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ART001581048 | oai_dc | Role of Phosphodiesterase Type 5 Inhibitor on Benign Prostatic Hyperplasia/Lower Urinary Tract Symptoms | Role of Phosphodiesterase Type 5 Inhibitor on Benign Prostatic Hyperplasia/Lower Urinary Tract Symptoms | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"Sang Deuk Kim(Chonbuk National University); 박종관(전북대학교)"
] | There is strong evidence from multiple epidemiological studies that benign prostate hyperplasia (BPH) induced lower urinary tract symptoms (LUTS) are correlated with erectile dysfunction (ED). Although a direct causal relationship is not established yet, four pathophysiological mechanisms can explain the relationship. These include alteration in activity of nitric oxide (NO)-cyclic GMP signal pathway, autonomic hyperactivity, increased Rho kinase/Rho A pathway and pelvic atherosclerosis. Androgens have been suggested to have an important role in the maintenance of the functional and structural integrity of the urinary tract. Sexual function should be assessed and discussed with the patient when choosing the appropriate management strategy for LUTS, as well as when evaluating the patient’s response to treatment. Multiple large clinical trials have shown an improvement in LUTS after phosphodiesterase-5 (PDE5)-inhibitor treatment. Sildenafil is a pioneer of this clinical trial and appears to improve both erectile function and LUTS in subjects with ED. Basically PDE5 I with long half life is an appropriate candidate, therefore tadalafil and undenafil had been used to evaluate both diseases. Placebo-controlled trials of tadalafil showed improvement of LUTS secondary to BPH, but none of the studies showed a significant effect on urodynamic measures. PDE5 Is, such as sildenafil and tadalafil, increase the concentration of cGMP in plasma and smooth muscle, facilitating erection of the penis, relaxation of the bladder neck and prostate and subsequent bladder emptying. And theses PDE5 Is increase cAMP and cGMP levels and are more highly distributed in the prostate than plasma. These findings may help in the assessment of the feasibility of using PDE5 Is to concurrently treat both LUTS and ED. | 비뇨기과학 | null | kci_detailed_000252.xml | |||
ART001581082 | oai_dc | 폐쇄성 무정자증의 원인 및 정관부고환문합술을 이용한 수술적 교정 가능성 | Causes of Obstructive Azoospermia and Outcome of Microsurgical Reconstruction | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"박세환(관동대학교); 서주태(관동대학교); 조대기(관동대학교); 이중식(관동대학교)"
] | Purpose: To define the causes of obstructive azoospermia (OA) and evaluate the possibility and efficacy of microsurgical correction.
Materials and Methods: Sixty-seven patients diagnosed as OA with normal spermatogenesis preoperatively and initially planned to microsurgical vasoepididymostomy from December 2003 and November 2009 were retrospectively analyzed. Causes of OA were analyzed and patency rate and pregnancy outcomes of their female partners were measured.
Results: Thirty-one patients (46.3%) could not correct their OA because of obstruction of the distal vas deferens, epididymal atrophy and/or hypotrophy and vasal injury due to previous surgery. Among the 36 patients undergone microsurgical vasoepididymostomy (mean age of patients and their female partners were 32.9 and 31.3 years, respectively), 32 patients (88.9%) were corrected bilaterally and 4 patients (11.1%) unilaterally. The overall patency rate was 17 patients (47.2%); being 15 and 2 patients for bilateral and unilateral procedure, respectively. Among the 17 patients regained the patency after surgery, except 3 cases without followed up, 6 cases achieved natural pregnancy and also 6 cases achieved the pregnancy using the assisted reproduction.
Conclusions: According to the affected point of reproductive tract, not all men with obstructive azoospermia were candidates for microsurgical reconstruction. However, reasonable outcomes were achieved in the microsurgical reconstruction cases and it should be primary therapeutic method in obstructive azoospermia. For those in whom reconstruction is not a viable option, surgical methods for sperm retrieval are available to have their own biological children. | 비뇨기과학 | null | kci_detailed_000252.xml | |||
ART001581066 | oai_dc | The Effect of Cyanidin-3-O-β-d-glucopyranoside on the Penile Erection and Corpus Cavernosum in a Rat Model of Diabetic Erectile Dysfunction | The Effect of Cyanidin-3-O-β-d-glucopyranoside on the Penile Erection and Corpus Cavernosum in a Rat Model of Diabetic Erectile Dysfunction | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"하유신(가톨릭대학교); 김세웅(가톨릭대학교); 고준성(가톨릭대학교); Jang Chun Woo(The Catholic University of Korea); Suk Ju Kim(The Catholic University of Korea); Su Jin Kim(The Catholic University of Korea); Hoon Jang(The Catholic University of Korea); 윤병일(가톨릭대학교); Seong Yeon Hwang(Korea Bio Medical Science Institute)"
] | Purpose: The aim of this study was to evaluate Cyanidin-3-O-β-d-glucopyranoside on improvement and protection for erectile function.
Materials and Methods: Sprague-Dawley rats (12wks old) were divided into three groups (n=12 in each): normal control, diabetes (DM), and diabetes with Cyanidin-3-O-β-d-glucopyranoside (C3G) concentration materials treatment (DM＋C3G). DM and DM＋C3G group received a single injection of streptozotocin (50 mg/kg), and 4 wk after induction of diabetes, DM＋C3G group were treated with daily C3G (10 mg/kg) dissolved in water for 8 wk. After 12 wk of streptozotocin injections, rats in each group underwent intracavernosal pressure measurement (ICP) and then the corporal tissues were sampled.
Results: DM group showed markedly lower erectile parameters than those in the control group, whereas rats in the DM＋C3G group showed improved erectile function by minimizing corporal apoptosis.
Conclusions: The current study is the first to suggest that Cyanidin-3-O-β-d-glucopyranoside may have a potency to improve and protect erectile function in a rat model of diabetic erectile dysfunction. | 비뇨기과학 | null | kci_detailed_000252.xml | |||
ART001581060 | oai_dc | Differential Expression of Proteins Related with Penile Apoptosis in a Rat after Cavernous Nerve Resection | Differential Expression of Proteins Related with Penile Apoptosis in a Rat after Cavernous Nerve Resection | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"양상국(건국대학교); 김보경(건국대학교); Chang Kwan Lee(Konkuk University); 정홍(건국대학교); 김홍섭(건국대학교); 류지간(인하대학교); 원경종(건국대학교); 박승화(건국대학교); 이환명(호서대학교)"
] | Purpose: The mechanism including changes of proteome within cavernosal tissue after cavernous nerve injury were not evaluated. We performed proteomics and functional analysis to identify proteins of penile corpus cavernosum whose expression was or was not altered by cavernous nerve resection (CNR).
Materials and Methods: Using 8-week-old male WKY rats, sham and CNR operation under microscope were performed. After 8 weeks, penile tissues of sham and CNR group were harvested. We used 2-DE and MALDI-TOF/TOF (AB 4700) to identify of differently expressed penile proteins. 2-DE gels were stained with silver nitrate and the gels were analyzed with PDQuest.
Results: We isolated more than 950 proteins on silver-stained gels of whole protein extracts from normal rat penile corpus cavernous. Of these proteins, 48 prominent proteins were identified using MALDI-TOF/TOF. Protein characterization revealed that the most prominent penile corpus cavernous proteins were those with antioxidant, chaperone, or cytoskeletal structure. Moreover, 11 proteins having levels elevated by CNR were annexin proteins, endoplasmic reticulum protein 29, glutathione s-transferase w-1, and others. In addition, Rho-GDP dissociation inhibitor (RhoGDI), a regulator of Rho proteins, was also increased in CNR rats compared with sham-operated control rats.
Conclusions: The apoptotic signals observed in penile tissues was greatly increased in CNR rats than in sham-operated rats. These results suggest that RhoGDI is one of the proteins regulated by CNR in penile smooth muscle strips, and has a crucial role in the early stage of penile apoptosis. | 비뇨기과학 | null | kci_detailed_000252.xml | |||
ART001581053 | oai_dc | Basic Principles of Laser for Prostate Surgery | Basic Principles of Laser for Prostate Surgery | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"김진욱(고려대학교); 문두건(고려대학교)"
] | Recent advances in laser technology have provided a varied arsenal for endoscopic treatment of benign prostatic hyperplasia. Laser is a collimated coherent radiation of photons generated by stimulated emission of gain media, allowing transfer of selective, controlled and focused energy to the targeted tissue. The application of laser to prostate surgery developed hand-in-hand with refinements to the equipment. Earlier lasers were low powered modalities with no significant tissue selectivity, aimed at thermal coagulation and resulted in significant side effects and recurrence. Since then, prostate lasers have developed towards a more high-powered and selective modality that allowed complete ablation of the tissue with fewer complications. Fiber technology has also developed to allow efficient and safe transfer of a continuously increasing energy output. It is important for the surgeon to understand these fundamental principles of laser and prostate surgery, not only to select the proper tools, but also to properly implement the technique as well. | 비뇨기과학 | null | kci_detailed_000252.xml | |||
ART001581089 | oai_dc | 술 전 5-알파환원효소억제제의 투여가 120W Greenlight^(TM) HPS 레이저를 이용한 광선택적 전립선기화술에 미치는 영향 | The Effect of 5-alpha Reductase Inhibitors on the Efficacy of Photoselective Vaporization of the Prostate with 120 W GreenLight HPS Laser | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"박현준(부산대학교); 박남철(부산대학교); 김현우(부산대학교); 김태남(부산대학교)"
] | Purpose: To evaluate the effect of preoperative 5-alpha reductase inhibitor (ARI) administration on the operative results of photoselective vaporization of prostate with 120W GreenLight HPS laser.
Materials and Methods: Data were collected from 98 benign prostatic hyperplasia (BPH) patients who underwent transurethral electrovaporization of prostate by 120W Greenlight HPS laser between Jan. 2010 and Dec. 2010. We compared the time of operation, the energy required in lasering, postoperative maximum uroflow velocity, change in residual urine volume and complications between 5-ARI administrating group and control group.
Results: 56 patients administrated 5-ARI at least 3 months before surgery. 30 and 26 patients administrated finasteride and dutasteride, respectively. Mean follow up period was 4.1±1.8 months. Mean age of the subjects and mean prostate volume were not different. Mean change of postoperative hemoglobin, lasing time and energy required in lasering were greater in 5-ARI administrating group. There were 3 and 1 cases of acute urinary retension in 5-ARI administrating group and control group, respectively.
Conclusions: The mean change of hemoglobin and mean energy required in lasering were greater and mean lasing time was longer in the patients who administrated 5-ARI before photoselective vaporization of prostate by 120W Greenlight HPS laser. Further investigation and extensive study will be needed to confirm these results. | 비뇨기과학 | null | kci_detailed_000252.xml | |||
ART001581088 | oai_dc | Effect of PDE5 Inhibitor in Nonsurgical Management of Peyronie’s Disease: Preliminary Study | Effect of PDE5 Inhibitor in Nonsurgical Management of Peyronie’s Disease: Preliminary Study | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"Byeong Kuk Ham(Korea University); 문두건(고려대학교); 오미미(고려대학교); Hwan Shin(Korea University); Tae Yong Park(Korea University); Sang Woo Kim(Korea University); Jong Jin Park(Korea University); Seung Min Jeong(Korea University)"
] | Purpose: This study was designed to evaluate the role of PDE5 inhibitors as combination therapy with conventional treatment of Peyronie’s disease (PD).
Materials and Methods: From July 2007 to October 2010, 35 Patients were divided into two groups. Group I (N=14) received PDE5 inhibitors in addition to conventional treatment with tamoxifen and acetyl L-carnitine, while group II (N=21) received only conventional treatment. The follow-up duration was at least 12 weeks after the active therapy of PD. Outcomes were assessed by pain relief, successful attempts for sexual intercourse, resolution of the plaque and any occurring complications.
Results: In the efficacy of overall treatment of 35 patients, 94.3% patients experienced successful sexual intercourse, while 5.7% experienced pain on erection, and 25.7% showed a decrease in plaque size. The analysis of parameters before treatment showed no significant difference between groups in terms of successful attempt at sexual intercourse (p=0.583) and pain on erection (p=0.445). Furthermore, there was no difference between groups after treatment in terms of successful attempts at sexual intercourse (p=0.766), pain on erection (p=0.766) and change in plaque size (p=0.445). However, successful intercourse and pain relief after treatment showed significant change irrespective of groups (p＜0.05). While the addition of a PDE5 inhibitor did not show any significant improvement in clinical outcome measures, the satisfaction of patient was higher in patients who received combination treatment (p=0.042).
Conclusions: Although the effect of PDE5 inhibitor for pain relief, successful intercourse and resolution of plaque size was not significant, patients who received PDE5 inhibitors had a more satisfaction of treatment of PD. Further prospective studies on the effect of PDE5 inhibitor in PD will be needed. | 비뇨기과학 | null | kci_detailed_000252.xml | |||
ART001581075 | oai_dc | Streptozotocin으로 유발된 당뇨병성 백서에서 복합생약제 (KBMSI-1)가 음경발기 및 음경해면체 조직에 미치는 영향 | The Effects of New Herbal Formula (KBMSI-1) on the Penile Erection and Corpus Cavernosum in Streptozotocin-induced Diabetic Rats | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"윤병일(가톨릭대학교); 김세웅(가톨릭대학교); 신태승(가톨릭대학교); 우장춘(가톨릭대학교); 김수진(가톨릭대학교); 김효신(가톨릭대학교); 하유신(가톨릭대학교); 김현정((주)한국전통의학연구소); 황성연((주)한국전통의학연구소)"
] | Purpose: The aim of this study was to investigate the effects of new herbal formula (KBMSI-1) on erectile dysfunction in streptozotocin-induced diabetic rat model.
Materials and Methods: We used male Sprague-Dawley rats aged 12 weeks and divided into three groups; control (n=8), diabetes (DM) (n=8), DM＋KBMSI-1 200 mg/kg treatment (n=8) groups. The DM groups received a single intraperitoneal injection of streptozotocin (STZ). Distilled water was administered in the control and DM group. To investigate the penile erection, intracavernosal pressure (ICP) and intracavernosal pressure/mean arterial pressure (ICP/MAP) were recorded in all groups. Serial sections of the penis were used to perform Masson’s trichrome stain. We analyzed the expression of nNOS and eNOS concentration in the isolated corpus cavernosum by western blotting.
Results: Peak ICP/MAP ratio was markedly increased in the treatment group with KBMSI-1 compared with DM group (p＜0.05). Masson’s trichrome staining of corpus cavernosum showed increase in smooth muscle volume and the regular arrangement of collagen fibers in KBMSI-1 treatment group compared with DM group. Western blot analysis revealed that the penile expressions of nNOS and eNOS protein were significantly higher in KBMSI-1-treated group than in DM group.
Conclusions: This study showed that herbal formulation of KBMSI-1 enhances the penile erection and the level of eNOS and nNOS expression of penile corpus cavernosum in streptozotocin-induced diabetic rat model. | 비뇨기과학 | null | kci_detailed_000252.xml | |||
ART001581096 | oai_dc | 전립선비대증 환자에서 경요도전립선절제술 후 급성요폐 발생에 영향을 미치는 인자 | Factors Causing Acute Urinary Retention after Transurethral Resection of the Prostate in Patients with Benign Prostate Hyperplasia | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"양소전(영남대학교); 문기학(영남대학교); 지윤섭(영남대학교); 송필현(영남대학교); 김현태(영남대학교)"
] | Purpose: Urologists occasionally experience some cases of voiding failure after transurethral resection of prostate (TURP). Preoperative and postoperative factors attributable to acute urine retention (AUR) after catheter removal in post-TURP patients were evaluated and analyzed to determine the causative factors for AUR.
Materials and Methods: From June 2004 to May 2008, a total of 172 patients who underwent TURP due to symptomatic benign prostatic hyperplasia (BPH) were divided into the AUR group (n=21) and the control group (n=151). The AUR group was defined as patients with voiding difficulty within 24 hours and whose residual urine volume was above 400 ml after catheter removal. The control group was defined as patients without AUR. Age, duration of symptoms, International prostate symptom score (IPSS), Quality of life score (QoL), uroflowmetry, post-void residual urine volume, preoperative serum prostate specific antigen (PSA) level, preoperative prostate volume, resected prostate volume, rate of prostate resection [resected prostate volume/preoperative prostate volume×100], operative time and duration of catheter were retrospectively analyzed to identify which of these were the factors related with AUR after catheter removal in post-TURP patients.
Results: Preoperative prostate volume was higher (90.7±50.4 vs 64.4±32.7, p=0.002) and rate of prostate resection was lower (38.8±8.1 vs 50.5±12.4, p＜0.001) in AUR group compared to control group. And age, duration of symptoms, IPSS, QoL, uroflowmetry, post-void residual urine volume, preoperative serum PSA level, resected prostate volume, operative time and duration of catheter were not statistically significant in both groups. The multivariate analysis subsequently showed that preoperative prostate volume (p=0.010, OR=1.040) and rate of prostate resection (p=0.001, OR=0.901) were independent factors related with AUR after catheter removal in post-TURP patients.
Conclusions: The incidence of AUR after catheter removal was higher in post-TURP patients with high preoperative prostate volume and low rate of prostate resection. Therefore the surgeon’s effort to increase the rate of prostate resection, especially in patients with large prostate volume, may lower the incidence of postoperative AUR. | 비뇨기과학 | null | kci_detailed_000252.xml | |||
ART001581106 | oai_dc | A Case of Xanthogranulomatous Prostatitis Concurrent with a Prostatic Abscess | A Case of Xanthogranulomatous Prostatitis Concurrent with a Prostatic Abscess | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"Kweon Sik Min(Inje University); Seung Yeob Oh(Inje University); 전지연(인제대학교); Jea Doo Um(Inje University); Sung Hyup Choi(Inje University); 정수진(인제대학교부속부산백병원)"
] | Xanthogranulomatous prostatitis is a rare inflammatory condition of the prostate. We report a case of xanthogranulomatous prostatitis. An 82-year-old man presented to our emergency department complaining of gross hematuria. A hard, enlarged, non-tender prostate was palpated on digital rectal examination. Urinalysis showed hematuria and pyuria, and the complete blood count (CBC) revealed leukocytosis. The prostate-specific antigen (PSA) level was elevated at 86.8 ng/ml. Computed tomography (CT) showed an enlarged prostate (volume 100 ml) that protruded into the bladder base. In the left lobe of the prostate, a 1.2×1.1-cm abscess was seen. Transurethral resection of the prostate was done. The pathological diagnosis was xanthogranulomatous prostatitis. The natural progression of the disease is unknown because of the paucity of cases and long-term follow-up reports. To evaluate the pathogenesis and long-term features of progression of this disease, more clinical cases should be collected. | 비뇨기과학 | null | kci_detailed_000252.xml | |||
ART001547387 | oai_dc | Penile Squamous Cell Carcinoma Diagnosed following Treatment of Urethrocutaneous Fistula after CO_2 Laser Therapy for Misdiagnosed Penile Lesion: Report of a Case | Penile Squamous Cell Carcinoma Diagnosed following Treatment of Urethrocutaneous Fistula after CO_2 Laser Therapy for Misdiagnosed Penile Lesion: Report of a Case | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"김영주(제주대학교); 허정식(제주대학교); 김성대(제주대학교); 김현주(제주대학교); 맹영희(제주대학교)"
] | The complications of the treatment of penile lesion are wide ranging, urethrocutaneous fistula being one of the less common. This complication affects the ventral aspect of the penis. We present a rare case of urethrocutaneous fistula after vaporization of penile lesion by CO_2 Laser. One fistula was at ventral aspect of the penis. A 43-year-old male presented with passage of urine from one opening. He had undergone a vaporization by CO_2 laser, 2 times. Urethrocutaneous fistula repairs was performed with biopsy of the edge of fistula site. Squamous cell carcinoma was confirmed. He subsequently underwent a partial penectomy. It is very important that biopsy was performed before vaporization of even small size skin lesion. This case is reported along with a brief review of the literature. | 비뇨기과학 | null | kci_detailed_000252.xml | |||
ART001547377 | oai_dc | Effects of Androgen on the CardiovascularSystem in the Aging Male | Effects of Androgen on the CardiovascularSystem in the Aging Male | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"김진욱(고려대학교); 문두건(고려대학교); 김제종(고려대학교)"
] | Testosterone decrease in men with age has become well established. As such, several modes of testosterone replacement therapy have become available, primarily for supplementation to alleviate the effects of age associated hypogonadism, as manifested by frailty, sarcopenia, poor muscle quality, decreased libido and erectile functions. Recent investigations have found significant association between hypogonadism and cardiovascular disease, type 2 diabetes, obesity and dyslipidemia. The association is more clearly presented in patients receiving androgen deprivation therapy for prostate cancer. Furthermore, testosterone supplementation restores arterial vasoreactivity, reduces proinflammatory cytokines, total cholesterol, and triglyceride levels, and improves endothelial function and insulin sensitivity. Future long term trials should be performed to identify persistent benefits and safety of this treatment. | 비뇨기과학 | null | kci_detailed_000252.xml | |||
ART001547386 | oai_dc | 성선 기능저하증을 보인 Prader-Willi Syndrome | Prader-Willi Syndrome with Hypogonadism | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"이길호(단국대학교)"
] | Prader-Willi syndrome (PWS) is a rare genetic disease caused by a deletion or disruption of genes in chromosome 15. Commonly associated characteristics of this disorder include obesity, mental retardation, short stature, and hypogonadotropic hypogonadism. A 3-year-old-boy who initially presented hypoplastic scotum, small penis and bilateral cryptorchism was confirmed the diagnosis of PWS using of with genetic tests. Finally, he was taken bilateral orchiopexy. | 비뇨기과학 | null | kci_detailed_000252.xml | |||
ART001547383 | oai_dc | 재생검을 통해 전립선암으로 진단받은 환자의 임상적 예측요인 | Clinical Predictive Factors in Patients with Prostate Cancer Diagnosed by Repeat Prostate Biopsy | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"주관중(성균관대학교); 권칠훈(성균관대학교)"
] | Purpose: We investigated the predictive factors in patient with prostate cancer diagnosed by repeat prostate biopsy, where initial prostate biopsy results were negative for malignancy.
Materials and Methods: Between March 2000 and June 2007, 1280 men with suspected prostatic cancer underwent transrectal ultrasound guided needle biopsy of the prostate, with 148 (11.6%) diagnosed as having prostate cancer. Of 1132 men whose biopsy results were negative for malignancy, 655 whose prostate specific antigen (PSA) was elevated persistently underwent second biopsy, and 462 underwent third biopsy as the same course. Twelve core biopsies were performed in the majority of patients. To determine predictive factors, we evaluated prostate volume, serum PSA, percent free PSA, PSA density (PSAD), transition zone PSAD, PSA velocity (PSAV) and pathological report of previous biopsy between the men with cancer detection and the men with negative biopsy in second and third biopsy.
Results: Overall cancer detection rate was 16.3% (208/1280). From the first, second and third biopsies, the cancer detection rate were 11.6, 5.5 and 5.2%, respectively. There were significant differences in percent free PSA, transition zone PSAD, PSAV between cancer and negative biopsy groups after serial repeat biopsies (p＜0.05). Multivariate logistic regression analysis revealed that the transition zone PSAD, PSAV, and presence of either atypical small acinar proliferation (ASAP) or high grade prostatic intraepithelial neoplasia (HGPIN) in initial biopsy specimen were significant predictors for prostate cancer diagnosed by repeat biopsy.
Conclusions: Of the men with negative results on the first biopsy, 60 (5.4%) were diagnosed prostate cancer after serial biopsies. The transition zone PSAD, PSAV, and presence of either ASAP or HGPIN in initial biopsy specimen are predictable factors for prostate cancer detection on repeat biopsy. | 비뇨기과학 | null | kci_detailed_000252.xml | |||
ART001547382 | oai_dc | Medical Profession's Awareness and Attitude Toward the Sexuality of Cancer Patients in South Korea | Medical Profession's Awareness and Attitude Toward the Sexuality of Cancer Patients in South Korea | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"Jun Ho Lee(Sungkyunkwan University); Sung Won Lee(Sungkyunkwan University); Deok Hyun Han(Sungkyunkwan University); Tai Young Ahn(University of Ulsan); Sung Ho Ju(Sungkyunkwan University); Byung Kuk So(Sungkyunkwan University)"
] | Purpose: To investigate the practice and attitude of healthcare professionals toward the sexuality of cancer patients.
Materials and Methods: The subjects were comprised of doctors and nurses who served at two medical centers. Questionnaires consisted of five domains and fourteen questions were disseminated via emails in March 2009. The first domain (3 questions) pertained the recognition of sexual dysfunction in cancer patients, the second (2 questions) pertained cancer patients’ experience of sexual dysfunction, the third (3 questions) pertained the attitude to cancer patients with sexual dysfunction, the fourth (3 questions) pertained capacity for sexual dysfunction treatment, and the fifth (3 questions) pertained problems or difficulties encountered when facing cancer patients’ sexual dysfunction.
Results: Three hundred and twenty-six men and women completed the questionnaires, giving a response rate of 85.4%. The mean age was 33.6 years. The proportion of doctors and nurses were respectively 48.2% and 51.8%. The proportion of males and females were 29.8%, and 70.2%, respectively. Ninety point five per cent (90.5%) of respondents answered that cancer patients’ sexual dysfunction is important to quality of life. However, fewer medical professionals (27.4%) give an affirmative answer that patients requested sexual dysfunction therapy. The occurred particularly less frequently in physicians (13.2%) than in surgeons (55.6%). Fifty-four point six (54.6%) percent of respondents said that they tried to resolve the problem when patients asking for treatment of sexual dysfunction. Only 38.3% of respondents experienced little or no difficulty in behaving naturally when counseling cancer patients about their sexual dysfunction. Female doctors and nurses more often experience embarrassment when addressing sexuality with patients. In addition, most respondents (84.0%) felt that theoretical knowledge on cancer patients’ problems is needed.
Conclusions: Most healthcare professionals agreed that sexual problems of cancer patients were important for quality of life. However, they frequently felt a lack of communicating skills and theoretical knowledge. Education programs on this issue and an appropriate contact system with specialists should be established. | 비뇨기과학 | null | kci_detailed_000252.xml | |||
ART001547380 | oai_dc | 정계정맥류 유발 백서에서 고환조직의 변화와 정자 형성에 대한 안토시아닌의 효과 | The Changes of Testis and the Effects of Anthocyanin on Spermatogenesis in Rat Induced Varicocele | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"장훈(가톨릭대학교); 김세웅(가톨릭대학교); 김수진(가톨릭대학교); 육승모(가톨릭대학교); 한동석(가톨릭대학교); 하유신(가톨릭대학교); 홍성후(가톨릭대학교); 이지열(가톨릭대학교); 황태곤(가톨릭대학교); 황성연(한국전통의학연구소)"
] | Purpose: Varicocele is known as a main cause of primary male infertility and it supposed to be associated with oxidative stress. Anthocyanin is known as a natural plant pigment and novel antioxidant. This study was designed to investigate the effects of anthocyanin on a rat model of varicocele.
Materials and Methods: Twenty four male rats, induced varicocele by partial obstruction of left renal vein, were divided into four experimental groups: the group induced varicocele for four weeks without anthocyanin, the group received anthocyanin (80 mg/kg) right after varicocele induction, group induced varicocele for eight weeks without anthocyanin, and the group received anthocyanin (80 mg/kg) after four weeks observation following varicocele induction. After anthocyanin treatment, testes from the rats in all groups were removed, weighed, and subjected to histological examination. Apoptosis in the testes was measured by the TUNEL assay. And the oxidative stress was evaluated by measurement of 8-hydroxy-2'-deoxyguanosine (8-OHdG).
Results: Induction of varicocele led to decreasing left testis weight, decreasing spermatogenic cell density significantly (p＜0.05). Also it led to increasing apoptotic body counts and increasing concentration of 8-OHdG significantly (p＜0.05). However administration of anthocyanin right after varicocele induction prevent this change meaningfully (p＜0.05). In group received anthocyanin after four weeks observation following varicocele induction, interestingly, there was no significant difference in testis weight, spermatogenic cell density, apoptotic body count and concentration of 8-OHdG compared to group induced varicocele for eight weeks without anthocyanin administration.
Conclusions: These results suggest that anthocyanin is effective in decreasing the oxidative stress of testis in rat induced varicocele and may be effective in making a healthy sperm in patient of varicocele in early stage. However in patient under way in advanced stage, it is supposed that the anthocyanin cannot help having a protective effect from oxidative stress narrowly unless the condition of oxidative stress by varicocele is corrected. Further studies are needed to better understand the mechanisms and actions of anthocyanin and varicocele, and these studies may lead to the clinical application of anthocyanin in preventing male infertility by varicocele. | 비뇨기과학 | null | kci_detailed_000252.xml | |||
ART001547381 | oai_dc | Role of Clusterin and Tumor Necrosis Factor Receptors on the Apoptosis of Prostate Cancer Cells | Role of Clusterin and Tumor Necrosis Factor Receptors on the Apoptosis of Prostate Cancer Cells | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"주관중(성균관대학교)"
] | Purpose: In prostate cancer, the anti-apoptotic mechanism of sulfated glycoprotein-2 (clusterin) against tumor necrosis factor-alpha (TNF-α) receptors and the action of type 2 TNF-α receptor (TNFR2) were investigated.
Materials and Methods: TNF-α, agonistic-TNF type 1 receptor (TNFR1) antibody, agonistic-TNF-R2 antibody and their combination were treated in PC3 cell line with or without anti-clusterin. Cytotoxicity was assessed by trypan blue dye exclusion assay. By using flowcytometric analysis, the exact amount of apoptosis and their changes were assessed.
Results: Apoptosis was significantly increased in both agonistic-TNFR1 antibody and TNF-α treated cases after blocking the activity of clusterin. The more the anti-clusterin antibody added, the more the apoptosis occurred. The increase of total apoptosis was greater in TNF-α treated cells than in agonistic-TNFR1 antibody treated ones. However, there was no increase of apoptosis in agonistic-TNFR2 antibody and TNF-α with agonistic-TNFR2 antibody treated cases, respectively.
Conclusions: Clusterin prevents TNF-α induced apoptosis by affecting TNFR1. The difference in degree of apoptosis between agonistic-TNFR1 antibody treated cells and TNF-α treated ones suggests the possibility of the action of TNFR2. It may be associated with affinity of TNF-α to the tumor cell surface. | 비뇨기과학 | null | kci_detailed_000252.xml | |||
ART001547384 | oai_dc | 120W 고출력 레이저 광선택적 전립선 기화술의 임상경과 | Clinical Outcomes Analysis with Efficacy and Safety of 120W High-Power System Laser Photoselective Vaporization of the Prostate | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"최용선(가톨릭대학교); 김세웅(가톨릭대학교); 김수진(가톨릭대학교); 배웅진(가톨릭대학교); 조혁진(가톨릭대학교); 홍성후(가톨릭대학교); 이지열(가톨릭대학교); 황태곤(가톨릭대학교)"
] | Purpose: Several studies and papers have reported good short-term results for using 120W HPS laser PVP. Here we report the short-term and long-term clinical outcomes analysis with efficacy and safety of 120W HPS laser PVP for the treatment of BPH.
Materials and Methods: We performed a retrospective clinical analysis of 357 patients, who underwent 120W HPS laser PVP for the treatment of BPH from April, 2009 to Feb. 2011. The IPSS, Qmax and PVR values were evaluated preoperatively and postoperatively.
Results: The mean age at the surgery; 70.35±8.28, mean prostate size; 46.56±21.11 ml, and mean PSA was 4.16±4.35 ng/ml. Mean operation time was 41.8±34.1 min, and mean lasing time was 19.8±11.3 min. Mean applied energy was 134,294.9±225,211.5 J. Thirty cases of co-operation were done. Mean catheter indwelling time was 0.84±0.36 day, and mean hospital stay was 1.1±0.2 day. The blood loss was minimal so transfusions were not needed. The baseline IPSS-sum; 19.61±9.13, QoL score; 4.28±1.02, Qmax; 7.94±5.51 ml/sec, PVR; 101.62±102.58 ml, At 1 month, IPSS-sum; 8.64±7.34, QoL score; 2.19±1.48, Qmax; 13.32±8.94 ml/sec, PVR; 32.54±46.07 ml was noted. At 12 months, IPSS-sum; 8.33±5.04, QoL score; 1.33±1.08, Qmax; 15.75±2.90 ml/sec, PVR; 21.56±31.28 ml was noted. Within 1 month of operation, 18 cases of dysuria and 27 cases of retention were reported but these were resolved with medication and observation. Compared with preoperative values, there were statistical improvements after the operation.
Conclusions: 120W HPS laser showed statistical improvements after 1 month operation and these results were sustained for 12 months. Although limitations, our long term experience suggest that significant improvements in symptomatic and urodynamic outcomes of 120W HPS laser PVP. | 비뇨기과학 | null | kci_detailed_000252.xml | |||
ART001547378 | oai_dc | 토끼에서 알파 환원효소억제제 (5-alpha Reductase Inhibitor)의 단기투여가 음경해면체 및 정낭조직의 수축이완과 정액성상에 미치는 영향: 예비연구 | The Effects of 5-alpha Reductase Inhibitor on Contraction of Erectile Tissue and Secretion of Seminal Fluid in Male Rabbits: Preliminary Study | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"이신영(서울의료원 비뇨기과); 김세철(중앙대학교); 하문수(중앙대학교); 응웬 하이박(중앙대학교); 이주형((주)바이오컬쳐); 이장희(바이오컬쳐 (주)); 명순철(중앙대학교)"
] | Purpose: Adverse sexual experiences such as erectile dysfunction (ED), loss of libido, and ejaculation disorders have been consistent side effects of 5-alpha reductase inhibitors (5ARI). The aim of this study was to evaluate the effects of 5ARI (finasteride) treatment on semen parameters and contraction of the corpus cavernosum and seminal vesicles in male rabbits.
Materials and Methods: Adult male New Zealand White rabbits (n=10) were randomized into 2 groups: finasteride-treatment (5ARI) group and vehicle-treatment (control) group. The 5ARI group received daily oral finasteride (10 mg/day) by gavage for 4∼6 weeks, and the control group received the same concentration of the vehicle. The semen volume and semen parameters between the 2 groups were compared; thereafter, contraction or relaxation responses of smooth muscle strips of the corpus cavernosum and seminal vesicles were observed in an organ bath.
Results: Semen magnesium (14.2 vs 5.1 mg/dl) and protein (2.2 vs 1.6 g/dl) concentrations were significantly lower in the 5ARI group than in the control group. The concentrations of other parameters such as electrolytes (Na/K/Cl), fructose, and citrate did not differ between the 2 groups. The contractile responses to norepinephrine (NE) significantly increased in the 5ARI group compared to the control group and the relaxation responses to acetylcholine (ACh) or sodium nitroprusside (SNP) also increased in the 5ARI group. The contractile responses of the seminal vesicular strips to NE significantly decreased in the 5ARI group compared with the control group.
Conclusions: The results suggest that finasteride may decrease contraction of seminal vesicle tissue and alter semen parameters. The effect of finasteride on erectile tissue was double-faced; enhancing both contraction and relaxation. Further study is needed in this respect. | 비뇨기과학 | null | kci_detailed_000252.xml | |||
ART001547379 | oai_dc | 흰쥐의 방광출구 부분폐색에 의한 음경해면체의평활근에서의 Endothelin-1의 변화 | Changes of Endothelin-1 in Rats Corpus Cavernosum SmoothMuscle of Partial Bladder Outlet Obstruction | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"김기호(동국대학교); 이경섭(동국대학교); 서영진(동국대학교)"
] | Purpose: Lower urinary tract symptoms and erectile dysfunction (ED) are common disorders in men and increase with age. Recently, there has been evidence to suggest that patients with high benign prostatic hyperplasia symptom scores have an increased frequency of ED. This study was performed to evaluate the change of the expression of endothelin-1 (ET-1) in the corpus cavernosum by inducing partial bladder outlet obstruction (PBOO) in a rat model.
Materials and Methods: Eight Sprague-Dawley male rats were used for induction of PBOO by placing a 25 gauge angioneedle sheath around the urethra, then ligating the bladder neck with 3-0 vicryl suture and six sham-operated rats were ligated very loosely without causing obstruction. At three and five weeks after PBOO, the distal portion of the ligated penile tissues was dissected for immunohistochemical staining of ET-1 in the vascular endothelial cell.
Results: ET-1 was weakly expressed (+) in the smooth muscle layers of the control group and a very strong expressed (++++) in the experimental group on 3 weeks after PBOO. However, there was no expression in the experimental group on 5 weeks after PBOO. There was no expression (−) in the vascular endothelial cells of the control group and very strong expression (++++) in the experimental group on 3 weeks after PBOO. Howerver, there was no expression in the experimental group on 5 weeks after PBOO.
Conclusions: The changes of penis by inducing partial bladder outlet obstruction in the rats were associated with increased ET-1 in the vascular and peri-vascular smooth muscle cells of the corpus cavernosum. | 비뇨기과학 | null | kci_detailed_000252.xml | |||
ART001547385 | oai_dc | 전립선비대증으로 인한 하부요로증상 환자의생약제제 이용현황: 단일기관연구 | The Use of Phytotherapy in Male Patients with a Lower Urinary Tract Symptoms Due to Benign Prostatic Hyperplasia: Single Center Study | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"박현준(부산대학교); 박남철(부산대학교); 김현우(부산대학교); 최상민(부산대학교); 김창훈(부산대학교)"
] | Purpose: Recently, the use of complementary and alternative medicine (CAM) is increasing among patients with low urinary tract symtoms (LUTS) caused by benign prostate hyperplasia (BPH). We assessed current usage and awareness of phytotherapy, the most ubiquitous CAM, in BPH/LUTS patients.
Materials and Methods: A total of 204 patients with BPH who completed a questionnaire between January 2009 and December 2010 were enrolled. The questionnaire was composed of questions about age, education level, accompanying disease, type of phytotherapy, route of purchase, reason of taking medicine and whether the patient is using phytotherapy in combination with conventional medicine.
Results: The mean age was 55.5±8.7 years. 56 of the total patients (27.5%) were using phytotherapy. The patients who were accompanied with erectile dysfunction used phytotherapy the most. The most commonly used phytotherapy for prescription and health functional food was Saw palmetto. The most common route of purchase was by clinician's prescription (46.4%). Most patients answered the dissatisfaction of present treatment's effect as the main reason for using phytotherapy. The number of patients who were taking combination therapy of BPH medication and phytotherapy was much more than using phytotherapy alone.
Conclusions: 27.5% of patients who had BPH/LUTS were using phytotherapy. This is the point of time for many urologists to acquire the knowledge of studies and latest research of phytotherapy and use it in treating patients with BPH/LUTS. | 비뇨기과학 | null | kci_detailed_000252.xml | |||
ART001547376 | oai_dc | Late Onset Hypogonadism and Lower Urinary Tract Symptoms: New Insights | Late Onset Hypogonadism and Lower Urinary Tract Symptoms: New Insights | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"Farid Saad(Bayer Schering Pharma); Louis J Gooren(Gulf Medical University School of Medicine)"
] | Late onset hypogonadism was originally perceived as an academic topic. In the course of two decades it has become an issue impacting on everyday urology. For long time clinical conditions, such as cardiovascular disease, diabetes mellitus type 2, sexual dysfunction and urological complaints affecting the aging male, were regarded as independent clinical entities, treated by a number of medical specialists. Over the last decade their close interrelationship could be convincingly demonstrated. Declining testosterone levels in elderly appear to be central to the above pathologies. Epidemiological studies show that prostate disease occurs at an age when serum testosterone levels decline. It is now clear that erectile dysfunction is a local expression of endothelial dysfunction of the cardiovascular system. Testosterone deficiency is associated with an increased incidence of cardiovascular disease and diabetes mellitus, sequels of the metabolic syndrome. There is a relationship between the metabolic syndrome and lower urinary tract symptoms (LUTS). The pathophysiology of LUTS has much in common with the pathological substrate of erectile dysfunction with regard to vascular factors and the role of nitric oxide, explaining why phosphodiesterase type 5 inhibitors have often a beneficial effect on LUTS. It must be regarded an omission not to include testosterone measurements in the work-up of the LUTS, erectile dysfunction, cardiovascular disease and diabetes mellitus type 2. These conditions hinge on testosterone deficiency, and if testosterone deficiency can be proven, testosterone treatment can improve these conditions. There are many sites in the lower urinary tract where testosterone exerts effects. | 비뇨기과학 | null | kci_detailed_000252.xml | |||
ART001473134 | oai_dc | 남성 성기능장애의 평가를 위한 설문검사 | Male Sexual Dysfunction Questionnaires | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"박현준(부산대학교); 박남철(부산대학교)"
] | The symptoms of male sexual dysfunction are somewhat subjective. Although vascular and neurological examinations are used to evaluate sexual function, the results of these examinations are often not consistent with the severity of the symptoms. Consequently, many psychometrically validated assessment tools have been designed solely and specifically to evaluate male sexual dysfunction. They can quantify the subjective symptoms of patients using scoring systems. These recently developed questionnaires assess not only sexual function but also the partner relationship and quality of life. They are also useful for assessing the treatment response. Of the various questionnaires, the International Index of Erectile Function (IIEF), International Index of Erectile Function-5 (IIEF-5), Male Sexual Health Questionnaire (MSHQ), Androgen Deficiency in Aging Males (ADAM), Aging Males' Symptoms (AMS) rating scale, and Premature Ejaculation Diagnostic Tool (PEDT) have been translated into Korean and validated. This study reviews the various questionnaires on male sexual dysfunction and assesses which ones are appropriate for aspects of male sexual dysfunction, such as erectile dysfunction, late-onset hypogonadism, and premature ejaculation. | 비뇨기과학 | null | kci_detailed_000252.xml | |||
ART001473309 | oai_dc | 미세 절제된 생쥐 전립선의 Uroplakin mRNA 발현 | Uroplakin mRNA Expression in the Micro-dissected Mouse Prostate | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"이동현(이화여자대학교); 이길호(단국대학교)"
] | Purpose: Prostatitis is a common condition with a significant effect on quality of life. Even though the etiology of chronic prostatitis remains unclear, certain bacterial infections may play a major role. In recent studies, E. coli, one important etiology of urinary tract infection, was found to mediate invasion into the bladder epithelium after binding uroplakin Ia in the apical membrane of the urinary bladder. Because E. coli is also an important pathogen for bacterial prostatitis, we investigated the uroplakin mRNA expression in micro-dissected mouse prostates.
Materials and Methods: We harvested the urinary bladder, ventral prostate, dorso-lateral prostate, and coagulating gland from 3 male imprinting control region (ICR) mice. The total RNA was extracted, cDNA was prepared, and finally the five target genes--uroplakin Ia, Ib, II, III, and β-actin were amplified. We also examined the expressed sequence tags (EST) about above four uroplakin genes from mouse EST data.
Results: Uroplakin Ia, Ib, II, and III were expressed in the urinary bladder. However, only uroplakin Ia was definitively expressed in the ventral prostate. Uroplakin Ib and II were weakly expressed in the ventral, dorso-lateral, and coagulating prostate. Uroplakin III was not expressed in the prostate tissue. The mouse RNA transcripts in the EST data also showed similar results to uroplakin expression in the prostate.
Conclusions: These results suggest that the mouse ventral prostate may be an adequate locus for acute or chronic bacterial prostatitis study. Further in-vitro bacteriologic studies of the ventral prostate will help reveal the mechanisms of chronic bacterial prostatitis. | 비뇨기과학 | null | kci_detailed_000252.xml | |||
ART001473315 | oai_dc | Polychlorinated Biphenyls (PCBs, Aroclor 1254)의 백서 정자 독성에 대한 팔미원의 효과 | Ameliorative Effect of Palmiwon on Polychlorinated Biphenyl (PCB, Aroclor 1254)-Induced Spermiotoxicity in the Rat | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"김상득(전북대학교); Zhen Zhao(전북대학교 의과대학 비뇨기과학교실); 김재현(동신대학교 한의과대학); 정종길(동신대학교); 최보람(전북대학교 의과대학 비뇨기과학교실); 정수영(전남한방산업진흥원); 조정희(전남한방산업진흥원); 박종관(전북대학교)"
] | Purpose: Polychlorinated biphenyls (PCBs, Aroclor 1254), synthetic chlorinated organic compounds, are known to decrease thyroid function, sperm count, and fertility, and increase the risk of testicular cancer; they may have serious effects on male reproduction. The aim of this study was to investigate the possible protective role of palmiwon on PCB-induced spermiotoxicity in rats.
Materials and Methods: 90-day-old male Sprague Dawley rats were randomly divided into three groups, each consisting of ten animals. The control group (Group I) received corn oil, the second group of rats (Group II) was administered 2 mg/kg body weight/day of Aroclor 1254＋corn oil intraperitoneally for 30 days. The third group of rats (Group III) was treated with 2 mg/kg body weight/day of Aroclor 1254＋corn oil intraperitoneally plus palmiwon (300 mg/day) orally for 30 days. Twenty-four hours after the last treatment, the animals were killed by decapitation. Their serum testosterone levels was measured before and after the experimental medication was taken, and the number and motility of sperm, which had been collected from the cauda epididymal region, were evaluated.
Results: The results of this experiment show that treatment with palmiwon significantly improved sperm motility and number in rats that had been exposed to PCBs. There was no marked difference in body weight, testis weight, or epididymis weight among the groups. Nor were there any significant pathological differences in the testes among the groups. Conclusions: Palmiwon has the potential for treating PCB-induced spermiotoxicity. More experiments with larger samples and a longer period of treatment are needed. | 비뇨기과학 | null | kci_detailed_000252.xml | |||
ART001473127 | oai_dc | 혈정액증 | Hematospermia | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"정우식(이화여자대학교 의학전문대학원 비뇨기과)"
] | Hematospermia, the presence of blood in the semen is a distressing symptom in sexually active men. However, it is usually a self-limiting condition. Although its exact incidence remains unclear, physicians should evaluate such patients closely and thoroughly because of the possibility of underlying malignancy, particularly prostate cancer. Still, confusion remains about how best to evaluate and treat men with hematospermia. The following paper reviews the literature to explain the cause, diagnostic work-up, and management strategies in patients with hematospermia. | 비뇨기과학 | null | kci_detailed_000252.xml | |||
ART001473137 | oai_dc | Streptozotocin으로 유발된 당뇨병 백서에서 시기별 발기력과 Phosphodiesterase Type 5 억제제에 대한 반응의 변화 | Time-dependent Changes in Erectile Function and Responsiveness to Phosphodiesterase Type 5 Inhibitor in Streptozotocin-induced Diabetic Rats | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"조성용(서울대학교); 김수웅(서울대학교)"
] | Purpose: The aim of this study was to investigate time-dependent changes in erectile function and responsiveness to type 5 phosphodiesterase (PDE5) inhibitor in streptozotocin-induced diabetic rats.
Materials and Methods: Seventy-five 8-week-old male Sprague-Dawley rats were randomly divided into two groups: diabetic (n=50) and control (n=25). The diabetic group received a single intraperitoneal injection of streptozotocin. The diabetic rats and age-matched control rats underwent cavernosometry before and after administration of DA-8159 (a novel PDE5 inhibitor) at 6, 8, 10, 12, and 14 weeks after induction of diabetes. The erectile response elicited by electrical stimulation of the cavernous nerve (3 V, width 0.2 msec, duration 30 seconds) was measured at several frequencies (2.5, 5, 10, and 20 Hz). Intracavernous pressure (ICP) and mean arterial pressure (MAP) were continuously monitored. Comparisons were made for ICP/MAP and areas under the curve (AUC) corresponding to the duration of electrical stimulation. The AUC was also corrected by the MAP.
Results: Diabetic rats maintained normal erectile responses until 6 weeks after diabetic induction. Following 8 weeks of diabetes, the rats showed significantly lower ICP/MAP and AUC/MAP at higher frequencies of nerve stimulation, which were normalized to controls by administration of DA-8159. In contrast, both physiologic parameters were significantly decreased in the 10-week diabetic rats and ICP/MAP at 20 Hz stimulation frequency recovered only by injection of DA-8159. At more than 12 weeks of diabetes, the rats demonstrated severe deterioration of erectile function, which did not fully respond to PDE5 inhibitor.
Conclusions: Findings from this study indicate that impairment of erectile function is followed by decreased responsiveness to PDE5 inhibitor during the course of diabetes. | 비뇨기과학 | null | kci_detailed_000252.xml | |||
ART001473302 | oai_dc | Transforming Growth Factor-β1을 발현하는 아데노바이러스를 이용한 음경해면체섬유화 동물모델의 확립 | Establishment of a Cavernous Fibrosis Model in a Rat Using Adenovirus Expressing Transforming Growth Factor-β1 | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"류지간(인하대학교); 오승민(연세대학교 의과대학); Hai Rong Jin(인하대학교 의과대학 비뇨기과학교실, 음경 혈관-신경 재생 연구실); 김도경(인하대학교 의과대학 비뇨기과학교실, 음경 혈관-신경 재생 연구실); 강용진(인하대학교 의과대학 비뇨기과학교실); 장진혁(인하대학교 의과대학 비뇨기과학교실); 서준규(인하대학교)"
] | Purpose: Transforming growth factor-β1 (TGF-β1) has been implicated in cavernous fibrosis due to a variety of causes of erectile dysfunction (ED), such as diabetes mellitus and post-radical prostatectomy. To examine the role of the TGF-β signaling pathway in cavernous fibrosis, we established a rat model of cavernous fibrosis by using adenovirus expressing TGF-β1 (ad-TGF-β1).
Materials and Methods: Four-month-old male Sprague-Dawley rats received intracavernous injection of ad-TGF-β1 (1×108, 1×109, or 1×1010 virus particles [vp] in 100 μl of PBS) and the penis was harvested for histologic examination at 10, 20, or 30 days after injection (n=4 per group and per time point). Based on the initial findings, the animals were divided into three groups (n=6 per group): Group 1, age-matched control; Group 2, intracavernous injection of ad-LacZ (1×1010 vp/100 μl); and Group 3, intracavernous injection of ad-TGF-β1 (1×1010 vp/100 μl). At 30 days after injection, erectile function was evaluated during electrical stimulation of the cavernous nerve. The penis was then harvested and stained with Masson’s trichrome and antibody to smooth muscle α-actin.
Results: Masson’s trichrome staining revealed that intracavernous delivery of ad-TGF-β1 sufficiently induced cavernous fibrosis in a dose-dependent manner. The fibrotic scars persisted up to 30 days after injection at the highest dosage (1×1010 vp/100 μl), whereas no histologic evidence of cavernous fibrosis was found in the control rats or the ad-LacZ-injected rats. The rats receiving ad-TGF-β1 showed a higher cavernous collagen content and less smooth muscle content than the control rats or ad-LacZ-injected rats. Erectile function was significantly decreased in rats receiving ad-TGF-β1 compared with that in controls or rats receiving ad-LacZ.
Conclusions: This model induced by ad-TGF-β1 may play an important role in understanding the pathophysiologic mechanisms of cavernous fibrosis-associated TGF-β signaling and the development of new therapeutics targeting this pathway. | 비뇨기과학 | null | kci_detailed_000252.xml | |||
ART001473154 | oai_dc | Benfotiamine이 제2형 당뇨 쥐 신장에서 Phosphodiesterase Type 5 및 아형 발현에 미치는 영향 | Effect of Benfotiamine on the Expression of Phosphodiesterase Type 5 and Its Isoforms in Type 2 Diabetic Rat Kidneys | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"심종백(강동성심병원 비뇨기과); 양대열(강동성심병원 비뇨기과); 한영국(강동성심병원 비뇨기과); 이선주(강동성심병원 비뇨기과); 김효종(강동성심병원 비뇨기과); 정현철(강동성심병원 비뇨기과); 김성용(강동성심병원 비뇨기과); 김하영(강동성심병원 비뇨기과); 이영재(제주대학교)"
] | Purpose: The phosphodiesterases (PDEs) are critical components in the cyclic AMP/protein kinase A and the cyclic GMP/phosphokinase G signaling pathways. The cAMP and cGMP pathways are regulated by activation and dissolution of PDEs. Benfotiamine, a lipophilic derivation of thiamine is known an activator of transketolase, is reported to prevent diabetic nephropathy by decreasing proteinuria and reducing oxidative stress. We did this study to investigate the effect of benfotiamine in type 2 diabetic rat kidneys.
Materials and Methods: We prepared 10 male Long-Evans Tokushima Fatty (LETO: control) and 20 male Otsuka Long-Evans Tokushima Fatty (OLETF) rats, which developed non-insulin-dependent diabetes mellitus (NIDDM) naturally. An oral glucose tolerance test confirmed diabetic development in the OLETF rats at 26 weeks. We classified 10 of the OLETF rats into Group I, the no treatment group and the other 10 into Group II, the treatment group. Group II received 100 mg/kg benfotiamine after developing DM. At 44 weeks, we checked kidney weight, serum glucose, free testosterone, insulin, total cholesterol, and triglyceride before sacrifice. We designed the primers for rat PDE5, PDE5A1, and PDE5A2 genes were carried out semiquantitive multiplex RT-PCR. Immunohistochemical staining was performed for monoclonal mouse anti-cGB-PDE5 and mouse monoclonal anti-smooth muscle α-actin.
Results: For the Control Group, Group I, and Group II, kidney weight was 2.13±0.23, 2.08±0.22, and 1.94±0.44 g; serum glucose was 279.50±56.79, 338.00±55.00, and 314.71±139.1 mg/dl; free testosterone was 1.46±1.08, 1.05± 0.42, and 0.72±0.56 pg/dl; insulin was 1.03±0.43, 1.09±0.83, and 1.15±1.08 ng/ml; total cholesterol was 86.83±4.79, 132.00±7.69, and 118.14±30.93 mg/dl; and triglyceride was 78.83±16.47, 177.83±75.62, and 194.57±92.57 mg/dl, respectively. All three groups expressed PDE5, PDE5A1, PDE5A2 mRNA, but Group I PDE5 mRNA expression was lower than that of Group C, II. However, the expression of PDE5A1 and PDE5A2 mRNA was not significantly different among the three groups.
Conclusions: Serum cholesterol, triglyceride, and glucose were significantly higher in OLETF than in LETO rats. The PDEs were lower in diabetic rat (OLETF) kidneys and PDEs may play a significant role in the development of diabetic renal complications. Benfotiamine is suggested to increase expression of PDE5 mRNA in the type 2 diabetes rat kidney, but the difference in expression levels between PDE5A1 and PDE5A2 was not significant. These findings suggest that benfotiamine may play a specific role in diabetic changes of the rat kidney via a PDE5-related pathway, but it is not clear whether subtype PDE5A1 and PDE5A2 genes play a specific role | 비뇨기과학 | null | kci_detailed_000252.xml | |||
ART001473333 | oai_dc | 와파린 복용 중단과 연관된 음경지속발기증 | Priapism Associated with the Discontinuation of Oral Wafarin | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"송미호(순천향대학교); 두승환(순천향대학교); 양원재(순천향대학교); 송윤섭(순천향대학교)"
] | Priapism attributable to an anticoagulant drug has rarely been reported. Although the pathophysiology of this type of priapism is not well understood, most investigators contend that thromboembolic phenomena play either a causative or supportive role. We describe a case of priapism associated with the discontinuation of oral warfarin. | 비뇨기과학 | null | kci_detailed_000252.xml | |||
ART001473306 | oai_dc | 무정자증 환자의 고환 정자내 Chromatin Condensation 검사를 위한 Aniline Blue-eosin 염색법의 유용성 | Efficacy of the Aniline Blue-eosin Staining Method for Testicular Sperm Chromatin Condensation Assay in Azoospermia | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"박용석(관동대학교); 손지흔(관동대학교 의과대학 제일병원 생식생물학 및 불임연구실); 이중식(관동대학교 의과대학 제일병원 비뇨기과학교실); 서주태(관동대학교)"
] | Purpose: This study was performed to evaluate chromatin condensation of morphologically mature sperm using a modified aniline blue-eosin (AB-E) staining method in azoospermia.
Materials and Methods: Chromatin condensation was analyzed using an AB-E staining method in 61 cases (50 patients) of TESE or testicular biopsy with the patient’s own sperm. Obstructive azoospermia (OA) was present in 48 cases in 39 patients and non-obstructive azoospermia (NOA) was present in 13 cases in 11 patients, respectively. Immature sperm heads were stained dark blue, whereas mature sperm were stained red-pink by the eosin. The percentage of sperm chromatin condensation was calculated from the ratio of the number of red-pink sperm to the total number of sperm analyzed.
Results: The percentage of chromatin maturity was 37.7% vs. 30.3% in OA and NOA, respectively, of the total sperm cell count. The maturity of fresh testicular sperm was 38.3% and 36.3% in OA and NOA, respectively. Also, the maturity of thawed testicular sperm was 34.5% and 10.3% (p＜0.05) in OA and NOA, respectively. The maturity of fresh and thawed testicular sperm was 36.3% and 10.3% (p＜0.05), respectively, in NOA. These results suggest that chromatin condensation is less stable in sperm of NOA and freezing and thawing procedures may impair sperm chromatin condensation.
Conclusions: In our results, the aniline blue-eosin staining method improved the visualization of excessive histones in sperm and the diagnosis of sperm immaturity in morphologically normal testicular sperm. We found that AB-E staining method can be an effective method for analyzing testicular sperm chromatin condensation in azoospermia. | 비뇨기과학 | null | kci_detailed_000252.xml | |||
ART001473330 | oai_dc | Postcircumcision Color Change of the Glans Penis Associated with a 0.2% Lidocaine Dorsal Nerve Block | Postcircumcision Color Change of the Glans Penis Associated with a 0.2% Lidocaine Dorsal Nerve Block | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"김선옥(전남대학교); Jeong Seon Lee(Department of Urology, Chonnam National University Medical School, Gwangju, Korea); 박광성(전남대학교)"
] | We describe a case of temporary ischemic change of the glans penis after circumcision. A 36-year-old male exhibited an ischemic change in the color of the glans penis the day after receiving a dorsal penile nerve block for circumcision. After the third day, the color of the glans changed from black to dark brown. After 7 days, the glans returned to near normal skin color without other sequelae. | 비뇨기과학 | null | kci_detailed_000252.xml | |||
ART001473321 | oai_dc | 전립선비대증 유발 백서에서 검은 콩에서 추출한 안토시아닌이 미치는 영향 | The Effects of Anthocyanin Extracted from Black Soybean on a Benign Prostatic Hyperplasia-induced Rat Model | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"장훈(가톨릭대학교); 하유신(가톨릭대학교); 김수진(가톨릭대학교 의과대학 비뇨기과학교실); 윤병일(가톨릭대학교 의과대학 비뇨기과학교실); 한동석(가톨릭대학교); 육승모(가톨릭대학교 의과대학 비뇨기과학교실); 황태곤(가톨릭대학교); 김세웅(가톨릭대학교)"
] | Purpose: Anthocyanin is known as a water soluble natural pigment and potent antioxidant. We extracted anthocyanin mediating antioxidant reaction from black soybeans, administered the extract to rats induced prostatic hyperplasia, and evaluate the effect of anthocyanin.
Materials and Methods: Twenty four male rats were divided into 4 experimental groups: the control, BPH-induced, BPHinduced, and oral anthocyanin (40 mg/kg, 80 mg/kg)-administered groups. For exclusion of intrinsic testosterone influence, a bilateral orchiectomy was done on all except the control group. An experimental prostate hyperplasia was induced by the subcutaneous administration of 3 mg/kg testosterone propionate for 4 weeks to all except the control group. Anthocyanin administration was done in the last 4 weeks in the anthocyanin-administered groups. After 8 weeks, the prostates were removed and analyzed for their prostatic weight and histological examination. Then TUNEL staining was done on each group’s specimens, and they were analyzed for their apoptotic body counts.
Results: The mean prostate weight was found to be 674.17±28.24 mg, 1,098.33±131.31 mg, 323.00±22.41 mg, and 324.00±26.80 mg in the control, BPH-induced, and oral anthocyanin-administered (40 mg/kg, 80 mg/kg) groups, respectively. The BPH-induced group showed statistically significant increases in their prostate weights compared with the control group (p＜0.05) and the anthocyanin administered groups showed statistically significant decreases compared to the control and BPH-induced groups (p＜0.05). Histologically injected testosterone led to prostatic hyperplasia, but anthocyanin-administered groups experienced this change to a lesser extent. Apoptotic body counts in 5×400/HPF were found to be 3.67±0.86, 1±0.94, 15.67±2.36, and 28.33±1.71 in each group. The anthocyanin-administered groups showed statistically significant increases in apoptotic body counts compared with the control and BPH induced groups (p＜0.05).
Conclusions: In a prostatic hyperplasia-induced rat model, administration of anthocyanin showed the reduction of prostate weight and the increase of apoptosis. We thought that such results were caused by antioxidant reactions of anthocyanin, and administration of the anthocyanin may be effective in benign prostatic hyperplasia, which is the representative geriatric disease of the urological system. | 비뇨기과학 | null | kci_detailed_000252.xml | |||
ART001473324 | oai_dc | 백서에서 셀레늄 함유 온천수 음용이 혈중 Leptin과 IGF-1에 미치는 영향 | The Effect of Selenium-rich Hot Spring Water on Serum Leptin and IGF-1 in a Rat Model | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"윤병일(가톨릭대학교 의과대학 비뇨기과학교실); 김수진(가톨릭대학교 의과대학 비뇨기과학교실); 조혁진(가톨릭대학교); 하유신(가톨릭대학교); 홍성후(가톨릭대학교); 이지열(가톨릭대학교); 황태곤(가톨릭대학교); 김세웅(가톨릭대학교)"
] | Purpose: There have been reports that a higher serum level of selenium is related to a lower incidence of prostate cancer. Serum leptin and IGF-1 are factors related to metabolic syndromes which are also known to be related to prostate cancer, and the higher their levels, the higher the possibility of prostate carcinogenesis. Thus, we measured the serum levels of leptin and IGF-1 in rats that were given selenium-rich hot spring water to drink in an attempt to elucidate the role of selenium on prostate cancer prevention.
Materials and Methods: A total of twelve white SD rats was included in the study, and they were further divided into a control group (Group 1, n=6) induced to drink normal saline, and those rats that drank selenium-rich hot spring water for 4 weeks (Group 2, n=6). The hot spring water that we used was from the Kum-jin region of Korea, which contains a rich supply of the minerals selenium, vanadium, calcium and magnesium. The concentration of selenium in the hot spring water was 480 μg/l. The two groups were each given 50 ml/day of normal saline or selenium-rich hot spring water. After the period of the experiment, we drew blood samples from both groups and measured their serum leptin and IGF-1 levels using ELISA.
Results: The serum leptin level (pg/ml) was 964.04±127.77 in Group 1, and 531.92±151.04 in Group 2, allowing us to confirm that it was significantly less in those that drank the selenium-rich hot spring water (p＜0.05). Also, the serum IGF-1 levels (pg/ml) were 1,247.72±53.85 and 933.03±113.69 in Groups 1 and 2, respectively, which again, illustrated the significantly lower level in those rats that were given selenium-rich hot spring water (p＜0.05).
Conclusions: Significantly decreased serum levels of leptin and IGF-1 were observed in rats that drank selenium-rich hot spring water. A study of the long-term effect of selenium-rich hot spring water on prostate cancer is necessary; if it is indeed proven to have long-term effects, we believe it will become valuable in clinical practice. | 비뇨기과학 | null | kci_detailed_000252.xml | |||
ART001441653 | oai_dc | Association of Prostate Specific Antigen (PSA) Velocity with Age and Initial PSA in Healthy Korean Men | Association of Prostate Specific Antigen (PSA) Velocity with Age and Initial PSA in Healthy Korean Men | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"조영삼(성균관대학교); 주관중(성균관대학교)"
] | Purpose: Prostate specific antigen (PSA) is a test with relatively low specificity used for determination of risk for prostate cancer. PSA velocity (PSAV) has been used as a complimentary test. We investigated the association of PSAV with age and an initial PSA.
Materials and Methods: We enrolled 989 healthy men with initial PSA of 4.0ng/ml or lower. The PSA levels were measured at intervals of at least 12 months. We analyzed the influence of age and initial PSA on the PSAV.
Results: PSAV was directly correlated with age and the initial PSA. The initial PSA was not correlated with the PSAV when adjusted by age (r=0.009, p=0.773); age was correlated with PSAV when adjusted by initial PSA level (r=0.276, p<0.001). The mean PSAV in cases with initial PSA of 2.1-4.0 ng/ml was significantly greater compared to the cases with an initial PSA of 0-2.0 ng/ml (p<0.01). The ratio of the men with a PSAV greater than 0.75 ng/ml/year was significantly higher in cases with an initial PSA of 2.1-4.0 ng/ml (p<0.05).
Conclusions: PSAV is associated with age and an initial PSA level in healthy Korean men. Men with initial PSA of 2.1-4.0 ng/ml had an abnormal PSAV in high proportion, and therefore annual follow up PSA would be useful for the early detection of prostate cancer in these cases. | 비뇨기과학 | null | kci_detailed_000252.xml | |||
ART001441672 | oai_dc | 고환보형물 삽입술 후 환자의 만족도 | Patient Satisfaction after Testicular Prosthesis Implantation | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"송필현(영남대학교 의과대학 비뇨기과학교실); 배장호(영남대학교); 김종민(영남대학교); 김현태(영남대학교); 문기학(영남대학교)"
] | Purpose: We investigated the follow-up result and patient satisfaction after testicular prosthesis implantation by the 11-item questionnaire.
Materials & Methods: Among 29 patients who underwent testicular prosthesis implantation between January 2000 and April 2009, 24 patients who spent over 6 months after surgery and agreed to this investigation were enrolled in this study. All the patients were evaluated specially designed questionnaires retrospectively.
Results: The mean age of subjects was 23.2±7.1 years and mean follow-up duration was 48.9±24.5 months. The domains about size, position, shape, weight and comfort of prostheses showed positive responses with 70.8%, 66.7%, 58.3%, 66.7% and 70.8%, respectively. And 87.5% of the patients replied that they got increased selfconfidence postoperatively. In accordance with this study, all of them would recommend the operation to other patients who suffering from loss of testis.
Conclusions: Testicular prosthesis implantation showed simple surgical procedure with low complication rate. It seemed to recover patients’psychiatric trauma and also encourage self-confidence in social life. | 비뇨기과학 | null | kci_detailed_000252.xml | |||
ART001441931 | oai_dc | 음경배부신경절제술의 합병증으로 발생한 음경해면체류 | Aneurysmal Dilatation of Corpus Cavernosum as an Unusual Complication of Dorsal Penile Neurectomy | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"윤현석(이화여자대학교 의학전문대학원); 유재영(이화여자대학교 의학전문대학원); 전계민(이화여자대학교); 구진모(이화여자대학교 의학전문대학원 비뇨기과학교실); 유석선(이화여자대학교 의학전문대학원 비뇨기과학교실); 정우식(이화여자대학교)"
] | A 43-year-old man presented painless protruding mass on left side of penile shaft only during erection. 1 year ago he had a dorsal penile neurectomy for the treatment of premature ejaculation at local clinic. A protruding cavernousal aneurysm about 2 cm in diameter was developed 6 months after surgery and confirmed on penile duplex ultrasonography after PDE5 inhibitor ingestion with visual sexual stimulation. We have observed the lesion every month and found there was slight enlargement for the last 3 months without any other symptoms. We performed cavernosoplasty under the genereal anesthesia. There was a round cavernosal aneurysm on the left side of penile mid-shaft about 4cm in diameter after artificial erection with intracavernosal saline injection. We prevented cavernosal protrusion by covering the aneurismal surface with bovine pericardium patch (Supple Peri-GuardⓇ). There was no side effect for 6 months postoperatively. This is an unusual type of complication of dorsal penile neurectomy. | 비뇨기과학 | null | kci_detailed_000252.xml | |||
ART001441927 | oai_dc | Tadalafil이 뇌 허혈 유발 모래 쥐의 운동 피질에서 세포 사멸에 미치는 영향 | Effects of Tadalafil on the Cerebral Ischemia-induced Apoptotic Neuronal Cell Death in Motor Cortex of Gerbils | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"고일규(한서대학교); 김성은(경희대학교); 김동현(경희대학교); 김태운(경희대학교); 김보균(경희대학교); 신말순(경희대학교); 김창주(경희대학교); 나용길(충남대학교); 주관중(성균관대학교); 김계환(가천의과학대학교)"
] | Purpose: Cerebral ischemia leads to neuronal cell death, and eventually causes neurological impairments. Tadalafil is a long-acting phosphodiesterase type-5 (PDE-5) inhibitor, and it has been used for the treatment of erectile dysfunction. In the present study, we investigated whether tadalafil has the protective effect on apoptotic neuronal cell death in the motor cortex following transient global ischemia in gerbils.
Materials and Methods: For this study, Mongolian gerbils were used for the experimental animals, and transient global ischemia was induced to the gerbils by occlusion of both common carotid arteries for 7 min. Gerbils were randomly divided into five groups (n=8 in each group): the sham-operation group, the cerebral ischemia-induced group, the cerebral ischemia-induced and 0.1 mg/kg tadalafil-treated group, the cerebral ischemia-induced and 1 mg/kg tadalafil-treated group, the cerebral ischemia-induced and 10 mg/kg tadalafil-treated group. Tadalafil-treated groups received tadalafil orally once a day for a 7 consecutive days, starting one day after surgery. Terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay and immunohistochemistry for caspase-3 were performed for the detection of apoptotic neuronal cell death in the motor cortex.
Results: The number of TUNEL-positive cells was 21.45±3.69/section in the sham-operation group, 771.66± 97.25/section in the cerebral ischemia-induced group, 688.44±81.35/section in the cerebral ischemia- induced and 0.1 mg/kg tadalafil-treated group, 295.66±36.34/section in the cerebral ischemia-induced and 1 mg/kg tadalafil-treated group, and 198.47±25.25/section in the cerebral ischemia-induced and 10 mg/kg tadalafil-treated group. In the present results, induction of ischemic injury increased apoptotic neuronal cell death in the motor cortex of gerbils. However, tadalafil treatment suppressed the cerebral ischemia-induced apoptotic neuronal cell death in the motor cortex as dose-dependently.
Conclusions: Here in this study, we showed that tadalafil has protective effect on the cerebral ischemia-induced apoptotic neuronal cell death, and thus this drug may facilitate the recovery following ischemic cerebral injury. | 비뇨기과학 | null | kci_detailed_000252.xml | |||
ART001441929 | oai_dc | 만성 간접흡연이 쥐의 질 조직에서 TGF-β1과 eNOS의 발현에 미치는 영향 | Influences of Chronic Indirect Cigarette Smoking on the Expression of TGF-β1 and eNOS in Rat Vagina | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"김선옥(전남대학교); 이현숙(전남대학교); 오경진(전남대학교병원); 안규윤(전남대학교); 박광성(전남대학교)"
] | Purpose: The objectives of this study were to evaluate the effects of chronic indirect cigarette smoking on vaginal blood flow and on histological change in a rat model.
Materials and Methods: Female Sprague-Dawley rats (12 weeks old, n=40) were devided into smoking and control group. For the exposure to passive smoking, the rat, in plastic enclosure, had a constant influx of cigarette smoke using a smoking generator for 8 weeks in smoking group. The experimental group was exposured to cigarette smoke for 1 hour, twice a day, daily for 8 weeks. Vaginal blood flow was measured by laser Doppler flowmeter. Serum estrogen concentration was measured using competitive radioimmunoassay. Immunohistochemistry and western blot analysis was done to observe the expression of TGF-β1 and e-NOS.
Results: Mean vaginal blood flow (ml/min/100g tissue) significantly decreased in smoking group (13.4±1.6) compared to control (19.6±5.9)(p<0.05). The estimated concentration of serum estradiol (pg/ul) was similar between smoking (1.1±0.8) group and control (1.1±0.3) group. Vaginal histology of the cigarette smoking group was similar to the control. In the cigarette smoking group, the immunoreactivity of TGF-β1 increased in the smooth muscle and fibroblasts. The protein expression of TGF-β1 was increased in the smoking group (p<0.05). There was no significant differences in expression of e-NOS between two groups.
Conclusions: A chronic indirect exposure to cigarette smoke significantly reduces vaginal blood flow and appears to cause vaginal tissue fibrosis in the female rat model. This suggest that cigarette smoking has adverse effects on female sexual functions and may cause sexual arousal disorder in women. | 비뇨기과학 | null | kci_detailed_000252.xml | |||
ART001441684 | oai_dc | 전립선특이항원치 4.0ng/ml 이상인 환자에서 전립선용적과 나이에 따른 전립선암의 발견율 | Prostate Cancer Detection Rate According to Prostate Volume and Age With PSA Levels of above 4.0ng/ml | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"윤병일(가톨릭대학교 의과대학 비뇨기과학교실); 김수진(가톨릭대학교 의과대학 비뇨기과학교실); 조혁진(가톨릭대학교); 홍성후(가톨릭대학교); 손동완(가톨릭대학교); 이지열(가톨릭대학교); 황태곤(가톨릭대학교); 김세웅(가톨릭대학교)"
] | Purpose: We retrospectively investigated the changes of prostate cancer detection rate according to patients prostate volume, age with prostate-specific antigen (PSA) levels of above 4.0ng/ml.
Material and Methods: Data were collected from 663 patients who underwent 10 core prostate biopsy for elevated PSA above 4.0ng/ml. The biopsy-proven cancer patient group was compared to the non-cancer patient group according to age, PSA, prostate volume and PSAD. Prostate cancer detection rate was calculated according to prostate volume (less than 40 vs 40 or more 40ml) and age (less than 60, 60-69, 70-79, 80 or more years old). Also we compared prostate cancer detection rate according to PSA levels (4-10 vs 10-20ng/ml).
Results: Among the 663 patients who underwent prostate biopsy, prostate cancer was detected in 134 patients (20.2%). There were no stastically difference in mean age, mean prostate volume, and mean PSAD except mean PSA (13.9 vs 11.9ng/ml) between cancer and non-cancer groups. The cancer detection rate in small prostate was significantly higher than large prostate (23.5% vs 16.0%). The cancer detection rate was significantly increased with age: from 14.5% for below 60 year-old patients to 30.3% for the 80 or more year-old patients. There was no significant difference in cancer detection rate between the two PSA groups (19.0 vs 20.5%).
Conclusion: Prostate cancer detection rate was higher in old patients and patients with small prostate volume. The older age group and the patients with small prostate volume was considered as the important factors to decide whether biopsy of prostate is needed. | 비뇨기과학 | null | kci_detailed_000252.xml | |||
ART001441677 | oai_dc | 단일기관의 방사선과와 비뇨기과에서 시행한 경직장 초음파유도하 전립선생검 후 임상적 및 병리적 결과에 대한 고찰 | Prostate Cancer Detection by Transrectal Ultrasound Guided Prostate Biopsy: Urology versus Radiology at a Single Academic Institution | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"윤병일(가톨릭대학교 의과대학 비뇨기과학교실); 김수진(가톨릭대학교 의과대학 비뇨기과학교실); 조혁진(가톨릭대학교); 홍성후(가톨릭대학교); 손동완(가톨릭대학교); 이지열(가톨릭대학교); 황태곤(가톨릭대학교); 김세웅(가톨릭대학교)"
] | Purpose: Many centers rely on radiologists to detect prostate cancer by transrectal ultrasound guided prostate biopsy. In this study we evaluated transrectal ultrasound guided prostate biopsy by radiologist or urologist, and compared prostate cancer detection rate, pathologic results and pain scrore.
Material and Methods: In all, 259 consecutive patients had transrectal ultrasound guided prostate biopsy by one radiologist (group 1) and one urologist (group 2). The indication for prostate biopsies were a raised or rising prostate specific antigen (PSA) level or abnormal digital rectal examination (DRE). All data were collected prospectively.
Results: Both group showed comparable demographic data in age, PSA, prostate volume. But pain score showed higher in urologist group (p<0.05). Prostate cancer was detected in 73 patients (28.1%). Radiologist detected prostate cancer in 38 patients (29.2%) and urologist detected prostate cancer in 35 patients (27.1%) (p=0.70). Both groups showed comparable cancer detection rates in PSA of <4, 4-10 and >10 ng/ml. Both groups had similar Gleason score (6.8±0.7 vs 6.7±0.8) and number of cancer cores (3.0±1.7 vs 3.9±2.3). Group 1 showed significantly low visual analogue pain scale compared with Group 2 (2.9±1.9 vs 4.0±2.1)(p<0.05).
Conclusion: Transrectal ultrasound guided prostate biopsy showed equally reliable datas whether performed by radiologist or urologist. The urologist can effectively perform transrectal ultrasound guided prostate biopsy like radiologist in detecting prostate cancer. Also we recommend to perform anesthesia to relieve pain before prostate biopsy and furthermore future studies with more patients with more datas are needed. | 비뇨기과학 | null | kci_detailed_000252.xml | |||
ART001441652 | oai_dc | 조루증과 선택적 세로토닌 재흡수 억제제 | Selective Serotonin Reuptake Inhibitors for the Treatment of Premature Ejaculation | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"한창수(고려대학교)"
] | Premature ejaculation (PE) affects the 20∼30% men among general population regardless of their age. PE may be classified as lifelong (primary) or acquired (secondary) type. Diagnosis of PE is mainly based on subjective complaints of sexual symptoms. Recently proposed diagnostic system of PE is based on many aspects; intravaginal ejaculatory latency time (IELT), control over ejaculation, stress and interpersonal difficulty according to the PE problem.
Standard treatment of lifelong PE is mainly pharmacotherapy. Among many treatment options, selective serotonin reuptake inhibitors (SSRIs) are recommended for off-label use by American Urologic Association and International Consultation on Sexual Medicine. SSRIs were reported to improve the PE symptom by lengthening IELT. However, daily intake of SSRIs often increases the possibility of adverse effects, such as nausea, diarrhea, loss of libido, and even erectile dysfunction. Recently, dapoxetine hydrochloride, newer SSRI with short half life, was tailored to target the PE. Dapoxetine was proved its efficacy on PE over placebo.
Clinicians should keep in mind that the sexual dysfunction can be the primary complaints or the results of the intake of antidepressants at the same time. | 비뇨기과학 | null | kci_detailed_000252.xml | |||
ART001441648 | oai_dc | Cell-based Approaches for Treating Erectile Dysfunction | Cell-based Approaches for Treating Erectile Dysfunction | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"배재현(고려대학교); James J. Yoo(Wake Forest University)"
] | Patients with erectile dysfunction (ED) often lose self-esteem, leading to severe psychological impairment. Although many forms of ED can be corrected with currently available therapeutic measures, several types of ED and its associated conditions may not be readily treated. Recently, the concept of cell transplantation has been applied to address ED with the goal of restoring normal anatomical tissue configuration and erectile function. This article provides an overview of the fundamental principles of these cell-based approaches and presents a framework that can be used to interpret current and future studies as well as to encourage further research into cell-based therapies. | 비뇨기과학 | null | kci_detailed_000252.xml | |||
ART001441666 | oai_dc | 음경골절의 가장 좋은 치료법은? 34명의 보존적 치료와 수술적 치료 경험의 비교 | What is the best Treatment of Penile Fractures? Conservative or Surgical?: Experience in 34 cases | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"윤상진(가천의과학대학교); 박호기(가천의과학대학교); 정한(가천의과학대학교); 주관중(성균관대학교); 김계환(가천의과학대학교)"
] | Purpose: Penile fracture is described as a traumatic rupture of the tunica albuginea because of blunt injury of an erect penis. In this study, we aimed to compare conservative and surgical treatment modalities.
Materials and Methods: We retrospectively reviewed the medical records of 34 patients who visited our hospital with penile fracture and two treatment modalities were compared: conservative (Group I) and surgical (Group II). The five men who refused surgical treatment were treated conservatively, and the other 29 patients underwent surgical treatment.
Results: The most common cause of fracture was sexual intercourse (21/34, 61.8%). The most common sites of fracture were the right (67.6%), ventral (67.6%), and proximal (47.1%) parts of the penis. In Group II, only complication was painful erection (2/29, 6.9%), whereas in group I, 80% (4/5) suffered complications such as wound infection, painful erection, penile nodules with curvature, and erectile dysfunction. All patients treated with surgery successfully recovered without erectile dysfunction.
Conclusions: Because surgical management gives excellent results, shorter hospitalization, less morbidity, surgical treatment is more effective approach than conservative treatment. | 비뇨기과학 | null | kci_detailed_000252.xml | |||
ART001441932 | oai_dc | 성인에서 발견된 Cowper's gland의 낭성확장 | Cowper's Syringocele in an Adult | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"박지성(부산대학교); 박창수(부산대학교병원); 박현준(부산대학교); 박남철(부산대학교)"
] | Cowper's syringocele is cystic dilatation of the main duct of Cowper's glands. Cowper's syringocele is usually diagnosed in male infants and children and is rarely found in adults. We present a case of Cowper's syringocele causing lower abdominal discomfort in an adult male.
| 비뇨기과학 | null | kci_detailed_000252.xml | |||
ART001505293 | oai_dc | 정관복원술에 대한 건강보험 적용의 영향 분석 | Effects of Health Insurance Coverage for Vasovasostomy | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"권대현(영남대학교 의과대학 비뇨기과학교실); 배장호(영남대학교); 송필현(영남대학교 의과대학 비뇨기과학교실); 김현태(영남대학교); 문기학(영남대학교)"
] | Purpose: In early 1980s, vasectomy was performed in more than 10 thousand men of reproductive age annually without cost as a South Korean government policy of birth control, but because the policy has been converted to encouraging childbirth since July 2004, vasovasostomy is now covered by national health insurance. We investigated the effect of national health insurance coverage of vasovasostomy.
Materials and Methods: From August 1997 to June 2009, a total of 117 patients who underwent vasovasostomy were enrolled in this study. We divided the patients into two groups. The 63 patients undergoing the procedure before national health insurance coverage were included in group A, and the other 54 patients, who underwent the procedure after insurance coverage began, were classified into group B. The two groups were compared according to age, spouse's age, time since vasectomy, number of children at the time of vasectomy, occupation, educational attainment, religion, and the reason for vasovasostomy.
Results: The average number of cases of vasovasostomy was almost 3 times higher after insurance coverage was introduced, at 2.3 cases per month. The average spouse's age was significantly higher in group B than group A (35.2±4.8 vs. 32.2±3.5, p=0.012). Time since vasectomy was shorter in group B than group A (5.7±4.7 years vs. 8.9±5.0 years, p=0.001). Number of children at the time of vasectomy showed no significant difference between group A and group B, at 1.7±0.7 and 1.6±0.8 respectively. Cross tabulation analysis of occupation, educational status, religion, and the reason for vasovasostomy showed no significant difference. The patency rate was significantly higher in group A than group B (87.3% vs. 90.7%, p=0.012), but there was no significant difference in pregnancy rate.
Conclusions: A significant increase was seen in patency rate, but not in pregnancy rate, after insurance coverage. However, further follow up will show us that a rise in the patency rate promises positive effects on the rise of pregnancy rate. We suggest that insurance coverage for vasovasostomy has encouraged an increase in births. | 비뇨기과학 | null | kci_detailed_000252.xml | |||
ART001505194 | oai_dc | Practical Tip for Management of Nocturia | Practical Tip for Management of Nocturia | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"오미미(고려대학교); 문두건(고려대학교)"
] | The understanding of nocturia has been much changed in last decade. Recently, nocturia has been recognized as a separate clinical entity within the lower urinary tract symptom complex. The pathophysiology of nocturia is multifactorial and can be complex and its cause remains unclear in a significant number of patients. Although the successful introduction of DDAVP to decrease nocturnal urine output in severe nocturia resistant to conventional treatment demonstrated new perspectives in management of nocturia, the primary treatment modality must be based on the disease. We reviewed the definition and etiologies of nocturia, offering the current diagnostic procedures and standards of care and we suggest practical tip for the management of nocturia. | 비뇨기과학 | null | kci_detailed_000252.xml | |||
ART001505284 | oai_dc | 남성갱년기증상과 혈중 총테스토스테론의 일중변동이 소실된 남성에서의 남성호르몬보충요법 | Testosterone Replacement in Men with Late-onset Hypogonadism Symptoms and Loss of Diurnal Rhythm of Total Testosterone | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"김은탁(을지의과대학교); 이종현(을지대학교 의과대학); 정지훈(을지대학교 의과대학); 조현욱(을지대학교 의과대학 을지대학병원 비뇨기과학교실); 주현택(을지대학교 의과대학 을지대학병원 비뇨기과학교실); 박진성(을지대학교); 우승효(을지대학교); 김대경(을지대학교)"
] | Purpose: It is known that the loss of diurnal rhythm of testosterone by age is related to late-onset hypogonadism (LOH). Currently testosterone replacement therapy (TRT) has been recommended only in men with hypogonadism. We evaluated the effectiveness and safety of TRT for men with LOH symptoms and the loss of diurnal rhythm of total testosterone but normal values of total testosterone.
Materials and Methods: We enrolled 62 patients in whom the difference in testosterone between morning and evening was lower than 108 ng/dl, whose morning values were higher than 300 ng/dl, and who were diagnosed with LOH using the Androgen Deficiency in Aging Male (ADAM) questionnaire. Among the 62 patients enrolled, 44 completed the daily application of 1% testosterone gel or the intramuscular injection of long-acting testosterone undecanoate for the full 20-week period. We compared the data at baseline, and the 8th and 20th week using the Aging Males' Symptoms (AMS) scale, the International Index of Erectile Function (IIEF)-15, the International Prostate Symptoms Score (IPSS), and the serum levels of total testosterone, prostate specific antigen (PSA), complete blood cell count (CBC), and lipid profile.
Results: The mean age was 54.9±7.2 years. Subjects main symptoms were sexual dysfunction and decrease of ejaculate volume. AMS scales before and after TRT were 41.3±18.5 and 35.8±19.7 (p＜0.05). IIEF total scores before and after TRT were 29.7±13.7 and 38.9±17.4 (p＜0.001). However, 18 patients (40.9%) were not satisfied with TRT and only 11% were fully satisfied. Total testosterone and estradiol were higher after TRT but the other values had not changed. The most common adverse event (27.3%) was erythrocystosis (18.2%).
Conclusions: TRT could induce total testosterone to reach the mid-normal level and was relatively effective for aging male symptoms and sexual function. It is essential for physician to inform patients about potential adverse events and the low satisfaction rate associated with TRT even though TRT has generally been effective. | 비뇨기과학 | null | kci_detailed_000252.xml | |||
ART001505215 | oai_dc | 쥐에서 생체이식 방광용적센서를 활용한 실시간 방광용적의 측정 | Measurement of Bladder Volume Using an Implantable Volume Sensor in Rats | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"이동섭(가톨릭대학교); 김수진(가톨릭대학교 의과대학 비뇨기과학교실); 손동완(가톨릭대학교); 유제모(가톨릭의대); 최범규(서강대학교); 이문규(서강대학교); 이승준(서강대학교 기계공학과); 김세웅(가톨릭대학교)"
] | Purpose: Real-time monitoring of urinary bladder volume can not only provide information on urinary bladder function more precisely in laboratories and in the setting of intravesical pressure monitoring, but can also help areflexic neurogenic bladder patients have notice of the timing for optimal urination to prevent secondary complications. Thus we introduce a new implantable bladder volume monitoring device and its usefulness.
Materials and Methods: Ten male Sprague-Dawley rats were used under intraperitoneal anesthesia. Two microelectrodes produced by a micro-electrical-mechanical systems (MEMS) process were stitched onto each side wall of the urinary bladder and 25 G needles were inserted through the bladder dome. The distances between two microelectrodes converted from capacitances recorded by LCR meter were monitored in real-time during cystometry. Urinary bladder volume was estimated with its shape approximated as a sphere.
Results: Estimated bladder volume correlated well statistically with infused volume in (p＜0.05 regression analysis). Since the urinary bladder was filled with over 0.6 cc normal saline in each rat, estimated urinary volume was not different than infused saline volume (p＞0.05, repeated measures ANOVA).
Conclusions: In our animal model, an implantable volume-monitoring device produced reliable data. Therefore, we expect that it should be an excellent tool for detecting urinary bladder volume and producing more accurate and useful information during urodynamic laboratory studies with small animals. Furthermore, we expect that this study will be the foundation of research for the clinical application of bladder volume monitoring devices to areflexic neurogenic bladder patients. | 비뇨기과학 | null | kci_detailed_000252.xml | |||
ART001505218 | oai_dc | 방광외벽에 대한 영구적 생체이식장치의 코팅물질로서 Parylene-C의 생체적합성연구 | Biocompatibility of Parylene-C as a Coating Material of Implantable Bladder Volume Sensor | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"이동섭(가톨릭대학교); 김수진(가톨릭대학교 의과대학 비뇨기과학교실); 손동완(가톨릭대학교); 최범규(서강대학교); 이문규(서강대학교); 이승준(서강대학교 기계공학과); 김세웅(가톨릭대학교)"
] | Purpose: Development of an implantable bladder volume sensor that could reduce complications and improve the quality of life for neurogenic bladder patients is assignment task that falls in the field of urology. Nevertheless, there is lack of research on whether biomaterials are biocompatible to the urinary bladder or not. Polyethylene glycol (PEG), polydimethylsiloxane (PDMS) and parylene-C are well known biocompatible materials in other fields of medicine. Because PEG is biodegradable and PDMS has a relatively low affinity to substrate with less durability than parylene-C, we evaluated the biocompatibility of parylene-C to the urinary bladde,r comparing of it to PEG and PDMS.
Materials and Methods: Nine rabbits were classified into three groups. Coin shaped aluminum substrates were affixed onto the external wall of the urinary bladder in each rabbit. At this point, the three rabbits which had substrates coated with PEG were assigned to group 1, those with PDMS were assigned to group 2 and those with parylene-C were assigned to group 3. In each group, one rabbit was sacrificed at one week, another rabbit was sacrificed at two weeks and the other rabbit was sacrificed at four weeks. At each time microscopic evaluation was done. To detect macrophages, we used fluorescence microscopy and applied MAC 387 staining.
Results: At one week, macrophage accumulation was observed on the external surface of the urinary bladder adjacent to the device no matter which material was used as a coating, but it had almost disappeared by four weeks. In addition, the inflammatory reaction was limited at the external surface of the urinary bladder, and did not expand into the muscular layer.
Conclusions: With respect to biocompatibility, there was no difference among the three biomaterials. With its characteristics of durability and easy affinity regardless of the type of substrate, parylene-C would make an excellent coating material for a bio-device implantable into the urinary bladder. | 비뇨기과학 | null | kci_detailed_000252.xml | |||
ART001505297 | oai_dc | 복강경 정계정맥류 결찰술의 의의 | Significance of Laparoscopic Varicocelectomy | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"이명진(국립경찰병원 비뇨기과); 조승훈(국립경찰병원 비뇨기과); 최재영(국립경찰병원 비뇨기과); 김성빈(국립경찰병원 비뇨기과); 이승태(국립경찰병원 비뇨기과); 민승기(국립경찰병원 비뇨기과)"
] | Purpose: The best option for varicocele treatment is controversial. We evaluate our experience using laparoscopic varicocelectomy & inguinal varicocelectomy, and then compared the two methods. We started this study to find the best treatment for varicocele patients.
Materials and Methods: Between July 2002 and July 2008, 168 cases (Group I) were treated with laparoscopic varicocelectomy and 157 cases (Group II) were treated with the inguinal approach. We assessed the two methods according to operative time, hospital stay, recurrence rate, complication rate, and cost effectiveness.
Results: The mean operative time was 30.2±10.9 min for laparoscopic varicocelectomy and 62.6±13.3 min for inguinal varicocelectomy (p＜0.05). The recurrence rate was 2% for laparoscopic varicocelectomy and 8% for inguinal varicocelectomy (p＞0.05). The complication rate was 10.7% for laparoscopic varicocelectomy and 12.7% for inguinal varicocelectomy (p＞0.05). The cost of laparoscopic varicocelectomy was 401,870 won, but inguinal varicocelectomy was 256,480 won (p＜0.05).
Conclusions: The laparoscopic varicocelectomy required a shorter operative time but no superior outcomes compared to inguinal varicocelectomy. The laparoscopic approach cannot be replaced with the routine open approach but it is thought to be worth consideration in selective cases. | 비뇨기과학 | null | kci_detailed_000252.xml | |||
ART001505314 | oai_dc | Corporeal Fibrosis and Erectile Dysfunction as Sequelae of Unrepaired Penile Blunt Trauma | Corporeal Fibrosis and Erectile Dysfunction as Sequelae of Unrepaired Penile Blunt Trauma | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"Dae Jin Jo(Department of Urology, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Chang); 류동수(성균관대학교); So Jun Yang(Department of Urology, Yeungnam University College of Medicine, Daegu)"
] | Penile fracture is an injury caused by the rupture of the tunica albuginea. We report an uncommon case of penile fracture with corporeal fibrosis and erectile dysfunction in a 45-year-old man who sustained a straddle injury to the erect penis. He presented with palpable plaque in the bilateral proximal corpora cavernosa and markedly decreased erectile rigidity at the distal side of the plaque. Exploration and excision of the penile plaque were performed. The patient partially recovered erectile function after surgery and administration of phosphodiesterase-5 inhibitor. | 비뇨기과학 | null | kci_detailed_000252.xml | |||
ART001505307 | oai_dc | 음경에 Methamphetamine 주사 후 발생한 Fournier Gangrene | A Case of Fournier Gangrene after Penile Methamphetamine Injection | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"문홍상(한양대학교); 이장현(한양대학교 의과대학 성형외과학교실); 최홍용(한양대학교); 박해영(한양대학교)"
] | Fournier gangrene is a fulminant infection of the genitalia, perineum, or abdominal wall. It is a life threatening progressive disease that requires aggressive surgical therapy and broad spectrum antibiotic treatment. We present one case of Fournier gangrene after penile methamphetamine injection. | 비뇨기과학 | null | kci_detailed_000252.xml | |||
ART001505304 | oai_dc | 하복부 지방과 유경피판으로 외음부 동맥을 이용한 음경확대술의 경험 | Penile Augmentation Using Superficial External Pudendal Artery Pedicle and Adipose Tissue | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"길명철(동남권원자력의학원 비뇨기과); 김두홍(동아대학교 의과대학 비뇨기과학교실); 정세일(동아대학교); 황경원(동아항노화연구소); 정재일(동아대학교 자연과학대학 수학과)"
] | Purpose: Many men are to some degree unsatisfied with the size of their penis, whether it is normal in size and appearance or not. We report a novel surgical technique for penile augmentation using a superficial external pudendal artery pedicle.
Materials and Methods: In total, 8 patients underwent penile augmentation from March 2003 to February 2004. Their mean age was 37.3 years. Five patients were unsatisfied about the size of their penis, and three patients had complications after insertion of foreign material. This penile augmentation technique was developed by using a low abdominal fat-flap where blood is supplied from the external pudendal artery. Spinal or epidural anesthesia was done during the operation, and the fat-flap was elevated and transpositioned to the site of lesion.
Results: All cases of patients were performed successfully by autografting using adipose tissue where blood flow was supplied from the external pudendal artery. There were no complications except one case of hematoma after the operation. The mean operative time was 80 min. The mean follow-up period after operation was about 6 months and all patients had a normal sexual life and no voiding dysfunctions.
Conclusions: This novel surgical technique has several advantages. First, reconstruction without skin necrosis was possible even though the defect was large, because the blood supply was favorable. Second, there was no size limitation in augmentation with dermoplasty. Third, there was no evidence of atrophy of the flap. | 비뇨기과학 | null | kci_detailed_000252.xml | |||
ART001505288 | oai_dc | 테스토스테론결핍증후군 남성에서 경구용 테스토스테론제와 경피용 테스토스테론 겔의 효과 비교 | Oral Testosterone Undecanoate Versus Transdermal Testosterone Gel for the Treatment of Testosterone Deficiency Syndrome: A Retrospective Comparative Study | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"박민구(고려대학교); 정승민(고려대학교 의과대학 비뇨기과학교실); 안순태(고려대학교 의과대학 비뇨기과학교실); 강재일(고려대학교 의과대학 비뇨기과학교실); 신수환(고려대학교 의과대학 비뇨기과학교실); 박태용(고려대학교 의과대학 비뇨기과학교실); 배재현(고려대학교); 김제종(고려대학교); 문두건(고려대학교)"
] | Purpose: Oral testosterone undecanoate and transdermal testosterone gel are the testosterone formulas widely prescribed as hormonal replacement for tesosterone deficiency syndrome (TDS) in male patients. We evaluated the changes in serum testosterone level and the effects of these medicines.
Materials and Methods: The medical records of 162 patients who were diagnosed with TDS based on serum testosterone (＜2.55 ng/ml) and prescribed testosterone formula were analyzed retrospectively. In the 111 patients of group I, tablets of oral testosterone undecanoate were initially given. If the follow up serum testosterone level had not increased enough, the dosages were increased up to 6 tablets. In the 51 patients of group II, one pack of transdermal testosterone gel (5 gm) daily without dosage adjustment was prescribed. Statistical analysis was done to identify any correlations among age, initial and final aging male’s symptoms scale (AMS) score, initial, peak and final testosterone level, and duration of therapy.
Results: The mean ages of group I and II were 53.4±14.5 and 55.2±11.9, respectively (p＞0.05). The initial and final testosterone levels of the two groups were not significantly different. However, the peak level during treatment was significantly higher in group II (p＜0.05). The maximal increment of testosterone level was also significantly higher in group II. Initially, group II reached its peak testosterone level earlier than group I. The final serum levels were not significantly different after adjustment of dosages in group I. Testosterone replacement significantly decreased the AMS scales in both groups.
Conclusions: Both oral testosterone undecanoate and transdermal testosterone gel improved the serum testosterone level and symptom score for those with TDS. Transdermal testosterone gel may reach the peak serum testosterone level faster than oral testosterone undecanoate. Large prospective studies are required to assess the precise role of testosterone replacement therapy. | 비뇨기과학 | null | kci_detailed_000252.xml | |||
ART001505212 | oai_dc | 흰쥐 당뇨모델의 음경해면체에 이식된 인간 중간엽줄기세포 변화의 자기공명영상 추적관찰 | Monitoring Transplanted Human Mesenchymal Stem Cells in the Penile Cavernosal Tissues of Streptozotocin-induced Diabetic Rats Using Molecular Magnetic Resonance Imaging | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"송윤섭(순천향대학교); 윤종현(순천향대학교 의과대학 비뇨기과학교실); 두승환(순천향대학교); 양원재(순천향대학교); 김정훈(순천향대학교); 최동호(순천향대학교); 김숙자(순천향대학교); 정희정(순천향대학교); 원종호(순천향대학교)"
] | Purpose: A molecular magnetic resonance (MR) imaging technique using superparamagnetic iron oxide (SPIO) nanocrystals was developed for monitoring stem cells noninvasively. This study was performed to investigate whether the presence of transplanted human mesenchymal stem cells in the penile cavernosum of a diabetic rat model could be evaluated noninvasively using molecular MR imaging.
Materials and Methods: SPIO nanocrystals (Feridex; AMI, Cambridge, USA) were transferred to human mesenchymal stem cells (hMSCs) using GenePORTER. The SPIO-transferred hMSCs were examined with Prussian blue staining. SPIO-labeled hMSCs were transplanted to the penile cavernosum of a diabetic rat model and MR images were examined in vivo using 1.5 T MR.
Results: SPIO was transferred to hMSCs successfully. MR signal intensity at the areas of the SPIO-transferred hMSCs decreased in the penile cavernosum of the diabetic rat model. SPIO particles were confirmed in the transplanted penile cavernosum with Prussian blue staining.
Conclusions: The SPIO-labelled hMSCs in the penile cavernosum of a diabetic rat model can be monitored noninvasively using molecular MR imaging. | 비뇨기과학 | null | kci_detailed_000252.xml | |||
ART001505190 | oai_dc | 전립선비대증과 성기능장애 | Benign Prostatic Hyperplasia and Sexual Dysfunction | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"조인래(인제대학교)"
] | Lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH) and declines in male sexual function are common manifestations of aging, and have been associated with each other in a number of clinical and epidemiological studies. Erectile and ejaculatory function declines with age-adjusted LUTS severity as well as age itself. Although urinary symptoms and quality of life may improve with BPH therapy, the resulting effects on sexual function vary by medical or surgical treatment. Alpha-blockers improve sexual function and phosphodiesterase type 5 (PDE5) inhibitors decline LUTS scores. PDE5 inhibitors approved for daily use may represent an important new therapeutic opportunity for men with BPH-LUTS and erectile dysfunction. Larger studies on the combination of an alpha-blocker for BPH and a PDE5 inhibitor are necessary to develop an integrated treatment approach for BPH-LUTS patients with erectile dysfunction. | 비뇨기과학 | null | kci_detailed_000252.xml | |||
ART001505278 | oai_dc | 전립선비대증 환자에서 술 전 전립선특이항원치 4 ng/ml 기준으로 경요도전립선절제술 후에 발생하는 전립선특이항원의 감소치 비교 및 의의 | Comparision of Prostate-specific Antigen Reduction after Performing Transurethral Resection of the Prostate according to a Preoperative Prostate-specific Antigen Value of 4 ng/ml | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"이안구(인제대학교); 조성용(인제대학교); 조인래(인제대학교)"
] | Purpose: We compared prostate-specific antigen (PSA) reduction after performing transurethral resection of the prostate (TURP) according to a preoperative PSA value of 4 ng/ml and analyzed the meaning of elevation of the preoperative PSA value over 4 ng/ml.
Materials and Methods: We investigated the PSA level and prostate volume by transrectal ultrasonography (TRUS), urine flow rate, residual urine volume, and international prostate symptom score (IPSS) preoperatively and at 1 year after performing TURP in 61 clinically diagnosed BPH patients who had lower urinary tract symptoms (LUTS). We enrolled the 61 patients into 2 groups according to their preoperative PSA level relative to 4 ng/ml and compared the PSA reduction ratio (postoperative PSA level/preoperative PSA level), prostate volume reduction ratio, preoperative prostate volume, resected prostate volume, preoperative residual urine volume, preoperative maximal flow rate, and IPSS in each group.
Results: In the preoperative PSA group ≥4 ng/ml, the PSA reduction ratio was significantly lower than the PSA group ＜4 ng/ml and there were significant differences between the two groups in total IPSS, obstructive score, and preoperative maximal urine flow rate but no significant differences in preoperative prostate volume, prostate volume reduction ratio, or resected prostate volume.
Conclusions: Marked PSA reduction after performing TURP was achieved in members of the preoperative PSA group ≥4 ng/ml, who are expected to have more severe bladder outlet obstruction (BOO). | 비뇨기과학 | null | kci_detailed_000252.xml | |||
ART001339882 | oai_dc | Clinical Trial with Tamsulosin and Doxazosin for the Treatment of Premature Ejaculation in Patients with Co-morbid LUTS: a Comparative Study | Clinical Trial with Tamsulosin and Doxazosin for the Treatment of Premature Ejaculation in Patients with Co-morbid LUTS: a Comparative Study | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"홍영권(포천중문의과대학교); 박동수(포천중문의과대학교); 홍재엽(포천중문의과대학교); 정재승(포천중문의과대학교); 이상은(서울대학교); 홍성규(서울대학교); 정성진(서울대학교); 장석흔(분당재생병원); 김재일(분당재생병원)"
] | Purpose: We wanted to evaluate the therapeutic potential of a low dose of tamsulosin, as compared with doxazosin, for the treatment of premature ejaculation in men with lower urinary tract symptoms (LUTS).
Materials and Methods: Ninety-six patients (mean age: 55 years) who had LUTS with premature ejaculation were randomly assigned to receive 0.2 mg of tamsulosin and 4 mg of doxazosin daily for a period of 3 months. Patients were evaluated by taking the medical history, the International Prostatic Symptom Score (IPSS) and the Male Sexual Health Questionnaire (MSHQ) for ejaculatory function. The intravaginal ejaculatory latency time (IELT) measured by the patient’s estimation and the sexual satisfaction ratio of both the partner and patient were investigated twice during the screening period and after treatment. At 3 months later, we assessed the differences in the IPSS score, the MSHQ score, the IELT and the sexual satisfaction ratio between the two groups.
Results: The two α1-adrenoceptor antagonists had significant effects on the IPSS (p<0.05). However, we failed to find a statistically significant difference for each medication and the total MSHQ ejaculatory function score after medication in each group. The IELT was prolonged from 2.7±1.6 to 3.5±1.5 minutes and from 2.9±1.8 to 3.5±1.9 minutes in the tamsulosin and doxazosin groups, respectively. However, there was also no statistically significant difference of the IELT and the sexual satisfaction ratio in either group.
Conclusions: For patients with premature ejaculation and LUTS, 0.2mg of tamsulosin improved the voiding symptoms, as assessed with the IPSS, as 4mg of doxazosin did, but neither medication seemed to be effective for the treatment of premature ejaculation. | 비뇨기과학 | null | kci_detailed_000252.xml | |||
ART001339885 | oai_dc | 수면 중 발생한 재발성 음경지속발기증 | Stuttering Priapism happened in Sleep | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"송현동(인제대학교); 조인래(인제대학교); 이안구(인제대학교); 조성용(인제대학교)"
] | Priapism is an abnormal persistent penile erection that continues for more than 4 hours, without sexual stimulation according to the definition of the AUA (American Urological Association) guideline on the management of priapism. It was relatively rare in the past but has been increasing in the incidence since the advent of pharmacological agents. Stuttering priapism is a recurrent form of ischemic priapism and its treatment goal is to prevent the recurrences of priapism and resultant erectile dysfunction. We present the case of a patient who took tadalafil and thereafter had idiopathic recurrent episodes of ischemic priapism during the sleep and we show several treatment options of stuttering priapism with review of recent related articles.
| 비뇨기과학 | null | kci_detailed_000252.xml | |||
ART001339876 | oai_dc | 정관복원술 환자의 특성과 출산결과 | The Patient Characteristics and Birth Outcomes of Vasovasostomy | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"김준석(전남대학교); 박광성(전남대학교); 김영중(전남대학교); 남덕현(전남대학교); 신보성(전남대학교)"
] | Purpose: The purpose of this study was to investigate the characteristics of the patients who had undergone vasovasostomy and to analyze the reasons for an increase in the number of these operations.
Materials and Methods: From January 1999 to April 2007, 105 patients were analyzed by examining their medical records and conducting telephone surveys. The patients were divided into two groups before and after insurance payments for a vasovasostomy. Analysis of the differences between the two groups was performed by grouping the patients who had a vasovasostomy before July 2004 and those who had a vasovasostomy after July 2004.
Results: Among the 105 patients, 35 patients (0.58/month) had a vasovasostomy before receiving their insurance payment. However, the number of operations increased by more than 4 times (70 patients, 2.33/month) after insurance repayment (p<0.05). After the payment, the proportion of patients willing to have a vasovasostomy due to changing their mind increased, whereas the proportion of patients willing to have a vasovasostomy for remarriage and loss of a child decreased (p<0.05). The overall patency and birth rates were 87.6% and 76.1%, respectively (43 boys and 37 girls). Among such factors as the age of the patient and his spouse, the duration of ligation and the presence of seminal fluid and sperm, the duration of ligation was the only factor that showed relevance to the anatomical patency (p<0.05). There were no variables that showed significant relevance to the pregnancy rate.
Conclusions: The main reason of vasectomy reversal was to have another child. The numbers of vasovasostomies were influenced by the medical insurance payment. The duration of ligation affected the anatomical patency rate. The overall patency rate was 87.6% and the birth rate was 76.1% in this study.
| 비뇨기과학 | null | kci_detailed_000252.xml | |||
ART001339877 | oai_dc | 전립선비대증에 대한 경요도 전립선 절제술과 경요도 레이저 전립선기화술의 비교 | A Comparison of Outcomes between Transurethral Resection of the Prostate and High Power Potassium-titanyl-phosphate Laser Vaporization of the Prostate | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"강승철(고려대학교); 박세홍(고려대학교); 윤덕기(고려대학교); 문두건(고려대학교); 함병국(고려대학교); 고기원(고려대학교)"
] | Purpose: Transurethral resection of the prostate (TURP) is the gold standard for the surgical treatment for benign prostatic hyperplasia (BPH), but the procedure’s limitations are its invasiveness and the high prevalence of complications. Photoselective vaporization of the prostate (PVP) using an 80w high power potassium-titanyl-phosphate (KTP) laser has recently been developed as a less invasive treatment. We assessed the efficacy of PVP as an alternative to TURP for the treatment of BPH.
Materials and Methods: The medical records of 324 patients who were surgically treated for BPH from July 2005 to December 2007 were retrospectively reviewed. Among the 324 patients, 190 patients of Group I were treated by TURP and 134 patients of Group II were treated by PVP. Before treatment, assessing the serum PSA level transrectal ultrasound and urodynamic study were done. The primary efficacy parameters were the postoperative international prostatic symptom score and the uroflow parametersat 6 months after the operation. The secondary efficacy parameters were perioperative factors such as the duration of the hospital stay, the operative time and the catheter-indwelling period. Any adverse reactions were monitored.
Results: There was no significant difference in the basal characteristics of the study subjects between both the groups. The primary efficacy parameters, the IPSS, the Qmax and thepostvoid residual urine volume were significantly improved in both groups, but there were no significant differences between both the groups. In group II, the perioperative parameters such as the operation time, the hospitalization day and the catheter-indwelling periodwere significantly shorter than those of group I (p<0.05). But the urethral complications such as urethral stricture, dysuria and bladder neck contracture were more common in group II.
Conclusions: These results suggest that PVP using an 80w high power KTP could be an alternative for TURP in terms of efficacy. For the general, safe use of PVP, PVP should be carefully done until the causes of the urethral complications of PVP are determined. | 비뇨기과학 | null | kci_detailed_000252.xml | |||
ART001339735 | oai_dc | 발기부전 환자와 배우자의 성 태도와 치료에 대한 인식 | Sexual Attitude and Perception on Erectile Dysfunction Treatment among Patients with Erectile Dysfunction and the Patients' Spouses | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"김세철(중앙대학교)"
] | It has generally been assumed that erectile dysfunction (ED) is a shared sexual dysfunction that is distressing
both for the men with ED and for their partners. Many ED men feel discouraged, disappointed or
depressed. An oriental concept that the man has a leading role and full responsibility for sex may cause
the impact of ED to be more serious for men than for women A woman's response to ED will vary depending
on whether or not she desires to have intercourse with her male partner. If the woman desires intercourse,
then she will fine herself frustrated, interpreting he no longer loves her and she will usually be
quite hostile and become depressed. However, in case she is no longer interested in having intercourse
with him, she may be secretly pleased at his sexual dysfunction and do nothing to alter the situation.
Men with ED are reluctant to talk about their sexual problems to their partners mainly because of their
pride and their reluctant to go to hospital due to the belief that ED is a natural process of aging or it is
an occasional symptom with the hope that the problem will get better on its own, and it is not serious
enough to go to the hospital. However, the number of patients seeking medical treatment of ED has increased
since the launch of Viagra. ED treatment improves confidence, it brings a sense of emotional stability
and vitality of life and marital life, and it improves the family and personal relations both for ED
patients and their female partners. | 비뇨기과학 | null | kci_detailed_000252.xml | |||
ART001339842 | oai_dc | 음경보형물의 합병증 | Complications of Penile Prosthesis Implantation | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"박종관(전북대학교)"
] | Penile prosthesis implantation is the best effective method to treat the patient with erectile dysfunction, although this is the most invasive surgery. There are two kinds of the penile prosthesis, which has been used, inflatable and non-inflatable. The implantation of non-inflatable penile prosthesis is easy, less expensive, and has less complication compared with inflatable penile prosthesis implantation. At past, infection and mechanical failure were frequently occurred, however, complication rates included infection and mechanical failures decreased due to mechanical development of penile prosthesis and operative technique at present. Although the rate of complication is low, complications mostly need invasive revision surgery and has higher infection rate than first time implantation. The rate of successful implantation of a semi-rigid rod penile prosthesis and use for coitus is 72% to 92%. 10 year survival rate in the implantation of inflatable penile prosthesis is 68.5% to 74.9%. The three-piece inflatable penile prosthesis implantation has the highest patient satisfaction rates (consistently over 90%). The survival rate should be decreased as time goes by. The more common and important complications are infection, mechanical failure, which include tube broken, corporal crossover of cylinder, corporal and urethral perforation, supersonic transporter (SST) or glans bowing deformity, deep vein thrombosis, migration of reservoir into the abnormal space, reservoir erosion into adjacent viscera, urethral stricture, and penile necrosis. Complications of these penile prosthesis continue to decline, however patient satisfaction rates, tolerability, and longevity continue to increase. We have to concentrate the selection of the patient and penile prosthesis, improvement of surgical technique to provide the highest quality of life for the erectile dysfunction patient, who required surgery.
| 비뇨기과학 | null | kci_detailed_000252.xml | |||
ART001339868 | oai_dc | 당뇨병성 발기부전 환자에서 동반된 심혈관 위험인자들이 발기능 및 치료 효과에 미치는 영향 | The Effect of Cardiovascular Risk Factors on the Patient with Erectile Dysfunction and Diabetes and the Response to Phosphodiesterase Type 5 Inhibitors | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"손동완(가톨릭대학교); 김두배(가톨릭대학교); 송기호(가톨릭대학교); 김세웅(가톨릭대학교); 김성대(가톨릭대학교); 김성인(가톨릭대학교); 김재식(가톨릭대학교)"
] | Purpose: Erectile dysfunction (ED) is a common comorbidity with diabetes mellitus (DM). The goal of this study was to evaluate the effect of cardiovascular risk factors (CVRF) on ED patients with DM and the response to phosphodiesterase type-5 (PDE5) inhibitors.
Materials and Methods: We performed a retrospective study on 32 patients with ED and type II DM. The CVRFs were defined as hypertension, coronary artery disease, hyperlipidemia, smoking and obesity. All the patients were checked for CVRFs and the erectile function was assessed with the International Index of Erectile Function (IIEF) score. Tadalafil (20mg) was taken for 3 months, and then the IIEF score was checked again. The scores of the IIEF-EF, Q3 and Q4 and the number of risk factors were analyzed.
Results: The scores of the IIEF-EF, Q3 and Q4 were higher in the non-risk factor group than that in the risk factor group. After Tadalafil treatment, the score of the group that had less than 1 risk factor was significantly improved, but the score of the group that had more than 2 risk factors showed little change.
Conclusions: To treat ED patients with DM, their cardiovascular risk factors must be assessed. | 비뇨기과학 | null | kci_detailed_000252.xml | |||
ART001339855 | oai_dc | 정계정맥류 흰쥐 모델에서 정계정맥류 유발기간과 고환손상의 연관성 | Correlation Between Duration of Varicocele and Testicular Damage in an Experimental Rat Model | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"박창수(부산대학교); 박현준(부산대학교); 박남철(부산대학교); 남형종(부산대학교)"
] | Purpose: The aim of this study was to evaluate the damage to the testicles caused by a varicocele over time with using an experimental varicocele rat model and by measuring the testicular weight, the status of oxidative stress, the hormonal changes and the degeneration of the tubules.
Materials and Methods: Thirty male Sprague-Dawley white rats, 10 weeks old, weighing 350-360g each, had experimentally induced left varicoceles; 30 rats of the same age were used as a control group. All rats in the varicocele and control groups were sacrificed at 2, 4 and 8 weeks after surgery. The testicular weight, the levels of serum reactive oxygen species, serum testosterone, LH and FSH, as well as the degenerative changes of the tubules were measured. Statistical analyses for comparisons between the two groups were performed using the Mann-Whitney U test; probability values of less than 0.05 were considered significant.
Results: Degenerative changes of the tubules on H-E stain and the testicular weight loss were observed 4 weeks after surgery. There was a significant difference in the serum ROS between the varicocele group and the control group at eight weeks after surgery. However, there were no significant differences found in the serum testosterone, LH or FSH.
Conclusions: The results of this study with using a rat model showed that a varicocele may cause progression of the testicular damage that induced by the varicocele over time. If a further study shows that this damage can be reversed, then there may be a critical period for treatment of men before infertility develops.
| 비뇨기과학 | null | kci_detailed_000252.xml | |||
ART001339862 | oai_dc | PDE5 차단제 비반응군에서 테스토스테론과 PDE5 차단제 병합요법의 효과 | The Efficacy of a Combination of Phosphodiesterase Type 5 Inhibitor and Testosterone Replacement Therapy in Nonresponders to Phosphodiesterase Type 5 Inhibitor Mono-therapy | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"박민구(고려대학교); 박세홍(고려대학교); 김제종(고려대학교); 문두건(고려대학교); 고기원(고려대학교); 함병국(고려대학교)"
] | Purpose: The aim of this study was to evaluate the efficacy of a combination therapy with PDE5 inhibitor and testosterone replacement therapy in erectile dysfunction patients with testosterone deficiency syndrome (TDS) after failure of PDE5 inhibitor mono-therapy.
Materials and Methods: From March 2004 to July 2008, we evaluated 38 men (aged 38 to 69 years) who showed no response to PDE5 inhibitor therapy at the maximal recommended dose and they had testosterone levels less than 350ng/dL. Testosterone replacement therapy (TRT) was subsequently started with injectable testosterone undecanoate (NEBIDOⓇ) or transdermal testosterone (TestogelⓇ) in those patients. They received TRT during an 18-week period. After 14 weeks of TRT alone, PDE5 inhibitor was added to the TRT for an additional 4 weeks. After treatment, we evaluated the patients’ sexual function, which was primarily based on the International Index of Erectile Function (IIEF), and the serum testosterone levels.
Results: All patients showed elevated serum testosterone levels after TRT (range: 212 to 662ng/dl, mean level: 362.19 ng/dl). At week 18, almost all of the men reported improved potency with combination therapy. After treatment, the mean total IIEF score and each sub-domain score were increased significantly compared to the baseline score.
Conclusions: Testosterone replacement therapy combined with PDE5 inhibitor may be beneficial in improving the erectile function in testosterone deficiency syndrome patients with erectile dysfunction and who are unresponsive to PDE5 inhibitor alone. | 비뇨기과학 | null | kci_detailed_000252.xml | |||
ART001339887 | oai_dc | 타다라필 복용 후 발생한 음경지속발기증 1례 | A Case of Tadalafil associated Priapism | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"배장호(영남대학교); 현창호(영남대학교); 송필현(영남대학교); 김현태(영남대학교); 신홍석(대구가톨릭대학교); 문기학(영남대학교)"
] | We report here on a case of priapism that was associated with the use of tadalafil. A 41 year-old-man visited our urology outpatient department with a relapsed erection he’d experienced for 3 days. He had no contributing factors for the priapism. He had taken tadalafil, which was prescribed at a local medical center 3 days previously. After the development of priapism, he first visited the emergency department of other hospital. Aspiration was done and then the priapism was resolved. Yet the priapism recurred 2 days later, andaspiration and other bedside management failed to resolve it. After his arrival to our department, we immediately performed a caverno-glandular shunt with 18-gauge needle and we observed bright reddish-color blood. An intracorporal ephedrine injection and saline irrigation were then done. After that, the patient gradually experienced detumescence. The priapism did not recur during the 2 days of the hospitalization period. At the outpatient follow-up of 3 months later, patient almost recovered to his full erectile function and he had normal sexual activity. | 비뇨기과학 | null | kci_detailed_000252.xml | |||
ART001302617 | oai_dc | 암과 남성불임 | Cancer and Male Infertility | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"서주태(관동대학교); 김태홍(관동대학교 의과대학 제일병원 비뇨기과)"
] | Male infertility and fertility preservation in cancer patients have been frequently discussed. Cancer is not
rare in men, especially young men, and it has several adverse effects on the reproductive organs, such as
the testicles and other endocrine organs, resulting in infertility or subfertility. As cancer treatments improve,
cancer survivors are steadily increasing in number and fertility preservation in young men is becoming
another major concern, separate from the treatment of cancer itself. Simultaneously, the advance of assisted
reproductive techniques (ART) has led to new possibilities for the prevention and treatment of
infertility. This report reviews 1) the impact of cancer on fertility, 2) infertility after cancer therapy, such
as surgery, chemotherapy, and/or radiation therapy, and 3) fertility preservation. | 비뇨기과학 | null | kci_detailed_000252.xml | |||
ART001302768 | oai_dc | 경직장 전립선 생검 후 발생한 감염성 합병증의 위험인자와 배양된 균주의 특징 | Risk Factors of the Infectious Complications and Causative Microorganisms after Transrectal Ultrasound-guided Prostate Needle Biopsy | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"장훈아(고려대학교 의과대학 비뇨기과학교실); 강재일(고려대학교 의과대학 비뇨기과학교실); 배영대(고려대학교 의과대학 비뇨기과학교실); 진명헌(고려대학교); 박재영(고려대학교 의과대학 비뇨기과학교실); 문두건(고려대학교); 윤덕기(고려대학교); 김제종(고려대학교)"
] | Purpose: Transrectal ultrasound-guided prostate needle biopsy (TRUS-PBx) is the standard procedure to diagnose prostate cancer. We evaluated the incidence and risk factors of infectious complications, the species cultured and rates of resistance for antibiotics of microorganism in infectious complications after TRUS-PBx.
Materials and Methods: We retrospectively evaluated the medical records of 742 patients who underwent TRUS-PBx from January 2004 to May 2007. All patients were treated with intravenous ciprofloxacin and oral ciprofloxacin for 1 week after discharge. Patients who presented infectious complications were performed chest x-ray, blood analysis, urine analysis and culture studies.
Results: Among 742 patients, 15 patients (2.0%) developed infectious complications. There were no significant differences between the complication and non-complications groups in age, PSA, prostate volume, nodule, hypoechoic lesion on transrectal sonography and underlying medical diseases. Twelve cases were performed in outpatient department and 3 cases were in operation room and that suggests high frequency of infectious complication when transrectal prostate biopsy is performed in outpatient department (p=0.007). Six kinds of microorganisms were cultivated in 12 patients (1.9%). E. coli (7/12) was most common. Extended-spectrum β-lactamase suggesting nosocomial infection was positive in 3 cases of outpatient department. On logistic regression analysis, urethral catheter indwelling was a significant risk factor increasing infectious complications.
Conclusions: After TRUS-PBx, the rate of severe infectious complications and nosocomial infections were more frequent in outpatient department. And urethral catheter indwelling significantly increased infectious complication rate. So we should sublate the urethral catheter and keep in mind the aseptic technique at outpatient department.
| 비뇨기과학 | null | kci_detailed_000252.xml | |||
ART001302788 | oai_dc | Alfuzosin XL 10mg (UroXatralⓇ)의 올바른 복용법에 대한 환자의 순응도와 이에 영향을 미치는 요인 | Patient Compliance and Associated Factors for Treatment with Alfuzosin XL 10mg (UroXatralⓇ) | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"정태성(순천향대학교); 김윤동(순천향대학교); 이명호(순천향대학교); 송윤섭(순천향대학교); 박영호(순천향대학교); 양원재(순천향대학교)"
] | Purpose: Alfuzosin XL (Sanofi-Aventis, UroXatralⓇ) has to be taken just after a meal for the best efficacy due to its specific pharmacokinetics. We studied patient compliance and associated factors with regard to the correct instructions for taking alfuzosin XL.
Materials and Methods: Alfuzosin XL was prescribed to 62 patients from February to May 2008. At the first visit, we provided a prescription for alfuzosin XL with the instructions to "take one tablet just after dinner once a day". At the second visit, we evaluated patient compliance and the factors that influenced the patient compliance for taking the alfuzosin XL. The physician explained the instructions to the patients. At the third visit, we compared the compliance and associated factors with the results from the first visit.
Results: A total of 50 patients completed the study. After the first visit, twenty one patients (42.0%) were not taking the alfuzosin XL according to the prescription, that is, 20 patients took alfuzosin XL before going to bed, and one patient before meals. (p<0.05) After direct instructions by a physician, 49 patients (98.0%) took the alfuzosin XL correctly. (p<0.001)
Conclusions: Taking alfuzosin XL as prescribed was accomplished in only 58% of patients. When alfuzosin XL is prescribed, the physicians should be aware of the importance of providing instructions directly to patients.
| 비뇨기과학 | null | kci_detailed_000252.xml | |||
ART001302660 | oai_dc | 대사증후군 백서모델에서 음경해면체의 발기능 및 조직학적 변화 | The Changes of the Erectile Function and Histology of the Corpus Cavernosum in a Rat Model of Metabolic Syndrome | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"김성대(가톨릭대학교); 조수연(가톨릭대학교); 손동완(가톨릭대학교); 이동섭(가톨릭대학교); 정문수(가톨릭대학교); 김두배(가톨릭대학교); 김효신(강원대학교); 조용현(가톨릭대학교); 박철휘(가톨릭대학교); 김세웅(가톨릭대학교)"
] | Purpose: We evaluated the changes of the erectile function and histology of the corpus cavernosum in
a rat model of metabolic syndrome.
Materials and Methods: We used male spontaneous hypertensive rats (SHRs) as an experimental group
(n=6) and Wistar-Kyoto rats as a control group (n=6). The SHRs were fed with a high fat diet, but the
Wistar-Kyoto rats were fed with a normal fat diet for 12 weeks. All the groups were then checked for
body weight and various biochemiclal parameters. To investigate penile erection, the intracavernosal pressure
(ICP), mean arterial pressure (MAP) and cGMP level of the corpus cavernosum were recorded for all
the groups. Serial sections of the penis were used to perform Masson's trichrome staining and immunohistochemistry
for determining the TGF-β1 expression.
Results: We confirmed that metabolic syndrome was induced in the experimental group by the significant
difference of the various biochemical parameters. (ED note: For the results of erectile function?
This wasn’t clear.)As a result of erectile function, the ICP/MAP ratios were checked as 51.0±7.5% and
31.0±5.5%, respectively, for the control and experimental groups. So the ICP/MAP ratio of the latter was
markedly decreased compared with the former and the cGMP level of the corpus cavernosum was the
same for both groups. On Masson's trichrome staining, the number of smooth muscle cell was decreased
and the collagen fibers with an irregular, distorted arrangement were increased in the experimental group.
The immunoreactivity for TGF-β1 tended to increase in the experimental group. These histological findings
revealed that fibrosis of the corpus cavernosum occurred in the experimental group.
Conclusions: Our results demonstrate that metabolic syndrome is harmful to erectile function and it
leads to histological changes of the corpus cavernosum according to a rat model of metabolic syndrome | 비뇨기과학 | null | kci_detailed_000252.xml | |||
ART001302631 | oai_dc | 보조생식술 시대에 비뇨기과 의사의 역할 | The Role of Urologist in the Era of Assisted Reproductive Technology (ART) | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"김종현(미즈메디병원)"
] | Because of the success of assisted reproductive technology (ART), many men who have uncorrectable causes of infertility can become biological fathers. However, this robust technology can result in bypassing the evaluation and management of infertile men, and unknowingly transmit genetic disorders into the next generation. In the era of ART, the goals of the evaluation of infertile men are to identify (1) reversible conditions, (2) irreversible causes that may be managed by ART using the male partner’s sperm, (3) irreversible conditions that may not be managed by the above techniques and for which the couple should be advised to pursue donor insemination or adoption, (4) significant underlying medical pathology, and (5) genetic and/or chromosomal abnormalities that may affect either the patient or his offspring. After a proper evaluation, the urologist should attempt to upgrade the infertile man through various medical and/or surgical management. Before ART is performed, genetic counseling is also needed to ascertain the probability of transmission of genetic problems to the next generation by ART. In addition, to improve the success rate of natural conception and ART, the urologist should never cease attempting to get more healthy sperm with a well- preserved nucleus DNA integrity.
| 비뇨기과학 | null | kci_detailed_000252.xml | |||
ART001302804 | oai_dc | Clinical Efficacy and Safety of Long-acting Injectable Testosterone Undecanoate for Treating Patients with Testosterone Deficiency Syndrome | Clinical Efficacy and Safety of Long-acting Injectable Testosterone Undecanoate for Treating Patients with Testosterone Deficiency Syndrome | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"배재현(고려대학교); 유정우(고려대학교병원 비뇨기과학교실); 김제종(고려대학교); 문두건(고려대학교)"
] | Purpose: Long-acting injectable testosterone undecanoate (TU, NebidoⓇ), a new parenteral testosterone preparation, has recently been introduced to avoid frequent injections of the conventional injectable esters. We performed this study to assess the efficacy and safety of long-acting injectable TU in patients who suffer with testosterone deficiency syndrome (TDS).
Materials and Methods: In this prospective, non-controlled single arm trial, a total of 33 patients (a mean age of 55.8±6.4 yrs) with TDS, as defined by serum testosterone levels of less than 3.5 ng/mL, were injected with 1000 mg of TU (4mL/ampule) on day 1, followed by another injection 6 weeks later with follow-up injections 3 months thereafter for a total of 54 weeks. Before and 18 and 54 weeks after the TU injections, the changes of the Aging Males' Symptoms (AMS) scale, the serum total testosterone, the lipid profiles, the CBC, the PSA level, the prostate volume by TRUS and the body mass index (BMI) were compared by Students' paired t-tests. Any adverse effects were also evaluated.
Results: Compared to the pretreatment results, the serum total testosterone level was significantly increased at 18 and 54 weeks (P<0.01), but there was no difference for the serum total testosterone level between weeks 18 and 54, that is, they were stable. The BMI was not significantly decreased at 54 weeks compared to pretreatment. Injectable TU also significantly improved the AMS scores, and especially in the sexual domain (P<0.01). The other data, except the hematocrit, was not significantly changed (P<0.05). Injectable TU did not show a harmful effect on the prostate during the 54 weeks. No patient reported any adverse side effects or events.
Conclusions: Injectable TU effectively elevated the serum total testosterone levels and it maintained stable concentrations during the treatment period. Injectable TU significantly improved the total AMS score, but there were no reported significant changes in the body habitus and lipid profiles. Further large, well-controlled, long-term studies should be done to assess the effect of injectable TU on TDS patients.
| 비뇨기과학 | null | kci_detailed_000252.xml | |||
ART001302840 | oai_dc | 남성호르몬 보충요법에 의해 유발된 적혈구증가증: 장기지속형 주사형 테스토스테론 제제의 합병증 | Polycythemia as a Complication of Long-acting Injectable Testosterone Undecanoate | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"신동식(고려대학교); 고기원(고려대학교 의과대학 비뇨기과학교실); 남상간(고려대학교); 진명헌(고려대학교); 김제종(고려대학교); 문두건(고려대학교)"
] | Polycythemia is a condition in which the red blood cell count is increased due to an inherited or acquired mutation, a physiologic response to hypoxia, autonomous erythropoietin production, or deliberate erythropoietin administration. Higher testosterone levels appear to act as a stimulus for erythropoiesis and testosterone replacement therapies have rarely been reported as causes of polycythemia. We report here a case of a 51-year-old man with polycythemia that was caused by long-acting testosterone undecanoate (NebidoⓇ).
| 비뇨기과학 | null | kci_detailed_000252.xml | |||
ART001302641 | oai_dc | 발기 능력과 사정에 관한 문화적 관점 | A Cultural Perspective of Erectile Capacity and Ejaculation | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"윤가현(전남대학교)"
] | A man should control his ejaculation until a woman has an orgasm if the couple desires to achieve mutual orgasms during sexual intercourse. In male-oriented traditional societies, men have sexual relations without concerns about female sexuality. On the contrary, men's erectile dysfunction and premature ejaculation have been regarded as detrimental to sexual relationships since female sexuality has gained similar importance to male sexuality in the context of gender equality. Thus, many men would like to sustain erections for as long as desired and regulate their ejaculation like the experts in the Tantric sex or Taoism. Sexual techniques or teachings of the ancient Tantric sex or Taoism may sound illogical from a modern medical perspective, but they have something to teach us, such as focusing on foreplay to achieve female orgasm. Several issues on men's erectile capability and ejaculation are discussed in this article, while reviewing a variety of viewpoints on male sexual functioning.
| 비뇨기과학 | null | kci_detailed_000252.xml | |||
ART001302712 | oai_dc | 발기부전으로 음경해면체내 Trimix 주사치료법을 장기간 사용하는 환자의 성생활 및 만족도 | Patients’ Satisfaction and Quality of Sex Life in Patients Undergoing Long-term Intracavernous Injections with Trimix | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"정진우(성균관대학교); 이성원(성균관대학교)"
] | Purpose: Intracaverous injections (ICI) are the standard treatment for erectile dysfunction (ED) when oral
phosphodiesterase 5 inhibitors (PDE5I) fail or are contraindicated. However, many patients are wary of
ICI because of aversion to the injection. We assessed patients' satisfaction and the quality of the sex life
in patients undergoing long-term ICI with trimix.
Materials and Methods: One hundred five patients with ED who had used ICI with trimix for at least
6 months were enrolled in the study. We investigated the Erectile Dysfunction Inventory of Treatment
Satisfaction Questionnaire (EDITS), quality of sex life, and pain on injection and erection. The EDITS
questions were scored on a 0 to 4-point scale and the mean scores were multiplied by 25 to normalize the
scores to a 100-point scale and to create the EDITS index. A total score > 50 was defined as “satisfied
with treatment” and a score of < 50 was defined as “not satisfied with treatment.”
Results: The mean age of the patients was 70±8.2 years, the mean duration of ED was 6.4±3.3 years,
and the mean duration of ICI treatment was 50.3±32.6 months. Of the 105 patients, 48.5% had received
PDE5I treatment prior to ICI treatment. Among the 51 patients who had received PDE5I, 72.5% (37/51)
and 19.6% (10/51) discontinued PDE5I due to inefficacy and side effects, respectively. Four patients used
PDE5I in combination with ICI. The mean number of injections was 2.99±1.26 per month and the mean
dose of trimix was 0.33±0.14 ml per injection. The mean EDITS index was 73.7±14.5, and 93% of the patients
were classified in the satisfaction group according to the EDITS index criteria. Patients noted an improvement
in their sex life (78.1%), their relationship with their partner (68.6%), and their quality of life
(65.7%) after using ICI with trimix; 92.3% of patients responded that they were ready to recommend ICI
with trimix to their friends. The mean scores for pain on injection and erection were 1.04/10 and 0.98/10,
respectively. | 비뇨기과학 | null | kci_detailed_000252.xml | |||
ART001302823 | oai_dc | 성장호르몬 결핍증에 의한 발기부전 | A Case of Growth Hormone Deficiency that Induced Erectile Dysfunction | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"최만수(부산의대); 남현종(부산대학교병원 비뇨기과학교실); 강양호(부산대학교); 하홍구(부산대학교); 방성익(부산대학교); 박남철(부산대학교); 김영진(부산대학교병원 비뇨기과학 교실); 박현준(부산대학교)"
] | Growth hormone deficiency is the medical condition of inadequate production of growth hormone. Growth hormone deficiency in adults is not common, but it may feature a diminished, lean body mass, poor bone density and a number of physical and psychological symptoms, including poor memory, social withdrawal and even depression. Abnormally low growth hormone levels in adults typically result in a diminished quality of life and it can even be disabling. The physical symptoms include loss of strength, stamina, and musculature. Growth hormone deficiency can also impair the biological and physiological/functional substrate of penile erection, which can be, at least in part, restored by the normalization of the plasma levels of growth hormone. This is a report on a 63-year-old man who suffered with severe erectile dysfunction and loss of libido due to growth hormone deficiency. Upon growth hormone administration, his erectile function improved dramatically.
| 비뇨기과학 | null | kci_detailed_000252.xml | |||
ART001302849 | oai_dc | 고환과 부고환 사이에 발생한 유선종 | Adenomatoid Tumor between the Epididymis and the Testis | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"지영환(울산대학교); 박성찬(울산대학교); 이승규(울산대학교); 추현수(울산대학교); 김준(울산대학교); 최혜정(울산대학교); 문경현(울산대학교)"
] | Adenomatoid tumor is the most common paratesticular tumor with an anatomic distribution limited to the epididymis and it rarely invades to the tunica vaginalis, spermatic cord and ejaculatory duct. Adenomatoid tumor is a benign neoplasm that is thought to be of a mesothelial origin. The treatment of choice for adenomatoid tumor is local excision because of its benign nature and the absence of distant metastasis. We report here on a rare case of adenomatoid tumor that was found between the epididymis and the testis, and it was treated by local excision of tumor.
| 비뇨기과학 | null | kci_detailed_000252.xml | |||
ART001302778 | oai_dc | 발기부전치료에서 Phosphodiesterase type 5 inhibitor의 작용시작시간 | Onset of Action of Phosphodiesterase Type 5 Inhibitors in the Treatment of Erectile Dysfunction | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"손환철(서울대학교); 김명(서울대학교); 박용현(가톨릭대학교); 정창욱(서울대학교); 김현주(제주대학교); 김영주(제주의대); 허정식(제주대학교)"
] | Purpose: After the market launch of multiple phosphodiesterase type 5 inhibitors (PDE5Is), a considerable amount of information has emerged regarding the efficacy and the time of initiation of these drugs. In clinical situations, however, many patients with erectile dysfunction (ED) have complained about the onset of erection occurring later than expected or desired. We therefore studied the time course for initiating an erection after usage of PDE5Is.
Materials and Methods: One hundred forty-one patients who were medicated with PDE5Is > 4 times in the most recent 3 months were included for study. The patients were divided into 3 groups: sildenafil (n=51), vardenafil (n=51), and tadalafil (n=39). The choice of PDE5I was made according to the patient's and/or doctor's preferences. Regardless of the type of drug selected, the patients were recommended to have sexual stimulation 15 minutes after taking the medication.
Results: The onset of action of the 3 drug groups were significantly different (sildenafil, 57.0±38.5 min; tadalafil, 79.5±50.6 min; and vardenafil, 44.4±26.6 min; p<0.05). Psychogenic causes of ED resulted in a shorter PDE5I onset of action than organic causes of ED. Other factors, such as body mass index and international index of erectile function erectile function domain score, were shown not to differ with respect to the onset of action of PED5Is.
Conclusion: In clinical situations, patients need more time for the onset of erections after taking PDE5Is. For restoration of a healthy sexual life, patients needs more time to achieve an erection after taking PDE5Is.
| 비뇨기과학 | null | kci_detailed_000252.xml | |||
ART001302677 | oai_dc | 실데나필 (비아그라Ⓡ) 장기 복용자 배우자의 성태도와 성관계 및 발기부전치료에 대한 인식 | Sexual Attitude and Perceptions of Sexual Relationships and Erectile Dysfunction Treatment among the Wives of Long-Term Users of Sildenafil (ViagraⓇ) | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"김세철(중앙대학교)"
] | Purpose: This study aimed to investigate the sexual attitudes and perception of sexual relationships and
erectile dysfunction treatment among the wives of the long-term users of sildenafil (ViagraⓇ).
Materials and Methods: The study was conducted as a market survey with using random face-to-face
interviews and a structured questionnaire on a population of 31 wives (mean age; 49.8 years) of long-term
sildenafil users who had first taken sildenafil 5 years or more previously and they continued its use in the
previous 6 months.
Results: All the wives said 'It is desirable to have sex even though I am getting old, if I am healthy'
and 84% had sex not for their satisfaction but for husband's satisfaction. Forty five percent perceived that
having sex 1∼2 times a week was ideal and 35% said having sex once per two weeks was ideal, and
this was not different from happened in their real lives. Ninety four percent and 90% perceived that erectile
dysfunction and women's sexual dysfunction should be treated, respectively, and 35% took a form of
hormonal replacement therapy. The most influencing factors of sildenafil use on the overall satisfaction of
wives' sexual and marital life were the increased frequency and intensity of orgasm and they became more
intimate with their husbands, followed by the disappearance of depressed or annoying moods (p<0.01).
They also felt the improved rigidity of their husband’s erection after initial sildenafil use was maintained
after more than 5-year use.
Conclusions: Wives of long-term sildenafil users had positive, but husband-oriented sexual attitudes.
They had an intercourse-focused perception on their sexual relationship, and they ranked the increased frequency
and intensity of their orgasms and becoming more intimate with husbands as the most influential
factors for their sexual and marital life, and they also felt that their husbands’ erection rigidity was maintained
after more than 5-year use of sildenafil. | 비뇨기과학 | null | kci_detailed_000252.xml | |||
ART001404582 | oai_dc | 한국인에서 전립선 생검의 기준으로 전립선특이항원 절단치 2.5 ng/ml가 적절한가? | Is it Appropriate to Lower the Prostate Specific Antigen Cut-off Value to 2.5 ng/ml for Prostate Biopsy in Korean? | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"윤병일(가톨릭대학교); 조혁진(가톨릭대학교); 홍성후(가톨릭대학교); 손동완(가톨릭대학교); 이지열(가톨릭대학교); 황태곤(가톨릭대학교); 김세웅(가톨릭대학교); 김수진(가톨릭대학교)"
] | Purpose: Currently many clinicians have recommendsprostate biopsy when the level of prostate specific antigen (PSA) is higher than 4.0 ng/ml. However, recently the prostate cancer detection rates werereported to be about 20% at PSA level 2.5 to 4.0 ng/ml. Therefore, an increasing amount of hospitals have recommends lowering the PSA cut off level to 2.5 ng/ml. We retrospectively evaluated the prostate cancer detection rate and pathologic characteristics of patients with PSA level of 2.5 to 4.0 ng/ml and we compared this with the patients who had PSA level in the range of 4.1 to 10.0 ng/ml.
Material and Methods: We analyzed the data of 515 patients who received prostate biopsy in the range of PSA level 2.5 to 10 ng/ml. The clinical characteristics, cancer detection rate and pathologic findings of the biopsy were compared between the PSA 2.5-4.0 ng/ml group and PSA 4.1-10.0 ng/ml group.
Results: Cancer detection rates in patients who underwent biopsy were 18.1% and 22.4% at PSA 2.5 to 4.0 and 4.1 to 10.0 ng/ml, respectively. Mean Gleason scores were found 6.4±0.5 and 6.6±0.7 and high grade cancers with Gleason score 7 or more were found in 50% and 58.4% of patients with cancer with PSA 2.5 to 4.0 and 4.1 to 10.0 ng/ml, respectively. There were no significant difference between the 2 groups in cancer detection rates and pathologic findings on biopsy including mean Gleason score and high grade cancers with Gleason score 7 or more between two groups.
Conclusion: There were no significant difference in cancer detection rates and pathologic findings between PSA 2.5-4 ng/ml group and PSA 4.1-10 ng/ml group. These results suggest that a lower PSA cutoff should be considered as an indication for prostate biopsy in the Korean population. | 비뇨기과학 | null | kci_detailed_000252.xml | |||
ART001404523 | oai_dc | Sexual stimulated (SS)-Penogram을 이용한 발기부전 치료제 Phosphodiesterase 5 억제제들의 임상 효능 분석 | The Analysis of Clinical Efficacy of Phosphodiesterase 5 Inhibitors for Erectile Dysfunction using SS-Penogram | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"최경화(연세대학교); 소병현(나은병원); 오철영(한림대학교); 최형기(연세대학교); 김장환(한림대학교)"
] | Purpose: As the first-line pharmacotherapy for erectile dysfunction (ED), phosphodiesterase type 5 (PDE5) inhibitors are widely used and their clinical efficacy is well established. But up to now, most of these comparative studies have been based on questionnaires, and Udenafil and Mirodenafil, which have recently been developed in South Korea, have not yet to be compared in clinical studies. We compared and analyzed the efficacy of five PDE5 inhibitors using the sexual stimulated (SS)-Penogram.
Materials and Methods: A total of 347 patients taking PDE5 inhibitors for the treatment of ED and underwent SS-Penogram was enrolled in this study. AUC (area under the curve) of SS-Penogram was compared in each PDE5 inhibitors. Differences in AUC according to age, combined disorders, serum testostereone and prolactin, cholesterol and IIEF were also analysed using Chi-square and Kruskal-Wallis test. P-value less than 0.05 was considered as statistically insignificant.
Results: Ratios of Type I curves in medication groups with normal erection were not statistically different before and after medication. Ratios of the excellent response (>50 % increase in area under the curve) and non-response groups (no increase or even decrease in area under the curve) in each medication group were not statistically different.
Conclusions: In this clinical comparative study of the efficacy of PDE5 inhibitors using the SS-Penogram, there were no definite differences in efficacy among PDE5 inhibitors. | 비뇨기과학 | null | kci_detailed_000252.xml | |||
ART001404512 | oai_dc | Premature Ejaculation Diagnostic Tool (PEDT) 한국어판의 개발과 타당도에 대한 연구 | Development and Validation of a Korean Version of the Premature Ejaculation Diagnostic Tool (PEDT) | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"감성철(성균관대학교); 한덕현(삼성서울병원); 허정호(㈜한국얀센); 이성원(성균관대학교)"
] | Propose: Premature ejaculation (PE) is the most prevalent male ejaculation disorder. The premature ejaculation diagnostic tool (PEDT) was developed to systematically apply the DSM-IV-TR criteria in diagnostic PE. This study was designed to assess the validity of the Korean version of the PEDT as a diagnostic tool for PE.
Materials and Methods: The Korean version development of the PDET involved two stages: (1) Development of the initial language version through two independent forward translations and one backward translation. Discrepancies between the original English form and the first draft Korean translation were reviewed by the panel. Discrepancies between the original English form and the Korean translation were reviewed by the panel. (2) For psychometric validation and scoring system development, data was collected from men with and without PE based on clinician diagnosis, using DSM-IV-TR criteria. A total of 98 patients with a DSM-IV-TR defined PE and 100 men without PE were enrolled into the study and requested to complete the PEDT, which was translated into Korean. The PE patients were also requested to measure intravaginal ejaculatory latency time (IELT). The 50 men of no-PE group and all PE group were requested to come for a second visit to assess the PEDT’s retest reliability. The results were analyzed statistically by SPSS version 12.
Result: The mean age of the no-PE group and PE group were 43.4±9.2 and 51.6±9.0, respectively. The geometric mean IELT of the PE group was 115.37±78.14s. The number of men reporting IELTs of <1, 1-<2 and >2min were 28 (28.6%), 29 (29.6%) and 41 (41.8%), respectively. The Cronbach's alpha score of the Korean version of PEDT was calculated as 0.93, showing adequate internal consistency.
The test-retest correlation coefficients of each item were higher than 0.72 and the correlation coefficients of the total score was 0.88. (P<0.001) Sensitivity and specificity analyses suggested a score of ≤8 indicated no-PE, 9 and 10 probable PE, and ≥11 PE. Conclusions: The Korean version of PEDT was highly effective in detecting the presence of PE. The result of our study supports its validity as a diagnostic instrument in the clinical setting. | 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001404589 | oai_dc | 완전 요도 손상을 동반한 음경 골절 | A Penile Fracture with the Complete Urethral Rupture | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"송하정(한림대학교); 이영구(한림대학교); 김기경(한림대학교); 조성태(한림대학교); 송형철(한림대학교)"
] | A penile fracture is an injury caused by the rupture of the tunica albuginea. We report an uncommon case of penile fracture with the complete urethral rupture in a 48-year-old man who sustained the injury during the sexual intercourse. He presented with acute penile pain, swelling on the ventral aspect of the penile shaft and the inability to pass urine associated with urethral bleeding. Retrograde urethrography revealed the complete obstruction of the urethra. Exploration and repair of the penile fracture with the urethra rupture were performed. The patient recovered successfully with good erectile and voiding function. | 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001404633 | oai_dc | 부분 고환 절제술로 치료된 고환 구역성 경색증 | Segmental Testicular Infarction Treated with Partial Orchiectomy | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"조승훈(국립경찰병원); 민승기(국립경찰병원); 이승태(국립경찰병원); 이명진(국립경찰병원); 최재영(국립경찰병원)"
] | Segmental testicular infarction is a rare cause of acute scrotum. Its etiology is not well defined and it can be clinically confused with a testicular tumor. Imaging studies play an important role in the preoperative diagnosis, with a Color doppler ultrasonography as the investigation of choice although magnetic resonance imaging (MRI) can be auseful in doubtful cases. We report a case of segmental testicular infarction treated with partial orchiectomy seen in a 58-year-old man with right scrotal pain. | 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001404570 | oai_dc | 사춘기 정계정맥류환자에서 음낭복합도플러초음파로 측정한 망상정맥총의 역류된 혈류량과 고환용적 차이와의 관계 | The Correlation of Duplex Doppler Ultrasonographic Retrograde Venous Flow Volume and Testicular Volume Difference in Patients with Adolescent Varicocele | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"신홍석(대구가톨릭대학교); 박재신(대구가톨릭대학교)"
] | Purpose: The aim of this study is to assess effects of testicular volume difference and retrograde venous flow of pampiniform plexus measured by Duplex Doppler Ultrasonograpy (DDU) in patients with adolescent varicocele.
Materials and Methods: Physical examinations and DDU were performed to assess varicocele in fifty five patients with left sided adolescent varicocele. During both normal respiration and the Valsalva's maneuver, the maximum venous diameter (MVD), maximal velocity of reflux and the peak retrograde flow volume (RFV) was measured by DDU. The percentage testicular volume difference (%) between the right and left testicle was calculated as (right testicular volume-left testicular volume)x100/right testicular volume and divided into 3 group; below 10%, 10∼20%, >20%. Grade of varicocele, MVD and peak RFV were analyzed as possible determinants of testicular hypotrophy in adolescent varicocele.
Results: A total of 55 patients (mean age 17.8 years, range 12 to 20) were included in this study. Of these, physical examination reviewed that 7 (12.7%), 18 (32.7%), 30 (54.6%) patients had grade I, II or III varicoceles on the left side respectively. The mean MVD was significantly higher according to grade of varicocele. The mean maximal velocity of reflux was significantly higher in the patients grade II and III than grade I, but was not significant between grade II and III. The mean peak RFV was significantly higher according to grade of varicocele. RFV was the only significant parameter of predictive value for percentage testicular volume difference.
Conclusions: Patients with peak RFV >35ml minutes showed significant reduction of testicular volume. Measurement of RFV is recommended as predictive tools for assessing the percentage testicular volume difference in patients with adolescent varicocele. | 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001404414 | oai_dc | 당뇨병성 발기부전 | Diabetic Erectile Dysfunction | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"박관진(서울대학교); 백재승(서울대학교)"
] | Purpose: To understand the pathophysiology of diabetic erectile dysfunction (ED) and to review the current strategies against diabetic ED.
Materials and Methods: A systematic search was performed of MEDLINE databases to obtain articles pertaining to the pathophysiology and management of diabetic ED.
Results: No single etiology has been identified as the principal cause of ED. Studies from non-penile tissue have indicated hyperglycemia-induced mitochondrial superoxide production activates the four damaging pathways by inhibiting glyceraldehyde-3-phosphate dehydrogenase (GAPDH). It appears that these mechanisms provide molecular basis on which diabetes can affect erectile function by increasing reactive oxygen species, forming advanced glycation end products (AGEs) and activating protein kinase C pathway. Consequently, impaired vasorelaxation, enhanced vasoconstriction, nitrergic neural degeneration and structural and functional alteration of cavernosal integrity have been observed in subjects with diabetes. Furthermore, significant hypogonadism often exists in diabetic men, further complicating the understanding of diabetic ED. The treatment of diabetic ED is multimodal. Adequate control of hyperglycemia and comorbidities is prerequisite for the application of various treatments. The type 5 phosphodiesterase inhibitors (PDE5Is) are the mainstay of oral treatment of ED. Vacuum erection device and intracavernosal injection are still viable option when the treatment of PDE5I has failed. Patients with irreversible damage of the erectile mechanism are candidates for penile prosthesis implantation. Current concepts suggest that therapeutic prospects on the horizon include gene therapy, growth factor therapy and novel pharmacotherapies such as anti-AGE drugs.
Conclusions: The current understading of diabetic ED is far from being satisfactory to offer adequate treatment. Future strategies in the evolution of the treatment of diabetic ED are aimed at correcting or treating underlying mechanisms. | 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001404502 | oai_dc | 토끼의 정낭 평활근에 존재하는 칼륨통로의 성상에 대한 연구 | The Study of K Channels in Smooth Muscle Cells of Rabbit Seminal Vesicle | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"양규상(중앙대학교); 한상훈(중앙대학교); 이무열(중앙대학교); 이종성(중앙대학교)"
] | Purpose: Ionic currents in smooth muscle have fundamental roles in initiation and maintenance of excitability and contractile status. So we studied and characterized potassium ion channels in smooth muscle cells of rabbit seminal vesicle.
Materials and Methods: Single smooth muscle cells of New Zealand White rabbit seminal vesicle were obtained using proteolytic enzymes (collagenase and papain). Using single cell and channel recording methods of patch clamp, potassium channels in smooth muscle of seminal vesicle were recorded.
Results: Potassium currents recorded whole-cell patch clamp method were divided into maxi-K channel dominant cells (n=11) and the cells with mixture of maxi-K and delayed rectifier K channels (n=7). Inside-out mode of patch clamp technique was used to characterize the maxi-K channel. The channel showed outward rectification and Ca-dependency. The single channel conductance of this channel estimated from slope conductance was 188 pS in physiological condition. These characters were typical properties of maxi-K channel.
Conclusions: From these results it is suggested that maxi-K channel was predominantly distributed in rabbit seminal vesicle cell. The physiological roles of this channel in modulating seminal vesicle smooth muscle tone need further studies. | 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001404463 | oai_dc | 조루증의 새로운 접근과 치료법 | New Approach and Treatment of Premature Ejaculation | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"감성철(성균관대학교); 이성원(성균관대학교)"
] | Premature ejaculation (PE) is the most common form of male sexual dysfunction. Until very recently, scientific investigation of PE has been hampered by a lack of standardized definitions and objective, validated questionnaires. In recent years both the definition and the management of PE have changed from the traditional authority-based to a more evidence-based approach. In 2007, the International Society for Sexual Medicine (ISSM) established an ad hoc committee consisting of 21 internationally recognized experts, to establish a new definition of PE including intravaginal ejaculation latency time (IELT). As diagnostic tools, a brief self-administered questionnaire, the premature ejaculation diagnostic tool (PEDT), was developed and validated. Current accepted treatment options of PE include behavior therapy, topical desensitizing agents, selective serotonin reuptake inhibitors (SSRIs), clomipramine, tramadol, PDE-5 inhibitors. However, it should be noted that all of the medications currently used for treatment of PE were originally developed to treat other medical disorders such as depression or erectile dysfunction. Dapoxetine, a new SSRI, has a unique pharmacokinetic profile, with a short time to maximum serum concentration, and rapid elimination. By 24 hours, plasma concentrations are less than 5% of peak values. These attributes make Dapoxetine suitable for on-demand therapy of PE. This paper reviewed new diagnostic tools and treatment options for PE. | 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001404492 | oai_dc | 토끼의 음경해면체 평활근에 ethanol 및 acetaldehyde가 미치는 영향 | The Effects of Ethanol and Acetaldehyde on Corpus Cavernosal Smooth Muscle of the Rabbit | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"이경래(타워 비뇨기과); 배재현(고려대학교); 김진욱(); 심강수(안동병원); 오미미(고려대학교); 박민구(고려대학교); 문두건(고려대학교); 김제종(고려대학교)"
] | Purpose: This study is to assess the pharmacologic effects of ethanol and its metabolite, acetaldehyde on potassium channels of the corpus cavernosal smooth muscle of the rabbit.
Materials and Methods: Cavernosal strips from New Zealand white rabbits were harvested and pharmacophysiologic organ bath studies were executed. In equilibrium state after incubation, zaprinast (PDE5 inhibitor) induced relaxations were monitored in strips precontracted with phenylephrine (PE, 10-4M). The inhibitory effects of ethanol and acetaldehyde (2, 20, 40, 80 mmol) on zaprinast-induced relaxations were recorded. Pinacidil (KATP channel opener) and phloretin (BK channel opener) were tested to reverse the inhibitory effects of ethanol and acetaldehyde on zaprinast-induced relaxations.
Results: Both ethanol and acetaldehyde inhibited the zaprinast-induced relaxations in a dosedependent manner (p<0.05). Both pinacidil and phloretin abolished the inhibition by both ethanol and acetaldehyde (p<0.05). Ethanol and acetaldehyde inhibits cavernosal relaxation, possibly through BK channels and KATP channels.
Conclusions: These results suggest that ethanol and its metabolite may affect the corpus cavernosal smooth muscle directly and lead to consequent erectile dysfunction. Furthermolecular and electrophysiological studies will help reveal the underlying mechanisms to which this process occurs. | 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001404529 | oai_dc | 통증을 동반한 정계정맥류 환자에서 정계정맥류 결찰술 비교: 후복막 접근 고환동맥 보존법, 복강경 접근, 서혜부하 접근 미세수술 | A Comparative Study of Varicocelectomy for Painful Varicocele: Modified Palomo, Laparoscopic Approach and Microscopic Subinguinal Approach | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"여정균(인제대학교)"
] | Purpose: To compare pre-and postoperative scrotal pain in patients with varicocele who underwent varicocelectomy with different approaches and to identify the factors that affect the outcomes.
Materials and Methods: A total of 48 patients with left-sided varicocele who had left scrotal pain was included and followed up for more than 3 months. Twenty patients underwent varicocele ligation using modified Palomo, fifteen with laparoscopic approach and thirteen with microscopic subinguinal varicocelectomy respectively. Visual pain scale was used at pre-operation and 3 months later postoperatively. We compared age, grade, a character of pain, operation time, a number of pain killer and pain score.
Results: Mean age of patients was 28.9 years (range 15∼58 years). 45 patients described their pain as dull ache and 3 as a sharp sensation. There was complete resolution of pain in 35 patients (72.9%), while 7 (14.5%) had partial resolution. 6 (12.5%) had persistent symptoms and varicocele recurred in 3 (6.2%). There was no significant difference in pain resolution according to surgical approaches. Microsurgical approach had a prolonged operation time, but recurrence was not occurred. 3 patients that had a sharp scrotal pain were included in partial resolution or persistent pain.
Conclusions: Surgical approaches were effective in the treatment of painful varicocele in selected patients and there was no significant difference in pain resolution according to surgical approaches. The sharp scrotal pain was related to the outcome of treatment. | 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001404647 | oai_dc | 음경에 생긴 감염된 표피낭: 포경수술 합병증 | An Infected Epidermal Cyst of Penis: A Complication of Circumcision | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"여정균(인제대학교)"
] | A 21-year old male complained pain in his penis which has rapidly grown in its mass. We found a cystic mobile mass of about 2cm in diameter at the frenulum of the penis. A modified circumcision was performed ten years ago that an incised skin of prepuce was rolled and implanted in the operation site. The patient found an asymptomatic small nodule one month after a circumcision. We found no communication with the urethra. We performed an excision of the mass to confirm the diagnosis. Pathologic examination revealed epidermal cyst and abscess formation. We used antibiotics for treatment of infection. | 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001373788 | oai_dc | 음경재활 | Penile Rehabilitation | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"양대열(한림대학교)"
] | Erectile dysfunction following radical prostatectomy is significant quality of life issue even with increased understanding of the anatomy and advancement of surgical skills such as nerve sparing prostatectomy, laproscopic, and robotic surgery. The changes of neuropraxia, ischemic and hypoxic injury vascular damage, fibrotic remodeling, and venous leak are all believed to contribute to erectile dysfunction. Penile rehabilitation is the use of any drug or device at or after radical prostatectomy to preserving penile function and earlier return of potency. There are no generally accepted guidelines for penile rehabilitation regiments. There exist several popular options such as PDE5I (phosphodiesterase type 5 inhibitor), intracorporeal injection of vasoactive agent, vacuum device, intraurethral alprostadil, and combination of these modalities. Current animal and human data support the primary use of PDE5I (phosphodiesterase type 5 inhibitor) for nerve sparing and injection of vasoactive agent for supposed nerve injury patients. Some experimental modalities including hyperbaric oxygen therapy, neuromodulator, and stem cell strategies are under preclinical study. This paper will review the literatures involving both basic and clincial evidences for rehabilitation approaches following radical prostatectomy. | 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001373802 | oai_dc | Fibrin으로 유도된 페이로니병 동물모델에서 transforming growth factor-β 제1형 수용체억제제인 IN-1130의 효과 | Effect of IN-1130, a Novel Transforming Growth Factor-β Type I Receptor Kinase (ALK5) Inhibitor, on a Rat Model of Peyronie’s Disease Induced by Repeated Intratunical Injections of Fibrin | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"박서광(인하대학교); 박수환(인하대학교); 서준규(인하대학교); 류지간(인하대학교); 뭉크하야르(인하대학교); 오준형(인하대학교)"
] | Purpose: Transforming growth factor-β1 (TGF-β1) has been known to be involved in the pathogenesis of Peyronie’s disease (PD). In the present study, we investigated the therapeutic effect of IN-1130, a novel small molecule inhibitor of activin receptor-like kinase (ALK)5, a type I receptor of TGF-β, in an animal model of PD induced by fibrin.
Materials and Methods: Four-month-old male Sprague-Dawley rats were divided into three groups (n=4 per group): group 1, age-matched control; group 2, PD rats without treatment; group 3, PD rats receiving an intratunical injection of IN-1130 (on day 20, 5 mg/kg in 0.1 ml saline) into the lesion. PD was induced in rats through repeated injections of fibrin (50 μl each of human fibrin and thrombin solutions, days 0, 3, and 6, respectively) into the tunica albuginea. Penile curvature was evaluated by use of an artificial erection test on day 30. The penis was then harvested and stained with Masson trichrome, hematoxylin-eosin, and antibody to vimentin and phospho-Smad2.
Results: PD rats receiving repeated intratunical injections of fibrin revealed an infiltration of inflammatory cells, including lymphocytes, plasma cells, and fibroblasts, and an increase in transnuclear expression of phospho-Smad2 in the fibrotic plaque. However, repeated intratunical injections of fibrin did not induce penile curvature. IN-1130 induced significant regression of fibrotic plaque through reduced infiltration of inflammatory cells and reduced transnuclear expression of phospho-Smad2.
Conclusions: Inhibition of TGF-β pathway through the use of ALK5 inhibitors may be a curative local treatment modality for PD.
| 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001373836 | oai_dc | 심혈관질환 위험인자가 하부요로증상과 발기부전에 미치는 영향 | The Adverse Effects of Cardiovascular Risk Factors on Lower Urinary Tract Symptoms and Erectile Function | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"김선옥(전남대학교); 손경철(전남대학교); 박광성(전남대학교); 권동득(전남대학교); 류수방(전남대학교); 김준석(전남대학교); 김희선(전남대학교); 임창민(전남대학교)"
] | Purpose: There are several reports about relationships between cardiovascular risk factors and lower urinary tract symptoms (LUTS). We investigated the effects of risk factors for vascular disease on LUTS and erectile function (ED).
Materials and Methods: We prospectively analyzed 273 patients who had LUTS or ED. A self administered questionnaire of International Prostate Symptom Score (IPSS) and International Index of Erectile Function (IIEF) were given to patients. Cardiovascular risk factors including hypertension, smoking status, diabetes and dyslipidemia were determined in each patients.
Results: Mean age was 60.5±9.4 years. Mean IPSS, IIEF and IIEF-EF score were 15.9±5.9, 30.1±15.4 and 17.35±9.0, respectively. There are statistically significant differences in the IPSS (p=0.047), IIEF (p=0.024) and IIEF-EF domain score (p=0.044) between men with no risk factors and men with one or more risk factors. IPSS, IIEF and IIEF-EF score were 11.5±6.4, 39.8±11.9 and 19.6±8.7 in men with no risk factor (n=94), 16.6±5.6, 28.4±15.0 and 15.1±9.3 in men with at least one risk factor (n=179). In men with one to four risk factors, the mean IPSS was 14.5±5.1 (n=63), 16.3±4.4 (n=45), 21.2±5.5 (n=43) and 26.5±3.5 (n=28)(p=0.001); the mean IIEF score was 31.4±14.2, 27.8±16.8, 22.5±14.1 and 19.0±9.9 (p=0.037); the mean IIEF-EF score was 17.1±8.9, 14.7±9.0, 10.9±9.7 and 8.8±4.5 (p=0.023), respectively.
Conclusions: Men with risk factors for vascular disease are more likely to have a higher IPSS and a lower IIEF and IIEF-EF score than men without risk factors. These results suggests that vascular disease of men is significantly related with the progression of LUTS and ED. | 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001373891 | oai_dc | 음경 귀두의 정중봉선 낭종 | Median Raphe Cyst on Glans Penis | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"강용진(인하대학교); 김루시아(인하대학교); 박수환(인하대학교); 류지간(인하대학교); 신태영(인하대학교); 오준형(인하대학교); 정해도(인하대학교)"
] | Median raphe cyst is a relatively uncommon disease and is caused by a defect in the embryonic development of male genitalia. Here, we report a case of median raphe cyst on the glans penis in a 20-year-old male, which was successfully treated by surgical excision.
| 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001373787 | oai_dc | 남성갱년기증후군의 검사, 치료 및 추적관찰을 위한 2008 ISA, ISSAM, EAU, EAA 및 ASA 권고안 해설 | A Manual of 2008 ISA, ISSAM, EAU, EAA and ASA Recommendations: Investigation, Treatment and Monitoring of Late-onset Hypogonadism in Males | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"박남철(부산대학교)"
] | The 2008 new recommendations from professional societies including ISA, ISSAM, EAU, EAA and ASA on the investigation, treatment and monitoring of late-onset hypogonadism in males provide updated evidence-based informations for clinicians who diagnose and treat patients with adult-onset, age-associated testosterone deficiency.
| 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001373888 | oai_dc | 고환 손상 환자에서 우연히 발견된 다고환증 | Incidental Polyorchidism in Testicular Injury | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"박형철(분당제생병원); 김은석(분당제생병원); 정은홍(분당제생병원); 문근배(분당제생병원); 김재일(분당제생병원)"
] | Polyorchidism is a very rare congenital anomaly and about 100 cases have been documented in the literature until today. Polyorchidism or supernumenary testis is defined as the presence of more than 2 histologically proven testes. In most case, polyorchidism have characteristics of unilateral involvement and three testis and mainly finding in left-side testis. And although patient age was various, average age was about 18-year-old in previous review of article. We report a rare case of polyorchidism that an old age patient had an incidentally found right accessory testis in operating a testicular injury.
| 비뇨기과학 | null | kci_detailed_000253.xml | |||
ART001373871 | oai_dc | 의료인과 비의료인의 발기부전 치료제 비아그라의 인식에 대한 실태조사 | A Survey of Understanding of Viagra in primary Physician and General Population | {
"journal_name": "대한남성과학회",
"publisher": null,
"pub_year": null,
"pub_month": null,
"volume": null,
"issue": null
} | [
"서원익(인제대학교); 강필문(인제대학교); 민권식(인제대학교); 김학민(인제대학교); 엄재두(인제대학교); 전지연(인제대학교)"
] | Purpose: Sildenafil citrate(ViagraⓇ), a PDE-5 inhibitor in the corpus carvenosum to facilitate penile erection has improved impaired erectile responses in men and has been accepted as a primary treatment of erectile dysfunction. However, complications occurred by Viagra have increased due to its overuse and misuse. Therefore, we have performed a survey to compare physicians and general population in Busan, Korea to assess their understanding of Viagra.
Methods and Materials: In 2007, printed surveys were mailed to randomly sampled candidates of 197 primary physicians and 696 individuals from general population, 327 medical students in Busan were surveyed by door-to-door visits. We assessed opinions associated with Viagra eliciting their understanding about its safety, direction, and complications. Data were analyzed using SPSS and were identified by crosstabulation analysis using Ki-square test.
Results: Of 1,265 eligible responses, several differences were found between the 3 groups. Compared to general population, the others were more likely to understand the efficacy, directions, and complications of Viagra. Physicians and medical students(43.1% and 39.0%) gave more preference than general population(26.1%) to using Viagra. There were differences in understanding of Viagra with changes of education level. However, it showed no significant differences about idea of illegal Viagra and combination usage with nitrates.
Conclusion: The number of patients using Viagra is increasing but their understanding about Viagra is still poor. Moreover, general populations understand Viagra as 'assistant' for erection poorly. Even some medical students understand more than physicians. The ideas of complications would likely affect to negative thinking about usage for Viagra. Therefore more active and continuous educations for proper use of Viagra are suggested for medical efficacy and less complications.
| 비뇨기과학 | null | kci_detailed_000253.xml |
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