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How accurate are facial technologies ? How does face verification work? Facial technology AI systems are trained on big datasets. Despite their size, these datasets often lack the variety of genders and skin tones we can observe in real life, caus- ing the system to be less accurate for some people. Studies show that those with intersec- tional identities are especially affected. These two key errors reduce accuracy light medium dark OK <Same> dataset average dataset average Intersectional qualities magnify biases in algorithms Intersectionality noun The theory that people who have multiple social identities, like race, gender, sexuality, and class, that are different from the norm often experience combined systemic oppression and discrimination. Face verification is used to confirm that the person in the document is the same as the one present. For this, it needs a still image of the face and a new photo taken on the spot. Step 1. Step 2. Step 3. Step 4. Step 5. AI detects the faces in the images. It compares the size and distance of facial features. It decides if the faces are similar enough to be considered the same. By analyzing facial features, AI translates the data into information it can calculate with. [ in-ter-sek-shuh-nal-i-tee ] gender nationality socioeconomic status class sexual orientation race the ‘norm’ deviation from the ‘norm’ MAMMOth Project – Grant ID 101070285] Co-funded by the European Union. Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or European Commission. Neither the European Union nor the granting authority can be held responsible for them. Scan the QR code to see the references for this material. This poster was designed by Dali is a science communicator. Their expertise is in the field of AI ethics and biases. They enjoy creating and curating memorable experiences for a variety of audiences. Dali Fekete (he/she/they) linkedin.com/in/dalifekete Cristina is a graphic designer and science communicator. She combines her passion for science with her passion for art, creating wonderful illustrations, infographics, and other visual materials for scientific dissemination. Cristina Pop cristinapop.ro linkedin.com/in/cristinapopscicomm AI Biases in Face Recognition Facial technologies rely on AI algorithms to detect, recognize, verify, and identify people in photographs and videos. While it may sound sci-fi, these technologies are already used by companies and governments for face verification. KO <Different> The chance that AI will incorrectly allow access to an unauthorised person. False Acceptance Rate False Rejection Rate The chance that AI will wrongly deny access to a legitimate user. light medium pimples scars surgeries accidents ageing medication & serious illnesses dark AI systems often struggle to understand these differences, which then reduces the accuracy of correct verification. This shortcoming can affect everyone, regardless of their (intersectional) characteristics. All faces change over time INTERNATIONAL PASSPORT P<NLRUGCLT<<CRISTINA<POP<<DALI<FEKETE<<<<<<<<<<<<<<<<< 04062024<<DSEC<<M4D3W1THL0V3<<<<<<<<<<<<<<<<<<<<<<<< VIDEO PHOTO PORTRAI VIDEO PHOTO PORTRAI INTERNATIONA P<NLRUGCLT<<CRISTINA<POP<<DALI< 04062024<<DSEC<<M4D3W1THL0V3<< Darker female Darker male Lighter female Lighter male Microsoft Face++ IBM Amazon Kairos 20.8% Face Recognition Technology Difference between lowest and highest accuracy Accuracy (%) 33.7% 34.4% 31.4% 22.5% gender race religion Skin tone & gender Dark-skinned women who wear religious head coverings like scarves and hijabs face three challenges: their skin tone, their gender, and their apparel. The accuracy score is calculated by the ratio of correct and incorrect AI decisions. Incorrect decisions are often disproportionately large for intersectional communities in comparison to ‘the norm’, as shown in the chart below. 100110101010 100101101010 001110010101 010101000101 100110101010 1001 | poster |
Introduction In Xenopus laevis oocytes an absence of transcription occurs in early development from before the resumption of meiosis in stage VI oocytes, through the maternal-zygotic transition (MZT) at almost 4000 cells, requiring new protein synthesis to be directed by stored mRNAs. Several modifications control the translation of these mRNAs including cytoplasmic polyadenylation and 2’-O methylation1. Mechanics of cytoplasmic polyadenylation are well established, but 2’-O methylation involvement is less clear. We are interested in the mechanism through which this modification might act in regulation of translation and are investigating candidate proteins that recognize the presence or absence of this molecular mark. The interferon induced with helicase C domain 1 (Ifih1 or Mda5) protein is known to bind RNAs based on their 2’-O methylation state2. The ifih1 transcript has been identified in the stage VI oocyte, implying possible involvement in oocyte maturation, and suggesting that the Ifih1 protein could be involved in translational regulation. An alternative function may be in developmental immunology as Ifih1 is typically responsible for recognition of dsRNA and the activation of cytokines. Little is known regarding immune responses during early Xenopus embryogenesis, but as Ifih1 is known to target (+) ssRNA viruses, such as coronaviruses, determining the role of Ifih1 in Xenopus laevis development may help better understand the protein’s overall function. Discussion While research was halted due to the University shutdown, we have indication that we have cloned the ifih1 mRNA, and have the PIV5-V ready for transcription and injection. The following considerations are guiding our experimental design: • Ifih1 usually acts through the Mavs protein to activate interferon and cytokine transcription in response to viral infection3. If it is acting as an immune sentinel it will activate through a novel mechanism as there is no transcription at this stage • The other RLR do not seem to be expressed in early development suggesting a different developmental role for this protein • There is precedence for helicases such as Ifih1 to act as regulators of translation7 • Isolation of tagged Ifih1 and binding partners, (protein and mRNA) should establish the pathway that the protein is acting in during development Elizabeth C. Devaney, Serena Iacovelli, Morgan Nelson, & Daron C. Barnard Department of Biology, Worcester State University Functional Characterization of Ifih1 and Dhx29 During Early Xenopus laevis Development Literature cited 1. Kuge, H., & Richter, J. D. (1995). Cytoplasmic 3“ poly(A) addition induces 5” cap ribose methylation: implications for translational control of maternal mRNA. The EMBO Journal, 14(24), 6301. 2. Züst, R., et al. (2011). Ribose 2′-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5. Nature Immunology, 12(2), 137–143. 3. Dixit, E., and Kagan, J. C. (2013). Intracellular Pathogen Detection by RIG-I- Like Receptors. Adv Immunol. 117, 99–125 4. Xenbase (http://www.xenbase.org/, RRID:SCR_003280) 5. Session, A.M., et al. (2016). Genome evolution in the allotetraploid frog Xenopus laevis. Nature 538, 336-343. 6. Ramachandran, A. and Horvat, C.M. (2010). Dissociation of Paramyxovirus Interferon Evasion Activities: Universal and Virus-Specific Requirements for Conserved V Protein. J. Virol., 84 (21): 11152-11163. 7. Bourgeois, C. F., Mortreux, F., and Auboeuf, D. (2016). The multiple functions of RNA helicases as drivers and regulators of gene expression. Nat Rev Mol Cell Biol, 17, 426-438. Acknowledgments The authors would like to thank Worcester State University for the Faculty Scholarship and Creativity grant awarded to DCB to fund the research, the Office of University Advancement for the Student Research, Scholarship & Creativity Activity grant awarded to ECD to attend the 2020 TAGC, and Xenbase for the available Xenopus resources. O | poster |
Detecting immunological synapses through analysis of Imaging Flow Cytometry data Bram van den Broek1, Rolf Harkes1, Anita Karomi2, Christina Metoikidou3, Sofía Ibañez Moleroo2 1 BioImaging Facility, The Netherlands Cancer Institute, Amsterdam 2 Functional Oncogenomics, The Netherlands Cancer Institute, Amsterdam 3 Precision Cancer Immunotherapy, The Netherlands Cancer Institute, Amsterdam b.vd.broek@nki.nl ImageStream Analysis Immunological synapses are transient structures formed at the interface between lymphocytes and antigen-presenting cells. Too assess the efficacy of cancer immunotherapy responses, we present a bioimage analysis workflow for quantifying cell interactions and identifying immune synapses in cancer patient samples using Imaging Flow Cytometry (IFC). IFC acquires brightfield and fluorescence images of cells as they pass through the analyzer/sorter, and provides an opportunity too capture cellular interactions in large samples. Overcoming the limitations of the existing proprietary analysis software, we preprocess and merge exported tiff files intoo multichannel image stacks and employ Fiji scripting for in-depth image analysis. By combining several open -source components (Cellpose, CLIJ2) the integrated workflow allows for automated cell segmentation based on fluorescence markers and brightfield images, classification of various immune and tumor cell types, detection and quantification of cell-cell interfaces, and assessment of marker enrichment at immune synapses. Imaging Flow Cytometry Outlook Powered by References Abstract • Use more clusters too directly identify all cell types • Membrane enrichment analysis for 3 or more cell types [1] https://github.com/BioImaging-NKI/ImageStreamCombiner [2] https://github.com/BioImaging-NKI/ImageStreamAnalysis [3] Schindelin, J., Arganda-Carreras, I., Frise, E. et al. Fiji: an open-source platform for biological-image analysis. Nature Methods 9(7), 676–682 (2012). [4] Stringer, C., Wang, T., Michaelos, M., & Pachitariu, M. Cellpose: a generalist algorithm for cellular segmentation. Nature methods, 18(1), 100-106 (2021). [5] Haase, R. et al., CLIJ: GPU-accelerated image processing for everyone. Nature Methods 17, 5-6 (2020). [6] Legland, D., Arganda-Carreras, I., Andrey, P., MorphoLibJ: integrated library and plugins for mathematical morphology with ImageJ. Bioinformatics 32(22), 3532-3534 (2016). Existing software does not detect whether cells are touching/interacting. Goal: framework for characterizing immune cell-tumor interactions • Identify different immune cell types • count interactions between all cell types • Quantify immune marker enrichment at T cell – tumor interfaces (immune synapse formation) Cell segmentation brightfield variance filtered tumor marker T cell marker variance filter normalize & add merge ‘membrane’ + nuclei Cellpose segmentation segmented cells Variance filter Normalize & add Immune markers brightfield Cellpose segmentation High troughput multispectral microscopy of flowing cells Cytek ImageStream BD FACSDiscover S8 brightfield tumor marker (nucleus or membrane) immune cell marker (synapse) marker other markers Experimental setup: Add incubated tumor cells & immune cells, or directly from patient. Capture specific interactions between different cell types. Preprocessing: ImageStream Combiner Issues with exported images: x Many single-channel tiff files per dataset (10000+) x No metadata, channel number in the filename x Not all channels contain data x Every image has a different size x Sometimes a channel is missing ImageStream Combiner merges files into multipage ImageJ tiff Channel names handled in the GUI, or imported with .toml file Process multiple datasets in one run All images same size, background replaced by median of medians https://github.com/BioImaging-NKI/ImageStreamCombiner Nuclear tumor marker Membrane tumor marker Identify immune cell types & quantify cell-cell interactions 1. Segmentation, montage, label processing, di | poster |
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Evelien.LootensStael@UGent.be tel: +32 9 264 68 38 gsm: +32 479 96 24 47 CONTACT 05 Evolution of recovery and desistance paths Challenges faced and solutions proposed by women POLICY INFLUENCE A green paper INFORM JUSTICE AND TREATMENT PROFESSIONALS Informative one-pagers Practice-oriented articles ACCESSIBLE DISSEMINATION Host an inspiration and information day Publish dissertation as a book for wider reach Launch a website providing resources SCIENTIFIC IMPACT SOCIETAL IMPACT 04 DOCTORAL DISSERTATION SCIENTIFIC ARTICLES GOALS RECOVE R Y D E SIST ANCE Further evolution recovery and desistance 12 MONTHS POST-RELEASE Early post-release period critical for relapse risk Discuss evolution recovery and desistance 3-6 MONTHS POST-RELEASE DESISTANCE RECOVERY PERSISTENCE PERSISTENCE ONSET ONSET CRIME DRUG USE DURING INCARCERATION LIFE STORY INTERVIEWS 03 1. How do female RECOVERY pathways evolve? 2. How do female DESISTANCE pathways evolve? 3. What is the RELATIONSHIP BETWEEN RECOVERY AND DESISTANCE in women? 4. What CHALLENGES do women face in their recovery and desistance pathways? 5. What SOLUTIONS do women propose to overcome obstacles in their recovery and desistance pathways? 02 QUESTIONS Greater stigma faced by women using drugs Different criminal trajectories compared to men UNIQUE CHALLENGES Women’s recovery from alcohol and illicit drug use Women’s desistance from crime KNOWLEDGE GAP INTRODUCTION 01 TURNING THE PAGE Women’s Narratives of Overcoming Crime and Addiction EVELIEN LOOTENS-STAEL - PROF. DR. CHARLOTTE COLMAN - PROF. DR. WOUTER VANDERPLASSCHEN | poster |
Problem: Thermal pyrolysis of plastic wastes leads to high M.W. hydrocarbons (Waxes) Scope: In-situ catalytic upgrading of py-oil Target: Naphtha range hydrocarbons Why Naphtha Catalytic upgrading of plastic wastes fast pyrolysis oils towards naphtha range hydrocarbons P. Soldatos1, A. Margellou1, S. Torofias1, A. Lemonidou2, K.Triantafyllidis1,3,* 1 Department of Chemistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece. 2 Department of Chemical Engineering, Aristotle University of Thessaloniki, 54124, Thessaloniki, Greece. 3 Center for Interdisciplinary Research and Innovation (CIRI-AUTH), Balkan Center, 10th km Thessaloniki-Thermi Rd, P.O. Box 8318, 57001 Thessaloniki, Greece *e-mail: ktrianta@chem.auth.gr INTRODUCTION 1 Abbas-Abadi et al., PECS (2023), https://doi.org/10.1016/j.pecs.2022.101046 2 Tan et al., ChemSusChem (2022), https://doi.org/10.1002/cssc.202200522 3 Al-Salem et al., WasMan (2009), https://doi.org/10.1016/j.wasman.2009.06.004 This research has received funding from the European Union’s Horizon Europe research and innovation programme under the HORIZON-CL4-2021-TWIN-TRANSITION-01 grant agreement No 101058412. Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or HADEA. Neither the European Union nor the granting authority can be held responsible for them. References Each year, approx. 400 mil. tons of new plastics are produced, with around 3/4 being common thermoplastics (PE, PP, PET, PS, and PVC). However, less than 20% of Plastic Solid Waste (PSW) is recycled 1,2. Solution? Fast pyrolysis present a promising alternative, effectively handling PSW contamination & heterogeneity, leading to the recovery of valuable chemicals (mainly hydrocarbons) in the form of pyrolysis oil (py-oil) and gases 3 . <20% Recycled ~25% Incinerated ~60% Landfilled Microplastics Leaching GHGs Aim of this work Steam Cracker Petroleum Naphtha Plastics py-oil C2H4 C3H6 Polymerization New Plastics EXPERIMENTAL Characterizations Fast Pyrolysis Results 0 2 4 6 8 10 12 14 16 18 20 3 8 13 18 Yield (wt.%) Carbon Number Beta (12.5) Beta (37.5) ZSM-5 (11.5) ZSM-5 (40) ASA Thermal Naphtha 0 20 40 60 80 100 20 120 220 320 420 520 620 Mass (%) Temperature (oC) LDPE PP HDPE PET PS -50 -40 -30 -20 -10 0 220 320 420 520 620 DTG (%/min) Temperature (oC) *Measurements cond.: 20-700 oC, 10 oC/min, Ν2 Thermal decomposition of polymers TGA/DTG Fixed-Bed Catalytic Fast Pyrolysis (CFP) Reactor LDPE PP PET PS VIRGIN PLASTICS H-ZSM-5 (Si/Al=40, 11.5) H-Beta (Si/Al=12.5, 37.5, 150) H-MOR (Si/Al=10) SiO2-Al2O3 (Si/Al=0.5) CATALYSTS H-FER (Si/Al=10) H-USY (Si/Al=6) Ni/Al2O4, red 10%Ni-W/ZrO2 Catalysts SBET (m2/g) Smicro (m2/g) Vtotal (cm3/g) Vmicro (cm3/g) Brönsted acidity (μmol Py/g) Lewis acidity (μmol Py/g) B/L ZSM-5 (40) 437 332 0.325 0.142 161 21 7.6 ZSM-5 (11.5) 424 349 0.229 0.142 432 104 4.1 BETA (12.5) 596 376 1.263 0.153 177 229 0.8 BETA (37.5) 670 351 1.339 0.145 135 65 2.1 ASA 442 0 0.702 0 38 371 0.1 NiAl2O4, red 97 - 0.147 - - 23 -- Catalysts properties 0 10 20 30 40 50 60 70 80 90 100 LDPE PP PS PET Yield (wt.%) Py-oil Waxes Gases Mass balances of Plastics Thermal Pyrolysis Catalysts screening in LDPE degradation • All acidic aluminosilicate catalysts enhance LDPE decomposition • ASA (Lewis acidity) exhibits similar behavior with strongly acidic zeolites • Among zeolites, ZSM-5 (Si/Al=40) & Beta (150), with fewer but stronger acid sites, show slightly better reactivity ZSM-5 (40) decreased Tmax,DEG ~80 oC Key Parameters Fixed-Bed Fast Pyrolysis (Thermal experiments) LDPE LDPE 450 oC 0 10 20 30 40 50 60 70 80 90 100 ZSM-5 (40) Beta (37.5) Beta (12.5) ZSM-5 (11.5) ASA Thermal Yield (wt.%) Py-oil Waxes Gases 0 20 40 60 80 100 ZSM-5-450 ZSM-5-450 ZSM-5-450 Yield (wt.%) Plastic/Catalyst : 5/1 Thermal pyrolysis of PE/PP predominantly produces high M.W. HCs (Waxes/C16 +) GC-FID LDPE-450 oC Waxes Fixed-Bed Catalytic Fast Pyrolysis Carbon Number Distribution | poster |
Simvastatin sodium salt and fluvastatin interact with the N-terminus of human gap junction gamma-3 protein Acknowledgements We thank EPSRC,Tangent Reprofiling Ltd (SME CASE Award) and the University of Warwick for funding and UHCW NHS Trust for access to facilities and patient tissue. References [1] S. J. Dilly, M. J. Bell, A. J. Clark, A. Marsh, R. M. Napier, M. J. Sergeant, A. J. Thompson, P. C. Taylor, Chem. Commun. 2007, 2808-2810; [2] A. Marsh, K. Casey-Green, S. J. Dilly S. James, W. Dimitri, S. R. Ladwa, P. C. Taylor, D. R. J. Singer PLOS ONE 2016 DOI: 10.1371/journal.pone.0148266; [3] S. Maeda, S. Nakagawa, M. Suga ,E. Yamashita, A. Oshima, Y. Fujiyoshi et al. Nature 458, 2009, 597-602; [4] W.-G. Liang, C.-C. Su, J.-H. Nian, A.-S. Chiang, S.-Y. Li, J.-J. Yang Cell Biochem Biophys 2011, 61, 189-197; [5] M. Billaud A. W. Lohman, S. R. Johnstone, L. A. Biwer S. Mutchler B. E. Isakson Pharmacol. Rev., 2014, 66, 513-569. Andrew Marsh,a* Katherine Casey-Green,a Fay Probert,a David Withall,a Daniel A. Mitchell,b Suzanne J. Dilly,d Sean James,e Wade Dimitri,e Sweta R. Ladwa,d Paul C. Taylor,a Donald R. J. Singerb,c,e** a Department of Chemistry, University of Warwick, Coventry, CV4 7AL b Clinical Sciences Research Institute, Warwick Medical School, Coventry, CV2 2DX c Fellowship of Postgraduate Medicine, 11 Chandos Street, London, W1G 9EB d Tangent Reprofiling Limited c/o SEEK, Central Point, 45 Beech St, London, EC2Y 8AD e University Hospital Coventry and Warwickshire NHS Trust, Coventry, CV2 2DX *@marshgroup a.marsh@warwick.ac.uk **@HealthMed As part of a programme to discover new targets of clinical therapeutics we have applied a chemical genomics approach[1] to the widely prescribed lipid-lowering pro-drug simvastatin. We prepared a genomic T7 phage library from mRNA isolated from sections of internal mammary artery obtained during cardiac bypass graft surgery (NHS National Research Ethics Service, Coventry Research Ethics Committee, Coventry UK: ref - 07/H1210/126).[2] Using immunohistochemistry we found GJC3 to be present in samples of artery similar to those used to prepare the bacteriophage library. Surface plasmon resonance revealed that a 25 amino acid synthetic peptide representing the discovered N-terminus did not interact with simvastatin lactone, but did bind to the hydrolysed HMG CoA inhibitor, simvastatin hydroxyacid. This interaction was also seen for fluvastatin. • Collected from patients in cardiac surgery at UHCW, Coventry • Transported in RNAse inhibitor solution and stored at –80°C • Extracted using Ambion MirVana miRNA isolation kit • 0.023% wt/wt from frozen tissue samples • Extracted using Novagen Straight A's mRNA extraction kit • 1.4% wt/wt from total RNA samples • cDNA prepared using Novagen OrientExpress cDNA kit • Engineered with digestion sites for phage vector ligation • cDNA ligated into T7Select® 10-3 phage vector • Phage amplified in E. coli BLT5615 • Initial library assayed to estimate diversity • Library amplified and a small number of clones sequenced Tissue sample Total RNA mRNA cDNA Phage vector Validation Storage • Library stored at 4°C initially • Long term storage of glycerol solutions stored at –80°C We studied interactions of clones of the bacteriophage, each expressing a different cardiovascular polypeptide, with surface-bound simvastatin that had been immobilised on 96-well plates using a validated photo- immobilisation method.[2] Three rounds of biopanning identified consistent interaction with the clone expressing part of the gene GJC3, which maps to Homo sapiens chromosome 7, and codes for gap junction gamma-3 protein (GJC3), also known as connexin 30.2/31.3 (mouse connexin Cx29).[2] Further analysis indicated the binding site to be the N-terminal domain (see homology model, orange highlight) putatively ‘regulating’ connexin hemichannel and gap junction pores. −30 −20 −10 0 10 0 25 50 75 100 125 150 175 200 225 250 275 residue number Hydropathy /kcalmol−1 protein GJC3 GJB2 pred | poster |
3 1 Understanding the ecological and evolutionary genomics of microbial communities in palm wine fermentation Objective Palm is believed the oldest domesticated plant over the history of human and has been utilized for versatile products. It has been recognised for traditions and cultures in tropical and subtropical countries. However, it is lack of fundamental scientific information for further development. § To understand the fermentation nature, covering the influence of seasonal sap tapping, fermentation time, and palm species through microbial ecology, metabolomic, and genomic perspectives Key findings & future directions We found a swift fermentation process through the depletion of sugar within a few days, indicating a short shelf life of palm wine. Mixed acidic fermentation accompanied by the growth of lactic acid and acetic acid bacteria occurred at the same time as ethanol production, driven by a co-working of Saccharomyces cerevisiae and Zymomonas mobilis. S. cerevisiae was more assertive to the change of micro-ecological factors in the fermentation process. Seasonal sap tapping unchanged the core microbial species and metabolite composition, but they may contribute to specialize product signature. Profile of volatile esters, such as Octanoic acid, and Decanoic acid have set a baseline on determining the fermentation stage characters, capturing every palm species. We are impressed on the dominance of S. cerevisiae and Z. mobilis due to their ability on producing ethanol simultaneously. Further research has been planned to cover some questions on their genome properties affected by local geographic adaptation and their fermentation ability for best practice in the future. Significance By understanding the nature of palm wine fermentation, we can elaborate a better perspective to manage microflora for aroma and flavour, to achieve intended quality and product stability, to establish further product development, and more importantly to appreciate this traditional beverage. I Nyoman Sumerta1,2 and Kate Howell1 1 School of Agriculture, Food Ecosystem Sciences, The University of Melbourne, VIC 3010, Australia 2 National Research and Innovation Agency (BRIN), Jakarta, Indonesia GENERAL OVERVIEW ABSTRACT The important of fermentation nature of palm wine related to current results Take home messages: References: 2 4 5 Grape wine fruits based wine Rice wine grains based wine Palm wine sap based wine Palm wine is made of naturally fermented palm sap, which is significantly influenced by ecological factors and genomic characteristics of its microbial communities. Palm wine is a traditional alcoholic beverage, typically known in Africa, south Asia, southeast Asia, and central America where various palm species grow in their coastal area Ecological factors affected the microbial communities, but not in core structure Metabolite and microbial relationship MAIN RESULTS • Sumerta, IN., Ruan, X. & Howell, K. (2024) The forgotten wine: understanding the fermentation and composition of palm wine. Preprint at Biorxiv. https://doi.org/10.1101/2024.04.26.591403. • Wijaya, L., Sumerta IN., et al. (2024).Cultural, nutritional and microbial perspectives of tuak, a traditional Balinese beverage. J. Ethn. Foods 11, 4 https://doi.org/10.1186/s42779-024-00221-x o The ecological exposure likely had less impact to the core species, while VOCs were likely more affected by ecological factors o Seasonal sap tapping was the main ecological factor, that changed microbial diversity and the amount of VOCs o The role of S. cerevisiae and Z. mobilis needs further study on how they effectively work in palm wine fermentation The relative abundant of bacteria (upper row) was dominated by Zymomonas mobilis, which is known as sucrose fermenting bacteria (ethanol producing bacteria). Acetic acid bacteria (Acetobacter) showed an increase trend over the fermentation period and lactic acid bacteria was responsible for acidic fermentation. On the other hand, Sacchar | poster |
Unraveling Solar analogs from PLATO mission: Rotation and activity recovery from simulated light curves Eduardo Velloso1, Leandro de Almeida4, José Dias do Nascimento Jr1., Francys Anthony, Jefferson da Costa2, Reza Samadi3 Synthetic Sample: In order to assess our ability to recover information from PLATO light curves, we simulated a set of synthetic light curves with both astrophysical modulation and realistic instrumental artifacts. The noise-free light curves were modeled as a linear superposition of starspot rotation and evolution, planetary transits, granulation and oscillations. The simulation of short-timescale effects such as granulations and oscillations are performed via the PLATO Solar-like Light- curve Simulator (PSLS: Samadi et al. 2019). Common instrumental artifacts include data gaps between quarters as well as an exponential thermal settling at the beginning of each quarter. We included data gaps from 1% up to 5% of the 90-day quarter duration, in accordance with the desirable requirements for planet-finding during nominal science operations of PLATO. Methods: To recover the rotational modulation, we applied a series of steps to detrend and stitch the light curve throughout the quarters. Our method identified the discontinuities and separate then from possible transits in between the quarters. Once we have corrected light curves we separated the rotation modulation from the transit signal using the DT method (de Almeida et al. 2020). This method allows us to separate the apparent modulation caused by spots from the transit signal in low cadence light curves. We see that the determination of rotation periods takes place precisely at all levels of activity. From the stars with clear rotation determination (black dots in right figure), we conclude that 92% of the periods found by us are within the 10% confidence interval imposed by the gray region. (1)Departamento de Fisica Teorica e Experimental, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil; (2)Escola de Ciencias e Tecnologia, ECT, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil;(3)LESIA, Observatoire de Paris, Universite PSL, CNRS, Sorbonne Universite, Univ. Paris Diderot, Sorbonne Paris Cite, France; (4)Laboratório Nacional de Astrofísica, Rua Estados Unidos 154, 37504-364, Itajubá - MG, Brazil. References: Samadi, R. et al. 2019 https://doi.org/10.1051/0004-6361/201834822 de Almeida, L. et al. 2020 https://doi.org/10.1007/s10686-020-09664-x | poster |
Positive feedbacks of whole rhizospheric microbial community inoculation on plant performance of three legume shrubs grown on barren quarry deposits. Mantakas G.1, Leventis G.2, Stathopoulou D.2, Petrakis G.3, Tsiknia M.2 Gonou Ζ.4, Ehaliotis C.2 1Hellenic Agricultural Organization “Demeter”, Institute of Mediterranean Forest Ecosystems, Athens, Greece 2Soil Science and Agricultural Chemistry Lab, Dept. of Natural Resources and Agricultural Engineering, Agricultural University of Athens, Athens, Greece 3Rehabilitation Manager, Imerys Industrial Minerals Greece S.A. 4Department of Ecology and Systematics, Faculty of Biology, National and Kapodistrian University of Athens, Greece contact e-mail: ehaliotis@aua.gr Αrid and semi-arid ecosystems of the Mediterranean basin are characterized by low nutrient availability and extended dry and hot periods which drive the community composition and structure of their biota. Dryland legume shrubs, mainly of the Garrigue (Phrygana) ecozone, constitute a critical component of their plant communities. Mutualistic associations between these plants and their rhizospheric microbial communities strengthen their tolerance to abiotic and biotic stresses and enhance water and nutrient use efficiency. It is therefore reasonable to assume, that rhizospheric microbial communities derived from the natural vegetation of conspecifics, would improve plant establishment and performance, and restoration of soil functions, in baren areas covered with quarry deposits in these regions. Here, we investigate the effects of plant inoculation with the whole rhizospheric microbial communities (crude inocula) derived from their naturally occurring conspecifics on early growth and on establishment of symbiosis with rhizobia and arbuscular mycorrhizal fungi (AMF) for three pioneer legume shrubs, in the island of Milos, Medicago arborea, Anthyllis hermanniae and Calicotome villosa. Three pioneer legume shrubs, indigenous to the island of Milos Seeds of each plant species were sown in pots filled either with quarry deposits material derived from quarrying operations at Milos Island – Greece (inorganic substrate) or with a typical propagation substrate, high in organic matter (organic substrate). Inoculation was performed twice, at sowing and two weeks later. Harvest carried out after 160 days. We determined: Total plant biomass Number of nodules per plant AMF root colonization Medicago arborea Anthyllis hermanniae Calicotome villosa Collection of fresh rhizospheric soil from each plant species to create crude inoculum – soil slurry (1:10 soil:H20 w/v) that contains the whole rhizospheric microbial communities Experimental set up | poster |
Results from 138.6 Days of Data Measuring Solar Neutrino Oscillations in the SNO+ Detector Daniel Cookman, on behalf of the SNO+ collaboration The SNO+ Experiment Detection of Solar Neutrinos in Scintillator ●A 780 tonne, multi-purpose liquid scintillator neutrino experiment 2km underground [1] Data & Method 8B solar neutrino survival probabilities, versus true neutrino energy for various solar neutrino oscillation parameters Solar Neutrino Production Matter oscillations in the Sun Vacuum oscillations Matter oscillations in the Earth Detection in SNO+ Combination with Reactor Analysis 8B solar neutrino flux global fit constraint [2]: References [1] Albanese, V. et al, “The SNO+ Experiment”, JINST (2021) [2] Bergström, J. et al, “Status of Direct Determination of Solar Neutrino Fluxes after Borexino”, JHEP (2024) [3] Esteban, I. et al, “The fate of hints: updated global analysis of three-flavor neutrino oscillations”, JHEP (2020); also NuFIT 5.2 (2022), www.nu-fit.org Detection via neutrino-electron elastic scattering: ●138.6 days of livetime (after cuts) of data with LAB + 2.2 g/L PPO scintillator cocktail ●Cuts applied to triggered events: ●Data & MC binned in 2D: reconstructed energy & radius ●MC fit to data using a binned maximum likelihood test statistic, via Markov-Chain Monte Carlo ●Fit floats θ12, Δm2 21, Φ8B, background rates, and energy scale systematic, according to various constraints 20 second muon & high-NHit veto; Data cleaning cuts Reconstructed energy & radius Removal of coincidences via in-window coincidence classifier and out-of-window tag (BiPo-212/214 and (𝛼,n)) External background removal via classifier Data vs MC comparison, using fit parameters with maximal-likelihood. Combined over all radial bins Bayesian 1σ Credible Interval: Current global fit value by NuFit 5.2 [3]: Results statistically-limited; analysis over increased exposure ongoing ●Likelihood from SNO+ reactor analysis added (see posters 483 & 525) to results of this solar analysis: Difference in cross-section between and , and correlation between and scattered energies, allows for measurement of solar neutrino oscillations daniel.cookman@kcl.ac.uk ●Reactor & solar analyses allow for complementary ways of measuring the same oscillation parameters in the same detector! Methods to further reduce backgrounds being investigated: see poster 255 Data vs MC comparison, for innermost radial slice. Zoomed into low energy region. ●Liquid scintillator held within 6m radius acrylic vessel, surrounded by ultra-pure water shielding ●Scintillation light generated by ionising radiation detected by ~9000 PMTs | poster |
Activity-sensitive spectral lines of M dwarfs in the CARMENES visible and near-infrared spectral range: impact on radial velocity determinations and stellar parameters determination Á. López-Gallifa1 (alvlop08@ucm.es), D. Montes1, F. Labarga1, E. Marfil1, H. M. Tabernero2, J. A. Caballero2, M. Lafarga3, S. V. Jeffers4, A. Reiners4, I. Ribas3, A. Quirrenbach5, P. J. Amado6, and CARMENES Consortium1,2,3,4,5,6,7,8,9,10,11 ABSTRACT. In this contribution we summarize our project devoted to identify activity-sensitive spectral lines in the CARMENES visible and near- infrared spectral range of M dwarfs. The aim is to contribute to solve the problem of stellar activity in RV measurements to search for exoplanets around these stars and in the determination of precise stellar parameters. To identify lines with a significant chromospheric contribution, apart from well known activity indicators (Na I D1, D2 He I D3 , Hα, and Ca II IRT lines, He I 10830 Å, Paγ and Paβ lines), we have used the spectral subtraction technique using our Python code iSTARMOD (Labarga & Montes 2020) choosing as reference the spectrum of the star with lower activity. We confirm the new activity-sensitive lines by analysing the correlation with the other well known activity indicators in the same spectra and their temporal evolution in two particular active stars EV Lac (EV Lacertae, M3.5) and YZ CMi (YZ Canis Minoris, M4.5). They are specially active stars with strong flares and strong magnetic fields. In addition, we analyse line by line the template spectrum (co-added of all the individual spectra available) of these two stars applying also the spectral subtraction using in this case as reference star an inactive M dwarf star of similar spectral type to search for magnetically-sensitive lines, that is lines with detectable Zeeman broadening. After this analysis on YZ CMi and EV Lac, we have found 84 and 97 chromospheric activity-sensitive lines and 160 and 170 magnetically-sensitive spectral lines respectively. We are now studying the impact of the elimination of the activity-sensitive spectral lines identified in this way on the RV determination using cross-correlation functions with weighted binary masks as in Lafarga et al. (2020) and on the stellar parameters determination by spectral synthesis as in Marfil et al. (2021). ▲Fig. 1: EV Lac spectrum arround 5498 – 5509 Å at quiescent (left panel) and flare state (right panel). We measure the flux change of the lines in the same range, when there is a flare and when there is not. ▲Fig. 3: Two example of detecting lines affected by Zeeman broadening. The line is noted in our list of sensitive line to magnetic field when the Zeeman broadening can be detected in these plots. ▲Fig. 4: Each of these plots are the output of RACCOON’s code (Lafarga et al. 2020). The code is based on the cross-correlation functions with weighted binary masks and the output shows the radial velocity (RV), full width at half maximum (FWHM), contrast and bisector (BIS). The normal mask and the filtered one on EV Lac in the NIR. Normal mask is used in Lafarga et al. (2020) and filtered is a mask where there are only lines that are not sensitive to stellar activity. It shows how the dispersion of the RV and BIS is lower, showing that eliminating our active lines the plots have less dispersion. Acknowledgements Based on data obtained from the CARMENES project, the German-Spanish priority program at Calar Alto Observatorty. This research is supported by the Universidad Complutense de Madrid (UCM), the Spanish Ministerio de Ciencia e Innovación through projects PID2019-109522GB C51,54/AEI/10.13039/501100011033. 1Universidad Complutense de Madrid ●2Centro de Astrobiología ●3Institut de Ciències de l’Espai ●4Institut für Astrophysik Göttingen ●5Landessternwarte Königstuhl ●6Instituto de Astrofísica de Andalucía ●7Instituto de Astrofísica de Canarias ●8Thüringer Landessternwarte Tautenburg ●9Hamburger Sternwarte ●10Max-Planck-Institut für Astrono | poster |
What’s Causing That Wobble? Building a Model Comparison Framework for TTV Signals Background and Context Transit Timing Variations (TTVs): - There are hundreds of planet with transit timing variation (TTV) signals. - This number will only grow with TESS, CHEOPS, PLATO, Earth 2.0, etc. - There is no robust model selection framework for differentiating the possibly causes of TTV signals. Learning from exoplanet transit modeling: - BLENDER (Torres et al. 2004, 2011) and Vespa (Morton et al. 2016) take a light curve with a transit-like dip and returned a probabilistic framework for predicted the cause of the transit-like dip. de-wobbler ... an open-source package under development: - A model selection approach to disentangling wobbles caused by TTVs. How can TTVs help us differentiate between orbital architectures? Daniel A. Yahalomi1, David Kipping1, David Nesvorny2, Paul A. Dalba3 1: Columbia University, 2: Southwest Research Institute, Boulder, 3: UC Riverside Exoplanets IV, May 1-6, 2022. … daniel.yahalomi@columbia.edu Case Study... KOI-3678b, an exomoon corridor planet multiple planets near MMR super-period: - Steffen 2006 - Lithwick et al. 2016 chopping signal: - Nesvorny et al. 2013 - Deck and Agol 2015 photodynamical modeling: - SWIFT: Nesvorny et al. 2013 - TTVfast: Deck et al. 2014 Next steps for KOI-3678 analysis: - Compare results from SWIFT multi-planet model with follow-up radial velocity (RV) observations. - Include transit duration variation (TDV) modeling in the SWIFT and LUNA photodynamical models. BLENDER and/or Vespa stellar variability eclipsing binary transit time flux epoch TTV de-wobbler Torres et al. 2004 Torres et al. 2011 Morton et al. 2016 moon exomoon corridor: - Kipping 2020 - Teachey 2021 sinusoidal shape: - Kipping 2009 - Rodenbeck et al. 2020 photodynamical modeling: - Kipping 2011 hierarchical system - Agol et al. 2005 - Heller et al. 2019 stellar variability - Mazeh, Holczer, and Shporer 2015 - Holczer et al. 2015 KOI-3678b transit model: - Period = 160.884 days - Rb / R* = 0.079 KOI-3678 stellar parameters: - R* = 0.92 Rsun (TIC v8.2) - M* = 0.95 Msun (TIC v8.2) KOI-3678 LUNA MAP: - Ms / MP = 0.00496 - Rs / RP = 0.129 - as / RP = 67.4 KOI-3678 SWIFT MAP: - Mb / M* = 9.59 x 10-5 - Mc / M* = 1.99 x 10-4 - Pc = 844.56 days Why can’t these TTVs be caused by a hidden planet in near mean motion resonance? exomoon and multi-planet photodynamical fits epoch number TTVs [min] | poster |
Fatty Acids as PET Tracers for Imaging Cardiac Dysfunctions Alessandro Colombano1, Chad Elmore2, Jordi Llop3, Matteo Zanda1 1Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK; 2Early Chemical Development, Pharmaceutical Sciences, IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden, 3Radiochemistry and Nuclear Imaging Group, CIC biomaGUNE, San Sebastián, Spain Email: r01ac16@abdn.ac.uk Heart Failure (HF) is a complex syndrome where the heart is unable to pump enough blood to meet the body’s needs. ATP is the cardiac chemical fuel for this purpose and it is synthesised through the Fatty Acids Oxidation (FAO) pathway: in the healthy heart up to 90% of cardiac energy is synthesised through this pathway!1 A metabolic switch between FAO and glycolysis has been reported during disease progression: in HF early stages the FAO/glycolysis relative rates are unchanged, while in the advances ones there is a FAO downregulation strongly linked with disease progression and severity.2 Hence FAO is a candidate PET biomarker whose assessment would improve early HF diagnosis, patients monitoring and therapy effectiveness. Metabolically trapped probes are particularly interesting because they undergo the FAO generating a radioactive metabolite trapped in the mitochondria reflecting the oxidation rate.3 Background 18F Labelling Tritium labelled tracer synthesis Development and pre-clinical evaluation of modified fatty acids as metabolically trapped FAO PET Tracer Synthesis and in vitro evaluation of tritium labelled tracer Fluorine labelling precursor synthesis 18F radiolabelling Pre clinical imaging Aim Positron emitter Metabolic trapping group expected trapped radioactive metabolite Acyl-CoA- Dehydrogenase Enoyl-CoA- Hydratase Hydroxyacyl-CoA- Dehydrogenase Thiolase Pharmacology and Therapeutics 182 (2018) 95–114 References 1Stanley, W. C, Physiol. Rev. 2005, 85 (3), 1093–1129. 2Dávila-Román, J. Am. Coll. Cardiol. 2002, 40 (2), 271–277. 3Pochapsky, Bioconjugate Chem., Vol. 1, No. 4, 1990; Mather, K. J.; DeGrado, T. R. Biochim. Biophys. Acta BBA - Mol. Cell Biol. Lipids 2016, 1861 (10), 1535–1543. This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska–Curie grant agreement No 675417 Summary A New Fatty Acid Oxidation PET candidate has been designed Developed a multistep synthetic route to prepare the labelling precursors Tritium Labelled tracer has been synthesised In vitro evaluation is in progress Future work β-oxidation inhibition in vitro test Tritiated tracer metabolic profiling in cardiomyocytes [18F] tracer radiosynthesis optimization In vivo preclinical imaging in rodent models of cardiac dysfunctions | poster |
VALIDATION OF LAMP ASSAY FOR Klebsiella aerogenes DETECTION IN THREE VEGETABLE SPECIES Marija Pavlović1, Mila Djisalov2, Ljiljana Šašić Zorić2, Ljiljana Janjušević2, Željko D. Popović1, Ivana Gadjanski2 1Department of Biology and Ecology, Faculty of Sciences, University of Novi Sad, Trg Dositeja Obradovića 3, 21000 Novi Sad, Serbia; 2BioSense Institute, University of Novi Sad, Dr Zorana Đinđića 1, 21000 Novi Sad, Serbia INTRODUCTION Klebsiella aerogenes is a foodborne pathogen that contaminates fruits and vegetables. Detecting it in a timely manner is essential to prevent its transmission through contaminated food sources. In this regard, the LAMP method proved to be a robust, highly sensitive and highly specific method for real-time pathogen detection, and thus method of choice for detection of K. aerogenes. In order to check efficiency of LAMP methodology with fast DNA extraction we conducted LAMP-based K. aerogenes detection in vegetables spiked with bacteria. We selected three distinct vegetable types (carrot, cucumber, and lettuce) that were previosly tested for natural contamination by K. aerogenes. Since the test results came in negative, the tested vegetables were then artificially contaminated (spiked) with a bacterial suspension containing 1.5 x 108 CFU/mL of K. aerogenes in the final sample volume. DNA extraction from the samples was performed using two approaches: Chelex approach for fast extraction to obtain “crude” DNA extract, and Plant/Fungi DNA Isolation Kit (Norgen Biotek Corp., Canada) for spin column extraction to obtain “pure” DNA extract (Fig 1). The total DNA extracted from both methods was subsequently diluted to a final concentration of 1 ng/μL. MATERIALS & METHODS The results indicated successful detection of K. aerogenes by LAMP using total DNA from both extraction approaches. DNA isolated with a commercial kit showed better results compared to the DNA obtained by the Chelex method. For the commercial kit, all three spiked samples were detected: spiked carrot and spiked lettuce around 10 minutes later compared to the positive control, and around 15 minutes later for spiked cucumber (Fig 3a). On the other hand, for the samples obtained with the Chelex method, two of three samples were detected (spiked lettuce and spiked carrot), while the spiked cucumber sample was not detected (Fig 2a). This can be related to the anatomy of the sampled cucumber tissue, which contained the exocarp and mesocarp. K. aerogenes contamination usually occurs on the surface of the cucumber (exocarp) and doesnʹt go further into the tissue (mesocarp). The exocarp contains resin and is therefore harder to homogenize. Regarding the non spiked extracts, the absence of the amplification signal implied that contamination by pathogenic K. aerogenes was not present before the spiking. As for the difference observed in the melting curves between the samples, the low peaks of the curve can be a consequence of the low amount of product obtained in the shorter amplification time for these samples (Fig 2b and 3b). The overall lower efficiency of the Chelex approach can be related to the fact that fast DNA extracts often contain nucleic acid amplification inhibitors. RESULTS ✔The presented research highlights the remarkable potential of the LAMP methodology that can be efficiently combined with fast DNA extraction methods for in-field detection of pathogens. ✔Improvements for the Chelex method could be made in light of sample selection, different sampling approaches, homogenization methods (specifically the intensity and duration of homogenization) and removal of potential reaction inhibitors from the obtained “crude” extracts. ✔The commercial kit showed better compatibility with LAMP for sample preparation and the Chelex method has shown great potential for point-of-need use. CONCLUSION Acknowledgments: This research was funded by MSCA-RISE H2020 project IPANEMA (grant agreement number 872662) and by the Ministry of Science, Technological | poster |
Suitable data formats for seismological big data provisioning via web services @EoscPillar EOSC-Pillar has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No. 857650. Introduction Seismological web services have been designed some years ago with particular types of user and data in mind, which are not exclusively what we see today. Disruptive techniques, generating data at much a finer resolution, compared to the standard seismic stations, are a challenge for data centres and users. Despite seismology is an advanced and well organized discipline considering FAIR principles, these new datasets would make impossible to still use the same standard data formats and standard specifications for data provisioning services. Our main aim in this Task is to keep FAIRness in this community through evaluating new data formats suitable for this use case, testing and implementing tailor made services where possible within the currently defined standards. We develop a package tool named dastools as a set of tools to read, manipulate and convert seismic waveforms generated by DAS systems. Challenges addressed The web service providing seismological data (Dataselect) is an international standard adopted by most of the seismological data centres. Data formats to be evaluated are also known internationally. Some of the challenges we addressed through EOSC-Pillar are the following: Services involved extend the service to be suitable to providing big amounts of data, as these are expected to be received synchronously. provide the needed metadata to properly interpret the data when interacting with other web services packaging these data and metadata using container technology FDSN Dataselect FDSN Station-WS Publication/Images/videos Partners Quinteros, J. (2021): dastools - Tools to work with data generated by DAS systems. V. 0.5. GFZ Data Services. https://doi.org/10.5880/GFZ.2.4.2021.001 Quinteros, J., Carter, J. A., Schaeffer, J., Trabant, C., & Pedersen, H. A. (2021). Exploring Approaches for Large Data in Seismology: User and Data Repository Perspectives. Seismological Research Letters, 92(3), 1531-1540. doi: https://doi.org10.1785/0220200390. Call for abstract submission to the Session in the European Seismological Conference (ESC) in September 2021 https://www.erasmus.gr/UsersFiles/microsite1193/Documents/SESSIONS_ABS TRACTS3.pdf Benefits through EOSC-Pillar Thanks to EOSC-Pillar, as well as developments in previous EOSC projects, users of dastools will benefit from integration with other common services and infrastructure offered by EOSC-Pillar. For instance, the Authentication and Authorization Infrastructure (AAI) integrated in EIDA/ORFEUS and provided by the B2ACCESS service hosted by Forschungszentrum Jülich. Another benefit due to the collaboration with Pillar partners will be the capability to process on the data centre side using the downsampled replica of these data. Fig. 1: A fiber-optic cable in the seafloor; after Jousset, P., 2019, Science Here is what we have achieved: • MS27 Code for standard Dataselect-WS from new non-standard big datasets in seismology -achieved. • Capability to convert to standard formats from two different proprietary formats used by the most important manufacturers of this type of equipment (TDMS from Silixa, and OptoDAS from Alcatel). • Ready-to-use data provisioning web services. Light weight and providing data in standard formats (e.g. miniSEED) and through standard protocols (FDSN-Dataselect). Anyone can use this to expose the raw data in a full standard way. • After one year of a joint effort with partners from two of the most important seismological data centers at international level (IRIS-USA, RESIF-France), we were able to provide a complete landscape analysis covering all aspects of the data life cycle for these novel datasets. The results were published in a high Impact Factor Journal of our community (SRL). • We include in our analysis a | poster |
Recent results from the DANSS experiment XXXI International Conference on Neutrino Physics and Astrophysics Nataliya Skrobova (nataliya.skrobobva@gmail.com) for the DANSS collaboration DANSS design JINST 11 (2016) no.11, P11011 ●DANSS – Detector of reactor AntiNeutrino based on Solid-state Scintillator ●Location: Kalinin Nuclear Power Plant (KNPP), 3.1 GW commercial reactor, 5∙1013 ν cm-2 s-1, 50 m w.e. overburden ●10.9 -12.9 m from the reactor core center, movement online ●Multilayer Cu + CHB + Pb + CHB passive shielding ●Two-layer muon veto on 5 sides ●2500 scintillator strips with Gd containing coating for neutron capture ●Light collection with 3 WLS fibers ●Central fiber read out with individual SiPM ●Side fibers from 50 strips make a bunch of 100 on a PMT cathode = Module ●Dedicated WFD-based DAQ system 2 of 50 modules Conclusions ●We fit the observed positron spectra using the sum of 4 isotopes (HM model) ● 238U and 241Pu fission fractions are fixed (corresponding to KNPP data), ● 235U fission fraction is free parameter ●Each measurement corresponds to ∼ 6-10 days of data taking (~1% stat. accuracy) Measurements of σ5/σ9 (σ8/σ9 and σ1/σ9 are taken from Huber Phys.Rev.C,84,024617 and Mueller Phys.Rev.C,83,054615) DANSS result σ5/σ9 = 1.54 ± 0.06 is larger than Day Bay Phys.Rev.Lett.120,022503 (1.445 ± 0.097) and agrees with Huber + Mueller (1.53 ± 0.05). Use of DB-Slope in our formula gives: σ5/σ9 = 1.459 ± 0.052 ⇒ difference between DANSS and Daya Bay is due to slope Searches for sterile neutrinos High energy neutrinos Measurements of absolute νe flux Experimental uncertainty without νe flux – 4% Observed to predicted ratio: 0.98±0.04 (HM model), 1.02±0.04 (KI model) DANSS results are consistent with both models within errors Total uncertainty in IBD rates (including νe flux) – 7% Systematic uncertainties (1σ): ●Energy scale (2%) and shift (50 keV) ●Energy resolution (additional smearing 6%/√E ⊕ 2%) ●Correlated backgrounds (35%) ●Distance to the fuel burning profile center (5 cm) ●Relative efficiencies (0.4%) Using current statistics we see no statistically significant evidence of 4ν signal (best point significance: ~2.0σ ) Exclusions are calculated using Gaussian CLs method ●DANSS analysis without absolute counting rates excludes a large and the most interesting fraction of sterile neutrino parameter space using only ratio of e+ spectra at 3 distances. ●Oscillation analysis with absolute counting rates (HM model) excludes practically all sterile parameter space preferred by BESTPhys.Rev.Lett.128,232501 and the best fit point of Neutrino-4 Phys. Rev. D 104, 032003 experiment. A conservative uncertainty of 7% was assumed for absolute counting rates. ●In KI model exclusion is even more strict. ●Exclusions based on absolute IBD rates for large ∆m2 support previous results (Daya Bay, Bugey-3, ...) Fission fraction reconstruction 7 years of running ●3 detector positions, pure positron kinetic energy (annihilation photons not included) ●> 8 mln IBD events, ~ 5000 events per day in the closest position ●Signal/Background > 50 ●Reactor power is measured by the DANSS with neutrino flux with 1.3% accuracy in 3 days during more than 7 years! Top position Middle position Bottom position ●Correction for dead time, efficiency, neighbor reactors power (individually) ●Mean normalization for the whole campaign is used ●Reactor #4 power and fission points distribution profile are not taken into account ●Fit range: 1-3 and 5.5-7 MeV (excluding so-called “bump”) ●Difference in 235U fraction between KNPP and DANSS is ~3% ●The estimated ratio of σ5 /σ9 = 1.54 ± 0.06 is consistent with the HM model and it is slightly larger than the KI and Daya Bay results ●Obtained accuracy in 235U fission fraction reconstruction is ~3% ●Observed to predicted ratio with absolute νe counting rates is 0.98±0.04 for HM model, and is 1.02±0.04 for KI model ●DANSS excludes a large and the most interesting fraction of sterile neutrino parameter space using only rat | poster |
Growth of antimonide IR detectors in MOCVD technology Krzysztof Kłos 1,*, @Photin_MOCVD kk@photin.eu Karel Melichar2 Jiri Pangrac2 Alice Hospodkova2 Paweł Michałowski3 1 Photin LLC, Poland www.photin.eu, 2 Institute of Physics CAS, v.v.i., Czech Republic www.fzu.cz 3 Łukasiewicz-IMiF Poland, Introduction Semiconductors from so called 6.1A group GaSb-InAs-AlSb are having unique features such as high mobility, type 2 bandgap lineup, which makes them attractive materials for high- end applications in solar cells, thermophotovoltaic cells, IR emitters, IR detectors, TFET transistors or new types of RAM memory(UltraRAM). This work share information about growth of GaSb, lattice matched InGaAsSb and AlGaAsSb on (100) GaSb substrates in Aix-200 horizontal MOCVD reactors: 1) assisted by Reflectance Anisotropy Spectroscopy (RAS) in-situ monitoring.[1], [2]. 2) standard Aix-200 RF without in-situ monitoring The target layer structure to be developed is eSWIR barrier detector structure aimed at unbiased operation at 300K. This kind of structures were intensively analyzed, developed and optimized[3], due to yield of ~50% with so called “extended InGaAs/InP”(fig. 2a VIGO@IC-MOVPEXX2022). InGaAsSb/AlGaAsSb structures were grown in MOCVD by Wang[4] and Dutta et al.[5], and in MBE [3], [6], [7]. GaSb AlGaSb AsGaSb InGaSb AlGaAsSb InGaAsSb p 2e18 cm-3 N-GaSb (Te) substr. GaSb buffer InGaAsSb base InGaAsSb absorber AlGaAsSb barrier GaSb 0.5µm 0.3µm 2.0µm 0.3µm 0.1µm Thickness Doping n 1e18 cm-3 n 2e18 cm-3 n 2e17 cm-3 undoped undoped Layers Figure 1: a) development matrix of GaSb-based ternary and quaternary compounds, b) layer structure of eSWIR detector The best results reported in literature so far were processed in Lancaster University by Laura Hanks[3] in ams-OSRAM project, as could be seen on fig. 2b. Figure 2: a) development matrix of GaSb-based ternary and quaternary compounds, b) layer structure of eSWIR detector Experimental - Material Growth The GaSb based structures were grown in an AIXTRON Aix-200 system horizontal quartz reactors for 1x 2” wafer with RF heaters, details of the growths with RAS monitoring were reported earlier[8]. The most of runs were dedicated to optimization of buffer GaSb growth. Results Figure 3: Comparison of buffers grown by Photin - Nomarsky contrast. Figure 4: a) In-situ RAS and Reflectance. b) HR XRD profile of full structure grown. The In-Situ monitoring is not so sensitive for mismatch (fig. 4a). HR XRD profile shows mismatch ~3200ppm, which cause elevated dark current of processed devices. Figure 5: Comparison of pictures with Nomarsky on FZU(left) and Photin(right) GaSb buffers. Figure 6: a) High resolution SIMS profile of barrier region and their neighbourhood. b) T2SLs GaSb/InAs trial monitored by In Situ RAS The SIMS measurement reveal proper, Al composition profile, correct Zn profile, extremely stable and steep Te doping profile transitions (fig. 6a) in critical region of devices. Figure 7: Two processing schemes were tested: planar (top), and mesa (bottom). Conclusions 1. Technological conditions were explored for the growth and doping of complex IR detector structure consisting GaSb, InGaAsSb and AlGaAsSb layers. 2. Processing and full characterization of grown eSWIR epi-structures 3. Developed technology is being optimized by Photin. References [1] A. Hospodková et al., “Growth of InAs/GaAs quantum dots covered by GaAsSb in multiple structures studied by reflectance anisotropy spectroscopy,” Journal of Crystal Growth, vol. 414, pp. 156–160, Mar. 2015, doi: 10.1016/j.jcrysgro.2014.10.026. [Online]. Available: https://linkinghub.elsevier.com/retrieve/pii/S0022024814007118. [Accessed: 06-Jun-2022] [2] K. Möller et al., “In-situ monitoring and analysis of GaSb(100) substrate deoxidation,” Applied Surface Science, vol. 242, no. 3–4, pp. 392–398, Apr. 2005, doi: 10.1016/j.apsusc.2004.09.006. [Online]. Available: https://linkinghub.elsevier.com/retrieve/pii/S0169433204013376. [Accessed: 06-Jun-20 | poster |
SISTEMA PARA AVALIAÇÃO DA FUNÇÃO AUTONÔMICA UTILIZANDO A VARIABILIDADE DA FREQUÊNCIA CARDÍACA Thiago G. Terra, Marcus V. B. Franco, Lucas B. Lopes, Mariana Ucker, Jefferson L. B. Marques Instituto de Engenharia Biomédica, Universidade Federal de Santa Catarina, Florianópolis, Brasil 1. INTRODUÇÃO A variabilidade da frequência cardíaca (VFC) é uma técnica considerada importante para avaliação do sistema nervoso autônomo (SNA) pois descreve as oscilações dos intervalos entre batimentos cardíacos consecutivos [1, 2]. Portanto, o presente estudo tem como objetivo desenvolver um sistema baseado em técnicas de processamento de sinais para gerenciamento de pacientes e aquisição do sinal de eletrocardiograma (ECG) no intuito de utilizar tal indicador para o estudo da relação deste com a atividade do SNA. 2. MATERIAS E MÉTODOS O sistema desenvolvido é composto por um concentrador (software) e o módulo de aquisição que, atuando em conjunto, são capazes de coletar dados via serial e armazenar e analisar os dados coletados. O software desenvolvido é composto por uma interface que possibilita ao usuário realizar o cadastro e gerenciamento de pacientes, coleta dos dados dos módulos de aquisição, armazenamento e análise dos dados coletados (Figura 1). Figura 1. Diagrama de funcionamento do sistema desenvolvido. Figura 3. Software desenvolvido: análises no (a) domínio do tempo, (b) frequência e (c) não-linear. 4. DISCUSSÃO E CONCLUSÃO O sistema proposto pode ser aplicado para auxiliar na detecção precoce da neuropatia autonômica diabética e como ferramenta para realizar o screening da população uma vez que o sistema permite o cadastro e gerenciamento de pessoas e dados coletados e a análise da VFC [1]. 3. RESULTADOS Figura 2. Software desenvolvido: (a) acesso, (b) gerenciamento de pacientes, (c) aquisição de sinais e (d) resultados do exame. REFERÊNCIAS [1] A. da Silva, M. Barbosa, F. Vanderlei, D. Christofaro, L. Vanderlei, “Application of heart rate variability in diagnosis and prognosis of individuals with diabetes mellitus: systematic review,” Ann. Noninvasive Electrocardiol, vol. 21, n. 3, pp. 223–235, 2016. [2] L. Vanderlei, C. Pastre, R. Hoshi, T. Carvalho, M. Godoy, “Noções básicas de variabilidade da frequência cardíaca e sua aplicabilidade clínica,” Rev. Bras. Cir. Cardiovasc., v. 24, n. 2, pp. 205–217, jun. 2009. | poster |
MENDIOLA D1., Paredes L2., Akaboci T2., Llenas L2., Ponsa S2. 1Caviar Pirinea S.L.U., Yesa (Navarra), Spain. 2 BETA Technological Centre, Univ. of Vic-Central University of Catalonia, Spain. diego.mendiola@caviarpirinea.com lidia.paredes@uvic.cat INTRODUCTION The H2020 SEA2LAND project (2021-2024) aims to provide solutions to help overcome challenges related to food production, climate change and waste reuse. This project will meet this challenge by improving and adapting technologies for nutrient recovery to produce bio-based fertilisers (BBFs) and Tailor Made fertilisers (TMFs) from fishery and aquaculture by-products generated in Europe. Therefore, SEA2LAND will contribute to independence and secure the supply of nutrients to European agricultural systems and will promote the production of large-scale fertilizers (from non-imported raw materials), based on the circular economy model to transform by-products into nutrients for crops. Particularly, CAVIAR PIRINEA together with some research partners are mading available extended catalogue of animal by product, which are routinely sold to waste managing companies with no valorisation income derived. The technological approaches developed herein by BETA Technological Centre (BETA TC) are revealing that within a private aquaculture production scenario of 3.100Tn fish/year (i.e., rainbow trout (O. mykiss) and sturgeon (Arcipenser sp.)) and 1.902Tn of fresh processed products/year (i.e., fish, roe and caviar) => 69m3 fish sludge, 96Tn fish víscera and 200Tn of non-conforming fish/year could respectively be valuated through some of the current research techniques in progress. Likewise, the project could show that every increased productivity as derived from intensification in aquaculture and/or fish processing practices will not only lead to a subsequent huge, but also economically recoverable production of agro innovative byproducts. The solutions developed are expected to reduce the soil nutrient imbalance in Europe. MATERIAL & METHODS RESULTS AND DISCUSSION Acknowledgements: SEA2LAND project is a collaborative Innovation Action(IA) funded by the EU in the frame of the Horizon 2020 programme. The project is running from January 2021 to December 2024. Website: www.sea2landproject.eu Understanding the value of freshwater aquaculture and fish processing by-products through agroinnovative approach & technological solutions An innovative technological approach is being evaluated within some of the work packages for the valorization of aquaculture by-products (fish sludge and dead fishes). The SLUDGE is separated into solid and liquid fractions. Solid fraction valorization is conducted by applying biodrying processes, aiming to reduce the water content and obtain a nutrient-rich biodried product to be used as an organic amendment. The combustion of this product to recover phosphorus from the ashes to produce phosphoric acid is also expected. The feasibility of recovering the volatilized ammonia during the biodrying to produce ammonium salt is also under current evaluation within the project. The liquid fraction from sludge is being valorized by using several concentration processes. The method consists of an ultrafiltration (UF) system to separate solid particles present in the liquid fraction. The permeate produced by UF passes through the reverse osmosis (RO) system to concentrate the nutrients. The RO concentrate generated is subsequently processed in a Freeze Concentration (FC) unit, where the water is crystallized, and the nutrients are recovered in a nutrient-rich concentrate product. Moreover, a high-quality RO permeate with potential to be reused in the aquaculture industry facilities is also produced. Likewise, dead trout FISH FROM FARMING MORTALITY is used as co-substrate of the solid fraction in the bio-drying process. Figure 2: Technologies applied for the liquid fraction valorization. C. Fish Sludge from the processing plant. D. Dead fish as co-substrate. E. Mechanical pro | poster |
Open profiling of chemical knowledge What is Wikidata? • the edit button of the semantic web • collaboratively curated Linked Open Data • one of the largest public knowledge graphs (over 11 billion triples about over 90 million entries) • growing quickly, yet far from complete • supported by contributions from 20k users a month • available under CC0, i.e. in the public domain • multilingual and cross-disciplinary • FAIR: Findable, Accessible, Interoperable, Reusable • part of the Wikimedia ecosystem • integrated with thousands of other databases • used by major search engines & many other tools How is chemistry covered? There are over a million entries for which Wikidata knows an InChiKey. This is one of the 8k proper- ties available for describing Wikidata entities. About 100 of these are mainly for chemistry, and there is a demo of a Wikidata-powered periodic table. Data modeling and curation for chemistry-related content is overseen by WikiProject Chemistry. How does Scholia work? Scholia is a Flask-based webservice that renders the results of templated SPARQL queries to the Wiki- data Query Service, which provides dynamic access to Wikidata content. The concept to be profiled – given via its Wikidata ID or some other identifier – is a parameter to the query, and the kind of profile can be user-defined. The Scholia source code is available on GitHub, under the GPL3 license. Daniel Mietchen (@EvoMRI) ORCID: 0000-0001-9488-1870 School of Data Science, University of Virginia Try Scholia for exploring chemistry-related Linked Open Data that is collaboratively curated through Wikidata: https://scholia.toolforge.org This poster is a contribution to the Beilstein Open Science Symposium 2020 and available under CC BY-SA 4.0 via https://doi.org/10.5281/zenodo.4095649. Scholia is supported by •the WikiCite community & WikiProject Scholia •the Alfred P. Sloan Foundation under grant number G-2019-11458. Chemical compound Prize Journal Chemical class Researcher Biological pathway Protein Research topic Powered by Credits: BetterPoster LATEXTemplate by Rafael Bailo under GPL3, based on Mike Morrison’s BetterPoster. | poster |
教員養成系⼤学⽣を対象とした STEM教育に関する授業実践の試み Practical Study on STEM Education for School Teacher Training Course Students 丸山雅貴（早稲田大学）・長濱澄（東京工業大学）・北澤武（東京学芸大学） 瀬戸崎典夫（長崎大学）・森田裕介（早稲田大学） 教員として， STEM教育を どう指導するか？ 科目 東京都内の教員養成系大学 「ITを活用した授業づくり」 期間 2019年6月～7月 対象 学部生11名（2年以上） 問題の所在 研究の方法 結果 3.11 1.33 2.00 1.78 4.11 2.22 2.44 2.56 1 2 3 4 5 事前調査 事後調査 ** * * ** 事前・事後調査 **：p < .01, *：p < .05 項目 STEM関連のコースを 履修するのは楽しい STEMに関連した 授業の指導案を作成できる STEM関連を児童・生徒に 教える教員になる自信がある STEMの担当教員として 一人前にやっていける自信がない （逆転項目） 9. 12. 14. 15. 学習指導要領改訂 「探究的な学び」の重視 教科・科目の独立性 教科横断型の難しさ 謝辞 本研究の⼀部は，JSPS科研費JP17H02003の助成を受けたものである． 授業の概要 課題レポート ワークシート 各自で設計図を作成 ダンボールカーの製作 振り返り 事前調査 イメージの記述 事後調査 イメージの記述 毎回繰り返す )-# $0 *!/' 1*!( "., &% !+ &% 9GL? AO -3 0 KM @K#:J" CB $6 'CB P5$6 ++E)N ( @K#:J" CB ! $6 'CB !P5$6 + +E)N ( STEM教育の実践に関する動画を 視聴させ，4問の問いに取り組ませた後， STEM教育に対する イメージを図示・記述 課題レポート 考察 STEM教育に関する調査 Value-Expectancy STEM Assessment Scale （Appianing・Van Eck，2018） 教員養成系⼤学⽣向けに改良 22項⽬▶15項⽬ 「ロイロノート・スクール」 を用い，探究のプロセスを記録 「STEM教育」の観点から， 後半ミッションにおける 学習活動を振り返ってください （800字程度） LMSを⽤いて提出 平均値 グループで競争意識を 楽しませることが 探究のプロセスの体験に 有用となる可能性 21世紀型教育などと 結びつけての検討により， 学校教員になった際に 活用する志向 ❶ ❷ N = 9 特徴的な 単語の抽出 学生の記述例（抜粋） グループ 個人ではなくグループで行うことで， 一人では思いつかなかった 新しい可能性に気づいた ロイロノート 「ロイロノート」を活用しながら 試行錯誤を繰り返しながら 改善していった 教壇 自分が教壇に立つ際には， 今回学習した内容を活かした 授業をしていけたらと思う 競争 競争する要素も含んでいることで， 生徒達の学習意欲も高まることが 予想される | poster |
Non-binary turbo codes (NB-TC): new design and low-complexity decoding KLAIMI Rami ABDEL NOUR Charbel DOUILLARD Catherine FARAH Joumana NB-CC structure Conclusion New design of NB-TCs is proposed with excellent high and low SNR performance Reasonable complexity-increase thanks to the proposed simplified decoder Better performance than existing binary and non-binary codes Introduction Turbo codes over GF(q), q>2 Design steps: • Define NB-CCs • Study the interleaving and puncturing techniques • Design a low-complexiy decoder RSC over GF(q) RSC over GF(q) RSC over GF(q) RSC over GF(q) π Motivations: • Capacity gains of CM vs BICM • Resistance to burst errors • Lower correlation in decoding • Good perf/complexity tradeoff 2 3 4 5 6 7 8 9 10 1 0 Eb/N0(dB) 100 10-1 10-2 10-3 10-4 10-5 10-6 10-7 BER Binary code 64-QAM GF(64) 64-QAM Binary code BPSK GF(64) BPSK Binary 64-states convolutional code Non-binary CCs over GF(64) Performance comparison with binary CCs of similar complexity Interleaving and puncturing Maximize spread and correlation girth values Maximize the number of non-punctured systematic and parity symbols within a cycle Puncture less reliable bits in constellation symbols Low-complexity decoder Simplified algorithm based on a modified bubble sorter Avoids computing unreliable trellis states NB-TCs perform beyond BICM capacity Performance comparisons NB-TC vs NB-LDPC code [1] and 5G polar code for short and moderate frame sizes NB-TC vs binary and non-binary [2] LDPC codes mapped to 64-QAM constellations 2 1.5 1 0.5 0 -0.5 -1 -1.5 Es/N0(dB) 100 10-1 10-2 10-3 10-4 10-5 BLER NB-TC over GF(64) 5G-Polar code-CA_SCL (L=32) NB-LDPC over GF(64) 5G-Polar code-CA_SCL (L=8) Kb=60 bits; Nb=180 bits QPSK constellation 6.5 6.75 7 7.25 7.5 7.75 8 8.25 8.5 8.75 Es/N0(dB) 100 10-1 10-2 10-3 10-4 10-5 10-6 10-7 BLER NB-TC over GF(64) 5G-Polar code-CA_SCL (L=32) 5G-Polar code-CA_SCL (L=8) NB-TC over GF(64) Kb=972 bits; Nb=1080 bits QPSK constellation 13 13.2 13.4 13.6 13.8 14 14.2 14.4 Es/N0(dB) 100 10-1 10-2 10-3 10-4 BLER NB-LDPC over GF(64) NB-TC over GF(64) Kb=1536 bits, R=2/3 64-QAM constellation 6 6.25 6.5 6.75 7 7.25 7.5 7.75 8 8.25 8.5 Es/N0(dB) 100 10-1 10-2 10-3 10-4 10-5 10-6 10-7 10-8 BLER NB-TC over GF(64) LDPC DVB-T2 NB-TC over GF(64) Ks=900, 64-QAM Symbols Kb=5400 bits,R=1/3 Effect of the decoder simplification 5.75 6 6.25 6.5 6.75 7 7.25 7.5 Es/N0(dB) 10-3 10-2 10-1 100 10-4 BLER Min-Log Conf1-R10-nm16 Conf2-R4-nm8 Conf3-R2-nm4 Conf3-R2-nm4-6It Binary16States Binary64States NB-TC over GF(64) Ks=900, 64-QAM Symbols Kb=5400 bits,R=1/3 10 -3 10 -2 10 -1 10 0 10 -4 BLER 20 40 60 80 100 120 140 160 180 ACS*10 6/Frame Min-Log Conf1-R10-nm16 Conf2-R4-nm8 Conf3-R2-nm4 Conf3-R2-nm4-6It Binary16States Binary64States Authors Contact: rami.klaimi@imt-atlantique.fr 25% gain in minimum distance [1] http://www-labsticc.univ-ubs.fr/nb_ldpc/ [2] Gutierrez, I., Bacci, G., Bas, J., Bourdoux, A., Gierszal, H., Mourad, A., & Pleftschinger, S. “Davinci non- binary LDPC codes: Performance and complexity assessment.” IEEE Future Network & Mobile Summit. Florence, Italy, June, 2010, pp. 1-8. Grant agreement No. 760150 | poster |
Silicon Burning Neutrinos at Super-K with Gadolinium Charles Simpson, for the Super-Kamiokande Collaboration References [1] GADZOOKS! Anti-neutrino spectroscopy with large water Cherenkov detectors, J.F. Beacom and M.R. Vagins, PRL 93 (2004) [2] Odrzywolek et al. doi.org/10.1063/1.2818538 [3] Odrzywolek th.if.uj.edu.pl/~odrzywolek/ [4] A. Barna and S. Dye, “Web Application for Modeling Global Antineutrinos,” arXiv:1510.05633 1. Super-Kamiokande • 50 ktons water, 22.5 kton fiducial volume • Instrumented with 11129 20 inch PMTs • Detects Cherenkov light from charged particles passing though water • Already hugely successful in proton decay searches and neutrino detection • Soon to be upgraded for next phase with Gadolinium doping • By adding 0.2% Gd salt by mass, will detect up to 80% of neutrons [1]. 2. Thermal Neutron Capture on Gadolinium • Isotopes of Gadolinium have some of the highest cross sections for thermal neutron capture[1]. • Neutron capture followed by gamma ray cascade of around 8 MeV within 20 microseconds; enough energy to be reliably detected in Super-K. • Neutron capture gammas are studied using MC • Background is modelled using real data taken in SK e+ p n g Gd ne g g often invisible thermalisation 3. Pre-Supernova Silicon Burning Neutrinos • Extra early supernova warning for nearby stars – before the usual supernova neutrino signal • Never before seen astrophysical object, not visible to EM astronomy! • Massive star prior to core collapse • Star running out of H and He • Contracts and gets hotter • Heavier nuclei are fused • Rapid increase to production of neutrinos and antineutrinos [2] • At SK-Gd, detection efficiency for antineutrinos will be increased by neutron detection Time to SN in hours 250 − 200 − 150 − 100 − 50 − 0 Events per hour 2 − 10 1 − 10 1 10 2 10 Odrzywolek 15M Odrzywolek 25M Signal event rate at 0.2kpc Rapid increase in event rate at SK before supernova Data from [2] and [3] 6. Summary and Conclusion • The next stage of Super- Kamiokande is doping with gadolinium for efficient neutron tagging • A supernova is often preceded by silicon burning • Silicon burning rapidly increases the electron antineutrino luminosity and average energy – can be detected by SK-Gd • Main backgrounds are intrinsic radioactivity and reactor neutrinos • SK-Gd would detect this for a star up to 900 parsecs away • Up to 60 hours early warning before Betelgeuse goes supernova Supernova Neutrinos Silicon Burning Neutrinos Mean Energy ~20 MeV Mean Energy ~2 MeV Hours before light from SN Days before light from SN Detected in 1987 Never detected before 1000s of events in seconds at SK at >10kpc 100s of events in a day at SK-Gd for stars at <1kpc 5. How much warning and range? • Depends on mass of star, and the mass hierarchy! • Some uncertainty in intrinsic background and Japanese nuclear reactor situation • Max warning for Betelgeuse is ~60 hours (1 per 2 year type-II error rate assumed) • Max range for 3σ discovery ~900 parsecs • There are 41 red super giants in this range • Low energy backgrounds at SK are intrinsic radioactivity and cosmic muon spallation products • Look for neutron capture candidates in coincidence with very low energy positron candidates • Main background may be reactor neutrinos – will depend on Japanese nuclear reactors • Alarm would watch for an increase in the rate of candidate events • Compare the last day with the last 30 days and do a hypothesis test on Poisson distribution • Likelihood threshold set by type-II error rate: is 1 false alarm per month OK? 1 per year? 1 per 10 years? Reactor data from [4] Positron candidate total energy (MeV) 0 1 2 3 4 5 6 7 8 Events per 24 hours per 0.20 MeV 1 - 10 1 10 Final 24 hours at 150 parsec Accidental BG BG ν Reactor and Geo Silicon burning signal, 15M 150pc 25M 4. Backgrounds Distance (kparsec) 0.1 0.2 0.3 0.4 0.5 0.6 0.7 0.8 0.9 1 Warning time (hours) -1 10 1 10 2 10 Normal Hierarchy solar 15 M Normal Hierarchy solar 25 M Inverted Hierarchy solar 1 | poster |
Resultados Miquel Sierra, Joan Muñoz, Cristina Madrid López Problema / objetivo La energía eólica es esencial para la transición energética y su tecnología cambia rápidamente. El PNIEC23 propone un 31% de energía eólica en el mix de energía eléctrica primaria para 2030, y el PROENCAT un 51% para 2050. La investigación sobre los impactos ambientales de la energía eólica, se basa normalmente en el análisis de ciclo de vida (ACV). Sin embargo, los inventarios que se utilizan para este análisis están obsoletos. En el proyecto JUSTWIND4ALL hemos: Creado el modelo WindTrace para parametrizar inventarios de turbinas, ayudando a que el ACV se ajuste mejor a la realidad de l sector. 1. Analizado a modo de ejemplo el impacto ambiental de turbinas y parques en base a estos parámetros. 2. METODOLOGÍA Hemos modelizado las siguientes fases: extracción de materias primas, manufactura, transporte, instalación, mantenimiento y fin de vida. Usamos datos de la literatura científica y de informes de la industria. WindTrace usa el software de ACV de código abierto Brightway2.5 y la base de datos Ecoinvent para la construcción y manipulación de los inventarios. Calculamos impactos con el método ReCiPe 2016. conclusiones y trabajo futuro Conclusiones: WindTrace permite dimensionar los inventarios de ciclo de vida de las turbinas eólicas y ajustar los flujos de las diferentes etapas a sus características técnicas y localización en el terreno. Los materiales son la fase con mayor impacto sobre el calentamiento global en los tres ejemplos analizados (75-85%). La instalación es la etapa que más contribuye a los impactos sobre el uso del suelo. Trabajo futuro: Desarrollo del modelo para turbinas eólicas marinas, incluyendo plataformas eólicas flotantes. Evaluación de los impactos ambientales de la flota eólica actual en Europa, incluyendo más indicadores Análisis de las barreras que suponen estos impactos para la transición energética. CUANDO no hay datos: el modelo windtrace para parameterizar inventarios de eólica Mostramos el ejemplo del calentamiento global y el uso del suelo de un parque eólico real en la Figura 2. Calentamiento global: La etapa de materiales es responsable de más del 85% del impacto. El acero es el material con mayor contribución (36%) seguido del acero cromado, la fibra de vidrio y la electrónica (10-15%). Uso del suelo: La etapa de instalación representa el 74% del impacto. La ocupación directa de suelo de la turbina y las vías de acceso al parque se contabilizan en esta etapa. La fase de materiales contribuye un 21% al impacto por la ocupación de las minas en la extracción. Este trabajo está financiado por la Generalitat de Catalunya con el contrato 2021 SGR 00734; el Ministerio de Ciencia e Innovación, con una ayuda de la Agencia Estatal de Investigación con contrato PID2020-119565RJ-I00 y CEX2019-0940-M; y la Unión Europea, con una ayuda del programa Horizon Europe con contrato 101083936. CONTACTO — miquel.sierra@uab.cat — cristina.madrid@uab.cat Figura 2. Contribución de las diferentes etapas del ciclo de vida a los indicadores de impacto de calentamiento global y uso del suelo en un parque eólico real situado en Alemania, con especia l émfasis en los materiales. Los indicadores se han tomado del método ReCiPe 2016 midpoint (H). Figura 1. Lista de parámetros de turbina y de parque que el modelo necesita para generar los inventarios parametrizados. | poster |
Implementação de um teste de aleatoriedade para avaliar um algoritmo de criptografia baseado em caos Bruno Piazera Larsen; Jeaneth Machicao Universidade de São Paulo larsen.bruno.p@gmail.com; machicao@usp.br Objetivos O objetivo principal deste projeto de iniciação científica é a implementação de um algoritmo de criptografia baseada em caos. Para isto, a avaliação da pseudo-aleatoriedade do algoritmo também é de grande interesse, e está sendo realizada em paralelo. Assim, o objetivo do presente trabalho é a implementação de um teste de aleatoriedade que seja sensível o suficiente para medir as propriedades pseudo- aleatórias do caos. Métodos e Procedimentos Neste trabalho foi proposto e implementado um novo teste de aleatoriedade baseado na proposta de Zhu [1], expandindo-o para testar todas as sequências possíveis, até um tamanho m. De acordo com esse trabalho, dado um vetor aleatório de n-bits é esperado que, buscando um padrão de tamanho m usando uma janela fixa, a distância entre os padrões siga uma distribuição exponencial de parâmetro 2-m. Será usado o teste de Kolmogorov-Smirnov para determinar o p-valor da amostra, e depois o teste será reaplicado nos p-valores obtidos, que devem seguir uma distribuição uniforme. Se o p-valor for muito baixo, a hipótese nula pode ser descartada. Uma vez que esse teste estiver pronto, será implementado o sistema criptográfico, e o teste de aleatoriedade será usado para validar a qualidade do sistema, junto de outros testes usados na literatura (DIEHARDER e NIST). Resultados Preliminares A qualidade do teste proposto foi avaliada usando o gerador pseudo-aleatório baseado no k-mapa logístico [2] e uma amostra não aleatória. Os padrões de intermitência podem ser observados na Figura 1. Usando padrões diferentes (diferentemente do que foi proposto por Zhu) alguns padrões ficam muito aparentes. Figura 1: Frequências de intermitência em uma amostra não aleatória (topo) e em uma aleatória (fundo) saindo do padrão 111 e buscado 000. Conclusões Preliminares Pelos resultados preliminares podemos concluir, com um otimismo cauteloso, que o teste será muito mais sensível que os testes atuais, dado que o programa possa ser refinado. Referências Bibliográficas [1] Zhu, S. (2015). A Randomness Test Based on the Distribution of Position for Pre-Specified Pattern. In 2015 International Conference on Computer Science and Mechanical Automation (CSMA). IEEE. [2] Machicao, J., & Bruno, O. M. (2017). Improving the pseudo-randomness properties of chaotic maps using deep-zoom. Chaos: An Interdisciplinary Journal of Nonlinear Science, 27(5), 53116. | poster |
Parallel Roads to the Traveling Salesman 3/2-Approximation Metric Traveling Salesman Problem (TSP) Find: A shortest tour visiting each vertex of an edge-weighted graph at least once. NP-hard: No polynomial-time algorithm is known. In 1976, a polynomial-time algorithm for computing a tour of length no more than 3/2 of the optimum was discovered simultaneously in the English and Russian literature. Actually, it is the end of a series of three parallel discoveries. 1973/74: The Chinese Postman Problem (CPP) Find: A shortest tour visiting all edges of an edge-weighted graph. Solvable by computing a maximum-weight matching in an auxiliary graph. 1973: Christofides finds the connection between CPP and matching, solves the re- sulting matching problem in polynomial time using Edmonds’ 1965 algorithm. 1974: Serdyukov finds the connection be- tween CPP and matching, solves the result- ing matching problem in exponential time, being unaware of Edmonds’ algorithm. 1975: Faster Matching Algorithms Lawler: O(n3)-time implementation of Edmonds’ matching algorithm. Karzanov: O(n3 log n)-time implementa- tion of Edmonds’ matching algorithm. Likely, Serdyukov learned about the polynomial-time solvability of the maximum- weight matching problem from a preliminary version of Karzanov’s article. Both results are published only in 1976. 1976: 3/2-Approximation Algorithm for TSP Algorithm: First compute a minimum-weight spanning tree and then a shortest tour traversing it, via matching, like for CPP. February: Christofides describes the al- gorithm in a technical report at Carnegie Mellon University. January: Serdyukov submits it to the journal Upravlyayemye Sistemy of the In- stitute of Mathematics in Novosibirsk. Full article: R. van Bevern and V. A. Slugina: A historical note on the 3/2-approximation algorithm for the traveling salesman problem. Historia Mathematica, 2020. doi:10.1016/j.hm.2020.04.003, arXiv:2004.02437 | poster |
oPoly(lactic acid) (PLA) synthesized via reactive extrusion ring-opening polymerization of L-lactide using a catalyst. oTwo different bacterial celluloses, BNC and BMFC used at 0.5 wt% relative to L-lactide mass. oCharacterization through XRD, DSC and TGA. The project has received funding from the European Union’s Horizon 2020 Research and Innovation Programme under Grant Agreement No. 952941 biomac@chem.auth.gr INTRODUCTION EXPLORING THE EFFECT OF CELLULOSE ON THE STRUCTURAL AND THERMAL PROPERTIES OF POLY(LACTIC ACID) (PLA) – BASED FILMS AUTH Eleftheria Xanthopoulou*, Georgia Lathira*, Rafael Sanchez**, Pilar Albaladejo Sánchez**, Giacomo Marra***, Miguel Angel Valera***, Charilaos Xiros****, Z. Terzopoulou*, D. Bikiaris* * Laboratory of Polymer and Colors Chemistry and Technology, Department of Chemistry, Aristotle University of Thessaloniki, 54124, Thessaloniki, Greece ** Instituto Tecnológico del Embalaje, Transporte y Logística, ITENE, Unidad Asociada al CSIC, C/Albert Einstein 1, 46980, Paterna, Valencia, Spain *** AIMPLAS, Asociación de Investigación de Materiales Plásticos Y Conexas, Carrer de Gustave Eiffel, 4, 46980 Paterna, Valencia, Spain **** RISE Processum AB, SE-891 22, Örnsköldsvik, Sweden EXPERIMENTAL RESULTS AND DISCUSSION CONCLUSIONS oThe incorporation of BNC and BMFC affected the thermal transitions of PLA-based films. oBoth DSC and XRD analyses suggested crystallization of all materials after the annealing procedure. oThe thermal stability was sustained and depended on the cellulose type and molecular weight of the final nanocomposite. This study investigates the effect of bacterial nanocellulose (BNC) and microfibrillated cellulose (BMFC) reinforcement on the performance of poly(lactic acid) (PLA) based films synthesized by reactive extrusion (REX), a rapid and cost-effective method for polymer functionalization, blending, and compatibilization. L-lactide Catalyst 15 min BNC or BMFC fraction 0.5 wt% XRD patterns of (a) quenched and (b) annealed (at 80 °C for 1h) PLA-based films. TGA curves of (a) the % mass and (b) the first derivative of mass loss in PLA-based films. o PLA has a Tg=59.9 °C, Tcc=112.1 °C and a melting point at Tm=166.4. °C. o Tg, Tcc and Tm have a decreasing trend, following the Mn trend. o All materials had the diffraction peaks of PLA. o Small diffraction peaks of the additive appeared in PLA-BNC pattern. o All materials exhibit two distinct degradation steps, the first corresponding to the loss of moisture content and the breaking of cellulose components and the second to PLA. o The Tonset of the PLA segments is not significantly affected by the presence of the additive. 5 10 15 20 25 30 35 40 45 Intensity (counts) 2theta (degrees) PLA REX BMFC PLA REX BNC PLA REX (a) 5 10 15 20 25 30 35 40 45 Intensity (counts) 2theta (degrees) PLA REX BMFC PLA REX BNC PLA REX (b) 100 200 300 400 500 0 20 40 60 80 100 Mass (%) Temperature (°C) PLA REX PLA REX BNC PLA REX BMFC (a) 100 200 300 400 500 -35 -30 -25 -20 -15 -10 -5 0 DTG (%/min) Temperature (°C) PLA REX PLA REX BNC PLA REX BMFC (b) SEM image of PLA BMFC composite. 40 60 80 100 120 140 160 180 200 Normalized Heat Flow (W/g) Endo Up Temperature (°C) PLA REX BMFC PLA REX BNC PLA REX 0.5 W/g (b) 40 60 80 100 120 140 160 180 200 Normalized Heat Flow (W/g) Endo Up Temperature (°C) PLA REX BMFC PLA REX BNC PLA REX 0.5 W/g (a) Sample Tg (°C) Tm (°C) Tcc(°C) Tc(°C) Xc (%) PLA REX 59.9 166.4 112.1 100.4 25.1 PLA REX BNC 57.1 165.8 104 94.2 33.4 PLA REX BMFC 51.2 164.9 96.5 91.4 37.8 DSC heating scans of (a) quenched and (b) annealed (at 80 °C for 1h) PLA-based films. | poster |
In our analysis we took into account the full observational information: energy, time, and angle for all events. For each detector we included: background, dead time, biases, and an accurate treatment of efficiencies. Our study favors the existence of the accretion phase with a significance of 𝚫𝝌𝟐= 𝟖. 𝟗, in accordance with literature. We performed a systematic investigation of the likelihood profile for all parameters, which allowed us to understand the characteristics of the likelihood function and to estimate uncertainties and correlations independently of the Hessian approach; see figure as an example. Finally, to test the validity of our model, we performed a hypothesis test adopting the Cramer criterion for each cumulative distribution represented in the figures above, obtaining satisfactory results reported in the table on the right. The combined probability maximization of all experiments produces parameter estimates whose values are consistent with the expectations of the theory. The agreement with the temporal and energy distributions of the model is excellent; that with the angular distributions is suboptimal but still acceptable. We conclude that our model effectively describes the anti-neutrino burst of SN1987A, highlighting salient features of interest for astrophysics and future observations. The results will be published and detailed in a paper in the near future. Supernova 1987A (SN1987A) is a Type II event that occurred in the Large Magellanic Cloud, approximately 168,000 light-years from Earth. An associated neutrino emission was observed: three experiments, Kamiokande-II, IMB and Baksan, detected a total of 29 events in a time span of about 30 seconds. This provided general support for theoretical expectations, which predict neutrinos as the main source of energy release in a core-collapse supernova event. SN1987A continues to be a key object of study, as it is the only such phenomenon observed to date. We present a state-of-the-art analysis of the SN1987A data, which corrects certain inaccuracies of previous analyses and is based on a new modelling of the neutrino flux, more consistent with the expectations of astrophysical simulations. Riccardo Maria Bozza1,2, Vigilante Di Risi1, Giuseppe Matteucci1,2, Veronica Oliviero1,2, Giulia Ricciardi1,2, Francesco Vissani3,R 1 Department of Physics ‘E. Pancini’, University of Naples Federico II, Naples, Italy 2 Istituto Nazionale di Fisica Nucleare Napoli, Naples, Italy 3 Laboratori Nazionali del Gran Sasso (INFN), Assergi, Italy 4 Osservatorio Astronomico di Brera (INAF), Merate, Italy Riccardo Maria Bozza1,2, Vigilante Di Risi1, Giuseppe Matteucci1,2, Veronica Oliviero1,2, Giulia Ricciardi1,2, Francesco Vissani3,4 1 Department of Physics ‘E. Pancini’, University of Naples Federico II, Naples, Italy 2 Istituto Nazionale di Fisica Nucleare Napoli, Naples, Italy 3 Laboratori Nazionali del Gran Sasso (INFN), Assergi, Italy 4 Osservatorio Astronomico di Brera (INAF), Merate, Italy Image Credit: NASA, ESA, CSA, M. Matsuura (Cardiff University), R. Arendt (NASA’s Goddard Spaceflight Center & University of Maryland, Baltimore County), C. Fransson (Stockholm University), J. Larsson (KTH Royal Institute of Technology), A. Pagan (STScI) A recent model (Symmetry 2021, 13(10), 1851) parametrizes the temporal profile of the incoming anti-neutrino flux from a CCSN in two independent components: accretion and cooling, accounting for an initial ramp-up phase for both components, as predicted by supernovae models. According to the mentioned model, accretion and cooling can be described by a single function: We calculated the differential interaction rate for Kamiokande-II, Baksan and IMB and employed a global Bayesian approach to estimate the best fit parameters for the model. Our approach at analyzing the neutrino emission The results for Kamiokande-II Best Fit Parameters Best fit parameters are obtained by maximizing the likelihood function with reasonable constraints provided by | poster |
Yuwei Hu1,2, Helen Beggs3 and Xiao Hua Wang1,2 1.Sino-Australian Research Centre for Coastal Management, University of New South Wales, Canberra, Australia 2.School of Science, University of New South Wales, Canberra, Australia 3.Bureau of Meteorology, Melbourne, Australia Inter-Comparison Groups Sea surface temperature (SST) climatology datasets provide the reference for observations of ocean anomalous events such as coastal upwelling and Marine Heat Waves (MHWs), which may have significant effects on the local marine ecosystem. The representativeness of the SST climatology datasets of the historical and current ocean surface states is essential to identify and predict anomalous events. Here we compare four high resolution SST climatology datasets around the Australian coast to investigate uncertainty introduced by reference SSTs to estimates of SST anomalies. The datasets studied are: (i) 0.05-degree SST Climate Change Initiative (CCI) global daily climatology for 1981-2016, 1985-2012, 1992- 2016 and 1994-2016, calculated by this study from the ESA SST CCI Analysis product version 2.0 (Rayner et al., 2019), a satellite-only SSTdepth analysis created by the UK Met Office OSTIA SST analysis system from SST CCI Along Track Scanning Radiometer (ATSR) and SST CCI Advanced Very High Resolution Radiometer (AVHRR) products (1981-2016); (ii) 0.02-degree SST Atlas of the Australian Regional Seas (SSTAARS), a pixel-wise daily climatology for 1992-2016 (Wijffels et al., 2018), based on the 0.02-degree bias-corrected version 2 Integrated Marine Observing System (IMOS) one-day composite night-time AVHRR SST; (iii) 0.05-degree NOAA Coral Reef Watch (CRW) global monthly climatology for 1985–2012 (https://coralreefwatch.noaa.gov/satellite/coraltemp.php), derived from the MyOcean OSTIA Reanalysis (1985-2002) and NOAA Geo-Polar Blended SST reanalysis (2002–2012), and (iv) 0.1-degree BRAN SST daily climatology for 1994-2016, derived from the BRAN_2016 ocean reanalysis data generated by the Ocean Forecasting Australian Model version 3 (OFAM3) ocean model (Oke et al.,2013). Three climatology comparison groups based on these four SST products are formed (Table 1) and statistical analysis of the differences in each climatology comparison group are conducted followed by the in-situ validation using TAO/TRITON mooring SST1m climatology (https://www.pmel.noaa.gov/gtmba/taotriton- collaboration). In this study we define CCI as the a reference to compare with CRW, SSTAARS and BRAN climatology datasets, with all comparisons performed over the SSTAARS domain (Figure 4). Groups CCI_1985 – CRW, CCI_1992 – SSTAARS and CCI_1994 – BRAN are compared to reduce potential impact of the reference period on SST differences in each CCI related group. The comparison groups from (a) to (c) are listed in Table 2 together with the five main factors affecting the comparison, including whether day and night data were included, reference period, data central year, climatology calculation algorithm and whether or not the climatology represents the same SST depth. Table 1. Main attributes of the climatology datasets Acknowledgements Y. Hu a candidate in UNSW Canberra, has been financially supported by the China Scholarship Council and the top-up scholarship from UNSW Canberra since August 2017 for her PhD studies in Australia. The authors would like to thank the European Space Agency CCI Project for providing the SST CCI analysis v2.0 data, and BoM internal reviewers Chris Griffin, Frank Colberg and Grant Smith for giving very helpful comments and suggestions to this study. This work is supported by the Sino-Australian Research Centre for Coastal Management. Statistical Analysis Differences of each comparison group are calculated along with temporal relative bias (Figure 1) and standard deviation (STD, Figure 2) in each valid SSTAARS grid cell. Density distributions of differences within time bins are then calculated. The SST differences are first classified in time bins base | poster |
Juan J. Payares1,2, María J. Álvarez2, José R. Hernández1, Aldo F. Combariza2 1Civil Engineering Department (School of Engineering), 2Biology and Chemistry Department (School of Education and Science) 1Research Group of investigation environmental and wate-Gimaguas University of Sucre 2Research Group of Evolutionary Biology, 2Molecular Modelling and Computational Simulation, University of Sucre Problematics present Tests for evaluation of mechanical properties Corn cell walls structure and fiber scheme. Influence of fibers in concrete Cob Corn SOURCE http://old.tell.cl/magazine/6084/rancagua/agosto/2012/entr evistas/viva-el-choclo.html Source:http://www.mun.ca/biology/desmid/brian/BIOL2060/BIOL2060-01-06/CB01-06.html References 1.. Chávez Porras, Álvaro, & Rodríguez González, A. 2016. Aprovechamiento de residuos orgánicos agrícolas y forestales en Iberoamérica. Academia Y Virtualidad, 9(2), 90-107. https://doi.org/10.18359/ravi.2004 2. Sánchez Bernal, R., Pita Castañeda, J., González Velandia, K., & Hormaza Verdugo, J. (2018). Análisis de mezclas de residuos sólidos orgánicos empleadas en la fabricación de ladrillos ecológicos no estructurales. Revista De Ciencias Ambientales, 53(1), 23-44. https://doi.org/10.15359/rca.53-1.2 3. Lv, Lihua; Bi, Jihong; Ye, Fang; Qian, Yongfang; Zhao, Yuping. 2017. Extraction of discarded corn husk fibers and its flame retarded composites. pp 408-413. 4. Vajje, S. ; Krishna, M. 2014. Study On Addition Of The Natural Fibers Into Concrete Saandeepani.pp https://doi.org/10.1061/(ASCE)ST.1943-541X.0001251 5. acques, Eric; Lloyd, Alan; Imbeau, Paul; Palermo, Dan; Quek, Jeslin. 2015. Concrete Columns Subjected to Simulated Blast Loading https://doi.org/10.1061/(ASCE)ST.1943-541X.0001251- 6. Torkaman, J., Ashori, A., & Sadr Momtazi, A. (2014). Using wood fiber waste, rice husk ash, and limestone powder waste as cement replacement materials for lightweight concrete blocks. Construction and Building Materials, 50, 432–436. https://doi.org/10.1016/j.conbuildmat.2013.09.044 7. Martín, Ana Balea. 2019. Celulosa nanofibrilada y su aplicación en la industria papelera para la mejora de productos reciclados. 8. Amigó, Vicente; Salvador, Mª Dolores; Sahuquillo, Oscar. 2008. Aprovechamiento de residuos de fibras naturales como elementos de refuerzo de materiales poliméricos Nishiyama, Y., Langan, P., & Chanzy, H. (2002). Crystal Structure and Hydrogen-Bonding System in Cellulose Iβ from Synchrotron X-ray and Neutron Fiber Diffraction. Journal of the American Chemical Society, 124(31), 9074–9082. doi:10.1021/ja0257319 Bledzki, A. (1999). Composites reinforced with cellulose based fibres. Progress in Polymer Science, 24(2), 221–274. doi:10.1016/s0079-6700(98)00018-5 The skeletal model represents the cellulose chains Model for the description of the stiffness of the fibre Source:https://www.semanticscholar.org/paper/Shear-Behavior-Models-of-S teel-Fiber-Reinforced-Hwang-Lee/0ea29080112e4e9be135d760af60cec034 9a0a0e/figure/4 Source:https://www.ibertest.es/products/maquina- de-ensayo-para-materiales-de-alta-resistencia-la- compresion-serie-meh/ Source: Sucre University laboratory Source:: http://www.capsf.org.ar/generales/344-novedades-en-la-liquid acion-de-las-estructuras Source:https://www.lasprovincias.es/c omunitat/ayuntamiento-valencia-culp a-20171124203929-nt.html Source:https://www.prensalibre.com/ guatemala/comunitario/lluvias-arrastr an-mas-desechos/ GIMAGUAS Mechanical behavior of fibers extracted from cob corn as reinforcement in concrete beams.| Acknowledgement. For the support received and the constant reminder that everything we want can develop, as long as we work with passion and commitment, so i wish dedicated to thank my teachers and family that make me improve every day. my professors Aldo F. Combariza and José R. Hernández. | poster |
Use of Stable Isotope Ratio Analysis (SIRA) for the identification of invasive species native in alien environments Funding Non-competitive funding mechanism. Each funder only pays for the participation of their own national researchers. Total funding € 60 000 Picture 1 Picture 1 Picture 1 Goals To develop Stable Isotope Ratios Analysis (SIRA) as arthropod tree pest determination tool, to be used to obtain reliable information about the origin of exotic pest species. The ability to make this determination could form part of the decision-making process on the actions and measures to be taken, in case of interceptions or outbreaks of non-native species. Research consortium Defra (GB), BLT (AT), CREA (IT), APHIS (US), Uorleans (FR) Contact information Project coordinator: Katharina Heinrich Katharina.Heinrich@fera.co.uk Key outputs and results • A preliminary exploration of isotopic signatures for the identification and differentiation of geographic origin of various species. The extent of the exploration will depend on the availability of samples within the project group and this is likely to vary between species. The ability to differentiate between specimens of different geographical origins is also likely to vary between species depending on their climatic range, host trees and landscape utilisation. • An assessment as to whether the data from one pest can be utilised for another pest with a similar feeding regime. This will depend on the identical host tree species, the specific parts of the tree consumed by the insects and their life cycles. • Guidelines and recommendations for decision- making based on the data produced. Objectives Sourcing of tree pest specimens, e.g. Anoplophora glabripennis (ALB), Monochamus, etc. from different geographic regions in sufficient numbers for SIRA and statistical evaluation of the results. A sub-topic will be the combined analysis of insect specimen and host tree wood/bark for the investigation of correlation between their stable isotope patterns. 10/2018-03/2021 | poster |
Rachel J. Harding1, Peter Loppnau1, Suzanne Ackloo1, Alexander Lemak2, Ashley Hutchinson1, Brittany Hunt1, Alex S. Holehouse3, Jolene C. Ho1, Lixin Fan4, Leticia Toledo-Sherman5, Alma Seitova1, Cheryl H. Arrowsmith1,2 1 Structural Genomics Consortium, University of Toronto, MaRS South Tower, 101 College Street, Toronto, Ontario M5G 1L7, Canada, 2 Princess Margaret Cancer Centre and Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 1L7, Canada, 3 Department of Biomedical Engineering and Center for Biological Systems Engineering, Washington University in Saint Louis, Saint Louis, Missouri 63130, USA, 4 Basic Science Program, SAXS Core facility of National Cancer Institute, Frederick National Laboratory for Cancer Research , Frederick, MD 21701, USA, 5 CHDI Foundation, 6080 Center Drive, Suite 700, Los Angeles, CA 90045, USA From proteins to people: an open toolkit to accelerate Huntington’s disease research Huntington’s disease research has been hampered by a paucity of openly available biochemical tools to facilitate research into this devastating disease and help develop new therapeutics. This project aimed to generate resources for the Huntington’s disease research community, available without restriction, with the hope of accelerating research of the huntingtin protein which functions aberrantly in patients with this disease. Summary General population 15, 19, 23, 24, 25, 30 15, 19, 23, 24, 25, 30 HD patients 36, 42, 48 Juvenile HD patients 51, 52, 54, 60, 66, 73, 78, 79, 85 Extreme expansions 109, 139, 142, 145 pBacMam2-DiEx-LIC Huntingtin constructs are unencumbered and were created for open distribution ~15,000 publications referencing Huntington’s disease <50 publications detailing experiments with purified full-length huntingtin protein samples Data from PubMed search March 2019 for “Huntington’s disease” & “purified huntingtin protein” The mechanism of Huntington’s disease remains incompletely understood Many therapies in development and most of the current clinical trials targetting Huntington’s disease, aim to lower the levels of the huntingtin protein to slow or stop disease progression. Aim: Design and characterise an open toolkit of Huntington’s disease research resources for biochemical investigation of huntingtin protein Huntington’s disease patients have an expansion mutation in a CAG-repeat region of the huntingtin gene. This mutation leads to neuronal cell dysfunction and progressive neurodegenerative decline with complex psychological, cognitive and physcial symptoms. There are no disease modifying therapies available for Huntington’s disease. General population huntingtin gene < 35 CAG repeats Functional huntingtin protein Healthy neuron Patient population huntingtin gene > 35 CAG repeats Aberrant huntingtin protein Neurodegeneration However, we still don’t know very much about the physiological function of this criticial protein molecule. An open-source toolkit to make huntingtin protein samples Huntingtin is in the top 1% of human genes, encoding a 3000+ amino acid protein. This creates many technical barriers to make huntingtin protein samples. Constructs with different expansions were generated to allow expression and purification of huntingtin proteins reflecting different populations: pBacMam constructs permit flexible expression in either insect or mammalian cells to suit the needs of different labs. Suspension eukaryotic culture systems allow scalable production of protein, facilitating purification of large quanitites of material, needed for subsequent biochemical analysis. 5 10 15 0 50 100 150 200 Elution Volume (mL) A280 mAU Gel Filtration of insect HTT1-3144 Q23 HTT1-3144 Q23 250 130 100 75 55 48 35 25 15 MW (kDa) 11.5 12 12.5 13 13.5 14 Elution Volume (mL) 10 4-20% SDS-PAGE of monomer peak fractions Huntingtin samples can be simply purified with a 2-step protocol using FLAG-affinity chromatography and gel filtration. This yields highly pure huntingtin samples. Protei | poster |
Earth Observation and Climate Processes (EOCP) – Evaluating the Feasibility of Sentinel-2 Data for Drought Stress Detection in Urban Trees Max Gerhards1*, Henning Buddenbaum1, Jessica Friedrichs1, Christian Lindner2 and Frank Knospe2 1 Earth Observation and Climate Processes, Trier University, 54286 Germany 2 Stadt Essen, Amt für Geoinformation, Vermessung und Kataster, Lindenallee 10, 45127 Essen, Germany ‚TreeCop‘: a Pilot Project Urban areas are highly vulnerable to heatwaves, which have direct negative effects on human health and well-being. Urban green and in particular urban trees provide crucial ecosystem services (i.e., shade and cooling, etc.). These services mitigate the negative effects associated with climate change, and thus contribute to the quality of life in our cities and comply with several sustainable development goals (e.g., SDG 3 – good health and well-being, SDG 6 – clean water, SDG 11 – sustainable cities and communities). However, urban trees are also exposed to climate change- related increases in drought stress and tree dieback as a result of heatwaves, leading to a reduction in their ability to provide ecosystem services. Therefore, early detection of drought-stressed trees, in the context of a healthy urban climate and increased climate resilience of cities, is particularly important to ensure the preservation and function of urban greenery through targeted irrigation of stressed trees while conserving drinking water resources. ‘TreeCop’, as a pilot project, evaluates the potential Sentinel-2 imagery for drought monitoring in the city of Essen. Over 40 (rising) in-situ sensors (Fig. 3, left) measuring soil moisture provide a unique validation basis. Examinations on the interactions between Sentinel-2 imagery and in-situ sensors forms a solid base for the development of an optimized small- scale irrigation management system (Fig. 2). First results are very promising: Sentinel-2 data were processed with FORCE on CODE-DE (Fig. 1), areas of potential drought stress could be revealed (Fig. 3, right) and a dashboard containing all in-situ meas. was implemented (Fig. 4). However, various difficulties have been identified that need to be addressed. For example, only mild stress symptoms were observed remotely, since urban trees are well adapted to their habitat and no drought stress occurred in 2021. Luckily ‘TreeCop’ was extended until end of 2022 to study another vegetation period with more and new sensors at non-disturbed locations (i.e., forests) to better understand the correlations between Sentinel-2 imagery and in-situ sensors. References Frantz, D. 2019. Remote Sensing 11 (9): 1124. https://doi.org/10.3390/rs11091124. Funding: Deutsches Zentrum für Luft- und Raumfahrt (DLR), Raumfahrtmanagement mit Mitteln des Bundesministeriums für Verkehr und digitale Infrastruktur (BMVI), FKZ: 50EW2010 A & 50EW2010 B Contact: gerhardsm@uni-trier.de, https://www.uni-trier.de/?id=74823 Figure 4: Dashboard containing all in-situ soil moisture measurements and showing their temporal course. 2020-09-19 2020-09-19 Figure 3: ARD Sentinel-2 image Essen with locations of in-situ sensors (left), MSI-difference image (right) – the darker the larger the difference to a non-stressed reference date. Brownish areas indicate potential drought stress. Blue areas are not threatened. Non-vegetated areas are displayed in RGB. in-situ sensors CODE-DE: Analysis Ready Data We utilized FORCE (Framework for Operational Radiometric Correction for Environmental monitoring: Frantz 2019) - an in-house software package designed for mass-processing satellite image archives such as the Sentinel- 2 data stream from the European Copernicus Program as it is available in CODE-DE. A data cube of analysis-ready data (ARD) was created (Fig. 1), holding atmospherically and topographically corrected surface reflectance datasets as nadir BRDF-adjusted bottom-of-atmosphere reflectance (BOA). The reflectance data are accompanied by per-pixel quality inform | poster |
Background The Lower–Balonne floodplain system was identified as a priority in the Northern Basin Review process and it was recognised that region-specific knowledge on floodplain vegetation was limited. Consequently a commitment was made to un- dertake research aimed at improving the understanding of the water availability and use by four key floodplain vegetation species (three trees; Coolabah, River red gum and Black box, and a shrub; Lignum) which are common in the Lower–Balonne. This research was done as part of the Australian Government’s Murray-Darling Ba- sin Environmental Water Knowledge and Research (EWKR) project and was con- ducted by Queensland’s Department of Natural Resources, Mines and Energy (formerly DNRM) and Department of Environment and Science (formerly DSITI). Contact Bill Senior Department of Environment and Science Queensland Government E: bill.senior@des.qld.gov.au Dr Nikki Thurgate Project Coordinator Centre for Freshwater Ecosystems La Trobe University P: + 61 2 60 249690 E: n.thurgate@latrobe.edu.au W: latrobe.edu.au/freshwater- ecosystems Improving the understanding of water availability and use by vegetation of the Lower-Balonne Floodplain The Lower-Balonne floodplain The Lower-Balonne floodplain is a distributary river network within the Condamine- Balonne catchment located between the town of St George in southern Queensland and the Barwon River in northern New South Wales. It is comprised of a complex series of braided channels, floodplains and waterholes. Floodplain vegetation is a key ecosystem component of the Lower-Balonne and relies on permanent and peri- odic flooding, to a greater or lesser extent, depending upon its type and position in the landscape. Centre for Freshwater Ecosystems Fact Sheet | poster |
Figure 3 : We present here the log g – Teff diagram for our sample. White dwarfs with He+C, homogeneous He+H and stratified He+H atmospheric compositions are shown in blue, red and green, respectively. The black lines represent hydrogen@deficient evolutionary sequences from Althaus et al. (2009), labeled by stellar mass (in solar masses). We note that almost all carbon@polluted objects have Teff > 60,000 K, which indicates that gravitational settling removes carbon from the atmosphere with cooling. Also, the scatter in log g values increases at Teff > 70,000 K, probably because of the lower sensitivity of He II lines to surface gravity at high temperatures. Furthermore, white dwarfs with stratified atmospheres are all found in the range 50,000 K > Teff > 40,000 K, which corresponds to the hot end of the so@called DB gap (a range in effective temperature, 45,000 K > Teff > 30,000 K, where a significant deficit of helium@rich white dwarfs is observed). Thus, these objects are probably undergoing the DO to DA transition, as residual hydrogen (previously mixed in the envelope) gradually diffuses upward. Finally, one prominent feature of this diagram is the tendency for low log g values at Teff < 50,000 K, which we discuss in the next figure caption. A)Non-LTE)Model)Atmosphere)Analysis)of)Hot,)Hydrogen-Deficient)White)Dwarfs Antoine)Bédard*,)Pierre)Bergeron,)Gilles)Fontaine Université de)Montréal,)*bedard@astro.umontreal.ca White dwarf stars of spectral type DO populate the hot end of the hydrogen-deficient white dwarf cooling sequence. They are characterized by a helium-rich atmosphere, a high effective temperature (Teff > 40,000 K) and a high surface gravity (log g > 7), and thus their spectrum is dominated by broad He II absorption features. Their hydrogen deficiency is thought to result from a so-called born-again evolution, during which a post-AGB star undergoes a late helium-shell flash, bringing the star back to the AGB and causing the remaining hydrogen to be burned or completely mixed in the envelope. In order to further our understanding of hydrogen-deficient white dwarf evolution, we perform a model atmosphere analysis of a large sample of DO stars. Atmospheric parameters are derived by comparing optical spectra to our new grid of non-LTE model atmospheres and synthetic spectra. We also make use of evolutionary sequences to obtain stellar masses and cooling ages. Based on these results, we discuss the physical properties of DO white dwarfs. Figure 1 : This figure shows the best fits to the optical spectra of some DO white dwarfs in our sample (each offset by 0.5), together with the corresponding Teff and log g values. The observed and theoretical spectra are displayed as black and red lines, respectively. Our sample is composed of 103 DO stars observed spectroscopically in the Sloan Digital Sky Survey (SDSS), and 14 bright DO stars whose spectra were secured at the Steward Observatory 2.3 m Bok telescope equipped with the Boller & Chivens spectrograph. To analyze these observations, we computed a new grid of non@ LTE, helium@rich model atmospheres and synthetic spectra using the codes TLUSTY and SYNSPEC (Hubeny & Lanz 1995). The best@fitting atmospheric parameters were obtained by first normalizing the observed and model spectra to a continuum set to unity, and then applying a χ2 minimization procedure to these normalized spectra. Figure 2 : This figure is similar to Figure 1, but for some white dwarfs exhibiting distinctive spectral features. 31 objects, such as SDSS J011346.77+002828.6, show traces of carbon. For these stars, the C IV !4658, !5801 and !5812 lines (indicated by thick marks) are simply excluded from the fits. Also, 14 objects, such as SDSS J101355.61–001396.4 and SDSS J003343.05+142251.4, contain hydrogen, either in a homogeneous or stratified configuration. In the former case, we infer the hydrogen abundance by number (NH/NHe), while in the latter case, we constrain the mass of the hydrogen layer floati | poster |
The coincident detection the connection between binary neutron (SGRBs) [1]. Given can exploit sample of SGRBs. bursts we of GW 170817 and GRB 170817A cemented gamma-ray waves, star (BNS) mergers and short-duration the low number of BNS mergers detected through gravitational this connection to study BNSs through the much larger distribution [4]. small [2]. [3] distribution The majority of SGRBs are found nearby a galaxy, which is usually deemed as the host if the probability of chance alignment is is very and this these binaries receive a kick to inform BNS properties, or the delay time The offset from the host sometimes large is consistent with the BNSs being the bursts’ progenitors, since at their formation. The host properties and the SGRB offset can be used such as the kick In the following, short with a machine-learning algorithm [5]. bursts recognized as short by older probability of chance alignment. To from HST, thus the the whole sample. observations we employ a sample of gamma-ray bursts classified as This sample is enhanced with other works. We pick as putative host the galaxy with the lowest date, we have analyzed only the hosts with archival results presented cover only a fraction of [1] L13 [2] 56 [3] 190 [4] 5220 [5] L20 [6] 220 [7] 770 [8] 2004 [9] 897 [10] orientations. [11] Abbott B.P., Abbott R., Abbott T.D. et al. 2017, ApJ, 848, Fong W., Berger E., Chornock R. et al. 2013, ApJ, 769, Zevin M., Kelley L.Z., Nugent A. et al. 2020, ApJ, 904, McCarthy K.S., Zheng Z., Ramirez-Ruiz E. 2020, MNRAS, 499, Jespersen C.K., Severin J.B., Steinhardt C.L. et al. 2020, ApJ, 896, Kormendy J., Freeman K.C. 2004, IAUS Thomas J., Saglia R.P., Bender R. et al. 2009, ApJ, 691, Church R.P., Levan A.J., Davies M.B. et al. 2011, MNRAS, 413, Hurley J.R., Tout C.A., Pols O.R. 2002, MNRAS, 329, Bovy J. 2015, ApJS, 216, 29 The assumption of isotropic orientations has been tested for a couple of edge-on late-type host, showing no much difference in the offset distribution w.r.t. those from arbitrary Possible explanations: - got the wrong host - missing dominant - missing part or - accretion star-black hole binaries) missing evolution populations (e.g. neutron of the halo satellite galaxies episodes during the host early-type K-S for host. The test 0.86 late-type hosts, and 0.14 for for F against a uniform distribution gives a p-value of late-type (blue) galaxy. offset Offset distributions as predicted by BNS mergers. Black dots indicate the observed SGRB s (burst ID in brackets). Colours indicate whether the host is an early- (red) or a BNSs? merging uniformly distributed. How to assess the positions of For each burst, offset. be if F should observed offsets were SGRB are consistent with the we take the fraction of merging BNSs within the SGRB If the observed offsets realizations of our synthetic distributions, then F The the the gravitational potential halo. For each host, from host luminosity [6,7]. is reproduced with a logarithmic-profile dark matter relations halo properties are derived through observational scaling The of the of a population single stellar the binary. evolving population merger with times work [8] BSE [9], with BNSs was produced for a previous compute we solar metallicity and a Kroupa IMF. From the code output and the kicks to the barycenter the of to the Binary neutron stars surface brightness and randomly oriented [10]. are randomly seeded into the potential according host galaxy. The initial orbits are assumed circular the The Each binary is merger. projected position possible SGRB offset. Galpy [11] until then kicked, and its orbit is integrated with at the merger is assumed to be a | poster |
Wrapping culture plates with Parafilm M® increases Caenorhabditis elegans growth1 Jessica H. Shinn-Thomasa, Sara E. Scangaa, Patrick S. Spicaa, Hardik K. Nariyaa, Emra Klempica,b, Mary R. Brocketta,c aDepartment of Biology, Utica College, Utica, NY; bDivision of Cardiac Surgery, University of Rochester Medical Center, Rochester, NY; cDivision of Microbiology and Immunology, Uniformed Services University, Bethesda, MD. • Parafilm M® is a moisture-resistant thermoplastic commonly used to seal agar media plates for a variety of model organisms. • Minimal research has evaluated the effects Parafilm wrapping could have on these organisms. Recent research in Arabidopsis thaliana cultures demonstrated that growth was affected by Parafilm wrapping and gas exchange may be affected as well (Banerjee et al., 2019, PLOS ONE). • Parafilm is used to seal Nematode Growth Media (NGM) agar plates on which C.elegans is cultured. We aimed to determine if Parafilm wrapping engendered developmental changes in C. elegans by comparing larval growth over 48 hours of animals cultured on Parafilm- wrapped and unwrapped control NGM plates. OBJECTIVE AND METHODS1 For Complete Published Work, Go To: 1Shinn-Thomas, J.H., Scanga, S.E., Spica, P.S. et al. Wrapping culture plates with Parafilm M® increases Caenorhabditis elegans growth. BMC Res Notes 12, 818 (2019). https://doi.org/10.1186/s13104-019-4854-3 A Figure 1. Larval growth over time. Median length (μm) of worms in each treatment group at 0, 18, 24, 36, and 48 h after L1 transfer to plates. Data are displayed as boxplots overlaid with scatterplots of individual worm lengths (open circles) at each time point. Bold line within each box shows median length, and box shows Q3 (upper quartile) and Q1 (lower quartile). n = 39 Parafilm and n = 41 control1 Median (IQR) length (μm) Parafilm Control ΔGrowth 764.25 (39.3) 726.35 (97.3) Growth rate 16.43 (1.3) 15.56 (1.7) • Wrapping culture plates with Parafilm significantly accelerated and increased larval growth, with a 0.87 μm/h increase in growth rate (~ 6%) and a 37.90 μm increase in the change in growth (Δgrowth; ~ 5%) over 48 h. • Investigators of all organisms should be aware that wrapping their experimental cultures with Parafilm may result in statistically detectable changes, such as in growth and possibly other developmental processes. RESULTS1 CONCLUSIONS AND IMPLICATIONS1 Parafilm wrapped one time around the circumference of a NGM culture plate Table 1. Worms in cultures wrapped with Parafilm showed significantly greater Δgrowth (Mann–Whitney U test, W = 472, p = 0.001) and a significantly faster growth rate (Mann– Whitney U test, W = 479, p = 0.002) than worms in the control group. Cohen’s d indicated a moderate impact of Parafilm wrapping on the Δgrowth and growth rate of C. elegans over 48 h (Cohen’s d = 0.75 and d = 0.74 respectively).1 | poster |
Analýza vybraných charakteristik geriatrické populace v České republice v mezinárodním srovnání PharmDr. Jan Kostřiba, Ph.D.1, PharmDr. Anna Lukačišinová, Ph.D.,2 Pranvera Apostoli, MSc.1, Brkič Jovana, MSc.1, doc. PharmDr. Daniela Fialová, Ph.D.1, 3 1 Katedra sociální a klinické farmacie, Farmaceutická fakulta v Hradci Králové, Univerzita Karlova 2 Oddělení hodnocení zdravotnických technologií, Státní ústav pro kontrolu léčiv, Praha 3 Geriatrická klinika 1. LF UK a VFN, 1. lékařská fakulta, Univerzita Karlova Úvod Podíl seniorů v evropské i světové populaci neustále narůstá. S tímto trendem každoročně roste také počet polymorbidních pacientů s předepsanou polyfarmakoterapií, s omezenými funkčními schopnostmi a geriatrickým syndromem křehkosti. Senioři představují specifickou skupinu populace, která je také náchylnější k různým polékovým reakcím. Ve snaze zvýšit kvalitu a bezpečnost geriatrické preskripce a minimalizovat rizika spojená s užíváním léčiv jsou v Evropě i celosvětově publikována a analyzována data o stárnutí populace v jednotlivých regionech a s tím spojenými charakteristikami a riziky týkajícími se geriatrické populace. Cílem této dílčí analýzy je odhalit a zdůraznit potřebu změn zdravotní a lékové politiky v jednotlivých zemích v kontextu vývoje společnosti jako celku. Metodika V rámci výzkumných projektů EU H2020 “EUROAGEISM” a EU COST Action IS 1402, jejichž společným cílem je zlepšit kvalitu života geriatrické populace, byla v této části práce zabývající se porovnáním a hodnocením demografických, zdravotnických a ekonomických analýz použita data z databází OECD Health Statistics 2019, Evropské komise Eurostat, Českého statistického úřadu a Ústavu zdravotnických informací a statistiky ČR. Výsledky Podíl výdajů na zdravotnictví k HDP vykazuje dlouhodobě v ČR mnohem nižší hodnoty než ostatní srovnávané země. Rovněž nízký podíl soukromých výdajů charakterizuje významný vliv veřejného financování a s ním spojenou důležitostí zodpovědnosti centrálních autorit na racionálním nastavení celého zdravotnického systému. Naděje na dožití při narození nejen v ČR stále roste, důležité je však porovnávat také podíl tzv. roků zdravého života bez zdravotních komplikací. V souvislosti s nízkou porodností dochází ve většině sledovaných zemí ke stárnutí populace a zvyšování podílu geriatrické části obyvatel. Dlouhodobou nemocí nebo zdravotním problémem trpí nadpoloviční většina geriatrické populace, roste i podíl vybraných chronických onemocnění jako je hypertenze či diabetes mellitus. Výsledky reflektují i míru racionality v užívání předepisovaných léčivých přípravků, které je v ČR jedno z nejvyšších v rámci sledovaných zemí. Více než 82 % populace starší 65 let, a dokonce více než 96 % populace starší 75 let užívá nějaké léčivé přípravky na lékařský předpis, přičemž průměr zemí EU je o 10 % nižší. Závěr Parametry geriatrické populace v ČR vykazují řadu společných charakteristik v rámci vyspělých zemí OECD i EU, ale i v rámci těchto srovnání vykazují mnoho specifik, která je třeba reflektovat nejen v individuálních léčebných postupech, ale také v utváření celonárodní zdravotní a lékové politiky. Poděkování Tento projekt vznikl v rámci výzkumných projektů EU H2020 “EUROAGEISM” a EU COST Action IS 1402 podpořených programem Horizon 2020 Evropské komise dle grantové dohody Marie Skłodowska-Curie č. 764632. | poster |
SimplificaƟon of a benthic ecological network in response to climate change stress E CO SY ST E M FU NC TI O N P U O R G T I A R T A N U A F O R C A M E NV IR O N M EN TA L CH AR AC TE RI ST IC S Microphytobenthos Standing Stock Net Oxygen ProducƟon Ammonium Flux Phosphate Flux PredaƟng and Scavenging Worms and Crustaceans Surface Dwelling Crustaceans and Gastropods Suspension and Deposit Feeding Bivalves Deposit Feeding Polychaetes Sediment Grain Size Sediment Porosity Sediment Organic MaƩer Content Sediment Mud Content Oxygen ConsumpƟon E CO SY ST E M FU NC TI O N P U O R G T I A R T A N U A F O R C A M E NV IR O N M EN TA L CH AR AC TE RI ST IC S Microphytobenthos Standing Stock Net Oxygen ProducƟon Ammonium Flux Phosphate Flux PredaƟng and Scavenging Worms and Crustaceans Surface Dwelling Crustaceans and Gastropods Suspension and Deposit Feeding Bivalves Deposit Feeding Polychaetes Sediment Grain Size Sediment Porosity Sediment Organic MaƩer Content Sediment Mud Content Oxygen ConsumpƟon Simon Thomas*, Ines Bartl and Simon Thrush Background Ambient Sediment Network Sea Level Rise + Sediment DeposiƟon Network Microbes Microphytobenthos Macrofauna •InterƟdal benthic sediments produce important ecosystem funcƟons such as nutrient cycling and primary producƟon •This forms an ecological network between the community, the surrounding sediment environment, and the ecosystem funcƟons produced The Problem Microbes Macrofauna Microphytobenthos •Climate change is creaƟng stressors such as sea level rise and terrigenous sediment deposiƟon •These stressors can impact benthic communiƟes, altering ecological networks and reducing resilience Sediment deposiƟon Sea level rise Sea level rise •In situ mesocosms •Convert interƟdal to subƟdal Sediment DeposiƟon •Collect sediment from catchment •Deposit 3mm layer SimulaƟng Climate Change Stress Research Aim Assess changes in benthic ecological network architecture in response to combined sea level rise and terrigenous sediment deposiƟon Node Type Environmental CharacterisƟc Ecosystem FuncƟon Macrofauna Species Group Number of ConnecƟons Strength of ConnecƟon 10% 30% 50% 70% 90% 0 1 2 3 4 5 Legend Results • Networks were built using mulƟple regression models for each funcƟon • We observed simplificaƟon of the network in response to stress • SimplificaƟon refers to a reducƟon in the number of nodes present in the network, the number of connecƟons between nodes, and overall network model strength • This represents a loss of resilience, and further stress could push the ecosystem to a Ɵpping point Network Metric Ambient Sediment Sea level Rise + Sediment DeposiƟon Number of Nodes 13 7 Number of ConnecƟons 15 8 Network Strength (average model adjusted R2 value) 0.86 0.35 + | poster |
esciencecenter.nl Powered by pioneering software TaxoTagger Cunliang Geng1, Sonja Georgievska1, Duong Vu2 1Netherlands eScience center, 2Westerdijk Fungal Biodiversity Institute ⚡ Conduct efficient semantic searches for precise results 🚀 Build vector databases from DNA sequences with ease 🛠 Extend support for custom embedding models effortlessly 🌐 Interact seamlessly through a user-friendly web app TaxoTagger is an open-source Python library for DNA taxonomy identification, powered by deep learning and semantic search 👉 Try the webapp demo at http://mycoai.org http://mycoai.org | poster |
Visit www.europepmc.org Follow @EuropePMC_news Contact helpdesk@europepmc.org Get in touch Public peer review landscape What is possible How to get there Recommendations ●Good quality metadata ●Common taxonomies ●Linking persistent identifiers (PIDs) ●Centralised resources ●Community buy-in What is missing ●Consistent metadata fields cross-methods ●Complete metadata in machine readable format ●Convergence on sentiment ratings Improving public peer review accessibility and reuse Melissa Harrison Europe PMC, EMBL-EBI, Hinxton, UK Europe PMC perspective Peer review information in Europe PMC What is on the Europe PMC roadmap Growth in open peer review materials Peer reviews were added as a Crossref content type in Nov 2017. As of Apr 2022 there are ~250,000 peer reviews registered with Crossref DOIs. The majority of peer review providers* are publishers, many of whom use the Publons peer review platform. * A list of publishers that provide open peer review materials is collated from various sources: (1) Publishers that register Crossref DOIs for ‘peer-review’ content type. (2) Publishers that provide publications with ‘peer review’ section in PMC XML. (3) Publishers listed in the following publications: Beck J, Funk K, Harrison M, et al. Publishing peer review materials. F1000research 7:1655 (2018); Wolfram, D., Wang, P., Hembree, A. et al. Open peer review: promoting transparency in open science. Scientometrics 125, 1033–1051 (2020). Europe PMC ●User research: what information about peer reviews do readers want to see? ●Investigate DocMaps and Sciety: what material can we retrieve and display? ●Investigate Crossref and DataCite: what metadata can we retrieve and display? Centralised sources Ways to share peer review materials There are a variety of ways publishers are exposing journal article peer reviews (see below)*. Additionally, there is a great diversity in approaches even within a single route, for example using content types other than ‘peer-review’ when registering DOIs with Crossref. Preprint peer reviews There are at least 30 organisations** conducting peer review of preprints. These evaluations are being distributed in various ways, including as overlay journals. A little under half are included in Sciety, an aggregator of preprint peer reviews, and just over a quarter register DOIs. ** A list of preprint peer review platforms that provide open preprint review reports or comments is collated from https://reimaginereview.asapbio.org/ and https://sciety.org/ websites. Type ●Recommendations ●Reviews ●Comments ●Author response Contributors ●Author/ORCID ●Institution/ROR ●Role (reviewer, author, editor) ●Journal/platform/community Timeline ●Date of review/response ●Version applicable ●VoR publication Sentiment ●Recommend ●Recommend with suggested revisions ●Refute/Disavowal ●Peer review status for preprints from open research platforms is indicated. ●Preprints and journal articles in Europe PMC are linked to peer reviews from external sources. Review links are displayed in a dedicated section on the preprint page. ●Search option for preprints with links to reviews is provided via Advanced search. Complete machine readable metadata for peer review materials Metadata and links to reviews available from a small set of centralised sources enables Europe PMC to retrieve the information and display it consistently across all content indexed. ●Global, open, free resource for life science literature ●Partner of PubMed Central USA ●Repository of choice for 37 international funders Publications and preprints in Europe PMC are linked to additional resources: Protocols and materials Citations Author’s ORCIDs Underlying data Peer reviews Funding information | poster |
Bees for the Future A. Freitas1, C. Ferreira1, C. Campanário1, F. Freitas1, students from 10.º2, 10.º4 and CEF611 1Escola Secundária Jaime Moniz, Funchal, Portugal Abstract In the academic year 2018/2019, students from Escola Secundária Jaime Moniz studied the importance of bees for the future using digital tools, platforms and a simulator that represented the influence of the increase or decrease of flowers to the bee population and the other way around. They also established collaboration with their community to research their level of awareness, to collect knowledge from experts and to analyze the health of the bee population in their island. For this, they collected information in a series of forms, which they shared in the Globallab platform with students from other parts of the world, gaining awareness of the relevance of problems at local and global levels. In the process, students visited a honey producer and organized a conference with the beekeeper. In the end, each group of students created a final product to present to the educational community, raising awareness of the problem studied. The products created were posters, leaflets, models, games, beds of honey plants, hives and hotels for bees. Keywords Bees; biodiversity; biosphere; ecosystem; honey. | poster |
Parental and Peer Influences on Adolescent Smoking Initiation 1 Kuang Hock Lim1, Pei Pei Heng1, Hui Li Lim2, Sumarni Mohd Ghazali1, Yoon Ling Cheong1, Chee Cheong Kee3, Chien Huey Teh1, Balvinder Singh Gill1, Jia Hui Lim 4 1. Institute for Medical Research, National Institutes of Health, Ministry of Health Malaysia 2. Hospital Sultan Ismail, Johor Bharu, Ministry of Health Malaysia 3. Sector for Biostatistics and Data Repository, National Institutes of Health,Ministry of Health Malaysia. 4. Monash University Malaysia, Jalan Lagoon Selatan,47500 Bandar Sunway, Selangor Darul Ehsan P. 59 NMRR NO:12-1210-12399 INTRODUCTION: • The smoking habit is learnt and initiated in adolescence. Among daily smokers, over 85% attempted first cigarette at age of 18 ; almost 65% began smoking regularly by the same age 1. • Malaysian National Health and Morbidity Survey in 2015 reported that 70% of adult smokers started smoking before the age of 18 2 . • Ample studies have documented that parents and peers are dominant factors contribute to smoking initiation among adolescents 3 . • This study aimed to determine the actual causation factors of smoking initiation among non-smoking school-going adolescents METHDOLOGY: • Study Design: Prospective Cohort • Study Population: Non-smoking secondary school-going adolescents of form 1 (13 years), form 2 (14 years) and form 4 (16 years) • Study Location: Kota Tinggi district, Johor. • Sampling: Multistage, proportionate to size and cluster sampling . Respondents were followed-up for one year. • Measures: Dependent variable -> smoking status at follow-up (Smoked at least once in past 30 days identified as current smokers). Independent variables -> ―Number of best friends who smoke‖ (0, 1-5), and ―parent(s) smoking status‖ (Yes/No). • Data analysis: Descriptive analysis and Multivariable Logistic Regression was employed to determine the associated factors. RESULTS: Out of the 1682 non-smoking respondents at baseline, a total of 1282 (74.1%) participated at follow-up. Approximately 1 in 10 non-smoking Malaysian youth initiate smoking after a period of one year. Factors significantly associated with smoking initiation (Univariate Analysis) Risk of Smoking Initiation (Multivariable Analysis) Male ( Female as reference) 95% CI (2.93-12.95) Lower secondary (Upper secondary as reference) 95% CI (1.05-2.93) Smoking Parent/s 95% CI (1.06-2.95) DISCUSSION: • This was the first study to determine the factors influencing smoking initiation among non-smoking school-going adolescents in Malaysia. • About 1 in 10 non-smoking Malaysian youth initiated smoking after one year, which is higher than the 5% and 7% among cohorts reported in Portugal 4. • Smoking parent/s was more likely to influence smoking initiation among non-smoking adolescents, which was in consistent with the study among Taiwanese youth 5 that concluded that parents were the dominant role models for the smoking habit development among children. Parents who smoke in front of children indirectly provide the impression that smoking is a normative behaviour among adults.6 This positive finding also lends support to Bandura’s Cognitive Social Theory which posits that we tend to adopt behaviours that we learn from observing others, especially our role models for whom we have much respect such as our parents/guardians. • Our study found insignificant influence of peers on smoking initiation, in-line with several studies conducted overseas 7, which was contrary to several systematic review on longitudinal studies reporting causal-relationship between peer smoking and smoking initiation and non-smoking youth 8 . However, the influence of peers should be tested in more future studies. CONCLUSION: • The study revealed that parental influence was more dominant than peer influence with regards to smoking initiation. • Therefore, intervention program should involve parents/guardians to enhance the success rate and reduce the incidence of smoking among non-smoking schoo | poster |
Spectral Interleaving with Quantum Cascade Laser Frequency Combs Michele Gianella1, Akshay Nataraj1, Béla Tuzson1, Filippos Kapsalidis2, Mattias Beck2, Stéphane Schilt3, Thomas Südmeyer3, Jérôme Faist2, Andreas Hugi4, Lukas Emmenegger1 1. Laboratory for Air Pollution / Environmental Technology, Empa, Überlandstrasse 129, CH-8600 Dübendorf, Switzerland 2. Institute for Quantum Electronics, ETH Zurich, CH-8093 Zürich, Switzerland 3. Laboratoire Temps-Fréquence, Université de Neuchâtel, Avenue de Bellevaux 51, CH-2000 Neuchâtel, Switzerland 4. IRsweep AG, Laubisrütistrasse 44, CH-8712 Stäfa, Switzerland Introduction Frequency combs based on quantum cascade lasers (QCLs) provide direct access to the mid-infrared spectral range, where the strong and characteristic rovibrational absorption bands of many molecules are located. For gas-phase spectroscopy, however, the large comb spacing (5-15 GHz) of these devices – much larger than the absorption lines of simple molecules at atmospheric pressure or below – is problematic. Phase-sensitive, dual-comb configuration. Free-running QCL frequency comb FC1 (sample comb) probes the sample; FC2 serves to produce multi-heterodyne beat note signals on pho- todetectors, giving access to all optical frequencies simulta- neously, no moving parts required (Fig. 1). Multi-heterodyne beat note signal. Comb lines from FC1 (ν1j) and FC2 (ν2j) produce beat notes (fj= ν1j- ν2j) in measured photocurrent. Sample attenuation and phase shift at ν1j are encoded in beat note amplitude ratio at fj (Fig. 2). Spectral interleaving Spectral resolution of frequency comb measurements is generally limited by the line width of the comb lines (<1 MHz). Spectral sampling period is given by the comb frequency spacing (5-15 GHz typically) and can be reduced by continuous (or step-wise) shift of the frequen- cy comb spectrum (through current modulation) and interleaving (Fig. 3). Demonstration: Methane (CH4) absorption and phase-shift spectrum (at 100 mbar) measured in 120 ms (Fig. 4). Linear trend in phase due to gas cell windows. Spectral resolution: 0.001 cm-1 (30 MHz). Coverage: up to 25 cm-1. Fig. 1. Phase-sensitive dual-comb configuration. Fig. 2. Left: Multi-heterodyne beat note signals generated by the two combs, FC1 and FC2, with and without sample (polypropylene foil in this example). Right: derived transmission spectrum. Fig. 3. Spectral interleaving by continuous or step-wise tuning of the (discrete) frequencies of the comb. Fig. 4. Transmission and phase-shift spectrum of pure methane shown between 1208 and 1221 cm-1 (100 mbar, 25°C, 14 cm path length). The different colours correspond to the range covered by individual comb lines. Applications Potential applications include mid-infrared spectroscopy requiring: - high spectral resolution (<0.001 cm-1) - broadband coverage (>20 cm-1) - 100 ms time resolution (10 ms should be possible with 0.001 cm-1 resolution) Comb line frequencies of free-running sample comb (FC1) are given by 𝜈1𝑗(𝑡) = 𝜈1 0(𝑡) + 𝑗∙Δ𝜈1(𝑡) 𝜈1 0: offset frequency 𝑡: time (laser current) 𝑗: comb line number Δ𝜈1: comb line spacing Fig. 5. Zoom-in of shaded region in Fig. 4 after etalon removal. Examples • time-resolved breath analysis • gas-phase reaction kinetics • … Funding: Swiss National Science Foundation, Bridge Discovery program, Grant 20B2-1_176584 References A. Hugi, G. Villares, S. Blaser, H. C. Liu, and J. Faist, “Mid-infrared frequency comb based on a quantum cascade laser,” Nature 492, 229–233 (2012). G. Villares, A. Hugi, S. Blaser, and J. Faist, “Dual-comb spectroscopy based on quantum-cascade-laser frequency combs,” Nature Communications 5, 1–3 (2014). | poster |
Myco-Materials: An Investigation Into the Properties and Applications of Mycelium-based Composites Emaline Ouellette, Keira Reidy, Chase McDivitt, Nick Ascione, Nelson Mathis, Ryan Collins Advisors: Dorlan Curtis Jr., Gustav Wellin, Allan Jones Introduction Results Discussion Literature Cited Acknowledgements At The Island School, mycology-based research has focused on the cultivation of Oyster mushrooms (Pleurotus ostreatus) to model sustainable agriculture and biomaterial production in Small Island Developing States (SIDS). Due to large scale importation of food and goods, as well as agricultural residues, there are widely available substrates for mushroom production such as cardboard, banana straw, and coffee grounds. Mushrooms are a climate resilient food source as they can be grown indoors under controlled conditions (light, temperature, relative humidity), and are less impacted by drought or reduced rainfall. This research studied the ability of Phoenix Oyster mushrooms spawn myceliate various forms of locally available biomass in order to produce food and novel myco-materials. By varying substrate-fungi combinations, it resulted in different final material properties in the myco-composites. SPULP performance, as a myco-composite, under compression, flammability, and moisture retention tests show equal or superior results when compared to other myco-composites such as SBSTRW or COF. In the flammability tests, SCARD performed the best; it only lost 7 grams of mass after 120 seconds of exposure to flame. COF performance in moisture retention the best in water retention as it only absorbed about 25 grams of water. In compression tests, SPULP performed the best, experiencing zero displacement under Attias, N., & Danai, O., & Tarazi, E., & Idan, P., & Grobman, Y. J. (2019). Implementing bio-design tools to develop mycelium-based products. The Design Journal, 22(sup1), pp.1647-1657. Girometta, C., & Picco, A. M., & Baigeura, R. M., & Dondi, D., & Babbini, S., & Cartabia, M., & Pellegrini, M., & Savino, E. (2019). Physico-Mechanical and Thermodynamic Properties of Mycelium-Based Biocomposites: A Review. Sustainability, 11(281) Karana, E., Blauwhoff, D., Hultink, E. -J., & Camere, S. (2018). When the material grows: A case study on designing (with) mycelium-based materials. International Journal of Design, 12(2), 119-136. Tarko, D. B., & Sirna, A. M. (2018). Substrate optimization for cultivation of Pleurotus osteatus on lignocellulosic wastes (coffee, sawdust, and sugarcane bagasse) in Mizan- Tepi University, Tepi Campus, Tepi Town. Journal of Applied Biology & Biotechnology, Vol. 6(04), pp. 14-11) Dorlan Curtis Jr., Gustav Wellin, Allan Jones, Ruben Gomez, The Tingum, Chores Team, Alexis Saunders, The Farm Team, The Island School, CEI, The Ray Dalio Foundation The fundamental questions of this research project were what are the material properties of different substrate-fungi combinations and how can we utilize MDD to create furniture from mycelium-based composites? The research objectives are: 1) To pilot mycelium-based composite research utilizing locally available substrates 2) To produce novel and exotic materials for eco-conscious designers 3) To model sustainable and climate-resilient agriculture with cultivation of edible mushrooms. Research Rational Growing Myco-Composites and Edible Mushrooms Substrates were prepared and pasteurized in 80-100°C water for 60 minutes, and were then inoculated with 10% by weight (w/w) of Phoenix Oyster mushroom spawn and 5% w/w flour or cornstarch as a growth supplement. The inoculated substrates were mixed and packed into either fruiting bags, for edible mushroom cultivation, or a grow design mold for myco-composite production. The fruiting bags and grow molds were then incubated in the dark/low light and 65% relative humidity (RH) for 4-5 weeks to allow the mycelium to colonize the substrates. After the incubation period, the fruiting bags were placed in a fruiting chamber for 2-3 week | poster |
Using Tablets to Assess Working Memory Capacity in School Settings Kaisa Kanerva1, Ilkka Kiistala2, Noona Kiuru2 1University of Helsinki and 2University of Jyv¨askyl¨a kaisa.kanerva@helsinki.fi Introduction Working memory (WM) refers to simultaneous storage and processing of information during an ongo- ing task (Baddeley, 2002). Capacity of domain-general central executive component is not sufficiently assessed by simple span tasks, such as digit span. • Complex span tasks (e.g., Reading span task, (Daneman & Carpenter, 1980)) WM deficits are observed in broad cognitive impairments, such as SLI and childhood aphasia, and also in genetic syndromes such as Down syndrome (verbal WM) and Williams syndrome (visuo- spatial WM) (Majerus & Van der Linden, 2013). • WM deficits are common in different learning difficulties such as dyslexia and dyscalculia • Individual differences in WM capacity are related to academic achievement and scholastic skills, and to children’s classroom behavior (Gathercole, Lamont, & Alloway, 2006) WM is assessed using different types of tasks and batteries: • Standard paper-and-pencil tests, behavioral ratings (WMRS), computerized test batteries (AWMA) • Commonly used WM tasks are Complex Span tasks (Reading Span task, Counting Span task), backward span tasks (Digit Span task) Figure 1: On level three of the Counting span task, the subjects were presented with series like the one shown here followed by a screen asking how many circles were displayed. Why tablet tasks? • Self-reliant group testing allows large sample sizes and screening • Computer-paced WM tasks are better predictor of cognitive performance than self-paced WM tasks (McCabe, 2010) • Reaction times are more realistic when no mouse is needed • However, there can be distraction, noise and technical problems in a classroom during assessment Main Objectives The aims of the study were to develop self-reliant WM tasks for tablet and to examine (i) the process of using tablets in WM assessment in a classroom in a research setting and (ii) the quality of the developed WM tasks as assessment tools • Predictive validity: tasks’ relationships with scholastic achievement scores • Concurrent validity: the tasks’ relationships with each other and individual WM performance • The reported distraction in the classroom during the testing • The effect of class on WM performance Methods This study is part of a broader Tikapuu research project which will be reported elsewhere. Participants • A total of 705 sixth grade (12-year-old) children from 53 classes in 30 schools (63 testing sessions) • Subsample of 190 children in individual testing (Digit Span reported here) • In a testing session there were from 9 to 30 children (mean group size = 18 pupils) WM span tasks for tablet • Counting Span task (Figure 1), Reading Span task Academic Achievement • Grade Point Average, Math test, Literacy test Individually administered STM/WM tasks (N = 190˜) • Digit Span Forward and Digit Span Backward Figure 2: Tablet carrying case and charging station 30 tablets with the experiment application installed were used in 63 testing sessions. To ensure the devices could be used in the sessions without interruption their battery needed to be charged every night. A carrying case was built for the tablets (Figure 2). To ensure no data was lost, the data logs were copied from the tablets by a Raspberry Pi computer into a flash drive. Tablets used in testing were Samsung Tab 3 (GT-P5210) devices. They were running Android 4.2.2 with minimal set of features turned on. For example, no network connection was needed during the tasks. The tasks were run on top of OpenSesame Runtime for Android (version 2.8.3). The tasks were designed with OpenSesame, an open-source experiment builder (Mathˆot, Schreij, & Theeuwes, 2012). Results CountingSpan ReadingSpan Literacy Math FluidIntelligence ReadingSpan 0.41*** Literacy 0.41*** 0.45*** Math 0.46*** 0.33*** 0.43*** FluidIntelligence 0.39*** 0.32*** 0.26*** | poster |
Lotte Wilms, Andreas Degkwitz, Caleb Derven, Marian Lefferts, Kirsty Lingstadt, Liam O’Dwyer, Demmy Verbeke & Digital Humanities and Digital Cultural Heritage WG Participants 56 participants - 54 institiutions - 20 countries Full report available at doi.org/10.5281/zenodo.3247286 3. Select youractivitieswisely Libraries are most active in data capture, creation and storage. Build on your (collection) strengths to decide what works best for you. 1. Createa goal or visionforyourlibrary A defined framework clarifies your goal and manages expectations of partners. Set up your organisation with enough resources to make sure you can also reach this goal. 2. Measureyourimpact Identify early on how you will measure your achievements and impact. This will help you define what works well and what needs to be re-evaluated. 4. Reflectthefull breadthof yourcollections By broadening your scope to the full width of your collection your DH offering can be strengthened. Work from your strenghts and make access as easy as possible. 5. Have confidencein yourexpertise As the creator of your digital collections, you are the expert. Your are therefore the ideal partner, as you know what has been digitised, how it’s been digitised, what licenses apply, what works well and what probably wouldn’t. Strengthening the position of libraries as partner in DH will be a a core theme for the WG for the next two years. 6. Involveallyourcolleagues, notjusttheobviousones DH activities are most succesful if they are supported by a large number of library staff. Work together to build your skills and ideas. 7. Collaborate, collaborate, collaborate! Building your network in DH is crucial, as collaboration is key. Once you have defined your goals and activities go out and disseminate your data, your team and you ideas. Special thanks to Friedel Grant for the design of all graphs, tables and the word cloud. We also wish to thank all contributors and our WG’s members for their input. | poster |
Task Area Infrastructure Operations: Integration und Koordination der Text+ Infrastrukturentwicklung und Vernetzung mit der NFDI STRUKTUR VON TEXT+ AUFGABEN VON IO IO ist für die Integration und Koordination der Infrastruktur- entwicklung von Text+ verantwortlich – auch mit Blick auf die NFDI insgesamt – und arbeitet eng mit den drei Datendomänen zusammen. Die Aufgaben sind in Maßnahmen entlang der FAIR-Prinzipien strukturiert. Hinzu kommen Communityaktivitäten und Software Services. Besondere Aufmerksamkeit kommt den AGs sowie den folgenden Themen zu: • Werkzeuge für die interne Projektarbeit (z.B. Cloud, Projektmanagement, Instant Messaging) und für den Austausch mit den Text+-Communities (z.B. Webportal, Helpdesk) • Interoperabilität von Angeboten und Diensten (Data Services, Community Activities, Software Services) • Cross Domain-Topics mit den drei Datendomänen, insbesondere im Rahmen von AGs (z.B. AG Registry) • Anschlussfähigkeit zu anderen NFDI-Angeboten, insbesondere zur Gruppe der geistes- und kulturwissenschaftlichen Konsortien und Konsortialinitiativen mit NFDI4Culture, NFDI4Memory und NFDI4Objects. Das NFDI-Konsortium Text+ für sprach- und textbasierte Forschungsdaten adressiert derzeit drei Datendomänen: Sammlungen, Lexikalische Ressourcen und Editionen. Dazu kommen zwei datendomänenübergreifende Arbeitsbereiche: Administration sowie Infrastruktur/Betrieb, kurz IO. INTEGRATION und KOORDINATION Eine wesentliche Herausforderung wissenschaftlicher Forschungsdateninfrastrukturen liegt • in der Vermittlung zwischen Anforderungserhebung und Angebotsentwicklung und • in der Abwägung zwischen der Nutzung/Adaption von bestehenden Lösungen und der Konzeption von neuen Lösungen. Idealerweise gelingt ein Match zwischen den – oftmals vielfältigen – fachwissen- schaftlichen Anforderungen einerseits sowie den zur Verfügung stehenden Ressourcen und insbesondere bereits vorhandenen Komponenten, Methoden und Standards andererseits. Text+ Community Data Domains Task Area IO NFDI NFDI- Sektionen Metadata & Common Infrastructure Das NFDI-Konsortium Text+ wird gefördert durch die Deutsche Forschungsgemeinschaft (DFG) unter der Projektnummer 460033370. Kontakt: textplus-operations-office@lists.gwdg.de Poster: Task Area Infrastructure Operations: Integration und Koordination der Text+ Infrastrukturentwicklung und Vernetzung mit der NFDI Inhalt: Text+ Infrastructure Operations Partner Verantwortlich : Stefan Buddenbohm (0000-0002-3469-6101), Andreas Henrich (0000-0002-5074-3254), Alexander Steckel (0000-0001-7066-1734), Regine Stein (0000-0003-3406-5104) Lukas Weimer (0000-0001-6919-3646 Event: Infrastructure/Operations für das Text+ Plenary 2022, 12./13. September 2022, Mannheim Text+ ist Teil der Measure AGs (Stand: 9/22) Wen kann ich ansprechen? M1 Findability FCS, Text+ Registry, NFDI-Sektion Metadata, Provenance and Terminologies AG Search and Harvesting Thomas Eckart, Tobias Gradl, Gerhard Heyer, Oliver Schonefeld M2 Accessibility NFDI-Sektion Common Infrastructure AGs: Identity and Access Management, Longterm Archiving and Access, Persistent Identifier George Dogaru, Stefan E. Funk, Bernd Schlör, Tobias Steinke M3 Interoperability and Re-Usability LOD, GND-Agentur, NFDI-Sektion Common Infrastructure AG Data Integration, NFDI- Sektion Metadata, Provenance and Terminologies AGs: Cookbooks, Guidance and Best Practices, Terminology Services and Semantic Interoperability Susanne Al-Eryani, Marie Annisius, Stefan Buddenbohm, Barbara Fischer, Eva-Maria Gerstner, Tobias Gradl, Andreas Henrich, Jürgen Kett, Uwe Sikora, Regine Stein M4 Community Activities Helpdesk, Webportal, Kommunikationsstrategie Stefan Buddenbohm, Sonja Friedrichs, Melina Jander, Alexander Steckel, Annika Wienert M5 Software Services Software Development, NFDI-Sektion Common Infrastructure AG RSE George Dogaru, Tibor Kálmán, Philipp Wieder Leitung: Regine Stein (SUB Göttingen), Andreas Henrich (Universität Bamberg), TA-Koordination: Stefan Buddenbohm (SUB Göttingen) Qu | poster |
Visit the reference links What is Bioethics? Bioethics refers to ethical, social and legal issues raised in medicine and biological researches. Bioethics is concerned with fair and equal consideration for human rights, animal rights, and the environment. Bioethics is the combination of biological knowledge and human values. Principles of bioethics provide a general framework for ethical analysis while using human object resource: 1) Individual autonomy (the ability of participants to make decisions for themselves) 2) Beneficence (the obligation to “do good” for the participants); 3) Nonmaleficence (the obligation to avoid causing harm to the participants) 4) Justice (the value of distributing benefits and burdens fairly). Background The term „bioethics‟ was first introduced by Van Rensselaer Potter in 1971. The great demand for medical ethics was understood in reaction to some negative events, such as the research experiments on human subjects committed by the Nazis. Medical ethics (ethical issues in health care) Research ethics (ethical issues while conducting research) Environmental ethics (ethical issues regarding the relationship between human activities and the environment) Public health ethics (ethical issues in public health) Bioethics When do I need animal ethics approval? Performing the scientific procedures including killing, handling, affecting the habitat of, or otherwise interacting with an animal always requires animal ethics approval. Even observational studies may require animal ethics approval. In determining whether approval is required, consider whether any aspect of the life or death of the animal would be affected by the scientific activity. The Declaration of Helsinki (DoH) was first adopted at the 1964 WMA General Assembly in Helsinki. Its main focus was the responsibilities of researchers for the protection of research subjects. At present, National Institutes of Health (NIH), the Food and Drug Administration (FDA), the National Science Foundation (NSF), the Environmental Protection Agency (EPA), and the US Department of Agriculture (USDA) have ethics rules for funded researchers. Human cloning Body modification Gene Therapy Institutional Review Board Many institutions (e.g. BSMMU, BAU, IUB) of Bangladesh have Institutional Review Board (IRB). IRB is a committee that approve, monitor and review all types of research that include human and animal. National Research Ethics Committee (NREC) and Bangladesh Bioethics Society (BBS) are governmental and non governmental IRBs of Bangladesh respectively. Conclusion Researchers must be aware of ethical issues if they use living organism in research works. Soaibur Rahman, Rajabul Islam Kamol, Debajit Ghosh, Reduan Raihan, Ashraful Mia, Tanbir Ahammed Department of Genetic Engineering and Biotechnology, East West University References https://www.niehs.nih.gov/research/resources/bioethics/index.cfm https://www.niehs.nih.gov/research/resources/bioethics/whatis https://www.iep.utm.edu/bioethic/#SH2a https://www.who.int/ethics/Ethics_basic_concepts_ENG.pdf https://staff.unimelb.edu.au/research/ethics-integrity/animal-ethics/FAQs/when- do-i-need-animal-ethics-approval Are you doing research on living organism? You must know Bioethics | poster |
2021_OSC: Poster Abstract Poster title: "Small but sustainable? Scholar-led journals and open access” Project team: Christian Katzenbach (HIIG), Frédéric Dubois (HIIG), Patrick Urs Riechert (HIIG), Marcel Wrzesinski (HIIG), Nicole Waidlein (ZBW) Cooperating institutions: Humboldt Institute for Internet and Society (HIIG), ZBW - Leibniz Information Center for Economics Abstract: In Germany, stakeholders favour a few strategies to foster open access transformation: Library consortia negotiate (national) licensing models with major publishers; infrastructural service providers focus on flipping journals and therefore cater to the needs of renowned publishing projects. At the same time, for public research funding academic reputation (still) seems a key criterion. In doing so, major advantages of electronic publishing and bibliodiversity are given away, which include supporting innovative publication projects (inter-/transdisciplinary contexts, non-profit models, publications focusing on emerging topics, peripheral-local publication initiatives, small-subject-based initiatives) and developing new publication formats, tools and workflows (community-based and cooperative). The project “Innovative Open Access in Small Sciences (InnOAccess)” (June 2019 - February 2021; funded by the DFG) responds to these challenges by analysing the market of scholar-led, non-APC journals in Germany, developing reusable technical workflows for smaller publishing projects and testing new, interlocking financing models. One section of the poster features the results of a survey (sample size = 101) on the state of scholar-led, non-APC journals in Germany: How are they governed, staffed and funded? What are the budgetary options? Here it became clear, for example, that one-size-fits-all solutions do not work, mainly because publication cultures are as different as their publishing institutions. Particularly publishing projects beyond university infrastructures seem to have found creative financing opportunities and technical solutions from which the field of scholar-led-publishing as a whole can profit. The poster furthermore outlines, based on the findings of the survey and a systematic evaluation of existing business models, how technical workflows and a modular approach to journal financing contributes to sustainable publishing. This includes a streamlined journal workflow based on open source applications, emphasising cooperative practices and using community-based know-how. Addressing the precarious funding situation of scholar-led, non-APC journals, the poster introduces a set of financing opportunities that have been tested and are deemed manageable with regard to the needs and administrative capacities of this journal segment. In total, the poster sheds light on the precarious situation of scholar-led journals in Germany, emphasizes their importance for the open access ecosystem and offers insights on how to improve their situation in a practical fashion. | poster |
70 80 90 100 00:00 01:00 02:00 03:00 04:00 05:00 06:00 07:00 08:00 09:00 10:00 Temperature of the die (°C) Time (min) Adaptation of pelletizing conditions to a set of agricultural waste from Senegal and Côte d’Ivoire This study has received funding from the European Union’s Horizon 2020 Framework Programme for Research and Innovation under Grant Agreement no 101000762 for the Bio 4 Africa project. B. RABDEAU1, M. CAMPARGUE1, L. G. NDIAYE2, B. K. YAO3, C. BROU3, O. BEDZO4, P. ROUSSET5, K. TYBIRK6, G. JANNOT1, J.M. COMMANDRE5, C. DUPONT7 ____________________________________________________________________________________________ 1RAGT Energie, 2UASZ Université Assane Seck de Ziguinchor, 3INP-HB Institut National Polytechnique Felix Houphouet-Biogny, 4Celignis Limited, 5CIRAD UR114 BioWooEB, 6Food & Bio Cluster Denmark A.S, 7IHE Delft Institute for Water Education Under-exploited agricultural by-product Palm seed shells (a) Cashew nut shells (b) Peanut shells (c) Millet stalks (d) Cocoa pods (e) Raw physical properties not adapted to their final use High moisture content Not stabilized Low bulk density Inadequate particle size Not homogenous Potential applications Clean energy production Clean cooking Animal feeding production Soil amendment production Need to densify/pelletize What are the best pelletizing conditions and adaptations ? Material and methods Feedstock selection Drying at 40°C Shredding at 10mm Grinding at 3mm Mixing during 20min Pelletizing at 6mm : Moisture content (12-16%) Compression ratio (5-14) Characterisation of biomasses Physical (moisture content, bulk density, particle size distribution) Thermochemical (ash content, heating value, volatile matter) Chemical (fixed carbon, C, H, O, N, S, Cl, metals and macromolecules) Characterisation of pellets Fines content (%) Mechanical durability (%) Bulk density (kg/m3) Pellet length & diameter (mm) 30 Pelletizing trials : iterative steps in order to optimize pellet quality Cooling Photos of different pellets produced with peanut shells 16% 14% 16% 12% Moisture content 8 9 5 5 Compression ratio 6% 10% 25% 40% Fines (lower is better) 95,5% 81,3% 83,7% 43% Mec. dura. (higher is better) 696 kg/m3 680 kg/m3 675 kg/m3 588 kg/m3 Bulk density (600-750 kg/m3) Purpose Biomasses tested during the study Flat-die pellet mill used for the trials (3kW-KAHL) Preliminary results Photos of the best pellets obtained for four biomasses Cocoa pods Millet stalks Peanut shells Palm seed shells Biomass 14% 13,5% 16% 12% Moisture content 10 6,5 8 12 Compression ratio 99,2% 98,8% 95,5% 88,1% Mec. dura. 741 kg/m3 703 kg/m3 696 kg/m3 733 kg/m3 Bulk density Findings about pelletizing trials Best pelletizing conditions can be determined through iterative pelletizing trials Adequate combinations of moisture content and compression ratio differ greatly between biomasses : the quantity of water to add and the pellet mill die have to be adapted for each biomass Cashew nut shells : pellets with poor physical quality due to its high oil content Palm seed shells and peanut shells : promising results but can be improved Millet stalks and cocoa pods : adequate pellet quality with different pelletizing conditions Conclusion Observations : Adequate pellet quality results have been achieved for millet stalks and cocoa pods but it can be improved for the others. Prospects : potential ways to improve pellet quality in future trials Use of different pelletizing binders Blending of different biomasses together Pelletizing trials on pyrolyzed biomasses Power curves and die temperature during pelletizing trials of 5kg Peanut shells Cocoa pods 0 1 2 3 4 00:00 01:00 02:00 03:00 04:00 05:00 06:00 07:00 08:00 09:00 10:00 Power (kW) Time (min) Palm seed shells Millet stalks | poster |
We identified a range of perceived challenges encountered while undertaking WPBA with suggested solutions from the trainees including earlier provision of tailored support, enhanced educational supervision, more time to complete learning logs and sensitivity to culture and disability at all levels of training. The solutions are aimed at supporting and overcoming potential challenges to undertaking WPBA during GP speciality training. As this was a retrospective study with trainees’ experiences spanning years, some of the suggested changes or interventions may already be in place. Experiences of General Practice trainees undertaking Workplace Based Assessments who have received a developmental outcome at their Annual Review of Competency Progression (ARCP) SAPC 52nd Annual Scientific Meeting, Bristol 3-5 July 2024 Membership of the Royal College of General Practitioners (MRCGP) is awarded when a UK doctor has satisfactorily completed specialty training for general practice. Workplace Based Assessment (WPBA) is one of the tripos of the integrated assessment system. Trainees are required to provide evidence of learning and professional development which is recorded in the Portfolio which is assessed at an Annual Review of Competence Progression (ARCP) panel. Trainees are awarded an ARCP Outcome at panel: •Outcomes 1 and 6 reflect satisfactory progress in achieving the required capabilities for the stage of training as defined in the curriculum/all competencies to complete training. •Outcomes 2 and 3 reflect development of specific capabilities is required, without or with additional training time. Over the past four years there has been an increase in the number of outcome 2s and 3s awarded. We explored experiences of GP Trainees undertaking WPBA to understand their experiences including perceptions of why they felt they had been awarded an Outcome 2 or 3. The Approach Authors: Dr Joseph Akanuwe1, Dr Julie Pattinson1, Dr Sureyya Sonmez Efe2, Dr Kim Emerson3, Dr Andrew Wright3, Dr Shahid Merali3, Dr Bryony Sales3, Tom Anstey3, Dr Attiya Khan3, Prof A. Niroshan Siriwardena1,3 1. Community and Health Research Unit, University of Lincoln 2. School of Social and Political Sciences, University of Lincoln, 3. Royal College of General Practitioners (RCGP) Results Design We used a qualitative design and an inductive approach employing Systematic Grounded Theory which employed a set of inductive methods to inform theory development and results. Recruitment and Participants We recruited a purposive sample of 20 GPSTs of different abilities, stages of training and demographic characteristics that had a previous ARCP outcome of 2 or 3. The RCGP were gatekeepers and advertised the study through their e-portfolio. This was enhanced by a snowballing technique, with participants already identified, serving as key informants to recruit further eligible participants to the study. Ethical approval The study was given ethical approval by the University of Lincoln Research Ethics Committee. Interviews and analysis Participants contacted the researchers via e mail to express interest, receive further information and give informed consent. The researcher arranged interviews online Via Teams. Data were collected using semi-structured interviews lasting 40-70 mins. Interviews were recorded by Dictaphone, transcribed verbatim and analysed using a grounded theory approach facilitated by NVivo 14 software. Data collection and analysis stopped when data saturation was reached. The Problem Conclusion Funding acknowledgement This abstract presents independent research commissioned by the RCGP. The views and opinions expressed by authors in this publication are those of the authors and do not necessarily reflect those of the RCGP. Contact: Dr Joseph Akanuwe Email: jakanuwe@Lincoln.ac.uk | poster |
Fusing marine radioactivity mapping and geochemical data using state-of-the-art GIS technology 1 Centre for Research and Technology Hellas (CERTH), Athens, Greece 2 National and Kapodistrian University of Athens, Zografou Campus, Athens, Greece 3 Durham University, Durham, United Kingdom INTRODUCTION RAMONES [1], an EU H2020 FET Proactive Project, seeks to develop and deploy a new set of prototype, AI-driven instruments for continuous and in situ measurements of natural and artificial radioactivity in the marine environment. A main objective of the project is to introduce a conceptual methodology to investigate the potential connection between radioactivity and hydrothermal activity and develop a properly designed Risk Information System (RIS), including geospatial mapping among other features (see Fig. 1). In the present work, in situ measurements in the coastal zone of Paleochori in Milos Island in Greece are used to develop the first stage of the RIS, where various layers of data will be fused under one grand-unified scheme. METHODOLOGY • GIS (Geographic Information System) is a framework used for the collection, storage, management, analysis, and visualization of spatially distributed data. • In a recent mission at Paleochori Bay, geospatial data were collected using the RAMONES-developed γ-Sniffers (CZT- based γ-radiation spectrometers, see Fig. 2) homogenized and integrated into the relational File Geodatabase (FGDB). • In addition, samples of sediments were collected and measured with a high- resolution HPGe spectrometer. • The FGDB and the RIS will be enriched with new measurements each time the RAMONES instruments operate. Figure 1 / Design implementation of RAMONES RIS equipped with GIS functionality. DISCUSSION – FUTURE WORK • The activity maps along the coast (shown in Figs. 3 & 4) indicate the presence of elevated radioactivity levels near the sources of the submarine hydrothermal vents (at a depth of 2-3 m). A clear spatial correlation is apparent in the maps. • More data are currently under analysis to establish the full geochemical spread of naturally occurring radioactive substances around the hydrothermal vents in deeper waters. • An important aspect is to track the diffusion and transport of these radioisotopes away from the sources and establish the baseline activity at the coastal interface • The high-resolution results serve as validation for the mobile instruments γ-Sniffers • (near-)Real-time information collected with the RAMONES instruments will be updated on the RIS REFERENCES [1] RAMONES website, https://www.ramones-project.eu [2] P. Krassakis, et al., Geomatics 2, 297 (2022), doi: 10.3390/geomatics2030017 RAMONES receives funding from European Union under Horizon 2020 FET Proactive Programme via grant agreement No. 101017808 Pavlos Krassakis1, Konstantina Pyrgaki1,2, Theo J. Mertzimekis2, Konstantinos Nikolopoulos3, Stavroula Kazana2, Eleni Petra2 Figure 3 / 226Ra spatial distribution at Paleochori (Southern Milos) sampling areas. Basemap source: ESRI Figure 4 / 40K spatial distribution at Paleochori (Southern Milos) sampling areas. Basemap source: ESRI RESULTS – GEOCHEMICAL RISK • Two of the produced maps shown below in Fig. 3 and 4 represent the spatial distributions of 226Ra and 40K, respectively. These natural radioisotopes serve often as tracers for understanding the geochemical dynamics in the marine environment. • The GIS platform [2] will produce heat maps, represented by a five-color code (no risk / normal / low risk / high risk / eminent risk) to provide clear information to interested stakeholders. In the final processing stage, the results will be prepared as web layers on ArcGIS Online, which is a cloud- based Software as a Service (SaaS) Web GIS platform that allows access from any internet-connected device. Figure 2 / A γ-Sniffer | poster |
CancellationTools: All-in-One Software to Collect and Analyse Multi-Target Visual Search Data Edwin S. Dalmaijera, Stefan van der Stigchelb, Tanja C.W. Nijboerb,c, Tim H.W. Cornelissenb, & Masud Husaina,d a Experimental Psychology, University of Oxford, b Helmholtz Institute, Utrecht University, c Rudolf Magnus Institute & Rehabilitation Centre De Hoogstraat, University Medical Centre Utrecht, d Nuffield Dept. of Clinical Neuroscience, University of Oxford open source high-quality data visualisation complete and automated analysis run all cancellation tasks download Customizable test properties: - input type (touch screen or mouse) - cancellation marking visibility - target and background colour - target and distractor properties Or scan your own task Scan the QR code, or visit our website: www.CancellationTools.org edwin.dalmaijer@psy.ox.ac.uk CancellationTools is released under the GNU General Public License, ensuring it will always be free and open to everyone. The source code is available from GitHub: https://github.com/esdalmaijer/CancellationTools partners and sponsors @esdalmaijer CancellationTools was developed at the University of Oxford, in collaboration with Utrecht University. It is supported through the Individualised Diagnostics & Rehabilitation of Attention Disorders (INDIREA) project, sponsored by the European Commission. For more information, please visit www.indirea.eu. neglect centre of cancellation omissions per half working memory immediate revisits delayed revisits search organisation inter-cancellation distance inter-cancellation angle path intersection rate best R performance inter-cancellation time search speed time-on-task Q score Analyse individual or group data with the click of a button. The fully automated process calculates almost every known index of cancellation performance (summarized below). The outcome is stored in an A4-sized PDF (useful for clinical testing) and a machine-readable text file (directly importable into spreadsheet editors, SPSS, or a programming language). Search organisation can be indexed by the standardised angle and the best R (correlation between horizontal/vertical position of a cancelled target and its cancellation rank number). Heatmap averages provide a visualisation of biases of spatial attention in a sample. Plot intensities are scaled to the theoretical task maximum, and comparable across individuals. healthy (N = 10) neglect (N = 10) cancellations omissions A cancellation path gives a full account of a patient's search behaviour. A superimposed heatplot (cancellations) reveals biases of spatial attention. best R = 0.88 std. angle = 1.00 std. distance = 1.00 M distance = 100 px best R = 0.88 std. angle = 1.00 std. distance = 1.00 M distance = 300 px We collected and devised indices that are independent of task properties, to allow for performance comparisons across tasks. supported platforms Currently, a standalone version is available for Windows, and a version for Android is on its way. We are also planning on creating versions for Mac OS X and Linux. If you can't wait for those, it is perfectly possible to run the CancellationTools code from source using Python. Additionally, you can run tasks from our website, www.cancellationtools.org, although you will still need a standalone version to analyse the data. Cancellation tests require participants to search for and cross out targets (circles with an opening on top, in the example below), while ignoring distractor stimuli. | poster |
Make your list, check it twice ✦ Erin Clary, Digital Research Alliance of Canada ✦ Beth Knazook, Digital Repository of Ireland ✦ Mikala Narlock, Data Curation Network Curatorial preservation checklist for repositories Introduction Generalist data repositories that accept a variety of dataset submissions will require comprehensive information about a dataset's creation, relevance, and long-term value to support informed preservation decisions. To enable structured and documented conversations between preservationists, depositors, and data curators, we have developed and refined a checklist to aid long-term preservation decisions. V2 published: doi.org/10.5281/zenodo.11371489 Checklist How to Use it Contact info Erin.Clary@alliancecan.ca b.knazook@ria.ie mnarlock@umn.edu iPRES 2024 Section 1: Preservation Intent Section 2: Ease of Preservation Researcher intent Cost Relevance to mission Rights and restrictions Value to communities Context: documentation Uniqueness Content: file formats Each ‘yes’ answer builds a more robust rationale for preservation. →There are no fixed number of ‘yes’ answers that make the decision.← At the end of the checklist, the curator makes a preservation recommendation: ❏ Yes / No These decisions can easily be reviewed in the future. Try it out! - What worked well? - What is missing? - Let us know what you think: forms.gle/5XUhRykdWCzj3Cqe7 | poster |
Extensible and Community-Driven Thermodynamics, Transport, and Chemical Kinetics Modeling with Cantera: Expanding to Diverse Scientific Domains COLORADO SCHOOL OF Jongyoon Bae, Bang-Shiuh Chen, Steven DeCaluwe, Franklin Goldsmith, China Hagström, Gregory Jackson, Robert Kee, Gandhali Kogekar, Daniel Korff, Kyle Niemeyer, Sun Su, Raymond Speth, Anthony Walker, Bryan Weber, Richard West, Chao Xu, and Xinyu Zhao - Cantera objects/classes represent: - Phases of matter (solids, liquids, gases, interfaces) - Functions to calculate properties and rates - Solvers for chemical equilibrium, time-dependent 0-D systems (reactor networks), and steady-state 1-D reacting systems (flames) - Core library written in C++ with interfaces for user applications available in Python, C++, MATLAB, C, and Fortran 90 - Cantera’s object-oriented architecture enables efficient development of new models This work is supported by the National Science Foundation under Grant Nos. 1931584, 1931391, 1931539, 1931592, 1931397, and 1931389. New developments with NSF funding - YAML-based input file format - Provides easy access to user-defined data fields - YAML files can be generated from dynamically- generated/modified Cantera objects (serialization) - Enables efficient interoperability with other tools - Extensibility of Cantera C++ models using Python classes - Allows users to extend existing C++ models with Python code - Enables rapid prototyping and easy distribution of new scientific models - New reaction rate models - Blowers-Masel parameterization, which captures sensitivity to enthalpy of reaction - Plasma reactions with distinct electron and gas temperatures - New thermodynamic models: - Peng-Robinson equation of state for real gases - Plasma phases including calculation of the electron energy distribution function - Non-ideal surface phases with coverage-dependent thermo - Adaptive preconditioning - Accelerate integration of kinetic models with 1000s of species - New user interfaces being developed for Julia and .NET/C# - Implemented using source code generation to simplify maintenance of repetitive wrapper code - Simpler installation options - pip package for the Cantera Python module - Workshops & community engagement - Established Cantera Scientific Advisory Board with representatives from academia, industry, and government - National Combustion Meeting Workshop (May 2021, virtual) - Combustion Symposium Workshop (July 2022, Vancouver) - ACS National Meeting Workshop (August 2022, Chicago) Cantera is an open-source suite of tools for solving problems involving chemical kinetics, thermodynamics, and transport processes. Cantera Input File (YAML) Computational Model species: - name: CH3 composition: {C: 1, H: 3} thermo: model: NASA7 temperature-ranges: [300.0, 1000.0, 5000.0] data: - [1.051551, 0.0259919, 2.380054e-06, ...] - [7.702698, 0.0160442, -1.9609569e-08, ...] transport: ... - name: CH2O composition: {C: 1, H: 2, O: 1} ... reactions: - equation: H + CH3 (+M) <=> CH4 (+M) type: falloff low-P-rate-constant: {A: 2.6e+33, b: -4.8, Ea: 2440} high-P-rate-constant: {A: 1.4e+16, b: -0.5, Ea: 536} Troe: {A: 0.783, T3: 74.0, T1: 2941.0, T2: 6964.0} efficiencies: {H2: 2.0, H2O: 6.0, ...} - equation: O + CH3 <=> H + CH2O # Reaction 10 rate-constant: {A: 5.06e+13, b: 0.0, Ea: 0.0} - equation: H + CH2CO <=> CH3 + CO # Reaction 81 rate-constant: {A: 1.13e+13, b: 0.0, Ea: 3428.0} ... phases: - name: flamegas thermo: ideal-gas kinetics: gas transport: mixture-averaged Goals of this project Extend Cantera’s capabilities - Support scientific discovery and technology development in energy storage & conversion, chemical processing, and atmospheric chemistry Expand Cantera’s user base - Outreach to critical fields including electrochemistry, heterogeneous catalysis, and atmospheric chemistry Broaden participation in the software’s development and management - Improve Cantera’s sustainability and usability SUNDIALS (ODE solver) Eigen (linear algebra) libyaml-cpp (in | poster |
Supported by: Paper citation: Payne, L.J., Todeschini, T.C., Wu, Y., Perry, B.J., Ronson, C.W., Fineran, P.C., Nobrega, F.L., Jackson, S.A. (2021) Identification and classification of antiviral defence systems in bacteria and archaea with PADLOC reveals new system types. Nucleic Acids Research, 49, 10868-10878. • We have developed PADLOC, a tool to identify many widespread defence systems, including recently discovered systems. • Using PADLOC, we have discovered additional proteins frequently associated with several known defence systems and classified these into new system subtypes. • We have identified several phages that are inhibited by these new defence systems. • PADLOC is available as a standalone package (https://github.com/padlocbio/ padloc) and as a webserver (https://padloc.otago.ac.nz), which allow analysis of user-supplied genomes. Summary • When expressed heterologously in E. coli, the new systems limit phage infection. • Several phages exhibited reduced ability to form plaques on bacterial lawns (efficiency of plaquing; EOP) and collapse of liquid culture was prevented at a multiplicity of infection (MOI) below 0.1. New systems provide defence against phage infection Clone defence system Transform into E. coli Infect with phage Measure infection efficency Control Zorya III Hachiman II Lamassu II EOP relative to control (%) Control Zorya III Hachiman II Lamassu II Phage T1 T3 T4 T7 LambdaVir PVP-SE1 0 20 40 60 80 100 120 *** * *** ** ** * ** * ** ********* 0 300 600 900 0.0 0.5 1.0 1.5 2.0 2.5 MOI = 0 OD600 0 300 600 900 MOI = 0.01 Time (min) 0 300 600 900 MOI = 0.1 strong weak Identify loci with at least two genes of the same system Cluster genes in the neighbourhood of defence loci Assess the frequency of association Genomes 1 2 3 n Select novel variants with frequently associated genes 36,395 loci 41,470 genomes 73,063 clusters 225,898 genes 6 variants + 1 new system 730,430 associations ThsA ThsB HamA HamB PtuA PtuB ZorA1 ZorB1 LmuA LmuB ThsC HamC LmuC DruE2 DruF2 PtuC ZorG ZorF DruL Canonical Associated Association frequency 0.5 0.75 1.0 • By analysing these associations, we discovered several new system subtypes and a novel system comprising a Helicase, Methylase and ATPase. • To demonstrate how PADLOC can be used to address biological questions, we systematically identified proteins frequently associated with known systems. Identification and classification of new defence systems • Shown is a subset of all defence systems identified with PADLOC in ~200,000 RefSeq genomes. • More than 100 types of defence systems can currently be identified using PADLOC, including CRISPR-Cas, Abi, and many recently discovered systems. 0 2.5 5 7.5 >10 Average percentage of genomes in each species encoding a system Bacteria Archaea 10 1 1 1 1 6 4 4 6 1 2 1 2 2 3 2 1 6 1 15 5 1 12 3 8 2 16 5 3 14 5 9 3 5 5 3 3 5 11 2 2 3 1 2 12 3 1 4 1 1 7 7 1 1 12 14 1 1 4 21 17 9 17 34 13 3 3 9 1 2 1 21 8 2 4 2 1 22 7 4 5 1 2 5 5 16 5 2 7 5 5 20 8 1 2 4 6 4 1 1 13 2 1 1 1 2 15 3 2 2 8 5 24 1 6 3 15 6 10 3 1 2 2 3 3 1 8 1 31 1 8 1 1 13 13 13 3 8 3 19 2 3 9 7 1 2 1 2 17 7 6 4 1 1 13 3 3 11 7 2 7 4 3 2 4 5 3 36 5 14 14 8 8 3 1 2 1 1 1 1 16 4 1 4 2 5 1 3 4 3 8 10 1 8 4 3 1 1 16 7 1 5 3 10 6 7 12 9 13 1 1 13 1 2 2 2 16 11 11 5 2 6 9 4 36 20 15 2 9 3 2 1 16 6 3 3 3 12 1 5 6 9 3 6 3 22 22 25 1 1 9 5 5 10 1 5 37 5 3 5 1 6 12 4 5 4 32 4 11 1 4 7 15 29 38 17 4 4 9 10 12 4 6 59 19 2 1 13 6 4 17 12 1 12 12 6 6 12 12 12 11 5 3 2 3 10 12 12 6 3 15 9 21 11 7 3 4 1 1 1 3 1 20 7 1 3 4 3 1 16 1 6 3 1 8 1 1 5 3 11 4 2 2 6 9 2 3 1 4 4 3 11 5 3 5 12 10 3 6 2 13 18 1 3 6 18 14 8 2 2 2 8 2 2 12 4 4 Thermoproteota Thermoplasmatota Methanobacteriota Halobacteriota Verrucomicrobiota_A Verrucomicrobiota Thermotogota Synergistota Spirochaetota Proteobacteria Planctomycetota Patescibacteria Nitrospirota Myxococcota Marinisomatota Fusobacteriota Firmicutes_F Firmicutes_E Firmicutes_C Firmicutes_B Firmicutes_A Firmicutes Fibrobacterota Desulfobacterota Deinococcota Deferr | poster |
Searching for Superhump-like variations on Cata- clysmic Variables using VVV and VVVx data Lagos, Denisse1 & Barría, Daniela. Bachelor’s Degree in Astronomy, Universidad Central, Coquimbo, Chile 1denisse.lagos@alumnos.ucentral.cl Abstract At this work, we explore the presence of Superhumps(SHs) and SHs-like variations at infrared (IR) wavelengths in cataclysmic variable stars (CVs), specifically in Dwarf Nova and Classical Nova types. SHs – periodic photometric oscillations that are slightly shifted from the orbital period (Po) – are usually seen during superoutbursts and are linked to instabilities in close binary systems’s accretion disks. Previous studies have mainly studied SHs in optical bands, so this study focuses on detecting them in the IR. Using light curves from the VVV/x project and the VIVA catalogue, 140 CV systems were identified, and 85 of them were analyzed so far, for frequency detection via periodogram analysis using Period04. Although significant frequencies were detected in the periodograms, none of them corresponds strictly with a SH period. However, at some systems, we have found SHs-like variations. Further studies using the PDM technique will be conducted in the near future. Introduction CVs are a type of close binary systems, where a white dwarf (WD-primary star) pulls ma- terial from a main-sequence companion (sec- ondary star) through an accretion disk (Fig.1 and Fig.2). This, driven by viscosity, loss orbital energy as gas spirals toward the WD, emitting radiation that contributes to the total luminos- ity of the system (Warner, 1995). Light curves reveal changes in a star’s brightness over time and for binary systems they often show dips due to the orbital motion. Additional photometric variabilities, known as superhumps (SHs), might appear in the light curves of CVs as a result of instabilities in the accretion disk (Bruch, et al. 2022, 2023). SHs come in two types: positive SHs, with a period slightly longer than the Po, and negative SHs, with a slightly shorter period. We used 85 CV light curves retrieved from the VVV Survey (Minniti et al. 2009) database at band Ks, to perform a time series analysis us- ing Period04a.To our knowledge, SHs have not been investigated in the IR and this is the main motivation of this work. awww.period04.net Data Analysis We used the VIVA catalogue (Ferreira Lopes et al. 2020) to select 140 CVs (Dwarf Nova and Nova systems) which have been previously studied at visible wavelengths. Ks band light curves for these targets, were downloaded from the VSA-VISTA Science Archivea. A time series analysis was carried out using the software Pe- riod04 in order to identify significant frequencies via periodograms. ahttp://vsa.roe.ac.uk/ Figures Fig.1: An schematic view of a CV system. Fig.2: An accretion disk illustration. Results System ID515472646464 The VVV/DR5 Ks light curve of this CV shows magni- tude fluctuations between 13.5 and 14.1, reflecting typi- cal brightness variations for such systems (see right up- per panel). In the periodogram (bottom panel), a signif- icant peak appears at a frequency of ∼7.1 d−1, with a SNR exceeding 4σ. This periodicity corresponds to the Po according to previous analysis (Ferreira Lopes et al. 2020). The table (right lower panel) list the significant frequencies, amplitudes and SNR found in Period04. System ID515600867128 This CV displays a Ks light curve with magnitude variations between 10.0 and 12.5, reflecting brightness changes typical for these systems. In the periodogram, a significant peak appears at a frequency of ∼1 d−1, with a SNR exceeding 4σ. This finding is slightly higher than the Po reported in the VIVA catalogue and thus we consider that this frequency corresponds to a SH-like variation. System ID515845503587 In this system, the light curve shows magnitude vari- ability between 11.5 and 14.5, reflecting the system’s in- trinsic orbital motion. The periodogram displays a sig- nificant peak at a frequency near 0.0015 d−1 | poster |
ULRI As a leading independent safety science research organization with global reach, we explore both the benefits and risks of today’s technologies and pursue answers to socially relevant questions related to public safety. ULSE As a global, nonprofit standards development organization, we collaborate with experts around the world and translate scientific discoveries into standards and policies that have the power to make a systemic impact on public safety. Overview of current research locations On the development of a competency-based approach to research safety training Process Educational Influence Paulo Freire (1921 – 1997) was an influential educator and philosopher. Freire’s ideas challenged hierarchal education models, placing the student and teacher as equals rather than passive recipients. Freire’s concept of critical dialog emphasized the role of conversation in learner engagement, individual application, and empowerment. Freire’s theories help to find common ground and are easily adapted in health and safety management, independent of prior experience or existing knowledge. Further reading: Harris DB, Roter DL. Profound Love and Dialogue: Paulo Freire and Liberation Education. Health Lit Res Pract. 2024 Jul;8(3): e118-e120. doi: 10.3928/24748307-20240613-02. Epub 2024 Jul 5. PMID: 38979815; PMCID: PMC11230641. Outcomes • The delivery time is two to three hours, delivered over three to four sessions. • Standardized PPE, supplies, and services can be ordered directly through HSE, thus eliminating approval barriers and payment issues. • Teaching sessions were aligned with shipping large packages of safety supplies to each institute to help get everyone started. Evaluation • Administration of a single written knowledge test based on objectives • Observation of lab practices and peer-to-peer interaction. • Participant feedback, both formal and informal Evolution Transform classroom content into a multimedia course. Supplement online content with periodic in-service training. Remain focused on competencies in the lab and engagement in the hazard and risk assessment process. Presented at Working on Safety BUILDING A RESILIENT FUTURE Towards sustainable safety in a rapidly changing world 22 – 25 September 2024, Dresden, Germany ©2024 Underwriters Laboratories Inc. ©2024 ULSE Inc. Engage Scientists • Develop a conversational style focusing on processes, concepts, and critical facts. • Seek consensus on the role of safety in their work and discuss stop work authority. • Generate a syllabus of standard and specialized knowledge tied to course objectives. • Observe interactions of randomly assembled groups of participants during small-group exercises. Identify leaders. Define Expectations Four pillars to build upon, stated in behavioral terms, are woven into the culture and practices of each institute. Module I | Assessing Hazards & Determining Risks Goal: to develop common standards of care for laboratory safety at ULRI and engage in continuous improvement to protect individuals, one another, public health & the environment. After you participate in today’s program, you should be able to: • Outline the basic elements of risk management. • Define the essential elements in a hazard and risk assessment. • Identify so-called Y Factors that can exacerbate or mitigate the inherent hazards of a hazardous chemical in an experiment. • List the critical information found on a chemical container. • Name where you can find additional information when assessing potential hazards. • Describe the “Hierarchy of Controls” and the three most essential elements in research safety. • Given updated Safety Data Sheets and other suggested references, work in small groups to conduct a basic hazard and risk assessment for different classes of chemicals. Present and discuss your work with your colleagues to discuss. Module II | Controlling Outcomes & Preparing for Emergencies After you participate in today’s program, you should be able to: • List the | poster |
Introduction During the Covid-19 epidemic, one of the biggest common recurring global issues has been the ability to perform mass testing of populations, addressing both the dual needs of public health reporting (statistical) and private citizen privacy protection. Materials and methods Research was conducted to determine current methods of reporting and limitations of these current methods, application of new privacy enhancing technologies and self sovereign identity impact of self reporting and means of both authenticating self reporting and binding an identity to tests and subjects in a secure and privacy preserving manner. Results Conclusions Current centralized reporting addresses public health reporting. However, no easy way for citizen to share results with a third party and control who sees these results. Use of ”self sovereign” identity can enable a citizen to selectively share information to a third party. New forms of zero knowledge proofs that work with blockchains – ZKSnarks, can be used to both provide privacy protection and home testing validation. Stephen Holmes, PGR FEPS Computer Science, Surrey University s.a.holmes@surrey.ac.uk Citizen reporting and privacy protection in a post Covid-19 world Acknowledgments Thank you to Simons institute at UC Berkeley for enabling me to participate in Lattice cryptography bootcamp where I was introduced to the full capabilities of lattice-based cryptography. Zero Knowledge Proof conference – At home edition (5 weeks in May 2020) to enable participation in Zero Knowledge Proofs standardization activities. My PhD supervisor: Kaitai Liang, who has encouraged me to investigate what was a detour from my current research, applying this to the Covid testing challenges. Literature cited Short Non-interactive Zero-Knowledge Proofs, Jens Groth, University College London https://www.iacr.org/archive/asiacrypt2010/6477343/6477343.pdf Shafi Goldwasser, Silvio Micali, and Charles Rackoff. The knowledge complexity of interactive proofs. SIAM Journal of Computing, 18(1):186–208, 1989. Bitcoin: A Peer-to-Peer Electronic Cash System, Satoshi Nakamoto ZoKrates - Scalable Privacy-Preserving Off-Chain Computations July 2018 DOI: 10.1109/Cybermatics_2018.2018.00199 Distributed Auditing Proofs of Liabilities, Konstantinos Chalkias, 2020, https://eprint.iacr.org/2020/468.pdf , Further information The project is currently under active development with a view to commercialise this research. Currently in discussion to include this with other Covid reporting protocols and applications. Today Future Traditional health care systems with health care professionals involvement Data is recorded on blockchain/ or Distributed ledger. Result is off-chain so can be deleted Reporting not optimized for speed Multiple data stores to interrogate to get statistical snapshot Blockchain enables authorities to automatically collect statistical data Identity is explicit government issued identity Identities are pseudo anonymous Can be part of Self Sovereign identity. Citizen needs to request certificate from health care professionals. Citizen generates proof on request and shares proof with third party. Can specify expiry date and identity of receiving third party. Overview The starting point for this research was an investigation of how privacy may be enhanced through the application of zero knowledge proofs to address the issue of how to empower a citizen to be in control of their Covid19 test results. Given the ongoing research on immunity passports and the development of home testing kits, the biggest problem appeared to be – How do you prove that you took a test to a third party without compromising an individual’s privacy? What became apparent in the first stage of Investigation was that the home testing cassettes were designed to be mass produced an anonymous. However, without the involvement of a medical health professional there is no easy way to prove you took the test and prove what the results were to a thir | poster |
Development of a New Algorithm and Scoring Metric for the Evaluation of Scientific Conference Impact LAUDANO, JBA, HONG, SA, WEI, GA, SKIRBE, PA, MATHEIS, RB AMEDMEME LLC, NEW YORK, NY BCELGENE CORPORATION, SUMMIT, NJ The Authors would like to thank Mr. Won Kim, Mr. Siddhartha Naithani and Mr. Jonathan Kendall for the expert assistance in data collection and interpretation. We would also like thank Mr. Jeff DeGeorgia for his creative direction in the development of this poster. 1. Higgins C, Horner A, Wassef-Birosik L, D’Irio S. Integrating Measures of Journal Impact Provides dditional &nsihts in QcientiÚc 4iterature "ap nalÐses. Jresented at the ȀȂth nnual Meetin of &QMJJȫ MaÐ ȀȶȂȫ ȁǿȀȆȫ ;ational %arworȡ M. Joster ȥȈ. ȁ. "arÚeld . Vhe %istorÐ and Meanin of the Journal &¥pact !actor. JM. ȁǿǿȅȫȁȈȄȲȀȳȠȈǿȶȈȂ. Ȃ. okku Mȡ Qridharan 2ȡ MaeeÍ J. Manuscript Qtrenth !inder VoolȠ n id in eter¥inin Jotential Journal cceptance. Jresented at the ȀȀth nnual Meetin of &QMJJȫ pril ȁȆȶȁȈȡ ȁǿȀȄȫ rlintonȡ b. Joster ȥȀȈ. 4. %irsch J. n index to ·uantifÐ an indiÍidualɀs scientiÚc research output. Jroceedins of the ;ational cade¥Ð of Qciences of the Ynited Qtates of ¥erica. ȁǿǿȄȫȀǿȁȲȃȅȳȠȀȅȄȅȈȶȀȅȄȆȁ. Ȅ. Qan !rancisco eclaration on Mesearch ssess¥ent Ȳ@Mȳ. nnual Meetin of Vhe ¥erican QocietÐ for ell ioloÐ ȲQȳȡece¥wer Ȁȅȡ ȁǿȀȁȡ in Qan !ranciscoȡ . httpsȠȬȬsfdora.orȬ ȅ. Med¥e¥e atawase. JroprietarÐ datawase of puwlished ¥edical science. Ȇ. allawaÐ . Juwlishin elite turns aainst i¥pact factor. ;ature. ȁǿȀȅȫȄȂȄȠȁȀǿȵȁȀȀ. 8. Vi¥e to re¥odel the ournal i¥pact factor.Ȱditorialȱ.;ature.ȁǿȀȅȄȂȄȠȃȅȅ. Ȉ. Vhe uropean ssociation of Qcience ditors ȲQȳ Qtate¥ent on &nappropriate Yse of &¥pact !actors. MetrieÍed ȁǿȀȇȶǿȀȶȀȈ. Dr. Joseph B. Laudano, Dr. Saman Hong, Mr. George Wei and Mr. Paul Skirbe are employees of Medmeme LLC, New York, NY. Dr. Robert Matheis is an employee of Celgene Corporation, Summit, NJ. No animals were harmed in the production of this poster. Jresented at the ȁnd nnual Meetin of Vhe Medical ffairs Jrofessional QocietÐ ȲMJQȳ !ewruarÐ ȁȄȶȁȆȡ ȁǿȀȇȡ Mia¥i !loridaȡ YQ. Please address questions and requests for reprints to Dr. Joseph B. Laudano at J.Laudano@Medmeme.com QtudÐ !unded wÐ Med¥e¥e 44ȡ ;ew eorkȡ ;e. ACKNOWLEDGEMENTS REFERENCES AUTHOR DISCLOSURE CHALLENGE/PROBLEM • Selecting the best and most appropriate scientific conference for the submission of research continues to be challenging for Medical Affairs Professionals (MAPs). While useful Scientometrics for the submission of manuscripts to journals are well established, there currently are no formal metrics for the selection of scientific conferences. • Creation of a scientific conference impact assessment tool has the potential to heighten impact of dissemination of evidence in scientific medical forums • Traditionally, we assume that conferences with the highest attendance and the highest volume of poster presentations within a selected field are those held in higher esteem for abstract submission, potentially having more “weight” or “reach”.1 • For journal selection, MAPs typically make their decisions using a number of parameters: • Impact metrics (Impact Factor, Eigenfactor, SCImago Journal Rank Factor, etc.) are well established citation-based indicators of journal impact.2 • Targeting tools for journals focusing on several different Article- Level Metrics (ALMs) may also be used as a predictor for manuscript acceptance.3 • Author metrics which measure a scientist’s productivity and citation impact (h-index) are also generally employed for study/author selection and the calibre of journals.4 • Based on an unmet need for relevant, timely and accurate metrics for the selection of scientific conferences and a “call” for a shift toward assessment of journal impact based on up-to-date ALMs vs. publication metrics (citations)5, we decided to develop a new algorithm and ranking method for the evaluation of scientific conference i | poster |
Simulating Protoplanetary Disk Ices How to observe ices in disks. Absorption features in the continuum from the central star and warm inner disk. Only seen in edge-on disks. Absorption features in the continuum from a star behind the disk. Albedo features in scattered light from the disk surface. Emission features in the far-IR. Nick Ballering1, Ilse Cleeves1, and Dana Anderson2 1University of Virginia, 2Carnegie Earth and Planets Laboratory Why simulate ice features? Ices are distributed heterogeneously throughout a disk, and ice observations cannot uniformly probe all regions of a disk. Forward models can connect observable features to the underlying distribution of disk ices. Methodology Use a gas-grain chemical evolution model to derive the abundance distributions of H2O, CO, CO2, CH3OH, CH4, and NH3 ices in a disk. Group model cells into “zones” of similar ice composition using a k-means algorithm, then compute the opacity for each zone. Use the radiative transfer code RADMC-3D to simulate ice features. The vertical distribution of ices Spatially mapping disk ice features is possible with JWST IFUs. Initial chemical abundances and evolution CO2 ice shows variation with time. CH3OH ice discriminates between “inheritance” and “reset” chemistry. Acknowledgements We gratefully acknowledge support from NSF award AST #2205698 and from the Virginia Initiative for Cosmic Origins. Scan to read the full paper Ice features vs. disk inclination H2O seen at 75-90o. CO2 and CH3OH are more prominent at higher inclinations. Scattered light features Ices features are present in the outer disk. | poster |
A putative condensin loading factor that controls yeast chromosome III architecture Abstract Manikarna Dinda1, Ryan D. Fine1, Mingguang Li1,2, and Jeffrey S. Smith1 1Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA 22908. 2Department of Laboratory Medicine, Jilin Medical University, 132013, China. Condensin plays an important and evolutionarily conserved role in mitotic chromosome condensation, three-dimensional genome organization and regulation of gene expression. Condensin is a multi-subunit complex that has natural affinity for the promoters of highly transcribed genes, and also associates with specific transcription factors. However, a general mechanism for functional loading of the complex onto chromatin remains elusive. Our lab previously demonstrated that in haploid MATa yeast cells, condensin and Sir2 (a histone deacetylase) both associate with the recombination enhancer (RE), a cis-acting element on chromosome III that directs donor preference of mating-type switching. Here, Sir2 locally regulates transcription of a small gene called RDT1, while condensin contributes to the 3-dimensional organization of chromosome III, as well as donor preference, indicating that the RDT1 promoter region acts as a locus control region (Li et al., 2019). We have now further characterized the mechanism of condensin recruitment to the RDT1 promoter LCR, and uncovered a critical role for a non-meiotic version of the monopolin complex, known as cohibin (Lrs4 and Csm1 subunits), analogous to its known role in recruiting condensin to the rDNA locus. To test if cohibin functions more generally in condensin loading, or as a condensin accessory factor, we have performed ChIP-seq for genome-wide condensin binding sites in WT and lrs4∆ strains. Numerous Brn1 peaks (including RDT1 and the rDNA) were eliminated or significantly reduced by lrs4∆, consistent with the condensin loader hypothesis. Micro-C XL was then used to characterize the general effects of defective condensin recruitment on genomic conformation in a lrs4∆mutant, or when the Brn1 condensin subunit was depleted using an auxin-inducible degron system. Alterations were observed on multiple chromosomes, though the most severe changes occurred on chromosome III, which had significant negative effects on the efficiency of mating-type switching, as well as donor preference. We therefore hypothesize that cohibin (Lrs4/Csm1) is indeed a condensin loader at the RDT1 promoter region, where it establishes chromosome III conformation, potentially through a loop extrusion mechanism. Evidence for direct recruitment of condensin by the cohibin complex at other genomic sites and any possible role for cohibin in chromosome condensation are currently under investigation. Dr. Chongzhi Zang, University of Virginia Dr. Zhenjia Wang, University of Virginia Supported by NIH GM075240 and GM127394 Aim Establish whether Lrs4 is a condensin loader at RDT1 promoter region RDT1 promoter region HIS4 promoter region 6. lrs4 Δ reduces condensin binding at the RDT1 promoter region Condensin Sir2 RDT1 Mcm1 minimum 700bp RE Mcm1 ARS304 100bp HML HMR MAT RDT1 promoter region CEN Condensin 11. Hypothetical loop extrusion model after binding of condensin to the RDT1 promoter • Lrs4 is the condensin loader at RDT1 promoter region. • Condensin is recruited to the RDT1 promoter and regulates mating type switching by maintaining the chromosome conformation. • Presumably, condensin by loop extrusion is facilitating the interaction of HML with MAT to repair DNA breaks in MAT a cells. 12. Conclusion 5. Proposed model of condensin and Sir2 recuitment to the RDT1 promoter by Lrs4 and Mcm1 1. Mechanism of mating type switching in budding yeast 10. Condensin depletion leads to loss of interaction between MATa-HMLα, HMLα- HMRa in ChrIII during mating type switching 7. Lrs4 helps to recruit condensin at RDT1 promoter in MATa cells MAT a cells MAT ! cells 4. A putative | poster |
Why investigating social and geographic factors ? In France and the Netherlands, which might have been less affected by urban shrinkage, or in a less spectacular way, than the American Rust Belt or eastern Germany for example, urban shrinkage has been an emergent theme from the end of the 2000s (Wolff, 2017). Monitoring social and geographic conditions of growth and decline in cities Solène Le Borgne (M.A.), University of Amsterdam s.f.leborgne@uva.nl Research design • Mixed-methods approach: quantitative analysis (survey?), qualitative analysis (interviews) • Comparative approach: France & the Netherlands • Possible case studies: Nevers in France (34 000 inhabitants), and Terneuzen, Winschoten, Den Helder, Delfzijl, or the Achterhoek region (Gelderland) in the Netherlands Conceptual problems and methodology questions • Focus: are we looking at the social drivers, or the social impact of shrinkage, or both? • How to integrate a quantitative analysis to the qualitative approach, in order to answer the main research question? Comments? Suggestions? Write it down! Photos: Left: Nevers, location (Google Earth, screenshot) Right: Nevers (credits: Daniel Villafruela) Urban shrinkage in medium sized cities The decline of former industrial regions, and especially important cities, has been well documented. Less is known about the processes encountered by medium sized cities, sometimes located in rural regions. Yet, in France and the Netherlands, these are particularly affected by shrinkage (Guéraut, 2018). It is thus relevant to deepen our understanding of how shrinkage occurs, with which logics and outcomes, in this kind of space. The social dimension of shrinkage The topic has been tackled mainly by economic geographers and planners, with a focus on demography, policy making and governance. The social dimension of shrinkage – social drivers and social impact of the phenomenon – has been less analysed. Yet, this phenomenon does affect the social structure as a whole and the residents at the individual level. The social dimension, both as a factor and an outcome, needs to be better considered and analysed. How do the residents’ sociospatial ties influence their migration patterns in and out of shrinking cities? 1. What is the impact of life course events on the residents’ mobility? 2. How can one’s social ties be an incentive to stay or to leave? 3. How do place attachment and sense of belonging influence the residents’ migrations ? 4. What is the role of social and localized capital in the stay or leave decision? 5. Why coming back to the hometown after a period of outmigration? 6. What is the role of social capital in the successful installation of newcomers ? | poster |
CMS Experiment At the CMS experiment, a hierarchical set of algorithms, called the trigger system, processes and filters the incoming data stream. The CMS trigger system is structured in two stages: - Level 1 Trigger (L1 Trigger) implemented on custom-designed electronics, reduces the 40 MHz input to a 100 kHz rate. L1 Trigger algorithms are implemented on Field Programmable Gate Arrays (FPGAs) and have 3.2 μs to decide whether to pass an event to the next step. - High-Level Trigger (HLT) is a collision reconstruction software running on a computing farm. It scales the 100 kHz stream from the L1 Trigger rate to 1 kHz in 100 ms. The trigger system throws away 99.9975% of events (99.75% at the L1 Trigger). The Large Hadron Collider (LHC) at CERN operates at a rate of 40M events per second. This enables physicists to search for rare and new interactions. Due to technological limitations (e.g. storage constraints and readout electronics), the experiments at the LHC are required to reduce the amount of recorded data. The Princeton group at CMS is developing CICADA (Calorimeter Image Convolutional Anomaly Detection Algorithm). - CICADA is a fully autonomous AI algorithm that can process LHC event data in real-time - CICADA independently picks out topologies that are different from the majority of currently recorded events. - CICADA operates close to the rawest recorded data, i.e. calorimeter energy deposits. In this manner, CICADA has as little human bias as possible. CICADA leverages deep learning-based anomaly detection and methods for efficient neural network deployment in hardware. Anomaly Detection with Machine Learning Neutrino Experiments Elements: RAD Discoveries for Fundamental Physics Collaborators: Georgia Karagiori, Akshay Malige (Columbia University), Isabel Ojalvo, Pallabi Das, Adrian Pol (Princeton University) Anomaly detection is challenging when dealing with non-linear data relationships, especially in particle detectors. Deep learning, particularly Convolutional Neural Networks, excels at learning from raw energy deposits in this context by uncovering hierarchical features. This eliminates manual feature engineering and adapts to various input natures, making it ideal for image- based anomaly detection in calorimeter data, where calorimeter cells are treated as pixels representing energy deposits after projecting and unwrapping. The groups propose to utilize methods for efficient model deployment to meet computing constraints, i.e. quantization, pruning and knowledge distillation. - Quantization involves assigning the model’s weights and activations to a lower bit-width representation. - Pruning deals with the problem of the optimal removal of parameters deemed unimportant via some heuristic. - Knowledge distillation is a method of training a smaller network, called a student using soft labels generated by a larger network, called a teacher. Motivated by the use case, the Columbia and Princeton groups will propose novel methods for compression and deployment that are directly transferable to a broader physics community. Machine Learning on Highly Constrained Systems Student-Teacher Knowledge Distillation The teacher network condenses data into a latent space and then reconstructs back into the detector space using two NN. It then calculates the Mean Square Error Loss (MSE) between the output and input The student network uses a single dense layer Neural Network to calculate the MSE directly. Overall Project Goals: Advance detector real-time monitoring: Initially, we will instantiate AI algorithms to ``re-discover'' known physics processes or known detector issues, e.g. known dead channels, or noisy channels in the detector. The goal will be to demonstrate unsupervised learning capability in flagging detector abnormalities within the data. As part of this effort, we will also focus on physics/label-informed data dimensionality reduction. Goal 1. Goal 2. Goal 3. Expand physics capability of near-future experiments: N | poster |
A psychological approach to evidence‐based architectural design in domes7c spaces Colin Ellard1, Deltcho Valtchanov1, Thomas Seebohm1, Jus;n Perdue2, Sarah Susanka3 1University of Waterloo, Waterloo, Ontario Canada, 2Stantec Architecture, Toronto, 3Susanka Studios, Raleigh, NC Introduc7on In this experiment, we demonstrate a principled method for assessing the comfort, usability, and affec;ve proper;es of a series of domes;c spaces. We combine high‐level visualiza;on with immersive virtual reality, mo;on tracking and structured interviews to assess the quali;es of a variety of styles of domes;c spaces. This ini;al study is meant as a “proof of concept” for future studies in a variety of built seTngs ranging from ins;tu;onal and health care environments to the urban scale. Method 3d visualiza;ons of three exis;ng domes;c structures were constructed using 3d Studio Max and V‐ray. The structures were Frank Lloyd Wright’s Jacobs House, Sarah Susanka’s Milstein House, and a typical North American suburban house. Par;cipants were provided with immersive experiences of the models using head‐mounted displays, infrared mo;on tracking, and mobile compu;ng. The models were realized at actual size in a gymnasium. Par;cipants explored the spaces un;l they felt familiar with them, and then they were asked a series of ques;ons about their preferences for par;cular loca;ons. Figure 1. A screenshot of the Milstein House visualiza7on Results Par;cipants were asked about their overall preferences for certain aspects of each of the models. Results suggested that designers’ inten;ons were, to some extent, manifest in the opinions of par;cipants. For example, the Milstein House, which was designed to enhance both opportuni;es for socializing and privacy [1], appears to have met both of these objec;ves. Table 1. Mean responses of par7cipants to general ques7ons pertaining to affec7ve proper7es of the three VR models. Par7cipants were asked to rank each of the three models on a scale of 1‐5 for the parameters listed in the table. The final ques7on asked par7cipants how likely they would be to purchase each of the homes if they had the opportunity to do so. Using Ajanachara so]ware [2] the spa;al proper;es of the home designs were analyzed to determine such proper;es as isovist size (area of space observable from a given loca;on), and other higher order proper;es of spa;al shape. Analyses were converted to contour plots to visualize how spa;al proper;es varied between loca;ons in the space. The figure below shows an example of such a contour plot from the Jacobs House. Figure 2. Spa7al analysis of Jacobs House. Colour coding corresponds to size of visible region of space from each loca7on in the space. Light colours indicate large visible regions of space and dark colours indicate small visible regions of space. Figure 3. Par7cipants were asked: “If this were your house and you were having a party, where would you go to oversee Conclusions The findings described here, although very preliminary in nature suggest the viability of a method for assessing the affec;ve proper;es of architectural spaces using a combina;on of immersive virtual reality, mo;on tracking, and tradi;onal structured interview methods of experimental psychology. In future work, we hope to add to these findings by including measurements of physiological reac;ons during explora;on of such spaces, including eye movements, heart rate, skin conductance and EEG. References [1] Susanka, S. (1998). The not so big house: A blueprint for the way we really live. Taunton Press: Newton CT. [2] Wiener, J.M., Franz, G., Rossmanith N., Reichelt A., Mallot H.A., & Bulthoff H.H. (2007). Isovist analysis captures proper;es of space relevant for locomo;on and experience. Percep:on, 36(7), 1066‐1083. This work was supported by funding from the Social Sciences and Humani:es Research Council of Canada. The authors gratefully acknowledge the assistance of Gloria Sicuro. Ela Malkovsky, Hannah Masterman, Leanne Quig | poster |
Sentinel-3 SLSTR Cal/Val activities for sea surface temperature measurements I. Tomažić (1), A. O’Carroll(1), G. Corlett (2), J.F. Piolle(3), P. Dash(4) , C. Donlon(5), D. Smith(6), S. Dransfeld(7), T. Hewison(1), A. Burini(1), F. Montagner (1) , V. Santacesaria(1) (1)EUMETSAT, Darmstadt, Germany (2)The University of Leicester, Leicester, United Kingdom (3)IFREMER, Plouzane, France (4)NOAA affiliate, US (5)ESA/ESTEC, Noordwijk, The Netherlands (6)RAL Space, Rutherford Appleton Laboratory, Harwell Oxford, UK (7)ESA/ESRIN, Frascati, Italy Introduction Copernicus Sentinel-3 (S-3) satellite carries the Sea and Land Surface Temperature Radiometer (SLSTR) and is a follow on of AATSR instrument. It is employing along track dual view scanning and two on-board calibration targets to obtain improved Sea Surface Temperature (SST) measurement. The first satellite in the series (S-3A) was successfully launched in February 2016 and the next one (S-3B) was launched in April 2018 to complete the first operational Sentinel-3 mission constellation. The next S-3 mission constellation (consisting from S-3C and S-3D) will ensure SLSTR data continuation for Copernicus program at least up to 2030. Sentinel-3A: 16th Feb 2016 Sentinel-3B: 25th Apr 2018 Instrument monitoring Geolocation verification Radiometric intercomparison: SLSTR vs IASI SST is the main parameter obtained from SLSTR instrument and one of the key parameters in global climate monitoring. Therefore, there is a very stringent requirement on producing SST retrievals from SLSTR. Absolute accuracy should be better than 0.3 K and with a temporal stability of 0.1 K/decade. To enable and confirm such a stringent requirements, set of Cal/Val activities are implemented for Sentinel-3/SLSTR mission both on Level-1 and Level-2 products. The main one on Level-1 encompasses monitoring of geolocation accuracy and radiometric inter-comparisons of SLSTR infrared channels with Infrared Atmospheric Sounding Interferometer (IASI), while on Level-2 it covers SST bias characterisation by comparison with in situ measurements and inter-satellite and inter-algorithm comparisons against Level-4 SST analysis. SST Bias Characterisation: Inter-satellite and inter-algorithm comparisons • Satellite comparison with OSI-SAF and CMEMS products • Analysing individual algorithms and instrument characteristics • Global and regional routine analysis • Daily, monthly plots, maps, time-series, histograms, .... • METIS: http://metis.eumetsat.int/sst/ SST Bias Characterisation: Comparisons with in-situ measurements • Copernicus Coriolis in situ service: drifters on GTS, OceanSITES (Pirata, GTMBA, ...) , Argo GDAC, GTSPP • Routine and automatic collocations (felyx) of SLSTR L1/L2 over in situ measurements and ship mounted radiometers • OSI-SAF Federated Activity SLSTR MDB: drifters, Argos, moored, radiometers •Current status: NRT@OPE and NTC@REPRO with SL L1 IR channels •Upcoming changes: NTC@OPE and NTC@REPRO with SL L1 all channels •Results presented for cycle 30: 07.04.2018-04.05.2018 •Results based on newly implemented Bayesian cloudmask SST L3 analysis Acknowledgements We would like to acknowledge The European Commission Copernicus Programme; The European Space Agency; Scientists and Industry throughout Europe. Special thanks to EUMETSAT, ESA and MPC/ESL collegues and to EUMETSAT S3-OPIT team. References EUMETSAT Sentinel-3 Mission Performance Implementation Plan (EMPIP), 2016, Issue v1C, pp.100 Sentinel-3 Calibration and Validation Plan, 2014, Eumetsat/ESA, S3-PL-ESA-SY-0265, Issue 2, pp. 235. Donlon, et al, The Global Monitoring for Environment and Security (GMES) Sentinel-3 mission, RSE, 120 (2012) Radiometric intercomparisons of AATSR and IASI, 2013, C. Whyte, D. Moore, J. Remedios Detector temperatures for IR channels from Jan 2017 to May 2018. Small discontinuities occur due to the scheduled decontamination or following an anomaly. The vertical lines indicate the start and end of each decontamination cycle. • Geolo | poster |
Surviving Involuntary Displacement: Homeowners vs. Renters Michael Moreno, University of Illinois at Chicago Dr. Joseph K. Hoereth, Institute for Policy and Civic Engagement, University of Illinois at Chicago Introduction Findings Recommendations Methodology Purpose Conclusions • In the late 1950s there was an increase in Hispanic presence within the community of Chicago. The city accounts for about 803,476 Hispanics who reside within the city alone (2016 American Community survey). • There is an ongoing trend of residential displacement within Hispanic dominated communities, in part due to urban revitalization initiatives that ignore minorities who live in the neighborhood. • Gentrification contributes to the displacement of inhabitants in major Hispanic dominated Chicago communities such as the Lower West Side (Pilsen), South Lawndale (Little Village), Humboldt Park, and Brighton Park. • Hispanic population in Chicago is high, but the number of Hispanics who own homes remain low in the neighborhoods mentioned; most of these inhabitants are renters. • As a result of Pilsen’s gentrification process, its Latino population has fallen from 89% in 2000 to roughly 82% in 2010, while the White population has increased by about 28% (Anderson 2012). Little village & Humboldt Park have shown similar cases. • Homeownership cannot guarantee that a Hispanic household owner would not be displaced, but it can certainly be an effective buffer in slowing the progression of any potential displacement. • The Correlation between homeownership rates and the displacement occurrences are further explored. • Gentrification does not have to mean displacement—If circumstances are aligned correctly. • In low-income neighborhoods where a significant percentage of residents own their homes, gentrification can be a life changing event for some families; leading to wealth-building that can dramatically improve their economic mobility. • Hispanic home buyers are more than twice as likely (42.8%) to have an FHA loan than a conventional financing loan—meaning Hispanics have to pay more in insurance premiums. • At 66.3%, Hispanics have a higher labor force participation rate than non-Hispanic Whites (60.8%) or the U.S. overall average (60.9%). • In 2018, Hispanics achieved a net gain of 362,000 homeowners. This raised the Hispanic Homeownership rate from 46.2% in 2017 to 47.1% in 2018. Over the past decade, Hispanics have accounted for 62.7% of net U.S. homeownership gains. • Change the narrative around immigration by underscoring the economic case for immigration reform and support policies that strengthen economic stability for Latino families. • Increase and mandate the amount of inclusionary zoning areas which require that 10% of new or renovated residential apartment buildings be maintained as affordable housing. • Provide renters with the opportunity & financing to purchase their units; Preserve & expand public housing. • Establish a loan fund to help small business owners buy their buildings. • Establish community benefit agreements with investors in large projects to ensure that local residents benefit from the investments. The research on the effects of gentrification in Chicago neighborhoods has been driven by scholarly articles, Lower West Side (Pilsen) studies, South Lawndale (Little Village) studies, and Humboldt Park studies in order to fully analyze such discourse and propose possible policy recommendations. Analyze the impacts of gentrification in Chicago Hispanic neighborhoods and encourages a closer look at the gentrification issue when creating community development and planning policies. References Anderson, M. B., & Sternberg, C. (2013). “Non-white” gentrification in Chicago’s Bronzeville and Pilsen: Racial economy and the intra urban contingency of urban redevelopment. Urban Affairs Review, 49(3), 435- 467.doi:10.1177/1078087412465590 Betancur, J. (2011). Gentrification and community fabric in Chicago. Urban Studies, 48 (2), 383-406. doi: | poster |
Democratising and making sense out of heterogeneous scholarly content SciLake aims to leverage and extend Science Knowledge Graph (SKG) technologies as the foundation to establish the concept of the Scientific Lake: an ecosystem for creating, combining, and querying cross-domain and domain-specific SKGs. SciLake_project https://scilake.eu Smart impact-driven discovery service for ● Multi-perspective citation analysis ● Impact propagation to related research objects ● Publication field classification ● Research trend identification Scientific Lake as a service for ● Data acquisition ● Creation and interlinking of SKGs ● Data lake search and navigation Smart reproducibility assistant service for ● Research object recognition in textual data ● Research object link recommendation ● Text segmentation ● Citation-context assisted replication Research community pilots for service evaluation and showcase: ● Neuroscience ● Cancer ● Transportation ● Energy | poster |
−2 0 2 4 6 SNR Kp=196.5 km/s −2 0 2 4 6 SNR Kp=232.2 km/s −200−150−100−50 0 50 100 150 200 vrest [km/s] −50 0 50 100 150 200 250 300 350 Kp [km/s] −2 0 2 4 6 Signal-to-noise ratio ~ ¡ ¢ £ ¢ 10−6 10−5 10−4 10−3 Volume Mixing Ratio 10−8 10−6 10−4 10−2 100 102 Pressure [bar] H2O 1800 K 2200 K 2600 K 3000 K 10−6 10−5 10−4 Volume Mixing Ratio OH 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Wavelength [micron] 1.05 1.10 1.15 1.20 1.25 1.30 1.35 Transit depth [%] T=2700 K | poster |
High-resolution observations in T Cha: the ATCA and ALMA view Transitional protoplanetary disks are considered as the "missing link" between disks surrounding young stars and planetary systems. These disks show little or no excess emission at λ < 10 μm and a signi?icant excess at λ ≥ 10 μm. This lack of near-infrared excess was interpreted as a diagnostic of inner disk clearing possibly connected to the early stages of planet formation (e.g., Calvet et al. 2002). Dust clearing can be related with gaps or holes within the disks, which can be created by several mechanisms, such as a close companion, disk photoevaporation, or giant planet formation. Until recently, no planet had been detected around stars with transitional disks, but this has changed with the recent ?irst direct detection of a young accreting planet around LkCa 15 (Kraus & Ireland, 2012; Sallum et al. 2015) and a yet uncon?irmed substellar companion inside the gap of the transitional disk that surrounds T Chamaleontis (T Cha, hereafter; Huelamo et al. 2011). This opens a very interesting research line for studying in-situ formation of planets in transitional disks, being a unique opportunity to capture a key moment of on-going planetary formation. I. de Gregorio-Monsalvo1, N.Huelamo2, M. Ireland3,4, C. Pinte5, E. Macias6, P. Tuthill3, H. Bouy2, S. Lacour7, A. Kraus8 (1) ESO-ALMA (Chile), (2) LAEX-Astrobiology Center (INTA-CSIC) (Spain), (3) Macquarie U. (Australia), (4) Australian Astronomical Observatory (Australia), (5) UMI-FCA, CNRS/INSU, France , (6) IAA-CSIC (Spain), (7) Observatoire de Paris (France), (8) Hawaii U. (USA) REFERENCES: Calvet et al. 2002, ApJ, 568, 1008 Cieza et al. 2011, ApJL, 471, L25 De Gregorio-Monsalvo et al. 2013, A&A, 557, 133 Dullemond & Dominik, 2005, A&A, 434, 971 Huelamo et al. 2011, A&A, 528, L7 Huelamo et al. 2015, A&A, 575, L5 Kraus & Ireland, 2012, ApJ, 742, L5 Sallum et al. 2015, Nature 527, 324 Motivation Fig 2. ATCA map at 7 mm. The spatial resolution is 0.2”x 0.2“ The case of T Chamaleontis: T Cha is a young (~7 Myr) nearby (108 pc) T Tauri star with a Spectral Energy Distribution (SED) typical of a transitional disk. Huelamo et al. (2011) reported the presence of a substellar companion candidate within its gap (T Cha b). T Cha is surrounded by an outer disk whose main properties have been inferred from the modeling of its spectral energy distribution (Cieza et al. 2011). Those models are highly degenerate and can ?it the SED equally well either with a very compact (few AUs) outer disk or much wider tenuous disk with a very steep surface density pro?ile. To shed light on the peculiar disk properties of T Cha, we performed high angular resolution observations in the submillimeter, millimeter, and in the centimeter regimes. Unveiling the outer disk properties using ALMA High spatial resolution and high sensitivity ALMA observations in continuum and in CO(3-2) at 850 μm show T Cha is surrounded by a compact dusty disk and a three times larger gaseous disk (see Fig 1). Using the CO(3−2) image we derive an outer radius of the gaseous disk of 230 AU, an inclination of 67±5 degrees and a position angle of PA=113±6 degrees. The gas emission is in Keplerian rotation, and the estimated dynamical mass of the central object is 1.5±0.2 Msun, in good agreement with previous estimations based on evolutionary tracks. The dusty disk is resolved at 850 μm and it shows a similar inclination and P.A. to the gaseous disk. The continuum intensity pro?ile displays two emission bumps separated by 40 AU, suggesting for the ?irst time the presence of an inner dust gap as predicted by SED modeling, and an outer radius of ~80 AU. These data allow us to rule out both the very small and large Rout families predicted by SED models (Huelamo et al. 2015). Comparison with radiative transfer models We used the radiative transfer code MCFOST with a tapered exponential edge in the surface density distribution for reproducing simultaneously the gas and the dust | poster |
Expression Patterns in the Developing Zebrafish of Two Paralogs of Activating Transcription Factor 5 (atf5a and atf5b) Roberto Rodríguez-Morales1, Viveca Vélez-Negrón1, Aranza Torrado-Tapias1, Gaurav Varshney2 and Martine Behra1 1. Department of Anatomy and Neurobiology, University of Puerto Rico, Medical Sciences Campus , San Juan, PR 2. Oklahoma Medical Research Foundation (OMRF), Oklahoma City, USA The Activating Transcription Factor 5 (ATF5) is a basic Zipper (bZIP) transcription factor (TF) with a proposed stress-protective, anti-apoptotic and oncogenic role. In Atf5 KO-mice, olfactory sensory neurons (OSNs) are immature and instable, and the olfactory bulb (OB) to where they project axons, is smaller. In the ventricular zone (VZ), a neurogenic brain region, Atf5 is strongly expressed and restricted to neuroprogenitors suggesting that it is necessary for their proliferation. However, a more systematic expression analysis found abundant Atf5 expression in various mature neuron populations and surviving Atf5-/- homozygotes are smell defective, but also less territorial and display several anxiety-like behaviors, suggesting additional roles in the CNS for Atf5. Furthermore, it is also expressed in other organs (liver, bones) in which it promotes differentiation of progenitor cells. Taken together, Atf5 function appears strongly context-dependent and additional work in physiological environments is needed. ATF5 is well conserved with two highly identical paralogs in Zebrafish: atf5a and atf5b. Here, we present the developmental expression patterns for both genes from 6-hour post fertilization (hpf) to 5-day post-fertilization (dpf), established by whole-mount in-situ hybridization (WISH) and semi-quantitative retro-transcription PCR (RT-PCR). We found ubiquitous maternal expression for both genes. From 2dpf onward, we found both genes expressed in the sensory epithelia of the inner ear. However, only atf5a was strongly expressed in the olfactory placodes and pits, with a weak and transient expression in the lateral line (LL). On the contrary, atf5b was not expressed in the nose and strongly expressed in the LL. Discrete bilateral regions in the midbrain and hindbrain were stained and partially overlapping at later developmental stages, with an earlier onset and broader staining for atf5a. Our work will facilitate future functional analyses in a genetic tractable animal model. Fig.2. Expression of atf5a and atf5b in the sensory lateral line (LL). (A, B, C) atf5a antisense mRNA probe hybridization in lateral view of whole-larvae at 2, 3 and 5dpf, with high- magnification (D,E,F) of NM corresponding to each developmental stage. (G,H,I) atf5b antisense RNA probe hybridization in lateral view of whole-larvae at 2, 3 and 5dpf, with high magnification (J,K,L) of NM to the left. SB: A,G= 200um, D,E=15um. Conclusions and Perspectives atf5a/atf5b mRNAs are maternally contributed at 6hpf. atf5a is strongly expressed in olfactory organs, specifically in OSNs, while weakly expressed in LL. atf5b is strongly expressed in LL while not found in olfactory organs. Both genes are expressed in the developing brain, presumably neurogenic areas. Single and double-knock outs will shed light into the function of each in tissues described here. Fig.3. atf5a/atf5b expression in developing inner ear. (A,B,C) atf5a antisense RNA hybridization in the three cristae and maculae of the inner ear. (D,E,F) atf5b antisense RNA hybridization. SB: O,P=40um Fig.5. atf5a/atf5b expression in developing brain. (A,B,C) atf5a antisense RNA hybridization in dorsal view of undissected (A) and dissected (B,C) larval brains. (D,E,F) Same for atf5b. SB: A,B, = 150um. We performed whole-mount in-situ hybridization using antisense RNA probes for both paralogous genes (atf5a and atf5b). Their expression profile in zebrafish larvae, starting at 2dpf, is described below. Fig.4. atf5a expression in olfactory organ. (A,B,C) atf5a antisense RNA hybridization in dorsal view o | poster |
ATYPICAL ASPECT OF EWING SARCOMA A RARE CASE REPORT Authors: Paul-Mihai Boarescu, Dan Gheban, Ioana Chirilă 1 ¹ Iuliu Haţieganu University of Medicine and Pharmacy Cluj-Napoca Introduction Bone sarcoma is a rare disease, with an incidence of approximately 8 cases per million/year. It occurs in all ages but has a characteristic bimodal distribution, with peak incidences for adolescents and elderly. Ewing Sarcoma (EWS) is a mesenchymal-derived tumor that generally arises in bone and soft tissue. Intensive research regarding the pathogenesis of EWS has been insufficient to pinpoint the early events of Ewing sarcomagenesis. Results An 11 years old male child was admitted to Children Hospital Cluj for evaluation. At the physical examination a poorly delimitated tumor in the anterolateral muscle lodge of the shin was found. Tumor was adherent to the fibular periosteum. Biopsy was taken from the lesion. Case presentation At macroscopic examination the tumor of 6/3/2cm had yellow color and strong elastic consistency. Histopathological examination reveals a malignant structure of the tumor with small and blue cells infiltrating the muscle and periosteum. Tumor cells are arranged in islands separated by a well-represented conjunctive vascular tissue. In patches islands have a compact aspect but there are also islands with intercellular spaces giving it an alveolar aspect , cells have a syncytial aspect. Focal ischemic necrosis and capillary vascular permeation images are seen. Margins of the tumor piece are positives. PAS stain was focally positive. Immunohistochemistry showed an intense and diffuse positive reaction for CD99, while DES and SMA remained negative on tumor cells. Also ACL was negative, while S100 stain showed some focal stains to isolated tumor cells. Conclusion The histological aspect of the tumor using HE resembles with alveolar rhabdomyosarcoma but immunohistochemistry clearly proves that it is a neuroectodermal tumor type, like Ewing Sarcoma. For a better differential diagnosis between the two entities, Actin staining for nonspecific muscle staining and / or Myogenin would be required. Key words pediatric patient, Ewing sarcoma, alveolar rhabdomyosarcoma, immunohistochemistry References Harms D, Leuschner I, Krams M, Pilgrim TB, Treuner J.Rhabdomyosarcoma and extraosseous Ewing's sarcoma. Verh Dtsch Ges Pathol. 1998;82:83-98. Goldblum JR,Weiss SW, Folpe AL. Enzinger and Weiss's Soft Tissue Tumors, 6th Edition, ed. Elsevier, 2013 Fletcher CDM. Diagnostic Histopathology of Tumors, 4th Edition , ed. Elsevier , 2013 | poster |
Water depth m -137 -900 failure affecting both post-glacial sediment drifts and older deposits: pressure ridges & slide blocks failure affecting only the flanks of post-glacial sediment drift deposits: thin skinned mudflows 5 km HE106 MKR18 MKR12 MKR13 MSC01-424 MSC01-301 fault P7 P4 P3 P8 affected deposits of the last sea-level fall and low stand erosive surface (ES1) Mud flow deposit (8,5 Cal. ky BP) affected post-glacial sediment drifts and drapes (unconsolidated muds) Twin Slides (Late Holocene) Northern Slide: remolding of slope deposits (pressure ridges) Southern Slide: affected oklder consolidated (and faulted) deposits of last s.l. fall generating a blocky slide Large Slide during last-glacial low stand (ca. 25ky BP) post glacial sediment drift and drapes Post Slide deposits Phase I Phase II Phase III Phase IV Sicily Gela Basin Italy 0 340 Kilometers SUBMARINE SLIDES Exposed Buried -800 -850 -200 -450 -400 -700 -750 -600 -300 -650 -350 -250 -550 -200 -250 -200 2 km 75 m SE NW profile HE 106 Northern Twin Slide Southern Twin Slide fluid-escape structures stacked mass-transport deposits basin-wide mass-transport deposit (Father Slide - last glacial) fluid-escape structures CHIRP sonar profile MKR12 S N Thick debrite accumulation Frontally-emergent MTD Frontal ramp Basal shear surface 1000 m 30 m Shallow-seated headwall Undisturbed seafloor S N CHIRP sonar proflile MKR13 Disturbed seafloor sector Buried MTD Potential “horse” Frontally-confined MTD 1000 m 30 m Distal sector with disrupted stratigraphy Central sector with folds and preserved stratigraphy Blocky area Debrites Buried MTDs CHIRP sonar profile MKR18 SE NW Shelf Deep-seated headwall Blocky area Debrites Elongated ridges Debrites Sidewall 1000 m 100 m TWIN SLIDES Where older and more consolidated units are mobilised, they result in more blocky slides, while younger and shallower units generated mudflow and plastic deformation of seafloor sediment resulting in distinctive pressure ridges in the toe region. REFERENCES MINISINI D., TRINCARDI F., ASIOLI A., CANU M., FOGLINI F. (2007) - Morphologic variability if exposed mass-transport deposits on the Eastern slope of Gela Basin (Sicily Channel). Basin Research, 19: pp. 217-240. MINISINI D. & TRINCARDI F. (2009) - Very high frequency failure of the continental slope: the Gela Basin (Sicily Channel). Journal of Geophysical Research, Vol. 114, F03014, doi:10.1029/2008JF001037. TRINCARDI F. & ARGNANI A. ( 1990) - Gela submarine slide: a major basin-wide event in the Plio-Quaternary foredeep of Sicily. Geo-Marine Letters, 10: pp. 13-21. TRINCARDI F., CATTANEO A., CORREGGIARI A., RIDENTE D. (2004) - Evidence of soft-sediment deformation, fluid escape, sediment failure and regional weak layers within the late-Quaternary mud deposits of the Adriatic Sea. Marine Geology, 213: pp. 91-119. VERDICCHIO G. & TRINCARDI F. (2008) - Mediterranean shelf-edge muddy contourites: example from Gela and South Adriatic Basins. Geo-Marine Letters, 28: pp. 137-151. DOI 10.1007/s00367-007-0096-9. FAILURE RECURRENCE Basin-wide correlation of Father Slide (generated on the onset of the Last Glacial Maximum) allows definition of at least six younger failure events (black dots) during the last 24 ky. This evidence implies a remarkable recurrence interval of ca. 4 ky (Minisini & Trincardi, 2009). Mass-transport deposits are up to 30 m thick and appear either shallowly buried or exposed at the seafloor. In both cases individual mass-transport deposits mobilize relatively small sediment volumes (typically in the order of 0.1-1 km3) and display modest run outs: - high-resolution multibeam data reveal several coalescing shallowly buried or exposed slides - CHIRP sonar profiles document recurrent failure events since the last glacial (about 20-25 ky BP). The margins of Gela basin, a 1000-m-deep slope basin in the Sicily Channel (Central Mediterranean), show evidence of widespread and recurrent sediment failure during the late Quaternary. Where exposed a | poster |
1.Background and Goal of the present work Paper materials are mainly of vegetative origin and contain cellulose and lignin as major structural constituents. Due to the deterioration by acid catalyzed hydrolysis, degradation of lignin, microbial and insect attacks, the material becomes brittle, frag- ile and discoloured and hence reinforcement is required in order to preserve the ar- chaeological and cultural value as well as the knowledge contained. Out of numerous techniques developed for paper conservation, gamma radiation in- duced graft copolymerization technique developed by the British Library in 1980s, possessed unique features of the possibility of internal grafting by the high penetra- tion power of gamma radiation, no remaining toxic residues and suitability to bulk and routine applications. Since resins and monomers with reactive unsaturated bonds, predominate in radiation curing techniques, acrylic monomers and unsaturated poly- ester/styrene mixtures widely utilized in conservation of organic materials. The present study is focused on the potential of utilizing inexpensive and readily available commercial alkyd resin for the reinforcement of naturally aged paper by gamma radiation induced graft copolymerization. 2. Experimental procedure 2.1. Analysis of the alkyd resin Commercial grade resin with undisclosed composition was utilized for the study and so it was analyzed for: Fatty acid composition Unsaponifiable matter content – ISO 6744-3 Material identification by GC-MS and FT-IR Physical properties (Viscosity, hardness, gloss & drying time) - in compliance with the standards used in the paint industry 2.2 Treatment of naturally aged paper The naturally aged paper samples were treated with chemical formulations containing mixtures with variable concentrations of alkyd resin and methyl methacrylate (MMA) and mixtures with variable concentrations of alkyd resin and styrene, followed by irra- diation. Gamma radiation dose of 15 kGy (at a dose rate of 0.33 kGy/hr) was utilized for the study, in order to achieve complete polymerization with minimum radiation damage to paper material. 2.3 Characterization of treated paper In order to determine the effectiveness of treatment, the samples were subjected to: Gravimetric measurement - to determine the polymer deposition yield Visual examination – to identify the alterations Scanning Electron Microscopy (SEM) Tensile strength - ISO 1924-2: 2008 Tearing resistance - ISO 1974: 2012 Water Absorbency - Total immersion method 3. Results and Discussion 3.1. Alkyd resin composition Oleic acid (C18:1) and Linoleic acid (C18:2) were identified as the major unsaturated fatty acids and they account for 49.2% and 7.5% of mass of extracted oil fraction of alkyd resin respectively. The resin contained 4.9% (w/w) of unsaponifiable matter. Number of aromatic compounds including phthalic anhydride, O-xylene, naphtha- lenes and ethyl and methyl benzenes were identified from the GC-MS. FT-IR peaks were in consistence with that of typical alkyd resin. 3.2 Physical properties of alkyd resin 3.3. Characterization of treated paper A positive correlation was observed between the polymer deposition yield and the res- in concentration, irrespective of the type of monomer. Testing Parameter Results Viscosity 240 s Hardness Passed Gloss 20° 25.3 60° 66.3 Drying time Surface (hrs) 2 Hard (hrs) 24 Alteration to the appearance of the treated paper samples was observed for higher al- kyd resin concentrations (30% and 40%) in both monomer solutions and hence Resin concentration of 20% was adopted for physical property evaluation. Comparison of SEM images of the control with the treated (20% of alkyd resin in MMA - Normal atmosphere) paper sample has been illustrated below and morphological changes indicate the sucess of graft copolymerization process. Comparison of SEM images of the control (top) with the treated (20% of alkyd resin in MMA) (bottom) Compared to the control, significant improveme | poster |
Ein Brief – zwei Perspektiven Stellenkommentare in digitalen Briefeditionen über APIs austauschen Ausgangssituation Ein Brief kann in mehreren Editionen publiziert und kommentiert vorliegen. In so einem Fall entstehen zum einen Kommentierungen, die in beiden Editionen ähnlich vorgenommen werden. Zum anderen werden aber auch Erläuterungen vorgenommen, die aus der spezifischen Perspek tive der Edition entstehen – d.h. mit Fokus auf diejenige Person, deren Korrespondenz ediert wird. Dadurch entstehen zwei Annotationslayer, die sich im Idealfall ergänzen. Die Einzelstellen kommentierung aus der jeweils anderen Edition kann also u.U. äußerst wertvoll für einen Nutzer sein. In digitalen Briefeditionen besteht nun prinzi piell die Möglichkeit, Daten aus anderen digi talen Editionen zu integrieren. Anstelle einer einmaligen manuellen Übernahme dieser Daten ist deren automatisierter Abruf über ein Appli cation Programming Interface (API) zu favori sieren. Daten aus externen Quellen können so schneller aggregiert, aktualisiert und zusammen mit den edierten Briefen angeboten werden. Im Regelfall liegen Einzelstellenkommentare in digitalen Briefeditionen heutzutage als Be standteil der TEI-XML-Dokumente vor (etwa im Element <note>). Sollen diese Kommenta re allerdings über eine Schnittstelle zur freien Nachnutzung durch externe Editionen angebo ten werden, müssen sie deutlich mehr Informati onen tragen, als das Element <note> im Kontext der Edition, z.B. Autor des Kommentars, Bezug stext etc. (siehe Codebeispiele rechts). Austauschformat Sinnvoll erscheint daher ein Datenformat, dass dediziert für den Austausch und die Aggregati on von Kommentaren, also vorwiegend textu ell vorliegender Annotation, konzipiert ist. Zwar wäre es möglich ein solches Format in TEI-XML neu zu definieren, allerdings gibt es für diesen Bereich bereits einen Standard, der auch schon breite Anwendung findet: das Web Annotation Data Model (WADM). Es wurde vom W3C entwickelt und im Februar 2017 offiziell als Recommendation aufgenom men. Gegenüber TEI-XML hat es den Vorteil, dass es alle notwendigen Angaben zu einem (Einzel stellen-)Kommentar kompakt vereint, wie die beiden Codebeispiele oben zeigen. Das WADM ist prinzipiell in mehreren Serialisierungen denk bar, allerdings wird JSON vom W3C empfohlen. correspSearch.net <TEI xmlns="http://www.tei-c.org/ns/1.0" xml:id="S00193"> 1 <teiHeader> 2 <fileDesc> 3 <titleStmt> 4 <title>Von Alexander von Humboldt. Hamburg, 28. Januar und 20. Februar 1791</title> 5 <editor> 6 <persName ref="http://d-nb.info/gnd/121069060"> 7 <forename>Franz</forename> <surname>Dumont</surname> 8 </persName> 9 </editor> 10 </titleStmt> 11 <publicationStmt> 12 [5 lines] <sourceDesc> 18 <msDesc rend="manuscript"> 19 <msIdentifier> 20 <institution>Freies Deutsches Hochstift / Frankfurter Goethe-Museum, 21 Frankfurt am Main</institution> 22 <repository>Autographensammlung</repository> 23 <idno> 24 <idno type="shelfmark">5051</idno> 25 <idno type="uri">http://kalliope-verbund.info/DE-611-HS-461600</idno> 26 </idno> 27 </msIdentifier> 28 </msDesc> 29 <pb n="1r"/> 55 <div type="writingSession" n="1"> 56 <opener> 57 <dateline rend="align(right)">Hamburg, den 28.ten Jan<ex>uar</ex> 1791.</dateline> 58 </opener> 59 <p> 60 <seg> 61 <orig>Fünf volle Monathe sind nun schon verflossen, seitdem ich die 62 <placeName key="S0022585">Rheinufer</placeName> verließ.</orig> 63 <note type="editorial">Im Juli 1790, nach der gemeinsam mit Forster den 64 Rhein hinab unternommenen Reise nach Belgien, Holland, England und 65 Paris, die vom 25.3. bis zum 11.7.1790 gedauert hatte.</note> 66 </seg> Wenn 67 Sie aus der Art, wie ich mich damals an Sie drängte, aus der frohen Stimmung, in 68 die mich jede Aeußerung Ihres Vertrauens und Ihrer liebevollen Zuneigung 69 versezte, auf Wärme und Herzlichkeit des Charakters in 70 mir schlossen, so muß es Ihnen jezt um so räthselhafter sein, daß Sie seit fünf 71 { 1 "@context": "http://www.w3.org/ns/anno.jsonld", 2 "type | poster |
Flex- Maßnahme Prakt. Potenzial Maschine Flex- Maßnahme Abruf Unternehmensplattform Marktplattform Intermediär Markt Flexnehmer n Marktplattform Praktisches PotenzialWerk Unternehmensplattform Demonstrator Abbildung: Daten- und Energiefluss Maschine Strommarkt Unternehmensplattform Marktplattform Unternehmens- plattform 1 Unternehmens- plattform n Maschinen Maschinen Unternehmen Von der Maschine zum Energiemarkt Die Rolle der Informations- und Kommunikationstechnologie Das Konzept der Energiesynchronisationsplattform Anwendung zum automatisierten Energieflexibilitätshandel Die Unternehmensplattform als Enabler Automatisierter Energieflexibilitätshandel > Daten- und Informationsflüsse > Entscheidung über Vermarktung/Inanspruchnahme von Flexibilitäten > Steuerung und Überwachung aller notwendigen Aktionen im Unternehmen Harmonisierung und Standardisierung von Schnittstellen > Flexibilität der Anlage wird über ein Kennzahlenset beschrieben > Alle Kennzahlen können sich im Betrieb laufend ändern >> Zustandsabhängigkeit der Flexibilität Dennis Bauer, dennis.bauer@ipa.fraunhofer.de Tel.:+49 711 970 - 1355 Marktplattform Unternehmensplattform Maschinen Unternehmen Marktplattform Unternehmensplattform Maschinen Maschinen Unternehmen 1 Unternehmen n Dienstleister Use Cases „proaktiv“ „reaktiv“ Einzellast aggregierte Lasten Einzellast aggregierte Lasten Eigene Entscheidung über Inanspruchnahme der Flexibilität Fremde Entscheidung über Inanspruchnahme der Flexibilität Energiesynchronisationsplattform 1. Bekanntgabe € bei P, t Wo / Wie kann die Flexibilität optimal genutzt werden? 2. Meldung des Lastgangs P, t 1. Bekanntgabe aktueller ∆P, t und € 2. Bekanntgabe t (Abruf) nationaler Markt (eex) regionaler Markt (otc) Energie- versorger Übertragungs- netzbetreiber Verteilnetz- betreiber regionale Ver- teilnetzbetreiber Regelleistung Börse Unternehmensplattform Marktplattform 1 2 Unternehmensplattform Manufacturing Service Bus (MSB) IaaS Schnittstelle Schnittstelle Marktplattform Service i Plattform Services Service j Iaas Provider Marktplatz für Services (Company Portal) Maschine / SPS 1 Maschine / SPS n Smarter Konnektor Angebot von Flexibilität Energieverbrauch Nachfrage nach Flexibilität Energieversorgung Energiesynchronisationsplattform Prozess- daten Steuer- signale Inserat Anfrage Produkt Abruf Fabrik m Prozess- industrie Fabrik 1 Prozess- industrie Maschine 1 Maschine 2 Maschine n Service Broker Registries Platform Services Domain Specifics System Data Space Service Data Space Service Layer Registrierte Services Energie- börse Last- optimierung Preis- prognose Wetterdienst … Aggregatoren Fabrik Maschine Entscheider Smarter Konnektor Wärmespeicher + Heizstab Zeit in min Leistung in kW Geldstrom in €/kWh Legende: P = Leistung ∆ P = Leistungsdifferenz t = Zeit € = Kosten Druckgussmaschine Elektrische Leistung Füllstand Zeit Unternehmen i i i Legende: MSB = Manufacturing Service Bus SPS = Speicherprogrammierbare Steuerung IaaS= Infrastructure as a Service Die Unternehmensplattform ist der Befähiger zum automatisierten Energieflexibilitätshandel mit Angeboten auf der Marktplattform. … nimmt Prozessdaten auf und ermöglicht eine Aggregation der Energieflexibilitätsmaßnahmen im Unternehmen. … unterstützt verschiedene Betriebskonzepte, um den individuellen Anforderungen der Unternehmen gerecht zu werden. 4 … ermöglicht ein Management der Maßnahmen sowie Services zur Optimierung des Einsatzes der Energieflexibilität. … bietet die einheitliche Schnittstelle zu verschiedenen Energiehandelsangeboten auf der Marktplattform. 3 Die Unternehmensplattform… 1 2 3 4 Das Konzept der Energiesynchronisationsplattform bildet eine branchenübergreifende Lösung zum Energieflexibilitätshandel. ... bietet ein durchgängiges Konzept für den automatisierten Energieflexibilitätshandel von der Maschine bis zum Energiemarkt. … identifiziert zusätzliche Services für die Aggregation, Verarbeitung und den Austausch von Daten. … gliedert sich in die beiden Teilplattformen | poster |
H-band de Boer et al. 2016 Searching for accreting protoplanets in transitional disks: SPHERE/ZIMPOL observations N. Huélamo (CAB, Spain), G. Chauvin, A. Lagarrigue, M. Benisty (U. Chile/IPAG), H.M. Schmidt, S. Quanz (ETH Zurich), E. Whelan (Maynooth Univ., Ireland), J. M. Alcalá (INAF, Italy), D. Barrado, B. Montesinos, I. Mendigutía (CAB, Spain) The project: When planets formed, they are surrounded by circumplanetary disks (CPDs). Different theories predict that magnetospheric accretion can occur from the CPD onto the planet. We aim at detecting accreting protoplanets within the gaps of transitional disks, using the Hα emission line as an accretion tracer. To achieve our goals, we have performed spectral angular differential imaging (ASDI) observations with SPHERE/ZIMPOL at the VLT. In this poster, we show our results for two transitional objects: the Herbig Ae star MWC758, and the T Tauri star RXJ1615.3-3255. RXJ1615.3-3255 RXJ1615.3−3255 0 100 200 300 400 distance to the star (mas) 12 10 8 6 4 2 0 Contrast−5σ (mag) CntHa NHa Diff Figure 3 – Left: SPHERE/IRDIS H-band image of RXJ1615 from de Boer et al. 2016, where several rings (R) and arcs (A), a gap (G), and an internal disk (I1) are detected. Right: SPHERE/ZIMPOL images of RXJ1615 in two individual filters (NHa & CntHa) and the difference image (NHa-CntHa). Figure 4: SPHERE/ZIMPOL 5σ contrast curves obtained in the two individual filters NHa and CntHa in ADI, and in the NHa- CntHa difference in ASDI. Preliminary curves obtained using Classical ADI. RXJ1615.3-3255: This T Tauri star (TTS) has been imaged by SPHERE/IRDIS in the near-IR (de Boer et al. 2016, Figure 3, left), and shows a disk with several structures: arcs, rings and a clear gap at 0.5 arcsec (79 au@158 pc). Our ZIMPOL ASDI dataset does not show any source within a 1” radius from the central star. Note that our preliminary analysis shows a contrast of 6 mag at 50 mas (8 au) in the ASDI image, and 8 mag at 200 mas (32 au) using classical ADI (cADI). (Huélamo et al., in prep.) SPHERE/ZIMPOL optical images Contrast curves Separation (mas/au*) Contrast NHa (mag) log LHα (L⦿) log Lacc (L⦿) log Macc (M⦿) 50 / 8 5.0 -5.0 -4.0 -8.4 100 / 16 7.6 -6.1 -5.3 -9.7 200 / 32 8.2 -6.3 -5.6 -10.0 Table 2: SPHERE/ZIMPOL Hα contrast, line and accretion luminosity at different separations from the star. We have also estimated the accretion rates (Macc) for a 1 MJup planet with 1 RJup radius. MWC758: This Herbig Ae star is surrounded by a disk with several spiral arms. Reggiani et al. (2017) reported the detection in the L’-band of a planet companion candidate at 111 mas (see Fig. 1, left). We do not detect it in the SPHERE/ZIMPOL images. Note that we reach a contrast of ~8 mag at 111 mas (see Fig. 2) in the ASDI image. MWC758 (Huélamo et al. 2018) Figure 1 – Left: L’-band image of MWC758 from Reggiani et al. 2017. The spiral arms in the disk (S1, S2 and S3), together with the protoplanet candidate (b), are marked. Right: SPHERE/ZIMPOL images of MWC758 in two individual filters centered in the Hα line (BHa) and the adjacent continuum (ContHa), and the differential image (BHa-ContHa). The red circle shows the position of the L’ source detected by Reggiani et al. 2017. L’-band SPHERE/ZIMPOL optical images Reggiani et al. 2017 0 100 200 300 400 12 10 8 6 4 2 0 0 100 200 300 400 distance to the star (mas) 12 10 8 6 4 2 0 Contrast 5σ (mag) 0 100 200 300 400 distance to the star (mas) 12 10 8 6 4 2 0 Contrast 5σ (mag) CntHα BHα BHα−CntHα Figure 2: SPHERE/ZIMPOL 5σ contrast curves obtained in CntHa, BHa in ADI, and in BHa-CntHa in ASDI. The grey area shows the separation of the companion candidate detected in L’. Contrast curves planet candidate separation * distance ～158 pc (GAIA DR2) NHa -400 -200 0 200 400 ∆ RA (mas) -400 -200 0 200 400 ∆ DEC (mas) CntHa -400 -200 0 200 400 ∆ RA (mas) -400 -200 0 200 400 NHa - CntHa -400 -200 0 200 400 ∆ RA (mas) -400 -200 0 200 400 Separation (mas/au*) Contrast BHa (mag) log LHα (L⦿) log Lacc (L⦿) | poster |
Low high Radiation Phylum Javier Edo Varg, Pablo Burraco, Sergey Gaschack & Germán Orizaola Genus Abundance % Abundance % medium Low high Radiation medium Bacteria Unclassified Bacteroidetes 16S Library DNA Extraction MiSeq illumina Seq Chlamydiae Cyanobacteria Firmicutes Proteobacteria Tenericutes Environmental pollution can inflict biological damage to organisms affecting their life histories. Here, we use the Eastern treefrogs (Hyla orientalis) as study model , to examine the consequences that living ir areas contaminated by radioactive material from the Chernobyl accident, occurred in 1986, had on the diversity and composition of gut microbiome. We collected 80 individuals in five localities inside the Chernobyl Exclusion Zone during the spring 2017, one locality under high radiation levels (> 11 microSv/h), two on mid radiation (2-4 microSv/h) , and two on low radiation levels (< 0.11 microSv/h). The long-term exposure to ionizing radiation on Chernobyl can give us information about negative effects of the radiation, as well as insights into putative adaptation patterns in these organisms. The duodenum of the frogs was preserved for DNA extraction in situ. The region between 515F and 806R of the 16S rRNA was targeted and amplified through PCR. Specific Illumina barcodes i5 and i7 were used to make the Illumina libraries. The resulted amplicons were sequenced on an Illumina Miseq at the Science for Life laboratory (Uppsala University, Sweden) to estimate total microbial diversity. The sequencing resulted in 1382 filtered Operational Taxonomic Units (OUTs). The OTUs were clustered at 97% of identity and showed a high percentage of Proteobacteria, Firmicutes, and unassigned bacteria. The composition of the gut microbiome in Hyla orientalis differed between radioactive contamination levels. Further studies are needed to fully understand the implications of these differences, as well as their possible effects on organismal fitness. Effects of long term exposure to ionizng radiation on Chernobyl treefrogs gut microbiome Bacteria Unclassified Phylum Cyanobacteria Family Clostridiaceae Clostridium_sensu_stricto_1 Tyzzerella_3 Anaerotruncus Verticia Ralstonia Family Enterobacteriaceae Methods Results Conclusions C o l l e c t i n g https://www.resear- chgate.net/profile/- Javier_Varg https://twitter.- com/jedovarg https://orcid.org/0000-0002-7895-4563 https://www.linke- din.com/in/ja- vier-edo-varg-varg- a9509b60/ https://www.insta- gram.com/javiere- dovarg/ #VargPhD The genus Tyzzerella is found only in frogs with a high level of radiation The phylum Firmicutes and Proteobacteria are significantly different between radiation levels Project still in progress Acknowledgement 16 65.3 16.6 7.3 81.8 10.2 7.9 15.4 76.6 5.2 9.1 42.7 25.8 10.7 7.9 13.5 6.3 13.9 49.7 8.9 61.7 5.3 15.9 | poster |
COUNTRY/REGION KEY WORDS sustainability, technological in- novations, practices, small and medium-sized industry, rural areas DISCLAIMER This Practice Abstract reflects only the author’s view and the Branches project is not responsible for any use that may be made of the information it contains. 43 Specialty heartwood timber from oversized Scots pine logs Natural Scots pine heartwood is a valuable resource because of extractives, which make it moisture and decay resistant. The older and larger the tree gets, the more heartwood it contains. Most of the sawmills are unable to saw oversized logs rich in heartwood and thus the fate of the valuable logs would be in energy production as wood chips. Since 1994 the family owned business Finnstamm Oy has been specialized to saw extra large knot-less butt logs of Scots pine. According to the Scandinavian standards those logs are oversized for other sawmills. The logs come from PeFC-certified sources and are sawn to high quality heartwood timber for the woodworking and furniture industry. Dimensionally stable solid heartwood material without any adhesive layers is especially suitable for window and door frames. For the sawing, the butt logs with high heartwood proportion are selected and then guided through metal detector. The butt end is reduced and debarked and got through an extra large horizontal saw and circular saw. The saw may be used to radial cutting, which makes the timber more weatherproof and increases the durability. A customer specifies the drying method, which can be performed in a three-chamber hot air drying kiln or in open- air. The dry timber is guided to cut-off line and planing, if needed. After packaking the product is ready to be dispatched to the customer. Use of durable wood in constructions increases the storage time of carbon and provides foundation for the recovery of wooden building materials. Now that the era of hazardous super-effective wood preservatives is over, more benign solutions are searched for to attain optimal durability. Durability related characteristics of Scots pine heartwood have been studied in Natural Resources Institute Finland (Luke). DOWNLOAD www.branchesproject.eu AUTHORS Heikki Rytkönen (Finnstamm) Anni Harju (Luke) Martti Venäläinen (Luke) | poster |
VISUALIZING DIGITAL COLLECTIONS User-Friendly Search and Browse Tools Digital Archive International History Declassified The Wilson Center Digital Archive contains declassified historical documents drawn from archives all over the world. Founded in 1991 to encourage access to newly opened archives in Eastern Europe, the first version of the Digital Archive was focused on historians and expert researchers. 50,000 pages of documents 100 different archives 24 different languages In 2013, the website was redesigned to make it more accessible for new users and students. Previously users could only “browse” through a list of thematic collections. The timeline updates to show the number of documents over time and a list of common subjects. Events like the Cuban Missile Crisis appear as spikes on the timeline. A simple visual interface provides users with a broad overview of our collections, giving them context to begin exploring. Users can use the interactive map to select a region, country or city of interest. stefaner.eu Open source facet browser which displays the proportion of items in each metadata category and allows users to visually filter results. viewshare.org Free platform developed by the Library of Congress to create new “views” for interacting with digital collections. neatline.org Add-on tools for Omeka that can create interactive exhibits by plotting objects, documents, and ideas against interlinked maps, timelines, and narrative text. Documents above: Soviet telegram with handwritten instructions from Stalin, 1947 (RGASPI); Draft of telegram by Mao Zedong, 1950 (PRCFMA) Free and Open Source Tools Laura Deal Catalog Specialist Woodrow Wilson International Center for Scholars Once users have identified a region, date, or subject of interest, they can view a list of results that can be further refined with the advanced search bar. Visual Browse New tools are becoming available every day which build on top of existing metadata and collection management systems. Data visualizations give users new ways of thinking about and exploring existing digital collections. Providing users with context to explore before they search Viewshare Elastic Lists Neatline | poster |
CROSS-SECTIONS FOR THE SOLAR NEUTRINOS CAPTURE AND CHARGE-EXCHANGE RESONANCES Grigory Koroteev MIPT Email: koroteev@phystech.edu Phone: +79252279046 Contact 1. Yu. V. Gaponov, Yu. S. Lyutostanskii, JETP Lett. 15, 120 (1972). 2. J. N. Bahcall, A. M. Serenelli, and S. Basu, Astrophys. J. Lett. 621, L85 (2005) 3. N. Borzov, S. A. Fayans, E. L. Trykov. Nucl. Phys. A 584, p. 335 (1995). 4. Yu. S. Lutostansky JETP Lett. 106, 7 (2017). 5. A.A. Borovoi, Yu.S. Lutostansky, I.V. Panov, et. al., Pis’ma Zh.Eksp.Teor.Fiz. 45 №11, 521-523 6. Krofcheck D., et al. Phys. Rev. Lett. 1985. V.55. P. 1051; 7. Yu.S. Lutostansky, N.B. Shulgina. Phys. Rev. Lett., 1991, v. 67 8. Yu. Lutostansky. Physics of Atomic Nuclei, 2011, Vol. 74, No. 8, pp. 1176–1188 9. M. Palarczyk, et. al., Phis. Rev. 59 10. J. Rapaport, P. Welch, J. Bahcall, et al. Phys. Rev. Lett. 54, 2325 (1985) References Investigation of charge-exchange resonances is important for calculating neutrino capturing cross- sections σ(E) of nuclei that can be used in neutrino detectors. Analog resonance, Gamow-Teller resonance (GTR) and three pigmy resonances are selected. Calculations were performed using the self-consistent theory of finite Fermi systems for Ga-71, Mo-98 and I-127. Even not accounting GTR gives a decrease of the σ(E) value more than 25%. Numbers of events in the interaction of solar neutrinos with these three nuclei calculated. It is shown that boron neutrinos make the main contribution and it is important to take into account all resonances. Abstract Nuclear Resonances Theory - The are 3 types of the charge-exchange allowed resonances: Gamow–Teller and the analog resonances, and pygmy resonances. - They can be good described using microscopic theory and in model approximation. - The calculated values of the energies of Gamow–Teller and analog resonances, are in good agreement with their experimental data. - Pygmy resonances may be described using the same approach as for Gamow–Teller and analog resonances. - The role of pygmy resonances is very important in the charge-exchange reactions and in neutrino capturing and beta-delayed process. Conclusions Neutral ( ΔQ = 0 ) and charge ( ΔQ = 1 ) excitation branches of nuclei. Gamow–Teller resonance (GTR), analog resonance (AR), and three pygmy resonances (PR1, PR2, PR3) are indicated for the A(N-1,Z+1) nucleus. [1] Q E e e e A dE E Z F E S E p c g E 0 4 3 . 2 ) , ( ) ( ) ( M2GTR ≈ 3 (N-Z) eq2 M2IAS ≈(N-Z) where Vpn and Vpn h are the effective fields of quasi- particles and holes, respectively; Vpn ω is an external charge-exchange field; dpn 1 and dpn 2 are effective vertex functions that describe change of the pairing gap Δ in an external field; Γω and Γξ are the amplitudes of the effective nucleon–nucleon interaction in, the particle–hole and the particle–particle channel; ρ, ρh, φ1 and φ2 are the corresponding transition densities. [3] Local nucleon–nucleon δ-interaction Γω in the Landau-Migdal form used: Г= С0 (f0′ + g0′ σ1σ2) τ1τ2 δ(r1- r2) where coupling constants of: f0′=1.35 – isospin- isospin and g0′=1.22 – spin-isospin quasi-particle interaction with L = 0. [4] Constants f0′ and g0′ are the phenomenological parameters. n p n p p n np, pn q pn Г V e V The Gamow–Teller resonances and other charge- exchange excitations of nuclei are described in Migdal TFFS-theory by the system of equations for the effective field: n p h n p p n np, h pn Г V n p n p p n np, pn Г d 1 1 n p n p p n np, pn Г d 2 2 Matrix elements MGT : where χλν – mathematical deductions 2 1 2 1 2 1 2 1 2 V A M GT G -T values are normalized in FFST: i q i Z N e M ) ( 3 2 2 Effective quasiparticle charge is the “quenching” parameter of the theory. 0.1 8.0 2 qe Yury Lutostansky1, Alexey Osipenko1, Victor Tikhonov1, Almaz Fazliakhmetov2,3, Grigory Koroteev2, Andrey Vyborov2,3 1National Research center ”Kurchatov Institute”, Russi | poster |
Challenges Of Using Homomorphic Encryption In Machine Learning Soumia Zohra El Mestari SnT, University of Luxembourg Introduction Homomorphic Encryption (HE) is a form of public key encryption that allows evaluating a function on encrypted data without the need to decrypt [3, 1]. The adoption of HE in Machine Learning (ML) contexts faces many challenges, namely: • Non support for non linear functions • Noise growth • Secret key recovery attacks Non support for non linear functions Fully Homomorphic Encryption (FHE) schemes so far only support addition and multiplication hence machine learning activation functions are then not supported for direct FHE evaluation. There are three commonly used methods to support non-linear functions: • use a polynomial substitution • pre-compute function for discrete values and store these values in look-up tables • use low-degree polynomials to approximate the non-linear functions All these methods are approximations so they cause a precision loss in the case of inference and additional convergence time if we train on homomorphically encrypted data. Noise growth Approximate FHE schemes like CKKS [1] decrypt to an approximated value of the original message. Figure: Approximate Homomorphic encryption evaluation The sources of noise are caused by the encoding and the noise growth after each operation with the multiplication having the most noise growth scale. The bootstrapping operation despite being one of the solutions to reduce the noise in ciphers is computationally expensive and hence the homomorphic evaluation of deep neural networks for example can face large computation overheads. Secret key discovery attacks When using approximate numbers schemes like CKKS [1], a passive attacker having access to ciphers and their decrypted versions can recover the secret key by analysing the noise growth in ciphers; in fact, the results are approximated, and the IND-CPA security does not offer sufficient protection. Figure: Secret key recovery attack on CKKs [1] Such a devastating attack can be mitigated by injecting an additional Gaussian noise during the decryption which will make the precision decrease. Conclusion The adoption of HE in ML systems is promising, multiple attempts ( such as CryptoNets [2] ) started emerging HE inference as attempts to offer confidentiality level of privacy to machine learning tools. References [1] J. H. Cheon, A. Kim, M. Kim, and Y. Song. Homomorphic encryption for arithmetic of approximate numbers. In International Conference on the Theory and Application of Cryptology and Information Security, pages 409–437. Springer, 2017. [2] R. Gilad-Bachrach, N. Dowlin, K. Laine, K. Lauter, M. Naehrig, and J. Wernsing. Cryptonets: Applying neural networks to encrypted data with high throughput and accuracy. In International conference on machine learning, pages 201–210. PMLR, 2016. [3] P. Martins, L. Sousa, and A. Mariano. A survey on fully homomorphic encryption: An engineering perspective. ACM Computing Surveys (CSUR), 50(6):1–33, 2017. Acknowledgements This work has been funded by the European Union’s Horizon 2020 Innovative Training Networks, Legality Attentive Data Scientists (LEADS) under Grant Agreement ID 956562 Contact information • Email: soumia.elmestari@uni.lu 1/1 | poster |
Related Literature [1] Maria Roussou and Akrivi Katifori. 2018. Flow, Staging, Wayfinding, Personalization: Evaluating User Experience with Mobile Museum Narratives. Multimodal Technol. Interact. 2, 2 (June 2018), 32. DOI:https://doi.org/10.3390/MTI2020032 [2] Akrivi Katifori, Maria Roussou, Irene Kaklopoulou, Katerina Servi. 2019. Mobile interactive storytelling in the Athens Ancient Agora: exploring the right balance between the Site and the App, XVII. Culture and Computer Science, May 23-24, 2019, Konzerthaus Berlin. [3] Akrivi Katifori, Sara Perry, Maria Vayanou, Angeliki Antoniou, Ioannis-Panagiotis Ioannidis, Sierra McKinney, Angeliki Chrysanthi, and Yannis Ioannidis. 2020. “Let Them Talk!”: Exploring Guided Group Interaction in Digital Storytelling Experiences. J. Comput. Cult. Herit. 13, 3 (August 2020), 1–30. DOI:https://doi.org/10.1145/3382773 Conclusion The approaches followed within the three projects, αlthough they differ from one to another, because of variations in archaeologists’ needs, the scope of the experience, and the site’s characteristics, all of them draw inspiration from the monuments, the historical events, and the people to deliver pertinent information as effortlessly as possible. The aim is to engage the user emotionally with the people who lived in ancient Eleusis, Arta and Epidaurus, to understand their needs, desires, habits, and different perspectives, and to transform his or her connection to the history and the archaeological site from the level of simple knowledge into a deeper, multilevel, and rich experience. A multi-layered experience through space and time in the archaeological sites of Arta In Voeska, a multi-layered experience has been adopted that runs through space and time. Considering the uniqueness of Arta and the fact that it has three charming historical faces, a flexible core idea was chosen, which finds application in different periods and offers the ability to link objects to spaces. The focus of the idea is a scribe, who undertakes to write a series of letters, which are ordered by his clients. The Epistles cover all time periods and involve a wide range of people: men, women, aristocrats, peasants, craftsmen, artists, kings. The persons who send and receive the letters could be fictitious or real or both. The main advantage of this idea is that it can include a variety of themes, so as to create a "mosaic" in which each piece is independent, but all together create a broader and timeless image of Arta, while touring the city. Moreover, it effortlessly links fiction to specific objects and sites, and in fact, each Epistle can link more than one object to more than one site. Utilizing the main components of fiction, the selected approach activates historical empathy. A linear digital storytelling experience connecting the past with the present of the underwater antiquities of Epidaurus In Periplous, α journey aboard a boat with transparent bottom is accompanied by an automated guided tour, where the digital experience complements the physical one in real time as the visitors float above the underwater antiquities of Epidaurus. The boat follows predetermined routes and stops mid-sea while providing descriptions and narrations. Α linear approach for the digital storytelling experience is adopted, connecting the past with the present. Within this context, visitors will be able to discover ‘hidden’ information in a series of points of interest, called "Snapshots”, including pre- recorded narrations or conversations connected to the archeological findings and representing everyday life in the ancient times. The participants in the dialogues are either ‘ancient people’ who lived in Epidaurus, as represented through fictional dialogues, or the real archaeologists, who have undertaken the excavation and the conservation of the specific archeological site. An interactive digital storytelling experience in ancient Eleusis In myEleusis, an interactive digital experience unfolds through | poster |
The Tonal Comparative Method: Tracing Sound Change in Lexical Tone Rikker Dockum The Comparative Method We can deconstruct the Comparative Method to first principles and rebuild it in a way that allows for tonal evidence What do sound change rules like this pick out from the language? *p > b / V_V o The object of comparison in the CM is lexical subsets that pattern together in a particular conditioning environment o When viewed in this way, lexical tones with their segmental origins are a natural fit Building the missing evidence Expanding the Comparative Method SUMMARY: Linking tones to their segmental origins helps us to use tonal evidence in language classification and reconstruction in a methodologically sound way Lexical tone and the Comparative Method The Kra-Dai languages o ~100 languages o ~100 million speakers (Edmondson & Solnit 2008) Tai is the most populous branch o ~80 million speakers o Thailand 65+ million o China 15+ million o Laos 4+ million o Myanmar 3+ million o And more in India, Vietnam, Cambodia, Malaysia o The Comparative Method has long been the main tool of linguists for figuring out what past stages of a language sounded like without direct evidence o Systematic comparison of cognate words in related languages o Working backwards from the present and inferring sound changes in daughter languages o The main tool of linguists for determining genetic relationships between languages, and reconstructing common ancestors (i.e. proto-languages) The segmental origins of tone o Lexical tone, the use of pitch to encode word meanings, has often been thought to be unusable with the Comparative Method (e.g. Meillet 1948, Campbell 2003) o The origin of tone compensates for loss of segmental contrasts o But after initial tonogenesis, tones vary and change in ways still poorly understood Why do tones change? o Sound change is constantly happening o Both conditioned changes and random drift, just as with segments “[past use of Tai tonal evidence] is not consistent with the shared-innovation method used in subgrouping, because many tonal changes may not in fact be shared innovations … A subgrouping proposal for Southwestern Tai should primarily use as criteria consonantal and vocalic changes that can be shown empirically to have occurred relatively early.” (Pittayaporn 2013:306) What is missing? o In the traditional Comparative Method we have a large body of accumulated knowledge, the received wisdom of what kinds of sound changes are more or less likely than others o Key to the scientific validity of the method is having generally reproducible principles for distinguishing retentions and innovations from chance resemblance (Weiss 2015) o There is no body of received wisdom for sound change in lexical tone, no accumulated knowledge of which sound changes are more or less likely “…prosodic change seems fully tractable in terms of analytical methods ... time-tried for other aspects of phonological change … on the other hand, there is as yet so much to be learned … the present lack of data may enforce, at a minimum … one or two generations of waiting until two or more richly described contiguous points in time are available for comparison” (Janda and Joseph 2003:117) Tone in the Tai languages Proto-Tai had three tones on open syllables/sonorant codas: A B C *hmaA ‘dog’ *hmaB ‘to soak’ *hmaC ‘to grow, rise’ The 3-tone system of Proto-Tai split into more tones based on the laryngeal configuration of onset consonants: Each daughter language carves up the ‘tone box’ (Gedney 1972) differently. For example, here is Standard Thai (each color represents a surface tone): A B C Voiceless w/ friction A1 B1 C1 *pʰ, *tʰ, *s, *ʰm, etc. Voiceless unaspirated A2 B2 C2 *p, *t, *k, etc. Glottalized A3 B3 C3 *ʔ, *ʔb, *ʔj, etc. Voiced A4 B4 C4 *b, *m, *l, *z, etc. A B C Voiceless w/ friction khaː24 ‘leg’ khaː22 ‘galangal’ khaː41 ‘servant’ *pʰ, *tʰ, *s, *ʰm, etc. Voiceless unaspirated ka33 ‘crow’ kaj22 ‘chicken’ klaː41 ‘seedling’ *p, *t, *k, | poster |
Constraining Gas Disk Structure in MY Lupi with UV and Submillimeter Models Nicole Arulanantham1, Paolo Cazzoletti, Simon Bruderer, Anna Miotello, Ewine van Dishoeck, Kevin France, Keri Hoadley Contact: narulanantham@stsci.edu Giacconi Fellow, Space Telescope Science Institute This project has been supported by a NASA Earth and Space Science Fellowship (NESSF) and HST-GO program 14469 (co-PIs: C.F. Manara, P.C. Schneider). Physical-chemical models generate detailed maps of carbon, nitrogen, oxygen, and hydrogen bearing molecules in protoplanetary disks. However, the vertical disk structure in these models is degenerate with the amount of UV flux reaching the gas. Flat, strongly irradiated disk models and flared, weakly irradiated systems produce similar integrated line fluxes, which makes it difficult to examine UV sensitive photochemical pathways at disk radii where submillimeter gas emission cannot yet be spatially resolved. How does the multi-wavelength modeling approach work? The 2-D distributions of vibrationally excited molecular hydrogen from each DALI model are irradiated with LyA photons, which pump the gas into excited electronic states. The resulting fluorescent emission lines are compared directly to observed UV features in HST-COS spectra of MY Lupi, showing that the H2 lines are best fit by a flared disk model with strong FUV irradiation and a high gas mass. Can multi-wavelength spectroscopy break the degeneracy between vertical disk structure and UV irradiation of the gas? We investigate whether ultraviolet emission lines from fluorescent molecular hydrogen can be used to break this degeneracy, by using the Dust and LInes (DALI) code (Bruderer et al. 2013) to model CN emission in the disk around MY Lupi. We have chosen MY Lupi as a prototype, since its flaring angle has been directly measured from scattered light observations (see below). How can we study the composition and distribution of gas in regions of protoplanetary disks where rocky planets form? Flat disk, high UV Flared disk, low UV z/r r [au] r [au] H-band scattered light image of MY Lup (Avenhaus et al. 2018), which constrained the disk flaring angle (ψ = 0.21 ± 0.03) z/r N + H⇤ 2 −! NH + H C+ + NH −! CN+ + H CN+ + H −! CN + H+ Visser et al. 2017, Cazzoletti et al. 2018 Pumped by Lyα to produce UV- H2 emission Outstanding question: do any disks show UV-H2 emission lines that look like the flat disk model? We conclude that molecular emission lines from UV spectra can provide important constraints for physical- chemical models of gas disks. However, further observations are required to determine whether flatter disks produce UV-fluorescent H2 emission that looks like the models. | poster |
The exclusion criteria were: Previously diagnosed endometriosis, uterine leiomyomas, previous multiple surgeries, endocrinological disorders, and severe male factor infertility. Number Patient IUI İVF Pregnancy Term-Live Birth Clomiphene-1 Clomiphene-2 Clomiphene-3 Clomiphene-4 Letrozole-1 Letrozole-2 Letrozole-3 Follitropine-alfa 1 Follitropine-alfa 2 50 40 30 20 10 0 STUDY DESIGN The inclusion criteria were: Age between 20-39 years, basal FSH level < 10 mIU/ml, and body mass index<35 kg/m2. Patients who meet these criteria were included In the study program. One hundred thirty-six subfertile women who applied to the Obstetric and Gynecology Clinic at Bakırköy Sadikonuk Education and Research Hospital were allocated. Between February 2020 to January 2022, We accessed patient files from archive records. The patients were divided into two groups; use of clomiphene citrate (n=107) and letrozole (n=19). We gave follitropine alfa to some of the patients (n=19). LIVE PREGNANCY RATE AFTER OVULATION INDUCTION PROTOCOLS IN SECONDARY INFERTILE PATIENTS AUTHORS Mustafa Cengiz Dura1 Hilal Aktürk1 Murat Ekin2 AFFILIATIONS Bakırköy Sadikonuk 1Education and Research Hospital INTRODUCTION Ovulation induction protocols, including Clomiphene Citrate(Serm), GnRH analogs (GnRH agonist and antagonist), and Letrozole(aromatase inhibitor), are known and enumerated. Our study is cross-sectional and retrospective and obtained from the patients who applied to the infertility outpatient clinic and the hospital database between February 2020 to January 2022. RESULTS/FINDINGS OBJECTIVE İn this study, we aimed to investigate live pregnancy rates after variable ovulation induction protocols in secondary infertile patients. ANALYSIS CONCLUSION Our data found no significant difference in comparing ovulation induction protocols in live pregnancy at term. PARAGRAPH METNİNİZ It results in term pregnancy after ovulation induction; in secondary infertile patients. A significant relationship exists between previous pregnancies and live- term birth rates (p<0.05). At the same time, there is no significant relationship in live pregnancy after using clomiphene citrate, letrozole, and follitropine-alfa for ovulation induction. In our research, we use one after another Clomiphene Citrate first attempt (n=48) 38.1%, Clomiphene Citrate second attempt (n=42) 33.3%, Clomiphene Citrate third attempt (n=14) 11.1%, and Clomiphene Citrate fourth attempt (n=3) 2.4% rates. In another group, they take after another Letrozole first attempt (n=11) 8.7%, Letrozole second attempt (n=5) 4.0%, and Letrozole third attempt (n=3) %2.4 Nineteen patients take Follitropine-alfa .19 out of 16 patients take Letrozole after that; they take Follitropine-alfa when there is no adequate response; simultaneously, 107 out of 3 patients take Clomiphene Citrate after that; they take Follitropine-alfa. There was no significant difference between the groups in measurements after term delivery, marriage duration, infertility period, anti-mullerian hormone, follicular stimulating hormone, and spermiogram evaluation (p>0.05). TSRM 2022 10.ÜREME SAĞLIĞI VE İNFERTİLİTE KONGRESİ 10-13.KASIM 2022 GİRNE/KKTC Chart-1:Comparison of ovulation induction protocols in terms of live pregnancy at term. Figure-1:Comparison of ovulation induction protocols Total Number of Patient Number of secondary infertile patients Live pregnancy at term 136 126 29 | poster |
Data-driven model of striatal external input Ilaria Carannante1, Yvonne Johansson2, Johannes Hjorth1, Gilad Silberberg 2, Jeanette Hellgren Kotaleski1,2 1 KTH Royal Institute of Technology, Department of Computational Science and Technology, Stockholm, Sweden. 2 Karolinska Institutet, Department of Neuroscience, Stockholm, Sweden. The basal ganglia play an important role in a variety of functions including decision making and action selection mainly based on input from cortex, thalamus and the dopamine system. Striatum is the input stage of the basal ganglia. Here we present a new approach to model the postsynaptic currents mediated by NMDA or AMPA receptors which allows a more accurate description of them. Then we model the extrinsic inputs from cortex and thalamus to the different populations of striatal neurons (striatal projection neurons (dSPNs and iSPNs); cholinergic (ChIN), fast-spiking (FS), and low-threshold spiking (LTS) interneurons). We present a data-driven model of the postsynaptic currents mediated by AMPA or NMDA (average currents are shown in Fig2). We describe the dynamics using three exponentials: one for the rising and two for the decay phases. The use of three exponentials (instead of the generally used two) allows a more accurate description of the currents without compromising the performace of the models. A comparison between the different current models is shown in Fig3. We introduce a classification of the synaptic traces for each input region and each cell type. Traces belonging to the same class are normalized and the average trace is extracted. An example of this process is shown in Fig4. We simulate the extrinsic inputs by placing and stimulating the glutamatergic synapses on multicompartmental neuron models. These are based on detailed reconstructed morphology and include ion channels models according to RNA-seq data. An example of LTS models is shown in Fig5. The models are able to capture both subthreshold and suprathreshold current-voltage responses. [1] Hjorth, J. J., Kozlov, A., Carannante, I., Nylén, J. F., Lindroos, R., Johansson, Y., ... & Grillner, S. (2020). The microcircuits of striatum in silico. Proceedings of the National Academy of Sciences, 117(17), 9554-9565. [2] Johansson, Y., & Silberberg, G. (2020). The functional organization of cortical and thalamic inputs onto five types of striatal neurons is determined by source and target cell identities. Cell reports, 30(4), 1178-1194. [3] Uziel, A., & Markram, H. (2000). Synchrony Generation in Recurrent Networks with Frequency-Dependent Synapses. Journal of Neuroscience, 20(1), RC50-RC50. Funding: The study was supported by the Swedish research council (VR-M-2020-01652); Swedish e-Science Research Centre (SeRC); EU/Horizon 2020 no. 945539 (HBP SGA3); KTH Digital Futures. The simulations were enabled by resources provided by the Swedish National Infrastructure for Computing (SNIC) at PDC KTH partially funded by the Swedish Research Council through grant agreement no. 2018-05973. We acknowledge the use of Fenix Infrastructure resources, which are partially funded from the European Union's Horizon 2020 research and innovation programme through the ICEI project under the grant agreement No. 800858. Conclusions and future works Synapses are critical when investigating microcircuit functions and dynamics, therefore it is necessary to have a computationally efficient and accurate framework to model them. Here we are improving such a pipeline using morphologically detailed neurons. Our method is generic and hence applicable to any brain region. We are working on the integration of these models into large scale networks [1] as part of our ongoing effort to create detailed simulations of the entire striatum. We optimise the parameters of a Tsodyks-Markram model [3] to match and reproduce the different behaviours observed experimentally [2]. A comparison between the different synapse models (based on the different current models of NMDA and AMPA | poster |
A Novel Approach to Combat Antibiotic Resistance in Nosocomial Infections: Exploring the Synergistic Potential of Berberine and Glycerol Aziza Abugaliyeva, Annette Vincent, and Simon Faulkner Biological Sciences Program, Carnegie Mellon University Qatar Abstract Introduction Figure 1. Calibration curve for Berberine Chloride (BC) in Methanol. 10-50 ug/mL dilutions of BC were prepared using methanol. The absorbance was measured at 429 nm using Agilent 8453 UV-Vis spectrophotometer. Conclusions and Future Work References [1] Wojtyczka, R., Dziedzic, A., Kępa, M., Kubina, R., Kabała-Dzik, A., Mularz, T., & Idzik, D. (2014). Berberine Enhances the Antibacterial Activity of Selected Antibiotics against Coagulase-Negative Staphylococcus Strains in Vitro. Molecules, 19(5), 6583–6596 [2] Nguyen, H. T., Pham, T. N., Le, A. T., Thuy, N. T., Huy, T. Q., & Nguyen, T. T. T. (2022). Antibacterial activity of a berberine nanoformulation. Beilstein journal of nanotechnology, 13, 641–652. [3] AlMulla, M. (2023). Solubility Verification of Berberine Chloride (BC) in Natural Deep Eutectic Solvents (NADES) for the Development of Novel Antimicrobial Agents, CMUQ. [4] Battu, S. K., Repka, M. A., Maddineni, S., Chittiboyina, A. G., Avery, M. A., & Majumdar, S. (2010). Physicochemical characterization of berberine chloride: a perspective in the development of a solution dosage form for oral delivery. AAPS PharmSciTech, 11(3), 1466– 1475. • BC is an isoquinoline alkaloid extracted from plants. It exhibits weak antimicrobial activity against E. coli by itself [1]. • Early studies proposed certain approaches such as synergistic effects with other antimicrobial drugs to increase the effectiveness of BC [2]. • BC has limited solubility in water (1.96 ± 0.11 mg/mL) but it was found to readily dissolve in glycerol which stabilizes bacterial growth and prevents any damage to the cell membrane [3] [4]. Acknowledgments I want to express my immense gratitude to Dr. Simon Faulkner, Dr. Annette Vincent, and Ms. Maria Navarro for their guidance, assistance, and support throughout this research. Methods Gly 5% Gly 10% Gly 15% Gly LB+ LB+ LB+ Water LB Nosocomial infections, acquired during hospital treatment, are a significant challenge in healthcare settings. They are often caused by pathogens like E. coli, which have multiple virulence genes, making traditional treatments less effective due to antibiotic resistance. Berberine chloride (BC), a compound derived from the plant genus Berberis comprised of ~450-500 species, has shown antimicrobial activity against E. coli but its efficacy is limited when used alone. Combining BC with other antibiotics enhances its antimicrobial properties synergistically. Our research aims to improve BC's solubility in glycerol, enabling better dissolution in aqueous media without toxic co-solvents using Minimum inhibitory concentration (MIC) assay and solubility tests. This enhancement will optimize BC's therapeutic potential against nosocomial infections, providing valuable insights for more efficient treatment strategies. Sample Average rate (abs/hrs) STDEV control 0.309 0.006 (n=4) 5% Gly 0.259* 0.031 (n=4) 10% Gly 0.152 0.006 (n=2) 15% Gly 0.023# 0.015 (n=3) Table 1. Average growth rate of E. coli C600. Table 2. Solubility of BC in Gly, Water, and LB. y = 0.0147x + 0.0036 R2 = 0.9997 Results Figure 2. MIC assay to determine the effect of varying concentrations of Glycerol on E. coli C600. 0-70% glycerol was mixed with 10-3 diluted bacteria in a 96-well microplate incubated at 600 nm and 30OC for 20 hours in a Varioskan Lux machine. Solvent mass (mg) of BC added to 5 mL solvent Concentration of dissolved BC (mg/mL) Gly 101.6 14.45 Water 100.5 1.87 LB 100.7 0.06 Solvent mass (mg) of BC added to 5 mL solvent Concentration of dissolved BC (mg/mL) 5% Gly + LB 100.8 0.12 10% Gly + LB 100.2 0.11 15% Gly + LB 100.1 0.19 Table 3. Solubility of BC in 5, 10, and 15% Gly including LB. The solubility of BC in 5, 10, and 15% glycerol-LB mixture | poster |
BETWEEN UTOPIA AND DYSTOPIA LIES THE LAND OF KNOWLEDGE OR HOW TO STIMULATE SOCIAL DISCOURSE BASED ON FACTS RATHER THAN FEAR Dr. Luiza Bengtsson Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft luiza.bengtsson@mdc-berlin.de @bengtza @OOSP_ORIONPod PUBLIC DIALOG ON GENOME EDITING IN UK, GERMANY, SWEDEN & CZECHIA • 3-MONTH RESIDENCY IN MDC LABS, REFINING CONCEPT, PROOF OF CONCEPT EXPERIMENTS • ARTIST MEETS SCIENTISTS: MODERATED CLASH OF CULTURES • OPEN CALL: WINNER EMILIA TIKKA • ORION OPEN SCIENCE PROJECT: CO-CREATION EXPERIMENTS • EXHIBITIONS LESSONS LEARNED! | poster |
U.S. Environmental Protection Agency Office of Research and Development EPA www.epa.gov Thomas 2019 Bryant A. Chambers and Imran Shah Center for Computational Toxicology and Exposure, US EPA Constructing Unique Stress Signatures Identifying best performing stress signatures Stress signature activity within LINCS test set Conclusions and future directions Bryant A. Chambers l chambers.bryant@epa.gov l 919.541.4268 Finding a test set within the Library of Integrated Network- Based Cellular Signatures (LINCS) SR Pathway Accuracy in 1st Accuracy by 2nd Accuracy by 3rd DDR-400 75% 100% 100% UPR-050 100% 100% 100% HSR-GO 57% 100% 100% HPX-WINT 100% 100% 100% MTL – 200 33% 33% 67% OSR – 200 25% 50% 50% Mean Accuracy 72% 88% 91% Background and Hypothesis Key Conclusions • SRP can be accurately identified using gene signatures in transcriptomic data. • Distinct signals arise from well known chemical agents. • Consensus SRP signatures perform better than published signatures. • Consensus SRP signatures activity identified in LINCS data test set. Future Directions • Concentration-response analysis to estimate benchmark concentrations (BMC) • The lack of available methods to test non-specific chemical points of departure can be expanded to include a new approach method derived from general stress response transcriptomic assays. • Tissue and cell specificity • Expression of stress response systems is partially dependent on cell and tissue type; as such, a deeper understanding of tissue dependency must be achieved. SRP Abbreviation Reference Chemical DNA Damage Response DDR Benzo(a)pyrene Glycinamide Lasicoarpine Methylmethanesulfonate Unfolded Protein Response UPR Brefeldin A Thapsigargin Tunicamycin Heat Shock Response HSR Geldanamycin Heat with recovery Radicicol Response to Hypoxia HPX Oxygen VU-0418946-1 VU-0418946-2 Metal Response MTL Silver Nitrate Zinc Oxidative Stress Response OSR Hydrogen peroxide Tert-butyl hydrogen peroxide A) Activity of SRPs in training data set B) Performance of SRP signatures against randomized null C) Performance of SRP signatures against published signatures Accuracy of Signatures in training data set Highly gene-overlapped published signatures 𝑮𝑮𝑮𝑮𝑮𝑮𝑮𝑮𝑨𝑨𝑨𝑨𝑨𝑨𝑨𝑨𝑨𝑨𝑨𝑨𝑨𝑨𝑨𝑨𝑨𝑨𝑨𝑨𝑨𝑨 𝑨𝑨𝑨𝑨𝑨𝑨𝑨𝑨𝑨𝑨𝑨𝑨𝑨𝑨𝑨𝑨𝑨𝑨𝑨𝑨 Unique consensus gene space Consensus Signature Set Construction • Identified 48 relevant published signatures by inclusion of ~ key genes • Use “Wisdom of the Crowd” to score gene inclusion • Frequency based (f): 𝑓𝑓𝑖𝑖𝑖𝑖𝑔𝑔𝑔𝑔𝑔𝑔𝑔𝑔𝑔𝑔−𝑓𝑓𝑜𝑜𝑜𝑜𝑜𝑜𝑔𝑔𝑔𝑔𝑔𝑔𝑔𝑔𝑔𝑔 𝑓𝑓𝑖𝑖𝑖𝑖𝑔𝑔𝑔𝑔𝑔𝑔𝑔𝑔𝑔𝑔+ 𝑓𝑓𝑜𝑜𝑜𝑜𝑜𝑜𝑔𝑔𝑔𝑔𝑔𝑔𝑔𝑔𝑔𝑔 Reference Chemicals • 49 reference chemicals were identified in the literature • 2000 GSEs found in the Gene Expression Omnibus matching • Only 35 GSEs proved sufficiently annotated DDR UPR HSR HXP MTL OSR Highly Probable Library of Integrated Network-Based Cellular Signatures (LINCS) • Searched all LINCS chemicals in pub med against stress systems • 7 terms (e.g., ‘DNA damage’, ‘er stress’, unfolded protein response’) • Totaled 32,679 searches • Pairwise mutual information (PMI) score calculated for each chemical • 𝑃𝑃𝑃𝑃𝑃𝑃𝑐𝑐𝑐𝑐𝑐𝑐𝑐𝑐𝑐𝑐𝑐𝑐𝑐𝑐𝑐, 𝑠𝑠𝑠𝑠𝑠𝑠𝑠𝑠𝑠𝑠𝑠𝑠= log 𝐹𝐹(𝑐𝑐𝑐𝑐𝑐𝑐𝑐𝑐𝑐𝑐𝑐𝑐𝑐𝑐𝑐,𝑠𝑠𝑠𝑠𝑠𝑠𝑠𝑠𝑠𝑠𝑠𝑠) 𝐹𝐹𝑐𝑐𝑐𝑐𝑐𝑐𝑐𝐹𝐹(𝑠𝑠𝑠𝑠𝑠𝑠𝑠𝑠𝑠𝑠𝑠𝑠) • Filtered to chemical with PMI > 1 and references >200 yielding a subset of 90 perturbagens • Pulled first 500 abstracts for each match and validated 68 high probability chemicals by review • Transcriptomic Dataset includes: • 11000 Profiles • 81 cell types Concentration response for HSR chemical geldanamycin Activity of SRP consensus signatures was evaluated in 68 “highly probable” chemicals in the LINCs database. Cell type aggregated data indicates broad applicability • 100% of chemicals showed activity in at least one cell line • 92% of HSR and 88% of UPR in cell aggregated data • 30/68 chemical have concentration response • Tissue and cell type is IMPORTANT DDR UPR HSR HPX MTL OSR References Ankley (2010) Environmental Toxicology and Chemistry, 29: 730-741 Simmons (2009)Toxicological Sciences 111(2,) 202–225 Judson (20 | poster |
Localizing Stellar Activity on Low Mass Stars with the Transiting Exoplanet Survey Satellite 2. Sample Demographics 1. Stellar Activity Julie Moquin1,2, Jordan Ealy1,3, Joshua Schlieder1 1Goddard Space Flight Center, 2Rice University, 3University of Maryland College Park Fig 1. The above figure depicts how a flare is created through magnetic field reconnection. ●Low-mass stars often have high flaring rates ●Caused by a sudden magnetic reconnection ●Usually associated with star spots [Ikuta et al. 2023] ●Spot modulation is caused by a decrease in optical flux from an increase in star spot coverage. ●BANYAN Moving Group Stars [Gagné et al. 2018] ○Stars from β Pictoris Moving Group (βPMG), AB Doradus Moving Group (ABDMG), Tucana-Horologium Association (THA), Columba Association (COL), Carina Moving Group (CAR) ●Sample optimization removed the field stars as they do not have detectable spot modulation. ●We used Lightkurve [Lightkurve Collaboration 2018] to examine the light curves for possible contamination. Credit: NASA/ESA/G. Baco 3. Data Analysis Phase Folding the Light Curves Fig 5. Phase-folded light curve with an offset. Using an offset makes it easier to see where the flares are located in the phase-folded graph. Fig 4. (a) a TESS light curve. (b) The same light curve, but phase-folded. ●To phase-fold a light curve, the light curve is folded based on the star's rotation rate which we estimate using a Lomb-Scargle periodogram ●Phase-folding aids with visualizing in which area of the period the flares are located Localizing Stellar Activity on Low-Mass Stars with the Transiting Exoplanet Survey Satellite Julie Moquin Jordan Ealy Joshua Schlieder Credit: NASA/ESA/G. Bacon (STScI) βPMG (~24 Myr§) ABDMG (~149 Myr§) THA (~45 Myr§) COL (~42 Myr§) CAR (~45 Myr§) 8 4 4 11 1 33.7% 17.1% 27.1% 1.0% 21.1% Fig 3. The outer donut chart depicts the percentage of light curves used from each moving group. The inner donut chart depicts the number of sources used from each moving group. The color blocks are different shapes as some stars had multiple sectors of observation. The sectors were treated individually to maintain observation integrity. ●Trends in flare rates and spot modulation can provide a means to “localize” on the rotation phase where flares occur more frequently and whether they are associated with active regions (ie star spots). We selected our sample to include young stars. Fig 2. Spot modulation is seen in light curves as the dips in flux. For young stars, other sources of variability can cause aperiodic brightness changes and lead to complex, non-sinusoidal morphologies. The zoom in shows the morphology of a flare and the spot modulation. Future Work Localizing the Flares ●Inflection Point Sectioning ●Rigorous Statistics on Flare Distribution Results ●Continuum localization ●To validate our methods, we did an initial survey on 44 light curves with consistent, sinusoidal spot modulation. We plotted the start location of flares along the rotation phase. The phase-folded light curves were co-aligned in phase space using their minima. We used AltaiPony [Ilin et al. 2021] to detect the flares on all the light curves. A flare is detected if there is enough data 3σ above the midline. The midline is found by detrending the light curve, which removes the periodic signal from the light curve. Identifying the Flares Fig 6. The flares are highlighted in blue. This is useful for making sure that all flares are identified properly and allows for localization analysis by eye. Scan me for abstract, contact information, and references! Fig 7. All panels are aligned in phase and colored by effective temperature of the flaring star. (a) Phase-folded light curves. Offset peaks show varied spot coverage. (b) Distribution of the flare start times. (c) Cumulative histogram of the flare density with a kernel density estimate line. We see a higher density of flares closer to the minimum. 1 2 3 4 5 (a) (b) 6 ●This histogram hints that there are more flares around the minima of | poster |
Planetary Nebulae in the Solar Neighbourhood: Statistics and Luminosity Function David J. Frew(1) and Quentin A. Parker(1,2) 1. Department of Physics, Macquarie University. 2. Anglo-Australian Observatory. Abstract: Recent Hα+[NII] surveys such as the AAO/ UKST Survey and SHASSA have been used to discover a number of new, large, nearby planetary nebulae (PNe). As a result, we have been able to compile a relatively complete census of PNe in the solar neighbourhood, based in part on a new Hα surface brightness – radius relation. We observe an inflection point (or dip) in the cumulative PNLF, seen in both [OIII] and Hβ. Our estimate of the PN formation rate is in quantitative agreement with the white dwarf birthrate. The number of Galactic PNe is estimated to be at least 30,000 and possibly as high as 50,000. Our new PN sample has increased the number of old objects and has allowed the faint end of the PN luminosity function (PNLF) to be seen clearly (see Figure 4). Especially noticeable are the inflection points (or ‘dips’) in the PNLF at M5007 ≈+0.3 and MHβ ≈+2.6. We attribute this to the rapid decline in luminosity of the central star as it starts descending the WD cooling track. While not unexpected, our PNLF’s show this feature clearly for the first time. We also aim to improve the statistics of the total space density and birthrate of PNe, as these parameters are critically dependent on the adopted statistical distance scale for old PNe (Ishida & Weinberger 1987; Pottasch 1996). Allowing for some incompleteness, a preliminary estimate of the PN birthrate is 1.2 ± 0.5 x 10-12 pc-3yr-1, which agrees with the white dwarf birthrate of 1.0 ± 0.25 x 10-12 pc-3yr-1 determined by Liebert et al. (2005). The total population of PNe in the Galaxy is estimated to be >30,000. Planetary nebulae (PNe) are some of the most beautiful and photogenic non-stellar objects in the heavens, and are a “key tool” to understanding the evolution of low- and intermediate-mass stars. The main goals of this study are to provide the most accurate census of nearby PNe in the solar neighbourhood yet compiled, and to refine the statistical distance scale for old PNe. A key adjunct to this project is the AAO/UKST Hα Survey (Parker et al. 2005a). This is a high-resolution, narrow-band Hα+[NII] survey of the Southern Galactic Plane and the Magellanic Clouds using a large, high- quality interference filter on the 1.2-m UKST. The survey comprises narrowband Hα and broadband short-red (SR) photographic images which have been digitized by the SuperCOSMOS measuring machine at ROE. The survey has led directly to the discovery of nearly 1000 new Galactic PNe, mostly of very low surface brightness (see figures 2 & 3). The Macquarie/ AAO/ Strasbourg/ Hα Catalogue (MASH) is a major product of this survey (Parker et al. 2003, 2005b), and includes a good many examples of very large angular diameter, up to nearly 30 arcminutes. Slit spectra have been obtained on a variety of telescopes for all MASH PNe candidates, and we have obtained additional narrow-band imaging to get additional morphological data. We have produced an accurate database of fluxes in the main emission lines for these nearby, highly- evolved PNe. Data has come from our spectroscopy and imaging plus Hα fluxes from the SHASSA and VTSS sky surveys (Frew & Parker in prep.) from which other line fluxes can be bootstrapped via our spectroscopic information. We have also obtained Hα, Hβ, [OIII], and [NII] integrated fluxes for a number of northern PNe using the WHAM Fabry-Perot interferometer (Madsen & Frew, in prep.) D.J.F. has also examined SHASSA images (Gaustad et al. 2001) and has found several new large candidate PNe. Additional WHAM data is being used to determine the nature of several unusual objects (Sh 2-174, DeHt 5, RE 1738+665, Ton 320, PHL 932, Hewett 1, etc), showing that some of these objects are examples of ionized ISM, and are not true PNe. As a result, we have compiled a ‘clean’, statistically-s | poster |
U.S. Environmental Protection Agency Office of Research and Development EPA www.epa.gov Building a compendium of expert driven read-across cases to facilitate an analysis of the contribution that different similarity contexts play in read-across G Patlewicz1*, Amanda Ross2, HC Bledsoe2, Janielle Vidal2, Louis Groff1, Brett Hagan1,3, Imran Shah1 1 CCTE, U.S. EPA, RTP, NC, USA, 2ICF Corporation, Reston, VA, USA,3ORAU, Oak Ridge, TN, USA BACKGROUND STRUCTURAL SIMILARITY EVALUATION Grace Patlewicz l Patlewicz.grace@epa.gov l ORCID: 0000-0003-3863-9689 l 919-541-1540 CONCLUSIONS Disclaimer: The views expressed are those of the authors and do not necessarily reflect the views or policies of the US EPA. • 82 Read-across examples cases were compiled from the three main sources. • There were 22 unique decision contexts when aggregated by NAMs, technical guidance or regulatory purposes. • Of the 82 examples, 68 captured regulatory purposes, the remainder were relatively evenly split between efforts to improve guidance or evaluate the utility of NAMs to substantiate read-across justifications. METABOLIC SIMILARITY EVALUATION CLASSYFIRE METHODS The 82 read-across example cases were characterised by 497 individual substances of which 468 could be mapped to a discrete organic structure by way of SMILES To gain a perspective of the chemical diversity across these 468 substances, the chemistry ontology ClassyFire was used to assign structures into their respective chemical class. Some ~63% of the substances were members of either the “Benzene and substituted derivatives” class (25%), the “Fatty Acyls” class (14%), the “Organooxygen compounds” class (12%) or the “Carboxylic acids and derivatives” class (12%). A t-SNE plot based on Morgan chemical fingerprints shows the chemical landscape and is colour coded using a subset of the most populist chemical subclasses. Across the 82 examples, there were 77 different evidence streams characterising the basis for identifying and evaluating the source analogues in each case. The first component of the evidence stream characterising the primary means of identifying candidate source analogues was a structural one in 72 cases, and metabolism in 4 cases. There were 13 different approaches by which analogues were identified. The barplot highlights the main tools and approaches. The OECD Toolbox, DSSTox (within the EPA CompTox Chemicals Dashboard), the NIH’s structure searching tool within ChemIDPlus or some combination of these tools were most common in terms of identifying structural analogues. However by far the most common means of identifying analogues was to look for common scaffolds based on functional groups. • The pairwise Jaccard similarities were computed within each read-across example to explore how structurally similar the target and source analogues were amongst themselves. • The median of the distribution of median values for each case study was determined to be 0.34. (see Fig a) • There was a large degree of variation in pairwise similarities within each case study (See Fig b) Read-across is a data-gap filling technique utilised to predict the toxicity of a target chemical using data from similar analogues. Read-across is predominantly performed as part of an expert-driven assessment which can impeded broad acceptance. Data-driven approaches such as Generalised Read-Across (GenRA) offer scope to generate reproducible read-across predictions where uncertainties and performance are quantified. A key issue is how to reconcile an expert-driven approach with a data driven approach both in terms of how analogues are identified and evaluated as well as how the read-across prediction is derived. An important component of analogue identification and selection is in understanding the contribution that different similarity contexts play, i.e. does structural similarity play a larger role in analogue selection compared with metabolism similarity. This study aimed to explore some of these conside | poster |
Unveiling the ICM properties of clusters missed by baryon-selected samples ● Past samples were selected by an observable with covariance with the quantity of interest. These are biased. ● Past works shows that samples non-ICM selected have properties rare (or unique) in ICM-selected samples: – (low) pressure profiles: JKCS041 (z=1.803, SA+2023), IDCSJ1426.5+3508 (z=1.75, SA+21), CL2015 (z=0.05, SA+21). – (variety) Scatter in LX-M, T-M, LX-YX for σv-selected clusters (SA+17, SA+17a,b, SA+19) – (variety) Scatter in LX-M for richness-selected clusters (SA+11) – (variety) Distribution of central X-ray brightness (LX- vs SZ- vs σv-selected, SA+24) ● Present: the baryon selection can be entirely removed by using weak-lensing selected clusters. Performed high- quality X-ray and SZ follow-up of a very few such clusters. These clusters have properties rare (weak and variegate for their mass) in ICM-selected samples (paper submitted). ● AtLAST allows us to unveil the properties of Euclid weak-lensing selected clusters, many of which are weak/faint for their mass (this is one of the AtLAST science cases). Active actions in Euclid consortium (to provide reliable targets). Pilot observations already started with NIKA2, others planned during the MISTRAL commissioning. Stefano Andreon – INAF-OA Brera, Milan, Italy | poster |
Exp 359 – Maldives Monsoon and sea level Luca Lanci, DISPEA, Università di Urbino • Dating the sediment (magnetic stratigraphy) • Magnetic stratigraphy Site U1467 drilled in the Maldives platform (Indian Ocean) during Exp. 359, gives a precise record of geomagnetic reversals of the early Pliocene from approximately 5.3 Ma to 3.1 Ma providing a detailed age model in an interval where the biostratigraphic record is scarce. • Searching for bottom currents (anisotropy of magnetic susceptibility) • We use the anisotropy of isothermal remanent magnetization to investigate the statistical orientation of fine magnetic particles and provide data on the strength and direction of bottom currents during the early Pliocene. The strength of bottom currents recorded by the AIRM, shows a prominent increase at the top of Chron C3n.1n (about 4.2 Ma), and the current direction (NE - SW) is consistent with that of modern instrumental measurements. • Why does it matters? • The South Asian Monson is one of the most intense annually recurring climatic elements and of immense importance in supplying moisture to the Indian subcontinent thus affecting human population and vegetation. The seasonal precipitation change is one of the elements most noticed on land, whereas the reversal of the wind regime is the dominating driver of circulation in the central and northern Indian Ocean. Wind-induced currents are an important factor controlling the sedimentation in the Maldives archipelago where they regulate sediment transport from the atoll to the deeper part of the platform as well as the geometry of the sedimentary bodies. The onset of these current-driven drift deposits has been related to the increase of monsoon activity starting in the middle Miocene. , | poster |
The role of gas and dark matter in the dissociative collision of galaxy cluster Abell 2034 Micheli Trindade Moura, Rubens E. G. Machado Universidade Tecnol´ogica Federal do Paran´a (UTFPR), Curitiba, Brazil micheli trindade.moura@hotmail.com Galaxy Cluster Formation (GCF) 2021 Abstract: Collisions between galaxy clusters are a frequent sce- nario in the hierarchical model of structures. Dissociative collisions provide an extreme environment of interaction between clusters of galaxies, where the properties of dark matter (DM) in relation to baryonic matter become evident. Investigating dissociative scenar- ios allows a deeper understanding of the behavior and dynamics of baryonic and non-baryonic matter in this context of collision. Abell 2034 (z = 0.114) is a bimodal system composed of a north and a south substructure, it has dissociative features observed in X- rays and gravitational lensing. Using N-body hydrodynamic sim- ulations, we present a theoretical study based on the dissociative collision of A2034, aiming to explore the effect that different rela- tive concentrations between the clusters generate on the dynamics of the system. We investigated the relationship of the central density ratios with different levels of dissociation, where we analyzed nine models with different concentrations of the two components: intra- cluster gas and DM halo for each substructure. We found different degrees of dissociation that were quantified by the relative distance between the X-ray emission peak and the dark matter peaks. We found that the ratio of the gas central densities is more decisive than the ratio of dark matter central densities, in determining the level of dissociation for the parameters of this collision. 1 Introduction Dissociative systems are a peculiarity of collisions between galaxy clusters, and are known in the literature since 2006 with the Bullet Cluster (Clowe et al., 2006). Abell 2034 (A2034) is a cluster at lo- cal Universe (z = 0.114) that has dissociative features. The A2034 is composed of two substructures: A2034N and A2034S. The main points about recent developments of the A2034 in the literature are: • The distance between the X-ray emission peak and the south dark matter peak is around 348 kpc, where the distance between both total mass peaks is ∼720 kpc (Monteiro-Oliveira et al., 2018). Implying in a clearly dissociative system, with gas approximately in the middle of two DM peaks. • This merger system has been observed by X-ray satellites since ROSAT (David et al., 1999), and more recently by XMM- Newton (Okabe & Umetsu, 2008) and Chandra (Kempner et al., 2003; Owers et al., 2014). • More recently mass reconstruction are performed by weak gravita- tional lensing method in 2018 by Monteiro-Oliveira et al. (2018). Numerical simulations were developed motivated by the analysis of X-rays and gravitational lensing, leading to a proposed scenario for this collision, where we observed the system at 0.26 Gyr after the central passage (Moura et al., 2021). From this numerical scenario, we carry out a theoretical exploration of the effect that different gas and DM concentrations cause in the dissociation of the A2034 merger system. Figure 1. Gas scale length variations, for north (200, 300 and 400 kpc) and south (300, 400 and 500 kpc) substructures. The first row shows gas density maps with contours representing total mass. The second row shows projected temperature maps for each model. The third row shows X-rays mocks from counts/pixel and contour curves of the total mass. 2 Simulation setup We aim to investigate the dissociative collision of Abell 2034 using N-body hydrodynamic simulations. To simulate this merger con- text, we set up two spherical galaxy clusters. The code employed and details about the simulation are: • We adopt the Gadget-2 code (Springel, 2005), which uses smoothed particle hydrodynamic (SPH); • The initial conditions are composed of 106 gas particles and 106 DM particles for each cluster; • The | poster |
Standardizing Documentation of FITS Headers Although the FITS file format[1] can be self-documenting, human intervention is often needed to read the headers to write the necessary transformations to make a given instrument team’s data compatible with our preferred analysis package. External documentation may be needed to determine what the values are of coded values or unfamiliar acronyms. Different communities have interpreted keywords slightly differently. This has resulted in ambiguous fields such as DATE-OBS, which could be either the start or mid-point of an observation.[2] Conventions for placing units and additional information within the comments of a FITS card exist, but they require re-writing the FITS file. This operation can be quite costly for large archives, and should not be taken lightly when dealing with issues of digital preservation. We present what we believe is needed for a machine-actionable external file describing a given collection of FITS files. We seek comments from data producers, archives, and those writing software to help develop a single, useful, implementable standard. http://virtualsolar.org/ 218.48 J.A. Hourclé NASA-GSFC (Wyle) joseph.a.hourcle@nasa.gov Goal: Create a documentation standard that : • Does not require modifying existing FITS files. • Is machine-readable. • Can be used by software developers to integrate new missions & instruments with minimal effort. The documentation should: • Identify which keywords are using a registered FITS standard and which are discipline, mission, instrument, or processing specific. • Provide units if not explicitly given • Identify range of possible values • Provide expansion / explanation of enumerations • Provide free text to describe how to interpret coded values (eg, SDO ‘QUALITY’), or for additional details. • Identify the authoritative value from a group of similar values. (thus identifying which values are derived, and have more error) References: [1] Pence, et.al. 2010, “Definition of the Flexible Image Transport System (FITS), version 3.0”, http://dx.doi.org/10.1051/0004-6361/201015362 [2] Rots, et.al, (in preparation), “Representations of Time Coordinates in FITS Time and Relative Dimension in Space (V1.0) “, http://hea-www.cfa.harvard.edu/~arots/TimeWCS/ [3] Derriere, et.al, “Vocabularies in the Virtual Observatory, Version 1.19”, http://www.ivoa.net/documents/latest/Vocabularies.html [4] W3C, “Simple Knowledge Organization System“, http://www.w3.org/2004/02/skos/ [5] NASA, “Fits Keyword Dictionaries”, http://fits.gsfc.nasa.gov/fits_dictionary.html [6] NASA HEASARC, (untitled) http://heasarc.gsfc.nasa.gov/docs/fcg/standard_dict.html [7] NOAO, “NOAO FITS Keyword Dictionary: Version 1.0” http://iraf.noao.edu/iraf/web/projects/ccdmosaic/imagedef/fitsdic.html [8] Shimojo, “The List of SOLAR-B”Hinode” Mission-Wide FITS Keywords”, http://hinode.nao.ac.jp/sbsc/SB_MW_Key13.pdf [9] W3C, “SKOS Simple Knowledge Organization System Primer”, http://www.w3.org/TR/skos-primer/ FITS ‘Keyword Dictionaries’ Although there are many ways of documenting FITS keywords, a number of missions use a ‘keyword dictionary’.[5] The structure varies, as there is no single standard for these documents. For example: [6,7,8] KEYWORD: BITPIX REFERENCE: FITS Standard STATUS: manditory HDU: any VALUE: integer RANGE: -64,-32,8,16,32 COMMENT: bits per data value DEFINITION: The value field shall contain an integer. The absolute value is used in computing the sizes of data structures. It shall specify the number of bits that represent a data value. NAME: Image.naxis[i] KEYWORD: NAXIS%d DEFAULT: none INDEX: 1-9 HDU: primary & extension VALUE: %d UNITS: COMMENT: Number of pixels along axis EXAMPLE: 2048 DESCRIPTION: Required FITS format keywords. Header Keyword: NOAA_NUM Format : Integer Unit/Option : - Category : SOLAR-B Data Source : Chief observer or Proposer of the observation Sample : 11345 Description : The NOAA number of the active region. Note : If the target region doe | poster |
Motivation und Zielsetzung Methode und Vorgehensweise Status und nächste Schritte Betreuung Porsche: Betreuung Hochschule: 1. Jahr 2. Jahr 3. Jahr AI Methods in Procurement - Simulation workflow concept - • Case study in the automotive industry with real business data (confidential) • Interesting master thesis project in the newly founded Car I am Digital (CARIAD) organization within the Volkswagen Group • Identify and create further potentials for cost savings and workflow improvements • Provide better data for decision-making • Create tangible added value through AI also for your organization 20210606_SDS_DC_Simulation_Poster_How many buyers does it take to build a car_Mannheim_Spreitzenbarth_Jan.pdf.pptx 2/3 Jan Martin Spreitzenbarth, University of Mannheim Value function: Max periods ௐ௧ொ ଵିௐ௧் (1) Key performance indicators to be measured may include maverick buying, unmet expectations, attitude towards procurement, idle time and excessive workload, which could answer the research question and prepositions. Motivation Outlook Method Looking forward to further ideas to improve the simulation concept. Looking forward to further ideas to improve the simulation concept. Working prototype for a value function of procurement The conceptual model is iteratively improved through feedback 20210606_SDS_DC_Simulation_Poster_How many buyers does it take to build a car_Mannheim_Spreitzenbarth_Jan.pdf.pptx 1/3 Jan Martin Spreitzenbarth, University of Mannheim Research question: How to solve the organizational sizing problem by maximizing procurement value creation? Preposition I: The sizing problem can be solved by optimizing the value function Preposition II: Simulation shows value of flexibility, e.g., by lean and agile principles Theoretical background KPIs to measure the results Model and train the agents Motivation Outlook Method Simulation of a dynamic system with feedback loops Optimize value creation of procurement through simulation as a work system Design a prototype of a simulation-based procurement work flow system. Design a prototype of a simulation-based procurement work flow system. • Building a working prototype, which can be improved with more data and feedback by the buyers • Looking forward to your feedback to improve the concept 3. Jahr Beschaffungsstrategie Prof. Dr. Heiner Stuckenschmidt 20210606_SDS_DC_Simulation_Poster_How many buyers does it take to build a car_Mannheim_Spreitzenbarth_Jan.pdf.pptx 3/3 Jan Martin Spreitzenbarth, University of Mannheim Theoretical and managerial implications • Value: Organizational sizing can be solved by a value function • Organization: Indirect business functions can be strengthened • Results: The value of organizational flexibility can be shown Limitations, future outlook and questions for discussion • Method: It’s generally easy to challenge the modeling results due to necessary abstraction…what do you suggest to focus on in the design of this study? • Novelty: Which relevant works, theories, and methods would you recommend to investigate further? • Concept: Where do you see shortcomings? What would you do differently? What do you like about it and see potential contributions and advantages? Motivation Outlook Method Thanks for your attention. Looking forward to a good discussion with you! Thanks for your attention. Looking forward to a good discussion with you! Now fun part with implications, questions, and discussion! Looking forward to ways to improve the concept Hr. Joachim Scharnagl Beschaffungsstrategie Jan Martin Spreitzenbarth BCX - Beschaffung Smart Mobility | poster |
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