title stringlengths 1 1.19k | keywords stringlengths 0 668 | concept stringlengths 0 909 | paragraph stringlengths 0 61.8k | PMID stringlengths 10 11 |
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4.3. Prediction Model | Currently, the usual management for overweight and obesity is done by calculating energy expenditure, establishing daily nutritional requirements, and performing caloric restriction, in addition to giving recommendations for lifestyle changes specific to each individual [ | PMC10746100 | ||
4.4. BMI Percentage Loss Prediction Model Based on the MHP and LF Diets’ Methylation Data | BMI loss, weight loss | The model that predicts the percentage of BMI loss was made with a total methylation score that was constructed considering the MHP diet methylation score, in which the 15 CpG sites that were better associated with the reduction of BMI percentage were selected and 11 CpG sites for the LF diet. With this model, it was p... | PMC10746100 | |
4.5. Strengths and Limitations | obesity | OBESITY | One of the main strengths of this pilot research is that it was carried out within the framework of a randomized clinical study in which more than 200 people were characterized. A methylation array was used to analyze around 850,000 methylation sites in each individual at baseline. Multiple methylation sites were ident... | PMC10746100 |
5. Conclusions | weight loss | This pioneer research demonstrates that DNA methylation is an individual characteristic that can be used to have greater precision in the nutritional treatment of BMI reduction. The model designed based on the methylation information through the linear mixed effect model allows predicting the percentage of BMI loss and... | PMC10746100 | |
Supplementary Materials | The following supporting information can be downloaded at Click here for additional data file. | PMC10746100 | ||
Author Contributions | Conceptualization, F.I.M. and J.A.M.; methodology, F.I.M. and J.I.R.-B.; formal analysis, J.I.R.-B. and S.G.-C.; investigation, N.C.G.-Á. and S.G.-C.; resources, F.I.M. and J.A.M.; data curation, J.I.R.-B.; writing—original draft preparation, N.C.G.-Á.; writing—review and editing, F.I.M., J.I.R.-B., J.A.M. and S.G.-C.;... | PMC10746100 | ||
Institutional Review Board Statement | The study was performed in line with the guidelines of the Declaration of Helsinki and received approval by the Ethics Committee of the University of Navarra (ref. 132/2015). | PMC10746100 | ||
Informed Consent Statement | Informed consent was obtained from all subjects involved in the study. Written informed consent has been obtained from the patients to publish this paper. | PMC10746100 | ||
Data Availability Statement | Data will be available upon request by contacting the corresponding author. | PMC10746100 | ||
Conflicts of Interest | The authors declare that they have no conflict of interest. | PMC10746100 | ||
References | TNF-α, tumor necrosis | REGRESSION, INSULIN RESISTANCE, TUMOR NECROSIS | Flow chart of the participants who started and completed the intervention.Flow chart for the design of the prediction model based on DNA methylation.Flow chart for the selection of methylation sites (CpG) used for the prediction model.Prediction model of the percentage of BMI loss according to the total methylation sco... | PMC10746100 |
Background | obesity, NAFLD, appetite | OBESITY, NONALCOHOLIC FATTY LIVER DISEASE | Academic Editor: Cornelia Amălinei This trial assessed the effects of a calorie-restricted diet (CRD) with hydroxycitric acid (HCA) supplementation on appetite-regulating hormones, obesity indices, body composition, and appetite in women with nonalcoholic fatty liver disease (NAFLD). | PMC10356186 |
Methods | NAFLD | This study was carried out on 44 overweight/obese women with NAFLD. The patients were randomly assigned into two groups, namely, “ | PMC10356186 | |
Results | obesity | OBESITY | Forty patients completed the trial. At the end of the trial, although significant reductions were found in most of the studied obesity indices in the intervention group, there was only a significant decrease in waist circumference and waist-to-height ratio in the control group. Fat mass and muscle mass significantly d... | PMC10356186 |
Conclusion | weight loss diet | HCA plus weight loss diet could significantly reduce visceral adipose tissue without any significant changes in serum leptin and adiponectin levels. | PMC10356186 | |
1. Introduction | NAFLD | NONALCOHOLIC FATTY LIVER DISEASE, CHRONIC LIVER DISEASE | Nonalcoholic fatty liver disease (NAFLD) is recognized as the most frequent chronic liver disease globally [
| PMC10356186 |
2. Methods | PMC10356186 | |||
2.1. Study Design and Participants | LIVER DISEASES, COMPLICATIONS | In this single-blind, controlled, and randomized clinical trial, 142 female patients aged between 18 and 50 years and BMI = 27.5–40 kg/mThis paper is a part of already published studies [Those who were pregnant or lactating, had menopause, were alcohol drinker, or smoker, followed a weight-loss diet, and took dietary s... | PMC10356186 | |
2.2. Sample Size | The sample size was determined based on the mean and standard deviation (SD) of serum leptin level at baseline reported by Vasques et al. [ | PMC10356186 | ||
2.3. Randomization, Blinding, and Intervention | weight loss | The patients were randomly assigned to one of the two study groups (1 : 1). The randomized block procedure of size 4 was applied, and the sequence was generated using the random allocation software (RAS). Randomization was stratified by age (18–35 yrs. To assess habitual diet for each subject, a validated 169-item food... | PMC10356186 | |
2.4. Measures and Assessments | To assess dietary intakes, the subjects completed three food records (two nonconsecutive weekdays and a weekend) and data on food intake were analyzed by Nutritionist IV software (First Databank, USA) modified for Iranian foods. Appetite status was assessed using a validated 6-item questionnaire based on 100 mm visual ... | PMC10356186 | ||
2.5. Statistical Analysis | Data analysis was conducted using SPSS 25.0 software (SPSS Inc., Chicago, IL, USA). The Kolmogorov–Smirnov test was used for checking the normality of the data distribution. Between-group comparisons at baseline were tested using the independent samples | PMC10356186 | ||
3. Results | Forty patients completed the trial.
Appetite status assessed by VAS is presented in
Changes in serum levels of leptin and adiponectin over the trial are presented in
| PMC10356186 | ||
4. Discussion | obesity | OBESITY | Results of this trial showed significant reductions in obesity indices and total and visceral fat without any significant change in serum leptin and adiponectin levels. Although energy and macronutrient intakes decreased in both groups, greater reductions were observed in the control group than in the intervention grou... | PMC10356186 |
5. Conclusion | NAFLD, LCD | OBESE | It is concluded that HCA plus LCD in obese women with NAFLD could significantly reduce visceral adipose tissue without any significant changes in serum leptin and adiponectin levels. | PMC10356186 |
Acknowledgments | The authors sincerely thank the patients who participated in this clinical trial. The authors would like to appreciate the cooperation of the Clinical Research Development Unit of Imam Reza General Hospital, Tabriz, Iran, in conducting this research. This study was written based on the data obtained from the M.Sc. Thes... | PMC10356186 | ||
Data Availability | The datasets used and analyzed during the current study are not publicly available due to our center's patient confidentiality policies, but they are available from the corresponding author on reasonable request. | PMC10356186 | ||
Conflicts of Interest | The authors declare that they have no conflicts of interest. | PMC10356186 | ||
Authors' Contributions | NAFLD, Obesity, obesity, skeletal muscle mass, FM, HT | OBESITY, NONALCOHOLIC FATTY LIVER DISEASE, OBESITY | The authors' responsibilities were as follows: MEM contributed to the conception of the article; SA, SNG, and HT wrote the original paper; MEM contributed to the statistical analysis; and MEM and HT contributed to the final revision of the manuscript. All authors read and approved the final version of the manuscript.Fl... | PMC10356186 |
1. Introduction | obese, endotoxemia, cancer, weight reduction, metabolic diseases, overweight, post-prandial endotoxemia | METABOLIC DISEASES, CANCER, OBESE, ENDOTOXEMIA | Sugar-rich diets, but also the use of intense sweeteners, may alter intestinal barrier function. Here, we assessed the effect of sucrose and sucralose on post-prandial endotoxemia in a randomized placebo-controlled single-blinded crossover-designed study. Following a 2-day standardization of their diet, healthy men and... | PMC10537596 |
2. Materials and Methods | PMC10537596 | |||
2.1. Study Participants | post-prandial endotoxemia | This randomized controlled prospective human intervention study in crossover design was approved by the Ethics Committee of the University of Vienna (reference number: 00585) and was carried out in accordance with the ethical standards laid down in the Declaration of Helsinki. Originally, it was planned to investigate ... | PMC10537596 | |
2.2. Intervention Study | The study design is summarized in | PMC10537596 | ||
2.3. Anthropometry, Blood Pressure and Metabolic Parameters | BLOOD | At the beginning and over the course of the study, anthropometric data and blood pressure were determined. Blood lipids were measured using a commercially available measuring instrument (Swiss Point of Care, LJ IJsselstein, The Netherlands). Blood sugar levels were assessed in capillary blood obtained from the fingerti... | PMC10537596 | |
2.4. Bacterial Endotoxin | To assess the effect of the standardized nutrition as well as of the different beverages on bacterial endotoxin levels in plasma of participants over time, a limulus amebocyte lysate assay was used (Charles River, Ecully, France) as detailed previously [ | PMC10537596 | ||
2.5. Caco-2 Cells In Vitro Experiments | Differentiated Caco-2 cells (ACC 169, DSMZ, Braunschweig, Germany) were grown in trans-wells by using DMEM medium containing 10% fetal bovine serum (Pan-Biotech GmbH, Aidenbach, Germany) and 100 µg/mL streptomycin and 100 U/mL penicillin (Pan-Biotech GmbH, Aidenbach, Germany) in a 5% carbon dioxide atmosphere. After re... | PMC10537596 | ||
2.6. Enzyme-Linked Immunosorbent Assay (ELISA) | Intestinal fatty acid | Intestinal fatty acid binding protein (iFABP) concentrations were analyzed in cell culture supernatant of the apical side of the Caco-2 cell trans-well model using a commercially available ELISA kit (Bio-Techne Corp., Minneapolis, MN, USA). | PMC10537596 | |
2.7. Ex Vivo Everted Gut Sac Experiments and Xylose Permeation Measurement | SMALL INTESTINE | Small intestine ( | PMC10537596 | |
2.8. Statistical Analysis | Data are presented as means ± SEM. To test for normality, a Shapiro–Wilk normality test was performed. Grubb’s test was used before statistical analysis to identify outliers. To assess the effects between two paired groups, a paired | PMC10537596 | ||
3. Results | PMC10537596 | |||
3.1. Baseline Characteristics and Nutritional Standardization | corona infections | Of the 18 normal-weight, healthy men and women enrolled in the study, 11 participants finished the study and were analyzed. Seven participants did not start the study as they dropped out of the study due to corona infections ( | PMC10537596 | |
3.2. Effect of an Acute Intake of Sucralose, Sucrose and an Isocaloric Combination of Sucralose and Maltodextrin, Respectively, on Post-Prandial Bacterial Endotoxin Levels in Blood | After the intake of the sucrose-sweetened beverage, plasma endotoxin levels increased significantly when compared with baseline levels (120 min: +~45%, 180 min: +~36% compared with baseline, | PMC10537596 | ||
3.3. Effect of Sucralose and Sucrose on Bacterial Endotoxin Permeation and Protein Levels of iFABP in Differentiated Caco-2 Cells | To further assess if the increase in bacterial endotoxin levels found after the intake of sucrose was related to changes in intestinal barrier function and to compare these effects with those of sucralose, a model of the intestinal barrier, e.g., differentiated Caco-2 cells grown on trans-well inserts was employed in w... | PMC10537596 | ||
3.4. Effect of Sucralose and Sucrose on Markers of Intestinal Barrier Function in Small Intestinal Everted Tissue Sacs of C57BL/6J Mice | When challenging small intestinal everted tissue sacs with sucrose, the permeation of xylose significantly increased compared with tissue sacs only incubated with 1× Krebs–Henseleit buffer. In contrast, the intestinal permeation of xylose was not altered when tissue sacs were challenged with sucralose ( | PMC10537596 | ||
4. Discussion | weight gain | DISEASES | Intense sweeteners widely used in human nutrition as substitutes for sugars like sucrose or high-fructose corn syrup may have beneficial effects with regard to body weight gain and the development of some non-communicable diseases [In line with our previous findings [ | PMC10537596 |
Limitations | MASLD, metabolic abnormalities | TYPE 2 DIABETES | Our study is not without limitations that need to be considered when interpreting the data. A major limitation of our study is the sample size of only 11 subjects and the focus on young, healthy adults. The results might differ in a larger cohort and in another age group as well as in subjects with metabolic abnormalit... | PMC10537596 |
5. Conclusions | intestinal barrier dysfunction | METABOLIC DISEASES, INTESTINAL BARRIER DYSFUNCTION, TYPE 2 DIABETES | In summary, our data suggest that the intake of a sucralose-sweetened beverage in a physiological amount, e.g., 1 L, has no effect on intestinal barrier function in healthy young adults. To our knowledge, this is the first study which examines the effect of an acute intake of sucralose on endotoxin levels in healthy, n... | PMC10537596 |
Author Contributions | Conceptualization, I.B.; Formal analysis, R.S.; Funding acquisition, I.B. and A.B.; Investigation, R.S., V.S. and A.B.; Visualization, R.S. and A.B.; Writing—original draft, R.S., I.B. and A.B., Writing—review & editing, R.S., V.S., I.B. and A.B. All authors have read and agreed to the published version of the manuscri... | PMC10537596 | ||
Institutional Review Board Statement | The study was conducted in accordance with the Declaration of Helsinki and approved by the Ethics Committee of the University of Vienna (protocol code 00585, 13 January 2021). | PMC10537596 | ||
Informed Consent Statement | Informed consent was obtained from all subjects involved in the study. | PMC10537596 | ||
Data Availability Statement | Data are made available upon reasonable request. | PMC10537596 | ||
Conflicts of Interest | The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analysis or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. | PMC10537596 | ||
References | Design of the randomized controlled single-blinded crossover-designed human intervention study.Effect of a beverage containing either sucrose, sucralose or sucralose + maltodextrin on bacterial endotoxin levels in peripheral blood 60, 120 and 180 min after the consumption of the respective beverage. Values are means ± ... | PMC10537596 | ||
Purpose | fracture, weight loss, bone loss | BONE LOSS | Intentional weight loss has been shown to increase bone loss short term but the long-term effects are not known. Data from the Look AHEAD clinical trial shows that a long term intentional weight loss intervention was associated with greater bone loss at the hip in men.Intentional weight loss has been shown to increase ... | PMC10348976 |
Methods | weight loss, bone loss | BONE LOSS | Data from a subgroup from the Look AHEAD (LA) multicenter, randomized clinical trial was used to evaluate whether a long term intentional weight loss intervention would increase bone loss. In a preplanned substudy, BMD was assessed at 5 of the 16 LA clinical centers using dual-energy X-ray absorptiometry at baseline, y... | PMC10348976 |
Results | At year 8, bone density loss (%) was greater in the Intensive Lifestyle Intervention (ILI) group compared with the control group (DSE) for the femoral neck ( | PMC10348976 | ||
Conclusion | fracture, weight loss | BONE LOSS | Long term intentional weight loss was associated with greater bone loss at the hip in men. These results taken with the previously published Look AHEAD data from the entire clinical trial showing increased frailty fracture risk with weight loss in the ILI group suggest that when intentional weight loss is planned, cons... | PMC10348976 |
Trial Registration | Clinicaltrials.gov Identifier: NCT00017953. June 21, 2001 | PMC10348976 | ||
Supplementary Information | The online version contains supplementary material available at 10.1007/s11657-023-01303-0. | PMC10348976 | ||
Keywords | PMC10348976 | |||
Introduction | overweight / obesity, DM, weight loss, diabetes | DIABETES | Among the US population, it is estimated that over 34 million people have diabetes and this risk increases with age and increasing body mass index (BMI) [Therefore, the purpose of this analysis is to examine whether this long term intentional weight loss intervention resulted in sustained bone density loss, beyond four... | PMC10348976 |
Methods | DM, Fracture, fracture | The Look AHEAD randomized clinical trial involved 16 clinical sites across the US (Clinicaltrials.gov Identifier: NCT00017953). The methods and baseline characteristics of the study population have been published and the protocol is available (Intervention curricula for both ILI and DSE were developed centrally and hav... | PMC10348976 | |
Dual-energy X-ray absorptiometry (DXA) substudy | SECONDARY | Look AHEAD was also designed to examine secondary outcomes including areal BMD changes. In a preplanned substudy, total hip, lumbar spine, and whole body DXA scans were obtained at baseline, year 1, year 4, year 8, and at the observational visit which occurred 12.6 – 16.3 years after randomization (year 12–16) at five ... | PMC10348976 | |
Fracture ascertainment | fracture, fractures, primary fracture | EVENTS, SECONDARY | During annual visits and telephone calls every 6 months, staff members who were unaware of study-group assignments (blinded) queried participants about all medical events and hospitalizations including incident fractures. Hospital and other records such as outpatient medical records and x-ray reports were reviewed for ... | PMC10348976 |
Statistical analysis | bone loss | BONE LOSS | Baseline characteristics were summarized with means and standard deviations for continuous variables, and frequencies and percents for categorical variables, stratified by randomization arm and gender. Comparisons between randomization arms were made with t-tests or chi-square tests of association as appropriate with a... | PMC10348976 |
Discussion | obesity, fracture, weight loss, bone loss | OSTEOPOROTIC FRACTURES, OBESITY, SECONDARY, BONE LOSS | In the Look AHEAD clinical trial in persons with overweight and obesity and with DM, we previously found that an intensive lifestyle intervention that resulted in intentional long term weight loss and improved fitness increased the risk of frailty fracture [Our finding of increased bone loss with weight loss is consist... | PMC10348976 |
Conclusion | fracture, weight loss | BONE LOSS | Long term intentional weight loss was associated with greater bone loss at the hip in men long term and in women in the shorter term. These results taken with the previously published Look AHEAD fracture data from the entire clinical trial showing increased frailty fracture risk in the ILI group with intentional weight... | PMC10348976 |
Funding | Bartter, Johnson & Johnson Company, Digestive, Diabetes | LUNG, KIDNEY DISEASES, DIABETES, BLOOD, HEART, DISEASE | Funded by the National Institutes of Health through cooperative agreements with the National Institute on Aging: AG058571 and National Institute of Diabetes and Digestive and Kidney Diseases: DK57136, DK57149, DK56990, DK57177, DK57171, DK57151, DK57182, DK57131, DK57002, DK57078, DK57154, DK57178, DK57219, DK57008, DK... | PMC10348976 |
Data Availability | Digestive, Diabetes | KIDNEY DISEASES, DIABETES | Data that support the findings from the Look AHEAD trial (Action for Health in Diabetes) can be accessed through application to the National Institute of Diabetes and Digestive and Kidney Diseases; NIDDK Central Repository: | PMC10348976 |
Declarations | PMC10348976 | |||
Ethical approval | All procedures performed in the Look AHEAD study involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. | PMC10348976 | ||
Informed consent | Informed consent was obtained from all individual participants included in the study. | PMC10348976 | ||
Competing interests | Andrea Anderson | SCHWARTZ | The authors have disclosed the following financial and non-financial competing interests and funding.Karen C. Johnson, MD, MPH – The author declares that they have no conflict of interest.Andrea Anderson, MS—The author declares that they have no conflict of interest.Kristen M. Beavers, PhD—The author declares that they... | PMC10348976 |
Human and animal rights | The Look AHEAD study was approved by the appropriate institutional research ethics committees and was performed in accordance with the ethical standards as laid down in the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards. | PMC10348976 | ||
References | PMC10348976 | |||
Background | cancer, Inflammation | CANCER, DISEASE, MALIGNANCIES, INFLAMMATION | Edited by: Luisa Giaccone, University of Turin, ItalyReviewed by: Elisabetta Metafuni, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Italy; Sakhila Ghimire, University Medical Center Regensburg, GermanyThis article was submitted to Alloimmunity and Transplantation, a section of the journal Frontiers in I... | PMC9974829 |
Methods | comorbidity | DISEASE | Analyses were conducted retroactively on a cohort of 185 consecutive patients who underwent haploidentical hematopoietic stem cell transplantation (haplo-HSCT) at Wuhan Union Medical College Hospital during the period from February 2017 to January 2019. Of these patients, 129 were randomly assigned to the training coho... | PMC9974829 |
Results | Comorbidity | DISEASE | Patients were separated into low and high CAR groups using a cutoff of 0.087, which independently predicted overall survival (OS). Based on risk factors, CAR, the Disease Risk Index(DRI), and the Hematopoietic Cell Transplantation–specific Comorbidity Index(HCT-CI), the nomogram was developed to predict OS. The C-index... | PMC9974829 |
Conclusion | CAR is an independent prognostic indicator for haplo-HSCT outcomes. Higher CAR was related to worse clinicopathologic characteristics and poorer prognoses in patients underwent haplo-HSCT. This research provided an accurate nomogram for predicting the OS of patients following haplo-HSCT, illustrating its potential clin... | PMC9974829 | ||
Introduction | hematologic malignancies, Comorbidity | DISEASE, COMPLICATION, HEMATOLOGIC MALIGNANCIES, MALNUTRITION, DISEASE CHARACTERISTIC, COMPLICATIONS | One of the most promising treatments for patients with hematologic malignancies is allogeneic hematopoietic stem cell transplantation (allo-HSCT) (It can be challenging to select patients who will benefit from HSCT because survival after transplantation can vary greatly and rely on many factors. Various factors, includ... | PMC9974829 |
Materials and methods | PMC9974829 | |||
Study patients | malignant hematologic disease | This research comprised all consecutive adult patients (aged >18 years) with malignant hematologic disease who underwent haplo-HSCT within the period of February 2017 to January 2019 at Wuhan Union Medical College Hospital. All patients who received haplo-HSCT as their initial allogeneic transplant were included in the... | PMC9974829 | |
Definitions | inflammation | INFLAMMATION | All data were collected directly within 10 days of the allo-HSCT conditioning regimen to assess the inflammatory and nutritional status before transplantation. We investigated CRP as a marker of inflammation and albumin as an indicator of nutritional status. CAR was counted by dividing the serum CRP level by the serum ... | PMC9974829 |
CRP and albumin level measurement | 5 ml of cubital vein whole blood was extracted from all patients in the morning on an empty stomach. Serum CRP level measurements were included in the routine clinical tests using an automated biochemical analyzer | PMC9974829 | ||
Donor selection, transplant regimens, and GVHD prophylaxis and treatment | Donor selection method in accordance with the non-HLA system ( | PMC9974829 | ||
Development of a prognostic model | REGRESSION | In total, 185 patients were randomized into two groups (training and validation cohorts) based on a ratio of 7 to 3. the following medical characteristics were evaluated to identify the predictive factors of survival in the training cohort: age at HSCT, sex, DRI, HCT-CI, CAR, donor–recipient relationship, donor–recipie... | PMC9974829 | |
Model validation and clinical use | The predictive capability of the nomogram was evaluated by assessing discrimination power and calibration in the training, validation, and entire cohorts. The concordance index (C-index) was computed to evaluate the discriminative ability of the novel nomogram in all cohorts. A higher C-index suggests superior capabili... | PMC9974829 | ||
Statistical analysis | Categorical features were presented as counts and proportions and examined by the chi-squared test. Continuously parameterized characteristics were reported as the median and interquartile range (IQR), and comparisons of continuous variables between cohorts were determined using the Mann–Whitney U test. In these tests,... | PMC9974829 | ||
Results | PMC9974829 | |||
Optimal cutoff of CAR for predicting all-cause mortality following haplo-HSCT | death | The median CAR among 185 patients was 0.087 (range, 0.00667–2.67352). With all-cause patient death as the outcome variable, a 3-year time-dependent ROC curve was created, and the maximum Youden index for OS was utilized to determine the optimal cutoff. The optimal cutoff of CAR was finally regarded as 0.109. Patients w... | PMC9974829 | |
Baseline clinical features of the research cohort | isohemagglutinins | The baseline clinical features of the training and validation cohorts are depicted in Patients’ baseline features.Minor ABO mismatch demonstrated the donor had isohemagglutinins against the recipient’s red blood cells, including the following blood group combinations: O (donor) into A, B, or AB (recipient); A or B (don... | PMC9974829 | |
Construction of the novel nomogram of OS | REGRESSION | In univariate analysis, OS was related to DRI (P < 0.001), HCT-CI (P = 0.038), and CAR (P < 0.001). In multivariate Cox regression analysis, DRI (P < 0.001), HCT-CI (P = 0.011), and CAR (P =0.017) were independent predictors of OS following haplo-HSCT (Univariate and multivariate Cox analysis for OS in patients with ha... | PMC9974829 | |
Validation of the novel nomogram | The C-indices of the novel nomogram for 3-year OS in the training cohort by bootstrap resampling was 0.671 (95% CI = 0.5923–0.7496). Meanwhile, it was found that the calibration plot displayed good similarity between the predicted and actual survival rates (Calibration curves for predicting 3-year OS in training cohort... | PMC9974829 | ||
Comparison of the nomograms and DRCI | Comparisons between DRCI and the nomograms were also conducted. For the three cohorts shown in the figure, the AUCs of the nomogram were greater than those of DRCI [0.715 (95% CI:0.617–0.812) Area under the ROC curves of nomogram and DRCI of OS in training cohort Comparison of the decision curves between the nomogram a... | PMC9974829 | ||
Discussion | acute myeloid leukemia, tumor, inflammation, Comorbidity, malnutrition | ACUTE MYELOID LEUKEMIA, CANCER PROGRESSION, TUMOR, PROLIFERATION, INFLAMMATION, DISEASE, INVASIVE CANCER, MYELODYSPLASTIC SYNDROMES, MALNUTRITION, HEMATOLOGICAL MALIGNANCY | DRI, HCT-CI, and CAR were the components of the developed OS nomogram. Previous studies using multivariate analysis also demonstrated significant associations between these prognostic variables and OS in patients following haplo-HSCT. Our results reconfirmed the conclusions of these investigations. In this research, we... | PMC9974829 |
Conclusion | To our knowledge, none of the existing scoring systems considers the pre-transplant inflammatory and nutritional status. This is the first study to demonstrate the predictive power of pre-transplant CAR for survival outcomes following haplo-HSCT. Compared with DRCI, the nomogram incorporating CAR displayed substantiall... | PMC9974829 | ||
Data availability statement | The original contributions presented in the study are included in the article/supplementary material. Further inquiries can be directed to the corresponding author. | PMC9974829 | ||
Ethics statement | The studies involving human participants were reviewed and approved by the Ethics Committee of Tongji Medical College of Huazhong University. The patients/participants provided their written informed consent to participate in this study. | PMC9974829 | ||
Author contributions | KW collected, analyzed the data, and wrote the paper. XJ and ZX researched the literature and revised the paper. All authors contributed to the article and approved the submitted version. | PMC9974829 | ||
Acknowledgments | The authors of this study would like to thank all the study participants for their contributions. | PMC9974829 |
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