and Vascular Endothelial GrowthFactor in Corpus Cavernosum of the Type 2 Diabetes Mellitus Rat | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"이원기(한림대학교); 고경태(한림대학교); 이상욱(한림대학교); 서창덕(한림대학교); 김성용(한림대학교); 김하영(한림대학교); 양대열(한림대학교); 김두만(한림대학교)"
] | Purpose: The expression of hypoxia-inducible factor-1α(HIF-1α) and vascular endothelial growth factor(VEGF) has been known as important factor of vascular complications in diabetes mellitus. The penile tumescence has variable degree according to vascularity. The aims of this study were to investigate erectile function and cavernosal expression of HIF-1α and VEGF in Otsuka Long-Evans Tokushima Fatty(OLETF) rats, which develop NIDDM naturally.
Materials and Methods: Ten male OLETF rats and ten control male Long-Evans Tokushima Fatty(LETO) rats were included in this study. The development of diabetes mellitus for OLETF were defined by glucose tolerance test at 26 weeks. After 72 weeks, OLETF rats, LETO rats and ten twenty-week male Sprague-Dawley rats were studied. Intracavernosal pressure were measured after cavernous nerve stimulation. Immunohistochemical stain and Western blot analysis were done for HIF-1α and VEGF in corpus cavernosum.
Results: Cavernous nerve stimulation-induced mean intracavernosal pressure(mmHg) was significantly decreased in the OLETF group(21.6+/-6.7 mmHg) compared to LETO(32.8+/-16.0 mmHg) group and in the LETO group compared to Sprague-Dawley group(47.2+/-11.7 mmHg)(p＜0.05). With Western blot analysis, HIF-1α and VEGF expressions were higher in the OLETF group compared to other groups. With immunohistochemical stain, HIF-1α and VEGF were mainly expressed in corpus cavernosum and endothelium.
Conclusions: We propose that increased HIF-1α and VEGF expressions in OLETF rat penile tissue can be found at microvascular injury in corpus cavernosum and are presumed to be associated with vasculogenic erectile dysfunction. | 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART000970462 | oai_dc | 프라더 고환측정기와 음낭초음파를 이용한 고환용적 측정의 차이 | A Difference in Testicular Volumes Measured byPrader Orchidometer and Scrotal Ultrasound | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"곽경원(중앙대학교); 명순철(중앙대학교); 김태형(중앙대학교); 김세철(중앙대학교)"
] | Purpose: The aim of this study was to compare testicular volumes measured by Prader orchidometer and scrotal ultrasound.
Materials and Methods: The volumes of 467 adult male testes were measured by Prader orchidometer and scrotal ultrasound. The testicular volumes on ultrasound were calculated by the formula: length×width×height×0.71. The testicular volumes of the Prader orchidometer were divided into two groups: 15 ml or less, and over 15 ml. The two measurements were compared for each group.
Results: In the group with testicular volumes of 15 ml or less, the testicular volumes measured by orchidometer(13.29±1.94 ml) were significantly smaller than those measured by ultrasound(14.83±2.76 ml). In contrast, the group with over 15 ml did not show any significant difference in the volumes measured by orchidometer(21.21±2.58 ml) versusultrasound(20.77±4.26 ml). Mean paired differences of the testicular volumes between the orchidometer and ultrasound were 1.54±2.65 ml for the group with 15 ml or less and -0.44±3.38 ml for the group over15 ml these values are significantly different.
Conclusions: In cases of testicular volume of 15 ml or less measured by Prader orchidometer, scrotal ultrasound is necessary for an accurate measurement of the volume. | 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001170781 | oai_dc | 정계정맥류 수술 전후의 정액 소견과 호르몬 양상의 비교 | Pre- and Post-operative Assessment of Semen and HormoneStatus in Patients with Varicocele | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"장상웅(전북대학교); 김명기(전북대학교); 박종관(전북대학교)"
] | Purpose: We evaluated the result of varicocelectomy on semen and hormone status to assess the effect of the operation.
Materials and Methods: Between March 2001 and January 2004, 63 men with varicocele underwent microsurgical inguinal varicocelectomy. Based on their chief complaint, they were classified into two groups: scrotal pain group (n=17) and infertility group(n=14). They were checked by semen analysis and hormone status(LH, FSH, testosterone) and GnRH stimulation test before the operation and 3 months after the operation.
Results: The mean ages of the pain and infertility groups were 24.8±5.2 years and 32.6±2.9 years, respectively. The results of postoperative semen analyses were improved in both groups and in all items. In the pain group, postoperative LH, FSH, and testosterone levels were increased, and the ratio of changes of FSH and testosterone after GnRH stimulation were decreased significantly after operation. In the infertility group, post-operative hormone levels were increased, and the ratio of changes of hormone level after GnRH stimulation were decreased, but, the results were not statistically significant.
Conclusions: The results of semen analyses were improved significantly after varicocelectomy. Post-operative hormone levels were increased, and the ratio of changes of hormone level after GnRH stimulation were decreased. We think that the pre- and post-operative semen analyses, hormone level, and GnRH stimulation test could be useful in assessing the success of varicocelectomy. | 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART000970461 | oai_dc | 전립선염의 진단과 치료 | Evaluation and Treatment of Patients with Prostatitis | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"조인래(인제대학교)"
] | Prostatitis is a common syndrome that is confusing and frustrating for urologists. Chronic prostatitis/chronic pelvic pain syndrome(CP/CPPS) is the most common form of prostatitis. The etiology of CP/CPPS is unknown, but possibilities include infectious, autoimmune, neurological and psychiatric causes. Clinical, laboratory, and imaging evaluations for the patient presenting prostatitis can be categorized as basic or mandatory evaluations, further or recommended evaluations, and optional evaluations in selected patients. Evaluation can aid in diagnosis and follow-up of the patient's response to therapy. Treatment for CP/CPPS is empiric and limited by a lack of randomized, placebo-controlled clinical trials. Antimicrobials are commonly used to treat patients with prostatitis. Other commonly used drugs include α-adrenoceptor antagonists, anti-inflammatory drugs, tricyclic antidepressants, and anticholinergic agents. Also, minimally invasive procedures are considered in patients with CP/CPPS. Although much progress has been made in therapy, there is no distinct treatment for patients with CP/CPPS. It is possible to treat intractable patients with ‘care' not ‘cure'. | 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001170738 | oai_dc | 음경 복합 도플러 초음파를 이용한 발기부전 진단: Trimix 해면체 내 주사법과 Vardenafil 복용법의 비교 | Evaluation of Erectile Dysfunction by Penile Duplex Doppler Ultrasonography:Trimix Intracavernosal Injection Versus Vardenafil Oral Medication | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"황인상(전남대학교); 박광성(전남대학교)"
] | Purpose: The aims of this study were to evaluate whether vardenafil, a phosphodiesterase type 5 inhibitor, may be used as a substitute for intracavernosal injection when assessing erectile dysfunction using penile duplex Doppler ultrasonography.
Materials and Methods: A total of 21 patients with erectile dysfunction underwent penile duplex Doppler ultrasonography after intracavernosal injection of 0.2 ml trimix. Each patient also underwent penile duplex Doppler ultrasonography after a 10-mg oral dose of vardenafil with audio-visual sexual stimulation. There was 1 week interval between each study. In both studies, peak systolic velocity, end-diastolic velocity, and resistive index were measured. Then ultrasonographic diagnoses of erectile dysfunction were classified as arteriogenic, veno-occlusive, and mixed-type.
Results: Doppler ultrasonography with trimix intracavernosal injection identified 8(38.1%), 1(4.8%), 10(47.6%), and 2(9.5%) patients with arteriogenic, veno-occlusive, mixed-type, and non-vasculogenic impotence, respectively. After vardenafil oral medication, 10(47.6%), 1(4.8%), and 10(47.6%) patients demonstrated arteriogenic, veno-occlusive, and mixed-type impotence, respectively. There was a difference in diagnosis in 23.8% of cases.
Conclusions: Vardenafil oral administration with audio-visual sexual stimulation showed a similar hemodynamic result compared to trimix intracavernosal injection during penile duplex Doppler ultrasonography. However, there were some differences. These results suggest that vardenafil oral medication may be used as a substitute for intracavernosal injection when assessing erectile dysfunction using penile duplex Doppler ultrasonography. However, further investigation is needed. | 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001170782 | oai_dc | 중증 하부요로증상이 있는 남성갱년기 환자에서 알파차단제와 남성호르몬 치료 병합요법 | Combination Therapy of Androgen Replacement and Alpha-blockersin Patients with PADAM and Severe LUTS | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"홍준혁(울산대학교); 안태영(울산대학교)"
] | Purpose: Severe LUTS (lower urinary tract symptoms) have been considered to be a contraindication to ART (androgen replacement therapy) in PADAM (partial androgen deficiency in aging male) patients. But increasing numbers of patients presenting with PADAM have also LUTS due to the enlarged prostate. We investigated the effect of ART to the prostate in whom LUTS are controlled with alpha-blockers.
Materials and Methods: Of those patients who visited our clinic for PADAM symptoms and had decreased serum levels of total testosterone(＜2.8 ng/ml, Biodata, Italy), men with severe voiding symptoms(IPSS 20～35) were recruited. Oral androgen(testosterone undecanoate 160 mg/day) and doxazosin(2～4 mg/day) were administered. IPSS score, prostate volume by TRUS, and serum PSA were assessed.
Results: A total of 25 patients were enrolled. Mean patient age was 63.5(51～89) years and median duration of follow-up was 754 days. Initial prostate volume by TRUS was 34.50±10.22 ml. Voiding symptoms evaluated by IPSS score improved significantly from 24.12±2.54 to 14.64±6.01(p＜0.01). Serum PSA level showed no significant change from 1.20±0.54 ng/ml to 1.30±1.05 ng/ml.
Conclusions: PADAM patients with severe voiding symptoms could be treated with a combination of androgen therapy and alpha-blockers. Further studies with longer follow-up would be required to confirm our results. | 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001170829 | oai_dc | 만성 골반통증후군에서 통증, 배뇨증상 및 삶의 질에 대한 체외자기장치료의 효과 | The Effect of Extracorporeal Magnetic Innervation Therapy on Pain,Urination and Quality of Life in Chronic Pelvic Pain Syndrome | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"박해영(한양대학교); 문홍상(한양대학교)"
] | Purpose: Chronic pelvic pain syndrome(CPPS) is the most common category of the chronic prostatitis. CPPS is a poorly defined, multifactorial condition characterized by pelvic pain and voiding symptoms. The effectiveness of extracorporeal magnetic innervation(ExMI) therapy was evaluated in patients with CPPS.
Materials and Methods: From July 2003 to December 2004, 28 men who were diagnosed with CPPS who were refractory to medication underwent ExMI therapy for 2 visits weekly for 8 weeks. The patients completed the National Institute of Health Chronic Prostatitis Symptom Index(NIH-CPSI) and a maximal flow rate index.
Results: Significant decreases occured in NIH-CPSI pain(9.7 to 8.3, p＜0.05), NIH-CPSI urination(4.4 to 3.9, p＜0.05), NIH-CPSI quality of life 8.7 to 7.7, p＜0.05), and total NIH-CPSI(22.8 to 19.9, p＜0.05) scores after treatment. There was an insignificant decrease in the maximal flow rate(21.5 to 21.4, p＞0.05) score after treatment.
Conclusions: ExMI therapy effectively improves the symptoms of CPPS. ExMI therapy appears to be a safe and effective treatment in improving both the symptoms and the quality of life of men with CPPS refractory to conventional treatment. A larger controlled study is required to confirm these results. | 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001206068 | oai_dc | 백서에서 테스토스테론이 음경해면체내 주입된 배아줄기세포에 미치는 영향 | Effects of Testosterone on the Intracavernosally Injected Embryonic Stem Cells in Rat | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"오경진(전남대학교); 이현숙(전남대학교); 이미나(전남대학교); 민정준(전남대학교); 한호재(서울대학교); 박광성(전남대학교)"
] | =Effects of Testosterone on the Intracavernosally Injected Embryonic Stem Cells in Rat Kyung Jin Oh, Hyun-Suk Lee, Mi Na Lee, Jung Joon Min*, Ho Jae Han† and Kwangsung Park | 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001206069 | oai_dc | 전립선에 발생한 아밀로이드증 | Amyloidosis of the Prostate | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"김재수(경북대학교); 조덕현(경북대학교); 김현태(경북대학교); 유은상(경북대학교); 박윤규(경북대학교)"
] | =Amyloidosis of the ProstateJae Soo Kim, Deok Hyun Cho, Hyun Tae Kim, Eun Sang Yoo and Yoon Kyu Park | 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001023760 | oai_dc | 한국 젊은 남성의 발기부전 유병률과 위험요인에 대한 인터넷 조사 연구 | The Prevalence and Risk Factors for Erectile Dysfunction in Korean Young Men: a Web-based Survey | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"김미진(서울대학교); 신건희(서울대학교); 류석태(서울대학교); 고성민(서울대학교); 김희진(서울대학교); 송상훈(서울대학교); 성수정(성균관대학교); 주관중(성균관대학교); 김수웅(서울대학교); 백재승(서울대학교); 손환철(서울대학교)"
] | =The Prevalence and Risk Factors for Erectile Dysfunction in Korean Young Men:a Web-based SurveyMijin Kim*, Geon Hee Shin*, Suktae Ryoo*, Sungmin Ko*, Heejin Kim*, Sang Hoon Song†, Sujeong Seong‡, Kwan Joong Joo§, Soo Woong Kim†, Jae-Seung Paick† and Hwancheol Son†,∥ | 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001023759 | oai_dc | 뇌졸중 환자의 성기능과 뇌 병변과의 관계 | The Changes of Male Sexual Dysfunction after Stroke; Correlations of Brain Lesions and Sexual Function | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"정재훈(경상대학교); 권오영(경상대학교); 현재석(경상대학교)"
] | =The Changes of Male Sexual Dysfunction after Stroke;Correlations of Brain Lesions and Sexual FunctionJae-Hun Jung, Oh-Young Kwon* and Jae-Seog Hyun | 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001023763 | oai_dc | 흰쥐의 뇌실주위신경핵에서 Dxytocin 발현에 미치는 유형 5 Phosphodiesterase 억제제(Vardenafil)의 영향에 대한 기초연구 | Preliminary Study of Effects of Type V Phosphodiesterase nhibitor(Vardenafil) on Oxytocin Expression in the Rat Paraventricular Nucleus | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"주관중(성균관대학교); 박홍재(성균관대학교); 김계환(성균관대학교)"
] | =Preliminary Study of Effects of Type V Phosphodiesterase Inhibitor (Vardenafil) on Oxytocin Expression in the Rat Paraventricular Nucleus Kwan Joong Joo, Heung Jae Park and Khae Hawn Kim | 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001023761 | oai_dc | 발기능 저하를 보이는 환자에서 이중 맹검법을 이용한 산삼배양근 추출물의 효과에 대한 초기 경험 | Double-blind, Placebo-controlled, Multi-center Study for Therapeutic Effects of Mountain Panax Ginseng C.A. Meyer Extract in Men with Erectile Dysfunction: a Preliminary Report | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"김홍식(충남대학교); 우승효(을지대학교); 조성환(충북대학교); 한은주(충북대학교); 윤내영(산본제일병원); 이형래(산본제일병원)"
] | =Double-blind, Placebo-controlled, Multi-center Study for Therapeutic Effects of Mountain Panax Ginseng C.A. Meyer Extract in Men with ErectileDysfunction: a Preliminary Report Hong Sik Kim*, Seung Hyo Woo†, Shunghwan Jo‡, Eun-Joo Hahn§,Nae Young Youn∥ and Hyung-Lae Lee | 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001023762 | oai_dc | 정자형성저하증 환자에서 신선 고환조직 정자와 동결 고환조직정자를 이용한 수정률과 배발달률 및 임신율의 결과 | Fertilization, Embryonic Development, and Pregnancy Rate using Fresh and Frozen Testicular Sperm in Hypospermatogenesis | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"박용석(성균관대학교); 이선희(성균관대학교); 한상철(성균관대학교); 최수진(성균관대학교); 전진현(을지대학교); 궁미경(성균관대학교); 서주태(성균관대학교)"
] | =Fertilization, Embryonic Development, and Pregnancy Rate using Fresh and Frozen Testicular Sperm in Hypospermatogenesis Yong-Seog Park, Sun-Hee Lee, Sang Chul Han, Su Jin Choi, Jin Hyun Jun, Mi Kyoung Koong* and Ju Tae Seo†Laboratory of Reproductive Biology and Infertility, Departments of *Obstetrics and Gynecology,†Urology, Cheil General Hospital & Women's Healthcare Center, Sungkyunkwan University School of Medicine, Seoul, Korea | 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001023758 | oai_dc | 발기부전의 유전자치료 | Gene Therapy for Erectile Dysfunction | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"류지간(인하대학교); 서준규(인하대학교)"
] | 현재까지의 연구결과로 미루어 볼 때, 유전자치료는 향후 발기부전 치료법에 있어 중요한 위치를 차지할 것이다. 유전자치료는 기존의 경구용 PDE5 억제제 또는 주사용 혈관확장제와 비교해서 여러 장점이 있다. 첫째, 장기, 즉 음경해면체를 구조적, 기능적으로 회복할 수 있다. 둘째, 단 1회 투여로 장기간의 치료효과를 기대할 수 있다. 셋째, 성관계 시 계획이 필요 없어 성행위의 자발성을 회복할 수 있다. 넷째, 발기력이 완전히 정상수준으로 회복되지 못한 경우에도, 부분적으로 개선된 음경해면체 기능으로 인해서 기존의 경구용 PDE5 억제제와 병용하면 효과를 얻을 수 있다. 이와 같은 많은 장점에도 불구하고 임상적으로 사용될 수 있는 유전자치료제의 개발이 부진했던 것은 치료효과가 완전하고 장기적인 치료유전자의 개발이 미흡했기 때문이다. 최근, 임상시험 중인 포타슘통로 유전자, 전임상연구 중인 혈관생성 유전자, Rho-kinase 억제 유전자 등에서 이러한 문제를 해결할 수 있을 것으로 기대한다. 악성종양과 같은 치명적인 질환과 달리 발기부전에서 유전자치료가 실제 환자에게 적용되기 위해서는, 좀 더 높은 수준의 안전성이 필요하다. 실제로 기존의 아데노바이러스 벡터 또는 AAV 벡터를 발기부전 환자에게 사용하기는 어려울 것이다. 오랜 기간 높은 효율로 유전자를 발현할 수 있고, 면역반응을 최소화하는 새로운 바이러스 벡터의 개발, 생분해성 중합체 (biodegradable polymer)를 이용한 좀 더 효율적인 비바이러스 벡터의 개발, 그리고 음경해면체에서 특정 유전자의 발현을 증가시킬 수 있는 촉진자의 개발이 필요하다. 발기부전 분야에서 유전자치료의 임상적 성공은, 다른 여러 종류의 심혈관질환 및 평활근 질환에서도 새로운 치료의 길을 열어줄 것이다. | 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001170643 | oai_dc | 음경해면체 내 IGF-1 주사요법이 노화 백서의발기력에 미치는 영향 | Intracavernosal Injection of Insulin Like Growth Factor-1 ImprovesErectile Function in Aging Rat | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"안규윤(전남대학교); 박광성(전남대학교); 오경진(전남대학교); 김민경(전남대학교); 이송은(전남대학교); 이영익(한국생명공학연구원); 류수방(전남대학교)"
] | Purpose: Insulin like growth factor-1(IGF-1) is known to promote the proliferation and migration of penile cavernous smooth muscle cells in rat. The purpose of this study was to investigate whether IGF-1 could restore erectile function in the aging rat.
Materials and Methods: Male Sprague-Dawley rats were divided into two groups: young(4～5 months; n=10) and old(24 months; n=30). The old group was further divided into vehicle only(phosphate buffered saline plus 0.1% bovine serum albumin; n=10) and IGF-1 treatment(100 μg; n=20) groups. Half of the IGF-1 dose(50 μg) was injected on the first day, and half was injected on the third day. After 2 and 4 weeks of treatment, erectile function was evaluated by hemodynamic study, and corpus cavernosal histology was examined by histomorphometric analysis.
Results: The ratio of peak intracavernosal pressure to systemic arterial blood pressure was significantly lower in the vehicle-only old rats(63.1±8.5%) compared to young rats(74.6±3.2%)(p=0.016). However, after 4 weeks of treatment, the ratio was significantly increased in the IGF-1 treatment group(77.2±7.0%) compared to the vehicle-only group(p＜0.05). The percentage of smooth muscle was significantly lower in the vehicle-only old rats(12.8±2.2%) compared to young rats(17.8±3.7%)(p=0.047), whereas, it was significantly increased in the IGF-1 treatment group (19.4±3.3%) compared to the vehicle-only group(p=0.014).
Conclusions: Intracavernosal injection of IGF-1 in the old rats resulted in increased intracavernosal pressure and higher percentage of cavernosal smooth muscle. These results suggest that intracavernosal injection of IGF-1 appears to restore smooth muscle integrity and improve erectile function in aged rats. | 비뇨기과학 | null | kci_detailed_000254.xml | |||
ART000949679 | oai_dc | 개 교상에 의한 고환파열 | Testicular Rupture Due to Dog Bites | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"박현준(부산대학교); 김성권(부산대학교); 남종길(부산대학교); 이창렬(부산대학교); 박남철(부산대학교)"
] | Dog bites are common in many countries and the most common type of animal bites. Despite the high rates, genital trauma, especially scrotal trauma, caused by dog bite is rare, with few cases reported in the literature. We report the successful treatment of testicular rupture due to dog bite. Treatment consisted of orchiectomy with surgical debriment and antibiotics. The diagnosis and management of scrotal injury caused by dog bite are discussed. | 비뇨기과학 | null | kci_detailed_000254.xml | |||
ART001170693 | oai_dc | 마취된 흰쥐에서 약물에 의한 중추성 발기유발효과 | Drug Induced Cerebral Proerectile Effect in Anesthethetized Rats | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"박현준(부산대학교); 남종길(부산대학교); 박남철(부산대학교)"
] | Purpose: To examine the centrally elicited erectile effects of α-MSH, oxytocin, prostagladin E1, and anabolic steroids after intracerebroventricular administration.
Materials and Methods: We used anesthetized male Sprague-Dawley rats. After intracerebroventricular administration of normal saline (NS), α-melanocyte stimulating hormone (α-MSH), oxytocin acetate (OT), prostaglandin E1 (PGE1), methylprednisolone (MP), testosterone enanthate (TE) or 17β-estradiol (E2) under stereotaxis, the intracavernosal pressure (ICP), systolic femoral artery pressure (FAP), heart rate (HR), time to first response, duration, and number of erectile responses and adverse reactions were evaluated for 60 minutes. To show whether erections were centrally elicited, the above criteria were re-evaluated after a bilateral pelvic neurotomy and bilateral orchiectomy.
Results: A cerebral proerectile effect was elicited only by α-MSH and OT with no significant changes of FAP or HR. With PGE1, significant changes in FAP and HR were observed. The ICP/FAP ratio was highest (0.49±0.03) with α-MSH. The mean time latency was shortest with OT (20.6±5.6 min). The mean duration was longest in α-MSH (11.6±8.7 min). The number of responses was highest with OT (3.6±0.7). Adverse reactions, such as stretching, yawning and ejaculation, were simultaneously observed during increases in ICP. In the cases of a bilateral pelvic neurotomy or bilateral orchiectomy, these elicited erectile responses disappeared.
Conclusions: α-MSH had the most potent proerectile effect compared to OT and PGE1 as assessed by highest intracavernosal pressure as well as duration of erectile response. The results suggest that testosterone and the pelvic nerve were essential for the central proerectile response. | 비뇨기과학 | null | kci_detailed_000254.xml | |||
ART000949678 | oai_dc | 구연산 실데나필(Sildenafil Citrate)의안전성 및 유효성에 대한 연구: 시판 후 조사 | Postmarketing Assessment of Sildenafil in Terms of Safety and Efficacy | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"백재승(서울대학교)"
] | Purpose: The main purpose of postmarketing surveillance of drugs is to better characterize the safety profile of drug therapy in routine clinical practice. Another goal is to confirm the effectiveness of the tested drugs in clinical practice. A postmarketing survey was undertaken to monitor the safety and efficacy of sildenafil citrate (SC) as a treatment for erectile dysfunction in Korean men.
Materials and Methods: This 6-week, observational, open-label, uncontrolled, longitudinal, prospective study was conducted by 50 general hospitals across Korea. Men aged ≥20 years with erectile dysfunction who, in their physicians' opinion, should be treated with SC were enrolled for this study. To evaluate efficacy, the global efficacy assessment questionnaire(GEAQ) was administered before, and 2～4 weeks and 4～6 weeks following the initiation of SC therapy. Information regarding adverse drug reaction(ADR)s was collected on case-report forms designed for each visit and analyzed by the scientific committee of the study.
Results: A total of 935 patients were enrolled, and 818 patients were assessable for safety. A total of 561 patients satisfied the requirements for efficacy analysis. Seventy-two patients(8.8%) experienced 99 ADRs over the 6 weeks. The most common ADRs were facial flushing(5.7%) and headache(2.0%). Eight patients discontinued the medication due to ADR. In response to the global efficacy assessment question, 91.4% of patients reported that SC improved their erectile function. Unlike the results of clinical trials, 67.2% of the population studied required 50 mg sildenafil to attain satisfactory erection.
Conclusions: In this postmarketing surveillance study of Korean patients with erectile dysfunction treated in routine clinical practice, SC showed a satisfactory tolerability and efficacy profile that was consistent with that seen in randomized, controlled trials. | 비뇨기과학 | null | kci_detailed_000254.xml | |||
ART001170695 | oai_dc | 전립선 비대증 환자에서 알파 1 교감신경수용체 차단제Tamsulosin이 성기능에 미치는 영향 | Effects of Alpha 1 Adrenoceptor Antagonist Tamsulosin on SexualFunction in Patients with Benign Prostatic Hyperplasia | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"박종관(전북대학교); 김청수(울산대학교); 박철희(계명대학교); 이정구(고려대학교); 정병하(연세대학교); 홍성준(연세대학교)"
] | Purpose: We evaluated the effectiveness of alpha 1 adrenoceptor antagonist tamsulosin on erectile function in the treatment of the patients with benign prostatic hyperplasia(BPH).
Materials and Methods: We recruited 268 patients who had BPH with lower urinary tract symptoms in the period of June 2003 to September 2003. The study utilized an open-label approach. Patients were evaluated by physical examination, transrectal ultrasonography(TRUS), serum prostate specific antigen(PSA), uroflowmetry, international prostatic symptom score(IPSS), quality of life(QOL) assessment, voiding diary for 3 days, brief international index of erectile function(IIEF)-7 score, and the global efficacy assessment questionnaire(GEAQ)-2. All evaluations were performed before medication, and again at 4 and 12 weeks of treatment. The patients suspected to have prostatic carcinoma based on the digital rectal examination and/or PSA level above 4 ng/ml underwent transrectal ultrasonography guided biopsy of the prostate. The patients found to have prostate cancer were not included in the study.
Results: A total of 165 patients completed the study. Total IIEF scores did not change significantly. Question 10 of IIEF was significantly different between 4 and 12 weeks. There was a statistically significant difference in GEAQ-2 between 4 and 12 weeks of medication. Ejaculation volume decreased 14% and 22% at 4 and 12 weeks, respectively. However, orgasmic function significantly improved between 4 and 12 weeks.
Conclusions: In patients with BPH, tamsulosin therapy improved sexual and orgasmic function, although it decreased ejaculation volume. We need a longer follow-up period and more patients to establish the effects of tamsulosin on erectile function in the patients with BPH. | 비뇨기과학 | null | kci_detailed_000254.xml | |||
ART000949726 | oai_dc | 젊은 여성의 성생활과 성인식에 대한 인터넷 조사 연구 | Internet Survey on the Sexual Life and Attitude of Sexual Life of Young Women | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"손환철(서울대학교); 박용현(서울대학교); 홍성규(서울대학교); 김수웅(서울대학교); 백재승(서울대학교); 이현아(서울대학교); 배광범(서울대학교); 전혜원(서울대학교)"
] | Purpose: To obtain basic information for studies of female sexual dysfunction, we investigated the sexual activities and attitudes of young Korean women.
Materials and Methods: We conducted a questionnaire survey via the Internet. From July 2004 to August 2004, we sent e-mail to 43,000 women who registered with an internet research company. The recipients of the e-mail were asked to join our study if they had stable sexual activities more than once a month for the most recent 6 months.
Results: A total of 508 subjects completed the questionnaire, a response rate of 24.7%. Among 423 questionnaires analyzed, 176 women were single and 247 were married. The mean frequency of coitus per month was 5.5±3.9. About 40% of the women had experienced masturbation, and 112 women(26.5%) had masturbated regularly, even though they had stable sexual activities with their partner(s). Among the 423 subjects, 349 had no plan to have a baby; however, only 287 subjects(67.8%) had used a contraceptive method(s). Among those who used contraceptive methods, 183 subjects(63.8%) used methods with low success rates, such as menstrual timing or extra-vaginal ejaculation. Most of the women answered that they have a positive attitude toward sex (3.4±0.8 point on a 5 point scale) and their sex life has great importance in their life.
Conclusions: Via an Internet survey, we investigated the sexual life and attitudes of young Korean women. An Internet survey requires less manpower, a shorter study period, and less research funds than classical survey methods such as mail or interview surveys. The study results obtained will be useful as basic data for studies of female sexual function in Korean women. | 비뇨기과학 | null | kci_detailed_000254.xml | |||
ART001170644 | oai_dc | 백서의 음경해면체에서 Dimethylarginine Dimethylaminohydrolase의 존재와 이들의 기능변화가 발기능에 미치는 영향 | Putative Asymmetric Dimethyl Arginine - Dimethylarginine Dimethylaminohydrolase Pathway in Rat Penile Tissue: A Biochemical and Functional Study | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"신재욱(서울대학교); 박관진(서울대학교); 김수웅(서울대학교); 백재승(서울대학교)"
] | Purpose: Asymmetrical NG,NG-dimethyl-L-arginine(ADMA) is an endogenous inhibitor of nitric oxide synthase (NOS) and is metabolized by NG,NG-dimethylarginine dimethylaminohydrolase(DDAH). Although the ADMA-DDAH axis is widely distributed in human as well as rat tissues, the existence and the pathophysiologic role of DDAH in erectile function has not yet been studied. Therefore, we sought to demonstrate the presence of DDAH and investigate the relative amounts of two types of DDAH in rat cavernosal tissue. Also, we studied the effect of DDAH inhibition on erectile function in rats.
Materials and Methods: We developed cDNA probes for rat DDAH 1 and 2 by specific reverse-transcriptase mediated polymerase chain reaction(PCR). The presence and relative distribution of both types of DDAH gene expression were assessed using real time PCR and immunoblotting. To inhibit cavernosal DDAH, a specific inhibitor of DDAH(S-2-amino-4(3-methylguadino)butanoic acid) was administered to anesthesized rats via intracavernosal injection. The corporal level of ADMA was measured by high performance liquid chromatography. Erectile function was assessed by comparing the results of cavernous electrostimulation before and 30 minutes after drug administration.
Results: The presence of DDAH is demonstrated by the results of real time PCR and immunoblotting. Although both types were identified in rat penile tissue, type 2 was dominant. Intracavernosal injection of DDAH inhibitor markedly elevated the level of ADMA (0.86 nmol/g wet wt pretreatment to 4.25 nmol/g wet wt post-treatment) and resulted in a significant decrease of ICP/MAP in the anesthesized rats during cavernous electrostimulation.
Conclusions: Our study is the first to demonstrate the existence of the ADMA-DDAH axis in the rat penile tissue. Since inhibition of DDAH impeded erectile function, alteration of this axis may be another cause of erectile dysfunction. | 비뇨기과학 | null | kci_detailed_000254.xml | |||
ART001170694 | oai_dc | 혈정액증에서의 Finasteride 효과 | Effects of Finasteride on Hemospermia | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"조인래(인제대학교); 이건철(인제대학교부속일산백병원); 전준성(인제대학교); 박석산(인제대학교)"
] | Purpose: We evaluated the therapeutic efficacy of finasteride in the treatment of hemospermia, especially in prostatitis-related hemospermia.
Materials and Methods: Among the patients who visited our urologic department due to hemospermia from Jan 2000 to Oct 2003, 46 patients enrolled in the study. Semen analysis, expressed prostatic secretion, and transrectal ultrasonography were performed for all patients, and we determined whether or not the hemospermia was caused by inflammatory chronic non-bacterial prostatitis. We sorted all the subjects into 2 groups by the use of finasteride or not. We sub-divided the 2 groups by the presence or absence of prostatitis. In each of the 4 groups, the results were compared. Results were also recalculated after excluding sonographically abnormal cases.
Results: In the 35 finasteride-treated patients, the prostatitis group showed a 75%(12/16) success rate whereas the non-prostatitis group showed 31.6%(6/19) success. This difference was statistically significant(p=0.01). In the 11 non-finasteride patients, there was no difference in success rate between the prostatitis group(57.1%) and non-prostatitis group(50.0%). After excluding 15 sonographically abnormal patients, the finasteride-prostatitis group showed an 80%(8/10) success rate whereas the non-prostatitis group showed a 25%(3/12) success rate.
Conclusions: Finasteride treatment in hemospermia was more successful in prostatitis than non-prostatitis patients. Efficacy was more prominent after excluding sonographically abnormal cases. Finasteride could be an useful agent in the treatment of prostatitis-related hemospermia. More extensive study is needed. | 비뇨기과학 | null | kci_detailed_000254.xml | |||
ART000949677 | oai_dc | 전립선 비대증과 알파 교감신경 수용체 차단제 | Benign Prostatic Hyperplasia and Alpha Adrenoceptor Blockers | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"박종관(전북대학교)"
] | Benign prostatic hyperplasia(BPH) is the most common disease affecting middle-aged and elderly men. The symptoms of BPH are brought on by enlargement of the prostate by epithelial and smooth muscle cells, urinary obstruction, increased outflow resistance, and unstable detrusor muscle response to obstruction.
There are three alpha-1 adrenoceptor(AR) subtypes in prostatic stromal tissue: alpha-1A AR, alpha-1B AR, and alpha-1D AR. Alpha-1 AR blockers relax the prostatic smooth muscle and bladder neck leading to pressure decreases in the bladder and urethra. This treatment improves urinary flow, because 98% of alpha-1 AR is located in the prostatic stroma, and alpha-1 AR is increased in smooth muscle of the enlarged prostate. A selective alpha-1A AR blocker improves obstructive symptoms than irritative symptoms because of the characteristics and distribution of alpha-1A AR and alpha-1D AR in the genito-urinary tract. A combined therapy with selective alpha-1A and alpha-1D AR blockers may improve both voiding and filling symptoms. | 비뇨기과학 | null | kci_detailed_000254.xml | |||
ART001170493 | oai_dc | 남성갱년기와 호르몬 보충요법 | PADAM(Partial Androgen Deficiency in the Aging Male)and Hormone Replacement Therapy | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"김제종(고려대학교)"
] | 비뇨기과학 | null | kci_detailed_000254.xml | ||||
ART001170594 | oai_dc | 정상 정액에서 Percoll Gradient, PureSperm Gradient, Swim-up방법을 이용한 정자 분리법의 효용성 비교 | Efficiency of Percoll Gradient, PureSperm Gradient, andSwim-up Separation Techniques in Normal Semen Samples | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"이선희(성균관대학교); 송상진(성균관대학교); 한상철(성균관대학교); 변혜경(성균관대학교); 서주태(성균관대학교); 박용석(성균관대학교)"
] | Purpose: The aim of this study was to compare sperm concentration, motility, viability, and morphology using Percoll gradient, PureSperm gradient, and the swim-up method in normal semen samples.
Materials and Methods: Ten normal semen samples were divided into three fractions. Motile sperm were isolated with Percoll gradient, PureSperm gradient, and swim-up method. Sperm concentration, motility, viability, and morphology were determined before and after separation.
Results: The sperm concentrations were not significantly different among the three methods: Percoll gradient(34.3±9.4x106/ml), PureSperm gradient(37.6±16.6x106/ml), and swim-up(27.3±6.4x106/ml). There was no significant difference in sperm motility among the three methods: Percoll gradient(93.5±1.6%), PureSperm gradient(92.7±4.4%), and swim-up(95.7±2.7%). When sperm motility was measured 24 hr later, the results were similar among the three methods: Percoll gradient(81.7±15.5%), PureSperm gradient(84.3±12.2%), and swim-up(89.4±5.1%). Sperm viability and morphology were slightly higher in swim-up method than the other methods, but the differences were not statistically significant. Sperm viability datas were: Percoll gradient(85.5±5.5%), PureSperm gradient(85.6±3.7%), and swim-up(88.6±6.6%). Morphology datas were: Percoll gradient(82.0±10.7%), PureSperm gradient(73.9±9.3%), and swim-up(83.7±8.5%).
Conclusions: The swim-up method resulted in viability and morphology that were slightly higher than the other methods. However, all methods were useful for sperm preparation in normal semen samples. | 비뇨기과학 | null | kci_detailed_000254.xml | |||
ART001170541 | oai_dc | 디지털진동각측정기 MMD-1000A？를 이용한 음경 진동각 역치측정 | Measurement of penile sensitivity by digital virometer MMD-1000A | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"박현준(부산대학교); 김정만(부산대학교); 박부경(부산대학교); 박남철(부산대학교)"
] | Purpose: The measurement of penile sensitivity is a noninvasive and economical screening method to detect various neurologic disorders including premature ejaculation. We measured the normal range of penile sensitivity using a conventional analogue vibrometer and a new type of digital vibrometer and compared the clinical utility of the two instruments.
Materials and Methods: The vibration threshold of 50 males who had normal erectile function and ejaculation was measured 3 times with both an analogue and a digital vibrometer. The sites of measurement included the plantar side of the 2nd finger, a distal site on the calf, the penile shaft, and glans. The confidence interval was analyzed by the Kernel density estimation method.
Results: The ranges measured by the digital vibrometer were narrower than those measured by the analogue instrument. The normal ranges in the 90% confidence interval by the digital vibrometer were 1.03～2.16, 2.49～10.13, 1.54～3.41, 1.61～3.53, 1.91～3.80, 1.55～4.03 Hz/mv in finger tip, calf, right penile shaft, left penile shaft, right glans penis, and left glans penis, respectively. The normal ranges in the 95% confidence interval by digital vibrometer were 1.07～2.15, 3.23～9.50, 1.58～3.33, 1.65～3.48, 1.93～3.38, 1.83～3.73 Hz/mv in finger tip, calf, right penile shaft, left penile shaft, right glans penis, and left glans penis, respectively. The results from the digital vibrometer were more consistent than those by the analogue vibrometer.
Conclusions: The digital vibrometer, MMD-1000AⓇ can substitute for the analogue type and has the advantages of greater convenience and more precise measurement of penile sensitivity. | 비뇨기과학 | null | kci_detailed_000254.xml | |||
ART001170593 | oai_dc | 저혈류성 음경지속발기증 모델에서 음경해면체내의Heme Oxygenase-1의 발현과 활성도의 변화 | Change of Expression and Activity of Heme Oxygenase-1 in RatCorpus Cavernosum during Lowflow Priapism | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"김우진(경상대학교); 정행기(경상대학교); 정재훈(경상대학교); 감성철(경상대학교); 화정석(경상대학교); 현재석(경상대학교)"
] | Purpose: The inducible isoform of heme oxygenase(HO), HO-1, responds to hypoxia. HO-1 regulates vascular smooth muscle tone through carbon monoxide production. To investigate the possible role of HO-1 in low-flow priapism, we examined the expression and activity of HO-1 in artificially induced veno-occlusive priapism in rat.
Materials and Methods: Fourteen male Sprague Dawley rats were divided into 2 groups with 7 rats each. In the first group, low-flow priapism was induced using a vacuum-constriction device and a constriction rubber band; in the second group, low-flow priapism was induced using papaverine. We measured the expression level and activity of HO-1 in penile tissues after time periods of 0(control), 2, 3, 4, 8, 12, 24, and 48 hours. At the same time, the expression levels of i-NOS, e-NOS, and β-actin(control) in penile tissues were also measured.
Results: In both groups, expression of HO-1 and HO-1 enzyme activities in penile tissue significantly increased in a time dependent fashion(p＜0.01). However, there was no difference in the expression of i-NOS and e-NOS in both groups at any time period.
Conclusions: HO-1 was induced over time in rats with artificially induced veno-occlusive priapism. Induction of HO-1 may play a protective role against hypoxic injury, but may also play an important role in the vicious cycle observed for low flow priapism. Increasing induction of HO-1 against hypoxic injury in a prolonged erectile state promotes sustained dilatation of corporal smooth muscle, and this may aggravate low-flow priapism. | 비뇨기과학 | null | kci_detailed_000254.xml | |||
ART001170540 | oai_dc | 성기능장애 환자에서 HMD(Head Mounted Displayer)의3차원 입체 영상을 이용한 시청각 자극 검사의 유용성 | Diagnostic Utility of 3-Dimensional Head Mounted Display in Audiovisual Sexual Stimulation | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"송필현(영남대학교); 문기학(영남대학교); 박동춘(영남대학교)"
] | Purpose: This study evaluated the diagnostic utility of a 3-Dimensional head mounted display(HMD) in audiovisual sexual stimulation(AVSS).
Materials and Methods: A total of 45 men were included in this study: 15 healthy, 15 patients diagnosed with organic impotence, and 15 patients with psychogenic impotence. The NEVA(Nocturnal Electrobioimpedance Volumetric Assessment) system was performed during AVSS with both the 3-D HMD and a conventional monitor. In this study, normal erection was defined as a change in penile blood volume of more than 200% over the baseline for more than 5 minutes. After AVSS, each subject rated his sexual drive as grade I(poor), II(moderate), or III (good).
Results: Use of the conventional monitor produced a normal state in 8 men: 5 healthy volunteers(33%) and 3 patients with psychogenic impotence(20%). Use of the 3-D HMD produced a normal state in 23 men: 12 healthy volunteers(80%) and 11 patients with psychogenic impotence(73%). In the healthy volunteers and psychogenic impotence group, the duration of erectile events and percent of volume increase from baseline increased significantly more with 3-D HMD than with the conventional monitor. Compared to results using the conventional monitor, the subjects' sexual drive with 3-D HMD was also significantly increased(p＜0.05).
Conclusions: AVSS with 3-D HMD improves the recording of physiological erectile response and may be a valuable tool in making the correct diagnosis of erectile dysfunction. | 비뇨기과학 | null | kci_detailed_000254.xml | |||
ART000949676 | oai_dc | 여성 성적 스트레스 척도의 한글판 개발 및 표준화 연구 | Validity and Reliability of Korean Version of the Female Sexual Distress Scale (FSDS) | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"한창수(고려대학교); 김현철(고려대학교); 강석호(고려대학교); 문두건(고려대학교); 김제종(고려대학교); 최주연(고려대학교)"
] | Purpose: The Female Sexual Distress Scale(FSDS) was developed to measure sexually-related personal distress in women. We performed this study to assess the reliability and validity of FSDS-Korean version in Korean women.
Materials and Methods: The original 20-item FSDS was translated into Korean. One-hundred four healthy, married women were recruited and given the survey. A second survey was done two weeks later for test-retest reliability. Validity, internal consistency reliability, and test-retest reliability were evaluated.
Results: The test-retest coefficient of stability over a 2-week period was 0.99(p＜0.01). The 20 items of the FSDS have good internal consistency, with an alpha of 0.96. The FSDS discriminated between women with and without sexually related distress(t=-7.34, p＜0.01). The optimal cut-off score was 20(sensitivity 71.4%, specificity 92.2%).
Conclusions: The Korean version of FSDS might be a useful tool to screen for sexually distressed women in Korea. | 비뇨기과학 | null | kci_detailed_000254.xml | |||
ART001170494 | oai_dc | 음경해면체내 자가주사요법시 조루증 치료용국소마취제 사전도포의 통증경감효과 | Pain Relief by Lidocaine Solution Applied Prior to Intracavernosal Injection Therapy | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"박현준(부산대학교); 박성우(부산대학교); 박부경(부산대학교); 박남철(부산대학교)"
] | Purpose: Though intracevernosal injection(ICI) has been widely used to treat erectile dysfunction, its use has been restricted by injection-induced pain. We evaluated pain relief and sexual satisfaction following application of lidocaine solution prior to ICI.
Materials and Methods: Prospectively, 10 erectile dysfunction patients were given standard ICI treatment 5 times for 4 weeks and then ICI preceded by lidocaine 5 times for 4 weeks. Patients were asked to evaluate ICI-induced pain by the International Pain Scale System, erectile function by the International Index of Erectile Function-5(IIEF-5), sexual satisfaction by Global Assessment Questions(GAQ), and intravaginal ejaculatory latency time. We used Trimix (StandroⓇ) and 9.6% lidocaine solution(E.L.T solutionⓇ) designed to treat premature ejaculation.
Results: ICI-induced pain, rated by the International Pain Scale, was significantly reduced from 2.56±0.50 to 1.64±0.69 by the use of lidocaine before ICI(p＜0.05). Intravaginal ejaculatory latency time was significantly prolonged from 15.5±3.69 minutes to 19.2±2.94 minutes by the use of lidocaine before ICI(p＜0.05). Sexual satisfaction improved from 70% to 90% by the use of lidocaine before ICI. However, IIEF-5 scores were not significantly increased by the use of lidocaine(p＞0.05).
Conclusions: Application of lidocaine solution prior to ICI decreased ICI-induced pain and increased ejaculatory latency. Therefore, application of lidocaine solution can be a possible assistant method for ICI treatment. | 비뇨기과학 | null | kci_detailed_000254.xml | |||
ART001170542 | oai_dc | 거세된 쥐의 음경조직에서 Hypoxia inducible Factor-1a의 발현증가 | Increased Expression of Hypoxia-Inducible Factor-1α in Castrated Rat Penile Tissue | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"양대열(한림대학교); 이원기(한림대학교); 김기욱(한림대학교); 서창덕(한림대학교); 이영구(한림대학교); 김하영(한림대학교); 김성용(한림대학교); 박흥원(한림대학교); 조성진(한림대학교)"
] | Purpose: Hypoxia-inducible factor 1(HIF-1) is a transcriptional activator of genes whose products are involved in systemic, local, and cellular responses to hypoxia. We investigated the effect of androgen deprivation on the expression of HIF-1α and related proteins in the penile corpus cavernosum of castrated rat.
Materials and Methods: Thirty adult male Sprague-Dawley rats(250～350 gm) were divided into 3 groups of 10 each: sham operation(group 1), bilateral orchiectomy(group 2), and bilateral orchiectomy plus hormone replacement(group 3). Testosterone propionate(2 mg/day for 4 weeks) was used for hormone replacement. At 4 weeks after surgery, serum testosterone and erythropoietin were measured, and the expression of HIF-1α and VEGF were examined by immunohistochemical staining and Western blot of corpus cavernosum.
Results: There was no significant change in serum erythropoietin among the three groups. HIF-1α and VEGF immuno-positive cells were dense in vascular endothelium and cavernosal smooth muscle and showed more intense staining in the orchiectomy group compared with the control and sham operation groups. The amount of HIF-1α and VEGF proteins detected by Western blot were also increased in the orchiectomy group compared with the control and sham operation groups.
Conclusions: These results suggest that increased HIF-1α expression in the penile tissue of castrated rat results from adaptive responses to hypoxia, and testosterone deprivation may contribute to hypoxic injury in the cavernosal microenvironment. | 비뇨기과학 | null | kci_detailed_000254.xml |
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