title stringlengths 1 1.19k | keywords stringlengths 0 668 | concept stringlengths 0 909 | paragraph stringlengths 0 61.8k | PMID stringlengths 10 11 |
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PROMIS physical function | Mean change in PROMIS Physical Function score was 1.17 (95%CI -4.19, 6.53) among all participants. Participants in HIIT experienced a decline in PROMIS physical function score, whereas participants in MICE experienced an increase. | PMC10286977 | ||
Neuropathy total symptom score-6 (NTSS-6) | CIPN | Descriptive statistics indicate a change in NTSS-6 score for all participants was 0.38 (95%CI -1.39, 2.15), with participants in HIIT experiencing greater improvements in reported signs and symptoms of CIPN compared with MICE. | PMC10286977 | |
Utah early neuropathy scale (UENS) | CIPN | Change in UENS score for all participants was -0.29% (95%CI -1.31, 0.73)., with participants in HIIT experiencing greater improvements in reported signs and symptoms of CIPN compared with MICE. | PMC10286977 | |
Modified Godin leisure time physical activity questionnaire (Godin) | Results from the modified Godin revealed increases in self-reported mild-, moderate-, and strenuous-intensity MET-hrs./wk. for all participants (mild: 2.6 MET-hrs./wk., 95%CI -0.29, 5.49; moderate: 9.0 MET-hrs./wk, 95%CI 1.07, 16.9; strenuous: 3.4 MET-hrs./wk, 95%CI -3.49, 10.3). Among participants in HIIT, increases w... | PMC10286977 | ||
Discussion | cancer, CRC, breast cancer | RECRUITMENT, BREAST CANCER, ADVERSE EVENTS, CANCER, MINOR, SECONDARY | Among the seven participants in our trial, we found that stage II-III CRC survivors’ post-resection and adjuvant therapy tolerated and expressed acceptability for an mHealth, home-based exercise intervention. We observed an 88.6% completion rate of prescribed workouts, 100% retention rate, no adverse events, and qualit... | PMC10286977 |
Conclusion | cancer, CRC | CANCER | Our findings indicate an mHealth, home-based delivered exercise intervention, including a HIIT prescription, among stage II-III CRC survivors’ post-resection and adjuvant therapy was tolerable and showed trends towards acceptability. Our qualitative data revealed that survivors wanted to work out harder/do more. Collec... | PMC10286977 |
Supporting information | PMC10286977 | |||
CONSORT 2010 checklist of information to include when reporting a randomised trial*. | (DOC)Click here for additional data file.(XLSX)Click here for additional data file.(PDF)Click here for additional data file.We would like to thank the individuals who participated in our trial. | PMC10286977 | ||
References | PMC10286977 | |||
Key Points | PMC10152305 | |||
Question | stroke | STROKE | In the first 6 months after a stroke, is there an association between physical activity trajectories and functional recovery? | PMC10152305 |
Findings | poststroke, stroke | STROKE | In this cohort study of 1367 participants who were stratified into 2 physical activity trajectory groups of increaser and decreaser, males and those with normal cognition had a higher likelihood of increasing and sustaining poststroke physical activity, regardless of stroke severity. Increased and sustained activity po... | PMC10152305 |
Meaning | stroke | STROKE | Findings of this study suggest that interventions targeting individuals with decreasing physical activity in the subacute phase of stroke may play a role in improved functional outcomes. | PMC10152305 |
Importance | poststroke | The optimum level and timing of poststroke physical activity interventions to enhance functional recovery remain unclear. | PMC10152305 | |
Objective | stroke | STROKE | To assess the level of physical activity in the first 6 months after stroke among individuals with similar physical activity patterns over time and to investigate the association between physical activity trajectories and functional recovery at 6 months after stroke. | PMC10152305 |
Design, Setting, and Participants | stroke, Stroke | STROKE, STROKE | This cohort study obtained data from the Efficacy of Fluoxetine–a Randomized Controlled Trial in Stroke, which was conducted in 35 stroke and rehabilitation centers across Sweden from October 2014 to June 2019. Adult participants (aged >18 years) were recruited between 2 and 15 days after stroke onset and followed up f... | PMC10152305 |
Exposures | REGRESSION | Physical activity was assessed at 1 week, 1 month, 3 months, and 6 months. Multiple factors associated with physical activity trajectories were investigated. Association of the distinct trajectories with functional recovery was assessed in multivariable logistic regression. | PMC10152305 | |
Main Outcomes and Measures | stroke | STROKE, SECONDARY | The primary outcomes were the distinct physical activity trajectories over time, which were identified using group-based trajectory modeling. The secondary outcome was the functional recovery at 6 months after stroke, which was assessed using the modified Rankin Scale. | PMC10152305 |
Results | Of the 1367 included participants (median [IQR] age, 72 years [65-79] years; 844 males [62%]), 2 distinct trajectory groups were identified: increaser (n = 720 [53%]) and decreaser (647 [47%]). The increaser group demonstrated a significant increase in physical activity level (mean difference, 0.27; linear slope β | PMC10152305 | ||
Conclusions ad Relevance | stroke | STROKE | Results of this study suggest that increased physical activity was associated with functional recovery 6 months after stroke. Interventions targeting individuals with decreasing physical activity in the subacute phase of stroke may play a role in improved functional outcomes. | PMC10152305 |
Introduction | stroke | STROKE, CARDIOVASCULAR DISEASE | The health benefits of physical activity have been proven to considerably reduce the risk of all-cause mortality and cardiovascular disease, including stroke.Patients with stroke are susceptible to being less active than older adults with nonneurological chronic conditions, especially compared with healthy older indivi... | PMC10152305 |
Methods | PMC10152305 | |||
Study Population and Design | neurological deficit, stroke, hemorrhagic stroke, Stroke | STROKE, HEMORRHAGIC STROKE, STROKE | Longitudinal data of the study participants were prospectively collected from the Efficacy of Fluoxetine—a Randomized Controlled Trial in Stroke (EFFECTS), a multicenter, placebo-controlled, double-blind randomized clinical trial that assessed the safety and efficacy of fluoxetine for functional recovery after stroke i... | PMC10152305 |
Clinical Measurements | death, stroke, stroke-related comorbidities, disability, diabetes | STROKE, CORONARY ARTERY DISEASE, DIABETES | Baseline characteristics included age, sex, socioeconomic factors (living arrangements, educational level, and employment status), stroke type, stroke-related comorbidities (coronary artery disease and diabetes) and use of antihypertensive, antihyperlipidemic, anticoagulant, and antiplatelet drugs, and the total number... | PMC10152305 |
Statistical Analysis | PMC10152305 | |||
Physical Activity Trajectories | Participants were excluded from the analysis if they were missing data on more than 30% of the outcome measures or if they had 2 or more missed follow-ups. The primary outcomes were the distinct physical activity trajectories over time. Physical activity trajectories were identified using group-based trajectory modelin... | PMC10152305 | ||
Functional Outcome | stroke | REGRESSION, STROKE, SECONDARY | The secondary outcome was the functional outcome 6 months after stroke, which was assessed using mRS scores. The scores were dichotomized into 2 groups: good outcome (0-2) vs poor outcome (3-6). Logistic regression models were applied to assess the association between trajectory groups and functional recovery while adj... | PMC10152305 |
Results | stroke | STROKE | Of the 1497 included participants with stroke at baseline, 46 died within 6 months. After excluding those who withdrew (n = 11) or were lost to follow-up (n = 119), the longitudinal study sample comprised 1367 participants with 5146 assessments (eFigure 1 in | PMC10152305 |
Baseline Demographic Characteristics of the Study Population and by the Trajectory Group | diplopia, hemorrhagic stroke, Stroke, fatigue, stroke, anterior circulation stroke, CAD, aphasia | DIPLOPIA, HEMORRHAGIC STROKE, STROKE, STROKE, LACUNAR STROKE, POSTERIOR CIRCULATION STROKE, CORONARY ARTERY DISEASE, CAD | Abbreviations: CAD, coronary artery disease; LACS, lacunar stroke; mRS, modified Rankin Scale; NIHSS, National Institutes of Health Stroke Scale; OCSP, Oxfordshire Community Stroke Project; PACS, partial anterior circulation stroke; POCS, posterior circulation stroke; SGPALS, Saltin-Grimby Physical Activity Level Scale... | PMC10152305 |
Increaser and Decreaser Groups Stratified by Physical Activity Patterns Over Time | A, The increaser group had a significant increase in physical activity and sustained it at light intensity. The decreaser group had a significant decline in physical activity and became inactive. Shading represents CIs. B, The increaser group had a significant decrease in inactivity from 1 week to 6 months after random... | PMC10152305 | ||
Multivariable Logistic Regression of Covariates Associated With Good Functional Outcome at 6 Months After Stroke | CAD, Stroke | STROKE, CORONARY ARTERY DISEASE, CAD | Abbreviations: aOR, adjusted odds ratio; CAD, coronary artery disease; NA, not applicable; NIHSS, National Institutes of Health Stroke Scale; OR, odds ratio.The increaser group had a significant increase in physical activity from 1 week to 6 months after randomization and sustained it at light intensity.Model fit stati... | PMC10152305 |
Association of Increased Physical Activity and Sustained Light-Intensity Activity With Good Outcomes at 6 Months | disability | Eight participants were excluded due to missing mRS data at 6 months (1 withdrew; 7 were lost to follow-up). Of the 1359 participants, 890 (65%) had a good outcome and 469 (35%) had a poor outcome at the 6-month assessment. Among the participants with a good outcome, 544 (61%) were in the increaser group and 346 (39%) ... | PMC10152305 | |
Distribution of the Increaser and Decreaser Groups by the Modified Rankin Scale Score | There were significant differences between the increaser and decreaser groups with modified Rankin Scale scores of 0, 1, 2, 3, 4 and 5, but not 6.Covariates associated with functional outcomes at 6 months are shown in | PMC10152305 | ||
Discussion | poststroke, stroke, gain | STROKE | In this longitudinal and prospective cohort study, 2 distinct physical activity trajectories were identified. The increaser group increased their physical activity and sustained it at light intensity, while the decreaser group decreased their physical activity and became inactive. Male participants and those with norma... | PMC10152305 |
Limitations | prestroke, stroke, mild-to-moderate stroke | STROKE | This study has several limitations. First, there was a high proportion of participants with mild stroke, which may limit the generalizability of the findings to populations with mild-to-moderate stroke severity. This situation may also limit the ability to replicate the study findings. Second, although group-based traj... | PMC10152305 |
Conclusions | stroke | STROKE | This large longitudinal, prospective cohort study found that increased physical activity sustained at light intensity for more than 4 hours per week during the subacute phase of stroke was associated with a good outcome at 6 months. Males and patients with normal cognition had a higher likelihood of increasing their ph... | PMC10152305 |
Background | postoperative pain, gastrointestinal (GI) function | This prospective randomized controlled study was designed to evaluate the effect of S-ketamine with sufentanil given intraoperatively and postoperatively on recovery of gastrointestinal (GI) function and postoperative pain in gynecological patients undergoing open abdomen surgery. | PMC10061816 | |
Methods | postoperative pain, nausea and vomiting | ADVERSE EVENTS, SECONDARY | One hundred gynecological patients undergoing open abdomen surgery were randomized into an S-ketamine group (group S) or placebo group (0.9% saline; group C). Anesthesia was maintained with S-ketamine, sevoflurane, and remifentanil-propofol target-controlled infusion in group S and with sevoflurane and remifentanil-pro... | PMC10061816 |
Results | SD | The time of first postoperative flatus in group S was significantly shorter (mean ± SD, 50.3 ± 13.5 h) than that in group C (mean ± SD, 56.5 ± 14.3 h, | PMC10061816 | |
Conclusions | postoperative pain | S-ketamine accelerated postoperative GI recovery and reduced 24 h postoperative pain in patients undergoing open gynecological surgery. | PMC10061816 | |
Trial registration | SECONDARY | ChiCTR2200055180. Registered on 02/01/2022. It is a secondary analysis of the same trial. | PMC10061816 | |
Keywords | PMC10061816 | |||
Introduction | postoperative pain, acute pain, pain | Opioids remain the most commonly prescribed painkillers for treating severe pain [In recent years, the use of ketamine as part of a multimodal analgesia approach to treating acute pain with fewer side effects has gained considerable interest [NMDA receptors have an important role in the intrinsic neuronal control of GI... | PMC10061816 | |
Methods | PMC10061816 | |||
Participants | comorbidity, hepatorenal dysfunction, epilepsy, multiple primary malignant tumors, dementia, diabetes, ovarian cyst rupture, gynecologic disease, schizophrenia, gynecological cancer, Cancer | UNCONTROLLED HYPERTENSION, GYNECOLOGIC DISEASES, ENDOMETRIOSIS, HEMOPERITONEUM, PELVIC INFLAMMATORY DISEASE, EPILEPSY, RECRUITMENT, DIABETES, OVARIAN CYST RUPTURE, CHRONIC PAIN, TUMOR RECURRENCE, CANCER | The double-blind, prospective randomized controlled trial was conducted in a tertiary hospital in Beijing, China. This study was approved by the Institutional Review Board at Peking University Cancer Hospital’s Ethics Committee (No.2021YJZ109) and written informed consent was obtained from all subjects participating in... | PMC10061816 |
Anesthetic and analgesic techniques | blood loss | BLOOD LOSS | Patient monitoring in the operating room was performed using electrocardiography, pulse oximetry, end-tidal carbon dioxide, invasive arterial pressure, urine output, and the bispectral index (BIS). All patients received general anesthesia induced by intravenous administration of 2 mg/kg of propofol, 0.4 μg/kg of sufent... | PMC10061816 |
Postoperative data collection | nausea, Postoperative pain, vomiting, pain, dizziness | ADVERSE EVENTS | Postoperative pain at rest was assessed using the VAS (ranging from 0 to 10, 0 = no pain, 10 = the worst imaginable pain). Patients received 0.1 μg/kg of sufentanil administered by an anesthesiologist to achieve a VAS score ≤ 3 before discharge from the post-anesthesia care unit. If the VAS score > 3, 0.1 μg/kg sufenta... | PMC10061816 |
Sample size | In a preliminary trial that we conducted, the mean of first postoperative flatus time in patients who accepted additional use of S-ketamine was 2.01 days, the standard deviation (SD) was 0.736. The mean of first postoperative flatus time in patients without S-ketamine was 2.54 days, the SD was 0.694. According to PASS ... | PMC10061816 | ||
Statistical analysis | All statistical analyses were performed using Statistical Package for the Social Sciences (SPSS) version 20.0 software (IBM Corp. Released 2011. IBM SPSS Statistics for Windows, Version 20.0. Armonk, NY: IBM Corp.). Continuous variables with normal distribution are presented as mean ± SD. Non-normal variables are prese... | PMC10061816 | ||
Discussion | postoperative pain, GI disturbance, nausea and vomiting, hallucinations, dizziness, pain | CAVITY | Our preliminary experiment found that the use of S-ketamine shortened patients’ first occurrence of flatus time after surgery by about 0.5 days. This interesting phenomenon has not been previously reported and thus we set the time of first postoperative flatus as the primary outcome in our current study. The randomized... | PMC10061816 |
Conclusions | pain | In summary, our study provides evidence that an adjunct of S-ketamine shortens the time to the first passage of flatus in patients undergoing gynecological abdominal surgery and is effective for decreasing the intensity of pain within the first 24 h after surgery. | PMC10061816 | |
Acknowledgements | We thank the gynecologist and anesthetist for collaboration in the surgical procedures. | PMC10061816 | ||
Authors’ contributions | HY Tan, HL | TZ Zhang designed, performed the experiments, analyzed the data and wrote the manuscript. ZJ Yue designed, interpreted the data, and revised the manuscript. L Yu designed, performed the experiment and revised the manuscript. S Li, YN Xie, and J Wei analyzed the literature research, and revised the manuscript. MG Wu and... | PMC10061816 | |
Funding | This study was supported by Wu Jieping Medical Foundation (Beijing, China. No. 320.6750.2021–4-18). The funders had no role in the study design, data collection, analysis, decision to publish, or preparation of the manuscript. | PMC10061816 | ||
Availability of data and materials | The datasets used and/or analysed during the current study available from the corresponding author on reasonable request. | PMC10061816 | ||
Declarations | PMC10061816 | |||
Ethics approval and consent to participate | Cancer | CANCER | Ethical approval was obtained from the Institutional Review Board at Peking University Cancer Hospital’s Ethics Committee (No.2021YJZ109) address: Peking University Cancer Hospital’s Ethics Committee, No. 81 Fucheng Street, Haidian District, Beijing, China. The trial was registered in the Chinese Clinical Trial Registr... | PMC10061816 |
Consent for publication | Not applicable. | PMC10061816 | ||
Competing interests | The authors declare that they have no competing interests. | PMC10061816 | ||
References | PMC10061816 | |||
Background | limb motor dysfunction, Stroke | STROKE | Stroke’s prevalence and morbidity are increasing (Guano, et al. Neuro 89:53–61, 2017), and limb motor dysfunction is left in most patients (Gittler, et al. JAMA 319:820–821, 2018). Particularly, the rehabilitation of upper limbs is more difficult and time-consuming (Borges, et al. The Cochrane database of systematic re... | PMC10174617 |
Methods | stroke, Stroke, upper limb motor dysfunction, PES | STROKE, SECONDARY, STROKE | A double-blind randomized controlled trial (RCT) will be conducted to investigate whether a new functional electrical stimulation (FES) combined with acupoint therapy is more effective in the rehabilitation of upper limb motor dysfunction after stroke. Patients who meet the inclusion criteria will be randomly divided i... | PMC10174617 |
Discussion | stroke, upper limb motor function | STROKE | The results of this study are expected to verify the efficacy of PES therapy in the rehabilitation of upper limb motor function after stroke. This may promote the widespread use of the therapy in hospitals, communities, and homes for early and continuous treatment. | PMC10174617 |
Trial registration | ClinicalTrials.gov NCT05333497. Registered on April 11, 2022. | PMC10174617 | ||
Keywords | PMC10174617 | |||
Introduction | death, stroke, cord injury, Acupuncture, motor disorders, hemiplegia, disability | MOTOR DISORDERS, STROKE, DISEASE, ADVERSE EVENTS | Global Burden of Disease (GBD) has indicated that stroke is the leading cause of death and disability among adults in China [FES is commonly used in patients with motor disorders such as stroke, spinal cord injury, and hemiplegia. The possible mechanism is mainly brain remodeling and activity-dependent plasticity [Acup... | PMC10174617 |
Methods | PMC10174617 | |||
Pre-design | muscle fatigue | Five healthy subjects and five patients are selected to conduct a survey on the comfort of this instrument parameters, body position, stimulation time, muscle fatigue, completion of programmed movements, and other conditions and to refine the trial design in response to feedback and comments from participants. | PMC10174617 | |
Study design | stroke, Stroke, PES, ’ | STROKE, STROKE | This clinical trial is designed as a double-blind RCT with 90 participants (60 stroke patients and 30 healthy controls) to be recruited. SPIRIT checklist and CONSORT statement were used when writing this study protocol [Flow diagram of the whole trial (details of patients’ and healthy controls’ groups in Figs. Flow dia... | PMC10174617 |
Study setting | stroke, Acupuncture | STROKE | The patients are stroke inpatients meeting the inclusion criteria in Acupuncture and Moxibustion Ward 3 of the Second Affiliated Hospital of Heilongjiang University of Chinese Medicine in Harbin, China. This hospital is the highest level one in China. | PMC10174617 |
Patients and healthy controls | All the 60 eligible patients will be recruited through clinic centers, hospital announcements, and China’s pubic social network platform (The healthy controls only need the detection of sEMG and EEG. Neither patients nor healthy controls will be involved in the design, conduct, or data processing of this study. The inc... | PMC10174617 | ||
Interventions | DISEASE | All patients received conventional medication, rehabilitation, and acupuncture. As informed, during the study period, any other Chinese and Western medicine or treatment care related to this disease will not be permitted without the approval from the trial staff in advance. | PMC10174617 | |
CES group | PES | Based on the conventional treatment in the Department of Acupuncture, the output mode of the fourth generation of low-frequency acupoint electric stimulation instrument of the original program will be adopted to synchronously stimulate the flexor and extensor acupoints respectively. The selection of acupoints, treatmen... | PMC10174617 | |
Healthy control group | No treatment, as the baseline. Ask them to do the “reaching and retrieving” gross motion and record the resting state EEG and motion state sEMG parameters.All the patients will receive free medical care during the study period, including counseling, therapy, electrophysiology, and scale evaluation. Participation in the... | PMC10174617 | ||
Randomization and blinding | BLIND | A random grouping method will be adopted. The SPSS 26.0 statistical software is used to randomly generate serial numbers and groups, and blind selection cards are made and put into envelopes (with no difference in appearance). Numbers are according to the inclusion sequence of the subjects, and corresponding experiment... | PMC10174617 | |
Outcome measures | PMC10174617 | |||
Primary outcome measures | The primary outcomes are real-time sEMG signals [ | PMC10174617 | ||
Patients | TB | Before and after the first and last treatment, the immediate alpha, beta, delta, and theta bands of the eyes-closed resting state EEG of patients in the two groups and ask the patients to do the “reaching and retrieving” gross motion, recording the real-time sEMG data of RMS (root mean square) and MF (median frequency)... | PMC10174617 | |
Healthy controls | TB | Before the beginning of the whole clinical trial, the immediate alpha, beta, delta, and theta bands of the eyes-closed resting state EEG of the healthy controls in a quiet, without any interference laboratory will be recorded and ask them to do the “reaching and retrieving” gross movement, recording the real-time sEMG ... | PMC10174617 | |
Secondary outcome measures | SECONDARY | Before and after the whole trial, the secondary outcome variables including MBI (a daily functional activity assessment) [ | PMC10174617 | |
Sample size estimation | Sample size estimation was carried out according to the study objectives and protocol, and the difference between RMS values of sEMG of BB was obtained from the pretest of group 1 and group 2 after treatment and the healthy group. The difference between the healthy group and group 1 was 167.61 and 68.17 for group 2, an... | PMC10174617 | ||
Management and safety monitoring | CRF | CRF | Before the initiation of this trial, the feasibility and innovation of this protocol have been discussed comprehensively in the seminar composed of five authoritative experts in the field. Then, the task will be divided, and the relevant personnel should receive training. To prevent treatment bias, all the staff includ... | PMC10174617 |
Trial conduct auditing | In order to timely discover and solve the problems encountered in the study duration, the Project Management Group will check the trial records and hold a group meeting to review trial conduct twice a week. Meanwhile, the Trial Steering Group (including acupuncture and rehabilitation physicians, instrument engineer, an... | PMC10174617 | ||
Data statistical analysis | The SPSS 26.0 statistical software will be used for analysis by three-party statisticians. Data presentation: each measurement is presented as mean ± standard deviation if it conforms to a normal distribution, or median and quartiles if it does not. Intra-group comparisons: if the measurement data in each group conform... | PMC10174617 | ||
Responsibilities of each trial groups | BLIND | Under the guidance of the study director, the trial design group extensively reviews references and information about the subject, designs and adjusts the trial protocol, and collates the clinical data. Detailed information from ward feedback is collected daily, summarized and recorded, and reported to the director twi... | PMC10174617 | |
Discussion | stroke, extensor coordination disorder | STROKE, CONTRACTION | In the process of motor function recovery in stroke patients, flexor and extensor coordination disorder is a common symptom [Rehabilitation of the upper limbs is difficult and time-consuming. This instrument is combined with the advantages of FES and acupoints. By stimulating the corresponding acupoints of the active a... | PMC10174617 |
Trial status | RECRUITMENT | The recruitment began on 3 June 2022 and is expected to last for 2 months (version date: 2021.11.19, version number: V1.1). | PMC10174617 | |
Acknowledgements | We would like to thank Prof. Dongyan Wang (PhD, doctoral supervisor, chief physician, professor, vice president of the Second Affiliated Hospital of Heilongjiang University of Chinese Medicine and the inventor of the instrument in this trial) for the important guidance and monitoring in this trial. We also give many th... | PMC10174617 | ||
Authors’ contributions | YL is the first author, translator, and responsible for this trial overall. DW is the director, commander-in-chief, and sponsor of this trial. XD, LF, and DT give advice on the design and supervision of the operation. HH undertakes the revision and final review of this paper. JL and HZ provide skill support. YZ and SW ... | PMC10174617 | ||
Funding | Supported by grants from the Natural Science Foundation of Heilongjiang Province (LH2019H113) and the “Outstanding Innovative Talents Support Program” Scientific Research Project of Heilongjiang University of Chinese Medicine (person in charge: Dongyan Wang). | PMC10174617 | ||
Availability of data and materials | Trial data are available on reasonable non-commercial request to the investigator of the study. | PMC10174617 | ||
Declarations | PMC10174617 | |||
Ethics approval and consent to participate | ADVERSE REACTIONS, RECRUITMENT | The protocol has been approved, and the informed consent has been reviewed by the Ethics Committee of the Second Affiliated Hospital of Heilongjiang University of Chinese Medicine (approval number: IRB-AF/SG-18/01.0), with further monitoring routinely including the results. All participants will sign the informed conse... | PMC10174617 | |
Consent for publication | All the authors have approved the publication of this manuscript. | PMC10174617 | ||
Competing interests | The authors declare that they have no competing interests. | PMC10174617 | ||
References | PMC10174617 | |||
Abstract | PMC9870741 | |||
Background | T2DM | TYPE 2 DIABETES MELLITUS | All‐cause mortality risk prediction models for patients with type 2 diabetes mellitus (T2DM) in mainland China have not been established. This study aimed to fill this gap. | PMC9870741 |
Methods | T2DM | Based on the Shanghai Link Healthcare Database, patients diagnosed with T2DM and aged 40‐99 years were identified between January 1, 2013 and December 31, 2016 and followed until December 31, 2021. All the patients were randomly allocated into training and validation sets at a 2:1 ratio. Cox proportional hazards models... | PMC9870741 | |
Results | heart failure, deaths, cancer, T2DM | KIDNEY DISEASE, CANCER, LIVER DISEASE, HEART FAILURE, CEREBROVASCULAR DISEASE | A total of 399 784 patients with T2DM were eventually enrolled, with 68 318 deaths over a median follow‐up of 6.93 years. The final prediction model included age, sex, heart failure, cerebrovascular disease, moderate or severe kidney disease, moderate or severe liver disease, cancer, insulin use, glycosylated hemoglobi... | PMC9870741 |
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