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4. ERGEBNISSE 5. AUSWERTUNG Die Boxplots in den oberen beiden Abbildungen zeigen jeweils für 10 und 12 Uhr die Reaktionszeiten und Genauigkeitswerte des N-Back- und des spatial work ing memory updating Test bei den jeweiligen Lichtszenen. Weder um 10, noch um 11 Uhr konnten signifikante Unterschiede bei den Audioreaktionszeiten und den Genauigkeiten zwischen den Lichtszenen nach der Exposition gefunden werden. Ein Vergleich der Mittelwerte zeigte, dass um 12 Uhr die Genauigkeits werte des spatial working memory updating Tests unter der frontalen Beleuch tung des Gesichtsfeldes (Lichtszene 1+2; M = .660, SD = .114) höher sind als unter der konventionellen Beleuchtungssituation (Lichtszene 3; M = .540, SD = .089). 6. FAZIT In dieser Studie zeigte sich kein statistisch signifikanter Unterschied zwischen den untersuchten Lichtszenen und den Reaktionszeiten oder Genauigkeitswer ten der kognitiven Leistungstests. Die Hypothese konnte nicht bestätigt werden. Die Ergebnisse beeinflussende Faktoren: Tageszeit / Chronotyp: NIF-Wirkungen tagsüber moderater ausgeprägt; cir cadianer Leistungsgang Lichthistorie: Versuchsdurchführung im Sommer - längere vorherige Tages lichtexposition als im Winter Psychologische Leistungstests: Schwierigkeitsgrad, Art der Durchführung (Laptop, Tablet, etc.) Dauer der Lichtexposition: hier nur kurzzeitige Exposition; möglicherweise nicht ausreichend für die messbare Ausprägung der NIF-Effekte 1. EINFÜHRUNG Nicht-visuelle Effekte des Lichts (englisch: non-image-forming, NIF), werden durch ein Zusammenspiel der photosensitiven Sinneszellen in der Netzhaut beeinflusst. Unter den photosensitiven Sinneszellen wird den intrinsisch pho tosensitiven retinalen Ganglienzellen (englisch: intrisically photosenitive Re tinal Ganglion Cell, ipRGC) eine besondere Rolle zugeschrieben. Direkt mit der Lichtwirkung auf diese Zellen verknüpfte Wirkungen, wie z.B. die Melatoninun terdrückung, werden auch als ipRGC-beeinflusste Lichtwirkungen (englisch: ipRGC-influenced light effects, IIL) bezeichnet. Ein gut untersuchter Zusam menhang einer IIL-Wirkung besteht zwischen der Lichtexposition und dem zeit lichen Konzentrationsverlaufs des nur während der Nacht vorhandenen Hor mons Melatonin. Einige Studien zeigen einen Einfluss der Lichteinfallsrichtung. Licht aus dem oberen Gesichtsfeld, das auf die untere Netzhauthälfte fällt, führ te zu einer stärkeren Melatoninunterdrückung. Der Einfluss der Lichteinfalls richtung auf andere NIF-Effekte während der Nacht, wie z.B. Phasenverschie bung, Körperkerntemperatur und subjektive Schläfrigkeit, wurde bisher nur von einzelnen Studien untersucht. Am Tag wurde dies noch nicht untersucht. 2. ZIEL Ziel dieser Arbeit ist zu untersuchen, ob und welcher Einfluss sich durch ver schiedene räumliche Lichtverteilungen am Tag auf kognitive Leistungstests zeigt. Konkret soll die Hypothese untersucht werden: Licht aus Region 1+2 steigert tagsüber die Genauigkeit und senkt die Reaktionszeiten der kognitiven Leistungstests. 3. METHODE In einem speziellen LED-hinterleuchteten büroähnlichen Lichtsimulatorraum der TU Berlin wurde eine Probandenstudie (N=10, w=3) durchgeführt. Dazu wurden zwei Lichtszenen eingerichtet: in der einen Lichtszene trifft das Licht hauptsächlich aus dem oberen Gesichtsfeld und in der anderen Lichtszene hauptsächlich aus dem unteren Gesichtsfeld auf das Auge des Probanden. Gemeinsam haben die Lichtszenen eine Beleuchtungsstärke von 1000 lx am Auge (Emel,v=160 µW/cm²) und einer ähnlichsten Farbtemperatur von 6200 K bei einem Farbwiedergabeindex von ca. 80 (siehe Abb. 1). Die Durchführung fand für die eine Hälfte der Probanden um 10 Uhr und für die andere 11 Uhr im Abstand je einer Woche statt. Innerhalb der beiden Gruppen wurden die Licht szenen jeweils als gegenbalanciertes Cross-Over-Design durchgeführt. Jeweils vor und nach der Lichtexposition wurde ein Fragebogen ausgefüllt und ein Audioreaktionszeittest, sowie zu Beginn und als Abschluss der Expositions zeit ei | poster |
ExaFMM: An open source library for Fast Multipole Methods aimed towards Exascale systems Lorena A Barba1, Rio Yokota2 1 Boston University, 2 KAUST Left — The simulation of homogeneous isotropic turbulence is one of the most challenging benchmarks for computational fluid dynamics. We have matched the current world record in turbulence simulation, computing a 40963 system on 4096 GPUs with our fast multipole vortex method. This simulation achieved 1 petaflop/s on Tsubame 2.0. Below — Scaling on a massively parallel CPU systems is also excellent. The plot shows MPI weak scaling (with SIMD within each core) from 1 to 32,768 processes, and timing breakdown of the different kernels, tree construction and communications. The test uses 10 miilion points per process, and results in 72% parallel efficiency on 32 thousand processes (Kraken system). GPU Technology Conference, May 2012 What’s new? An open source FMM Want more? Papers and software are online P2P M2L M2P 0 50 100 150 200 250 300 350 GFlops N=104 N=105 N=106 N=107 Left — Actual performance on the GPU of three core kernels, for four different values of N. The M2P kernel of the treecode is able to deliver more flop/s on GPU than the M2L kernel of the FMM. M2M multipole to multipole treecode & FMM M2L multipole to local FMM L2L local to local FMM L2P local to particle FMM P2P particle to particle treecode & FMM M2P multipole to particle treecode source particles target particles information moves from red to blue P2M particle to multipole treecode & FMM Results: Parallel, multi-GPU performance Besides the results shown above, strong scaling runs on CPUs for 10 million bodies per core have shown 93% parallel efficiency at 2048 cores without SIMD, and 54% parallel efficiency at 2048 cores with SIMD kernels. Strong scaling runs on GPUs for 100 million bodies show 65% parallel efficiency on 512 GPUs, while weak scaling runs on GPUs with 4 million bodies per GPU show 72% parallel efficiency on 2048 GPUs. The calculation of isotropic turbulence on a 20483 grid (as shown in the figure above) uses 4 million bodies per GPU on 2048 GPUs. The same calculation using FFTW on 2048 CPU cores of the same machine obtains 27% parallel efficinecy on 2048 cfores. The good scalability of FMMs becomes an advantage on massively parallel systems. All the codes developed in our group are free (like free beer) and open source. To download them, follow the links from our group website: http://barbagroup.bu.edu Also on the website are up-to-date bibliographic references, and papers for download. Please visit! pop stack split cell multipole acceptance criterion push to stack calculate interaction calculate interaction target tree source tree push root pair to stack Initial step Iterative step 1 8 64 512 4096 32768 0 10 20 30 40 Nprocs time [s] tree construction mpisendp2p mpisendm2l P2Pkernel P2Mkernel M2Mkernel M2Lkernel L2Lkernel L2Pkernel 1/16 1/8 1/4 1/2 1 2 4 8 16 32 64 128 256 16 32 64 128 256 512 1024 2048 Operational intensity (flop/byte) Attainable flop/s (Gflop/s) no SFU, no FMA +SFU +FMA Fast N-body (particle-particle) Fast N-body (cell-cell) 3-D FFT Stencil SpMV single-precision peak The fast multipole method (FMM) is a numerical engine used in many applications, from acoustics, electrostatics, fluid simulations, wave scattering, and more. Despite its importance, there is a lack of open community code, which arguably has affected its wider adoption. It is also a difficult algorithm to understand and to program, making availability of open-source implementations even more desirable. Method: Multipole-based, hierarchical There are two common variants: treecodes and FMMs. Both use tree data structures to cluster ‘source particles’ into a hierarchy of cells. See Figure to the right. Multipole expansions are used to represent the effect of a cluster of particles, and are built for parent cells by an easy transformation (M2M). Local expansions are used to evaluate the effect of multipole expansions on | poster |
***Este documento está clasificado como PUBLICO por TELEFÓNICA. ***This document is classified as PUBLIC by TELEFÓNICA. Providing Secure NFV Multi-Site Connectivity Services DESCRIPTION OF COMPONENTS AND ARCHITECTURE VALIDATION OF THE SCENARIO PoC TEAM MEMBERS FISHY EU PROJECT L2S platform offers an abstraction of a layer-2 switch with VLANs support that spans multiple NFV sites. In addition, it protects data communications among NFV sites using standards protocols and state-of-the-art open-source technologies (such as VXLAN, or IPsec), preserving isolated operations of multi-site NFV services. The Centrally Controlled IPSec (CCIPS) goes beyond the classical point to point IPsec setup and provides a centralized architectural solution to control multiple IPsec endpoints or gateways. This solution is composed of a centralized E2E manager (controller) and two or more agents, based on IPsec engine in IKE-less mode (no IKE protocol is needed). @H2020FISHY https://www.linkedin.com/in/fishy-project- 16342920a/ • CCIPS agents orchestrated by CCIPS controller • Data and control nodes • Encryption algorithms • Lifetimes for SA • Events • CCIPS on • Rekey • CCIPS off • Traffic increases due to the exchange of encrypted packets https://fishy-project.eu/ FISHY has received funding from the European Union’s Horizon2020 Research and Innovation Programme, under grant agreement no. 952644 Control events Data traffic (TCP) | poster |
RESULTS Eighty-two children (mean age 8.6±3.5 years) were studied between Dec-2021 to Dec-2022; 60 with a molecular-documented previous COVID-19 (Group A) and 22 without previous infection defined as the absence of antigen-specific antibodies before the vaccination (Group B). Overall, 44 were healthy children (HC), 20 were immune compromised (IC), and 18 had a previous diagnosis of MIS-C (MIS-C). Title: mRNA vaccine elicits a higher humoral response in children with a previous COVID-19 with an overall median S-RBD IgG, Parental, and Omicron NAbs in Group A 5, 18, and 28-fold higher than Group B (p<0.0001) (Fig.1) Costanza Di Chiara1,2§, Anna Cantarutti3§, Francesco Bonfante4, Maria Raffaella Petrara1, Chiara Cosma1, Matteo Pagliari4, Nicola Cotugno5, Alessandra Meneghel1, Elisa Benetti1, Luca Bosa1, Paolo Palma5, Anita De Rossi1, Carlo Giaquinto1,2, Daniele Donà1,2§, Andrea Padoan1§, for the VERDI study team mRNA Vaccines Induce a Higher Antibodies Response in Children With Previous COVID-19 CONCLUSIONS We observed that mRNA vaccination triggers a higher humoral response in children with a previous history of COVID- 19, regardless of the immune deficiency or previous MIS-C, providing insight into boosting preexisting immunity with mRNA vaccines. Moreover, antibodies declined from 1 to 6 mo after vaccination in both groups. 0841 BACKGROUND mRNA vaccines trigger an higher magnitude and durability of humoral response to SARS-CoV-2 in adults after a previous infection compared to infection- naïve people. However, data are lacking in the pediatric population. This study aimed to evaluate the early and long-term immune response after the BNT162b2 monovalent vaccine in children aged 5-11 years with or without a previous SARS-CoV-2 infection. METHODS Multi-centre, prospective, observational study evaluating the immune response to SARS-CoV-2 in children aged 5-11 years attended the Pediatric Departments at the University of Padua and Bambino Gesù Children’s Hospital in Rome (Italy); Volunteers underwent three immunological follow-up (pre-vaccination and 1 month (mo), and 6 mo after the second dose); a blood sample was collected during each visit for the characterization of the immune profile; Neutralizing antibodies (Nabs) and anti-S-RBD IgG titers were analyzed through Plaque Reduction Neutralization Test (PRNT) and chemiluminescent immune-enzymatic assay (CLIA), respectively. B and T cell phenotypes were analyzed by flow cytometry; Geometric mean titers (GMTs) and 95% CI and median and IQR of variables were evaluated according to pre- existing confirmed COVID-19. §contributed as co-first and co-last authors 1 University of Padova, Padova, Italy; 2 Penta – Child Health Research, Padova, Italy; 3 University of Milano-Bicocca, Milan, Italy; 4 Istituto Zooprofilattico Sperimentale delle Venezie, Padova, Italy; 5 Bambino Gesù Children's Hospital, IRCCS, Rome, Italy. Department of Systems Medicine, University of Rome “Tor Vergata”, Rome, Italy. Fig.1 Fig.2 Panel A Panel B Panel C 0 1000 2000 3000 4000 5000 6000 1 mo. 6 mo. S-RBD IgG kBAU/L Median Time from Vaccine Healthy IT MIS-C Healthy IT Group A Group B 0 1000 2000 3000 4000 5000 6000 7000 1 mo. 6 mo. Reciprocal of PRNT50 (Parental) GMT Time from Vaccine Healthy IT MIS-C Healthy IT Group A Group B 0 100 200 300 400 500 600 700 800 900 1000 1 mo. 6 mo. Reciprocal of PRNT50 (BA.2) GMT Time from Vaccine Healthy IT MIS-C Healthy IT Group A Group B Fig.2 Similarly, T-regs and B-regs were higher in Group A than B at 1 (p<0.01) and 6 months (p<0.02). Among HC, IC, and MIS-C in Group A, comparable antibodies titers at 1 mo (S-RBD p=0.37, Parental NAbs p=0.38, Omicron NAbs p=0.83) and antibodies decay of 50-70% between 1 and 6 mo were observed. Similarly, an analogous decrement of antibodies was recorded among HC and IC in Group B (S-RBD p=0.60, Parental NAbs p=0.71, Omicron NAbs p=0.42) (Fig.2). ADDITIONAL KEY INFORMATION Author contact details: costanza.dichiara@phd.unipd.it Acknowledgements: | poster |
In the UK, approx. 25% of people registered with a GP are living with multimorbidity: having more than one long-term condition: e.g. diabetes, heart disease and dementia1. This is expected to become more common2. People from deprived backgrounds are worse affected, and more likely to have multiple conditions at younger ages1. Doctors and researchers are working to improve the health and care of people with multiple diseases. However, we also need to prevent people from developing multiple conditions. Many chronic diseases are partly caused by diet and how much we smoke, drink, and exercise. The societies we live in influence these ‘lifestyle choices’. Strategies to prevent long-term diseases can therefore focus on changing individual behaviour or the conditions around us. Background People with multiple conditions tend to have worse health, may have to take multiple medications, and often have many appointments with different doctors and nurses They are also more likely to have difficulties with mobility and daily activities, particularly in old age3. Multimorbidity is also a problem for the NHS, which is centred on care for specific individual diseases, making it hard to manage the care of patients with multiple conditions4. Estimating which strategies are most likely to stop people developing multiple conditions will help policy makers assess the different options. Predicting how many people may be living with multimorbidity in different scenarios can also inform the planning of services for future health and social care needs. Why is this topic important? Using data from 2004-2018 on 1m GP patients in England (from the Clinical Practice Research Datalink), we will estimate: • The number of people who are living with multiple conditions, and diagnosed each year • How diseases accumulate over the life-course: • How age, sex, and deprivation affect the above results What are the trends over time and how are different people affected? • There are many definitions of “multimorbidity”, e.g. having 2+ conditions lasting over 1 year, or including only certain diseases. Different definitions help to answer different questions, and healthcare workers and patients may have different priorities. • We aim to develop a definition of multimorbidity relevant for prevention, taking into account risk factors for disease and combining what is important for patients, healthcare workers, and the NHS. How should we define multimorbidity for prevention? • We will use a model (IMPACTNCD 5) to compare the effectiveness of different potential individual-level and structural prevention strategies. • A key component will be estimating which strategies are fairest to people living in the most deprived areas. • Examples strategies include structural policies on food e.g. marketing regulation or taxation; and individual level strategies e.g. NHS health checks and screening. What might help stop people developing multiple conditions? How can we reduce the future number of people living with more than one long-term health problem? Anna Head, Martin O’Flaherty, Kate Fleming, Chris Kypridemos Department of Public Health and Policy, University of Liverpool This project is funded by the University of Liverpool and supported by the National Institute for Health Research (NIHR) School for Public Health Research (Grant Reference Number PD-SPH-2015-10025). The views expressed are those of the author(s) and not necessarily those of the NIHR or the Department of Health and Social Care. Overall Aim: To look at whether and by how much we can stop people from developing multiple long-term conditions and what might be the best ways of doing this. Throughout, we will focus on whether and how people from more deprived areas of England have been or would be worse affected. We have 3 main research questions: Time to 2nd Time with multimorbidity Time to 1st disease Age Disease-free 1 disease 2 diseases 3+ REFERENCES: [1] Barnett et al. 2012. Epidemiology of multimorb | poster |
Canonicalized systematic nomenclature in chemoinformatics And some new canonicalization tools from OpenEye Jeremy J. Yang 3600 Cerrillos Road Suite 1107 Santa Fe, New Mexico 87507 505.473.7385 info@eyesopen.com www.eyesopen.com Introduction Canonicalization in chemoinformatics facilitates rigorous, unambiguous expression and handling of chemical data and knowledge. However, just as chemistry encompasses multiple levels of abstraction and modelling, no single canonicalization method is sufficient to solve all problems. This study reviews some existing canonicalization methodology and describes new methods implemented by chemoinformatics library OEChem and other OpenEye tools. Aha! -- Chemo-taxonomy is a “stranded hierarchy” The Morgan algorithm was a huge step forward, but the basic algorithm has some shortcomings, in performance and comprehensiveness, which have been corrected by subsequent investigators. The resulting methods have been implemented and widely used in large scale database systems. Some key contributions: • Morgan, 1965 à note to Harry: “You da man!” à CAS • Wipke & Dyott, 1974 à stereo-enhanced Morgan à MDL • Jochum & Gasteiger, 1977 à Morgan refinement à CACTVS • Shelley & Munk, 1977 à Morgan refinement • Weininger, 1988 à CANSMI canonical line notation à Daylight • Bradshaw, 1998 à parent compounds à GSK,Daylight • Delany & Sayle, 1999 à tautomers à OpenEye • INChi, 2004 à global canonical line notation Fig 2: Morgan slow due to symmetry. 1. Morgan, H. L., "Generation of a unique machine description for chemical structures - A technique developed at Chemical Abstracts Services", J. Chem. Doc. 1965, 5, 107. 2. Stereochemically unique naming algorithm, W. Todd Wipke, Thomas M. Dyott; J. Am. Chem. Soc.; 1974; 96(15); 4834-4842. 3. Canonical Numbering and Constitutional Symmetry, Clemens Jochum and Johann Gasteiger, J. Chem. Inf. Comput. Sci.; 1977; 17(2); 113-117. 4. Computer Perception of Topological Symmetry, Craig A. Shelley, Morton E. Munk; J. Chem. Inf. Comput. Sci.; 1977; 17(2); 110-113. 5. An Approach to the Assignment of Canonical Connection Tables and Topological Symmetry Perception, Craig A. Shelley, Morton E. Munk, J. Chem. Inf. Comput. Sci.; 1979; 19(4); 247-250. 6. David Weininger, Arthur Weininger and Joseph L. Weininger, "SMILES 2: Algorithm for Generation of Unique SMILES Notation", Journal of Chemical Information and Computer Science (JCICS), Vol. 29, No. 2, pp. 97-101, 1989. 7. A beginner's guide to responsible parenting or knowing your roots, www.daylight.com/meetings/emug98/Bradshaw/, EuroMUG '98, Cambridge, UK, Oct 1998. 8. Canonicalization and Enumeration of Tautomers, Jack Delany and Roger Sayle, www.daylight.com/meetings/emug99/Delany/taut_html/sld001.htm EuroMUG '99, Cambridge, UK, Oct 1999. 9. Hooked on Protonics, Roger Sayle and Geoff Skillman, www.eyesopen.com/about/events/presentations/acs02/sld001.htm, 224th ACS National Meeting, Boston, Aug 2002. 10. Introduction to Chemical Info Systems, John Bradshaw, www.daylight.com/meetings/emug02/Bradshaw/Training/, Euromug02 24th-26th September 2002, Cambridge UK 11. That INChIFeeling, www.reactivereports.com/40/40_3.html, Reactive Reports, Sep 2004 (issue 40) 12. OEChem, OpenEye Scientific Software, 2002. 13. QuacPac, OpenEye Scientific Software, 2004. References • subatomic à atoms à molecules • normal weight atoms à isotopes • Kekule molecule model à aromatic molecule models • non-stereo molecule à stereoisomers • single molecule à combinatorial libraries • single molecule à queries • small molecule à macromolecule + cofactors + ligands • single molecule à Markush structures • single molecule à tautomer set • single molecule à pKa states • single molecule à reactions • 2D à 3D There is a hierarchical relationship among some of these expansions while some are independent. For example, combinatorial library may involve stereoisomeric individuals or non-stereo. For every combination of molecular representations, ca | poster |
Center fo Innovativ CERTIFICATE OF A This certificate is presente Amel Beganovic For having successfully com "Summer Coding School 202 Blazor basics and applic Dragan Pepic Pr The course mentor Ce or Application of New a ve Technologies - NIT APPRECIATION ed to c mpleted training: 20" cations rof. dr Semsudin Plojovic enter NIT CEO CE DA DO and RTIFICATE ID:Blazor2020/1.9 ATE OF ISSUE: 20.10.2020. OI: 10.6084/m9.figshare.13125287 | poster |
Literature cited 1 Webster, M. S., Marra, P. P., Haig, S. M., Bensch, S. & Holmes, R. T. Links between worlds: unraveling migratory connectivity. Trends in Ecology & Evolution 17, 76–83 (2002). 2 Faaborg, J. et al. Long-term decline of a winter-resident bird community in Puerto Rico. Biodiversity and Conservation 22, 63–75 (2013). 3 Bouten, W., Baaij, E. W., Shamoun-Baranes, J. & Camphuysen, K. C. J. A flexible GPS tracking system for studying bird behaviour at multiple scales. J Ornithol 154, 571–580 (2012). 4 Ambrosini, R., Møller, A. P. & Saino, N. A quantitative measure of migratory connectivity. Journal of Theoretical Biology 257, 203–211 (2009). Acknowledgements & Funding We thank M. van den Tillaart and L. Meczarski of Lotek Wireless Inc. who provided technical support. This research was supported by grants from the Smithsonian Institution’s Competitive Grants Program for Science awarded to M.T.H and P.P.M, and the National Science Foundation. Miniaturized GPS Tags Identify Non-breeding Territories of a Small Breeding Migratory Songbird Michael T. Hallworth & Peter P. Marra Migratory Bird Center, Smithsonian Conservation Biology Institute, Washington, DC 20008 Migratory Connectivity Project - Introduction - Ovenbird with PinPoint-10 GPS tag Current knowledge of when and where migratory animals go throughout their annual cycle, i.e. migratory connectivity, is highly limited1. Yet this information is urgently needed given that many songbird species are exhibiting significant population declines2. Unfortunately, identifying locations of individuals during subsequent periods of the annual cycle, such as on the non- breeding grounds with high spatial resolution, has been only possible with large-bodied species (e.g., mammals, raptors, seabirds). Here, we tested and deployed a newly developed miniaturized tracking device that weighs ~1 g, combines archival technology with GPS accuracy (~10 m) and can be placed on small songbirds weighing <20 g. Until now, the smallest comparable device available was ~12 g and could only be placed on animals weighing at least 250 g3. Newly developed PinPoint-10 GPS tag which weighs ~1g and has ~10m accuracy Objectives 1) Identify non-breeding territories of Ovenbirds captured while breeding within two widely separated populations (~2000 km). 2) Characterize the environmental attributes of non-breeding territories using remote sensing. 3) Quantify the strength of migratory connectivity. - Methods - We deployed archival GPS tags on Ovenbirds (Seuirus aurocapilla) during the 2013 breeding season (May-June) at Hubbard Brook Experimental Forest, NH (n = 24) and Jug Bay Wetland Sanctuary in MD (n = 24). We attempted to re-capture the Ovenbirds the subsequent year to recover the GPS tags and download the data. The GPS tags were scheduled to take location information every 28 days from 1 July 2013 until 10 Mar 2014. Environmental Attributes Remote sensing was used to quantify the following non-breeding attributes: -Elevation (m) -Distance to coastline (km) -Vegetation cover (%) Migratory connectivity A Mantel test (rM) was used to determine the strength of migratory connectivity4. rM Values close to 1 indicate a strong correlation between breeding and non-breeding distance matrices (i.e., individuals breeding in close proximity also winter in close proximity). - Results - Non-breeding territory attributes Hubbard Brook Exp. Forest, NH n = 5 Jug Bay Wetland Sanctuary, MD n = 10 Difference (95 % CI) Elevation (m) 282.66 (195.68 : 367.88) 38.75 (16.33 : 45.47) 243.91 (154.61 : 332.13) Distance to Coastline (km) 17.27 (7.26 : 28.46) 24.40 (10.08 : 39.33) 7.13 (−10.94 : 24.70) High Vegetation Cover (%) 0.296 (0.08 : 0.56) 0.270 (0.13 : 0.41) 0.026 (−0.32 : 0.22) We recovered 15 GPS tags in 2014 (NH: n = 5, MD: n = 10). Ovenbirds breeding in New Hampshire wintered primarily on the island of Hispaniola, while birds breeding in Maryland wintered in Cuba and Florida (Fig. 1). Overall, Ovenbirds exhibited stron | poster |
POBREZA EXTREMA POLÍTICAS Y REPRESIÓN AYUDA HUMANITARIA RESTRICCIONES DE DERECHOS ¿QUÉ ESTÁ PASANDO? IMPORTANCIA DEL AUTOCUIDADO 97% de la población vive en la pobreza. La pobreza ha aumentado desde el 47% en 2020. Matrimonio precoz y venta de órganos como opcione s desesperadas. La ayuda no cubre las necesidades básicas. La congelación de reservas y el recorte d e ayuda s limita n la economía. En 2022, la ayuda fue mayorment e humanitaria , evitan do hambrunas. Libertad de expresión suprimida y medios de comunicación restringidos. Aumento de ejecuciones públicas y empeoramiento de la situación de minorías. Refugiados y desplazados enfrentan graves dificultades. SITUACIÓN DE LAS MUJERES Cierre del Ministerio de Asuntos de la Mujer y creación del Ministerio de Propagación de la Virtud. Nuevas leyes restrictivas y código de vestiment a para mujeres. Arrestos de mujeres que protestan por su s derechos. Los tribunales para investigar violencia d e géner o est án cerrados. Las mujeres que denuncian violenci a so n castigada s po r l as autoridades. VIOLENCIA DE GÉNERO NORMAS Y DECISIONES PROVIENEN DEL PROPIO INDIVIDUO LA OPRESIÓN Y VIOLENCIA LIMITAN LOS DERECHOS DE LAS MUJERES AFGANAS ESENCIAL PARA EJERCER DERECHOS Y TOMAR DECISIONES INFORMADAS DIFICULTADES ECONÓMICAS IMPIDEN EL EMPODERAMIENTO CAPACIDAD DE ACTUAR EN FUNCIÓN DE ASPIRACIONES Y DESEOS NECESIDAD DE FOMENTAR LA EDUCACIÓN Y CREAR ESPACIOS SEGUROS PARA LA EXPRESIÓN Y EL APRENDIZAJE DERECHOS HUMANOS EN AFGANISTÁN AUTONOMÍA DESAFIOS Afganistán enfrenta una crisis humanitaria y de derechos humanos severa, exacerbada por la pobreza extrema y el control talibán. EDUCACIÓN Y TRABAJO Prohibición de estudiar y trabaja r fuer a de l hoga r des de diciembre de 2022. Exclusión de la vida pública pone e n peligro la salud, vida y dignid ad de las mujeres. Estudiante de Trabajo de Fin de Grado: Carlos Loor Millán Tutora del Trabajo de Fin de Grado: Sonia Verdugo Castro | poster |
Abstract Behavioral science can be accelerated greatly by the use of digitally controlled devices capable of measuring relevant parameters and, if necessary, interact with the experiment. Those machines can be bought and they can do things in an implemented way. They are however neither cheap nor as adaptive as they should be. The focus of this poster is to demonstrate how to overcome the rather small barriers in order to develop their own machines. Recently, open hardware projects like the Arduino or the Raspberry Pi draw enormous community coding and building elements that can be fused together to fit the experimenters needs. We as scientists can benefit from large numbers of projects that are documented well in the internet, mostly by tutorial videos including component lists and code. Here we present a number of simple suggestions how to build yourself helpful devices for your behavioral and neurophysiological experiments. inputs: brightness color temperature ultrasonic sound magnetic field capacities moisture humidity contact liquids camera and a lot more... computing: Arduino (microcontroller) models: Uno, nano, mega ... - USB interface - 6 – 16 ADCs - easy to use Raspberry Pi (processor) models: 1, 2, 3, zero - +/- 1 GB RAM / 4x 1,2 GHz - OS (Linux) / GUI - LAN / WiFi / BT - on board - display output data analysis / storage: files, tables, matricies for: MS Excel, R, Statistica,... MatLab, SimuLink Python and a lot more... outputs: motors light sound display LAN WiFi Bluetooth RF serial/USB (PC) Memory (SD) and a lot more... Benjamin H Paffhausen, ben@paffhausen.org, Department of Neurobiology, Freie Universität Berlin, Germany Low cost open source hardware and software in behavioral and electrophysiological experiments: Arduino & Raspberry Pi The MIT License (MIT) Copyright (c) <year> <copyright holders> Permission is hereby granted, free of charge, to any person obtaining a copy of this software and associated documentation files (the "Software"), to deal in the Software without restriction, including without limitation the rights to use, copy, modify, merge, publish, distribute, sublicense, and/or sell copies of the Software, and to permit persons to whom the Software is furnished to do so, subject to the following conditions: The above copyright notice and this permission notice shall be included in all copies or substantial portions of the Software. THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE SOFTWARE. power supply: battery (5 – 24 V DC) powersocket (220 V AC) PC – USB (5 V DV) solar knowledge base: (find code and pinout) forum.arduino.cc stackexchange.com github.com learn.adafruit.com youtube.com communities: (ask questions) forum.arduino.cc raspberrypi.org/forums stackexchange.com github.com researchgate.net reddit.com availability: (where to buy) arduino.cc raspberry.org adafruit.com ebay.de conrad.de mouser.com necessary skills: - solid experience with searching the Internet for information - very basic understanding of physics and electronics - soldering (optional) what you will learn: - organize projects (develop from the glimmer of an idea to a device) - technical understanding of the possibilities and limits of devices that can support behavioral research. Be at the cutting edge! - using the swarm intelligence of the Internet how to start: - buy an Arduino - download Arduino IDE - connect Arduino via USB - open sketch blink - load it up to the Arduino - see the onboard LED blink - play with the code learn programming: (IMHO) The easiest way to learn programing is to start with a hardware based project. Analy | poster |
ПСИХОЛОГІЧНИЙ СТАН МЕДИЧНИЙ ПРАЦІВНИКІВ ПІД ЧАС ПАНДЕМІЇ COVID-19: МЕТА-АНАЛІЗ Мета: оцінити дані психологічного стану медичних працівників в умовах пандемії COVID-19 у порівнянні зі спеціалістами немедичних спеціальностей. Мета: оцінити дані психологічного стану медичних працівників в умовах пандемії COVID-19 у порівнянні зі спеціалістами немедичних спеціальностей. Матеріали та методи. Ми провели систематичний пошук у базі PubMed та Cochrane Library до 27 грудня 2021 року статей англійською мовою. Використовували таку стратегію пошуку: (((COVID-19) OR (SARS_COV-2)) AND ((((mental health) OR (stress)) OR (anxiety)) OR (depression))) AND ((((nurse) OR (physician)) OR (doctor)) OR (healthcare worker)). Мета-аналіз включав лише результати обсерваційних досліджень, опублікованих англійською мовою, які вивчали рівні тривожності, депресії та стресу за шкалою DASS-21 серед медичних і немедичних працівників, та не мали ризику систематичної похибки відповідно до Кокранівського положенння про написання систематичних оглядів втручання. Мета-аналіз проводили за допомогою методу фіксованих ефектів за допомогою Review Manager 5. Результати: Мета-аналіз включав 2 дослідження із загальною кількістю 912 респондентів, які відповідали необхідним критеріям. Згідно з мета-аналізом було виявлено, що в умовах пандемії COVID-19 у медичних працівників рівень стресу в порівнянні з немедичними спеціальностями підвищився майже в 1,5 рази (OR = 1,47, 95% ДІ 1,02-2,12, p =0,040). Рівень тривожності медичних працівників порівняно зі спеціалістами інших галузей і спеціальностей під час пандемії зріс у 2 рази (OR = 2,07, 95% ДІ 1,45-2,96, p<0,001). Рівень тривожності медичних працівників порівняно зі спеціалістами інших галузей і спеціальностей під час пандемії зріс у 2 рази (OR = 2,07, 95% ДІ 1,45-2,96, p<0,001). Згідно з вибраними дослідженнями, рівень депресії у медичних працівників суттєво не відрізнявся від рівня в інших галузях (OR = 1,02, 95% ДІ 0,69-1,50, p=0,920). Згідно з проведеним аналізом рівень депресії у медичних працівників суттєво не відрізнявся від рівня робітників в інших галузях (OR = 1,02, 95% ДІ 0,69-1,50, p=0,920). Висновки. Таким чином, в контексті пандемії COVID-19 медичні працівники більш схильні до стресу та тривоги, ніж ті, хто працює в інших галузях. Однак слід враховувати невелику кількість включених досліджень через значні вимоги до якості відібраних аналітичних досліджень, що може призвести до мінливості результатів. Полтавський державний медичний університет Кафедра психіатрії, наркології та медичної психології Мац О.В., Бойко Д.І. matsoksana040@gmail.com | poster |
Submm Galaxies: Signposts of Protoclusters (an on-going investigation…) Co-Is: Peter Capak (Caltech, USA), Andrew Blain (Leicester, UK), Kartik Sheth (NRAO/ NASA), Thiago S. Gonçalves (Valongo), Claudia Scarlata (U. Minnesota), A. Charbonnier (Valongo), S. C. Chapman (Dalhousie U.), I. Smail (Durham U.), R. Ivison (Edinburgh/ESO) Karín Menéndez-Delmestre Valongo Observatory (UFRJ, Rio de Janeiro) Target candidate overdensities at z~2-5 (HDF-N, ELAIS-N2, COSMOS) using LRIS/Keck, IMACS/Baade, LFC/ Palomar and GMOS/Gemini-N ① Identification of overdensity members: > 200 Ly-α emitters 411 - Bs 411 -g 16h-field Ly-α NB selection of Ly-α emitters + spec follow-up of continuum detected objects with photo-zs λ Ly-α 4.5 4.6 4.7 4.8 Redshift 0 2 4 6 8 10 Number Of Galaxies SMG SMG SMG QSO SMG Redshift COSMOS SMG at z~4.5 Redshift peaks around SMGs KMD in prep. | poster |
Exchange Exchange OPEN RESEARCH OPEN RESEARCH Sharing experiences of embedding Open Research practices at the University of Manchester 18th November 2020, 10am-12.30pm Register your place: https://bit.ly/3osxOpW @uomlibresearch #OR_Exchange | poster |
KIT – The Research University in the Helmholtz Association Motivation Extent and diversity of environmental data continuously increase due to more and new sensors with higher spatial and temporal resolution and due to the growth and automation of observational networks. These data form the basis for a better understanding of ecological systems either by data driven methods or by comparisons of data with model predictions. Still, a considerable amount of data are difficult to access or even stored on local data storage devices making it difficult or yet impossible to find, access and re-use it. In addition the data often lack a proper description (metadata) required for an interoperable analysis, hence they are barely useful for science. This results in very time consuming preparation and pre-processing of data, especially when datasets from different sources are combined. Steinbuch Centre for Computing (SCC), Institute of Water and River Basin Management (IWG) V-FOR-WaTer – a virtual research environment to access and process environmental data Marcus Strobl*, Elnaz Azmi, Sibylle K. Hassler, Mirko Mälicke, Jörg Meyer, Erwin Zehe *email address: marcus.strobl@kit.edu Objectives Quick and simple access to hydrological data and tools Quick pre-processing of data from diverse data sources Shared tools for reproducible data analysis Opportunity to easily upload data to established data repositories for publication Centralize hydrological data from universities and state offices for a coordinated long-term monitoring Security layer to ensure that users can access only data for which they have access rights Tools Geostatistics and analysis tools integrated as Web Processing Services, WPS (see scikit-gstat in Software). Based on the standalone python toolbox hydrobox (see Software) Results will come with references to enable users to cite data owners appropriately Graphical workflow tool will be integrated Data Extensive metadata model to ensure usability of stored datasets Initial data in the portal come from the KIT Hydrology group (IWG) and LUBW (Landesanstalt für Umwelt, Baden-Württemberg) Development and testing of the portal is based on datasets from the CAOS research unit (Catchments as organised systems) Extensible database for user data and interface to open data repositories Website: http://www.vforwater.de/ Stay tuned! Fig. 2: Preliminary graphs from WPS toolbox for variogram analysis (left) and flow duration curves (right). Fig. 3: Screenshots of map with clusters of data with similar sample location (left), data preview (upper right) and metadata preview (lower right). Fig. 1: Screenshots of V-FOR-WaTer web portal (upper part) and detail with the active ‘filter on map’ drawing tool. Portal Login via B2ACCESS Filter menu to select data Map tools Tools for hydrological analyses Tools and data available through web portal and interfaces for common computing environments (Matlab, Python and R) Data export (cvs, shapefile) Metadata export (XML, ISO19115) Software vforwater-portal: Portal of the virtual research environment https://github.com/VForWaTer/vforwater-portal pleasant: Django based skeleton of a web portal application with maps https://github.com/VForWaTer/pleasant hydrobox: hydroligical preprosessing and analysis toolbox https://github.com/mmaelicke/hydrobox scikit-gstat: geostatistics tools https://github.com/mmaelicke/scikit-gstat Dieses Poster steht unter der Lizenz Creative Commons Namensnennung 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/legalcode | poster |
Juliana García-Mejía, David Charbonneau, Dan Fabricant, Jonathan Irwin, Robert Fata, Joseph Zajac, Brian McLeod, Peter Doherty, Ryan Cloutier Tierras the Observatory First Light Results from a New Ultra- precise Time-series M-dwarf Photometer For more information, contact: juliana.garcia-mejia@cfa.harvard.edu State-of-the-art ground-based robotic facilities studying mid-to-late M dwarfs and their planets typically reach per-point night-to-night photometric precisions in the order of 3000 ppm. These experiments are limited by precipitable water vapor (PWV) error, since water features in the photometric bandpass result in a color dependent offset when comparing the relative brightness of the red target to the blue field stars. We have refashioned the 1.3-m 2MASS N telescope located at the F.L. Whipple Observatory atop Mount Hopkins, Arizona, into an ultra-precise time-series photometer. The Tierras Observatory is designed to (1) limit systematic errors, notably PWV error, to <250 ppm across an observing season and (2) limit stochastic errors, notably scintillation and target photon noise, to less than that of an Earth-transit for a 5 min integration time, for all stars with radii <0.3 R⊙ out to a distance of 15 pc. For more information, please refer to Garcia-Mejia et al. Proc. of the SPIE, 114457R, arXiv:2012.09744, (2020). Science Operations Have Begun! A Representative First-Light Tierras Light Curve Secondary Baffle 1 3 820 830 840 850 860 870 880 890 900 910 Wavelength (nm) 0 20 40 60 80 100 Transmission (%) Tellurics, 5mm Filter (Empirical) A four-lens focal reducer and field-flattener under the 1.3-m primary mirror (M1), which increases the field of view from a to a side and allows us to monitor more comparison stars. 0.19∘ 0.50∘ A custom narrow (40.2 nm FWHM) bandpass filter centered at 863.5 nm (right plot) avoids prominent telluric features and desensitizes our o b s e r v a t i o n s f r o m changes in PWV. 400 600 800 1000 Wavelength (nm) 0.0 0.2 0.4 0.6 0.8 Quantum E±ciency Tierras CCD MEarth CCD Summer 2021: Installed the Tierras filter, optics, and CCD dewar under M1 (top left). Fall 2021: Tested the remote control software on- s k y , c o l l i m a t e d t h e telescope, and reached first light! Winter 2021-2022: Built and installed a new set of baffles to minimize sky background (bottom right). On the left, we show a schematic diagram of the optics, along with representative ray traces and spot diagrams. Plate scale = 0.43’’/pixel. 2 A deep- d e p l e t i o n C C D operating in fast f r a m e t r a n s f e r (shutter-less) mode with>85% quantum efficiency (QE) in our bandpass (right plot), low read-noise and low dark current. A custom dewar houses the CCD, maintaining it at -105℃. 4K × 4K Commissioning Summary CCD Dewar Mount Plate Optics Installation Fixture Mount Surface Filter mounted to its bezel CCD chip with masked readout regions Primary Baffle Primary Mirror LHS 2913 - M3 star 13 pc away. This light curve (left) is not de-trended, highlighting the efficacy of our filter. We are already meeting our photometric precision goals on this star (right). Project Overview LHS 2913 The design choices enabling our photometric precision goals include: | poster |
Innovative Research for a Sustainable Future www.epa.gov/research Fidelity: 20.7% of papers with complete documentation had an accurate, fully described mathematical basis. The most commonly observed error was inconsistent units within the model equations (35.3% were erroneous, and 34.5% of the rest were ambiguous). A Method to Quantify Reproducibility in PBPK Model Methods and Results Risa R. Sayre1,2, R. Woodrow Setzer1, John Wambaugh1, Christopher M. Grulke1 1: U.S. Environmental Protection Agency, Office of Research and Development, National Center for Computational Toxicology 2: Oak Ridge Associated Universities Risa Sayre l ORCiD 0000-0002-6173-8020 l sayre.risa@epa.gov l 919-541-4871 4. Conclusions & Discussion 5. References Physiologically-based pharmacokinetic (PBPK) modeling describes how the amount of an exogenous chemical in the body changes over time, using values specific to properties of that chemical in a system of equations representing relevant biological processes. (1) National Research Council, Committee on Toxicity Testing and Assessment of Environmental Agents, Board of Environmental Studies and Toxicology, Institute for Laboratory Animal Research, Toxicity Testing in the 21st Century. A Vision and a Strategy , 2007a Washington, DC National Academies Press (2) U.S. Environmental Protection Agency (EPA). (2006) Approaches for the Application of Physiologically Based Pharmacokinetic (PBPK) Models and Supporting Data in Risk Assessment. National Center for Environmental Assessment, Washington, DC; EPA/600/R-05/043F. (3) McLanahan, E. D., El-Masri, H. A., Sweeney, L. M., Kopylev, L. Y., Clewell, H. J., Wambaugh, J. F., Schlosser, P. M. (2012). Physiologically Based Pharmacokinetic Model Use in Risk Assessment - Why Being Published Is Not Enough, Toxicological Sciences, 126(1), 5-15. (4) Barton, H. A., Chiu, W. A., Setzer, R. W., Andersen, M. E., Bailer, A. J., Bois, F. Y., DeWoskin, R. S., Hays, S., Johanson, G., Jones, N., Loizou, G., MacPhail, R. C., Portier, C. J., Spendiff, M. Tan, Y. (2007) Characterizing Uncertainty and Variability in Physiologically Based Pharmacokinetic Models: State of the Science and Needs for Research and Implementation, Toxicological Sciences, 99 (2), 395-402. (5) International Programme on Chemical Safety. Characterization and application of physiologically based pharmacokinetic models in risk assessment. (IPCS harmonization project document; no. 9). WHO 2010. (6) Clark, L. H., Setzer, R. W., & Barton, H. A. (2004). Framework for evaluation of physiologically- based pharmacokinetic models for use in safety or risk assessment. Risk Analysis, 24(6), 1697–1717. (7) Pearce, R., Setzer, R., Strope, C., Sipes, N., & Wambaugh, J. (2017). httk: R Package for High-Throughput Toxicokinetics. Journal of Statistical Software, 79(4), 1-26. (8) MacLeod, M., Scheringer, M., McKone, T. E., & Hungerbuhler, K. (2010). The State of Multimedia Mass-Balance Modeling in Environmental Science and Decision-Making. Environmental Science & Technology 44 (22), 8360-8364 | Figures implemented in Python 3.5 using matplotlib_venn | Analysis conducted using Python 3.5, R 3.3.2, MATLAB R2015a Fig 1. Basic inhalation PBPK model system, showing model compartments and flows (figure from IPSC5) toxicity testing dose-response (PBPK) modeling human exposure data risk contexts Models describe a system by synthesizing knowledge and assumptions into a quantitative expression, so context matters8. While building an open PBPK model database for risk assessors and modelers from 973 publications, we wanted to effectively capture complete parameterization for all models. We developed a list of criteria to systematically quantify common, fundamental obstacles to reproduction of methods and results for this set. Fig 2. Equation example (figure from McLanahan et al.3). A concentration flows into a compartment at a rate determined by blood flow. The concentration flowing out is reduced by the amount that partitions into the tiss | poster |
To: Ms. Louise Chamberlain Resident Representative UNDP Kyrgyzstan To: Ms. Louise Chamberlain, Resident Representative UNDP Kyrgyzstan From: Ms. Aizhan Ussenaliyeva International Scientist and Researcher ( ORCID #0000-0002-7084-8352 ) Founder and CEO of Save Lake Balkhash International Research Project Dear Ms. Louise Chamberlain, I am an international female scientist and researcher, currently leading a scientific research dedicated to clean water preservation and multi-sectoral knowledge creation, transfer and exchange between heavy industrial technologies and climate change innovative solutions. As a founder and CEO of the first water data open research I represent millions of women across the globe who strive to find reasonable solutions to the most critical social threats, such as lack of access to clean water and sanitation, poverty, gender discrimination and climate change. There are 7 Global Sustainability Development Goals that my project corresponds to: SDG5 – Achieve gender equality and empower all women and girls, SDG6 - Clean water and sanitation SDG 11 - Sustainable cities and communities, SDG 12 - Responsible consumption and production, SDG 13 - Climate Action, SDG 14 - Life below water and SDG15 - Life on land. The DNA of my research is based on holistic relationships between nature and people and is programmed to create an ecological data to facilitate communication between academia, corporate world, governmental entities and public sector. My work was published in Science Magazine and recently I got invited to join the 6th International Conference on Environmental Sustainability and Climate Change as a speaker in Philadelphia, USA in August 21-22, 2023. I create an intersection between lakes reproductive cycle and energy security and my work benefits socio-economic development of Central Asian region. I created a free access open data library to share my knowledge for the benefit of global community and educated 50,000 people from 18 countries: https://figshare.com/authors/Aizhan_Ussenaliyeva/12049805 https://orcid.org/0000-0002-7084-8352 I am asking to support my independent scientific research by sponsoring my trip to the above mentioned international climate change conference and a website launch to educate more people across the globe. This will help to promote female-led scientific projects and climate change initiatives in Kyrgyzstan, where I reside and continuously work on my research. Sincerely, Ms.Aizhan Ussenaliyeva 03.06.2023 Save Lake Balkhash International Research Project Osmonkula 128, Office #4 Bishkek, Kyrgyzstan Tel.: +996508558511 Email: savelakebalkhash@gmail.com | poster |
Affilliations: 1University of Exeter; 2Durham University References: [1]: Goluskin, D. et al., ‘Convectively Driven Shear and Decreased Heat Flux’. Journal of Fluid Mechanics 759 (1 November 2014): 360–85 [2]: Burns, K. J. et al., , "Dedalus: A Flexible Framework for Numerical Simulations with Spectral Methods," Physical Review Research 2 (23 April 2020): 023068 [3]: Orvedahl, R. et al., ‘Prandtl-number Effects in High-Rayleigh-number Spherical Convection’. ApJ 856 (20 March 2018): 13 [4]: Currie, L. et al., ‘Convection with misaligned gravity and rotation: simulations and rotating mixing length theory’. MNRAS 493 (10 February 2020): 5233-5256 [5]: Brown, B. P. et al., ‘Rapidly Rotating Suns and Active Nests of Convection’. ApJ 689 (20 December 2008): 1354-1372 Implications Sun Ra ≈ 1020 Pr ≈ 10-7 [3] - Astrophysical values for Ra and Pr are inaccessible to direct numerical simulations - Mixing Length theory is widely employed in astrophysics to model convection (e.g. [4]) but assumes a particular 𝑁𝑢(Ra) relationship and does not take shear into account - If realised in a star, shear would likely effect the entropy gradient and other aspects of interior convection So, can stars shear? 3D isotropic convection does not appear to establish shearing states. However… - Rotation and magnetism can make convection more anisotropic, forcing quasi-2D behaviour in nature (e.g. [5]) - These cases may allow for ‘bursts’ of shear damping vertical transport as described here. We intend to investigate the 3D, rapidly rotating equivalents of these states in future work Fig 2: Temperature snapshots from numerical simulations showing “normal” convection (left) and ”shearing” (right) Fig 1: A schematic comparing “normal” convection and “shearing” convection All stars transport heat by convection and the efficiency of this transport is affected by (among other things) shear flows 2-D Rayleigh-Bénard convection has been observed to drive horizontal ‘shearing’ flows These flows are characterised by very little vertical convective energy transport These flows can be reproduced in numerical simulations, and have been explored for Prandtl number greater than unity [1] We present numerical simulations of Rayleigh-Bénard convection for Prandtl numbers less than 1, to better approximate the astrophysical environment What is Shearing Convection? Fig 3: Comparisons of diagnostic quantities for Pr=0.1 (left) and Pr=0.01 (right). A triangle represents a shearing case, and a circle is a non-shearing case Results Shearing states are readily established in low Pr convection The Pr=0.1 cases make it clear that shearing cases are described by a different 𝑁𝑢Ra relationship that non-shearing cases The vertical heat transport is radically altered by the presence of strong shear The Dedalus pseudo-spectral code [2] was used with periodic boundary conditions to simulate a range of parameters (left) for one viscous time Table 1: The simulated parameters. A tick represents cases with shearing flows. The shaded boxes were not simulated Rayleigh number (Ra) is a measure of flow buoyancy – higher means more convective driving Prandtl number (Pr) is the ratio of viscosity to thermal diffusivity Nusselt number (𝑁𝑢) is the time-averaged ratio of convective to conductive flux at a boundary - 𝑁𝑢=1 corresponds to pure conduction; the larger the value of 𝑁𝑢the more vigorous the convection Dimensionless Definitions Our Simulations Fig 3: Instantaneous Nusselt Number 𝑁𝑢(𝑡) for a non-shearing (left) and a shearing (right) case An Investigation Into Convectively Driven Shear At Low Prandtl Number Tom Joshi-Cale1 Matthew Browning1 | Simon Lance1 | Laura Currie 1,2 tj294@Exeter.ac.uk TomJoshiCale Pr \ Ra 1e4 5e4 1e5 3e5 5e5 1e6 0.1 0.01 | poster |
Christian Gutsche on behalf of the ATLAS Liquid Argon Calorimeter group Institute of Nuclear and Particle Physics, TU Dresden, Germany Machine Learning for Real-Time Processing of ATLAS Liquid Argon Calorimeter Signals with FPGAs DIS2022: XXIX International Workshop on Deep-Inelastic Scattering and Related Subjects • Sampling calorimeters for the measurement of energy deposited by electrons, photons and hadronic jets • 182 000 cells filled with Liquid Argon as medium for ionization • Resulting triangular pulse is amplified, shaped and digitized at 40 MHz • Energy reconstruction with Optimal Filter (OF): linear combination of up to 5 samples 2. Phase II Readout Electronics Upgrade ●High Luminosity LHC (HL-LHC) planned to start in 2029 with up to 7.5 times nominal luminosity ●About 140 proton-proton-collisions per bunch crossing ●Challenges for LAr calorimeter readout under HL-LHC conditions: ●Revised trigger scheme allows selection of events at 1 MHz and in subsequent bunch crossings (BC) ●Number of events with overlapping signals will increase → in-time and out-of-time pile-up ●New Liquid Argon Signal Processor (LASP) boards will be installed during Long Shutdown 3 (LS3, Phase-II upgrade): ●FPGA to implement more complex real-time energy reconstruction algorithms ●Maximum latency of ~150 ns required by trigger ●Up to 512 detector cells processed on one FPGA ●Readout chain can be simulated with AREUS software: ●Supports electronics noise, digitization and LHC bunch train structure ●Generates digitized pulse sequence as expected from specific detector cell 3.1 Convolutional Neural Networks (CNN) ●Machine Learning solutions under investigation to replace OF in future HL-LHC conditions ●Pulse tagging sub-network (2 layers) ●Sigmoid activation function ●Energy reconstruction sub-network (1-2 layers) ●Uses results of tagging sub-network and raw ADC samples ●ReLU activation function ●Trained and evaluated on AREUS samples ●Training in two stages: 1. Tagging part only as pre-training 2. All layers together for energy reconstruction 0 5 10 15 20 25 30 35 40 BC 1 − 0 1 2 3 4 5 [GeV] T E True energy Digitized signal AREUSSimulation ) = (0.5125, 0.0125) φ , η EMB Middle ( > = 140 µ < 0 1 2 3 4 5 [GeV] T E BC #6 BC #7 BC #8 BC #9 BC #10 RNN ADC(6) RNN ADC(7) ... RNN ADC(10) 0 Dense ET(7) 0 1 2 3 4 5 [GeV] T E BC #7 BC #8 BC #9 BC #10 BC #11 RNN ADC(7) RNN ADC(8) ... RNN ADC(11) 0 Dense ET(8) 0 1 2 3 4 5 [GeV] T E BC #8 BC #9 BC #10 BC #11 BC #12 RNN ADC(8) RNN ADC(9) ... RNN ADC(12) 0 Dense ET (9) 3.2 Recurrent Neural Networks (RNN) RNN cell ADC(n) Dense ET (n − 4) RNN cell ADC(n + 1) Dense ET (n − 3) RNN cell ADC(n + 4) Dense ET (n) RNN cell ADC(n + 5) Dense ET (n + 1) ... ... ... ●RNNs have connections between nodes over time → memory ●Long Short-Term Memory (LSTM) well suited for long sequences due to gated design ●Limited number of internal dimensions and only one layer due to FPGA resource constraints ●Single dense neuron as decoder to reconstruct energy from LSTM output ●Single-cell LSTM (above) ●Operates sample per sample on entire sequence ●Expected to be more robust for overlapping pulses ●Sliding-window LSTM (right) ●Newly instantiated LSTM operates on fixed number of past samples at each BC ●Expected to be more robust for isolated pulses ●Vanilla RNN: simple structure to reconstruct energy and forward information 3.3 Performance in Simulation ●CNNs and RNNs outperform OF in both mean and bias behaviour ●CNNs/RNNs show less biased behaviour with overlapping pulses Figures: difference between predicted and true energy over the temporal gap between two higher energy deposits for OF (right) and and different types of artificial neural networks (ANN) (bottom) 4. FPGA Implementation and Performance ●CNN: Direct implementation in VHDL ●Optimal use of DSP resources on FPGA ●Architecture automatically configured from files obtained during training ●RNN: High Level Synthesis approach ●Easier design and more flexibility in architecture ●Go | poster |
IT IS NOT THAT FUNNY. CRITICAL ANALYSIS OF RACIAL IDEOLOGIES EMBEDDED IN RACIALIZED HUMOUR DISCOURSES ON FACEBOOK IN BRAZIL ABSTRACT ANATOMY OF RACISM ON FACEBOOK PRELIMINARY FINDINGS IN SUMMARY This study explores the use of Facebook as a powerful mechanism enabling individuals to disseminate and reinforce racialized discourses and negative representations of black individuals in Brazil, particularly concealed in disparagement humour posts and their associated comments. For this purpose, the study applies Critical Discourse Analysis as research method to unveil the embedded racialized and discriminatory discourses. There are five important dimensions to understand the full reach of the ideological racist discourses embedded on Facebook: 1) the target of the online racism; 2) the names of the Facebook communities where those content circulate; 3) the reverberation capacity of the posts published; 4) the actual comments; and 5) the profile of the individuals who engage in this behaviour and their inner motivations for doing so. Preliminary fieldwork results have revealed the following aspects: a) almost 80% of the victims of online mockery are predominantly middle-class, well-educated black women aged between 20 to 38 years; b) oftentimes the derogatory posts employ rude and impolite language to talk about black individuals; c) many users of Facebook communities displaying derogatory content express their endorsement to the content with laugher and jeer; d) there are evidence indicating a considerable degree of reverberation capacity of the derogatory comments given that they can potentially engage users for months and even for a couple of years after the original publication; and e) black women are at the forefront of the initiatives to challenge those derogating practices. It can be inferred that the underlying discourse embedded in the posts displayed on Facebook convey that being black in Brazil is associated with engagement to low qualified jobs, that is expected that they do not hold an university degree or any schooling at all, they are prone to be involved with illegal activities, they predominantly live in favelas and that their social place is at the lower social strata and there is the place where they should stay. On top of that, it is also considered that Facebook as a social media platform, enables individuals to convey their racist and discriminatory ideologies in such a way that it was not possible before, and due to social convention constraints, the sort of derogatory comments displayed online is not usually expressed in ordinary face-to-face interactions. Finally, the reverberation of the posts strongly contributes to the reinforcement of the disparagement discourse given that they keep engaging people for a long period of time in this conversation like an echo in cyberspace. Image: Shutterstock 2017 Luiz Valério de Paula Trindade | PhD candidate in Sociology Supervisors: Dr Bindi Shah | Dr Laura Lewis | Dr Charlie Walker | poster |
Simultaneous NuSTAR – XMM-Newton observations of AGN Abstract Joint X-ray observations of the satellites XMM-Newton and NuSTAR have become the main tool to study the 6.4 keV iron K alpha line emission in the direct environment of black holes. The soft (XMM-Newton) and hard (NuSTAR) X-ray spectra together allow determining the continuum, absorption, reflection and emission lines. In order to get better results in future, the present study aims to help improving the cross-calibration by analyzing all publicly available simultaneous NuSTAR – XMM-Newton observations in a coherent way. Andrea Gokus1,2, Norbert Schartel2, Maria Santos-Lleo2, Jörn Wilms1, Thomas Dauser1, Felix Fürst3, Ralf Ballhausen1 XMM-Newton Artist's impression of XMM-Newton ©ESA Launched in 1999, ESA's XMM-Newton observes the energy range from 0.2 to 12 keV with the European Photon Imaging Camera (EPIC) using a Wolter type I telescope. Additionally it has an Optical Monitor (OM) and a Reflection Grating Spectrometer (RGS) onboard. NuSTAR NuSTAR, launched by NASA in 2012, is the first focusing high-energy instrument in space. It uses Wolter type I approximation optics and two semiconductor detectors (FPMA, FPMB) to observe hard X-rays from 3 to 79 keV. The 10 m long mast was deployed in space. Artist's impression of NuSTAR ©NASA 1Dr. Karl Remeis Observatory & Erlangen Centre for Astroparticle Physics (ECAP), Universität Erlangen-Nürnberg, Sternwartstraße 7, 96049 Bamberg, Germany 2European Space Astronomy Center (ESAC), ESA, 28692 Villanueva de la Cañada, Madrid, Spain 3Cahill Center for Astronomy and Astrophysics, California Institute of Technology, Pasadena, CA 91125, USA Why simultaneous observations? Performing observations with XMM- Newton and NuSTAR together has the main advantage that they have an energy overlap between 3 and 12 keV, which includes the region of the iron K alpha line. The emission features around 6.4 keV allow the analysis of relativistic line broadening near black hole systems, when the underlying continuum is well known. This can be achieved with a simultaneous obser- vation by both satellites, since their effective areas overlap from 3 to 12 keV. Comparison of the effective area of the XMM-Newton satellite (black) and the NuSTAR satellite (red). Comparison of XMM-Newton and NuSTAR data Ideally, with a perfect calibration, a model for a certain X-ray spectrum should give the same results when applied to both XMM-Newton and NuSTAR data. Since the perfect calibration is not possible to achieve, calibration uncertainties make discrepancies appear in the data analysis and the determination of astrophysical values is impacted. Those discrepancies can be shown, e.g. by fitting a model to an XMM- Newton spectrum and then comparing the strictly simultaneous NuSTAR spectrum with this model (see ratio plots below; black: XMM-Newton EPIC PN data, red: NuSTAR FPMA data, green: NuSTAR FPMB data; the data has been binned for clarity). The used models contain a powerlaw and the X-ray absorption model tbnew (Wilms et al., 2000; http://pulsar.sternwarte.uni-erlangen.de/wilms/research/tbabs/). If the source shows relativistic reflections effects, the reflection model relxill (Dauser & Garcia et al., 2014) is included as well. Ark 120 Seyfert 1 galaxy z = 0.0327 3C 273 Blazar z = 0.158 MCG-6-30-15 Seyfert 1 galaxy z = 0.008 Swift J2127.4+5654 Narrow-Line Seyfert 1 Galaxy z = 0.0144 3C 120 Broad-Line Radio Galaxy z = 0.0336 ΔΓ EPN-FPMA 0.135 ± 0.004 EPN-FPMB 0.128 ± 0.007 Results & Conclusions A difference between the photon indices for data from both satellites can be found when fitting the spectra from 3 to 10 keV simultaneously. This has been done with a sub-sample of 12 observations of 6 AGN. The difference can be plotted over the flux of the different sources in order to show that ΔΓ is independent of the flux and therefore not due to pile-up. The mean differences for EPN-FPMA and EPN-FPMB are: These preliminary results show a potential cross-calibrati | poster |
Forschungsdaten am Max-Planck-Institut für Evolutionsbiologie Carsten Fortmann–Grote, Beate Gericke, Iben Martinsen, Kristian Ullrich, Derk Wachsmuth Digitale Woche Kiel, 15. Mai 2024 Grundsätze Daten Management Plan zu Beginn eines Projekts Alle Rohdaten sind in internen Datenbanken hinterlegt und dokumentiert (OpenBIS, OMERO, GitLab) Rohdaten und Quellcode for publizierte Resultate in offenen Repositorien hinterlegt Datenquellen (C) Zeiss Bilddaten Mikroscopie CT, Röntgen Kameras (C) Illumina Sequenzdaten Intern Extern (C) IBM Simulationen Onsite Offsite Schema Data collection Data analysis DMP Sequence data Materials Notes Protocols Simulation data Image data Code OMERO Storage openBIS GitLab/Hub DMP FDK DMP Library FDK edmond zenodo ENA BIA GitLab/Hub PuRe Results Publication Library Reuse Checklist DMP=Daten Management Plan FDK=Forschungsdatenkoordinator Repositorien Doku Intern Öffentlich Sequenzen OpenBISSeq. ArchivSRA, ENA MikroskopieOMERO OMERO BioimageArchive Code GitLab GitLab Github, Edmond Elektronisches Laborbuch und Labor-Informations-Management System OpenBIS ETH Zürich Laborbuch Bakterienstämme Formblatt Z Sequenzieraufträge Mikroskopie Datenbank OMERO Daten per GUI importieren Key-Value Annotationen Webform Spreadsheet Kontrollierten Vokabularien Copyright: Max-Planck-Gesellschaft (2024) | poster |
ARMA Research Office Survey 2020 | Benchmarking UK Institutional Research Offices Report and infographics prepared for ARMA by Research Consulting Limited. University of Nottingham Innovation Park, NG7 2TU, UK | www.research-consulting.com Research Consulting Limited is a Company Registered in England and Wales Reg No. 8376797 This work is licensed under a Creative Commons Attribution 4.0 International License. Most likely to be in the research office remit Distribution of research office staff by functional areas Support for REF Research Policy & Strategy Research governance, ethics and integrity Pre-award & costing Research systems and MI Least likely to be consistently in the research office remit Scholarly comms, outputs and bibliometrics Public engagement Post-award management Doctoral Schools and PGR support Research finance A major survey of directors of UK research offices: structures, staffing and trends One third of UK universities responded to the survey through Directors of Research. Responses considered 19 functional areas that can fall within the research office remit and job functions, covering over 2,000 reported FTEs. ARMA Research Office Survey 2020 74% report absorbing activities into the existing team / roles 30% report hiring temporary staff 22% report that staff in other areas are seconded to REF-related roles Remit and functional areas How do research offices handle additional resourcing needs associated with the REF preparation and submission process? Managing the Research Excellence Framework Functional areas Other Research Policy & Strategy Systems and MI Support for REF Research impact Governance, ethics & integrity Executive & admin support Research finance Post-award Pre-award & costing Business development Doctoral School/PGRs & researcher dev Research contracts % of FTEs from 2,011 total 4 % 4 % 4 % 5 % 5 % 6 % 7 % 7 % 9 % 9 % 9 % 1 5 % 1 6 % | poster |
MD pharmacophore-based search for novel MARK4 inhibitors: in silico and in vitro studies Alina Kutlushina, Olena Mokshyna, Lenka Hruba, Sona Gurska, Marian Hajduch, Petr Dzubak, Pavel Polishchuk Institute of Molecular and Translational Medicine, Palacký University and University Hospital in Olomouc, Olomouc, Czech Republic alina.kutlushina@upol.cz This work was supported by the INTER-EXCELLENCE LTARF18013 project (MEYS), the European Regional Development Fund - Project ENOCH (No. CZ.02.1.01/0.0/0.0/16_019/0000868) and ELIXIR CZ research infrastructure project (MEYS Grant No: LM2018131). MD snapshot timeline MD pharmacophores 3D pharmacophore hashes MD representative pharmacophores Materials and Methods Hit1 MARK1 MARK2 MARK3 MARK4 IC50, μM >50 14.72 0.0088 0.032 Hit2 MARK1 MARK2 MARK3 MARK4 IC50, μM >50 19.79 >50 12.01 Results Summary We developed and validated a workflow for virtual screening based on our previous implementation of MD pharmacophores and molecular docking. We were able to find a novel MARK inhibitor which was selective over 1 and 2 subtypes of MARK family and can be promising for further research. github.com/ci-lab-cz/pharmd A B D F G 1 2 3 4 5 compound conformers 4 5 = 0.8 CCA score RTB <= 5 MW <= 500 Da MD snapshot timeline 150 ns 5965 5221 4015 2532 MD representative pharmacophores 3938 2331 4989 5876 5+ features MD representative pharmacophores MD pharmacophore virtual screening 68337 molecules 3.8 % up to 50 conformers Conformers coverage Approach (CCA) 618 molecules 0.035 % Molecular Docking 235 molecules 0.013 % Visual inspection of the docked poses 24 hits 1783794 molecules 100 % The complexes of MARK4 with the 4 initial inhibitors MARK1, μM MARk2, μM MARK3, μM MARK4, μM >50 >50 >50 0.95 >50 >50 38.8 0.59 >50 >50 >50 0.47 >50 >50 >50 1.29 CCA score is the number of conformers which were mapped by at least one pharmacophore from the representative set divided by the total number of conformers. A B C D E F G b36..87 53b..ef 53b..ef e4f..ce 53b..ef 4af..f3 79f..31 MARK4 protein is a Serine/Threonine protein kinase, structurally related too the AMPK/Snf1 subfamily of the CaMK group of kinases. MARK4 proteins’ abnormal function has been associated with several pathological conditions including Alzheimer’s disease, which makes it a promising target for drug development. In the current study we searched for selective MARK4 inhibitors of new chemotypes too extend structural diversity of compounds for further selection and optimization . For this purpose, we used the workflow based on molecular dynamics (MD) pharmacophores. This approach allows us too take intoo account the conformational flexibility of the protein, while a pharmacophore is an abstract representation of the molecular interactions of the ligand with the protein, which is not related too the specific compound structure. Introduction 5RC MARK1 MARK2 MARK3 MARK4 IC50, μM 0.0041 0.0025 0.0039 0.0046 The MARK4 crystal structure exists in complex with a pyrazolopyrimidine (PDB ID: 5es1). The inhibitor (5RC) is highly active too MARK4 but not specific. Correlation of CCA and docking scores Distribution of the docking scores up to 50 conformers ChEMBL + proprietary 90 inactive and 29 active Virtual screening on validation set Quality assessment of MD representative pharmacophores PharMD MD pharmacophore virtual screening 68337 molecules 3.8 % up to 50 conformers Conformers coverage Approach (CCA) 618 molecules 0.035 % Molecular Docking 235 molecules 0.013 % Visual inspection of the docked poses 24 hits 1783794 molecules 100 % AutoDock Vina ChEMBL Proprietary Found hit Database Molecular space visualization of known MARK4 inhibitors (t-SNE) Tanimotoo 0.202 The nearest structure 0.205 White structures are poses determined by pharmacophores Pink structures are docked poses by AutoDock Vina -8.6 -8.1 -7.6 -8.8 -9.4 Docking score Proprietary reference compounds 0.03 The most distantMol 2Mol 3 | poster |
#SuperPV @SUPERPV_H2020 Intermediate SUPER PV project results have been already achieved in WP3, which is focusingon the development and demonstrationof the following PV module innovations: • low cost and easyto apply multifunctional nano-coatingswith antisoiling and antireflectiveproperties in one layer. • light managementin bifacialc-Si modules to increasethe power output up to 7 Wp. • laminateddiode innovations produced by solarcell production • low-cost encapsulation innovation with a low-cost humidity barrierleading to 45% cost reduction of flexible CIGSmodules • inline inspection system of encapsulation process for CIGS modules • recyclingapproaches and their demonstration to alltypes of modules under consideration in SuperPV project • Cost and performanceevaluation (Eur/Wp, Eur/kWh). Julius Denafas, „Soli Tek R&D“ UAB SUPER PV PROJECT – SUPPORT COST-REDUCTION OF THE PV SYSTEM THROUGH INNOVATIVE TECHNOLOGIES ON PV MODULE LEVEL This project has received findings from the European Union’s Horizon 2020 research and innovation programme under grant agreement N° 792245. The sole responsibility for the content of this material lies with the authors. It does not necessarily reflect the opinion of the European Union. Neither INEA nor the European Commission are responsible for any use that may be made of the information contained therein. www.superpv.eu Find us on Contact details of Project Coordinators Mr. Juras Ulbikas (juras.ulbikas@protechnology.lt) & Mr. Julius Denafas (Julius.Denafas@solitek.eu) PV module innovations introducing and combining five PV module innovations applied to c-Si based bifacial modules and CIGS modules. MULTIFUNCTIONAL COATINGS LIGHT HARVESTING Laminated By-Pass Diodes COST EFFECTIVE BARRIER LAYER FOR FLEXIBLE THIN FILM SOLAR MODULES PV module innovation transfer and costs: intermediate assessment PET sheet barrier coating front eletrode absorber back electrode PI substrate encapsulant back sheet encapsulant Modules laminated with a PET foil with nanometric Al2O3 or SiNx barrier had a similar output at 1000 hour of 85oC/85 % RH damp heat exposure as with a reference (high grade) front sheet. CIGS module on poly-imide substrate, laminated on back sheet, bonded to PET foil with Al2O3 coating. Problem description: The encapsulation costs are the main drawback for current flexible light weight applications of thin film modules. This innovation will open new market segments for building integrated PV where typical PV system cannot be applied because of their high additional weight. Time between layers Transmittance (visible light) Water Effect (Contact angle) Anti – Soiling Non Treated --- 89 --- --- AR + AS HFB 0 minutes 89 HFB 105.03º AS: √√ EtC: ≈ AR + AS HFB 5 minutes 90 HFB 121.57º AS: √≈ EtC: √√ AR + AS HFB 30 minutes 90 HFB 121.80º AS: √≈ EtC: √√ Good AR PropertiesPropertiesAnti Anti ––Powder PowderEffect EffectHFB Performance HFB Performance Estimated gain due to antireflectivity was: 1,4% for single coating 2,8% for double coating Produced and in-house coated six 60-cell modules Gain for AR + HFB easy coatings was 1.8-2.0% Gain for AR + HFL easy coatings was 0.6-1.0%Laboratory Laboratoryresults resultsof ofreal PV modules real PV modules Solar panel Bifacial solar cell White colored rear glass No power reduction due to in-laminate bypass diodes in full size PV module IV characteristics of 60-cell monofacial modules: with and without soldered Si bypass diodes Configuration Isc [A] Imp [A] Voc [V] Vmp [V] Pmp [W] with diodes 8.75 8.36 38.66 31.84 266.24 without diodes 8.74 8.38 38.62 31.81 266.42 One module: 570g silicon shards de-metalized silicon AgCl from Ag-mesylate silver from AgCl MSA/H2O2 Assessment of PV recycling for module level innovations Pyrolysis: Rapid (~5 min) thermal heat treatment (~ 500- 600 °C) – intensive gas formation, flame – burning of gas, burning of EVA Recovery of silver: Treatment of the silicon shardes from Apollon N.I.C.E. solar modules Concept • Majority of Light | poster |
Heavily present in Arab-Islamic culture, al-Andalus, Iberia under Muslim rule, inspired one of the most popular “Islamic” televisual products in the Arab world: Al- Thulathiyya al-Andalusiyya (The Andalusi Trilogy), a set of three Arabic-language historical drama television series covering relatively intermittently the geopolitical and social evolution of al-Andalus over a period that starts around 737 and ends in 1095. To deconstruct the different dramatico-historical narratives generated by the Thulathiyya, an in-depth qualitative analysis of its three seasons is conducted that explores both the social and political norms and the historical sources its scripts draw on. The trilogy’s representation of al- Andalus is assessed, in the same analysis, in its potential function of commentary on the modern sociopolitical reality of the MENA region. HISTORY OF AL-ANDALUS AL-ANDALUS IN ARABIC TV AND FILM 1- ʿAbd al-Rahmān I, the first Umayyad prince of al- Andalus (731–788). 2- Al-Ḥājib al-Manṣūr, an extraordinary ruler of al- Andalus (938–1002). 3- Al-Muʿtamid b. ʿAbbād, the last ʿAbbādid ruler of the taifa of Seville (1040–1095). - The evolution of audiovisual representation of al-Andalus in Arabic culture. - Projections of present realities onto a romanticized space-time of Islamic history. 1970S—2022 1- Historical (of the Medieval Arabic sources upon which the scripts are based); 2- Sociopolitical; 3- Computational (of the novelized scripts, using text analytics). A TRIPLE ANALYSIS ESR 15: Mounir Saifi Al-Andalus Fictionalized Audiovisually in the Arab World (Re-)Viewing Al-Thulathiyya al-Andalusiyya from a Sociopolitical Perspective AL-THULATHIYYA AL-ANDALUSIYYA 8TH CENTURY—11TH CENTURY ITN - N°813547 Secondment 2 Nov–Dec 2021 Casa Árabe Córdoba Intensive courses on: Al-Andalus; Cultural tourism Secondment 1 Aug 2020 CNMS, Philipps-Universität Marburg In-Depth Analysis of Data Collected From Social Media Platforms Nov 2020 CNMS, Philipps-Universität Marburg Social Media Scraping and Digital Data Analytics | poster |
Relativistic meson-exchange currents in lepton-nucleus scattering V. Belocchi Universit`a degli Studi di Torino & INFN, Torino valerio.belocchi@unito.it Formalism When a lepton interacts with a nucleus two -or more- nucleons in the same interaction can be ejected, yielding to a np −nh process. This is a pure nuclear effect. Specifically, we focus on the 2p2h, based on RFG. The nuclear tensor contains matrix elements: wµν ∝⟨F| ˆJ2b† µ |2p2h⟩⟨2p2h| ˆJ2b ν |F⟩ with |F⟩the Fermi sphere and |2p2h⟩the 2p2h state. ˆJ2b µ is a two-body current, that is obtained following the Meson Exchange Currents (MEC) formalism. Subedi et al., Science 320, 1476 (2008) Meson Exchange Currents MEC for the EM-EW interaction, related to ∆resonance -a,b,c,d-, ’contact’ -e,f-, ’pion-in-flight’ -g- and ’pion-pole’ -h,i- currents. J2b µ is a fully relativistic two-body current, corresponding to the coupling of the virtual boson to a pair of nucleons exchanging a pion. It is derived from the Non-Linear σ-model Lagrangian in- vestigated in [1], where the ∆resonance is incorporated ad hoc. On the right exempla of direct and exchange many-body dia- grams, included in our computations, obtained combining two MEC currents. Inclusive process In an inclusive lepton-nucleus scattering only the outgoing lepton is detected: the 2p2h cross section is obtained including every possible hadronic final state with two ejected nucleons. Lepton-nucleus inclusive cross-section: d2σ dEe′dΩe′ = σ0 Lµν ν0 W µν A WA, L nuclear and leptonic tensor We described the 2p2h hadronic tensor in a RFG framework, hence: W µν (2p2h) = 1 4 V (2π)9 X s1,s2,s′ 1,s′ 2 t1,t2,t′ 1,t′ 2 Z hi<kF pi>kF dh1 dh2 dp1 dp2 δ4(p1 + p2 −h1 −h2 −˜q) wµν ˜q := (˜ω, q), ˜ω := ω −E2p2h s , for 12C ⇒E2p2h s = 40 MeV, kF = 228 MeV Integration over holes and particles momenta ⇒less non-vanishing hadronic contributions Results We tested our model with previous inclusive calculations for the electron [2] and for the CC neutrino [3] scattering. Double differential cross section for e 12C and νµ 12C, with quasi-elastic contribution evaluated using RFG nuclear model and the 2p2h, computed using MEC. Electron data are also shown, from archive 10.48550/arXiv.nucl −ex/0603032. Inclusive EW differential cross section as a function of the scattering angle and the energy transfer ω. Incident neutrino energy Eνµ = 550 MeV, corresponding to T2K ND flux peak. Semi-inclusive process J.M. Franco-Pati˜no, PhD Thesis (2024) In a semi-inclusive lepton-nucleus scattering an outgoing nu- cleon is detected in addition to the final lepton.We computed theoretical predictions for detected nucleon p1 lying on the scattering plane, ϕp1 = 0. Lepton-nucleus semi-inclusive cross-section: d6σ dωdΩe′dEmdΩp1 = p1Ep1 (2π)3σ0 Lµν ν0 W µν A(N) W µν A(N) := d W µν A dp1 Em = ω −Ep1 + mN Integration over holes and one particle only momenta ⇒numerous non-vanishing hadronic contributions Results Semi-inclusive predictions, with incident lepton energy E=478 MeV, energy transfer ω=263 MeV, momentum transfer q=303 MeV/c and proton scattering angle θp. Left: electron-carbon scattering, in violet the pion production threshold, data from [4]; right: CC muonic neutrino-carbon scattering, similar predictions can be found in J. Niewczas, PhD Thesis (2023). The isospin separation for ejected nucleons in final state is performed. Conclusion We computed the 2p2h contribution for the inclusive and semi-inclusive lepton-carbon scat- tering, showing preliminary weak predictions. In particular, we tested the EM-MEC formalism comparing with available semi-inclusive data focused in the ’dip’ region. For details, see [5]. Currently the 2p2h component of the cross section is simulated in event generators on the basis of inclusive calculations, necessarily relying on strong approximations. The model aims to provide a reliable description of neutrino-nucleus semi-inclusive 2p2h process, for which a complete microscopic and fully relativistic computation is still absent in t | poster |
Inter textor Interfaces für die Annotation intertextueller Relationen Ein Projekt des Service Center for Digital Humanities Münster (SCDH) Jan Horstmann Christian Lück Immanuel Normann Jan-Erik Stange Dennis Voltz Benjamin Weber Mirko Westermeier Der Intertextor ist ein in Entstehung begriffenes Werkzeug zur manuellen Erfassung und Erforschung von Intertextualität als Netzwerk. Als Vorarbeit wurde ein gemeinsamer Kern von Intertextualitätstheorien heraus- gearbeitet und formalisiert, was zu einer modularen Ontologie (RDFS und OWL) geführt hat. Sie wurde auf der DHd 2023 zur Diskussion gestellt. Hier nun zeigen wir, wie auf dieser Grundlage fortschreitend Aspekte der Visualisierung und User-Experience bei der Toolentwicklung berücksichtigt werden. Texte können in verschiedenen Zoomstufen visualisiert werden, die in folgenden UI-Elementen zum Ausdruck kommen: lesbarer Text; verkleinerter Text als Struktur von Absätzen, Überschriften usw.; Balken als lineare Textrepräsentation; Knoten in einem Netzwerk. Diese UI-Elemente können auf verschiedene Weise miteinander kombiniert werden, was zu vier verschiedenen UI-Konfigurationen führt. Sie entsprechen verschiedenen wissenschaftlichen Zugängen zu Intertextualität. Wir laden euch ein, euch bei der Anforderungsanalyse, Gestaltung und techni schen Entwicklung zu beteiligen. Globales Netzwerk Synopse Das gesamte Netzwerk bildet den Hintergrund, auf dem sich die Interaktion mit den Texten abspielt. Einzelne Nodes können selektiert werden, woraufhin sich ein Textfenster öffnet, in dem markierte Text stellen und ihre Verbindungen angezeigt werden. In einem festen Set von eng aufeinander bezogenen Texten bietet das Netzwerk keinen informationel len Mehrwert. Die Texte werden parallel lesbar dargestellt. In Beziehung stehende Stellen werden her vorgehoben und Informationen zur Relation angezeigt. Dieses UI entspricht der Methode Synopse. Die zu einem Korpus gehörenden Texte werden als Balken radial angeordnet und Verbindungen zwi schen ihnen als Bogen angezeigt. Die Selektion eines Balkens öffnet eine lesbare Textansicht rechts daneben, wo mehrere Texte dargestellt werden können. Dieses UI eignet sich zum Beispiel für Korpus- oder Werk-Analysen. Ein Text steht im Zentrum. Neben seiner Darstellung als Volltext ist der Ausschnitt des globalen Netz werkes zu sehen, der die Verbindung zu anderen Texten betrifft. Über das Netzwerk lassen sich seine Verbindungen zu ihnen explorieren und in Beziehung stehende Texte als Fenster öffnen. Über einen Slider lässt sich der Ausschnitt des Netzwerkes über die direkten Nachbarn hinaus vergrößern. Diese Konfiguration ist besonders nützlich bei Annotation und Analyse intertextueller Relationen einzelner Textstellen. Für hermeneutische Zugänge und Close-Reading-Ansätze ist sie besonders wertvoll. Korpus-Netzwerk Text und Netzwerk M I T M A C H E N ? uni.ms/intertextor | poster |
Non-Cognitive Predictors of Student Success: A Predictive Validity Comparison Between Domestic and International Students OSIRIS - A 20 ton liquid scintillator detector as a radioactivity monitor for JUNO PRESENTER: Alexandre Göttel for the JUNO collaboration Motivation JUNO's requirements on LS contamination: - 10^-15 for JUNO reactor neutrinos (IBD) - 10^-17 to 10^-16 for JUNO solar neutrinos Provide LS radioactivity data during commissioning of purification systems Detector Radioactivity levels are too low for “standard” detectors → 20 tons of LS surrounded by 64 iPMTs. Enclosed in a 9*9 meter cylinder of ultra-pure water. LS flows through OSIRIS in batches. iPMTs ●“Intelligent PMT” ●Digitization in PMT base ●→ Same cable for power & readout ●→ High signal quality ●→ Trigger-less readout scheme ● ●OSIRIS is equipped with 64 iPMTs + 12 veto iPMTs Simulation Calibration Analysis Results Assuming 100 counts/day of radon on day one: Reactor requirements met in < 1 week Solar sensitivity region reached in ~ 20 days Additional limits on background for JUNO Standalone C++ software framework based on Geant4 (10.02.p03). Full detector simulation with all relevant geometry and physical processes. Deployed via git & cmake → Fast simulation → Parallel development Optical photon simulation → In line with JUNO → Quenching → Cherenkov light → Wavelength dependent Biasing external gammas An external laser will send ps pulses with a wavelength of 420 nm. 20 diffusors, controlled with fiber switches, can distribute the light over all PMTs. Source calibration Two capsules containing radioactive isotopes will be lowered into the LS volume. They will be used to calibrate the energy scale and monitor long-term changes in the detector response. An additional capsule will contain a LED for additional timing calibration. Laser calibration → Charge → s.p.e. → Timing → Energy What is being calibrated? OSIRIS exploits the fast coincidence of Bi-Po decays to monitor U-238 and Th-232 levels in LS. The analysis is very sensitive to radon contamination in the liquid scintillator, as radon events are indistinguishable from Uranium and Thorium events. After the low-level data analyses and the position/energy reconstructions are performed, a series of cuts are applied. One obtains the following energy spectra (here from simulations). The signal events are obtained through time- coincidences from events in the energy windows in the plots below. On a pure LS sample: Preliminary additional radon contamination estimation: | poster |
Understanding the Benefits of Probiotic Formula for Gut Health The gut microbiota, a diverse community of microorganisms residing in our gastrointestinal tract, plays a crucial role in maintaining our overall health. Probiotics, live microorganisms with potential health benefits, have garnered significant attention for their ability to promote gut health. In this article, we will delve into the science behind probiotic formulas, exploring their mechanisms of action and scientific evidence supporting their use in maintaining a healthy gut. Understanding Gut Health and the Gut Microbiota The gut microbiota consists of trillions of microorganisms, including bacteria, viruses, fungi, and other microbes. These microbes coexist in a delicate balance, forming a complex ecosystem that interacts with our bodies in numerous ways. A healthy gut microbiota is associated with proper digestion, efficient nutrient absorption, and a robust immune system. The Role of Probiotics Probiotics are strains of beneficial microorganisms that, when consumed in adequate amounts, confer health benefits to the host. They can exert their effects through various mechanisms, including: Gut Microbiota Modulation: Probiotics can influence the composition and diversity of the gut microbiota. They help restore balance in cases of dysbiosis, promoting the growth of beneficial bacteria while inhibiting the growth of harmful pathogens. Production of Bioactive Compounds: Probiotics can produce bioactive compounds, such as short- chain fatty acids and antimicrobial substances. These compounds support gut health by providing nutrients to the gut cells, enhancing gut barrier function, and inhibiting the growth of harmful microorganisms. Immunomodulation: Probiotics interact with the immune system, stimulating the production of immune-modulating molecules and promoting the development of a balanced immune response. This immune modulation can help alleviate inflammation and enhance immune defense against pathogens. Scientific Evidence for Probiotic Formulas Numerous scientific studies have investigated the efficacy of probiotic formulas in promoting gut health. Some key findings include: Gastrointestinal Disorders: Probiotic formulations have demonstrated benefits in managing various gastrointestinal disorders, such as irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), and antibiotic-associated diarrhea. Immune Support: Probiotics have been shown to enhance immune function, reducing the risk of respiratory tract infections and allergic conditions. | poster |
SITUACIÓN DE OBESIDAD EN LOS NIÑOS de 5° grado de primaria de las Escuelas Adventistas del Sur de Sonora Víctor Hugo Solís Valladares, Ph.D.; Helen Joceline Vidaña Espinoza. UNIVERSIDAD DE NAVOJOA A partir de los 10 a 12 años (5° o 6° de primaria) es el inicio del desarrollo sexual y corporal, por lo que la nutrición juega un papel muy importante en el desarrollo de los escolares. El objetivo de la investigación es conocer el estado nutricional de los niños que cursan el quinto grado en la escuela primaria del “Colegio del Pacífico” en Navojoa y “Colegio Obregón” en Cajeme, ambos en el sur de Sonora, México. La investigación es cuantitativa, transversal y descriptiva. La población analizada corresponde a 44 escolares (28 Colegio del Pacífico y 16 Colegio Obregón). Se utilizó una báscula digital para determinar el peso (± 0.5 gr). Para la toma de la talla se utilizó un estadímetro mecánico (SECA 216). Se desarrolló una ficha para recolección de los datos demográficos. Los datos recolectados se valoraron con las tablas de la CDC para peso y edad. Los resultados obtenidos revelan que el 72.73% (32 alumnos) tienen un estado de nutrición normal de acuerdo al peso para la edad; el 20.45% (9 alumnos) presenta obesidad y el 6.82% (3 niños) bajo peso. En términos generales un 72.73% de escolares tiene un estado nutricio normal, pero el 27.27% restante presenta un grado de obesidad o desnutrición; condiciones que deben atenderse a través de la implementación de programas educativos basados en nutrición escolar. Es por eso que la evaluación nutricional oportuna en las escuelas, puede ayudar a prevenir padecimientos en el futuro. La obesidad, en palabras de Rodríguez (2003) se define como exceso de grasa corporal o tejido adiposo. La obesidad es un problema serio de salud a nivel mundial y que se asocia a las principales causas de morbimortalidad. Actualmente se estima que el número de personas obesas asciende a 300 millones y un número mayor en países desarrollados o en vías de desarrollo (Montero, 2002:325-330). La Organización para la Cooperación y el Desarrollo Económicos (OECD) declara que a nivel mundial México se encuentra en el segundo lugar de obesidad en adultos con un 32% de su población, el primer lugar se lo lleva Estados unidos con 38.2% de su población. La región con más presencia de obesidad en México es la región norte que comprende los estados de Baja California, Baja California Sur, Chihuahua, Coahuila, Durango, Nuevo León, Sinaloa, Sonora y Tamaulipas, siendo Sonora el que tiene mayor prevalencia de obesidad infantil a nivel nacional con un porcentaje de 36.9% (ENSANUT, 2012). La obesidad en la niñez o en la adolescencia refiere Reyna (2012), tiene un impacto negativo en la salud y conlleva a una serie de enfermedades en esa etapa y, después cuando sea adulto incrementa el riesgo de enfermedades como dislipidemias, diabetes mellitus tipo 2, hipertensión, enfermedades cardiovasculares, ciertos tipos de cáncer. El propósito de la investigación fue conocer si está presente la condición de obesidad en los niños de 5° de primaria de las escuelas adventistas del sur de sonora, para tomar medidas correctivas, tales como orientación nutricional a los padres y maestros, a fin de que se logre mejorar la salud de los niños y en consecuencia, sean adultos sanos. La investigación es de carácter cuantitativo (Hernández, 2010) ya que se recopilará información numérica(peso y estatura) de cada niño de 5° de primaria de las escuelas adventistas del sur de Sonora, a fin de obtener datos medibles para dar una valoración medible del porcentaje de obesidad existente en la población analizada. Es descriptiva ya que, según menciona Gómez (2006), se evidencia una condición poblacional, en este caso, el porcentaje de obesidad de los estudiantes de 5° de primaria de los colegios adventistas del sur de Sonora. Por último, Heinemann (2003) comenta que al recopilar los datos una sola vez en un momento determinado, se habla de un análisis de corte | poster |
Study of the toxicity and the antimicrobial activity of different forms of ZnO nanoparticles: ZnO nanoparticles linked to graphene, pristine ZnO nanoparticles and ZnO nanoparticles doped with Mn Natalia Fernández-Pampín1 , Rocío Barros1, Sonia Martel Martín1 , Olavo Cardozo2,3, Andreas Stingl2, Patricia Farias2,4 , Alejandra García-Gómez5, Elisa Peña5 , Carlos Rumbo1, Juan Antonio Tamayo-Ramos 1 1 International Research Centre in Critical Raw Materials-ICCRAM, University of Burgos, Plaza Misael Bañuelos s/n, 09001, Burgos, Spain 2 PHORNANO Holding GmbH, Kleinengersdorferstrasse 24, 2100 Korneuburg, Austria 3 Post-Graduate Program on Electrical Engineering, Federal University of Pernambuco, Cidade Universitaria, Recife 50670-901, Brazil 4 Post-Graduate Program on Material Sciences, Federal University of Pernambuco, Cidade Universitaria, Recife 50670-901, Brazil 5 Gnanomat S.L., Campus Cantoblanco, Madrid Science Park, c/ Faraday 7, 28049, Madrid, Spain Contacts: nfpampin@ubu.es, crumbo@ubu.es, ja.tamayoramos@gmail.com ¡ Zinc oxide nanoparticles (ZnO NPs) have a multiple applications due to their special physico-chemical and antimicrobial properties. Moreover, they are inexpensive and less cytotoxic than others metal nanoparticles. The increasing use of the ZnO NPs in different sectors has raised concerns about their potential risks for the workers, consumers and environment. The posible toxic effects of different zinc oxide nanomaterials (G-ZnO, ZnO and ZnO:Mn) on the respiratory system and their irritant potential were evaluated. The antimicrobial activity of G-ZnO, ZnO and ZnO:Mn was analysed against Gram positive (methicillin-resistant S. aureus and vancomycin- resistant E. faecium) and Gram negative (A. baumannii and P. aeruginosa) bacteria. by reconstructed 3D human epidermal Materials • Graphene-zinc oxide nanomaterial (G-ZnO), ZnO and ZnO:Mn NPs Biological models A549 cells Reconstructed human epidermis (RhE) Gram positive and Gram negative bacteria Assays The effect of different concentrations of G-ZnO NPs on the A549 cell viability was evaluted by the MTT and neutral red (NR) assays, as well as the production of reactive oxigen species (ROS). On the other hand, the potential irritant of ZnO and ZnO:Mn NPs was determined using a RhE model. Moreover, the antimicrobial properties of the different ZnO NPs were studied in Gram positive and Gram negative bacteria by the determination of the minimun inhibitory concentration (MIC) following the CLSI guidelines. ¡ A549 cells MTT NR ROS RhE model S. aureus E. faecium A. baumannii P. aeruginosa G-ZnO ˃ 256 ˃ 256 ˃ 256 ˃ 256 ZnO ˃ 256 ˃ 256 ˃ 256 ˃ 256 ZnO:Mn ˃ 256 ˃ 256 ˃ 256 ˃ 256 Minimum inhibitory concentration (µg mL-1) #514 ¡ Introduction • The results obtained in the MTT assay showed that the G-ZnO produced a reduction of the cell viability after 24 h of treatment, while this reduction was less stronger in the NR assays. • G-ZnO NM caused a increased in the production of ROS in the studied exposure conditions. • According to the EU and GHS classification (Category 2 or Category 1), an irritant is predicted if the mean relative tissue viability of three individual tissues exposed to the test substance is reduced below 50% of the mean viability of the negative controls. Following this criteria, ZnO and ZnO:Mn NPs can be considered as non-irritant in the conditions tested. • None of the different ZnO NPs showed antimicrobial properties in the selected conditions, being their MICs ˃ 256 µg mL-1. Materials and Methods Results Conclusions | poster |
U.S. Environmental Protection Agency Office of Research and Development EPA www.epa.gov < Proportions of categories observed in LC and GC. GC workflow: Katherine Phillips, Alice Yau (Southwest Labs) LC workflow: Alex Chao, Jon Sobus, Barbara Wetmore Risa R. Sayre1,2, John F. Wambaugh1, Katherine Phillips3, Antony Williams1, Christopher M. Grulke1 1) U.S. Environmental Protection Agency, Office of Research and Development, National Center for Computational Toxicology, RTP NC 2) Oak Ridge Institute of Science and Education (ORISE) Research Participant 3) U.S. Environmental Protection Agency, Office of Research and Development, National Exposure Research Laboratory, Computational Exposure Division, RTP NC 1) Background 2) Method: Categorizing chemical origin 5) Method: Supporting NTA identification 6) Discussion Risa R. Sayre l ORCID 0000-0002-6173-8020 l sayre.risa@epa.gov A public database supporting evidence-based exposomics To support identification of likely sources of chemicals found in biological media through non- targeted/suspect screening analysis (SSA/NTA), this work-in- progress annotates chemicals with likely origin categories and adds empirically-validated substance relationships between chemicals and their in vivo transformation products to the CompTox Chemicals Dashboard1. We identify five categories of chemical origin (based on Rappaport et al 20142) of small molecules found in human blood biomonitoring samples: 1) endogenous metabolome, 2a) exogenous nutrients, 2b) markers of exposure to exogenous nutrients, 3a) xenobiotics (pharmaceuticals, pesticides, and others), and 3b) markers of exposure to xenobiotics. 1) Williams AJ, et al. The CompTox Chemistry Dashboard: a community data resource for environmental chemistry. J Cheminform. 2017 Nov 28;9(1):61. 2) Rappaport SM, Barupal DK, Wishart D, Vineis P, Scalbert A. The Blood Exposome and Its Role in Discovering Causes of Disease. Environ Health Perspect. 2014 Aug; 122(8). 3) U.S. Food & Drug Administration. Substances Added to Food (formerly EAFUS). www.accessdata.fda.gov/scripts/fdcc/?set=FoodSubstances 4) U.S. EPA Office of Pesticide Programs. Pesticide Chemical Search. iaspub.epa.gov/apex/pesticides/f?p=chemicalsearch:1 5) U.S. EPA TSCA Chemical Substance Inventory. www.epa.gov/tsca-inventory/how-access-tsca-inventory 6) Sobus JR, et al. Integrating tools for non-targeted analysis research and chemical safety evaluations at the US EPA. J Expo Sci Environ Epidemiol. 2017 Dec 29. 7) Richard AM, Williams CR. Distributed structure-searchable toxicity (DSSTox) public database network: a proposal. Mutat Res. 2002 Jan 29;499(1):27-52. 8) U.S. EPA High Production Volume Information System. http://iaspub.epa.gov/oppthpv/hpv_hc_characterization.get_report?doctype=2 9) McEachran AD, Sobus JR, Williams AJ. Identifying known unknowns using the US EPA's CompTox Chemistry Dashboard. Anal Bioanal Chem. 2017 Mar;409(7):1729-1735. This project was supported in part by an appointment to the Internship/Research Participation Program at the National Center for Computational Toxicology, U.S. Environmental Protection Agency, administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and EPA. 7) References Over 10,000 mappings of xenobiotic transformation relationships are being added to DSSTox, many of which are not currently registered in any metabolomics database. Developing methods to improve identification of these substances measured in human blood and their source categories supports active Agency research projects (e.g. for PFAS chemicals). Registration of xenobiotics and observed transformation products based on dose levels demonstrated to yield a detectable (by a known method) amount of product in a particular species and medium in a chemical library • allows development of exposure estimates • identifies candidate substances and pathways to inform future high- throughput assay research to identify | poster |
The older the diabetes, the less regular is the consultation in ophthalmology & One out of 4 diabetics will already have proliferative diabetic retinopathy at their ophthalmological consultation. Abstract citation ID: ckad160.1150 Increasing incidence of non-Hodgkin lymphoma in England, 1985–2019 Anjum Memon M Bawa1, Y Salari1, E Taylor-Gallardo1, A Memon1 1Department of Primary Care and Public Health, Brighton and Sussex Medical School, Brighton, UK Contact: a.memon@bsms.ac.uk Background: In the UK, non-Hodgkin lymphoma (NHL) is the most common hematological malignancy and 6th most common cancer overall - accounting for about 14,200 new cases and 4,900 deaths each year. After rising rapidly from the 1980s onwards, the incidence rates of NHL have broadly stabilised in several European and North American countries since the late 1990s. We conducted a retrospective population-based cohort study to examine whether similar changes in the incidence of NHL have also occurred in England from 1985-2019. Methods: Individual-level data for patients diagnosed with NHL, and the corresponding national population (denominator) data were obtained from ONS/PHE. Average annual incidence rates (AAIR) were calculated by sex, three age categories (0-34, 35- 64 and 65+ years) and seven five-year time periods (1985-89 to 2015-19). Results: During the 35-year study period, a total of 304,994 new cases of NHL were registered in England (54% males, 46% females). In young people aged 0-34 years, the AAIRs increased by 33% in males and 60% in females (from 1.8/100,000 in 1985-89 to 2.4/100,000 in 2015-19 in males, and from 1.0/100,000 in 1985-89 to 1.6/100,000 in 2015-19 in females). In middle age (35-64 years), the AAIRs increased by 54% in males and 57% in females (from 13.3 to 20.5 in males, and from 9.6 to 15.1 in females). At older ages (65+ years), the AAIRs increased by 108% in males and 102% in females (from 47.6 to 99.1 in males, and from 34.1 to 68.7 in females). In both sexes and all age categories, the disease was most frequently diagnosed at the advanced Stage 4. With regards to the socioeconomic status, the disease was relatively more commonly diagnosed in the most deprived groups. Conclusions: In contrast with many European and North American countries, there has been a steady and substantial increase in the incidence of NHL in England over the past four decades. Overall, the highest increase was observed in males (115%) and those aged 65+ years (109%). Key messages: The reasons behind this continued increase in incidence in England, which is in contrast with most European/North American populations, remain elusive and need further etiological investigation. Considering that the large majority of cases were diagnosed at the advanced Stage 4, there is an urgent need for clinical guidance to facilitate early diagnosis of NHL. Abstract citation ID: ckad160.1151 Suicidal ideation in coronary heart disease patients: the role of ethnicity and lifestyle factors Vladimı´ra Timkova´ V Timkova´ 1, A Husivargova1, L Kundratova1, I Nagyova1 1Department of Social and Behavioural Medicine, Faculty of Medicine, P.J. Safarik University in Kosice, Slovakia, Kosˇice, Slovakia Contact: vladimira.timkova@upjs.sk Background: Suicidal ideation (SI) is more prevalent in people with coronary heart disease (CHD) when compared to the general population. However, studies on protective factors against SI in people with cardiovascular diseases are still lacking. Moreover, there is less known about risk factors, such as ethnicity or lifestyle factors in SI and suicidal behavior. Thus, we aimed to examine the associations between ethnicity, lifestyle factors and SI in people with CHD when controlled for sociodemographic and clinical variables. Methods: We included 878 patients (60.0% male; 86.0% non-Roma; mean age 57.817.59 years; BMI 29.7810.39 kg/m2) with CHD. All participants completed the 36-Item Short Form Survey, Food Frequency Questionnaire, Physical Act | poster |
DIVERSIDAD DE MACROINVERTEBRADOS BENTÓNICOS EN ECORREGIONES DE ALTURA DE JUJUY (NORTE ARGENTINO) Vargas Rodríguez, Nelly Nicolaza María 2; Pereyra, Laura Cecilia 1 ; Torrejon, Silvia Elena 1,2 (1) Instituto de Ecorregiones Andinas (INECOA), CONICET, Universidad Nacional de Jujuy (Jujuy – Argentina) (2) Laboratorio de Limnología y Ecología Acuática, Cátedra de Ecología. Facultad de Ciencias Agrarias - Universidad Nacional de Jujuy. Correo electrónico: torrejonelena@gmail.com Los estudios de diversidad acuática plantean una declinación del número de taxones en relación al incremento altitudinal debido a la baja presión de oxígeno, descenso de las precipitaciones y la temperatura o a cierta homogeneidad del hábitat, entre otros. Estos trabajos se han realizado en un amplio gradiente que va desde pocos metros hasta las altas montañas. En las zonas de altura del Noroeste argentino (NOA), sobre los 3200 msnm, se han realizado algunos trabajos en humedales (vegas y ríos), generalmente a una escala local o en un hábitat particular, subestimando la gran heterogeneidad ambiental que caracteriza a estos ambientes a pesar del aspecto desértico e inhóspito de estas vastas extensiones. Determinar el patrón espacial de la diversidad de macroinvertebrados acuáticos en las ecorregiones de Puna y Altos Andes de la provincia de Jujuy, analizando los componentes alfa y beta de la diversidad de ensambles de invertebrados bentónicos entre distintas cuencas a una escala regional y considerando el aparente estrecho gradiente altitudinal (1000 m) entre sitios. OBJETIVOS INTRODUCCIÓN MATERIALES Y METODOS CONCLUSIONES A escala regional se reconocen los factores ambientales que actúan como un filtro de selección natural para las especies de la Puna y Altos Andes de la región NOA. Los grupos bioclimáticos agrupan a las cuencas en concordancia con la propuesta para la tipología bioclimática de la provincia de Jujuy (Entrocassi et al., 2014) Existe un gradiente altitudinal que aún en 1000 metros define patrones espaciales de distribución en ensambles de invertebrados bentónicos, donde se observa un incremento de la riqueza y la diversidad verdadera, con el incremento de la altitud. Los cambios en la diversidad se pueden observar a diferentes escalas, incluso cuando esta no presenta una gran amplitud. Contrariamente a lo esperado, los sitios más altos en la ecorregión de Altos Andes, presentan los mayores valores de riqueza y diversidad verdadera. RESULTADOS Se realizó un diseño a escala regional, con 19 sitios distribuidos en seis cuencas, para las ecorregiones de Puna (3200 – 4200) y Altos Andes (4500 – 4600 msnm) de la provincia de Jujuy, durante la primavera de 2015. Los sitios seleccionados representan la variedad de hábitats que se encuentran en esta región: ríos y arroyos con sedimentos finos o rocosos, aguas termales, arroyos de vegas o bofedales, vegetación sumergida y una amplitud de valores de conductividad. Las muestras se tomaron con red Surber modificada y se procesaron siguiendo la metodología estándar. Se realizó un análisis de cluster para clasificar los sitios en grupos con similitudes ambientales (temperatura media anual, precipitación media anual y altitud fueron significativos). Se comparó el resultado de los grupos bioclimáticos con la tipología bioclimática propuesta para la provincia de Jujuy (Entrocassi et al., 2014). Se comparó la diversidad alfa media entre los grupos bioclimáticos resultantes mediante un modelo lineal generalizado. Se utilizó el método de partición aditiva de la diversidad beta propuesto por Baselga (2010) y se obtuvo la diversidad beta total y sus componentes ( beta de anidamiento y beta de recambio de especies). Se revisaron 19 muestras donde se determinaron 45 taxones, contabilizando 63.260 individuos. Los sitios se ordenaron (Fig. 1) en 3 grupos bioclimáticos: 1) Río Grande – Yavi – Miraflores, 2) Olaroz – Tuzgle, y 3) Vilama, esta clasificación explica el 99 % de la variabilidad y define a la temperatura medi | poster |
OPEN ACCESS AN DER TECHNISCHEN UNIVERSITÄT BERLIN www.ub.tu-berlin.de/oa BY Lizenziert unter CC BY 4.0 | https://creativecommons.org/licenses/by/4.0 SERVICES DER BIBLIOTHEK BERATUNG Wir beraten Sie unter anderem zu • Rechten von Autorinnen und Autoren • Modellen des Open-Access-Publizierens • Möglichkeiten der Zweitveröffentlichung • Creative-Commons-Lizenzen Kontakt • openaccess@ub.tu-berlin.de • https://www.ub.tu-berlin.de/oa • https://blogs.ub.tu-berlin.de/openaccess ZWEITVERÖFFENTLICHUNGEN Viele Wege machen eine Open-Access- Zweitveröffentlichung möglich: • gesetzliches Zweitverwertungsrecht • allgemeine Richtlinien der Verlage • Sonderkonditionen für TU-Angehörige • individuelle Genehmigungen der Verlage Für TU-Angehörige prüfen wir auf Wunsch die rechtlichen Voraussetzungen und unterstützen bei der Veröffentlichung auf dem Open-Access- Repositorium der TU. HOSTING FÜR OA-ZEITSCHRIFTEN Unsere Angebote für TU-Angehörige, die selbst Open-Access-Zeitschriften gründen bzw. bestehende Zeitschriften in ein Open-Access-Modell überführen wollen: • Hosting auf der Basis der Publikationsplattform „Open Journal Systems“ (OJS) • Universitätsverlag berät und unterstützt für noch höhere Sichtbarkeit und Verbreitung der Inhalte WORKSHOPS Gern stellen wir das Themenfeld Open Access in Arbeitsgruppen oder Fachgebieten vor. Unsere Kernthemen sind • urheberrechtliche Grundlagen des wissenschaftlichen Publizierens • Open Access auf dem Goldenen und Grünen Weg • Creative-Commons-Lizenzen Bei Länge und inhaltlicher Ausrichtung richten wir uns nach den individuellen Bedürfnissen. Materialien früherer Open- Access-Workshops finden Sie im Slideshare-Konto der UB. | poster |
No 68 Attainment of Therapeutic Vancomycin Trough Serum Concentrations With Empiric Dosing In Neonates Lee Choy Ee, Suhaida Shukor, Sarah Diyana Shafie, Seah Yin Kuan Hospital Kajang NMRR-17-3080-39364 INTRODUCTION Vancomycin is commonly used to treat neonatal late-onset sepsis. It is the first-line antibiotic for treatment of infections caused by coagulase-negative staphylococci (CoNS) and methicillin-resistant Staphylococcus aureus (MRSA). However, data for dosing and monitoring of vancomycin in the local neonatal population is lacking. This study aimed to assess the percentage of neonates achieving a serum trough concentration between 10 to 20 mcg/mL with empiric vancomycin dosing. MATERIALS AND METHODS RESULTS • Of the 51 patients included, only 41% achieved target trough with empiric dosing. 22% of trough concentrations were sub-therapeutic whereas 37% were supra-therapeutic. • The mean GA was 31.8 weeks whereas mean PMA was 35.3 weeks. • On average, patients were started on vancomycin at weight of 1922.5 grams for 6.7 days. • All the supra-therapeutic trough concentrations were from the preterm group when compared to term neonates (45.2% vs 0%, p <0.05). • From this preterm group, 73% were contributed by the very preterm neonates (GA<32 weeks). The percentage decreased when gestational age increased. Similar trend of distribution was also observed in PMA category. • The occurrence of nephrotoxicity is low with only one incidence reported (defined as a doubling of serum creatinine from baseline). DISCUSSION/ CONCLUSION • Our study revealed that higher percentage of trough concentrations were supra-therapeutic (37%) compared to sub-therapeutic concentrations (22%). This was in contrary to studies conducted by Ringenberg et al. and Vandendriessche et al. which reported higher proportion of sub-therapeutic trough concentrations, 71.9% and 76.2% respectively1,2. Both were using Neofax® as dosing regimen. • This could be explained by the significant reduction of clearance in premature neonates due to diminished glomerular filtration rate in early days of life. There is marked increase in renal function which occurs over the first few weeks of life3. • We found that our premature neonatal population required lower dosages than the current recommendation. A local study conducted by Lo et al showed that the clearance of vancomycin was lower than that estimated in the Caucasian patients. Hence, it is important to consider the pharmacokinetic variability among these population4. • In conclusion, our preterm neonatal population experienced much higher occurrence of supra- therapeutic trough levels. Further studies are required to evaluate the optimal dosing regimen to achieve therapeutic trough concentrations in this patient population. Figure 1: Percentage attainment of vancomycin trough concentrations and distribution according to GA and PMA. GA= gestational age; PMA= postmenstrual age; w= week REFERENCES 1. Ringenberg T, Robinson C, Meyers R, Degnan L, Shah P, Siu A, et al. Achievement of Therapeutic Vancomycin Trough Serum Concentrations with Empiric Dosing in Neonatal Intensive Care Unit Patients. Pediatr Infect Dis J. 2015 Jul;34(7):742–7. 2. Vandendriessche A, Allegaert K, Cossey V, Naulaers G, Saegeman V, Smits A. Prospective validation of neonatal vancomycin dosing regimens is urgently needed. Curr Ther Res. 2014;76:51–7. 3. Leroux S, Jacqz-Aigrain E, Biran V, Lopez E, Madeleneau D, Wallon C, et al. Clinical utility and safety of a model-based patient- tailored dose of vancomycin in neonates. Antimicrob Agents Chemother. 2016;60(4):2039–42. 4. Lo YL, Van Hasselt JGC, Heng SC, Lim CT, Lee TC, Charles BG. Population pharmacokinetics of vancomycin in premature malaysian neonates: Identification of predictors for dosing determination. Antimicrob Agents Chemother. 2010;54(6):2626–32. GA<32w GA≥32w PMA <37w PMA ≥37w <10 mcg/mL 10–20 mcg/mL >20 mcg/mL | poster |
OSSDIP: Open Source Secure Data Infrastructure and Processes Platform that Supports Data Visiting Martin Weise 1 Tobias Grantner 1 Lukas Mahler 1 Andreas Rauber 1 Problem Description In an increasing number of settings, both researchers in academia as well as stakeholders in industry need to safe- guard access to highly sensitive data. Analyst-VM (Compute) Desktop-VM (Access) Owner-VM (Ingest) Data Owner Analyst want share data want access data provide data work requires Figure 1: Social architecture (highlight) While data sharing is being proclaimed as the future in open science, many settings do not allow for such ap- proaches due to e.g. confidentiality concerns. Methodology Based on the UK HDRA Trusted Research Environments (TRE) definition and experience of operating DEXHELPP for almost ten years. Provide highly controlled and moni- tored data visiting services, without disseminating an ac- tual copy: • Components of data anonymization and fingerprinting • Extensive logging and monitoring • Defined processes and contractual frameworks Secure Data Infrastructure The overall concept is centered around the principle of never providing access to the data node where all data is being held. For each individual analysis request: • Specific subset of the data required is extracted from the data node, and • Copied onto a dedicated Analyst-VM, together with the tools required to perform the analysis Proposal RQs, Tools, etc. Desktop-VM (Access) Proposal RQs, Tools, etc. Monitoring Logs, etc. Analyst-VM (Compute) Subset RStudio (Data Science) KNIME (Analytics) Data Node (Sensitive Data) Jupyter (Data Science) Figure 2: Data access workflow (highlight) Access to this Analyst-VM is granted to the analyst working on the task at hand – however, never directly, but only via a dedicated Remote Desktop-VM to introduce a media break and avoid any data flowing off via e.g. a tunnel. Research Activities via Data Visiting A dedicated Remote Desktop-VM is created to provide the sole access to the Analyst-VM. The Analyst then can ana- lyze the data as long as the time-out is not reached. Figure 3: Working with the raw data in Jupyter, RStudio and KNIME Our reference implementation supports open-source tools by default: • Data science: Jupyter Notebooks, RStudio, KNIME • Text processing: Libreoffice, LATEX • Programming: Python, Java, R It can be extended to support commercial software as well in the configuration files Conclusions The current state of the secure data infrastructure allows a Data Owner to invite experts (e.g. Analyst) to visit sensi- tive data on a trusted meeting point (Analyst-VM). OSS- DIP requires at least three (optimally nine) physical ma- chines on trusted hardware. Contact Technical lead Projektass. Dipl.-Ing. Martin Weise looks forward for your e-mail: martin.weise@tuwien.ac.at References [1] Project Website. https://ossdip.at/. [2] M. Weise, F. Kovacevic, N. Popper, and A. Rauber. OSS- DIP: Open Source Secure Data Infrastructure and Pro- cesses Supporting Data Visiting. Data Science Journal, 21:4, 2022. doi:10.5334/dsj-2022-004. [3] M. Weise and A. Rauber. A Data-Visiting Infrastruc- ture for Providing Access to Preserved Databases that Cannot be Shared or Made Publicly Accessible. In Pro- ceedings of the 17th International Conference on Digital Preservation, 2021. doi:10.17605/OSF.IO/VKN4R. 1Vienna University of Technology | poster |
20 Ed Baker1,2, Ben W. Price1 1Department of Life Sciences, Natural History Museum, London, SW7 5BD, UK 2Department of Electronic Engineering, University of York, York, Introduction The Natural History Museum (London) collection of recorded wildlife sound comprises mainly of field and laboratory recordings made between the 1970s and 1990s by David Ragge and Jim Reyn olds. The recordings underpin historic acoustic studies on the European Orthoptera (e.g. Ragge & Reynolds, 1998) and the taxonomy of the frogs of Mulu National Park (e.g. Dring, 1984). Where possible BioAcoustica makes links between sound recordings and preserved specimens, and the collecting of appropriate voucher specimens is encouraged for those submitting recordings. The majority of specimens for which recordings are held (including a number of holotypes) are depos ited in the Natural History Museum, London. Depositing specimens in other collections is also en couraged, and several projects will also be depositing material in the National Museums of Scotland, Edinburgh. Linking recordings to published works is also facilitated, allowing the recordings that underpin re search to be easily identified and faciliating reproducability in bioacoustic research. A description of the project canbe found in Baker et al (2015). Current Work The value of sound recordings in taxonomy is highlighted by the recent description (Heller & Baker, 2017) of a new species of the Orthopteran genus Horatosphaga that was initially uncovered by an unusual sound recording that did not match other members of the genus. The linkage of sound re cordings to museum specimens allowed the status of the new species to be confirmed. Several publications (e.g. Marshall et al, 2016) have specified BioAcoustica as a repository for sound recordings underpinning research findings, and others (e.g. Milach et al, 2015) have contributed re cordings that are linked to publictions after the original publication. Future Plans Recordings in BioAcoustica underpin the Leverhulme Trust funded Automated Acoustic Observa tories project. This project aims to use a new supertree of Orthoptera, bioacoustic analysis, and oth er trait data to create a step change in acoustic monitoring of species. References Baker E, Price BW, Rycroft SD, Hill J, Smith VS. 2015. BioAcoustica: a free and open repository and analysis platform for bio acoustics. Database 2015:bav054. Dring JC. 1984. Some new frogs from Sarawak. Amphibia-Reptilia 4(2):103 - 115. Heller K-G, Baker E. 2017. From an old sound recording to a new species in the genus Horatosphaga (Orthoptera: Tettigo nioidea: Phaneropterinae: Acrometopini). Zootaxa 4323(3):430-434. Marshall DC, Hill KBR, Moulds M, et al. 2016. Inflation of Molecular Clock Rates and Dates: Molecular Phylogenetics, Bio geography, and Diversification of a Global Cicada Radiation from Australasia (Hemiptera: Cicadidae: Cicadettini). System atic Biology 65(1):16-34. Milach EM, Martins L de P, Da Costa MKM, et al. (2015) A new species of tree crickets Oecanthus (Orthoptera, Gryllidae, Oecanthinae) in tobacco plantation from Southern Brazil, with body color variation. Zootaxa 4018(2):266. Ragge DR, Reynolds WJ. 1998. The Songs of the Grasshoppers and Crickets of Western Europe. Colchester, Essex: Harley Books; Horatosphaga raggei Heller & Baker, 2017: a new species of bush cricket first discovered from a sound recording on BioAcoustica Data linkages in BioAcoustica An online annotation tool allows for sections of voice introduction (blue), extraneous noise (red) and clear calls (green) to be identified, facilitating automatic analysis. Recordings linked to a publication (Marshall et al, 2016) on BioAcoustica. | poster |
10 12 14 16 18 20 0 40 80 120 160 t-Butanol/O2/N2, =1.0, PC = 15 bar 800 K 811 K 822 K 828 K 838 K 853 K Non- Reactive Pressure, bar Time, ms TC Validation of Kinetic Models of the Butanol Isomers at High Pressure using a Rapid Compression Machine Bryan W. Weber*, Chih-Jen Sung Department of Mechanical Engineering University of Connecticut Storrs, CT, 06269, USA Introduction and Objectives: Rapid Compression Machine: • Single, retractable, piston • Piston is pneumatically driven and hydraulically stopped • Piston is machined with crevices to control the roll-up vortex effect • Pressure and temperature from TDC reported as compressed conditions • The RCM has the ability to vary compressed temperature and compressed pressure independently • Compressed Temperature Range: 680-860 K • Compressed Pressure Range: 15 and 30 bar • Equivalence Ratio: 𝜙= 1.0, 𝑂2: 𝑁2 = 1 ∶3.76 Experimental Conditions: Experimental Analysis: • Ignition is defined by the local maximum of the time derivative of the post-compression pressure • Compressed temperature is computed using a non-reactive run, where oxygen in the mixture is replaced by nitrogen to eliminate reactions while maintaining a similar specific heat ratio Modeling Results: References: [1] Hansen, N., Harper, M.R., and Green, W.H., 7th US National Combustion Meeting, Georgia Institute of Technology, Atlanta, GA, March 20-23, 2011, paper 1B09 [2] Weber, B.W., Kumar, K., Zhang, Y., and Sung, C.J., Combustion and Flame, Volume 158, Issue 5, Pages 809- 819 doi:10.1016/j.combustflame.2011.02.005 [3] Weber, B.W. and Sung, C.J., 7th US National Combustion Meeting, Georgia Institute of Technology, Atlanta, GA, March 20-23, 2011, paper RK13 * bryan.weber@uconn.edu • Energy security and climate change are driving development of fuels from many new sources, particularly renewable bio-sources • Accurate kinetic models are required to enable design of new engine technologies to optimize operation towards emerging non-petroleum derived fuels • The butanol system is the smallest system with primary, secondary, and tertiary alcohols groups • Goal is to provide validation data using a heated rapid compression machine (RCM) at high pressures and low to intermediate temperatures Acknowledgements: This material is based upon work supported as part of the Combustion Energy Frontier Research Center, an Energy Frontier Research Center funded by the U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences, under Award Number DE-SC0001198 0 10 20 30 40 0 20 40 60 s-Butanol/O2/N2, =1.0, PC=15 bar, TC=827 K P(t), bar P'(t), bar/ms P(t), Non-Reactive Pressure, bar Time Derivative of Pressure, bar/ms Time, ms Ignition Delay, End of Compression Maximum of P'(t) P'(t) P(t) -10 P(t), Non-Reactive 10 100 1.15 1.2 1.25 1.3 1.35 1.4 Butanol/O2/N2, PC = 15 bar, = 1.0 s-Butanol i-Butanol n-Butanol t-Butanol Ignition Delay, ms 1000/TC, 1/K O2 : N2 = 1 : 3.76 10 100 1.15 1.2 1.25 1.3 1.35 1.4 1.45 1.5 Butanol/O2/N2, PC = 30 bar, = 1.0 n-Butanol s-Butanol t-Butanol i-Butanol Ignition Delay, ms 1000/TC, 1/K O2 : N2 = 1 : 3.76 Experimental Results: • Arrhenius plots of the ignition delay show a clear dependence on compressed pressure • The order of reactivity of the isomers changes at higher pressure, from 𝑛−BuOH > 𝑠−BuOH ≈𝑖−BuOH > 𝑡−BuOH at 15 bar to 𝑛−BuOH > 𝑡−BuOH > 𝑠−BuOH > 𝑖−BuOH at 30 bar • There does not appear to be a negative temperature dependence region in these data • Pressure traces from the RCM do not show two-stage ignition for any of the isomers, in either pressure range • However, there is significant pre-ignition heat release for 𝑡−butanol and 𝑛−butanol, but not as much for the other isomers • Constant volume, adiabatic simulations were performed using one recent mechanism from Hansen et al.1 • Simulations do not capture the pressure dependence of 𝑛−butanol ignition delays, under predicting at lower pressure and over predicting at higher pressure • The deviations from experiments for 𝑖− | poster |
Stone inscriptions represent irreplaceable sources of information on the ancient world, as they are often the only textual evidence preserved from the past. This is surely linked to the high durability of the stone support, which survived the test of time, although often fragmentary or corroded. It appears nevertheless that the support has been disregarded and not included in the historical interpretation of such texts. Within the ERC funded project "CROSSREADS - Text, materiality and multiculturalism at the crossroads of the ancient Mediterranean", inscriptions from Ancient Sicily are also considered from the materials point of view. Non-invasive approaches for the screening of stone supports in Sicilian epigraphy Alessia Coccato1, Germana Barone2, Paolo Mazzoleni2, Jonathan Prag1 1Faculty of Classics, University of Oxford, United Kingdom 2University of Catania, Department of Biological, Geological and Environmental Sciences, University of Catania Introduction and aims This research is supported by the ERC-funded project "CROSSREADS - Text, materiality and multiculturalism at the crossroads of the ancient Mediterranean" (Grant agreement No. 885040). The authors thank the director of the Salinas museum, C. Greco, and the staff of the museum, especially S. Ruvituso for supporting the ongoing research. In order to assess the provenance of the used lithotypes, a multi-level approach has been devised. A first screening is carried out completely non-invasively in situ by means of portable X-rays fluorescence (pXRF) and digital microscopy with infrared, visible and ultraviolet light sources, at different magnifications. The systematic acquisition of chemical data and micro-photographs is accompanied by a limited sampling on a selected set of objects, in order to perform the traditional minero-petrographic thin-section observations, additional laboratory tests (X-rays diffraction, vibrational spectroscopies), and in the case of crystalline marbles, also isotopic analyses. Methodological approach The acquisition of extensive chemical datasets, as well as of microscopic images on the inscriptions (without taking a sample) is a challenging task in itself. The data processing of the numerous pXRF spectra that are currently being acquired on inscriptions on different materials across Sicily leads to multiple options for data interpretation: semi-quantitative data (major and trace elements) will be treated with well-established multivariate analyses to evaluate chemical differences and for comparisons with reference materials. Moreover, these approaches are also being tested on the raw spectra and will be compared with the results of compositional analyses. On the other hand, the petrographic information obtainable non-invasively with DinoLite will be compared with that from thin sections (on selected samples), in order to establish their usefulness in the characterisation of both Sicilian and exotic lithotypes. conclusions and perspectives X-rays fluorescence Digital microscopy A Bruker Tracer IV-SD is used with two different settings for 60s livetime acquisitions: • 15kV, 35A, with vacuum for major elements; • 40kV, 17A for the traces. For each stone, at least 3 measurements are acquired with each setting. Adapted configuration files are created for semi- quantification in PyMCA. The Spectroscopy package of Orange Data Mining is used for multivariate analyses of the spectra. A DinoLite AM7915MZTL digital microscope with 8 adjustable white LEDs is used. Images are acquired on well-preserved surfaces of inscriptions on display, and with consistent magnifications (ca. 30-35× and 70×). Additionally, a separate set of images with 100× magnification has been moreover acquired in the laboratory on the bulk samples, for further comparisons with the conventional thin sections. It appears that both local and imported stones were used in Sicily for different types of inscriptions (public works and accounts, religious dedications, funerary texts, | poster |
BACKGROUND The fungi, Metarhizium spp., are well known as pathogens of CRB (Oryctes rhinoceros), but natural infection in the field is relatively low. Infection levels can be increased by the application of laboratory- produced Metarhizium spores into breeding sites. Artificial breeding sites (ABS) can be constructed from decomposing palm logs and associated plant waste and treated with fungus. Female CRB are attracted to the decomposing material to lay eggs, commercial aggregation pheromones can be used to increase attraction. Immature stages of CRB will become infected and die, but infected emerging adults will spread the fungus. In this study, a locally isolated strain of Metarhizium majus was tested by applying to ABS. The impact of the application on CRB population and fungus dispersal was determined. METHODS • Isolate F717 (S4) isolated from one adult CRB cadaver found in an oil palm plantation at Tetere, Guadalcanal. • Conidia production Conidia were produced on rice grains (Figure 1) using solid fermentation (Nelson and Glare 1996). • Field trial M. majus was tested by applying nil, low (100g/ABS), moderate (200g/ABS) and high (400g/ABS) doses of sporulated rice (Figure 1) to four 2 x 2m ABS arranged in a grid (Figure 2). 50 CRB larvae were added to each ABS. This design was repeated at three oil palm blocks in Guadalcanal (Solomon Islands): Tetere, Mberande and Nekama. CRB numbers (adults and larvae) inside the ABS were assessed every 2 months for 6 months. Before applying the fungus, soil samples were taken at 10m, 50m and 100m from each ABS. The soil samples were ‘baited' with CRB larvae to detect Metarhizium sp. Soil baiting was repeated at 2-monthly intervals. DISCUSSION Results showed that isolate F717 (S4) is pathogenic to CRB larvae and adults in the ABS. Soil baiting showed that M. majus spread up to 100m from treated ABS and persist for at least 6 months at some sites. M. majus may contribute to CRB control if high levels of inoculum can persist in breeding sites under field conditions. Paul Gende1, Simon Chris1, Sean Marshall2, Sarah Mansfield2, Trevor Jackson2, Laura Villamizar 2 1Papua New Guinea Oil Palm Research Association, New Britain Palm Oil, Guadalcanal Plains, Honiara, Solomon Islands 2AgResearch Ltd. Lincoln Research Centre, Christchurch, New Zealand Address for correspondence: laura.villamizar@agresearch.co.nz Performance of Metarhizium majus applied in artificial breeding sites to control larvae of coconut rhinoceros beetle (CRB) in Solomon Islands Metarhizium majus applied as sporulated rice in artificial breeding sites can spread from the treated area and persist in the field for up to 6 months RESULTS Less than 32 CRB larvae/ABS were found during the 2-monthly evaluations at Tetere and Mberande. At Nekama, between 48 and 62 CRB larvae were found in the ABS from the control treatment after 2 and 6 months while less than 35 CRB larvae were found in fungus- applied ABS at all evaluation times. CRB cadavers showing green sporulation consistent with infection by M. majus were found inside ABS and pheromone traps. Metarhizium sp. was detected in Tetere soil samples from all distances/treatments before and after the inoculation of the ABS (Figure 3), suggesting the fungus was already established in this block after a commercial product with M. majus was applied in 2017. In contrast, Metarhizium sp. was not detected in soil samples collected from Mberande and Nekama before ABS inoculation, but the fungus was detected later in soil samples from all treatments, even at 100m away from the site. Figure 1. CRB larva infected with M. majus (A), M. majus grown on agar (B) and rice (C) A A B C Figure 3. Detection of M. majus spread from the ABS using the soil baiting method Control Low rate Medium rate High rate Figure 2. Experimental plot design for assessment of M. majus performance in ABS under field conditions Artificial Breeding Sites (ABS) Pheromone traps Sampling points | poster |
API Chiara De Bastiani - chiara.debastiani@unive.it Giulia Fabbris - giulia.fabbris@unive.it | poster |
References [1]Sherry,Justine,etal."Blindbox:Deeppacketinspectionoverencryptedtraffic."ACMSIGCOMMComputerCommunicationReview45.4(2015):213-226. [2]Symantec’sEncryptedTrafficManagement(ETM).https://www.symantec.com/products/encrypted-traffic-management. [3]Conti,Mauro,etal."Analyzingandroidencryptednetworktraffictoidentifyuseractions."IEEETransactionsonInformationForensicsandSecurity11.1(2016):114-125. [4]Papadogiannaki,Eva,etal."OTTer:AScalableHigh-ResolutionEncryptedTrafficIdentificationEngine."InternationalSymposiumonResearchinAttacks,Intrusions,andDefenses.Springer,Cham,2018. [5]Cisco’sEncryptedTrafficAnalytics(ETA).https://www.cisco.com/c/en/us/solutions/enterprise-networks/enterprise-network-security/eta.html. [6]Rizzo,Luigi."Netmap:anovelframeworkforfastpacketI/O."21stUSENIXSecuritySymposium(USENIXSecurity12).2012. By 2019, 80% of all network traffic will be encrypted. Are we prepared for handling fully encrypted network traffic? 80% 2019 Encrypted Unencrypted 90% 2020 Encrypted Unencrypted 70% 2018 Encrypted Unencrypted High performance encrypted network traffic inspection using hardware accelerators Eva Papadogiannaki Giorgos Vasiliadis Sotiris Ioannidis FORTH-ICS FORTH-ICS FORTH-ICS This work has been partially supported by the European Commission under the Horizon 2020 Program through the I-BiDaaS project under Grant Agreement 780787. Example applications based on DPI Application domain Firewall, Antivirus Network security Intrusion detection and prevention system Network security Network usage characterization Network analytics Traffic monitoring and classification Network analytics Network optimization Network performance Use of GPUs • Thousands of cores • Highly parallelhardwarearchitecture • Low power consumption • Up to 11GBGDDR6memory • High memorybandwidth (upto 616GB/s) • Inexpensivecommodityhardware Background Internet traffic analysis is commonly based on techniques like deep packet inspection (DPI). The core of traditional DPI implementations is based on pattern matching, that enables searching for specific strings or regular expressions inside the packet content. With the widespread adoption of network encryption, DPI tools that rely on plain text pattern matching become less effective, demanding the development of more sophisticated techniques. Traditional DPI implementations can only extract very coarse grained information for themajority of such traffic. State of the art • Trafficdecryption andinspection • BlindBox [1],Symantec’sETM [2] • Could causeprivacy violations/ Expensiveprocessing • Traffic classification using ML techniques that examine accuracy focusing on packet metadata(e.g. packetsizes, timestamps,direction). • Contietal. [3] • Noreal implementation • Realimplementationof encryptednetworkinspectionsystemsusing packetmetadata. • OTTer [4],Cisco’sETA[5] • Proprietarysource code Our solution Motivation A framework that offers the functionality of a pattern matching engine tailored for packet metadata, such as packet sizes. This framework can be used to build different network related applications, such as firewalls, L7 filtering, or an Intrusion Detection System. The signatures are processed into an automaton. The generation of the automaton is based on the Aho- Corasick algorithm that offers simultaneous multi- pattern matching. The implementation of the automaton is DFA-based and refactored to search for integers. Why Aho-Corasick? • Preprocesses patterns to build a state machine • Simultaneousmultipattern searching • Processes theinputin asingle pass • Pattern searching can be transferred to GPU to achieve high throughput and real timeresults A high-level overview Packet processing and parallelization • Assign one network traffic flow to one thread • Packet batching to hide expensive transfers throughPCIe • Flow hashing to avoidpacketreordering • Filter outpacketretransmissions • Avoid costly packet copies and context switches with the netmap [6] module that operates in the user space (sing | poster |
Survey of pathotypes of Globodera pallida occurring in Europe Funding Non-competitive funding mechanism. Each funder only pays for the participation of their own national researchers. Total funding € 51 300 Picture 1 Picture 1 Picture 1 Goals Globodera pallida and G. rostochiensis represent a threat for potato growing countries and as such they are quarantine pests. Deployment of the H1 resistance gene has been highly effective in controlling G. rostochiensis. However, this has led to strong selection of G. pallida, which has subsequently increased in prevalence in potato fields. Different G. pallida pathotypes exist which differ in their ability to overcome various sources of resistance. The focus of this project is to gain insights into the distribution and occurrence of G. pallida pathotypes in Europe and to compare and align the standard test populations in European countries. Research consortium AU (DK), INIAV (PT), Fera Science Ltd (GB), SASA (GB), NAK (NL), UoC (PT) Contact information Project coordinator: Mogens Nicolaisen mn@agro.au.dk Key outputs and results A mini symposium will be organised at the end of the project. The event will allow to share the results and knowledge produced in the framework of the project with official laboratories and national authorities Objectives During the project, information will be shared in order to: • share information on the presence and distribution of G. pallida in the partner countries over time • use DNA markers for the molecular characterization of the collected material • improve knowledge on G. pallida collections across the partner countries and to collect reference material • compare the standard test populations in the partner countries for official resistance testing and determine how they differ in virulence 06/2021-05/2024 | poster |
Methods Processing: Characterization: INFLUENCE OF THE VISCOSITY ON THE DEGRADATION DURING PROCESSING OF PETG CENTRE FOR POLYMERS AND MATERIAL TECHNOLOGIES (CPMT) Hannelore Ohnmacht, Lynn Trossaert, Mariya Edeleva, Dagmar R. D’hooge and Ludwig Cardon Introduction During processing, polymers are often subjected to high temperatures and high shear rates during the (long) residence times inside the machine. This can cause the material to degrade, leading to structural changes in the polymer chain and thus an overall change of material properties. The main sorts of degradation that occur for (co)polyesters include thermal, oxidative, and hydrolytic degradation, which can lead to discoloration due to functional groups formation, crosslinking, or chain scission. Chain scission, being the main degradation mechanism for PET, refers to the rupture of polymer chains and can be induced by the presence of oxygen, water, or high temperatures. It results in smaller polymer chains, leading to a decrease of molecular weight of the polymer and consequently deterioration of material properties. This contribution examines the influence of three different viscosity grades on the degradation during processing of PETG. By analyzing the inherent viscosity and melt flow index of the material before and after processing, changes in the flow behaviour can be determined. Materials • 1,4-cyclohexylene dimethanol-modified polyethylene terephtalate (PETG) = TPA + EG + CHDM (≤ 50%) • 3 viscosity grades: • Low Viscosity (LV) • Medium Viscosity (MV) • High Viscosity (HV) Results Determination of processing parameters: Filament extrusion + FFF Injection Moulding Conclusion • Higher processing temperature needed for the HV grade due to incomplete filling of the mould • MFI and IhV confirm that chain scission is the main degradation mechanism • For 3DP parts, stepwise increase in MFI after every processing step • ~ degradation for LV and MV grades after FFF and IM • HV IM grade higher degradation after IM shear causes mechanochemical chain scission + higher T and shear heating might cause additional thermal degradation Contact hannelore.ohnmacht@ugent.be www.ugent.be/ea/match/cpmt/en Universiteit Gent @ugent Ghent University Drying of the pellets 65°C – 6h as Tg = ±80°C 1. Filament extrusion Brabender 19 single screw 2. FFF Brabender 19 single screw Injection Moulding Engel e-victory 28T Melt flow index measurements: • MFI ~ 1/η and η ~ Mw • After every processing step (FE and FFF) stepwise MFI increase of ± 2 • ~ degradation for FFF + IM parts for LV and MV • HV parts underwent significant degradation during injection moulding Inherent viscosity measurements: • To evaluate the quality of the material • Losses between 0 - 5 % well dried and processed • IM HV grade, the IhV loss is 17% significant degradation confirm MFI results due to shear ( mechanochemical chain scission) + shear heating (thermal degradation) IM FFF Melt flow index (MFI) Davenport 10 ISO 1133-A (240°C – 2,16 kg) Inherent Viscosity (IhV) Viscotek Y501C differential viscometer | poster |
Analyse des Status Quo[1] Standortspezifische Bestands- und Bedarfserhebung[2] Identifikation FDM-bezogener Communities Strategie- entwicklung Governance- Modelle Selbstevaluation mit RISE-DE3: Feststellung des Ist-Zustands im FDM bzw. der Reifegrade der vier Einrichtungen Ermittlung der Anforderungen von Forschenden, EXCs, SFBs und anderen Verbundvorhaben Themen- und fachspezifische Workshops Empfehlungen für FDM-Services, -Tools und Infrastrukturen Evaluation verschiedener Governance- Modelle METHODEN UND MASSNAHMEN ZIELE Konzeptentwicklung zum bedarfsorientierten Aufbau übergreifend nutzbarer Kompetenz, Expertise und Ressourcen zum Handlungsfeld FDM für Forschende und Multiplikator*innen Auf- und Ausbau nachhaltiger, institutionsübergreifender FDM-Services WEB PUBLIKATIONEN Ariza de Schellenberger, A., Bobrov, E., Helbig, K., Jäckel, D., Kuberek, M., Orozco Prado, L.-S., Schlagberger, E. M., Söring, S., & Steinke, B. (2022). Bestands- und Bedarfserhebung zum Forschungsdatenmanagement an den BUA-Einrichtungen (Version 1). Zenodo. https://doi.org/10.5281/zenodo.7060446 Ariza de Schellenberger, Bobrov, E., Helbig, K., Jäckel, D., Kuberek, M., Orozco Prado, L.-S., Schlagberger, E. M., Söring, S., & Steinke, B.: Stärkung von FDM- Services im Verbund – Ergebnisse einer Bedarfserhebung, in Heuveline, Vincent, Bisheh, Nina und Kling, Philipp (Hrsg.): E-Science-Tage 2023: Empower Your Research – Preserve Your Data, Heidelberg: heiBOOKS, 2023, S. 270–275. https://doi.org/10.11588/heibooks.1288.c18087 Förderkennzeichen: 501_CRDMS Referenzen [1] Ariza de Schellenberger et al., 2023, DOI: 10.17192/bfdm.2023.1.8551 [2] Ariza de Schellenberger et al., 2022, DOI: 10.5281/zenodo.7060446 [3] ] Hartmann et al., 2019, DOI: 10.5281/zenodo.3585556 Auf- und Ausbau von FDM-Services in der Berlin University Alliance Concept Development for Collaborative Research Data Management Services (BUA-FDM) Collaboratively Advancing Research Data Support (CARDS) 03.2021 – 06.2023 05.2024 – 10.2026 FAIR-konformes Datenmanagement an den BUA-Einrichtungen Vereinfachte Planung und Durchführung forschungsdatenbasierter Vorhaben in Verbund- und/oder Projektkontexten der BUA Kompetenzausbau im Handlungsfeld FDM bei den Forschenden der BUA Breite Verankerung von FDM im Verbund BUA Customised Research Data Management Organiser (RDMO) (TU) Data Stewardship in Exzellenzclustern (Charité) FDM-Kompetenz- entwicklung (FU) BUA-spezifische Erweiterungen für RDMO; Erleichterung der DMP-Erstellung für BUA-Forschende Professionalisierung des Datenmanagements in Exzellenzclustern, Steigerung der Datenqualität und - nachnutzbarkeit Ausbau übergreifender, u.a. aggregierter FDM- Schulungs- und Trainingsangebote; Kooperationen mit regionalen und nationalen Initiativen KONTAKT bua-fdm@lists.fu-berlin.de https://www.berlin-university- alliance.de/commitments/sharing-resources/fdm Einsatz von elektronischen Laborbüchern (HU) Konzeption, Architektur- und Betriebsmodell für die BUA-übergreifende Einführung von ELN-Systemen ZIELE https://www.berlin-university-alliance.de/commitments/sharing-resources/fdm/ | poster |
Teaching with eXtended Reality – Evaluating the MirageXR Authoring Tool What is this pilot about? Pilot 4 aims to accelerate the uptake of AR in e d u c a t i o n , by providing an authoring tool and learning management system to teachers. We believe that introduction at scale requires to put tailored authoring tools in the hands of teachers to support the production of bespoke AR learning experiences for the mainstream as well as for the Long Tail. The MirageXR platform is user-friendly and does not require any prior AR experience. Participation is on a voluntary basis, as a choice under free will. Target Group We are looking for teachers who: • • have a good level of English language (B2 in Reading and B1 in Writing + Speaking) • • are pre-service or in-service teachers • • are willing to participate • • have an AR-compatible iOS2 or Android3 phone or tablet The Outcome With this pilot study (ARETE Pilot 4), we seek to evaluate quantitatively and qualitatively, in which ways and how well our authoring toolkit supports teachers in designing XR learning experiences. ARETE PILOT 4 | poster |
EmulsifiersfromNaturalResources: TheRoleof LecithininEmulsionFormationfromMolecular Dynamics Dinais Alvarez1, Deisy Giraldo2, Cristian Blanco2, Marianny Combariza2 and Aldo Combariza1 1Grupo Investigación Modelamiento Molecular y Simulación Computacional in silico, Departamento Biología y Química, Universidad de Sucre; 2Grupo Investigación Fisicoquímica Teórica y Experimental GIFTEX, Escuela de Química, Universidad Industrial de Santander, Colombia Motivation Molecular Dynamics simulations can be applied to the study of physico-chemical parameters as interfacial tension of emulsions, e. g., a water-in-oil interface.[1] • Amphiphilic compounds as lecithins, are used as emulsi- fiers • Lecithins are a mix of Phospholipids (PLs), Triacylglicery- des (TAGs), and others compounds a. Phosphatidylcholine (POPC) as the commonness in lecithins., b. Di-oleoyl-linoleoyl-glycerol OOL as TAG. Computational Approximation From ensembles (Eqn. 1) < V >= ZZ V (pN, rN)ρ(pN, rN)dpNdrN (1) Using forcefields: Charmm 36 FF to model intramolecular inter- actions (Eqn. 5). V ( ˆR) = X bonds Kb(b −b0)2 + X angles Kθ(θ −θ0)2 (2) + X dihedrals X j Kϕj(1 + cos(njϕ −δj)) (3) + X non−bonded−pairs−ij εij[( Rmin,ij rij )12 −( Rmin,ij rij )6] (4) + X non−bonded−pairs−ij qiqj εDrij (5) Surface tension can be measured applying the Kirkwood-Buff ex- pression (Eqn. 6) γKB = L 2 ⟨P⊥−P∥⟩ (6) All minimization and production runs were carried up using the INKARI High Performance Computational Scientific Cluster lo- cated at the Universidad Nacional de San Agustín (UNSA), Are- quipa, Perú, which features a Silicon Graphics U-Racked Cluster with Head Node SGI 2x AMD-Opteron processors, twelve-core, 2.4 GHz, 64 GB of RAM memory DDR3 1600 MHz 4 Discs of 2TB SATA 7200 RPM, 12 Server Nodes (9x SGI), each Node server with 2 AMD Opteron twelve-core processors, 2.4GHz, 64 GB of RAM memory DDR3 1600 MHz 3 SATA 2TB Disks 7200 RPM. All simulations were set-up using the GROMACS V. 2019 Molecular Dynamics code. System Definition and Details Based on an emulsion model with 80:20 volume proportion (80 mL TAG and 20 mL water) we calculated the number of molecules. Compound %Vol Vol (mL) Molar mass (g/mol) # Moles Molecules Ratio Total TAG 80 80 885.000 8.28E-02 4.98E+22 1 100 a Water 20 20 18.0150 1.11E+00 6.67E+23 13.4 1337 Compound % Mass Mass (g) Molar mass (g/mol) # Moles Molecules Ratio Total PPL 20 20 760 2.63E-02 1.58E+22 3.18E-01 34 The Volume Guesser extension from Packmol official webpage was used to estimate the volume of the system considering a volume per molecule as a proportion of its molar mass. Compound Molecules Density (g / mL) Molar Mass (g / mol) System Volume (Å3) Box Sides (Å) Water 1340 0.999 18.015 40117.12 34.26 OOL 100 0.9156 885 160508.02 54.35 PPLb 34 0.917 760 44040.6 35.31 The estimated volume of each PPL, TAG and WATER interface in the Z dimension is shown. According to this proportions, Packmol software was used to construct and pack all interfaces. Phase/Compound Vol. Å3 Box of side Å Size on X Size on Y Size on Z. Water 40117.12 34.26 47 47 26 OOL 160508.02 54.35 47 47 67 PPL 44040.63 35.31 47 47 28 aDensity of TAG was obtained from experimental density value of sunflower oil. bDensity for PPL was obtained from experimental density of soybean oil Framework Simulations and Dynamics Cell with parameters: A, B and C = 6.04350, 5.94580, 15.97680, respectively and a cubic box with al- pha=beta=gamma=90, resulting in a box of 574,10 Å. Water phase with 1337 molecules 34 molecules of POPC with polar heads oriented towards the water OOL interface of 100 molecules interacting with the POPC tails POPC interface with 34 molecules Another water interface of 1337 molecules First step: Energy Minimization • Steepest descendent optimization for 50000 steps • Electrostatic interactions were established by the Particle Mesh Ewald PME algorithm with a cut-off of 1.2 and a Van der Waals cut-off distance of 1.2. • Periodic boundary conditions PBC were applied in all direction | poster |
Motivation ArXiv:1909.04044, Miguel Escudero[a] and Sam Witte[b] [a] King's College London, [b] Instituto de Física Corpuscular Conclusions and Outlook References [1] Riess et. al. 1903.07603. Astrophys. J. 876 (2019) 85. [2] Planck Collaboration, 2018 Cosmological Parameters, 1807.06209. [3] The Hubble Hunter's Guide, L. Knox and M. Millea, 1908.03663. [4] Y. Chikashige, R. N. Mohapatra & R. D. Peccei, Phys. Lett B98 (1981) 265-268. [5] Z. Chacko, L. J. Hall, T. Okui & S.J. Oliver, PRD 70 (2004) 085008, hep-ph/0312267. [6] M. Escudero, JCAP 1902 (2019) 007, 1812.05605, 2001.04466. [7] M. Escudero & S. J. Witte 1909.04044. Corresponding Author: miguel.escudero@kcl.ac.uk NuPhys2019: Prospects in Neutrino Physics (London) Could the Hubble Tension be Pointing Towards the Neutrino Mass Mechanism? m⌫6= 0 ⌫e ! ⌫µ ¯⌫ ⌫ φ H0 The Hubble Tension Neutrino Masses The Scenario Physics beyond ΛCDM? Physics beyond the SM 4.4σ discrepancy between the local determination of the Hubble constant [1] as measured using Cepheids and type-Ia SN to the value inferred from Planck CMB observations within ΛCDM [2]. Planck data has been exhaustively checked against systematics and CMB systematics cannot be responsible for the tension. Several groups have reanalysed the local measurements and so far there is no known systematic capable of substantially ameliorating the tension. Strong lensing measurements of H0 are in agreement with local determinations while Baryon Acoustic Oscillations agree with the CMB. Neutrinos oscillate and at least two of them have a mass. Neutrino masses are the only laboratory evidence of physics beyond the Standard Model, since mνSM = 0. Viable solutions to the tension require an enhanced expansion history close and prior to recombination. However, simply enhancing Neff does not work [2,3]. Furthermore, BBN constraints typically apply. The Majoron: a Neutrinophilic pseudo-Goldstone boson from the seesaw mechanism with Global Lepton number Neutrino masses via the type-I seesaw mechanism But heavy neutrino Majorana masses should come from somewhere. Here, via the spontaneous symmetry breaking of U(1)L. Majoron Properties Cosmological Implications Main Results If Lepton number is a global symmetry (as in the SM) then a physical pseudo-Goldstone boson appears in the spectrum: the Majoron [4]. Very feeble interactions with neutrinos λ ' 10−13 m⌫ 0.05 eV 1 TeV vL Extremely weak interactions with matter λφee ' 10−20 Gravity breaks all global symmetries. Dim-5 Planck suppressed operators: Lint = iλ φ ¯⌫γ5 ⌫ ¯⌫ ⌫ φ Performed a full MCMC fit to Planck2018 data and found very strong constraints ⚑. Ruling out masses compatible with dim-5 Planck suppressed operators ⚑ and testing couplings as small as λ ~ 10-13 and scales of lepton number breaking up to 1 TeV. Γφ ≥H(T⌫= mφ/3) Neutrino-Majoron interactions lead to [5]: Non-standard expansion history between BBN and recombination. Erase of the Neutrino anisotropic stress. provided We account [7] for these effects by solving the background evolution using [6] and by implementing in the Boltzmann code CLASS the non- standard expansion history and the impact on the neutrino perturbations. λ ⌧1 equivalently λ > 4 ⇥10−12 r mφ 1 keV Impact on the CMB Γe↵= ✓ λ 4 ⇥10−12 ◆2 ✓1 keV mφ ◆ Non-standard expansion history Leads to a contribution of across wide regions of parameter space. ∆Ne↵' 0.11 Modification to the neutrino perturbations Leads to a suppression of the neutrino anisotropic stress that has very important implications for the CMB spectra. ˙δ⌫φ = −4 3✓⌫φ −2 3 ˙h , ˙✓⌫φ = k2 ✓1 4δ⌫φ −σ⌫φ ◆ , ˙F⌫φ2 = 2 ˙σ⌫φ = 8 15✓⌫φ −3 5kF⌫φ 3 + 4 15 ˙h + 8 5 ˙⌘−2aΓσ⌫φ , ˙F⌫φ ` = k 2` + 1 ⇥ ` F⌫φ (`−1) −(` + 1)F⌫φ (`+1) ⇤ −aΓF⌫φ ` , ` ≥3 . Γ = Γφ 2 m2 φ T 2⌫ e µ⌫ T⌫K1 ✓mφ T⌫ ◆ Γφ ' λ2 16⇡mφ Since , the only relevant processes are Majoron decays and inverse neutrino decays: The Majoron leads to across wide regions of parameter space ⚑ and hence ameliorates the Hubble tension without suffering from BBN constraints | poster |
[1] Matteucci, F. 2008, in Massive Stars as Cosmic Engines, ed. F. Bresolin, P. A. Crowther, & J. Puls, Vol. 250, 391–400; [2] Hopkins, P. F., Kereš, D., Oñorbe, J., et al. 2014, MNRAS, 445, 581; [3] Garcia-Segura, G., Mac Low, M. M., & Langer, N. 1996, A&A, 305, 229; [4] Krause, M., Fierlinger, K., Diehl, R., et al. 2013, A&A, 550, A49; [5] Kudritzki, R.-P. & Puls, J. 2000, ARA&A, 38, 613; [6] Kudritzki, R. P., Bresolin, F., & Przybilla, N. 2003, ApJL, 582, L83; [7] Bromm, V., Kudritzki, R. P., & Loeb, A. 2001, ApJ, 552, 46; [8] Heckman, T. M., Borthakur, S., Overzier, R., et al. 2011, ApJ, 730, 5; [9] Belczynski, K., Holz, D. E., Bulik, T., & O’Shaughnessy, R. 2016, Nature, 534, 512; [10] Marchant, P., Langer, N., Podsiadlowski, P., Tauris, T. M., & Moriya, T. J. 2016, A&A, 588, A50; [11] Dalton, G., Trager, S., Abrams, D. C., et al. 2020, SPIE Conf. Ser., 11447, 1144714; [12] Jin, S., Trager, S. C., Dalton, G. B., et al. 2024a, MNRAS, 530, 2688; [13] Monguió M., et al., 2020, A&A, 638, A18; [14] Pantaleoni González, et al., in prep.; [15] Pantaleoni González, M., Maíz Apellániz, J., Barbá, R. H., & Reed, B. C. 2021, MNRAS, 504, 2968; [16] Bailer-Jones, C. A. L., Rybizki, J., Fouesneau, M., Demleitner, M., & Andrae, R. 2021, AJ, 161, 147; [17] Simón-Díaz, S., Pérez Prieto, J. A., Holgado, G., de Burgos, A., & Iacob Team. 2020, in XIV.0 Scientific Meeting (virtual) of the Spanish Astronomical Society, 187 An up-scaled endeavor for exploring OB stars in the Milky Way within the WEAVE-SCIP survey A. de Burgos(1,2), S. Simón-Díaz(1,2), J. Drew(3,4), M. Monguió(3,5), S. R. Berlanas(1,2), A. Herrero(1,2), the WEAVE-SCIP collaboration Context and motivation The study of massive OB stars significantly contributes to our comprehension of galaxies [1,2]. Despite their importance, OB stars gather many open questions concerning both their evolution and physical properties that remain unanswered. In this context, the Milky Way is a perfectly suited laboratory to study them. Spectroscopic observations of statistically significant samples of these stars are needed to address those questions. In this regard, the WEAVE-SCIP [11,12] Low-Resolution (LR; R=5000) survey aims at building the largest and most homogeneous spectroscopic sample of OB stars up to date, covering most of the Northern Galactic disk. (1) Instituto de Astrofísica de Canarias (Spain), (2) University of La Laguna (Spain), (3) University of Hertfordshire (U.K.), (4) University College London (U.K.), (5) Universitat de Barcelona (Spain), Ph.D. Student IAC Progenitors of gravitational wave emitters[9,10] Tracers of star-forming regions Feedback to the interstellar medium[3,4] Chemo- dynamical evolution of galaxies[1] Reionization of the Universe[7,8] Extragalactic tools[5,6] Building the catalog for the survey IPHAS (Hα, Sloan r, i) + UVEX (URGO, Sloan g, r) |b| < 5° and 29° < l < 215° Bad sources ❌ Saturated sources ❌ Missing photometry ❌ 10.0 < gUVEX < 17.5 ❌ Data retrieval from IGAPS[13] Initial filter U,g,r Selection filter Additional filters For each IGAPS field, a U-g / g-r diagram with a U-band correction was initially used to select 54.000 sources earlier than B3V star. 2MASS J,H,K and Gaia DR3 were used to remove unwanted sources. Using ALS III and Gaia DR3 Additional ~4000 targets from the Alma Luminous Star III (ALS III)[14,15] of OBA-type stars were added. Gaia DR3 photometry and distances from Bailer-Jones et al. (2021)[16] were used to filter out ~25.000 sources located below the extinction line of a 7M⊙ star. Very different reddenings → The OB candidates of the WEAVE-SCIP LR survey ● Magnitudes: 10 < G [mag] < 16 ● Distances: 2000 < d [pc] < 8000 ● A total of 410 pointings distributed in the Galactic plane. ● A maximum of 150 fibers per pointing. ● Different priorities are assigned based on the location of the targets in the different diagrams. ● About 5000 targets have the highest priority and they lie above the 15M⊙ extinction line. Conclusions The U-band correction The | poster |
Poster template by ResearchPosters.co.za Mode-cleaning in Non-Hermitian Fibers and Waveguides M. N. Akhter1, R. Herrero1, M. Botey1 and K. Staliunas1, 2 1Departament de Fisica, Universitat Politecnica de Catalunya (UPC), Rambla Sant Nebridi 22, 08222, Terrassa, • Barcelona, Catalonia, Spain 2Institucio Catalana de Recerca i Estudis Avancats (ICREA), Passeig Llus Companys 23, E-08010, Barcelona, Spain Abstract Motivation Non-Hermitian GRIN MMF GRIN MMF 𝜙index modulation gain/loss modulation core radius Unidirectionality (2+1)D Linear Schrödinger Equation [5] 𝜕𝐴 𝜕𝑧= 𝑖1 2 𝛻2𝐴−𝑖∆ 𝑟𝑐 2 (𝑥2+𝑦2)𝐴+ 𝑖𝒎𝒓𝒆𝒄𝒐𝒔𝒒𝒛+ 𝒊𝒎𝒊𝒎𝒄𝒐𝒔𝒒𝒛+ 𝝓𝑽(𝒙, 𝒚)𝐴 𝜙 index modulation gain/loss modulation index modulation • Non-Hermitian potential: index and gain /loss modulation • Unidirectional, asymmetric, mode coupling • 𝑽(𝒛) ∝𝒄𝒐𝒔𝒒𝒛−𝒊𝒔𝒊𝒏(𝒒𝒛) = 𝒆𝒙𝒑−𝒊𝒒𝒛 • Couples any mode 𝑘𝑧with 𝑘𝑧−𝑞only • Hermitian potential [4]: only index modulation • Bidirectional, symmetric, mode coupling 𝑽𝒛𝒄𝒐𝒔𝒒𝒛= 𝟏 𝟐{𝒆𝒙𝒑𝒊𝒒𝒛+ 𝒆𝒙𝒑−𝒊𝒒𝒛} • Couples any mode 𝑘𝑧with 𝑘𝑧+ 𝑞and 𝑘𝑧−𝑞 Results: Antisymmetrically modulated non-Hermitian potential Conclusions Non-Hermitian potential controls the mode dynamics in parabolic multimode waveguides. Depending on the spatial delay between the real and imaginary part, higher or lower order modes are favored. Mode cascading towards lower order modes leads to effective all-optical spatial mode-cleaning. Different geometries of the potential leads to different mode coupling in 2D case. 1. J. Medina Pardell, et al. Opt. Exp. 29, 23997-24009 (2021). 2. S. Benadouda Ivars, et al. Phys. Rev. A 105, 033510 (2022). 3. K. Krupa, et al. Nature Photon 11, 237–241 (2017). 4. C. Mas Arabí, et al. Phys. Rev. A 97, 023803 ( 2018). 5. M. N. Akhter et al. Phys. Rev. Lett. 131, 043604 (2023). References This Project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 861152. https://mefista.astonphotonics.uk/ [3]. 𝜕𝐴 𝜕𝑧= 𝑖𝑑𝛻2𝐴−𝑖𝑐𝑥2𝐴+ 𝑖𝒎𝒓𝒆𝒄𝒐𝒔𝒒𝒛+ 𝒊𝒎𝒊𝒎𝒄𝒐𝒔𝒒𝒛+ 𝝓 𝒙 𝒙𝟎 𝒆 −𝒙𝟐 𝒙𝟎 𝟐 𝐴 𝐴𝑥, 𝑧= 𝑛 𝑎𝑛𝐻𝑛𝑥𝑒−𝑖𝑛𝑞𝑧 ∂𝑎𝑚 ∂𝑧= 𝑎𝑚𝑖𝛽𝑚+ 𝑖𝑚𝑞+ 𝑖𝑚+𝐶𝑚+1,𝑚𝑎𝑚+1 + 𝑖𝑚−𝐶𝑚−1,𝑚𝑎𝑚−1 𝑖Δ𝑞1 𝑖𝑚+𝐶21 0 ⋯ 0 𝑖𝑚−𝐶12 𝑖Δ𝑞2 𝑖𝑚+𝐶32 ⋯ 0 0 𝑖𝑚−𝐶23 ⋱ ⋮ ⋮ ⋮ ⋮ ⋮ ⋱ 𝑖𝑚+𝐶𝑛,𝑛−1 0 0 ⋯ 𝑖𝑚−𝐶𝑛−1,𝑛 𝑖Δ𝑞𝑛 One dimensional waveguide Two dimensional fiber 𝐈 𝑽𝒙, 𝒚, 𝒛= 𝑽𝒛𝑽𝒙, 𝒚= 𝑽(𝒛) 𝒙 𝒓𝟎 𝒆 −𝒙𝟐+𝒚𝟐 𝒓𝟎 𝟐 𝐈𝐈 𝑽(𝒙, 𝒚, 𝒛) = 𝑽(𝒛) 𝒙+ 𝒚 𝒓𝟎 𝒆 −𝒙𝟐+𝒚𝟐 𝒓𝟎 𝟐 (1+1)D Linear Schrödinger Equation index modulation gain/loss modulation index modulation gain/loss modulation We propose an all-optical control of the mode dynamics in multimode waveguides, by simultaneous modulation of the refractive index and of the gain/loss coefficient. The induced unidirectional mode-coupling, yields to the enhancement or reduction of the excitation of higher order transverse modes, depending on the modulation parameters [1, 2]. In the latter case, the all-optical mode-cleaning is observed. We analytically predict the effect on a coupled mode theory for 1D waveguides, which is numerically proven solving the wave propagation equation. The proposal is generalized to the more involved case of 2D waveguides for different geometrics. Analytics Eigenmodes as a function of the spatial delay (𝝓) Numerical Maps in Parameter space One dimensional mode-cleaning Different geometries of the potential Δ𝑞𝑚= 𝛽𝑚+𝑚𝑞 𝑂𝐼𝑛= 𝐴× 𝐻𝑛𝑑𝑥 2 𝐴2 𝑑𝑥× 𝐻𝑛2 𝑑𝑥 𝑚𝑟𝑒= 𝑚𝑖𝑚= 1.5 × 10−4, 𝜙= 𝜋, 𝑞= 0.9 Δ𝑘𝑧 𝐶𝑛𝑚= 𝐻𝑛𝐻𝑚 𝑥 𝑥0 𝑒 −𝑥2 𝑥02 𝑑𝑥. | poster |
Mesa OpenEye OpenBabel CDK UNM Division of Biocomputing public web applications: Computational tools for cheminformatics and molecular discovery Jeremy Yang, Division of Biocomputing, University of New Mexico, Albuqueruqe, New Mexico, USA ChemAxon US User Group Meeting, Boston, September 13-15, 2010 ● Public web applications ● To benefit and engage the scientific community ● Cheminformatics and biomolecular discovery ● http://pasilla.health.unm.edu ● Employs diverse set of commercial, open- source and community-based components ● Limited bandwidth; etiquette essential WWW reigns! Now superpowered. Over the roughly 15 year history of the world wide web (WWW) the prevalence and usefulness of web applications has increased continuously. The “Web OS” paradigm is increasingly a reality, given tools such as GoogleDocs and Microsoft Office Web Apps, web services and cloud computing. Although web apps are not new per se, greatly enhanced capabilities are available via web apps now due to continual and dramatic improvements in (1) network bandwidth, (2) processor power, (3) web software development methods and (4) online data resources. In short, each year we can in practice do things with web apps we could not the year prior. What has not changed is the primary motivation for adoption of web apps: Deploying functionality via web apps is efficient and reliable for users, developers and managers. In addition and importantly (and this has changed somewhat as web UIs have become more complex), by virtue of their common features, web apps are generally easy to use. Web apps in cheminformatics In cheminformatics, the emergence of high quality programming toolkits, both commercial and community-based, has facilitated web app development with highly diverse aims and methods. Major software providers such as Daylight, Accelrys, ChemAxon and Chemical Computing Group have embraced web technologies, understanding their advantages and broad appeal. Web apps can vary from large scale enterprise tools (e.g. database access) to special purpose rapid prototypes for researching new algorithms. Diverse areas of research have been addressed with web apps, from toxicology prediction to 3D macromolecular visualization to quantum chemistry. Science enabled via WWW Web apps can also amount to a sort of scientific publishing. Whereas a journal article on computational methodology can leave many questions, and just as a picture can be “worth 1000 words”, arguably a functioning program might be worth 1000 pictures. In addition, agencies funding public research (such as NIH), where outcomes include computational methodology, quite reasonably and wisely require that such methodology and software be disseminated in effective, extensible, sustainable ways. Web apps developed with modern software engineering standards can well achieve these goals. Recently our app smartsfilter was used for a tuberculosis study1. ChemTattoo: colorized commonalities4 UNM Division of Biocomputing The UNM Division of Biocomputing is a multi-disciplinary research group within the Dept. of Biochemistry and Molecular Biology, in the UNM School of Medicine. Research areas include drug discovery, drug informatics, cheminformatics, bioinformatics, machine learning, QSAR, lead and probe identification. A major effort of the group is providing biomolecular screening informatics support for the UNM Center for Molecular Discovery (UNMCMD), an NIH Roadmap Molecular Libraries Programming screening center. As with UNMCMD, a long-term collaboration with Givaudan Flavors S&T has involved web apps and contributed to their development. These activities, and various other projects with collaborators who are geographically diverse, have motivated extensive use of web apps. ●Tudor I. Oprea (chief) ●Cristian Bologa ●Stephen Mathias ●Jerome Abear ●Oleg Ursu ●Gergely Zahoransky-Kohalmi ●Jeremy Yang Division of Biocomputing Personnel: Rapid prototyping enables research For scientific research web apps provide | poster |
MTLH is AFPT‘s solution for fast and reliable tape laying processes. It was built specifically for reinforcing metal sheets, thermoplastic parts or producing composite laminates. It allows the flexibility to lay 2“ wide tapes or 3 x ½“ tapes, thus increasing productivity & quality. Multi Tape Laying Head (MTLH) Technical Features • Flexibility in tape width and number of tapes • Individual control of multiple tapes • Usage of diode laser or VCSEL • Integration on industrial robot or CNC/gantry control of choice Sectorial Applications Sheet production or local reinforcement in: • Hybrid structures (metal reinforcement) • Preform or laminate production • Reinforcement of injection molded parts www.communionproject.eu FOR MORE INFORMATION CONTACT US: AFPT GmbH sales@afpt.de; www.afpt.de +49 6747 950 185 0 Trinkbornstraße 10 56281 Dörth, Germany This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 680567. The dissemination of results herein reflects only the author’s view and the Commission is not responsible for any use that may be made of the information it contains | poster |
Daniele Finazzia,b, Ruben Sevenoisa,b, Wim Van Paepegema a Department of Materials, Textiles and Chemical Engineering, Ghent University, Technologiepark 46, 9052 Zwijnaarde, Belgium b SIM M3 Program, Technologiepark 48, 9052 Zwijnaarde, Belgium The partners of ProPeL M3 research project, coordinated by Siemens (Siemens Digital Industries Software, Belgium), gratefully acknowledge the support of SIM (Strategic Initiative Materials in Flanders) and VLAIO (Flemish government agency Flanders Innovation & Entrepreneurship). ProPeL – PROCESS AND PERFORMANCE SIMULATION OF LIGHTWEIGHT STRUCTURES M3-Project Characterisation of short fibre composites for automotive applications injection THERMAL + MECHANICAL LOADS (proximity to engine, exhaust,…) SHELL SHELL CORE 200 µm “sandwich” microstructure: - SHELL (~90%): fibres aligned with injection direction - CORE (~10%): fibres at ~90° to injection direction MATERIAL APPLICATION Short fibre Glass/PA6 (injection moulding) Automotive parts SYNC CALIB. digital image correlation (DIC) infrared (IR) Self-heating in pure PA6? Self-heating in Glass/PA6? RESEARCH QUESTIONS METHOD (LOCAL) PLASTIC DEFORMATION (LOCAL) DEFORMATION RATE SELF- HEATING 𝜀 ሶ𝜀 𝑇 ሶ𝜀≥ሶ𝜀𝑐𝑟𝑖𝑡 Full-field strain and temperature measurements Strain Strain rate Temperature Tensile tests at room temperature 1. 2. Thermomechanical coupling CHALLENGES Thermoplastic PA6 matrix ENVIRONMENTAL CONDITIONS (temperature, humidity) PLASTIC DEFORMATION HEAT GENERATION ⇒ HEAT GENERATION RATE HEAT LOSS RATE SELF- HEATING ⇒ > 1.E+02 1.E+03 1.E+04 -100 -50 0 50 100 150 200 Temperature Modulus [MPa] 𝑇𝑔 ⇕ 0.36 mm/min ⇕ 36 mm/min ⇕ 360 mm/min x 𝑇 𝜀 ሶ𝜀 humidity decreases transition temperature temperature decreases properties x y z ⇕ 360 mm/min Effect of test speed (same displacement = 52.4 mm) PA6 (50%RH) GLASS/PA6 (50%RH) • Limited, local plastic deformation • Strain rate field not homogeneous • Negligible self-heating, regardless of test speed main fibre orientation thickness cross-section 𝜀 ሶ𝜀 𝑇 • Strain rate field not homogeneous • Temperature field matches strain rate field • Self-heating depending on test speed ⇕ 36 mm/min 90° x ⇕ 0.36 mm/min ⇕ 36 mm/min ⇕ 360 mm/min max +1°C max +4°C max +2°C Effect of test speed (frame before breakage) α 90° 45° 0° PA6 (unfilled) PA6 (unfilled) Polymer matrix composites have been used extensively in the automotive industry, thanks to a unique combination of high performance and light weight. Thermoplastic composites offer advantages in terms of recyclability and cost reduction compared to traditional thermoset composites. However, they are more sensitive to operating conditions. Understanding their coupled thermo-mechanical behaviour is essential to exploiting the full range of applications. I will be happy to discuss with you! Questions? Daniele.Finazzi@ugent.be Daniele Finazzi Test specimens | poster |
Data Output Type 1_Experimental Level. Each evaluation question will have ONE response per experiment, making a fixed total of questions equivilant to the number experiments Category Study Quality Evaluation Question Evaluation Result Test compound and controls Is the chemical name, ID, or CAS number of the test compound (s) provided? Fulfilled Test compound and controls Is the purity of the test compound stated or able to be determind by the information provided? Fulfilled Test compound and controls Is the solubility of test chemicals in the assay system described? Fulfilled Test compound and controls Negative, untreated or vehicle control was included? Fulfilled Test compound and controls Concentration of vehicle was provided? Fulfilled Test compound and controls It was stated that a reference compound or positive control was included? Fulfilled Test compound and controls Information on assay reagents (Product name, supplier and lot) was provided? Fulfilled Total 7 Test System The tests and/or methods used were sufficiently described to allow for evaluation of reliability of results? Fulfilled Test System Conditions (Inclubation temperature, humidity, CO2 concentration, etc.) was described? Fulfilled Test System The androgen receptor source and characteristics(recombinant, native, etc. was described? Not fulfilled Test System The cell system was described? Fulfilled Test System The number of cell passages for the cell line used and the number of cells (density) used during the treatment was described? Not fulfilled Test System The composition of media (use of serum, antibiotics, etc.) was described? Fulfilled Test System The species in which the cell line/test system originiated from is stated or able to be determind by description provided? Fulfilled Test System The test system (cell line/tissue/etc., whole-cell vs. cell-free) was described? Partially fulfilled Test System Were the methods either described in detail or in another publication to which a clear reference is made? Fulfilled Total 9 Funding and competing interests The funding sources for the study were stated? Fulfilled Funding and competing interests Any competing interests were disclosed or it was explicitly stated that the authors did not have any competing interests. Fulfilled Total 2 Administration of test compound Duration of treatment period was provided? Fulfilled Data Output Type 2_Outcome Level. Each evaluation question will have ONE response per experiment-chemical, making a variable total of questions per relevant experiment. Category Evaluation criteria Evaluation Result Administration of test compound It was stated that the effect of the test compound on cytotoxicity was measured? Fulfilled Administration of test compound The administered dose levels or concentration of treatment chemical was stated? Fulfilled Administration of test compound Were all test chemicals tested over a multiple concentrations? Fulfilled Administration of test compound The number of replicates per dose/concentration used or number of times the experiment was repeated was stated? Fulfilled Total 5 Data collection and analysis Acceptability and data interpretation criteria were provided? Fulfilled Data collection and analysis Do the author or reviewer report any concerns with the data reported? Fulfilled Data collection and analysis Measures of variability between replicates of a treatment group is reported (e.g. SD, SE, %CV, 95% CI, etc.)? Not applicable Data collection and analysis The time points for data collection were stated? Fulfilled Total 4 Background Literature Searching & Screening Development of a Curated, Cross-Species Androgen Receptor Database aU.S. EPA, ORD/CCTE/SCDCD, Duluth, Minnesota; bU.S. EPA, OCSPP/OPP, Washington, DC; cU.S. EPA, ORD/CCTE/GLTED, Duluth, Minnesota Sara M.F. Vliet a, Kristan J. Markey b, Scott G. Lynn b, Carlie A. LaLone c • The US Environmental Protection Agency (EPA) is tasked with assessing chemicals for their potential to adversely im | poster |
Raw LC Cleaned LC Iterative prewhitening PU Learning Smoothed LC P: Known Hybrids U: A/F Stars PU Classifier 1.0015 1.001 0 1.00 05 1.0000 0.9995 0.999 0 0.99 85 0.9980 Normalized Flux 1.0015 1.0010 1.0005 1.0000 0.9995 0.9990 0.9985 Final LC Smoothed LC Normalized Flux Positive Unlabelled Learning to Discover Hybrid Pulsating Stars in the TESS Catalogue Mykyta Kliapets (1), Pablo Huijse Heise (1), Andrew Tkachenko (1), Conny Aerts (1, 2, 3) (1) Institute of Astronomy, KU Leuven, Celestijnenlaan 200D, 3001, Leuven, Belgium (2) Department of Astrophysics, IMAPP, Radboud University Nijmegen, PO Box 9010, 6500 GL Nijmegen, The Netherlands (3) Max Planck Institute for Astronomy, Königstuhl 17, 69117 Heidelberg, Germany Correspondence email: nik.kliapets@gmail.com Problem Statement Data: TESS Light Curves (LCs) Methodology Results & Future Work δ Sct / γ Dor hybrid pulsating stars oscillating in both p- and g-modes are crucial for stella r astrophysics, yet not many of them are known. Large volumes of astronomical surveys (Kepler, TESS) make manual search impractical. Machine learning can help increase the available pool of hybrids with automated detection b y leveraging known ones. Known hybrids: 5,017 LCs of 522 known hybrid pulsators from 3 catalogues: Bowman et al (2016) , Li et al (2020), Skarka et al (2022). 1. Unlabelled stars: 122,137 LCs of A/F class stars from TESS Sectors 27 and 40 (Kunimoto et al 2021). 2. Labelled non-hybrids: 2,005 LCs of variable stars in 6 variability classes (Audenaert et al 2021). 3. Some hidden hybrids receive lower probabilities due to noisy data, requiring a cleaner training set (manual inspection of labelled LCs). Sources: Bowman, DM. et al. (2016). “Amplitude modulation in δ Sct stars: statistics from an ensemble study of Kepler targets”. In: Monthly Notices of the Royal Astronomical Society 460.2, pp. 1970–1989. Li, G. et al. (2020). “Gravity-mode period spacings and near-core rotation rates of 611 γ Doradus stars with Kepler”. In: Monthly Notices of the Royal Astronomical Society 491.3, pp. 3586–3605. Skarka, M. et al. (2022). “Periodic variable AF spectral type stars in the northern TESS continuous viewing zone-I. Identification and classification”. In: Astronomy & Astrophysics 666, A142. Kunimoto, M. et al. (2021). “Quick-look pipeline lightcurves for 9.1 million stars observed over the first year of the TESS Extended Mission”. In: Research Notes of the AAS 5.10, p. 234. Audenaert, J. et al. (2021). “TESS data for asteroseismology (T’DA) stellar variability classification pipeline: setup and application to the Kepler Q9 data”. In: The Astronomical Journal 162.5, p. 209. Bekker, J. and Davis, J. (2020). “Learning from positive and unlabeled data: a survey”. In: Machine Learning 109.4, pp. 719–760. New hybrid candidates: 112 LCs from TESS Sectors 27 and 40 with probabilities in [0.98, 1]. Acknowledgement: This Master’s Thesis research was funded with the 2023 Kavli Scholarship in machine learning for astrophysics, given by the Kavli Foundation. Each TESS LC is a separate training example. Using TESS quality flags and removing outliers. Subtracting the moving average to remove instrumental trend. Extracting up to 5 periods in both p- and g-mode regimes with an SNR check. Bagging ensemble outputs a probability of each unlabelled LC being a hybrid pulsator. We are only using extended mission data. Hundreds of millions of stars observed by space telescopes TESS Sectors 27 & 40. Remaining TESS Sectors (and Kepler data) contain hybrid pulsators and other variable phenomena waiting to be detected with PU Learning. 350 300 250 200 150 100 50 0 0 10 60 70 Periodogram p-mode g-mode 20 30 40 50 Frequency [1/d] Power [ppm] 1200 1000 800 600 400 200 0 0 10 20 30 40 Frequency [1/d] 50 Periodogram p-mode g-mode 60 70 Power [ppm] 1.0 0.8 2770 2775 2780 2790 2795 2785 Normalized Flux 0.9 0.7 0.6 Time [d] 2770 2775 2780 2790 2795 2785 Time [d] 2770 2775 2780 2790 2795 2785 Time [d] 10^4 10^3 10^2 10^1 10^0 0 | poster |
Contents Literaturverwaltung – Sachliche Erschliessung von Aufsatznachweisen1 Abb. 1 Die Abbildung zeigt die Startseite von Contents Literaturverwaltung. Ganz unten sind die geladenen Dateien als Webformulare erkennbar. Nach Eingabe von covid als Suchbegriff werden im linken Fenster 9455 Treffer angezeigt, die allerdings auch zahlreiche Dubletten enthalten. Ganz unten in der Trefferliste befindet sich der Eintrag Angezeigte Nachweise nach Datei: Nach dessen Anklicken wird rechts ein Menü geöffnet, aus dem Sie die Datei wählen, nach der die Treffer transportiert werden sollen. Hier wird die noch leere Datei 8 gewählt. Durch Klick auf den Button wird der Transfer gestartet. Nach dem automatischen Reload wird im nächsten Schritt die Datei 8 geladen. Nach Klick auf Zeitschriften A-Z Anzeigen werden in wenigen Sekunden rechts alle Zeitschriftentitel angezeigt, die in der Datei enthalten sind. Schliesslich werden über den Schalter Alle Themen in den Aufsatznachweisen links sofort alle nachgewiesenen Themen angezeigt, also alle Themen, die für Aufsatznachweise zum Begriff covid nachweisbar sind. Abb. 2 Anzeige der ermittelten Zeitschriftentitel und Themen Diese Demonstration lässt sich nur in der lokal installierten Version von Contents Literaturverwaltung mit dem Internet Explorer nachvollziehen, in der auch die Speicherfunktion möglich ist2. Contents Literaturverwaltung besteht aus 9 austauschbaren und erweiterbaren Dateien, von denen hier die Dateien 8 und 9 ohne Inhalt sind. Die übrigen Dateien sind mit Aufsatznachweisen aus allen möglichen Fachgebieten gefüllt. Man kann die Inhalte löschen, mit neuen Inhalten aus einer Suchfunktion wie hier oder über ein Importformular aus auswärtigen Datenbanken füllen. Näheres dazu siehe die beiden Beiträge in Zenodo zu Contents Literaturverwaltung: https://zenodo.org/record/3968587 https://zenodo.org/record/4319894 ______________________________________________________________________________________ Autor: Hans Hehl, Regensburg Webseite:http://www.multisuchsystem.de/ mailto:hanshehl@t-online.de 1 Die Internetversion http://www.multisuchsystem.de/ContentsLit/contentsLit2.html enthielt zuletzt einen gravierenden Fehler für die Aufsatzsuche, der jetzt behoben ist! 2 Die lokale Version können Sie über http://www.multisuchsystem.de/ContentsLit/litzip.zip herunterladen! | poster |
The N-terminal MADA motif in the CC-NLR immune receptors is functionally conserved across distantly related plant species ●Hiroaki Adachi1, Mauricio Contreras1, Adeline Harant1, Chih-hang Wu1, Lida Derevnina1, Toshiyuki Sakai1, Cian Duggan2, Eleonora Moratto2, Tolga O Bozkurt2, Abbas Maqbool1, Joe Win1, Sophien Kamoun1 1The Sainsbury Laboratory, University of East Anglia, Norwich Research Park, Norwich NR4 7UH, UK. 2Imperial College London, Department of Life Sciences, London, UK. 1. Plant CC-NLRs form resistosome “death switch” 9. ACKNOWLEDGMENTS Model of NLR network for effector recognition. NRC, NLR required for cell death. modified from Wu et al. (2017) PNAS Wang et al. (2019) Science 2. NLRs form a receptor network composed of functionally specialized “sensor” and “helper” NLRs In vitro transposon insertion Truncation library in Agrobacterium Functional validation in N. benthamiana Premature STOP codons NRC4DV MuA D478V V 0 100 200 300 400 500 600 700 800 900 HR - HR + 1 145 504 881 9 CC NB-ARC LRR Amino acid position 3. Transposon-based truncation mutagenesis reveals 29 amino-acid region sufficient for NRC4-mediated cell death NRC41-29-YFP NRC4DV-YFP NRC4WT-YFP YFP TRIBE-MCL LRR NB-ARC CC 0 50 100 150 200 250 Number of proteins 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 59 RPM1, MLA10, Sr33, Sr50, Pik-1, Pik-2, RGA4, RGA5 Hero, Mi1.2, Rpi-blb2, Sw-5b R1 RPS5 Bs2 Prf Gpa2, Rx ADR1 NRG1 N-terminal domain tribes NRC2, NRC3, NRC4, ZAR1, RPP8, RPP13, R2, Rpi-vnt1 R3a Dicot Monocot 4. The MADA motif is conserved at the N-terminus of NRC4 and ZAR1 Dataset: 988 CC/CCR-NLRs from Arabidopsis, sugar beet, tomato, N. benthamiana, rice and barley. NRC4 MADA motif 1 21 0 1 2 3 4 bits 1 E R A L VM 2 G Y T L VA 3 A N S T G ED 4 I G T V E SA 5 G T I A F L V 6 M T LIV 7 D K G A E T NS 8 N T Y P S K L VF 9 S F V G L A 10 A T LIV 11 D G N S KQE 12 L Q A R S I W NK 13 V Y T A IL 14 Q S A M K L W G 15 H T K G E S N Q D 16 Q T W Y I V FL 17 E M V I AL 18 A E R T L V S I 19 K N S Y H R D E Q 20 H K Q NE 21 W G Y C I S A V 1 MADAVVNFLVENLLQLLTDNV 21 1 MVDAVVTVFLEKTLNILEEKG 21 NRC4 ZAR1 LRR NB-ARC CC NRC41-29 NRC4DV A B A, Clustering N-terminal domain of CC-NLRs by Tribe-MCL analysis. B, The consensus sequence pattern of the MADA motif identified by MEME. NRC-S without NTD NRC-H family NRC-S with NTD 0.1 NRC superclade Mi-1.2 Rpi-blb2 Hero Sw5b R1 Prf Bs2 Gpa2 Rx NRC4 NRC2 NRC3 Tree scale: 0.2 ZAR1 RPP13 R2 RPP8 RPi-vnt1 Pik-2 Tree scale: 0.2 Other NLRs MADA-CC-NLRs Bootstrap value > 0.7 6. NRC sensors do not have the MADA motif NRC-H: NRC helpers, NRC-S: NRC dependent sensors, NTD: N-terminal extension domain 0 5 10 15 20 25 30 35 40 Rice Barley Arabidposis Sugar beet Tomato N. benthamiana 0 5 10 15 20 25 30 35 40 Rice Barley Arabidposis Sugar beet Tomato N. benthamiana Frequency (%) MADA-CC-NLR MADAL-CC-NLR 15/371 4/229 25/72 14/88 32/133 14/81 72/371 36/229 1/72 4/88 5/133 13/81 5. The MADA motif is present in ~20% of CC-NLRs MADA HMM LRR NB-ARC CC Dataset: 988 CC/CCR-NLRs from Arabidopsis, sugar beet, tomato, N. benthamiana, rice and barley. Occurrence of MADA-CC-NLRs in monocots and dicots. MADAL-CC-NLR: MADA-like CC-NLR Pathogen Effector(s) Singleton NLR NLR network NLR pair Sensor NLR Helper NLR Time Specialization Diversification ▶ Degenerated MADA motif ▶ N-terminal domain integration ▶ Conserved MADA motif ▶ Conserved MADA position Sensor NLR Helper NLR Convergent downstream Hypersensitive cell death and disease resistance AvrBs2 CP AvrPto/ AvrPtoB AVR1 NSm Avr8 Avrblb2 Unknown protein Unknown protein RBP-1 NRC2 NRC3 NRC4 Gpa2 Rx Bs2 Prf R1 Sw5b R8 Rpi-blb2 Mi A B C A, Overview of the strategy for transposon-based C-terminal random truncation of NRC4 proteins. B, NRC41-29::Mu-STOP triggers cell death in N. benthamiana leaves. C, NRC41-29-YFP induces cell death in N. benthamiana leaves. The phylogenetic trees of the 988 CC-NLRs (Left) and the NRC superclade (right). NRC4WT NRC4DV NRC21-17 | poster |
Stakeholder bei Open Access Publikationen in den Geistes- wissenschaften Open-Access- Projekte Repositorien Scholar-led Verlage Open-Access- Dienstleister Autor:innen Großverlage Universitäts- verlage Kleine/mittlere Fachverlage Infrastruktur- Plattformen Fachgesell- schaften Forschende Lehrende Gesellschaft und Wirtschaft Medien Stiftungen NGOs Öffentliche Forschungs- förderung Politik Leser:innen Verlage Weitere Akteur:innen Was passiert im Forschungsprojekt AuROA? Wir entwickeln Musterverträge und arbeiten für mehr Kooperation und Standardisierung bei Open- Access-Buchpublikationen. Stakeholder-Workshops stellen sicher, dass die Perspektiven aller am Publikationsablauf beteiligten Akteur:innen in die Musterverträge eingehen. Ein aufgabenzentrierter Leistungskatalog über die Bedarfe und Optionen bei einer Open-Access- Publikation soll den Ablauf einer Veröffentlichung transparenter und einfacher gestalten. Kernziel des Verbundprojekts AuROA ist die Entwicklung von rechtssicheren, vielfältig einsetzbaren Musterverträgen. Diese decken Themen ab wie wissenschaftliche sowie technische Qualitätssicherung, vereinbarte Dienstleistungen, Nutzungsrechte und freie Lizenzen. Die Verträge sollen den hohen Standards wissenschaftlicher Publikationen einen rechtssicheren Rahmen geben und Unsicherheiten sowie Vorbehalte gegenüber Open Access bei allen Beteiligten abbauen. Universitäts- bibliotheken Weitere Rollen von Autor:innen (Teil-)Funktionen von Universitätsbibliotheken „Wo sehen Sie Handlungsbedarf?“ Befragung Stakeholder-Workshop 01.07.2021 (n=14, Mehrfachnennung möglich) Privatwirtschaftlich Öffentlich finanziert Unterschiedlich finanziert Wissenschaft www.projekt-auroa.de Projektlaufzeit: Februar 2021 – Januar 2023 Yuliya Fadeeva, Universität Duisburg-Essen yuliya.fadeeva@uni-due.de Matthias Laugwitz, IST-Hochschule für Management mlaugwitz@ist-hochschule.de Veröffentlicht unter CC BY 4.0 | poster |
INTRODUCTION NUMERICAL EXPERIMENTS RESULTS DISCUSSION AND CONCLUSION A Geodynamic Modeling Investigation of Plume-Lithosphere Interactions Beneath the East African Rift Tahiry Rajaonarison, Sarah Stamps, John Naliboff, Andrew Nyblade Virginia Tech (dstamps@vt.edu), New Mexico Tech, Penn State University 1 1 3 1 2 REFERENCES Alejano, L. R., and A. Bobet. Drucker–prager criterion (2012), in The ISRM Suggested Methods for Rock Characterization, Testing and Monitoring: 2007-2014, pp. 247–252, Springer . Amante, C., & Eakins, B. W. ETOPO1 arc-minute global relief model: procedures, data sources and analysis (2009). Arndt D. , W. Bangerth, T. C. Clevenger, D. Davydov, M. Fehling, D. Garcia-Sanchez, G. Harper, T. Heister, L. Heltai, M. Kronbichler, R. M. Kynch, M. Maier, J.-P. Pelteret, B. Turcksin, D. Wells (2019), The deal.II Library, Version 9.1, Journal of Numerical Mathematics, Volume 27, Issue 4, Pages 203-213. Bagley, B., and A. A. Nyblade (2013), Seismic anisotropy in eastern africa, mantle flow, and the african superplume, Geophysical Research Letters , 40 (8), 1500–1505, doi:10.1002/grl.50315. Bangerth, W., T. Heister, et al. (2015), ASPECT: Advanced solver for problems in Earth’s convection, Computational Infrastructure for Geodynamics. Bangerth, W., J. Dannberg, R. Gassmoeller, T. Heister, et al. ASPECT v2.2.0 [software] (2019). Bassin, Chantal (200), "The current limits of resolution for surface wave tomography in North America." EOS Trans. AGU. 81: Fall Meet. Suppl., Abstract. Chapman, D. (1986) Thermal gradients in the continental crust, Geological Society, London, Special Publications , 24 (1), 63–70. cal Research: Solid Earth, 86(B4), 2825-2852. Kronbichler, M., T. Heister, and W. Bangerth (2012), High accuracy mantle convection simulation through modern numerical methods, Geophysical Journal International, 191(1), 12–29, doi: 10.1111/j.1365-246X.2012.05609.x. 2 3 GOVERNING EQUATIONS MODEL ASSUMPTIONS AND CHARACTERISTIC WORK IN PROGRESS TESTING THE ROLE OF MULTIPLE PLUMES OR SUPERPLUME Coblentz, D. D., and M. Sandiford (1994), Tectonic stresses in the african plate: Constraints on the ambient lithospheric stress state, Geology , 22 (9), 831–834Dziewonski, A. M., Chou, T. A., & Woodhouse, J. H. (1981), Determination of earthquake source parameters from waveform data for studies of global and regional seismicity. Journal of Geophysical Research: Solid Earth, 86(B4), 2825-2852. Edwards, M. O. 1989, "Global gridded elevation and bathymetry (ETOPO5)." Digital raster data on a 5. Ekström, G., M. Nettles, and A. Dziewonski (2012), The global cmt project 2004–2010: Centroid-moment tensors for 13,017 earthquakes, Physics of the Earth and Planetary Interiors , 200, 1–9. Emry, E. L., Shen, Y., Nyblade, A. A., Flinders, A., & Bao, X. (2019), Upper mantle earth structure in Africa from full‐wave ambient noise tomography. Geochemistry, Geophysics, Geosystems, 20(1), 120-147, doi:10.1029/2018GC007Glerum, A., Brune, S., Stamps, D. S., & Strecker, M. R. (2020), Victoria continental microplate dynamics controlled by the lithospheric strength distribution of the East African Rift. Nature Communications, 11(1), 1-15. Kronbichler, M., T. Heister, and W. Bangerth (2012), High accuracy mantle convection simulation through modern numerical methods, Geophysical Journal International, 191(1), 12–29, doi: 10.1111/j.1365-246X.2012.05609.x. Pasyanos, M. E. (2013), A lithospheric attenuation model of North America. Bulletin of the Seismological Society of America, 103(6), 3321-3333, doi:10.1785/0120130122. Saria, E., E. Calais, D. Stamps, D. Delvaux, and C. Hartnady. Present-day kinematics of the east african rift, Journal of Geophysical Research: Solid Earth, 119(4), 3584–3600 (2014). Stamps, D. S., Saria, E., & Kreemer, C. A geodetic strain rate model for the East African Rift System. Scientific Reports, 8(1), 1-8 (2018). Stamps, D., L. Flesch, E. Calais, and A. Ghosh. Current kinematics and dynamics of africa and the east african rift system, Jou | poster |
BURDEN OF TUBERCULOSIS IN MALAYSIA: AN OVERVIEW FOR 2015 Nur Hamizah Nasaruddin1, Shubash Shander Ganapathy1, Mohd Azahadi Omar2, Mohamad Fuad Mohamad Anuar1, LeeAnn Tan1, Nazirah Alias1 1INSTITUTE FOR PUBLIC HEALTH, NATIONAL INSTITUTES OF HEALTH, SHAH ALAM, MALAYSIA 2SECTOR FOR BIOSTATISTICS AND DATA REPOSITORY, NATIONAL INSTITUTES OF HEALTH, SHAH ALAM, MALAYSIA P-10 NMRR-18-609-41165 INTRODUCTION RESULTS Tuberculosis caused in Malaysia for the year 2015. MATERIALS AND METHODS The calculation of burden of disease in terms of DALY was done using the methodology used in the Global Burden of Disease Study2. The DALYs for tuberculosis were calculated by summing the Years of Life Lost (YLL) with the Years Lived with Disability (YLD). The YLLs were calculated using the mortality and life expectancy data obtained from Malaysia’s Department of Statistics. The YLDs were produced using prevalence derived from DISMOD-II software based on incidence data provided by Malaysia’s disease notification system. YLL YLD One DALY can be thought of as ONE LOST YEAR OF HEALTHY LIFE for the entire population2. DALY DALY is a health gap2. Tuberculosis is a preventable disease but still remains a public health concern. This study aims to describe Malaysia’s burden of tuberculosis for the year 2015 in terms of Disability Adjusted Life Years (DALYs). The World Health Organization (WHO) estimated that nearly ONE QUARTER OF THE WORLD population are at risk of progression to tuberculosis disease1. YLL (71.2%) YLD (28.8) (mortality component) (morbidity component) The MORTALITY COMPONENT was higher than the morbidity component. The RATE of tuberculosis burden increases with age and was highest among those AGED 65 YEARS AND OLDER. 0-14 15–24 25-54 55-64 65+ 419 336 208 68 10 AGE GROUP (YEARS) DALY PER 100,000 POPULATION The reduction of tuberculosis morbidity and mortality among MALES can potentially reduce a large number of tuberculosis burden in Malaysia. Stronger approaches towards lowering the number of non-communicable diseases could help lessen Malaysian ELDERLY’s risk of tuberculosis progression and deaths. CONCLUSION The authors would like to thank the Director General of Health Malaysia for his permission to publish this article. REFERENCES 1. World Health Organization. Global tuberculosis report 2019. 2. Colin M et al. National burden of disease studies: A practical guide. Global program on evidence for health policy. Geneva: World Health Organization. 2001. 3. Suchunya A et al. Decreasing the burden of infectious disease in Thailand. The Lancet 2013; 381 S11. 4. Pamela Nogueira Silva V et al. Burden of tuberculosis trends in a Brazilian southern state. Rev bras epidemiol 2018. 5. Horton KC et al. Sex differences in tuberculosis burden and notifications in low- and middle-income countries: A systematic review and meta- analysis. PLoS Med 2016; 13 1-23. Population aged between 25- 54 YEARS OLD caused the highest tuberculosis burden. AGE GROUP (YEARS) % OF DALY 1.7% 57.4% 16.2% 16.0% 8.7% 65 + 55 - 64 25 - 54 15 – 24 0 - 14 MALES contributed more DALYs compared to females. 63.3% 30.7% 4 7 , 7 3 6 D A L Y s Malaysia’s burden of tuberculosis accounted for 0.9% of the overall DALYs in 2015, which is much lower compared to those observed in other countries such as Thailand (1.4% of overall DALYs in 2009) and Brazil (2% of overall DALYs in 2010)3,4. Timely detection and prompt treatment should be emphasized to prevent early deaths and subsequently reduce the high tuberculosis mortality burden. Reducing the tuberculosis burden among males could be done most efficiently by improving access for tuberculosis care for males, providing counseling sessions as well as lost of wages compensation5. Mass media campaigns on tuberculosis awareness programs, targeting age-specific groups could help reach those within the high tuberculosis burden categories. DISCUSSION | poster |
Download the poster windeurope.org/tech2021 #WindTech21 Power curve documents contain highly sensitive data - access to which should be carefully managed for good commercial and technical reasons. This appears to conflict with the trend toward digitalization, especially seamless data exchange, which enables reduction in: - time-to-market for new wind turbines, - time-to-financial-close for new wind farms, and - workflow friction between internal and external teams. These seemingly opposed considerations can be reconciled (and accesss control enhanced) by adopting a so-called schema - a public description of the data structure – and (pending appropriate access and permissions) delivering power curve data to other stakeholders which conforms to the schema. We here introduce a schema for power curve data, discussing downstream applications and tools together with lessons learned over two years of trials. The resulting schema handles complexities including - multiple operating modes, - multi-dimensional parameter (eg air density, turbulence, wind speed), - different ratings and cut in/out criteria on a per-mode basis - provision of values as absolute or coefficient (P/CP and T/CT) - and many more. The schema has been proven versatile and useful for over two years in a production system for array design, where it has been used to describe >30 power curves over 8 major turbine manufacturers. There are some known limitations (particularly re. certification metadata) and more may emerge - evolution will continue and collaboration is very welcome. Abstract Results Objectives Benefits and downstream tools Method Working with industry partners, we initially gathered 20+ turbine power curve data sheets to which we had been permitted access. In order to automate design processes using them, a consistent data structure was required. Items in the data sheets were evaluated as being common (“all turbine power curves have this”), uncommon (“some turbine power curves have this”) and extraordinary (“rarely seen”). Data was extracted using a mixture of manual and OCR approaches, then iteratively refined toward a common, versatile pattern expressed using the JSONSchema specification. The array ordering was optimized to default to efficient C-style memory access alignment for typical usage patterns in downstream applications. Subsequently, data sheets from many more turbines (as required over a period of two years) were extracted into a compliant form, with minor evolutions of the schema to encompass subtleties encountered. Powerful Power Curves: A production-proven, open-source schema for wind turbine power curves Tom Clark, Octue PO.208 WE’RE RUNNING THE “72 Hours at WindEurope” CHALLENGE – FIND US IN THE HALL! Replace with QR code Replace with QR code We here introduce an open-source JSONSchema to describe a wind turbine power curve and its associated metadata. We will show some downstream tools uses and benefits of the approach, including automated reporting, human-based QC, and generation of web forms for data entry. Finally, the talk will cover opportunities for collaboration and touch on some limitations and areas in which the schema should continue to evolve. See the schema here >>> In a scientific/engineering environment, adopting a JSONSchema allows everybody to get instantly on the same page about what data actually *IS*. The practice: - Dramatically reduces the 45% of working time that typical engineers/scientists spend preparing data (Anaconda, 2020) - Helps teams cross “the technology chasm” to deliver business outcomes, like accelerated time-to-close, by allowing the ecosystem of downstream automations and tools to develop (Gartner, 2019) - Fosters greater control and auditability of data exchange/access (through strict permitting workflows combined with automation) than manually emailing sensitive PDF documents to stakeholders As an example of a useful downstream tool, web forms can be autogenerated for data entry, as can interactiv | poster |
STARTUP LONG-TERM AGROFORESTRY RESEARCH PLOT Walnut in silvoarable alley cropping system © Inagro OBJECTIVE Long-term research • Tree-crop interaction & yield • Ecosystem services (soil, water, biodiversity) • Practical feasibility • Profitability in Flemish agricultural context Demonstration • Need for good-example • Share lessons learned on implementing, managing and functioning of an agroforestry system • Main target group: farmers FIRST RESULTS Yield per ha and quality of leek is unaffected • Average yield of 61 tons per ha is comparable to other fields in region • No differences in terms of distance to tree row • Visual inspections confirm good quality and health Design is based on practical feasibility, profitability and reproducibility in the Flemish agricultural context. Authors: Willem Van Colen1, Thomas Van Loo1, Dieter Depraetere1 1 Inagro vzw, Belgium, willem.vancolen@inagro.be This poster is based upon work from the project REFOREST that has received funding from the European Union’s Horizon Europe Programme under Grant Agreement Nr. 101060635. Startup and first results of a long-term practice-oriented agroforestry research field in Flanders, Belgium https://agroreforest.eu Plot design – ‘keep it simple’ • Silvoarable alley cropping system • Conventional farming system • Tree: walnut (Juglans regia ‘Broadview’) • Tree row: perennial flower mix attracting beneficial insects • Intercrop: 6 year crop rotation with arable crops (maize, potatoes, winter cereals, field beans) and vegetables (leeks, carrots, cabbages, celereac) -> In cooperation with local farmers • Mixed hedge: windbreak and habitat for insects and birds Long-term monitoring Improve tailored advice & Increase adoption in Flanders The sampling distance of 10,5 m is considered as the reference situation for now. The number of transects differs per parameter. For some parameters not all distances are included in the transects due to practical considerations. Intercrops • Yield, quality, diseases REGIONAL CHALLENGE Drone picture of the recently established agroforestry research and demonstration plot located on the trial fields of Inagro, West-Flanders. This plot is one of the seven REFOREST living labs across Europe. Trees • Yield, growth, diseases Microclimate • Light (pyranometer) • Rain, wind, temperature & humidity (weather stations) Soil • Chemical soil analysis (0-30 cm) • Organic carbon (0 – 90 cm) • Moisture (20 cm + 60 cm) • Compaction (penetrologger) • Bulk density (Kopecky rings) • Nematods (under development) • Bacteria & fungi (PLFA analysis) • Earthworms Biodiversity • Overwintering soil invertebrates (soil incubations) • Moths (LED buckets) • Surface dwelling arthropodes (pitfall traps) • Flying arthropodes (window traps) • Birds and bats (Audiomoth) Fertile sandy loam soils make the central part of West-Flanders suitable for intensive, highly productive and profitable vegetable growing. As a result, agricultural land prices in West-Flanders are amongst the highest in Europe. Walnuts as high value product. Late-leafing and open crown reduce competition for light with intercrops. Trees need to produce and eventually compensate for relatively high loss of income by loss of cropping area, while impact on yield of intercrops needs to be limited. Financial – ins and outs MONITORING TRANSECTS Establishment costs Loss of cropping area is decisive in early stage • Tree rows and hedge reduce cropping area by 11% • Harvest machinery requires additional uncultivated strips -> 5% extra loss of cropping area • 84% of the plot was cultivated with leek, resulting in a production loss of 13,6 ton = loss of income ± € 2.700 Leeks in (young) agroforestry Impact of tree rows on preparatory soil work and planting of leek is limited WATCH OUR VIDEO! And get inspired… READ MORE? Check our website! STAY UPDATED? Subscribe to our newsletter and be the first to receive future results through our article series ‘Digging Deeper’ ! As an active farmer, you can have you | poster |
Fostering resource integration: EarthCube Resource Registry What is the EarthCube Resource Registry? A database of cyberinfrastructure resources with documentation focused on enabling EarthCube users and developers find, understand, get, and use those resources to increase research productivity Resource focus: applications, reusable code components, ontologies, vocabularies, specifications (extending the GeoCODES dataset registry) Why? • Improve discovery of usable resources • Enable seamless connection from discovery environment to working with the data or software. Some usage scenarios: • Identification of resources • Systematic documentation of resource characteristics • Identify gaps or duplicate resources • Find tools, APIs, or data that can work with a given resource • Support maturity assessment The Registry should: • Help researchers connect multiple data types and resources to address a specific research problem; • Enable developers to learn about components they can reuse to increase development efficiency • Enable discovery of components with a particular functionality, that can be used in an existing research workflow • Provide a platform for resource producers to inform the community about products. • Answer the question: “What has EC produced that is of use to my science?” Workflow Resource Type Matching and Exploration: Resource registry Return associated resources based on type (eg software to to work with that data) Query to registry Resource Discovery UI, with an option to open in software application (1) Notebook to retrieve metadata content and examine resource type (2) Notebook to explore the resource using matched software based on resource typeResource IDResource TypeResource IDs Matched resource Link data and applications Resource Registration Web Form An online form generated using Google Forms to submit resource descriptions. • a series of views o First views are for fields that apply to all resources. o User then identifies the kind of resource they are registering, o Subsequent views are specific to that resource. Required fields are indicated with a red asterisk (*) A submitted resource is assigned an ARK URI identifier, Documentation is stored in the EarthCube registry, made available for browsing and discovery via the SuAVE viewer, and accessible via API. Browse and Search registry content: SuAVE Viewer Resource summaryclick Example controlled pick list First page of registration form Stephen M. Richard, LDEO, Columbia University and US Geoscience Information Network (USGIN); Ilya Zaslavsky, San Diego Supercomputer Center; and Ruth Duerr, Ronin Institute for Independent Scholarship SuAVE viewer for EarthCube resources Resource Registration Form for submitting resources: Viewer for adding information Edit view for modifying the form Resource Registry SPARQL endpoint (username/password sent by email) Documentation on mapping resource descriptions to the registry ontology and JSON-LD serialization. Controlled vocabularies Google Sheet (one tab for each vocabulary) EarthCube Resource Registry Presentation - https://drive.google.com/file/d/1dwIUliAurfFstWRSiY74UBoUSaJYlVvc Links Resource Types Bundled Object Catalog Dataset Document Information Model Interchange Format Interface Platform Repository Service Software Specification UseCase This work was supported by funding from the 2019 ESSO EarthCube Office and the 2020 ECO EarthCube office Example search for resources related to SPARQL | poster |
The envelopes of low-mass stars: the impact of Coulomb effects on stellar oscillations Ana Brito 1),2) & Ilídio Lopes 2) 2) Centro de Astrofísica e Gravitação - CENTRA, Departamento de Física, Instituto Superior Técnico, IST, Universidade de Lisboa - UL, Av. Rovisco Pais 1, 1049-001 Lisboa, Portugal | ilidio.lopes@tecnico.ulisboa.pt 1) Departamento de Matemática, Instituto Superior de Gestão, Av. Marechal Craveiro Lopes, 1700-284, Lisboa, Portugal | anabrito@isg.pt I. Introduction V. Conclusion In this work, we explore the outer layers of stars less massive than the Sun. In particular, we have computed a set of stellar models raging from 0.4 to 0.9 solar masses with the aim at determining the impact on stellar oscillations of two physical processes occurring in the envelopes of these stars. Namely, the partial ionisation of chemical elements and the electrostatic interactions between particles in the outer layers. We find that alongside with partial ionisation, Coulomb effects also impact the acoustic oscillation spectrum. The influence of Coulomb interactions on the sound-speed gradient profile produces a strong oscillatory behaviour with diagnostic potential for the future. We find that, around the value of 0.6 solar masses, the peak/dip in the first adiabatic exponent/acoustic potential corresponding to helium ionisation zones (Fig. 1) vanishes and, consequently, does not produce an oscillatory signature in the seismic diagnostic β(ν). This is thus the reference value, for models with solar metallicity, around which occurs a transition in the characteristics of the oscillatory signal imprinted in the oscillation frequencies by two distinct physical processes. The acoustic spectrum of stars more massive than 0.6 solar masses is mostly impacted by partial ionisation processes, whereas the acoustic spectrum of stars less massive than 0.6 solar masses is predominantly impacted by Coulomb interactions. II. Thermodynamic properties of the turbulent outer regions The behaviour of the first adiabatic The behaviour of the first adiabatic exponent around its monatomic ideal exponent around its monatomic ideal gas value, 5/3, is influenced by two gas value, 5/3, is influenced by two fundamental aspects. First, the increase fundamental aspects. First, the increase of the degree of ionisation decreases of the degree of ionisation decreases the Γ the Γ1 value, causing a known value, causing a known depression in the radial profile of Γ depression in the radial profile of Γ1, , particularly throughout the partial particularly throughout the partial ionisation zones of light elements, ionisation zones of light elements, hydrogen and helium. The second hydrogen and helium. The second aspect that influences the behaviour of aspect that influences the behaviour of the first adiabatic exponent relates to the first adiabatic exponent relates to the electrostatic interactions between the electrostatic interactions between charged particles, known generally as charged particles, known generally as Coulomb effects. Coulomb effects Coulomb effects. Coulomb effects increase the value of Γ increase the value of Γ1 causing it to causing it to become larger than 5/3 in some regions become larger than 5/3 in some regions of the convective zone. Also, the of the convective zone. Also, the acoustic potential is determined by the acoustic potential is determined by the model structure and, therefore, will be model structure and, therefore, will be impacted by physical processes like impacted by physical processes like partial ionisation of atomic species and partial ionisation of atomic species and electrostatic interactions between electrostatic interactions between charged particles. Fig. 1 shows these charged particles. Fig. 1 shows these two profiles for all the models. two profiles for all the models. Fig. 2 The ionic plasma interaction parameter, Γi , as a function of temperature. Also plotted in this figure, with grey colour, is the sound- speed gra | poster |
B.L. Moore, S. Aitken and C.A. Semple MRC Human Genetics Unit, Western General Hospital, Edinburgh EH4 2XU Introduction Strong concordance between cell types Prediction of higher-order structure References ‣ Histone modifications ‣ Histone variants ‣ Transcription factors ‣ Dnase hypersensitivity ‣ DNA methylation ‣ Transcription level What's the relationship between these locus-level features and higher-order chromatin? ben.moore@igmm.ed.ac.uk What determines higher-order chromatin? Identification of significantly divergent regions PC eigenvector value −2 −1 0 1 2 10 MB H1 IMR90 K562 GM06990 GM12878 "Open" "Closed" p53 0 1 2 Atf3 0 1 2 Cebpb 0 1 2 Chd1 0 1 2 Chd2 0 1 2 Cmyc 0 1 2 Ctcf 0 1 2 Egr1 0 1 2 Ezh2 0 1 2 Gabp 0 1 2 J und 0 1 2 Mafk 0 1 2 Max 0 1 2 H2az 0 1 2 H3k27ac 0 1 2 H3k27me3 0 1 2 H3k36me3 0 1 2 H3k4me1 0 1 2 H3k4me2 0 1 2 H3k4me3 0 1 2 H3k79me2 0 1 2 H3k9ac 0 1 2 H3k9me3 0 1 2 H4k20me1 0 1 2 Mxi1 0 1 2 Nrsf 0 1 2 Pol2 0 1 2 P300 0 1 2 Six5 0 1 2 Sp1 0 1 2 Taf1 0 1 2 Tbp 0 1 2 Yy1 0 1 2 Znf143 0.30 0.45 gc 1 2 3 4 Dnase −3 −1 1 0 40 80 120 P300 Chd1 Tbp Max Znf143 Mxi Six5 J unD Chd2 H3k9me3 H3k27me3 H4k20me1 Ezh2 Gabp Yy1 Sp1 Rad21 H3k36me3 H3k4me3 H3k4me2 Pol2 H3k9ac Mean decrease in accuracy 0 50 100 150 200 c−Myc P300 Ezh2 H3k9ac H3k79me2 Cebpb Six5 Chd1 Chd2 H2az H3k27me3 Pol2 Atf3 J unD H3k27ac H3k4me1 Gabp H4k20me1 H3k9me3 Mean decrease in accuracy 0 50 100 150 200 J unD Cebpb MafK Chd1 c−Myc Max H2az Egr1 Ezh2 Chd2 Ctcf Atf3 Gabp Mean decrease in accuracy 0 50 100 150 200 Conclusions: • Higher-order chromatin structure can be accurately modelled using locus-level features. • A strong correlation of chromatin structure between cell types was observed, but the determinants appear to vary greatly. • Future work will look at characterising divergent regions and identifying important variables at these sites. Box 1. Hi-C is a method of producing genome-wide measurements of the frequency that genomic regions interact in the nucleus. Hi-C builds upon existing chromosome capture techniques, but uses high- throughput sequencing to output all-vs-all measurements. See [1] for a detailed description. Recent advances in chromosome capture technology have permitted genome-wide assessment of higher-order chromatin structure in a variety of cell types. This data in conjunction with that produced by the ENCODE consortium offers an unprecedented opportunity to investigate the antecedents of higher-order chromatin structure. To address this question I used an integrative modelling approach, whereby the above input variables are considered as predictors of higher-order structure. Hi-C (see box 1) genome-wide interactions can be reduced to an eigenvector summary metric which captures compartmentalisation of the genome into two broad compartments, "open" and "closed". These have been shown to represent gene dense, transcriptionally active and relatively gene poor, inactive regions respectively [1]. Recently modelling techniques were applied to the prediction of transcription and acheived high accuracy [2] so it was of interest to see if this could be replicated with chromatin structure. The resulting model was then compared across cell types and interrogated to reveal the relative importance of the various predictor variables. An arc diagram with edges joining nodes with higher than average interaction frequency as measured by Hi-C. Edge widths are proportional to the number of pairwise interactions recorded. Nodes are coloured by eigenvector (positive or "open" are light blue) and scaled by absolute eigenvector value. Hi-C interaction matrix derived from H1 hESC [1]. Figure 1. Over-represented pairwise interactions on chromosome 1. A correlogram (A) showing scatterplots, kernel density estimates and Pearson correlation of eigenvectors of 1 MB blocks across 11 chromosomes and 5 cell types, with data coming from 3 different experiments. A line plot (B) shows the actual eigenvectors to scale on their respective chromosomes (8 s | poster |
Changing Horses in Mid-Stream: The New ADS Michael J. Kurtz Harvard-Smithsonian Center for Astrophysics The Smithsonian/NASA Astrophysics Data System (ADS) is the core digital library for astrophysics. It was built in 1992, put on the Internet for public use in 1993, and moved to the WWW in 1994. It was an immediate success, and has dominated astronomers use of their scholarly literature ever since. By the beginning of the 21st century it was clear the ADS was an important part of the scholarly infrastructure of astronomy. This required that it be rebuilt, from the original ad hoc system to more long-‐ term stable, maintainable, robust and extensible one, while keeping the existing service operating 24/7/365. This has been substantially more difficult than we imagined; finally begun in 2007 the new system was released this spring (2018), to run for a year in parallel with the old, Classic system until next spring, when the Classic system will be turned off, after a quarter of a century of use. The project has taken more than a decade of intense work; it required a change in the management structure, and an eventual doubling of the staff (and thus budget). During this time the technological landscape has changed substantially, many promising directions for the development were taken, only to be later abandoned. Additionally many new capabilities became possible, requiring improvements both to the new design, and where feasible, to the old system as well. We hope the new ADS will enable researchers discovery for the next 25 years. The ADS is at ads.harvard.edu A Decade of Effort | poster |
* Diagnosticar la enfermedad antes de tener el primer hijo Ejercer una paternidad informada, sin coacciones Ofrecer las técnicas de reproducción humana asistida que eviten la trasmisión de la enfermedad Identificar y localizar los casos desconocidos Informar de manera adecuada a pacientes y familiares Figura 1: Nuestro modelo de HEXÁGONO PREVENTIVO DE LA PQRAD** *Iconografía de Riñón poliquístico del Biobanco PQRAD del HU Virgen de las Nieves, ibs.GRANADA ** Bravo-Soto JA, Esteban-de-la-Rosa RJ, Morales García AI, García Valverde M, et al. GEEPAD y Asociación Amigos del Riñón Recuperar los casos perdidos para control | poster |
MODERNIZING DATA-DELIVERY TECHNOLOGIES Combining Data-User Feedback with User-Support Expertise for Successful Data Tools And Pivoting when Technology Changes! Digital Data Products: Two Key Questions ➊ What problem(s) need to be solved? ➋ How do users want to solve those problems? Unlocking the potential of data tools requires: understanding user needs (talking directly with data users); leveraging existing user support expertise; the pivoting unapologetically if user demands and tech developments shift. Why This Matters to You Elevate your potential to gather effective user feedback when developing digital data products and data-related services: • When resources or time are in short supply • That goes beyond “textbook” or “Google-search” research approaches used in ideal conditions • To see some cool, recently launched products produced by ICPSR that your patrons may have interest in using Before Starting Definitions User Testing: the process of collecting research data from real users while they are using a digital product whether a prototype or fully launched User: an individual that uses or has the propensity to use a digital product; includes the individuals who actually interact with the product as well as those directing/training users to interact with the product User Support: individuals who assist hundreds of users annually who are interacting with a product whether support is for general questions or to solve problems User Research: The Practicalities Purpose: Observe, log, and analyze user interactions with a product, noting successes, challenges, and failures in order to improve user experience on the front-end and content received in the back-office Challenges: • Finding & recruiting “real” users • Expense $$ and time intensive • Live user research is a lab experience; users often act differently in the wild! • Users represent one experience — their own! Is their experience unique or common — that is the question! Process: At-A-Glance 1st Step Define the problem What is the (user) problem(s) to solve? How will it help the producer of the product (it’s okay to help yourself!)? Hint: Key to success — include user support staff in all phases starting with problem definition. 2nd Step Define the user Who is the primary user? Secondary? Hint: Define demographically, experience levels (substantive, technological, methodological) 3rd Step Test, Research, Build, and, if needed, Pivot • Recruit for testing and reward ($) • Conduct research again and again and again • Invite user support to help interpret research Hint: Digital Products — Be prepared to pivot when new technology arrives (AI changes everything!) Real-life Examples from ICPSR Digital Data Product Releases Product Research Data Ecosystem TurboCurator Problem Depositors not often knowledgeable on creating Findable metadata efficiently Solution ICPSR’s TurboCurator — designed to semi-automate the process Pivot Technology-inspired: AI - ChatGPT Identified three key metadata areas (Title, Description, Key Words) • Depositor inputs general information about the study, dataset, or file • TurboCurator, powered in part by AI, outputs accepted formats for title, description, and controlled key words that depositor can cut/paste to describe the data deposit https://myumi.ch/AZwPe Product Research Data Ecosystem Explore Data Problem A need to “look into” the data to learn more about “what’s in there” before downloading it or analyzing it; make data more Accessible Solution ICPSR’s Explore Data Pivot User-inspired: Users advised against another statistical analysis tool; keep it simple https://myumi.ch/G4Gz1 Product Research Data Ecosystem Researcher Passport Authentication & Authorization System Problem A need for an updated authentication and authorization system to exit ICPSR from password management (increase security) and make access to restricted-use data less cumbersome Solution ICPSR’s Researcher Passport — launching in two phases: • Basic Passport — basic acco | poster |
AlligatorDAmeriq_1a8c ApelleCebusApell_f4b9 ArtibeusPerspici_2a22 AteleAtelesAter_7245 Atele_6717 AutrucheDAfrique_6973 AyeAyeDaubentoni_cb56 BabouinCercopith_a723 BlaireauAGorgeBl_db3a BlaireauEuropeen_618f Bradypus_5eb1 CaracalLynchusCa_639b CasoarACasqueCas_4dab CasoarEmeuJeuneC_aa2f ChacalThosAureus_6fe4 ChatCyclope_e0cd ChatPecheurPrion_bd43 ChauveSourisChau_a85e ChauveSourisGean_d287 ChienDomestiqueC_8195 ChienViverrinTan_6fe1 ChimereMonstrueu_09b5 CivetteAfricaine_c69f CoatiANezBlancNa_dce3 Coelacanthe_12ea ColobeColobusPol_6118 CoyoteCanisLatra_76cb CrociduraOcciden_3244 CrocodileMarinCr_d96c DauphinAGrosNezB_5aee DauphinDeLaPlata_8197 DingoCanisLupusD_df62 DouroucouliAotus_091c ElephantDAfrique_6308 ElephantDeMerMac_641a EpomophoreDeGamb_9896 FennecVulpesCani_20d4 FossaCryptoproct_9de6 GalagoDemidoviiG_6cf3 GirafeGiradae_f221 GrandRhinopomeRh_0c4e GrizzliUrsusArct_32eb GuepardFelidaeAc_9f0e Gymnure_49a8 HurleurRouxAloua_47da HyeneRayeeHyaene_99d0 KangourouRouxMac_dd51 LangurIndienPith_8390 LemurMongosLemur_b941 LeopardPantheraP_065b LepilemurAQueueR_309f LionPantheraLeo_1799 LoupCanisLupus_dba4 LoutreLutraLutra_7494 LynxFelisRufa_d5e8 MacacaMulatta_875f MacaqueCrabierMa_8f9e MacaqueRhesusMac_bdf8 MakiCattaLemurCa_dec8 MangabeyCercoceb_4458 MangabeyCouronne_6b65 Manis_9475 MarsousetOedipom_e834 MicrocebeDeCoque_e3a9 MicrocebeMignonM_ca6c MicrocebeMignonM_ca6c_head MinioptereDeSchr_5b67 MoustacLasiopygi_23cc NycticebusTardig_08cb NyctimeneAlbiven_5e61 OkapiGiradaeO_a35d Orangoutan_80bb OrnithorynqueOrn_4a62 OtarieDeCaliforn_6095 OtarieDeCaliforn_bae7 OtarieDeKerguele_8bba OuistitiAPinceau_b4aa OursBrunUrsusArc_6caa OursBrunUrsusArc_a916 OursMalaisHelarc_8477 OursNoirUrsusAme_2aed OursNoirUrsusAme_418f OursNoirUrsusAme_d540 OursPolaireThala_2445 PandaGeantAiluro_d4b8 PangolinManis_6a35 PetitRhinolopheR_34a8 PhoqueCommunPhoc_1df3 PhyllorhineDeCom_576f PithecusGermaini_6a2c PithecusGermaini_6a2c_head PumaConcolor_997a RaieBoucleeRajaC_bc9a RatonLaveurProcy_6221 RenardVolantAOre_9f48 RenardVolantMalg_a94e RequinRoussette_e3b7 SaimiriCassiquia_7176 SaimiriCassiquia_eb44 SalamandreGeante_ddc0 SapajouCapucinCe_d971 ServalLeptailuru_2f96 SingeLaineuxLago_0f84 SlothBear_48b3 SolenodonSolenod_fc42 TamanoirMyrmecop_8e13 TamanoirMyrmecop_9b3d TamanoirMyrmecop_e70b TatouDasypusNovi_f181 TaupeCommuneTalp_e3d6 ThylacineThylaci_32df TigreFelisTigris_7ced TortueImbriqueeE_0575 VaranDesSavanesV_dccf VaranDesSavanesV_dccf_head VaranusGriseus_aa49_head VariNoirEtBlancL_4d0e VariNoirEtBlancL_4d0e_body VervetCercopithe_72ae ZebreDeChapmanEq_56cb A The electronic collection of vertebrate brains of the National Natural History Museum of Paris Katja HEUER1,2, Melanie DIDIER3,4, Antoine BURGOS3,4, Stephanie ANASTACIO3,4, Marc HERBIN*5, Mathieu SANTIN*3,4 & Roberto TORO*1,3 1Institut Pasteur 2Max Planck Institute 3Sorbonne Universités, UPMC Univ Paris 06, CNRS, INSERM, APHP GH Pitié-Salpêtrière, Institut du cerveau et de la moelle épinière (ICM) 4Centre de Neuro-Imagerie de Recherche (CENIR) 5UMR7179 MNHN/CNRS, Muséum National d’histoire naturelle de Paris, Dpt AVIV. *Authors contributed equally to this work. katjaqheuer@gmail.com, rto@pasteur.fr King colobus Hanuman langur Loridae Cercopithecini Papionini Lemuriformes Galagonidae Atelidae Cebidae Colobinae Hominoidea 5 cm Human Chimpanzee Bonobo Indochinese lutung Douroucouli Cotton-top tamarin Squirrel monkey Black-pencilled marmoset Red slender loris Gibbon Gorilla Orangutan Hamadryas baboon Grey-cheeked mangabey Sooty mangabey Crab-eating macaque Rhesus monkey Woolly monkey Black spider monkey Green monkey Demidoff's galago Aye-aye Red-tailed sportive lemur Mongoose lemur Black-and-white ruffed lemur Grey mouse lemur Ring-tailed lemur Coquerel's mouse lemur Gorilla Human Bonobo Chimpanzee Orangutan Crab-eating macaque Rhesus macaque Black-and-white ruffed lemur Ring-tailed lemur Coquerel's mouse lemur Tufted capuchin White-faced sapajou Cotton-top tamarin Douroucouli Black spider monkey Ind | poster |
) c (MeV/ TT p δ Recon -400-300-200-100 0 100 200 300 400 ) c (MeV/ TT p δ Truth -400 -300 -200 -100 0 100 200 300 400 0 0.2 0.4 0.6 0.8 1 0 0.2 0.4 0.6 0.8 1 ) c (MeV/ TT p δ Recon -400-300-200-100 0 100 200 300 400 ) c (MeV/ TT p δ True -400 -300 -200 -100 0 100 200 300 400 0 0.2 0.4 0.6 0.8 1 ) c (MeV/ p p Recon 0.4 0.6 0.8 1 1.2 1.4 1.6 1.8 3 10 × ) c (MeV/ p p Truth 0.4 0.6 0.8 1 1.2 1.4 1.6 1.8 3 10 × ) c (MeV/ p p Recon 0.4 0.6 0.8 1 1.2 1.4 1.6 1.8 3 10 × ) c (MeV/ p p Truth 0.4 0.6 0.8 1 1.2 1.4 1.6 1.8 3 10 × ) c (MeV/ p p Truth ) c (MeV/ TT p δ -400-300-200-100 0 100 200 300 400 Counts 0 100 200 300 400 500 600 Fake Data Signal and mesons 0 π Charged mesons Zero mesons Other Signal ) c (MeV/ TT p δ -400 -300 -200 -100 0 100 200 300 400 Data/MC Pass Fail Time Slicing Vertex Position Muon Identification Proton Selection !0 Identification Sample Signal Michel Tagged Low pID Michel Tagged Fail Pass Pass Michel Tagged Signal Low pID ) c (MeV/ γ γ m 0 50100150200250300350400450500 Counts 0 20 40 60 80 100 120 140 160 180 Fake Data Signal and mesons 0 π Charged mesons Zero mesons Other PID ) c (MeV/ γ γ m 0 50100150200250300350400450500 Counts 0 10 20 30 40 50 60 70 80 Fake Data Signal and mesons 0 π Charged mesons Zero mesons Other Michel ) c (MeV/ γ γ m 0 50100150200250300350400450500 Counts 0 20 40 60 80 100 120 140 160 Fake Data Signal and mesons 0 π Charged mesons Zero mesons Other Signal Default True Recon Residual 1 - T µ p -0.5-0.4-0.3-0.2-0.1 0 0.1 0.2 0.3 0.4 0.5 0 100 200 300 400 500 600 700 800 Curvature Fitted Gaussian Mean = -0.02 Width = 0.11 = 153/45 ndf / 2 χ Range Fitted Gaussian Mean = -0.01 Width = 0.07 = 242/45 ndf / 2 χ Measuring nuclear effects in pionic semi-exclusive final states using the MINERvA Detector David Coplowe on behalf of the MINERvA Collaboration david.coplowe@physics.ox.ac.uk Introduction The MINERvA Detector nµ Transverse Plane µ− pµ− p0 pp0 p pp pµ− T pp0 T pp T µ− pµ− T p0 pp0 T p pp T Transverse Plane dpTT = pp TT + pp0 TT A = 1 : pp TT = −pp0 TT A > 1 : pp TT 6= −pp0 TT pp0 TT pp TT Reconstruction Improvements Signal Extraction [1] K. Abe et al. (T2K), Phys. Rev. D97 012001 (2018), [2] P. Adamson (NOvA), Phys. Rev. Lett. 118 (2017) no.15, 151802, [3] NOvA Technical Design Report, FERMILAB-DESIGN-2007-01, [4] R. Acciarri et al. (DUNE Collaboration), arXiv:1512.06148, [5] O. Altinok (MINERvA), Phys. Rev. D96, 072003 (2017), [6] X.-G. Lu, D. Coplowe, R. Shah, G. Barr, D. Wark, and A. Weber, Phys. Rev. D92, no. 5, 051302 (2015) 60 < mgg (MeV) < 200 1.5 < Eµ (GeV) < 20.0 • Situated on-axis in NuMI Beam. • Analysis studies low energy dataset peaked at 3.5 GeV. • Active tracker capable of reconstructing low energy (T = 110 MeV) tracks • Precise directionality (within 3 mm), • Particle identification and momentum provided by dE/dx profiling. • MINOS near detector measures charge and momentum of forward going muons. • ECAL and HCAL aids in full event containment. pp > 450 (MeV/c) c2 pen = (E1−Emeas 1 )2 s2 E1 + (E2−Emeas 2 )2 s2 E2 • Neutral pions identified via dominant decay (ddidavid). • Kinematics determined using photons energy and direction • Momentum limited by photons calorimetric reconstruction, • Angular resolution is good. • Use precise angular determination to improve calorimetric estimates by fitting iiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiii using a penalty term p0 ! gg m2 = 2E1E2(1 −cos q12) Kinematic Constraints qµ < 25◦ • Nuclear effects are currently one of the dominant sources of systematic uncertainty in oscillation measurements [1,2]. • Signal and background selection efficiencies. • Reconstructed neutrino energy spectra. • Measuring final states with exactly one cii, and at least one pii and p. • Will aid in reducing such uncertainties in Multi-GeV oscillation experiments [3,4]. • This work is an extension to the analysis on the ‘delta rich’ sample in [5]. • Nuclear dynamics probed by double transverse momentum (dpiii) — a kinematic imbalance of the hadronic final state [6]. µ− p0 p dpT | poster |
More details in our publication: Gvaramadze, Maryeva, et al., MNRAS, 2019 I am grateful to grant support from Czech Science Foundation GA18-05665S and RFBR grant 19-02-00779. During our search for massive stars on late evolutionary stages in WISE archive we discovered a high-velocity runaway star CPD-64º 2731, associated with a horseshoe-shaped nebula. Its spectral type is O5.5Vn((f)) and projected rotational velocity is ≈300 km/s, which is extremely high for this spectral type. The kinematic age of ≈ 6 Myr, assuming it was born near the Galactic plane, exceeds its age derived from single star models by a factor of two. These properties suggest that CPD-64º 2731 is a rejuvenated and spun-up binary product. The geometry of the nebula and the almost central location of the star within it argue against a pure bow shock interpretation for it. Instead, we suggest that the binary interaction happened recently, thereby creating the nebula, with a cavity blown by the current fast stellar wind. This conclusion is supported by our results of 2D numerical hydrodynamic modeling. The main goal of our project is the search for evolved massive stars through the detection of their mid-IR circumstellar nebulae in Spitzer and WISE archives. The search has led to the discovery of many dozens of previously unknown nebulae. Some of them were found around newly identified massive stars, such as luminous blue variables and blue supergiants (e.g. Gvaramadze et al. 2010). Some others were interpreted as bow shocks produced by known or newly identified OB stars. During the search we discovered a horseshoe-shaped shell of angular radius of ≈30 arcsec in the Circinus constellation. We identified the nebula with the IRAS source 14032−6515, and found within it a massive star, known as CPD−64º 2731. The nebula has attracted out attention because it is associated with a high-velocity runaway main sequence O star, but does not look like a genuine bow shock. Using proper motion measurements for the star from Gaia DR2 we found that CPD−64º 2731 is a high-velocity (≈160 km/s ) runaway star with the vector of its space velocity inclined to our line of sight by ≈33º. The runaway status of CPD−64º 2731 is also supported by the large separation of this star from the Galactic plane of z≈0.5 kpc. CPD−64º 2731 moves almost perpendicular to the Galactic plane and its past trajectory intersects the Galactic plane at l ≈311.5º. In this direction our line of sight first crosses the Carina-Sagittarius arm at ≈1.5 kpc and then tangentially enters into the Crux-Scutum spiral arm at ≈5 kpc. All distance estimates for CPD−64º 2731 imply that this star was formed in the Crux-Scutum arm. The kinematic age of CPD−64º 2731 of ≈6 Myr, assuming that this star was born near the Galactic plane, exceeds its age derived from single star models by a factor of two. We therefore suggest that CPD−64º 2731 is a rejuvenated and spun- up product of binary interaction (a massive blue straggler). We have modeled the interaction between the stellar wind of CPD−64º 2731 and the ISM. To verify our hypothesis that CPD−64º 2731 is the binary interaction product we performed two types of simulation: - bow shock produced by a runaway star whose wind parameters and space velocity were set to be identical to those of CPD−64º 2731 - runaway star was assumed to be initially composed of two ≈20 M ⊙components with identical mass loss rate and wind velocity. After several thousand years, the wind parameters of the binary product were set to be equal to those of CPD−64º 2731, and the new, much faster, wind started to blow a bubble in the preceding slow wind material bounded in the upstream direction by the bow shock. The second scenario reproduces reasonably well the horseshoe shape of the nebula around CPD−64º 2731 and confirms our hypothesis Spectra were obtained with the SALT High Resolution Spectrograph. For modeling we used the stellar atmosphere code CMFGEN (Hillier & Miller 1998). Spectral analysis of da | poster |
Este estudio comparó las características técnicas, prácticas, económicas y ambientales de la producción de biodiésel a partir de materias primas no convencionales, como aceite de linaza y manteca de cerdo. Los reactivos se sometieron a transesterificación en un reactor Batch a 55°C con agitación constante, tomando muestras cada dos horas para estimar la producción de glicerina mediante purga con agua. Los análisis confirmaron la conversión de materiales grasos en ésteres de biodiésel. Los hallazgos indicaron que la producción de biodiésel a partir de materiales alternativos es plausible y sus resultados son acordes al proceso de gran escala en la medida de lo posible, sin embargo, se evidencia una necesidad de adaptación de procesos y materiales para optimizar la obtención de productos. Este estudio incentivo a la búsqueda de alternativas oleo genas a los insumos de fabricación tradicionales para aprovechar estos materiales en un fin útil, reduciendo la contaminación que generan a la vez de ampliar el panorama de los combustibles a largo plazo . Palabras clave: transesterificación; residuos; optimización; biodiesel. Resumen Objetivo General Conclusiones • El estudio demuestra eficacia en el proceso de transesterificación en un porcentaje superior al 90 porciento, siendo positivo para los fines de este proyecto, permitiendo concluir del mismo que es posible utilizar materias no convencionales de tipo oleo gena para producir combustibles tipo diésel natural. Por otra parte, es importante resaltar que el estudio en pequeña escala se ve limitado por las capacidades y compatibilidades del laboratorio que, en su forma, ayudan a realizar de manera más controlada y exacta el experimento. • También es notable destacar que el uso de materias no convencionales en experimentos de escala micro resulta en un gasto masivamente superior que, si fuera a escala macro, principalmente por los procesos "no industrializados" que requieren ser llevados a mano, incrementando significativamente el tiempo en el que los resultados son visibles además del ámbito económico Referencias Llanes Cedeño, E. A., Rocha-Hoyos, J., Salazar Alvear, P., & Medrano Barboza, J. (2017). Producción e Impacto del Biodiesel: Una Revisión. https://dialnet.unirioja.es/descarga/articulo/6069992.pdf. Producción e Impacto del Biodiesel: Una Revisión. (s.f.). https://dialnet.unirioja.es/descarga/articulo/6069992.pdf. Cruz, A. (2018). Producción de Biodiesel. https://www.academia.edu/36006115/Art%C3%ADculo_Producci%C3%B3n_de_Biodiesel. Resultados Comparar las características técnicas, practica, económicas y ambientales de la producción de biodiésel a partir de materias primas no convencionales, como el aceite de linaza y el aceite animal. Escuela de Ciencias Exactas e Ingeniería Ingeniería Ambiental Víctor Augusto Lizcano Sandoval Juan Barrios, Juan Hueso, María Pinzón, Axel Ortiz Gas Oink Lina: Innovación y Eficiencia en el Suministro de Combustible Metodología Preparación de los reactivos: Derretir la manteca de cerdo al baño maría (no superar 55 grados para evitar que las impurezas se friten). Filtrar la grasa derretida usando un colador metálico y un embudo, y transferir en otro vaso de precipitado hasta que se enfríe levemente, permitiendo que pueda ser colocado en el reactor Preparación de los reactores: Introducir la mezcla en el reactor. Ajustar la temperatura del reactor a 55°C utilizando un termómetro. Mantener una agitación constante usando el agitador magnético para asegurar la homogeneidad de la mezcla. Reacción de transesterificación: Introducir la mezcla en el reactor. Ajustar la temperatura del reactor a 55°C. Mantener una agitación constante usando el agitador magnético para asegurar la homogeneidad de la mezcla. Toma de muestras: A intervalos regulares (cada 2 horas para cantidades pequeñas), tomar muestras de la mezcla en un vaso de precipitado para analizar la cantidad de biodiésel producido. Registrar los resultados con la hora y el porcentaje de producción d | poster |
The Tools of Open Notebook Science Platforms Supplemental | poster |
Making Cultural Heritage Data easier to access, more sustainable, reproducible and citable. Supporting collaboration between all those working with and on digital data originating from Cultural Heritage Institutions Offering a comprehensive framework including all aspects relevant to Cultural Heritage data re-use Which digital data? Which benefits? For which actors? Metadata Annotation can be shared, enriched and disseminated by the Charter partners. All partners in the Charter will benefit equally from the greater visibility and communication made possible by joining forces. Scholars Research Institutions Cultural Heritage Institutions Data Hosting Bodies Cultural Heritage Labs •• Sustainability •• Citation •• Access •• Reproducibility 1. Register according to your personal or institutional profile. 2. Get in touch with the cooperation partners and collections relevant to your activities. 3. Gather information on relevant topics such as licensing. 4. Gain visibility and recognition in the international research ecosystem. As a scholar joining the Charter, you can position yourself in the research eco system by: • • declaring your wil- lingness to follow the requirements of the Cultural He- ritage Institutions and the collections you would like to work with • • declaring the licen ses you use for your work (informa- tion on licensing is provided) • • defining how you want to be cited by the signed-up members of the Charter you work with •• abiding to the Charter Code of Ethics (correct citation of your own work, of your partners, of your image). You can determine the conditions of your public online presence by choo- sing how much infor- mation you wish to share. With a clear and open citability of all the partners, you can benefit from ever-in- creasing resources: • • precise information on the collections that might interest you • • direct contact with the person respon- sible for the collec- tion or topics you are interested in •• new opportunities of cooperations •• better metadata and data quality •• better overall visibi- lity of the actors as well as resources. As a Cultural Herita- ge Institution joining the Charter, you can offer your collections a new visibility by: • • using a platform that allows to co- ordinate with all concerned actors (Cultural Heritage Labs, Data Hosting Bodies, Research) • • defining precisely, for each collection and each type of data associated to them, the condi- tions for their re- use •• addressing ques- tions of hosting and dissemination of data resulting from experiments on Cultural Heri- tage assets within a comprehensive framework. •• Types of primary sources •• Data formats •• Forms of enrichment •• Individuals and institutions •• General and specific declarations •• Possible move to citizen science Text Scans with the support of the H2020 research program of the European Union Cultural Heritage Charter Data Re-Use Anne Baillot (Centre Marc Bloch) Laurent Romary (Inria) Contact charter@dariah.eu licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) | poster |
4. Discussion Throughout u3Green, the main advantages and challenges of working in teams with young citizen scientists become visible. Participation of young people introduces new ideas and asks experts to change their perspective. However, it requires comprehensive planning and particular pedagogical skills to keep young people engaged (e.g., keep them interested and motivated) Literatur Fors, H., Hagemann, F.A., Sang, Å. O. & Randrup, T. B. (2021). Striving for inclusion. A systematic review of long-term participation in strategic management of urban green spaces. Frontiers in Sustainable Cities 3:1-27. https://doi.org/10.3389/frsc.2021.572423 Goderbauer, E. (2023). Jugendbeteiligung in der Stadtentwicklung. Ein Blick aus der Stadtforschung. Geographische Rundschau 2023(4):24-29. Vogler, R., Hennig, S., & Albrecht, F. (2023). Urban Green for Child-and Youth-Friendly Cities. GI_Forum 2023(1):118-139. https://doi.org/10.1553/giscience2023_01_s118 Contact u3Green-Team (Tim Schötz, Sabine Hennig, Robert Vogler) Department of Geoinformatics – Z_GIS University of Salzburg tim.schoetz@plus.ac.at 1. Objectives u3Green pursues three objectives: 1. gaining general knowledge about the importance and use of urban green by children and the youth 2. developing a web-based, child- and youth-centred application for collecting and reporting information on urban green spaces (u3Green-app) 3. communication of the findings (i.e., analyze results of the data contributed using the u3Green-app) via suitable geo-visualization products 2. Methods, tools, workflow Based on a basic knowledge, a survey application is created which is then used to survey the locations and characteristics of urban green spaces (Fig. 1). The collected data is then evaluated and communicated. Geomedia products from Esri (e.g., ArcGIS Online, Survey123, Insights, StoryMaps) are used to record, evaluate and communicate the results. Young people, i.e., school students, are involved in all phases of the project through various participation formats. These include school workshops, short and long-term internships. 5. Conclusion, outlook The collected data is analyzed using geomedia (e.g., StoryMaps, ArcGIS Insights) and then communicated to the city in a publicly effective way. u3Green is therefore intended to improve the consideration and participation of young people in urban green planning processes and raise social awareness. 3. Results The data collected via the u3Green-app represent key results focusing on children and young people. An initial analysis of the data shows the following (Fig. 2): 1) Going for a walk is a core activity for the use of urban green spaces; 2) Free Wi-Fi, cleanliness and security, e.g., a ban on alcohol and other drugs, were highlighted as important characteristics of urban green spaces; 3) In addition, the u3Green project provides important insights into the participation of young people in urban planning processes for urban green spaces. u3Green Participation and citizen science with young people u3Green is funded by the Federal Ministry of Education, Science and Research in the Sparkling Science 2.0 program. Going for a walk Wi-Fi Cleanliness Security Fig. 2: Selected results of the u3Green survey The provision of urban green spaces is becoming increasingly important due to the declining living conditions in cities. However, the demands of young people and adults often vary considerably and are not well understood. Furthermore, there are deficits in the participation of children and young people in urban planning, although their involvement in the relevant processes is becoming increasingly important. One of the reasons for this is the specific involvement of young people in citizen science initiatives. The u3Green project addresses these challenges by following the citizen science co- creation approach. Fig. 1: u3Green workflow 1. Understand 2. Develop 4. Analyze 5. Communicate workshops short-term internships long-term internships Basic know | poster |
A life expectancy estimator eventually helps personalising care to prevent under- and overuse of preventive care in the growing older population. Abstract citation ID: ckac130.052 Changing epidemiology and trends in incidence of kidney cancer in England, 1985-2019 Anjum Memon Y Salari1, P Bannister1, A Memon1 1Brighton and Sussex Medical School, Department of Primary Care and Public Health, Brighton, UK Contact: a.memon@bsms.ac.uk Background: Kidney cancer is the 7th most common cancer in the UK, accounting for 4% of all new cancer cases. The risk factors for kidney cancer include obesity, smoking, hypertension, and exposure to certain environmental and occupational carcino- gens. We conducted a retrospective population-based cohort study to examine whether there have been changes in the incidence of kidney cancer in England during the past four decades. Methods: Individual level data for patients diagnosed with kidney cancer in England during 1985-2019 were obtained from the Office for National Statistics/Public Health England. Average annual incidence rates were calculated by two age categories (0-49, 50+ years) and all ages combined during the seven five-year time periods (1985-89 to 2015-19). The percentage change in incidence was calculated as change in the average annual incidence rate from the first (1985-89) to the last time period (2015-19). Results: During the 35-year study period, a total of 197,819 new cases of kidney cancer were registered in England (62.4% males, 37.6% females). In young people aged 0-49 years, the average annual incidence rates increased by 164% in males and 144% in females (from 1.4/100,000 in 1985-89 to 3.7/100,000 in 2015-19 in males and from 0.9/100,000 in 1985-89 to 2.2/ 100,000 in 2015-19 in females). In older people aged 50+ years, the rates increased by 129% in males and 147% in females (from 24.5/100,000 in 1985-89 to 56.0/100,000 in 2015-19 in males and from 11.9/100,000 in 1985-89 to 29.4/100,000 in 2015-19 in females). Conclusions: There has been a steady and significant increase in the incidence of kidney cancer in England over the past four decades. The largest increase (164%) was observed in young males aged 0-49 years, which was unexpected. Considering the risk factors for kidney cancer, further research is needed to understand the role of environmental/occupational exposures in causing kidney cancer. Key messages: About 24% of kidney cancers in the UK are attributed to obesity and 13% to smoking. This research highlights the benefits of reducing the prevalence of obesity and smoking in the general population. The unexpected significant increase in the incidence of kidney cancer in young people aged 0-49 years needs further investigation. Abstract citation ID: ckac130.053 Changing epidemiology and trends in incidence of thyroid cancer in England, 1985-2019 Anjum Memon R Stonell1, P Bannister1, A Memon1 1Brighton and Sussex Medical School, Department of Primary Care and Public Health, Brighton, UK Contact: a.memon@bsms.ac.uk Background: Thyroid cancer is 2-3 times more common in females and is currently the fastest growing cancer worldwide. Exposure to ionizing radiation is the only established risk factor for thyroid cancer. Other factors include obesity, history of benign thyroid conditions, and family history. We conducted a retrospective population-based cohort study to examine whether there have been changes in the incidence of thyroid cancer in England during the past four decades. Methods: Individual level data for patients diagnosed with thyroid cancer in England during 1985-2019 were obtained from the Office for National Statistics/Public Health England. Average annual incidence rates were calculated by two age categories (0-49, 50+ years) and all ages combined during the seven five-year time periods (1985-89 to 2015-19). The percentage change in incidence was calculated as change in the average annual incidence rate from the first (1985-89) to the last time period | poster |
Analítica de Datos en Medidores Inteligentes para la Detección de Robo de Energía Juan C. Olivares-Rojas, Enrique Reyes-Archundia, José A. Gutiérrez-Gnecchi, Johan W. González- Murueta, Adriana Téllez Anguiano Tecnológico Nacional de México / Instituto Tecnológico de Morelia Resumen Resultados Introducción Métodos y Materiales Conclusión Referencias Con los parámetors p, q y d obtenido de los modelos más generales se procede a la elección del modelo definitivo, para ello se utilizó la función auto_arima() de la biblioteca pyramid-arima. Para nuestro ejemplo el modelo seleccionado fue: ARIMA(0, 1, 4). Para la definición del mejor modelo se utlizan métricas como RMSE, MAPE, MAE, AIC y BIC normalizado. Una vez entrenado el modelo se procede finalmente a la predicción de valores futuros. Como puede observarse, el margen de acierto de valores está encima del 95%, por lo que se considera como un buen patrón de perfil de consumo de dicho medidor (Figura 5) El robo de energía es la principal pérdida no técnica de las empresas suministradoras del servicio eléctrico. Con la introducción de medidores inteligentes se registran las lecturas de medición del consumo y producción de energía eléctrica de forma más periódica, lo cual conlleva al posterior uso de esta información. En este trabajo se presenta la analítica de datos de las lecturas de consumo/producción de energía eléctrica de medidores inteligentes que permite determinar un patrón de consumo/producción de energía eléctrica para identificar si los consumos/producción de energía eléctrica pueden ser considerados como robo de energía. Las Redes Generales de Distribución, en CFE Distribución, perdieron en 2017 un 7.96 % de la energía recibida en pérdidas no técnicas con un volumen de 18,268 GWh, esto representó pérdidas económicas significativas para la compañía CFE Distribución [2018]. Tradicionalmente, los medidores de electricidad se instalan en los establecimientos del consumidor y la información de consumo se recopila mediante toma de lecturas a los medidores a través de lecturistas en sus visitas mensuales o bimestrales, dichos medidores son analógicos y presentan ciertas desventajas tanto para el consumidor como para la compañía eléctrica. Al contar con estos medidores, no se puede evitar el error humano en la lectura manual del medidor, existen altas posibilidades de robo de energía eléctrica, ya sea mediante el uso de diablitos, alteración de componentes mecánicos, eléctricos y electrónicos del medidor para cambios de lecturas de los medidores, entre otros. Este trabajo muestra que es posible detectar robos de energía utilizando datos y procesamiento del medidor inteligente. Los resultados indican que la detección de anomalías de consumos/producción de energía eléctrica es adecuada pero que como todo modelo de pronóstico la intervención humana juega un papel relevante en la toma de decisiones. Es importante recalcar que el modelo propuesto ajusta sus parámetros y cantidad de valores de entrenamiento/ajuste a fin de que se ejecuten de forma adecuada en dispositivos embebidos con capacidades de cómputo limitadas. CFE Distribución (2018). Programa de ampliación y modernización de las Redes Generales de Distribución 2018-2032. https://www.cfe.mx/epsdistribucion/cumpliminetoregulatorio/Docu ments/PAM%20de%20las%20RGD%202018-2032.pdf. Fecha de consulta 15 de julio de 2019. Velarde Martínez, A. (2003). Minería de Datos. Una Introducción. Conciencia Tecnológica. (23) Dua, D. and Graff, C. (2019). UCI Machine Learning Repository. Irvine, CA: University of California, School of Information and Computer Science. https://archive.ics.uci.edu/ml/datasets/Individual+household+electric +power+consumption?. Fecha de consulta 17 de junio de 2019. Se utilizó la metodología tradicional de KDDD listado en la Figura 1. Se tomó un repositorio de la UCI de Dua y Graff [2019] además de las bases de datos de los medidores inteligentes implementados. En primera instancia se hizo una selección de los da | poster |
#063E3E Introduction 1. Active Region Detection & Classification 2. Flare Forecasting Results Active Region Detection Automated detection of active regions from full-disk images (right) Active Region Classification Automated classification of active region cutouts (Hale / Zurich) Point-in-Time Flare Forecasts Given observations from a single time (e.g. Magnetogram & EUV) generate a 24 hour forecast flare probability Time Series Flare Forecasts Given a times series of observations forecast time series of flare probabilities (e.g. every 3 hours for next 24 hours) Code releases will be public on GitHub: github.com/arcaff ●Datasets, software (Python packages with documentation), and research findings ●Dataset generation tools & PyTorch “DataLoader” objects will allow for easy benchmarking and direct comparison of models Model Deployment and Monitoring ●Continuous monitoring to track performance metrics and detect data/concept drift ●Results will seamlessly integrate with SolarMonitor.org and PITHIA-NRF.eu The Sun is an enigmatic star that produces the most powerful explosive events in our solar system solar flares and coronal mass ejections. Studying these phenomena can provide a unique opportunity to develop a deeper understanding of fundamental processes on the Sun, and critically, to better forecast space weather. The Active Region Classification and Flare Forecasting (ARCAFF) project will develop a beyond state-of-the-art flare forecasting system utilising end-to-end deep learning models to significantly improve upon traditional flare forecasting capabilities. In particular ARCAFF aim in improve on the accuracy of current methods and introduce the concept of time series forecasts. NOAA AR #: Hale: Zurich: Latitude Longitude 13176 Beta Dki 19° -50° Example training data for NOAA AR 13176 (right) ARCAFF: Active Region Classification & Flare Forecasting Paul Wright, Shane Maloney, Sophie Murray, Peter Gallagher, (Dublin Institute for Advanced Studies) Anna Massone, Michele Piana, Valentina Candiani, Sabrina Guastavino, (University of Genova), Tamas Kiss, Gabriele Pierantoni, Gabor Terstyanszky, (University of Westminster) Robert Lovas, Attila Farkas (Sztaki; Institute for Computer Science and Control) github.com/arcaff www.arcaff.eu @ARCAFF_EU Time Flare Prob (>M) Mockup of time series forecast for at least M class flare Current Time 13171 Beta Cao 23° 39° 13173 Alpha Hsx 25° -10° 13175 Alpha Axx -20° -29° 13169 Beta-Gamma Fkc 22° 60° | poster |
What would you do if you lost your research data tomorrow? Take the research data health check… and find help to secure, share and exploit your valuable research. Chances are you could use some helpful pointers in all of these! To find information, support, advice and training, as well as links to external resources, go to www.le.ac.uk/researchdata or email: researchdata@le.ac.uk fully understood your research funders’ data management requirements? Government and funders require that publicly funded research is made available for reuse – are you up to date with their latest policies? Your future funding might depend on it! written a data management plan? Your funder may already require this but build it in from the proposal stage to avoid headaches in the future. gained ethics approval/consent? Writing a data management plan will aid planning and help you to navigate ethics and governance requirements. protected your intellectual property? Leaving intellectual property considerations for a rainy day could lose you appropriate credit, damaging career prospects and perhaps your financial future health! clearly described, in terms of content (using standard metadata)? Ask yourself honestly: is there a danger of data being lost? Will you be able to remember how you generated your data, and will you or anyone else be able to find it in the future when you wish to reuse and share? clearly labelled with versions and dates? How will you remember which was the definitive version and which dataset was used in producing a given research outcome? logically structured and named? Once you’ve remembered how you generated data, can you still find the relevant files? future-proofed against broken links, using persistent identifiers? The persistent identification of digital resources can play a vital role in enabling their accessibility and re-usability over time using recommended data standards. how to restrict access to your research data to the right people? Have you consulted with university or data centre experts so that only the right people have access to your research? which data to keep and which data to discard? Managing research data effectively means being selective: which data to discard and when as well as what to keep and for how long? how securely your data is stored? What happens if your storage media fail? How resilient is it? Could it get left on the train and could somebody else misuse it? how your data is backed-up? Have you made use of university and/or external resources to back up data so that you have multiple copies in case of loss or theft? Organise Create Have you... Are your research files and data... Do you know... Keep find existing information resources related to your research? Where can you find research data that you can repurpose or combine with your own to produce new research? share data with your collaborators securely and effectively? Whether building a collaborative proposal, generating results for others to comment on or sharing the final outputs of your research – how will you link with your colleagues ahead of wider sharing? deposit your research data and outputs in an open repository? Is there an appropriate disciplinary or institutional repository and what do you need to do to deposit your research output? Plan ahead to avoid refactoring... publish your research, and get it cited as well? Institutions and data centres must make research data reusable to others while providing credit to the researchers who did the work. Your future career could depend on it! Find & Share Do you know how to... | poster |
Revealing Patterns of Symptomatology in Parkinson's Disease: A Latent Space Analysis with 3D Convolutional Autoencoders E. Delgado de las Heras, F.J. Martinez-Murcia*, I.A. Illán, C. Jiménez-Mesa, D. Castillo-Barnes, J. Ramírez, J.M. Górriz Dpt. Signal Theory, Networking and Communications. University of Granada (Spain) 1. INTRODUCTION 2. METHODOLOGY 2.2 3D CONVOLUTIONAL VAE 3. RESULTS 96 128 3 3 3 3 3 3 3 3 512 σ μ d 32 64 128 256 48 64 24 32 12 16 6 8 96 128 48 64 24 32 12 16 6 8 3 3 3 3 3 3 3 3 SAMPLING 256 128 64 32 ENCODER DECODER Nd(μd,σd) 2.1 DATASET 2.3. EVALUATION 5. CONCLUSIONS This work proposes a novel approach to detect and quantify subtle changes in DaT concentration and distribution in the brain using 3D convolutional variational AEs (CVAEs). The composite variables of the latent space are then modelled using Decission Trees and XGBoost regression, and the spaces are interpreted through visualization and SHAP. Data used for this work was obtained from the Parkinson's Progression Markers Initiative. Specific cohort from the PPMI database that follows individuals diagnosed with PD and Healthy Control subjects (HC) during 5 years, recording symptomatology via the MDS-UPDRS scale. All the Ioflupane I-123 SPECT scans have been intensity normalized to non-specific areas and a sigmoid function was applied to compress the high-intensity values. - Use the μ parameters of the latent distribution Nd(μd,σd) as features. - K-Means features (KMF) are generated to capture important data characteristics. - Regression using Decision Trees (DT) and XGBoost. - Performance metrics such as Mean Absolute Error (MAE), Root Mean Squared Error (RMSE), and coefficient of determination R2 are computed using 10-fold cross- validation. - SHapley Additive exPlanations (SHAP) is applied to the outputs of each system. Parkinson's disease (PD) affects more than 6.2 million people worldwide. It is characterized by a loss of dopamine-producing neurons in the brain, causing tremors, rigidity, and cognitive decline among other symptoms. Ioflupane I-123 binds to the presynaptic dopamine transporters (DaTs), allowing to visualize and quantify DaT concentration at the striata, For top performing 20-D XGB model of UPDRS (total), SHAP reveals: - top-3 features that contribute to the output of the algorithm are latent variables 2, 10 and 0. - Approx. linear dependency between importance to the algorithm output and values of the latent variables. - Composition of variables 2 and 10 accounts for relevant characteristics of Ioflupane SPECT imaging: the general intensity of the striata, the separation between them and the uptake ratio between its anterior and posterior parts. - Anterior-posterior uptake ratio more related to progression in the first symptoms. Average intensity for the automatic diagnosis of PD. which is key to characterize PD in SPECT imaging. Early detection and monitoring of PD progression could be tackled by modelling a self- supervised, low-dimensional representation of a FPCIT dataset, which enables us to longitudinally compare images and identify patterns of change that are indicative of neurodegeneration. - The latent features of trained CVAEs are related to different aspects of the MDS-UPDRS scale with R2>0.20. - Best performance for UPDRS (total) with latent variables 2 and 10. - Anterior/Posterior ratio are more related to progression of the first symptoms. Average striatal intensity for the diagnosis of PD. This work paves the way for exploratory analysis of links between neuroimaging patterns and neurological disorders in an hypothesis-free environment. MANIFOLD EXAMINATION *fjesusmartinez@ugr.es. Signal Processing and Biomedical Applications (SiPBA). Signal Processing and Biomedical Applications http://sipba.ugr.es SiPBA - R2>0 for almost all target UPDRS categories and d- dimensional latent spaces. - Low latent dimensionality (3, 8) is generally for individual perceived symptomatology (UPDRS 1, 2 and 4). - UPDRS - total is better accou | poster |
Genetic control of circuit development and function in the zebrafish optic tectum Elena Putti*, Chung-Yuen Chan, Giulia Faini, Dimitrii Tanese, Valentina Emiliani, Filippo Del Bene Neuronal Circuit Development Lab , U968 Inserm – UMR 7210 CNRS Institute de la Vision, PARIS * presenting author, contact: elena.putti@inserm.fr (1) Petros et al., Annu Rev Neurosci, 2008 (2) Gebhardt et al., Nat Comm, 2019 (3) Del Bene et al., Science, 2010 (4) Abdelfattah et al., Science, 2019 (5) Di Donato et al., Genome Research, 2016 Binocular cues can be processed through the direct superposition of ipsi and contralateral retinal inputs1. Although lacking ipsilateral retinal projections, the zebrafish larva shows responses to prey-like stimuli consistent with binocular vision. Previous work of the lab has shown the existence of fundamental neurons essential for this behavior, the intertectal commissural neurons (ITNs)2. ITNs connect tectal hemispheres as a ladder-like array of axonal tracts. These commissural interneurons are key to 3D perception in binocular vision, as they form an intertectal circuit that governs the prey-capture behavior, however their precise function and formation remains elusive. The main goal of this project is to investigate the genetic identity, connectivity and mechanism of action of ITNs. We will take advantage of single cell RNA sequencing in order to dissect the genetic identity of ITNs and further define their role in binocular vision during larval development. Classical molecular biology and behavioral experiments will be used to alter the activity and neuromodulation of these neurons. Moreover, calcium and voltage imaging will be employed to dissect the neuronal circuitry controlled by the ITNs3,4. The hunting sequence in zebrafish larvae is a complex but well characterized behavior. It consists of an initial foraging step where the larva swims in the water, followed by the detection of the prey and its tracking. The larva then fixates on its target before initiating the capture maneuver. When the prey is detected in the strike zone the animal converges its eye in order to increase the binocular field of view. In the zebrafish larva the processing of binocular cues is achieved through the activation of the ITN mediated circuitry by the contralateral RGCs2. 1. from RGCs to ITNs 2. from ITNs to PVNs Dissecting ITNs genetic identity Altering ITNs activity/neuromodulation 2-photon dissection of ITNs neuronal circuitry: The transcriptome profile of ITNs will be established thorugh FACS sorting and single cell RNA sequencing methodologies. The combination of the GAL4 - UAS system with the with the CRISPR/Cas9 technology allows targeted mutagenesis in a tissue specific manner, as previously shown in the lab.5 This tool will be employed to alter ITNs activity and neuromodulation and further assess their involvment in the hunting behavior of larval zebrafish. To characterize the neuronal circuitry controlled by the ITNs we are validating new transgenic lines expressing: 1. an opsin at the presynaptic level 2. GECIs (genetically encoded calcium indicators) or GEVIs (genetically encoded voltage indicators) in the post synaptic cells. With this approach we aim at defining the connectivity between RGCs and ITNs (1) and between ITNs and PVNs (2). a. Tg(vglut:gal4;UAS:opsin;elavl3:gCaMP6s) b. Tg(elavl3:voltageindicator) U6 5xUAS sgRNA1 sgRNA2 Cas9 Tol2 site Tol2 site U6 2a Cre ITN mediated prey – hunting behavior From Di Donato et al., 20165 From Gebhardt et al., 20192 Tg(vglut:gal4;UAS:opsin;elavl3:gCaMP6s) Tg(elavl3:voltageindicator) 3 dpf 4 dpf a) b) 3 dpf This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement #813457. | poster |
RE Future Energy Mixture Mohamed Sherwali. Renewable Energy Authority of Libay ( REAOL) 1.Context Contact: Mohamed Sherwali [ msherwali@outlook.com] 5. Policy insights, conclusions and future work 3.Methods & Scenarios Reference Energy System 2.Aim • Libya relying on natural gas and oil to meet the electricity deman. • As there is no renewable is installed yet to the grid, it could be the situation in the future, therefore, the fossil fuel future scenario has been done • In order to reduce CO2 emission and include RE technologies in the power generation mixture as the government set a strategic plan to invest 6 GW in solar and wind technologies by 2035 (1), thus this scenarion has done to investigate CO2 reduction and the needed Dollar investmet • In this study, it has been compared the CO2 emissions and the needed investment between relying just on natural gas and oil to produce electricity in the future, with involving wind and solar technologies for the electricity generation mixture. • Hydro and geothermal sources were not considered as Libya has no potential for these technologies. • Second scenario is to invest about 6 GW in solar and wind by the end of 2035 and what would be the technology to invest more afte 2035 4.Results Country Flag Figure2. Libya Referenve Energy System. 6.References [ 1] The word bank, task D: Strategic Plan for Renewable Energy Development, Least Cost expansion Plan, 12th December, 2017 Mark Howells, Jairo Quiros-Tortos, Robbie Morrison et al. Energy system analytics and good governance -U4RIA goals of Energy Modelling for Policy Support, 10 March 2021, PREPRINT (Version 1) available at Research Square https://doi.org/10.21203/rs.3.rs-311311/v1 Carla Cannone, Lucy Allington, Nicki de Wet et al. clicSAND for OSeMOSYS: a user- friendly interface using open-source optimisation software for energy system modelling analysis, 09 February 2022, PREPRINT (Version 1) available at Research Square https://doi.org/10.21203/rs.3.rs-1338761/v1 Lucy Allington, Carla Cannone et al. Selected ‘Starter kit’ energy system modelling data for selected countries in Africa, East Asia, and South America (#CCG, 2021), Data in Brief, Volume 42, 2022,108021, ISSN 2352-3409, https://doi.org/10.1016/j.dib.2022.108021. … • Is the investment in solar and wind technologies the optimal solution in order to reduce the relying on natural gas and oil to produce electricity? • Its clearly that Fossil fuel scenario is lower cost in term of future investment, on the other hand, the CO2 emissions is very high, as a result this scenario has negatively impact for the environment, also the consequences of future emission penalties • The Government plan to invest 6 GW in solar and wind technology by the end of 2035 is valid in order to reduce CO2 in a lower cost methodology. • Model results suggest to invest in wind technology after year 2035. • Future work: • More assesment for RE scenario. • Flixibilty anaylsis: the impact of the varaible energy to the national grid. • Net Zero scenario by 2070. Map of the country JOINT SUMMER SCHOOL ON MODELLING TOOLS FOR SUSTAINABLE DEVELOPMENT | 2022 Figure1. A Cost-benefit analysis of Policy, Programs and Projects (C3PO) that is Retrievable, Reusable, Repeatable, Reconstructible, Interoperable and Auditable (u4RIA) | poster |
A map of genetic variation from 781 soybean genomes Soon-Chun Jeong1,*, Myung-Shin Kim1, Roberto Lozano2, Ji Hong Kim1, Dong Nyuk Bae1, Man Soo Choi3, Soo-Kwon Park3, Michael A. Gore2, and Jung-Kyung Moon4 1Bio-evaluation center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Korea 2Plant Breeding and Genetics Section, School of Integrative Plant Science, Cornell University, USA 3National Institute of Crop Science, Rural Development Administration, Wanju, Korea 4Agricultural Genome Center, National Academy of Agricultural Sciences, Jeonju, Korea *Corresponding author: scjeong@kribb.re.kr Introduction Soybean (Glycine max [L.] Merr.) is an important crop species. The cultivation of soybean has been historically confined to East Asia. Its cultivation area has been recently expanded to North America, South America, and India, positioning it as one top crop in terms of growing area worldwide. After the release of the draft soybean genome sequence, efforts to map soybean genetic variation by single nucleotide polymorphism (SNP) array genotyping have resulted in the global picture of common and rare SNPs across the genome. However, those data have been poorly used as an integrated manner to serve as haplotype information by imputation approaches that enrich the above SNP genotype data with whole genome SNP data. The resultant genomic data set could also be leveraged as a reference panel to enrich sparse data sets generated from platforms such as low-density SNP array, genotyping- by-sequencing (GBS) or skim sequencing. In addition, genetic variation of wild soybean, which contains a large amount of untapped and unexplored soybean diversity, remains poorly characterized relative to that of domesticated soybean. Here we report genomes of 781 soybean accessions consisting of 418 G. max, 345 G. soja, and 18 hybrid (G. max x G. soja) accessions obtained through high-coverage (> 13x) whole-genome sequence data. We conducted a comprehensive characterization of genetic variation including profiling and functional significance of rare and common genetic variants and detection of domestication-selective sweeps. We are then attempting to show the usefulness of our data in soybean genetics by imputing the SNP data set from 50K US SNP array genotyping using variants identified here for association analyses of protein and oil traits. Materials and Methods Resequencing data from a total of 855 samples were obtained for initial variant calling in this study. We then essentially followed procedures described in the Genome Analysis Toolkit (GATK) Best Practices for data pre-processing and variant calling. Principal component, fastStructure Bayesian clustering, and Neighbor-joining tree construction was used to infer population structure. Historical recombination rate, linkage disequilibrium decay, genomic evolutionary rate profiling, Sorting Intolerant From Tolerant 4G, cross-population composite likelihood ratio test, and genome-wide association studies were performed to infer nucleotide variation pattern, identify selective sweeps, and find association between genotypes and phenotypes. Results and Discussion High heterozygous samples were excluded from further analyses. Distributions of inbreeding coefficient per individuals in subgroups divided by species and heterozygosity indicated that most samples excluded by the high heterozygosity showed an inbreeding coefficient of less than 0.8. Final 781 accessions consisted of 418 G. max, 345 G. soja, and 18 hybrid (G. max x G. soja) accessions. Results and Discussion As observed in the previous study, the 781 accessions were clearly divided into one G. max group and two G. soja groups with a distinct subgroup of G. soja accessions collected from the middle region of the Yellow River basin. Abstract Soybean is an economically and environmentally important major crop worldwide. It is a predominant plant protein and oil source of both food and feed and has capacity to fix atmospheric n | poster |
tx 1. Introduction Development and Initial Results from the Inclusion of Evaporation into a 2D dermal absorption model Benjamin Deacon1,2, Samadhi Silva1, Guoping Lian1,2, Marina Evans3, Tao Chen1 b.deacon@surrey.ac.uk 1. University of Surrey, GU2 7XH 2. Unilever, Bedford, 3. US EPA, NC 2. Evaporation 4. Conclusion 3. Model Results References In experimental scenarios, diffusion into the skin is affected by skin and chemical properties; however, in real life scenarios the vehicles' ability to deliver the active into the skin is impacted by the environment. As such evaporation of the vehicle will occur. Where evaporation will depend on the molecular weight, boiling point, vapour pressure and solubility of the solute and the temperature. The main aim is to develop an evaporation code which will be integrated into the Surrey model to improve the finite dose application. Main conclusions: • The model simulated evaporation time course • The model can be applied to a wide range of chemicals • Needs further validation with experimental data Future work includes: • Further application of the model • Experimental work for validation of the model We simulate evaporation of up to three ingredients under ideal and non-ideal conditions. Non-ideal evaporation allows ingredients in the vehicle to interact and this impacts evaporation. The main equations for evaporation of the active ingredients are given below, including calculation of diffusion coefficient and Fick’s law of diffusion: The results shown below have considered a two ingredients vehicle of Water: Diethanolamine at a starting dose of 10.6 ug/L. This dosage is inline with Hewitt et al, 2020. All simulations here have been performed at 32 oc for 24 hours. 𝐷!"#$%& = 𝐵𝑜𝑙𝑡𝑧𝑚𝑎𝑛𝑛𝐶𝑜𝑛𝑠𝑡𝑎𝑛𝑡∗𝑇 6𝜋𝜂𝑟 𝐶𝑜𝑛𝑐!"#$%& = 𝑃'"#$%& × 𝑀𝑜𝑙𝑒𝐹𝑟𝑎𝑐𝑡𝑖𝑜𝑛𝐴𝑐𝑡𝑖𝑣𝑒 𝑅𝑔× 𝑇 𝐽!"#$%& = 𝐷'"#$%&× 𝐶𝑜𝑛𝑐−0 ℎ 𝑑𝑦 𝑑𝑡'"#$%& = −𝐽'"#$%& × 𝐴 The choice of chemicals and the experimental conditions (skin thickness and dosage) have been informed from Hewitt et al., 2020. This poster has shown evaporation for Water: Diethanolamine (MW 105, Solubility 100 g/100ml, Vapour Pressure 0.03 Pa). This model makes the following assumptions: • Condensation has not been considered. • Wind has not been considered • There are no traces of the active present in the atmosphere at t = 0. • The simulation occurs at standard pressure. 0 0.0005 0.001 0.0015 0.002 0.0025 0.003 0.0035 0.004 0.0045 0.005 0.99965 0.9997 0.99975 0.9998 0.99985 0.9999 0.99995 1 Activity Mole Fraction of Water Activity of Diethanolamine Ellison CA, Tankersley KO, Obringer CM, Carr GJ, Manwaring J, Rothe H, et al. (2020) Partition coefficient and diffusion coefficient determinations of 50 compounds in human intact skin, isolated skin layers and isolated stratum corneum lipids. Toxicology in Vitro. Chen, L., G. Lian and L. Han (2008). "Use of “Bricks and Mortar” Model To Predict Transdermal Permeation: Model Development and Initial Validation." Industrial & Engineering Chemistry Research. Hewitt, N. J., S. Grégoire, R. Cubberley, H. Duplan, J. Eilstein, C. Ellison, , et al. (2020). "Measurement of the penetration of 56 cosmetic relevant chemicals into and through human skin using a standardized protocol." Journal of Applied Toxicology Chen, T., G. Lian and P. Kattou (2016). "In silico modelling of transdermal and systemic kinetics of topically applied solutes: model development and initial validation for transdermal nicotine." Pharmaceutical Research Water (mg) Diethanolamine (mg) 0.00E+00 2.00E+05 4.00E+05 6.00E+05 8.00E+05 1.00E+06 1.20E+06 1.40E+06 1.60E+06 1.80E+06 2.00E+06 -1 4 9 14 19 24 Concentration (ug/mL) Time (Hours) Concentration of Diethanolamine Concentration of Diethanolamine Max Solubility of Diethanolamine 0.00E+00 2.00E-03 4.00E-03 6.00E-03 8.00E-03 1.00E-02 1.20E-02 0 5 10 15 20 Volume (uL) Time (Hours) Volume Change of DIethanolamine 0.00E+00 2.00E+00 4.00E+00 6.00E+00 8.00E+00 1.00E+01 1.20E+01 -1 4 9 14 19 24 Amount (mg) Time (Hours) Change in Amount of Diet | poster |
Silvia Porporato1, Hamideh Darjazi1, Matteo Gastaldi1, Alessandro Piovano1, Giuseppina Meligrana1, Giuseppe A. Elia1, Claudio Gerbaldi1 1GameLab Group, Department of Applied Science and Technology, Polytechnic of Turin, Corso Duca degli Abruzzi 24, 10129, Turin, Italy Introduction • Large-scale energy storage systems are becoming fundamental for the modern society, particularly to fully exploit major advantages from renewable energy sources, such as wind and solar light. In this respect, secondary sodium-based batteries may represent the key technology since they possess high energy density, low-cost, simple design and easiness in maintenance. Nevertheless, the state of art of the current materials is rather far from a mass commercialization. Beside electrode materials, an essential role is also played by electrolytes and separators, which are deepened in this work. Indeed, many factors must be considered while selecting the best separator, including electronic insulation, low ionic resistance, mechanical stability, chemical resistance to degradation, wettability and uniform thickness [1]. • In this context, we prepared polyurethane-based membranes starting from polyviniyl butyral (PVB) and diisocyanate, by means of a coagulation bath [2,3]. • The choice of PVB as polymer is related to the European project SUNRISE, which aims to find different recycling pathways for this material, normally used as polymeric interlayer into laminated glasses for construction and automotive. At the moment, the PVB fraction collected after consume, that lacks of optical and mechanical requirements for its original purpose, is incinerated or landfilled, causing tons of losses every year, even though it could find a second life within the energy storage panorama [4]. Electrochemical impedance spectroscopy and plating and stripping processes were evaluated, to demonstrate the practical application of the developed materials in laboratory scale Li-based electrochemical cells at various conditions of current rate, temperature and aging. Preliminary results with dense membranes in combination with lithium are highly encouraging for future tests and measurements with sodium, paving the way to the development of more sustainable electrolytes separators for safe, low cost energy storage devices. Conclusions and future perspectives GPC analysis on commercial PVB: Mn (Average, Da) 15˙800 Mw (Weighted Average, Da) 135˙606 Polydispersity index 8 Porous Membrane Dense Membrane Membrane Preparation 4,4′-methylenebis (cyclohexyl isocyanate) H12MDI Solvent NMP 70 °C – 30 min Coagulation bath 1 h 1. Washing process Depending on the coagulation bath, two different materials can be obtained: Polyvinyl butyrral (PVB) Macroscopically identical, but microscopically and operationally diverse FESEM images 2. Drying at 40°C overnight OH concentration determination through IR using 2-ethyl-1-exanol for calibration curve in CHCl3 as solvent: 0.0172 mol OH in 1 g PVB (963 mg of equivalent KOH) 4000 3500 3000 2500 2000 1500 1000 500 0.00 0.05 0.10 0.15 0.20 PVB commercial Porous membrane Dense membrane H12MDI isocianate ATR (a.u.) Wavenumber (cm-1) 0 100 200 300 400 500 600 700 800 -16 -14 -12 -10 -8 -6 -4 -2 0 Derivative Weight Change (%/°C) T (°C) Commercial PVB Porous Membrane Dense Membrane Physico-chemical Membrane Characterization ATR-IR TGA References [1] Arora, P. et al., Chem. Rev., 2004, 104, 4419 [2] Lian, F. et al., J Memb. Sci., 2014, 456, 42 [3] Lv, Z. et al., Chemical Engineering Journal, 2022, 430 [4] F. Duffner et al., Renewable Sustainable Energy Rev., 2020, 127, 10987 [5] Porporato, S. et al., article under submission This work has received funding from the Italian Government (PRIN funding No 2017MCEEY4) and from the European Union's Horizon 2020 R&I program (grant agreements No 958243). 0 100 200 300 400 500 600 700 800 0 100 200 300 400 500 600 700 800 0 50 0 50 Z''/W OCV 5th cycle 10th cycle 15th cycle 20th cycle Z'/W 0 10 20 30 40 50 60 0 10 20 30 40 50 | poster |
ᚑᚌᚔLinkedOghamStones-SemantischeModellierung undprototypischeAnalyseirischerOgham-Inschriften Timo Homburg, Florian Thiery, Research Squirrel Engineers Einleitung CIIC 81, Macálister CIIC 81, UCC Beispiele von Ogham Wörtern Ogham Umschrift Übersetzung ᚋᚐᚊᚔ MAQI Sohn ᚋᚒᚉᚑᚔ MUCOI Stamm ᚉᚒᚅᚐ CUNA Wolf ᚉᚐᚈᚈᚒ CATTU Schlacht ᚐᚅᚋ ANM Name ᚐᚃᚔ AVI Nachfahre Die Ogham-Schrift ist eine in Irland und im westlichen Teil Britanniens (Wales und Schottland) anzutreffende antike Sammlung von Zeichen, welche überwiegend auf (Grab-)steinen zur Dokumentation von Namen der Verstorbenen, ihrer Verwandtschaften oder auch für kleinere Geschichten verwendet wurde. Nach der Entdeckung der Ogham-Schrift und der anschließenden Erstellung des Ogham-Alphabets datierte MacNeill einige der Ogham-Inschriften. Das wohl kompletteste Standardwerk findet sich in Macálister (1945, 1949). Dieser hat darin das weitverbreitete Nummerierungsschema CIIC etabliert. Das Ogham 3D Projekt scannt derzeit (155 Ogham Steine verfügbar) irische Ogham-Steine und stellt diese als Epidoc zur Verfügung. Semantische Modellierung in Wikidata Integrationsworkflow Wikidata Beispiel Wikidata Ogham Steine Nachdem die Informationen aus analogen Editionen extrahiert und mit Verweisen zu anderen Linked Data Ressourcen verlinkt wurden, können die Daten in Wikidata integriert werden. Hierzu werden die Tools ‘Open Refine‘ und ‘Quick Statements‘ genutzt. Mit der Integration in Wikidata ist nun die Grundlage geschaffen die angereicherten Daten mit Hilfe des SPARQL Unicorn zu verarbeiten. Somit sind weitergehende Analysen mit Open Source Software wie R oder QGIS mit dem ‘SPARQLing Unicorn QGIS Plugin‘ möglich. Analyse Oghamsteine in Irland Ogham Analysen Ogham Density Karte Wir stellen die Ogham-Steine als Linked Data bereit und ermöglichen somit deren Verarbeitung durch eine Reihe von Wissenschafts-Communities. Die Erfassung der Ogham-Steine als Linked Data Ressourcen erlaubt es, durch Verknüpfung von Wissen und dessen Anreicherung folgende Forschungsfragen anzugehen (1) Klassifikation von Steinen (2) Visualisierung von Zusammenhängen wie Verwandtschaftsbeziehungen (3) Formale Erfassung und maschi- nenlesbare Kodierung von Ogham-Zeichen. Als Datenbasis für die Analysen stützen wir uns auf eine Wikidata-Retrodigitalisierung des CIIC Corpus von Macálister (1945,1949), Epidoc-Daten des Ogham in 3D Projekts, sowie auf die Celtic Inscribed Stones Project (CISP) Datenbank. Des Weiteren pflegen wir aktiv fehlende und passende Elemente in Wikidata ein, um so später die Daten der Research Community im Sinne des SPARQL Unicorn bereitzustellen. Erste Extraktionsergebnisse zeigen zunächst die Clusterung der irischen CIIC Oghamsteine in Abbildung links, sowie die räumliche Verteilung von Beziehungen in Abbildung mitte und eine räumliche Vertelung in einer Density Map in Abbildung rechts. Weitere Informationen timo.homburg@hs-mainz.de rse@fthiery.de http://ogham.link | poster |
Kwon et al. (2018): Hypothetical reaction on discovery of microbial ETL tends to be positive Bains & Petowski (2021): Astrobiologist adjust probability assessment of ETL but not in a baysian way Routledge et al. (2017): Paranormal belief in ET satisfy the search for meaning Niklas A. Döbler and Claus-Christian Carbon University of Bamberg, Departement of General Psychology and Methodology Exopsychology and the human perspective on the extraterrestrial (mind) Contact: Niklas A. Döbler: niklas.doebler@uni-bamberg.de - https://orcid.org/0000-0001-7935-727X Exopsychology How do extraterrestrials think? Theoretically investigating cognition, behavior, affects, and motives of extraterrestrial agents How do we think extraterrestrials? Empirical focus on human beliefs, attitudes, and representations Exopsychology rejects the notion of intelligence due to the concept‘s inadmissible anthropocentric normativity. Yet, it acknowledges the importance of it when thinking and talking SETI and extraterrestrials Employs admissible over inadmissible anthropocentricism to generalize our condition to the stars but trades definitional acuity for applicability Extraterrestrial intelligence Extraterrestrials seen as: Methods N=75 persons (50F, 24M, 1 NA, MAge = 28.27) rated 54 pictures of cinematic depictions of ETs on different scales (1-5) Prediction of trustworthiness as central outcome Prior µ = 0, SD = 1 Findings Psychological similarity is more important than physical human-likeness Liking as strong positive, aggressiveness as strong negative predictor Intelligence plays subordinate role Limitations Comparability between images Missing values due to decision not to answer (M = 5.30%, SD = 0.54) High-cognitive Cognition as basic mental processes to organize, employ and utilize knowledge Continuum, inherent to every instance of life „Higher“ cognition: Thinking about thinking Meta-cognitive execution of behavioral and mental protocols and monitoring the outcomes Agents „Behavior governed by thought“[2] Purposefully interact and engage with the environment Download Döbler & Raab (2021): „Thinking ET – A discussion of exopsychology“[1] Implications SETI is first and foremost looking for higher cognition and agency – not plain intelligence Responsible for any technosignature, extraterrestrials must utilize their knowledge to purposefully adapt the environment to their demands Success of any first contact requires reciprocal psychological compatibility Mere engagement is not enough. Necessary skills and abilities, depending on socio-material and individual characteristics to exploit multiple relevant affordances must be present to engage with space research Organisms respond to relevant affordances to improve their grip on the situation and reduce an internal disequilibrium[3] Open questions: Which environmental and individual features bring forth relevant affordances for technology and space research? How can METI create a relevant affordance and evoke action readiness to respond? Which quality has the internal disequilibrium? Think about yourself: Why are you interested in space and its inhabitants? What do you need to pursue your research? One small step further Depending on physical attributes, abilities, and social- material environment of ET, a planet affords actions ET picks up affordances and creates behavioral outcomes detectable by SETI Planet may afford requirements for technologization, but ET does not have relevant skills and abilities or affordances lack relevance Planet does not afford actions necessary for space research Further research on how we think about ET Information from space exploration and SETI efforts. Edited to be understandable Hypothetical prevalence of extraterrestrial with overwhelmingly unknown characteristics. Information about our existence as cognitive agents in the universe Accessible information, limited by our physical position in the universe and technological and scientific | poster |
Main Outputs BE OPEN targets the promotion, regulation and standardization of Open Science in transport research through ➢ developing a framework of common understanding for realizing Open Science services that will provide technical interoperability, data and information interoperability and legal interoperability; ➢ developing the TOPOS forum and observatory for different stakeholders to support an evidence based dialogue; ➢ providing a roadmap and concrete guidelines for operationalizing Open Science services and guide key actors on how to adopt and adapt Open Science services in their research workflows; and ➢ designing a Code of Conduct for adopting them considering the main legal and security issues for their implementation. BE OPEN “European forum and oBsErvatory for OPEN science in transport” Caroline Almeras1 Afroditi Anagnostopoulou2 Maria Boile2 1 European Conference of Transport Research Institutes (ECTRI) 2 Centre for Research and Technology (CERTH)/ Hellenic Institute of Transport (HIT) caroline.almeras@ectri.org, a.anagnostopoulou@certh.gr, boile@certh.gr Abstract The BE OPEN “European forum and oBsErvatory for OPEN science in transport” project aims to create a common understanding on the practical impact of Open Science and to identify and put in place the mechanisms to make it a reality in transport research. Achieving Open Access to publications, making their underlying data FAIR (Findable, Accessible, Interoperable, Reusable) and open where possible, and using open and collaborative processes and infrastructure via the European Open Science Cloud (EOSC) are key factors in making transportation researchers share-reuse-reproduce science and in bringing such a critical sector closer to the society for enabling open innovation and citizen science. Openness, transparency, fairness, reproducibility of science are key aspects around which BE OPEN will seek to establish the ground rules for the transport research communities, ultimately establishing a community of transport research organizations willing to work on the basis of a commonly agreed “Open Science Code of Conduct”. To this end, BE OPEN has brought on board key transport and open science related communities in a two-fold action plan: to engage them in a participatory approach fostering a dialogue on Open Science (what exists, what should be done, how it should be done) among relevant stakeholders in Europe and around the world, and develop a detailed roadmap for the implementation of sustainable open science modules which include key practices, infrastructures, policies and business models, all taking into account the specificities of the transport research domain, and the use and integration of existing-infrastructures and the emerging EOSC initiative. Expected Impacts ❖TOPOS forum and observatory tools will contribute to creating a solid knowledge base on the implementation of Open Science approach in transport research ❖Governance and new operational/business models will be developed for enhancing Open Science by describing the rationale of how to create and capture value in economic and social context ❖The European Code of Conduct on Open Science in transport will be developed proposing recommendations and proper guidelines that allow setting up a community of transport research organizations ❖Awareness and visibility (authorities, Industrial and SMEs Associations in Transport, Publishing Companies, and the various European Technology Platforms, and strong media coverage) will be created ❖International stakeholders will be engaged in mutual learning and sharing experiences Objectives The BE OPEN project has received funding from the European Union’s Horizon 2020 Research and Innovation Programme under Grant Agreement No 824323. | poster |
Eine Analyse von Janos Borst, Manuel Burghardt, Vera Piontkowitz und Jannis Klähn, Computational Humanities. Kontakt: [nachname]@informatik.uni-leipzig.de Website: ch.uni-leipzig.de DHd-Konferenz – Postersession 26.02.2024 – 01.03.2024, Passau #Quo Vadis DH? 1. Jannidis, F., Kohle, H., & Rehbein, M. (Hrsg.). (2017). Digital Humanities: Eine Einführung. J.B. Metzler Verlag. 2. Blei, D. M., Ng, A. Y., & Jordan, M. I. (2003). Latent Dirichlet Allocation. Journal of Machine Learning Research, 993–1022. 3. McCallum, A. K. (2002). MALLET: A Machine Learning for Language Toolkit [Software]. http://www.cs.umass.edu/~mccallum/mallet 4. Rat für Informationsinfrastrukturen. (2016). Leistung aus Vielfalt: Empfehlungen zu Strukturen, Prozessen und Finanzierung des Forschungsdatenmanagements in Deutschland (S. 160). https://rfii.de/?p=1998 5. Sahle, P. (2013). Digitale Editionsformen. Zum Umgang mit der Überlieferung unter den Bedingungen des Medienwandels. Teil 1: Das typografische Erbe. [Finale Print-Fassung] (Bd. 7). BoD. 6. Wilkinson, M. D. et al. (2016). The FAIR Guiding Principles for scientific data management and stewardship. Scientific Data, 3(1), Article 1. 7. TEI Consortium. (2007). TEI P5: Guidelines for Electronic Text Encoding and Interchange. http://www.tei-c.org/Guidelines/P5/ 8. Moretti, F. (2011). Network Theory, Plot Analysis. Literary Lab Pamphlet, 2. Blei, D. M. (2011). Introduction to Probabilistic Topic Models. Communications of the ACM, 55. 9. Blei, D. M. (2011). Introduction to Probabilistic Topic Models. Communications of the ACM, 55. 10.Gius, E., & Jacke, J. (2017). The Hermeneutic Profit of Annotation: On Preventing and Fostering Disagreement in Literary Analysis. International Journal of Humanities and Arts Computing. DHD-TAGUNGEN 2014-2023 Wer mit wem? Ko-Autor:innenschafts-Netzwerk der Veröffentlichungen der DHd-Abstracts 2014 - 2023 2014 Passau 2015 Graz 2016 Leipzig 2017 Bern 2018 Köln 2019 Mainz/Frankfurt 2020 Paderborn 2021 vDHd 2022 Potsdam 2023 Luxemburg/Trier 2024 Passau 1 2 3 4 5 6 7 8 9 10 ! Die 10 meistzitierten Quellen in DHd-Abstracts (ausgenommen 2014 und 2015) 2014 fand die Tagung des Verbands „Digital Humanities im deutsch- sprachigen Raum“ (DHd) erstmals statt und hat sich seitdem zu einer aktiven Community entwickelt. Was genau in den letzten 10 Jahren passiert ist, fassen wir in dieser Informationsgrafik zusammen. Als Datengrundlage dienen 1.207 DHd- Abstracts aus den Jahren 2014 bis 2023 (mit Ausnahme von 2021). Die Daten wurden auf Basis folgender Forschungsfragen untersucht: • Wer sind zentrale Akteur:innen im Sinne von Publikationen, wer arbeitet mit wem zusammen? • Welche sind die großen DH- Standorte im deutschsprachigen Raum und wie haben sich diese im Laufe der Jahre entwickelt? Übersicht Berlin (155) Potsdam (58) Hamburg (68) Wolfenbüttel (30) Dresden (25) Leipzig (62) Paderborn (30) Köln (81) Trier (44) Mainz (47) FFM (33) Darmstadt (57) Würzburg (85) Erlangen (29) Regensburg (25) München (49) Stuttgart (62) Heidelberg (28) Göttingen (70) Wien (89) Graz (62) " # …und wo? Kartierung von DH-Standorten im deutschsprachigen Raum nach Publikationen auf DHd- Konferenzen $ ! " Anzahl der Publikationen der 10 DH-Standorte mit den meisten Veröffentlichungen bei der DHd zwischen 2014 und 2023 | poster |
WSY HERBARIUM- OUR DIGITAL FUTURE Mrs Mandeep Matharu1, Mrs Lydia Walles1, Mrs Sian Tyrrell1 1Royal Horticultural Society Gardens, Surrey, United Kingdom In 2011 with a capacity of 60,000 specimens, a herb scan and one staff member, the Royal Horticultural Society’s herbarium (now known as The 1851 Royal Commission Herbarium, and with the official abbreviation WSY) started its digitisation journey with the goal of creating a ‘Virtual Herbarium’. In the Winter of 2020-2021, amidst a pandemic, the team moved the collection to a state of the art facility based in our new building ‘RHS Hilltop – The Home of Gardening Science’. The new facility includes a space for 400,000 herbarium specimens in a temperature and humidity controlled environment and a digitisation suite with a high spec camera. All rooms within the herbarium suite have windows through which our visitors can glimpse into our fascinating collections and the herbarium’s curation and research work. With around 90,000 (and growing) digitised specimens, thanks in part to sponsorship by the Society’s members, the 1851 Royal Commission, the Mellon Foundation and the National Lottery Heritage Fund, the herbarium is ready to share the world’s largest ornamental plant collection with a wider audience through the Libnova Open Access online portal. The RHS has adopted the Libsafe digital preservation platform for the long-term preservation and public sharing of its digital herbarium and library collections. This new platform will safeguard the digitised herbarium specimens and their metadata in a cloud based solution whilst allowing the team to share specially curated collections and themed sets with the public alongside items from the RHS’s botanical art, photography and library collection | poster |
High Throughout Assay Development with Raphidocelis subcapitata K. Bush1, M. Le1, E. Stacy1, D. Villeneuve2, K. Flynn2 1. Oak Ridge Institute for Science and Education, Great Lakes Toxicology and Ecology Division 2. US EPA, ORD, Center for Computational Toxicology & Exposure, Great Lakes Toxicology and Ecology Division Duluth, MN Background The U.S. Environmental Protection Agency (USEPA) is tasked with assessing the impacts of market chemicals on ecosystems using standardized tests across a diverse range of organisms. To support a new paradigm in toxicity testing, EPA has envisioned a tiered framework for hazard characterization that employs high throughput and high content assays as a first-tier screen, followed by successive progression to more targeted and resource intensive tests where warranted (Thomas et al. 2019 ). To date, assay development under this new testing paradigm has largely focused on human health, with limited or no capacity to detect hazards associated with compounds that are uniquely toxic of primary producers like plants and algae. The aim of the present study was to adapt traditional algal toxicity assays to a high throughput and high content (through the incorporation of transcriptomics-based endpoints) format could be incorporated into EPA’s next generation blueprint for computational toxicology. Objective Develop, optimize, and evaluate a high throughput, transcriptomics-based toxicity test with the green algae Raphidocelis subcapitata (RS), currently used in a standard test guideline (OSCPP 850.4500). The present poster reports on a 96-well plate 24-hour RS assay using lab automation that yields a large amount of data that can be used to determine multiple endpoints. Methods • 3, 1-mL, 96-well plates were loaded with algae from a 5.0x106 cells/mL stock • Plates were centrifuged to pellet algae • Plates were placed on the Biomek i5 liquid handling automated workstation to remove media and expose to 600 uL of exposure media Each plate had 2 chemical exposures, 8 concentrations of each with 5 reps 30 mM and 9.5 mM CuSO4 were used as positive controls on each plate Biomek programmed to avoid unbalanced treatment along edges using the following predetermined randomized layout: • Exposed algae were resuspended and left on a shaker under constant light for 24 hours • After 24 hours algae was pelleted as before • One plate was frozen for RNA extraction and exposure media sampled for chemical quantification • The 2nd plate was used for apical observations Cell count, photopigments, and a fluorescence-based cytotoxicity assay all read using a fluorescence plate reader (BioTek Synergy Neo2) • The third plate was used as a backup • Apical observation data was run through the dose-response software BMDExpress2 to calculate an EC50 after being derandomized in Excel Results Growth The following results are based on three example chemical exposures across three chemical classes. EC50s were calculated based on growth data and compared to those reported in the ECOTOX database. *Computed EC50 larger than highest concentration **Studies were conducted 2+ days rather than 1 Resulting EC50s were higher than those reported for studies conducted over multiple days in different formats than 96 well plates. Cell count relative to time 0 (growth): The growth response data showed that BPA had little to no impact on growth, nonylphenol increased growth at higher concentrations, and sertraline decreased growth at higher concentrations. Going Forward • Chemical quantification Plate used for storing exposure media will be switch to glass containment to avoid chemical absorbing into plastic. Current exposures have resulted in concentrations being much lower than nominal. Efforts are ongoing to model chemical distribution to media, plate well walls, and/or algae • Increasing initial algal cell number in exposure plates might be necessary to obtain enough RNA for downstream transcriptomics Methods for RNA extraction are cu | poster |
BioSharing works to map the landscape of community developed content standards, ensuring they are registered, informative and discoverable, monitoring their: development, evolution and integration; implementation and use in databases; and adoption by data policies by funders and journals. Progressively, BioSharing will monitor the maturity of content standards, collecting metrics of usage, and the level of endorsement. BioSharing is also being further developed as content- provider for standards-driven metadata templates for data collection and curation. BioSharing works to serve those seeking information on existing standards and databases, and to identify areas where duplications or gaps in coverage exist, promoting harmonization to avoid wasteful reinvention. Team Funded By Philippe Rocca-Serra Eamonn Maguire Alejandra Gonzalez-Beltran Milo Thurston Susanna-Assunta Sansone STANDARDS & DATABASE DEVELOPERS & MAINTAINERS FUNDERS, JOURNAL EDITORS & LIBRARIANS RESEARCHERS, TOOL DEVELOPERS & CURATORS e.g. seek guidance to find data- bases that implement standards to deposit their data; or identify appropriate data standards to be implemented in an annotation tool e.g. gather enough infor- mation to make informed decisions on which content stand- ards should be funded, implemented or recom- mended in their policies A catalogue of data preservation, management and sharing policies from international funding agencies and regulators. Call for collaborators If you have catalogues you would like us to link to, contact us. A catalogue of reporting standards and organizations that develop these. Partly compiled by linking to A catalogue of databases, described according to the BioDBcore guidelines, along with the standards used within them. Partly compiled with the support of NAR Database Issue and DATABASE journals User profiles Faceted search Database Details Standard Details a web-based curated and searchable registry of content standards, databases and policies in the life sciences e.g. need a central place to register their work, claiming ownership and getting credit; make standards visible and re-usable Advisory Board and RDA working group members Jessica Tenenbaum (Duke University, USA), Co-Chair of the Advisory Board Melissa Haendel (OHSU, USA; Force 11; Monarch Initiative), Co-Chair of the Advisory Board Susanna-Assunta Sansone (University of Oxford, UK; NPG Scientific Data), Co-Chair of the RDA WG Simon Hodson (CODATA), Co-Chair of the RDA WG Rebecca Lawrence (F1000), Co-Chair of the RDA WG Michael Ball (BBSRC) Theo Bloom (BMJ) Jennifer Boyd (OUP) Scott Edmunds (GigaScience, BGI) Rafael Jimenez (ELIXIR) Amye Kenall (BMC) Varsha Khodiyar (NPG) Thomas Lemberger (EMBO Press) Jennifer Lin (PLoS) Jonathan Tedds (Ubiquity Press Open Health Data Journal, University of Leicester, UK) Todd Vision (UNC Chapel Hill & NESCent, USA) Michael Witt (re3data, Purdue University Libraries) Communities (see more on the website) | poster |
Increasing Open Source Collaboration for Better Scientific Code Open Source Collaboration in Python for CDF files - The Shared Attribute and Metadata Management Interface (SAMMI) Project Standards for open source Maxine Hartnett¹, Andrew Robbertz², Damian Barrous-Dume³, Matthew Bourque¹, Tenzin Choedon¹, Steven Christe⁴, Luisa Croakley¹, Sean Hoyt¹, Nat Kerman¹, Greg Lucas¹, Ana Manica¹, Tori Marbois¹, Veronica Martinez¹, Tim Plummer¹, Daralynn Rhode¹, Laura Sandoval¹ Contributions are made Contributions are made back into the open source project, as users find bugs or develop new features Code is made open source Code is made publicly available, with documentation and other tools for easy use Code is used Projects find open source code that addresses unsolved problems The Cycle of Open Source What is SAMMI? Why did this work? Design and Usage The Shared Attribute and Metadata Management Interface (SAMMI) is an open source Python library for managing ISTP (International Solar-Terrestrial Physics) CDF attributes. The tool uses YAML files to assign metadata to CDF variables, making it easy to track data attributes in version control software next to Python processing code. It also validates variables against the ISTP metadata standards. SAMMI is lightweight and extensible, making it usable for a variety of project needs. The YAML files are human and machine readable, so they’re easy to update and read for non-technical users. YAML also provides a tools for creating default values for attributes, reducing duplicated information. An example file for the global attributes of IMAP SAMMI solves a common problem for projects which are required to produce ISTP CDF files. These files all follow the same requirements and standards, but there wasn’t a publicly available way to manage attributes in version control software. Both the NASA Space Weather Science Operations Center (SWxSOC) and the IMAP Science Data Center (SDC) were independently developing similar systems for solving the problem when members from both teams attended the Workshop for Collaborative and Open Source Science Data Systems at LASP. Since SWxSOC had their code open source, it was easy to identify the shared piece of work. Both teams collaborated to take the initial iteration of the attribute management system and make it a separate library that was flexible enough for both projects to use. Today, both projects depend on the shared SAMMI repo and contribute new features. Code reviews, contribution guidelines, and automatic testing make contributing back easy. License, documentation, and consistent releases make code useable. Code style, good code design, and documentation make projects easier to modify. Standards for open source repositories help create tooling that can be widely used and modified. The most important and, luckily, the simplest, is the license on the code. Without a license attached to open source code, no one else is legally able to use it. Also key is documentation. Without documentation, people would need to read your code to learn how to use it and why. At minimum, projects should include a short description and some basic usage and installation instructions. However, the more documentation, the better. The best open source projects have extensive documentation and large communities that can teach new users about the tool. Finally, tools that ensure code quality are great to have in an open source repository. High quality code is more reliable, easier to modify, and therefore less risky to adopt. Some tools that we use in the SAMMI repo are: ●Required code reviews ●Automatic releases ●Automatic unit tests ●Pre-commit tools to enforce a consistent code style How do you create tools that other people can actually use? 1. Use a license 2. Make the tool easy to use through documentation and good design 3. Create a reliable tool through regular releases and code reviews Using an open source project introduces some unavoidable risk. As a developer, reducin | poster |
Ethan James1, Michael Ha1, Citlali Aguilera-Rico1, Anna Howell1, Karen Cusato1 and M. Natalia Vergara1,2,3 1CellSight Ocular Stem Cell and Regeneration Program, Sue Anschutz Rodgers Eye Center, University of Colorado School of Medicine, Aurora, CO 80045, 2Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, 3University of Colorado Alzheimer's and Cognition Center, University of Colorado School of Medicine. Aurora, CO 80045 Alzheimer’s Disease Neuropathology in the Human Trisomy 21 Retina Introduction Methods Acknowledgements Conclusions We would like to thank the following benefactors whose support made our research possible: Contact: ethan.james@colorado.edu Results 1) Increased AD histopathology in donor retinas from individuals with DS 2) DS hiPSC can generate ROs with all major retinal cell types 3) DS ROs exhibit phosphorylated Tau pathology 4) DS ROs exhibit amyloid-β pathology 5) Fluorescence-based assay for the quantitative assessment of amyloid plaques in ROs • Down syndrome (DS) results from an extra copy of chromosome 21, causing genetic imbalance and affecting brain development, leading to intellectual disabilities. • Individuals with DS face a heightened risk of Alzheimer's disease (AD), resulting in accelerated formation of amyloid plaques and neurofibrillary tangles in the brain and retina. • Human induced pluripotent stem cell (iPSC)-derived retinal organoids (ROs) offer a promising avenue for studying AD- related changes specific to DS, providing insights into retinal pathology and potential biomarkers for early diagnosis and interventions. CTR D21 T21 AT8/DAPI T231/DAPI A B C D E F CTR D21 T21 4G8/DAPI NIAD/DAPI 4G8/NIAD/DAPI A B D E G H C F I *** * CTR DS 4G8/DAPI 6E10/DAPI A C E B D F T231/DAPI NIAD/DAPI G H E I J Figure 3: (A-H) Comparison of AT8 (A-C) and T231 staining (D-F) targeting different phosphorylation sites of pTau, (G) quantification of average relative stained area for pTau (n=5, p<0.001***), (H) protein quantification by Western blot for pTau in human DS retinas (n=2) and a control retina (p<0.05*), error bars show SEM Figure 4: (A-K) Comparison of 4G8 staining for Aβ (A-C), NIAD staining for amyloid plaques (D-F), and colocalization (G-I). (J) Quantification of average relative stained area for Aβ (n=5, p<0.001***). (K) Percent of 4G8 colocalized with NIAD, indicative of dense core plaques. CTR D21 RCV/DAPI Otx2/DAPI A C E B D F AP2α /DAPI PROX1/DAPI G H E HuC/D/DAPI I J Figure 2: (A-J) (A-B) Recoverin (RCV) staining for photoreceptor cells, (C-D) Otx2 staining for photoreceptor cells, (E-F) PROX1 staining for horizontal and amacrine cells, (G- H) AP2α staining for amacrine cells, (I-J) HuC/D staining for ganglion cells Figure 1: (A-H) (A-B) 4G8 staining for Aβ, (C-D) 6E10 staining for Aβ , (E-F) NIAD staining for amyloid plaques, (G- H), T231 staining for phosphorylated Tau (pTau) J K G H *** Figure 5: 3D Automated Reporter Quantification (Vergara et al., 2017) of NIAD-4-stained whole-mount 3D retinal organoids shows a statistically significant increase in NIAD-4 fluorescence in DS organoids compared to controls. Hoescht staining was used for size normalization. * p<0.05. *** *** • Our study confirms the presence of AD histopathology in the human retina of individuals with DS. • Development and characterization of the first RO model of human T21 provide a valuable tool for studying the relationship between DS and AD within the context of the retina, offering new avenues for therapeutic interventions and biomarker discovery. • Utilizing human iPSC-derived ROs allow us to recapitulate AD- related changes, including Aβ deposition and pTau, providing a platform for investigating the underlying molecular mechanisms and potential therapeutic targets. CB DS | poster |
Assisted Text Annotation Using Active Learning to Achieve High Quality with Little Effort Franziska Weeber∗, Felix Hamborg†, Karsten Donnay‡† and Bela Gipp§ ∗University of Konstanz, Germany, †Heidelberg Academy of Sciences and Humanities, Germany, ‡University of Zurich, Switzerland, §University of Wuppertal, Germany franziska.weeber@uni-konstanz.de Abstract—Large amounts of annotated data have become more important than ever, especially since the rise of deep learning techniques. However, manual annotations are costly. We propose a tool that enables researchers to create large, high-quality, annotated datasets with only a few manual annotations, thus strongly reducing annotation cost and effort. For this purpose, we combine an active learning (AL) approach with a pre- trained language model to semi-automatically identify annotation categories in the given text documents. To highlight our research direction’s potential, we evaluate the approach on the task of identifying frames in news articles. Our preliminary results show that employing AL strongly reduces the number of annotations for correct classification of even these complex and subtle frames. On the framing dataset, the AL approach needs only 16.3% of the annotations to reach the same performance as a model trained on the full dataset. Index Terms—active learning, deep learning, Longformer, text classification, data annotation I. INTRODUCTION AND RELATED WORK With the rise of machine learning and recently deep learn- ing, annotated data have become more important than ever before. While traditional machine learning relies mostly on handcrafted rules and features, recent approaches use large amounts of annotated data. Not only computer scientists rely on these extensive labeled corpora, they are also needed in other disciplines, e.g., for the large-scale analysis of media bias in political science, genome diagnostics in the medical and biological sciences, and other practical applications such as online customer support bots. Large amounts of unlabeled data are available for most tasks, but creating the annota- tions needed to use them as training sets is costly [4]. A solution is active learning (AL), where a classifier is trained over multiple iterations by querying batches of only those instances for manual annotation from a large unlabeled pool that are considered most informative for the model [4]. AL can substantially reduce the number of labeled observations needed to classify the full pool, especially when classes are unbalanced because the minority class will be overrepresented in the queried training data [4], [6]. The AL process is structured into two phases: seed set se- lection and iterative query selection plus training. During seed set selection, the initial training set is chosen, e.g., randomly, manually, or based on other criteria such as seed words or cluster membership [6]. Humans label these instances, and then the model is trained on them. In query selection, each iteration entails: predicting the class probabilities for the data pool, querying new instances for labeling, and retraining the model. The first task aims to determine which instances to query for labeling next using a measure of informativeness, e.g., the uncertainty of the prediction. Afterward, the classifier is retrained on the updated labeled set until a performance threshold is reached or a predefined number of texts have been annotated [6]. Previous work on semi-automated data annotation employ- ing AL suffers from the following shortcomings: (1) super- ficial or poor results and (2) lack of easy-to-use annotation interfaces. First, prior methods using AL often use outdated methods, such as bag of word representations and SVMs [5], [6], not reaching the performance of language models such as BERT or its successors. Second, most approaches do not provide an interface for the annotation [5] or still require users to have programming experience [3]. Despite these shortcomings, the usefulness | poster |
U.S. Environmental Protection Agency Office of Research and Development EPA www.epa.gov Development of QSAR Models for Systemic Toxicity Points of Departure with Variability in Experimental Data Prachi Pradeep1,2 and Richard Judson2 1Oak Ridge Institute for Science and Education, Oak Ridge, Tennessee 2National Center for Computational Toxicology, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina INTRODUCTION TYPES OF MODELS DATA PREPARATION METHODS Prachi Pradeep l pradeep.prachi@epa.gov l ORCID iD: 0000-0002-9219-4249 l Phone: 919-541-5150 CONCLUSIONS Human health risk assessment associated with environmental chemical exposure is limited by the tens of thousands of chemicals with little or no experimental in vivo toxicity data. Data gap filling techniques, such as quantitative structure activity relationship (QSAR) models based on chemical structure information, are commonly used to predict hazard in the absence of experimental data. However, variability in the experimental data leads to uncertainty in QSAR model predictions and impacts model quality estimates. This study presents three sets of QSAR models developed for systemic toxicity in vivo points of departure (POD, the point on the dose-response that marks the beginning of a low-dose extrapolation). The in vivo data is taken from the EPA’s ToxValDB, a compilation of information on ~3000 chemicals from a variety of public data sources. The first set of QSAR models were developed and evaluated to predict point estimates of POD values using structural and physicochemical descriptors. The second set of models were built to account for skewness in the training data. The third set of models were built to account for the known lab to lab variability in experimental POD values. The QSAR models were also evaluated for enrichment of most potent chemicals. These models will inform chemical screening and prioritization efforts. • Point-estimate model results demonstrate that independent study type and species combinations did not result in significantly better models than combining the data for all the classes and species together. - The RMSE for the all the models are within the variance in the underlying POD data (Figures 2 and 6). - Enrichment analysis results demonstrate the utility of these models for chemical screening and prioritization efforts. • Point-estimate with balanced dataset model results show improvement in the training set results but did not show improved results on the external test sets. • Point-estimate with confidence interval models presented a technique to estimate uncertainty associated with model predictions. The results demonstrate the impact of variability in training data (experimental POD) on uncertainty associated with model results. Disclaimer: The views expressed are those of the authors and do not necessarily reflect the views or policies of the U.S. Environmental Protection Agency. 1. Point-estimate Models • A single POD value predicted for each chemical. • Experimental POD = Median POD value from all studies. 2. Point-estimate with Balanced Dataset Models • Training data re-constructed to reduce skewness. • A single POD value predicted for each chemical using the re-constructed data. The process was repeated 1000 times. • Experimental POD = Median POD value from all studies. 3. Point-estimate with Confidence Interval Models • A POD distribution was constructed for each chemical (µ = Median experimental POD value from all studies, σ = 0.5 log-units). • 1000 bootstrap models were built with random sampling of POD values for each chemical from the pre-generated POD distribution. • Predicted POD = mean of 1000 bootstrap predictions • Confidence interval of POD = ±1 standard deviation of 1000 bootstrap predictions Given the variability and skewness in the training dataset, 3 types of models were developed: Study Type Species Total number of POD values (studies) Number of unique chemicals | poster |
Integrating Fragmented Scientific Knowledge Prashant Gupta, Mark Gahegan and Gillian Dobbie Centre for eResearch, Department of Computer Science, University of Auckland {p.gupta, m.gahegan, g.dobbie}@auckland.ac.nz Making sense of disconected data, methods, models and workflows Key efforts to aggregate scientific knowledge, as shown below, focus on the reproducibility of a single experiment, whereas we focus on integrating science as an ongoing and evolving process. All of these systems integrate data and methods but ignore conceptual structures and thus provide a mechanistic view of science, rather than as a dynamic and cyclic process of evolution. Research Executable Workflow Linked Data/ Object [1] Paper [2] Systems [3] Science [4] Research Question: How do we restore the connections among scientific artifacts, that are often evident in the mind of a researcher, in our digital representations to present an integated view of scientific knowledge? Scientific knowledge which is usually well connected in a knowledge producer’s mind is often fragmented by various computational tools into individual artifacts - data, methods, code, schema and workflows - with no explicit connections. Reusing Carole’s experiment. Bill tried to use Carole’s work to compare land cover categories in NZ and Australia. He had a hard time making sense of her work because of the lack of details of the process and the decisions made. Knowledge consumer having a hard time understanding another researcher’s work. Carole’s experiment. Carole synthesized land cover categories (e.g. forest and water) and built a land cover map for NZ and published the map using an online mapping tool without any details of the process. Science digitization misplaces knowledge The state of knowledge integration in science 1. S. Bechhofer, D. De Roure, M. Gamble, C. Goble, and I. Buchan, “Research objects: Towards exchange and reuse of digital knowledge,” presented at The Future of the Web for Collaborative Science, NC, USA, 2010. 2. J. P. Mesirov, “Accessible reproducible research,” Science, vol. 327, pp. 415–416, Jan. 2010. 3. T. Kauppinen and G. M. Espindola, “Linked open science communicating, sharing and evaluating data, methods and results for executable papers,” presented at the Int. Conf. Computational Science, 2011, pp. 726–731. 4. E. Deelman, D. Gannon, M. Shields, and I. Taylor, “Workflows and e-Science: An overview of workflow system features and capabilities,” Future Generation Computer Systems, vol. 25, pp. 528–540, May 2009. In contrast, this work focuses both on data and conceptual structures, such as categories and models, and allows them, and the connections among them to change and evolve over time, making them dynamic and live. Integrated and live approach to science We propose a conceptual model (cloud in the figure below) to ensure that data, methods, categories and schemas stay connected and co-evolve during the conduct of research. We created a computational tool – AdvoCate – that implements this model and facilitates the modeling of scientific categories, integrates various artifacts (using semantic technologies - RDF), remembers their details and versions, and analyzes and mediates change information among them. Live connections that allow change information to mediate from one scientific artifact to another using semantic technologies (RDF) The model remembers the research that Carole performs by connecting various scientific artifacts - data, categories and map - and recording their details while the experiment is done. Bill can now explore these connections to make sense of Carole’s work, and use them to compare NZ and Australia land cover maps. Conclusion: This work supports an integrating and live approach towards scientific knowledge, connecting scientific artifacts of an experiment and synchronizing them with the practice of science, which supports a deeper and clearer understanding and communication of scientific research. References | poster |
Nitrogen fractionation across the Galaxy Observations of the 14N/15N ratio in a large sample of high-mass star-forming cores L. Colzi1,2, F. Fontani2, V. M. Rivilla2, A. Sánchez-Monge3, L. Testi2,4, M. T. Beltrán2, P. Caselli5 1 Università degli studi di Firenze, Dipartimento di Fisica e Astronomia, Via Sansone, 1 - 50019 Sesto Fiorentino (Italy); 2 INAF-Osservatorio Astrofisico di Arcetri, L.go E. Fermi 5, I-50125 Firenze (Italy); 3 I. Physikalisches Institut of the Universität zu Köln, D-50937 – Cologne (Germany); 4 European ALMA Programme Scientist - ESO, Karl Schwarzschild str. 2, D-85748 Garching (Germany); 5 Max-Planck-Institute for Extraterrestrial Physics, Giessenbachstrasse 1, D-85748 Garching (Germany) Introduction 15N is the less abundant stable isotope of nitrogen and is enriched in comets and carbonaceous chondrites with respect to the value measured in the Protosolar Nebula (PSN) (Marty et al., 2010), but we still do not understand if this enrichment is a heritage of the past chemical history. Because our Sun was born in a rich cluster, possibly including massive stars (e.g. Adams 2010), observations of massive, dense star forming cores in different evolutionary stages, and in a statistically significant sample, are needed. Sample and observations - LINES: HN13C, H13CN, HC15N, H15NC (J=1-0) with the IRAM- 30m Telescope; - SOURCES: 87 high-mass star forming cores: 27 of these sources belong to the three main evolutionary categories of the high-mass star formation process (Colzi et al., 2017). This sample has been recently increased with 60 massive dense cores and do not have an evolutionary classification yet (Colzi et al., in prep). 1) 15N-Fractionation - 14N/15N 180-555 from HNC - 14N/15N 115-810 from HCN - Asymmetric distributions peaked around values <440 2) Galactocentric gradient With linear fit: HCN/HC15N = 21±9 kpc−1 × DGC + 250±67 HNC/H15NC = 20±6 kpc−1 × DGC + 221± 42 Consistent with that found by Adande & Ziurys (2012). 3) Comparison with models Non-Parametric fit can not reproduce the flattening trend of the Galactic Chemical Evolution model made by Romano et al. (2017) for DGC > 8 kpc. NEEDED MORE OBSERVATIONS IN THE OUTER GALAXY… BASED ON A LARGE STATISTICS!! References: Adams 2010, ARA&A, 48, 74 Adande & Ziurys 2012, ApJ, 744,194 Colzi et al., 2017, arXiv:1709.04237 Marty et al.: Geochimica et Cosmochimica Acta74, 340-355, 2010 Romano et al. 2017, MNRAS, 470, 401 | poster |
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