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True statement about tongue epithelium are all except?
|
Posterior 1/3 tongue is endodermal in origin . Tongue connective tissue and muscles- mesodermal in origin , connective tissue is derived from pharyngeal arches 1,2 and 3.
| 4
|
At beginning -Endodermal (whole tongue)
|
Any External opening lined by Surface Ectoderm - Ant.2/3 of tongue
|
At Sulcus Terminalis- Ectoderm and Endodermal junction
|
Posterior 1/3rd - Mesodermal
|
Anatomy
|
Pharyngeal Arches
|
dfd50d1a-d1c7-47af-937d-a554b5141a01
|
multi
|
Which of the following is used for day care surgery?
|
Drugs used in day care surgery Dr Desflurane Manmohan Midazolam Singh Sevoflurane Is Isoflurane A Alfentanyl Prime Propofol- mc drug used in day care surgery Minister Mivacurium Ketamine causes dissociative anesthesia Thiopentone is shoest acting due to redistrubution Etomidate causes adrenal supression
| 3
|
Ketamine
|
Thiopentone
|
Propofol
|
Etomidate Drugs used in day care surgery
|
Pharmacology
|
FMGE 2019
|
f679cf27-eafc-4051-b9f8-7259b64ac8e8
|
single
|
Which of the following is the most potent 2nd generation antihistamine?
|
Desloratidine, metabolite of loratadine is the most potent 2nd generation antihistamine.
| 2
|
Astemizole
|
Desloratadine
|
Promethozine
|
Fexofenadine
|
Pharmacology
| null |
326d4d56-a54a-4f92-b1e2-5a4713c3e459
|
single
|
External manifestation of genome is -
|
Ans. is 'b' i.e., Phenotype* To explain these terms, let us have a simple example, which we have learnt in our school.* A sweet pea plant can either grow tall or short. The plant grows tall if the plant has TT or Tt and the plant remains dwarf if the plant has tt. In this example, plant being tall and plant being short are the two phenotypes. Hence phenotypes are the external manifestations of a genome. Genotypes are genetic expressions of a trait. Just by looking at something, if we can comment whether the plant can grow tall or if the plant has to remain dwarf is called as genotypes. So there are three genotypes - TT, Tt, tt. What are alleles? T is one allele and t is another allele. So alleles are alternating forms of the same gene.* Genotype is the genetic expression of a trait* Phenotype is the physical expression of a trait* Alleles are alternating forms of the same gene - in the sense they differ by a few nucleotide sequences so that aminoacid sequences of the polypeptide chain gets affected minimally - so that the function of the protein gets affected either qualitatively or quantitatively.* Polymorphism is presence of multiple alleles at a single locus giving rise to multiple phenotypes, provided the prevalence of the alleles in a general population is more than 1%# For example, hair colour - we do not say only black hair is normal, various shades of brown and even white hair in a blonde person is normal. This is because of the presence of multiple alleles - an allele produces black pigment, many alleles to produces various shades of brown and then an allele which does not produce pigment - causing blonde hair.# In this example the last allele which has failed to produce the respective protein should be considered as a defective allele. But we consider it as a normal allele based on prevalence. As prevalence of the allele which can not produce the pigment is more than 1% in the general population, we call it as a normal allele.
| 2
|
Genotype
|
Phenotype
|
Allele
|
Polymorphism
|
Biochemistry
|
Molecular Genetics
|
8c17d6ae-5dc1-4ea5-9430-a325f4b5fd23
|
multi
|
Which of the following anaesthetic agent does not cause hypotension on injection ?
|
Ketamine causes increase in BP.
| 1
|
Ketamine
|
Propofol
|
Halothane
|
Thiopentone
|
Anaesthesia
| null |
8720ef92-f9db-4bd8-8d6e-65670fad251c
|
single
|
In Peripaum cardiomyopathy, cardiac failure occurs at:-
|
Diagnostic criteria for Peripaum cardiomyopathy - A) Development of cardiac failure in the last month of pregnancy or within 5 months after delivery. B) Absence of an identifiable cause for the cardiac failure. C) Absence of recognizable hea disease prior to the last month pf pregnancy D) Left ventricular systolic dysfunction demonstrated by classic echocardiographic criteria, such as depressed ejection fraction along with a dilated left ventricle
| 4
|
Within 7 days after delivery.
|
Within 6 weeks after delivery.
|
Within 24 months after delivery.
|
Within 5 months after delivery.
|
Gynaecology & Obstetrics
|
NEET 2018
|
a91f5e09-0811-4845-87cd-d766ab11195f
|
single
|
Drug used for d-TC reversal is
|
Reversal of d tubocuraine was done by neostigmine.
| 4
|
Atropine
|
Atracurium
|
Diazepam
|
Neostigmine
|
Anaesthesia
|
Muscle relaxants
|
e6a60e80-c50a-4d69-8a40-d7cb73604caf
|
single
|
A young adult presented with diminished vision. On examination he has anterior uveitis, vitritis, focal necrotizing granuloma, macular spot. What is the most probable diagnosis?
|
Focal necrotizing granuloma in this question suggests that it may be a case of ocular toxoplasmosis.
| 4
|
Proteus syndrome
|
White dot syndrome
|
Multifocal choroiditis
|
Ocular toxoplasmosis
|
Ophthalmology
| null |
588b3f85-babe-4dd3-910f-902d38cf9efb
|
single
|
Excision of the hyoid bone is done in
| null | 3
|
Branchial cyst
|
Branchial fistula
|
Thyroglossal cyst
|
Sublingual dermoids
|
Surgery
| null |
ca6c88ed-5a97-4b5d-942f-e836ecd3a235
|
single
|
CSF glucose level is -
| null | 2
|
Half the plasma glucose
|
2/3 of plasma glucose
|
1/3 of plasma glucose
|
Same as plasma glucose
|
Medicine
| null |
f46ef2fc-db7c-48c8-b477-2ce21f2b0ec1
|
single
|
Rapid cycling is associated with which illness:
|
Ans. C. Bipolar disorderBipolar disorder involves extremes of both high and low moods and a range of other symptoms. In rapid cycling, moods change quickly, with at least 4 distinct mood episodes per year.
| 3
|
Substance abuse
|
Schizophrenia
|
Bipolar Disorder
|
Panic disorder
|
Psychiatry
|
Mood Disorders
|
a5f14e18-3470-49df-bf06-9aa54cf40abd
|
single
|
Daily water requirement in child weighing 30 kgs, height 123 m and BSA of 1 m2 is
|
For calculating the minimum amount of fluid per day, a formula based on body weight is recommended: 1500 ml is the minimum water intake with 15ml fluid per kg to be added for the actual weight minus 20kg. Reference: GHAI Essential pediatrics, 8th edition
| 2
|
1300 ml
|
1700 ml
|
2000 ml
|
2500 ml
|
Pediatrics
|
Fluid and electrolytes
|
302d1538-f9f9-4e63-81e1-0b985e1609c3
|
single
|
Good diabetic control is said to be present when glycosylated hemoglobin is
| null | 1
|
7-9%
|
>13%
|
10-12%
|
3-4%
|
Medicine
| null |
12f791fb-ca25-426f-89c8-62a0984a7b86
|
single
|
Not true about Antro choanal polyp
|
Best examined with posterior Rhinoscopy.
| 1
|
Best examined with Anterior Rhinoscopy
|
Less recurrence rate
|
Seen in young individuals
|
Usually unilateral
|
ENT
| null |
f2901b14-5b1b-4c1a-9105-4ee620574ff6
|
multi
|
A testicular tumor marker is -
|
Ans. is 'a' i.e., a-Fetoproteins
| 1
|
a-Fetoprotein
|
Ectopic hormones
|
CEA
|
Testosterone
|
Pathology
| null |
144d29b6-2779-4040-ab93-c25cf334df43
|
single
|
Ramu age 10 years, present with itching in his eye, foreign body sensation and ropy discharge since several months. These symptoms are more prominent in summer. Most probable diagnosis is -
|
Ans. (a) Vernal conjunctivitisRef: Parson's 21/e, p. 178Age 10 years (Male child), with Itching, foreign body sensation, Ropy discharge (characteristic of spring catarrh) and exacerbation during summer (characteristic of spring catarrh) is diagnostic for VKC.
| 1
|
Vernal conjunctivitis
|
Fungal keratoconjunctivitis
|
Viral conjunctivitis
|
Trachoma
|
Ophthalmology
|
Conjuctiva
|
b211a7fe-1a8f-48a5-9951-b2558963e2c6
|
single
|
In flap method of amputation, which structure is kept shoer than the level of amputation?
|
Bone is kept shoer than soft tissue in flap method of amputation to facilitate closure of amputation stump. Also know: In guillotine amputation, limb is transected at one level through skin, muscle and bone. Ref: Campbell's operative Ohopaedics 10/e, page 544.
| 1
|
Bone
|
Muscles
|
Nerves
|
Vessels
|
Surgery
| null |
4e5a58f6-5a3c-49da-a0eb-d87b902422ce
|
single
|
Treatment of parathyroid hyperplasia is:
|
TREATMENT OF PRIMARY HYPERPARATHYROIDISM Initial correction of hypercalcemia (Rapid IV normal saline followed by Forced diuresis with furosemide) Neck exploration is done and treatment is done accordingly A single parathyroid adenoma (85%) Resection Two adenomas (5%) Resection Hyperplasia of all four glands (10-15%) Resection of 3 1/2 glands or Resection of all four glands With Parathyroid auto transplantation - into Brachioradialis of non-dominant arm PARATHYROID AUTO TRANSPLANTATION Whenever multiple parathyroids are resected, it is preferable to cryopreserve tissue, so that it may be autotransplanted Approx. 12-14 pieces of 1 mm are transplanted into the nondominant forearm in belly of brachioradialis muscle
| 3
|
Phosphate binders
|
Calcitonin
|
Removal of 3 1/2 glands
|
Enlarged glands to be removed
|
Surgery
|
Parathyroid and adrenal glands
|
8c589a5a-76e7-44c7-bae3-68a033c98090
|
single
|
Broca's area is situated in
|
(A) Inferior frontal gyrus[?]BROCA'S AREA (Motor Speech Area) is a section of the human brain that is involved in language processing, speech or sign production & comprehensionBroca's area is located in the opercular and triangular sections of the Inferior Frontal Gyrus of the Frontal lobe of the Cortex.Broca's & Wernicke's areas are found unilaterally in the brain (left hemisphere) dominant hemisphere.Broca's area comprises Brodmann area 44 and (according to some authorities) Brodmann area 45.Broca's Area is connected to Wernicke's area by a neural pathway called the arcuate fasciculus.Inability to speak after injury to the posterior-inferior frontal gyrus of the brain.Pierre Paul Brocahe identified this region, known as Broca's area.Difficulty in language production as Broca's aphasia, also called expressive aphasia.Broca's area is now typically defined in terms of the pars opercularis & pars triangularis of the inferior frontal gyrus.Present in left hemisphere in 90% of right handed & 70% of left handed people.Present in right hemisphere only in any of left handed peopleCEREBRAL CORTEX & CORTICAL AREAS AT A GLANCEAREALOCATIONFUNCTION* Motor area (Area 4)Precentral gyrus & anterior part of para-central lobuleVoluntary movements* Premotor area (Area 6)Posterior parts of frontal gyriVoluntary movements* Frontal eye field (8) Includes Areas 6 & 9Anterior to premotor area in posterior part of middle frontal gyrusConjugate deviation of eyes to opposite side.* Broca's speech area (Areas 44,45)Posterior part of inferior frontal gyms of dominant hemisphereControls motor element of speech.* Prefrontal cortexAnterior part of frontal gyri, orbital gyri, most of medial frontal gyms, & anterior part of cingulate gyms.Intellectual activity* Sensory Cortex (Areas 3,1,2)Post central gyms & adjoining parts of post central gyms & posterior part of para-central lobuleAppreciation of somatic sensations* Areas 39,40Inferior parietal lobule, supra marginal & angular gyri.Recognition of somatic sensory stimuli & their integration steriognosis* Primary visual area (17) Visual cortex or striate cortex (Visual-Sensory Cortex)Surrounds post calcarine sulcus.Primary visual function* Visual association cortex (18,19) (peristriate & parastriate areas) (Visual-Psychic)Occipital lobe adjacent to striate areaRecognition & integration of visual stimuli* Primary acoustic area (41) or 1st acoustic area (Al)Anterior transverse temporal gyms extending to superior temporal gymsPrimary auditory function* Auditory association area (Area 42)Posterior transverse temporal gymsIntegration of auditory stimuli with other sensory modalities.* Area 24Anterior part of cingulate gymsPulse, Respiration & B.P. control* Limbic systemHippocampus, alveus, fimbria, fornix & its termination into mamillary bodies are grouped under this systemMaintenance of normal homeostasis of body along with hypothalamus.* Second speech area of WernickeOccupies parietal area extending into temporal lobe round the posterior extremity of lateral sulcus.Second motor speech area.
| 1
|
Inferior frontal gyrus
|
Superior temporal gyrus
|
Inferior temporal gyrus
|
Parietal gyrus
|
Anatomy
|
Neuroanatomy
|
c30099a5-8741-49f3-b9e6-4e7ef5bee3be
|
single
|
Nerve running along with profunda brachii aery, in spiral groove ?
|
Profunda brachii is a branch of brachial aery. It accompanies radial nerve in spiral groove.
| 3
|
Ulnar
|
Median
|
Radial
| null |
Anatomy
| null |
3abd7a48-7081-4e74-992f-6ac79a81ff5d
|
multi
|
A 39-year-old man repos seeing red-colored urine in the morning. The CBC reveals anemia, low serum iron, and an elevated reticulocyte count. Laboratory studies show increased lysis of erythrocytes when incubated with either sucrose or acidified serum. Which of the following is the appropriate diagnosis
|
- Given clinical features suggests the diagnosis of PNH - Despite its name, the disorder is nocturnal in only a minority of cases. - PNH is a clonal stem cell disorder characterized by episodic intravascular hemolytic anemia; secondary to increased sensitivity of erythrocytes to complement-mediated lysis. - It is d/t somatic mutation of phosphatidylinositol glycan-class A (PIG-A) gene. - Most useful diagnostic test is flow cytofluorometry. - other tests used are: Sucrose hemolysis test Acidified serum (Ham test) - Choices B and C are hemolytic conditions, do not show increased lysis in described laboratory studies.
| 4
|
Anemia of chronic renal failure
|
Hereditary spherocytosis
|
Microangiopathic hemolytic anemia
|
Paroxysmal nocturnal hemoglobinuria
|
Pathology
|
Hemolytic Anemias: Basic concepts and classification
|
8f6ecfae-518f-4da8-bd2d-1c9fbf15b0a7
|
single
|
A 70-year-old male underwent a choledochoduodenostomy for multiple common duct stones. The patient now presents with RUQ abdominal pain. What should be the initial test (least invasive with the best yield) to determine patency of the choledochoduodenostomy?
|
A HIDA scan will show excretion of the radiolabeled isotope into the biliary tree, but there will be no flow into the duodenum, indicating that the biliary-enteric anastomosis is occluded. If an upper GI study with barium is performed, visualization of the common bile duct would indicate patency of the choledochoduodenal anastomosis.
| 3
|
ERCP
|
Percutaneous transhepatic cholangiogram (PTC)
|
HIDA scan
|
CT scan of the abdomen
|
Surgery
|
Pancreas
|
607ccc98-4671-410c-8aae-7d5e22c155af
|
single
|
40/F presented to AIIMS OPD with the following findings-Hb-9.8gm%, TLC= 15,700/cumm, Platelet counts 3 lac/cumm. Peripheral smear showed increased neutrophils with 14 % blasts, 15% myelocytes and metamyelocytes with some dysplasia. Cytogenetic study revealed t(8;21). What is your diagnosis?
|
Ans. (a) AML(Ref: Robbins 9th/pg 612; 8th/pg 622)This 40 yr old female is presenting with leukocytosis and increased blast counts in the peripheral smear. The cytogenetic study done here shows t(8;21). This finding is suggestive of Acute myeloid leukemia even if there are <20% blast counts.It cytogenetic abnormalities like t(15;17),t(8;21), inv(16) are encountered in a patient with symptomatic myeloid disease, AML should be diagnosed despite the lower blast percent.
| 1
|
AML
|
CML
|
MDS
|
ALL
|
Pathology
|
Misc. (W.B.C)
|
8e3738f8-e29d-4068-af13-d3054125c097
|
multi
|
A patient with Hepatitis C, exhibits hypo-complimentemia with 2 gm/day protein uria and hematuria. The most probable diagnosis is
|
Ans. a. MPGN Type I MPGN is c.ommonly associated with persistent hepatitis C infections, autoimmune diseases like lupus or cryoglobulinemia, or neoplastic diseases."- Harrison 18/e p2344 So, in the above mentioned patient with Hepatitis C, exhibits hypo-complimentemia with 2 gm/day proteinuria and hematuria. The most probable diagnosis is MPGN Membranoproliferative Glomerulonephritis MPGN is sometimes called mesangiocapillary glomerulonephritis or lobar glomerulonephritis. It is an immune-mediated glomerulonephritis characterized by thickening of the GBM with mesangioproliferative changes; 70% of patients have hypocomplementemiaQ. MPGN is subdivided pathologically into type I, type II, and type III disease. Type I MPGN is commonly associated with persistent hepatitis C. infectionsQ, autoimmune diseases like lupus or cryoglobulinemiaQ, or neoplastic diseases Types II and HI MPGN are usually idiopathic`, except in patients with complement factor H deficiency, in presence of C3 nephritic factor and/or in paial lipodystrophy producing type II disease, or complement receptor deficiency in type III disease. Membranoproliferative Glomerulonephritis Type I MPGN (Most Common) Idiopathic SABEQ SLEQ Hepatitis CQ +- cryoglobulinemia Mixed cryoglobulinemia Hepatitis bQ Cancer: Lung, breast and ovary (germinal) Type li MPGN(Dense Deposit Disease) Idiopathic C3, nephritic factorassociatedQ Type Ill MPGN Idiopathic Complement receptor deficiencyQ
| 1
|
MPGN
|
Cryoglobulinemia
|
Membranous glomerulopathy
|
Post-infectious glomerulonephritis
|
Medicine
| null |
84f25871-7ef4-44d1-bc4f-5d4a2b03ec32
|
single
|
A body is brought for autopsy. On postmoem, there is dark brown postmoem staining and garlic odor in stomach. The poisoning is most likely due to
|
PHOSPHORUS(P4) There are two varieties: (1) White or crystalline. (2) Red or amorphous Postmoem Appearances:- In acute poisoning, the body usually shows signs of jaundice. The gastric and intestinal contents may smell of garlic and be luminous. The mucous membranes of the stomach and intestine are yellowish or greyish-white in colour, and are softened, thickened, inflamed and corroded or destroyed in patches. Multiple smaller or larger haemorrhages are seen in the skin, subcutaneous tissues, muscles, and serosal and mucosal membranes of gastrointestinal and respiratory tract, under endocardium, pericardium, epicardium, peritoneum, in lungs, brain, leptomeninges and uterus. The liver becomes swollen, yellow, soft, fatty and is easily ruptured. Small haemorrhages may be seen on the surface and in the substance. The kidenys are large, greasy, yellow and show haemorrhages on the surface. The hea is flabby, pale and shows fatty degeneration. Fat emboli may be found in the pulmonary aerioles and capillaries. The blood may appear tarry and its coagulability is diminished. Ref:- k s narayan reddy; pg num:-551
| 4
|
Aniline dye
|
Carbon dioxide
|
Hydrocyanic acid
|
Phosphorus
|
Forensic Medicine
|
Poisoning
|
1bb283bb-b236-4cfe-bd84-e2676bec6369
|
single
|
The sensory supply of the palate is through all of the following except
|
Palate is supplied by trigeminal (maxillary, mandibular), facial & glossopharyngeal nerves
| 2
|
Facial nerve
|
Hypoglossal nerve
|
Glossopharyngeal nerve
|
Maxillary division of trigeminal nerve
|
Anatomy
| null |
c3acad89-02de-457c-8dc6-a420193ac355
|
multi
|
Following clostridia are saccharolytic except
|
When grown in Robeson cooked meat broth, saccharolytic species turn meat pink and proteolytic species produce black and produce foul and pervasive odours. Clostridium welchii, Clostridium septicum and Clostridium oedematiens are predominantly saccharolytic. Clostridium sporogenes is predominantly proteolytic. Reference: Textbook of Microbiology; Anathanarayan and paniker's; 10th edition; Page no: 258
| 2
|
Welchii
|
Sporogenes
|
Septicum
|
Oedematiens
|
Microbiology
|
Bacteriology
|
229e2ef1-402a-47e7-bbd1-c565e46c403c
|
multi
|
In the metabolism of alcohol, high doses of aspirin & phenytoin, mechanism is -
|
Ans. is 'c' i.e., Zero order kinetics o The drugs whose kinetics changes from first order to zero order at therapeutic concentration are said to follow pseudo - zero order kinetics or mixed order kinetics or saturation kinetics.o Drugs showing zero/pseudo-zero order kinetics :# Phenytoin# Theophylline# Alcohol# Tolbutamide# Warfarin# Salicylates (Aspirin)# Propanolol (ref- Pharmocolgy recap) First Order KineticsZero Order Kinetics (Non linear Kinetics)1. Constant fraction of drug is eliminated per unit time2. Rate of elimination is proportional to plasma concentration3. Clearance remains constant4. Half life remains constant5. Most of the drugs follow first order kinetics1. Constant amount of the drug is eliminated per unit time.2. Rate of elimination is independent of plasma concentration3. Clearance is more at low concentrations and less at high concentrations4. Half life is less at low concentrations and more at high concentrations5. Very few drugs follow pure zero order kinetics e.g. alcohol6. Any drug at high concentration (when metabolic or elimination pathway is saturated) may show zero order kinetics
| 3
|
First pass kinetics
|
First order kinetics
|
Zero order kinetics
|
Second order kinetics
|
Pharmacology
|
Pharmacokinetics
|
fa962efe-7a98-4af3-aab9-77a271699bda
|
single
|
Which of the following is a negative symptom of Schizophrenia?
|
Anhedonia- lack of pleasure in a previously pleasurable activity Negative symptoms in Schizophrenia are: Apathy- Lack of concern Avolition- Loss of drive for goal directed activities Asociality- Lack of social interaction Affective flattening or blunting Alogia- Lack of speech output Anhedonia- Lack of pleasure in previously pleasurable activities. The more the negative symptoms in an individual with Schizophrenia, the worse is the prognosis.
| 3
|
Ambivalence
|
Automatic obedience
|
Anhedonia
|
Delusion
|
Psychiatry
|
Schizophrenia Spectrum and Other Psychotic Disorders
|
f6369973-a4e8-4a9f-8e60-48c782f6f93a
|
single
|
Causes of painful arc syndrome is/ are -
|
Painful arc syndrome is characterised by pain in the shoulder and upper arm during the mid range of gleno-humeral abduction. Causes are *supraspinatus tendinitis *subacromial bursitis *fracture of greater tuberosity *calcification of supraspinatus tendon *minor tears of the supraspinatus tendon In all these conditions the space between the upper end of the humerus and the acromion gets compromised, so that during mid abduction the tendon of rotator cuff gets nipped between the greater tuberosity and acromion. Reference-Essential ohopaedics- Maheshwari -5th edn-pg no 304
| 4
|
Supraspinatus tendinitis
|
Subacromial bursitis
|
Fracture of greater tuberosity
|
All the above
|
Orthopaedics
|
Bony dysplasia and soft tissue affection
|
b389d2f6-4f79-404a-af1f-e4896908e022
|
multi
|
A child had pustular lesion on leg. On gram staining gram positive cocci are seen. To establish the diagnosis of Group A beta streptococcal pyoderma, the test used is:
|
Group A beta streptococcus produces pyogenic infections with a tendency to spread locally, along lymphatics and through the bloodstream. The growth of Str. pyogenes on agar plates in the laboratory is inhibited by the antibiotic bacitracin, an impoant diagnostic criterion. Sensitivity to bacitracin is a convenient method for differentiating Group A streptococcus from other hemolytic streptococci. Laboratory tests for group A beta streptococcus: Bacitracin sensitive PYR (pyrrolidonyl naphthylamide) test positive Ribose not fermented Ref: Ananthanarayan and Paniker's Textbook of Microbiology By Ananthanarayan And Paniker, 7th edition, Page 205.
| 4
|
Bile solubility test
|
Catalase test
|
Optochin sensitivity
|
Bacitracin sensitivity
|
Microbiology
| null |
4b4fb4e9-4255-4af3-b416-87652f1ee03b
|
single
|
Not useful for acute Hypercalcemia?
|
Ans. is 'c' i.e., Furosemide Treatment for hypercalcemia depends upono The underlying disease.o The severity of hypercalcemia.o The serum inorganic phosphate level ando The renal hepatic and bone marrow function. o Mild hvpercalcemias< 3 mmol/l (12 mg/dl)-Managed by hydration aloneo More severe hvoercalcemia3.2 to 3.7 mmol/l (13 to 15 mg/dl)-Requires rapid correction measures other than hydration.It requires combination of approaches.o Life threatening hypercalcemia>3.7 mmol/L (15 mg/dL)-Requires emergency measures TreatementOnset of ActionDuration of ActionAdvantagesDisadvantagesMost Useful Therapies Hydration with salineHoursDuring infusionRehydration invariably neededVolume overloadForced diuresis; saline plus loop diureticHoursDuring treatmentRapid actionVolume overload, cardiac decompensation, intesive monitoring, eletrolyte disturbance, inconvenienceBisphosphonates Pamidronate1-2 days10-14 days to weeksHigh potency, intermediate onset of actionFever in 20%, hypophosphatemia, hypocalcemia rarely jaw necrosisZolendronate1-2 days> 3 weeksSame as for pamidronate (may last longer)Same as pamidronate aboveCalcitoninHours1-2 daysRapid onset of action; useful as adjunct in severe hypercalcemiaRapid tachyphylaxisSpecial Use therapies PhosphateOral24 hDuring useChronic management (with hypophosphatemia); low toxicity if P< 4 mg/dLLimited use except as adjuvant or chronic therapyGlucocorticoidsDaysDays, weeksOral therapy, antitumor agentActive only in certain malignancies vitamin D excess and sarcoidosis; glucocorticoid side effectsDialysisHoursDuring use and 24-48 afterwardUseful in renal failure; onset of effect in hours; can immediately reverse life-theratening hypercalcemiaComplex procedure, reserved for extreme or special circumstances
| 3
|
Normal saline
|
Calcitonin
|
Furosemide
|
Bisphosphonates
|
Medicine
|
Fluid & Electrolyte
|
820221d3-220c-41ca-9015-d75a06df5046
|
single
|
A 20 year old female has an erythematous rash over her face on both cheeks and across the bridge of her nose.This rash is made worse by sunlight exposure when she is outdoors. Along with the rash, she has had muscle and joint pain for several month. However, radiographs of the joints does not show any abnormalities, and she has normal joint mobility without deformity. Which of the following laboratory test findings is most characteristic of the disease-
| null | 4
|
Elevated anti-streptolysin 0 (ASO) titer
|
HLA-B27 genotype
|
Markedly decreased serum level ofimmuno-globulin G (IgG)
|
Antibodies to double-standed DNA
|
Pathology
| null |
6bf854e8-e3ba-4efe-9324-4b0c643ac026
|
multi
|
All are features of adipocere, except: MAHE 11; PGI 13
|
Ans. Takes place in bodies buried in dry sandy soil
| 2
|
It consists of fatty acids
|
Takes place in bodies buried in dry sandy soil
|
Takes about 3 weeks to form
|
Bacterial enzymes are necessary for its formation
|
Forensic Medicine
| null |
244ea874-cdbc-4787-acea-8633295c5db9
|
multi
|
Neutrophilic leucocytosis is seen in all except
|
Acute myocardial infarction ST-elevation (STEMI) is frequently associated with leukocytosis and relative increased in neutrophil count. It is believed that the peripheral leukocyte count have impoant prognostic implication in AMI. In patients with leukocytosis, the possibility of infection always exists, especially with neutrophilia and no prior documentation of leukocytosis. However, the risk of aggressive and overwhelming infection and sepsis is increased due to the paucity of neutrophils Background. Spinal infection may be defined as an infectious disease that affects the veebral body, the interveebral disk, or adjacent paraspinal tissue. It accounts for 2-7% of all musculoskeletal infections. Pyogenic veebral osteomyelitis is the most commonly encountered form of veebral infection Ref Davidson 23rd edition pg 225 , harriosns 203 p328
| 4
|
Sepsis
|
Myocardial infarction
|
Pyogenic osteomyelitis
|
Hay fever
|
Medicine
|
Miscellaneous
|
4d8d2465-7961-44a5-98f5-f57ce0daff42
|
multi
|
All are true of Henoch Scholein' s purpura, except
|
Answer is A (Thrombocytopenia) : Purpura in 'Henoch Shonlein purpura' is due to vasculitis and not thrombocytopenia.
| 1
|
Thrombocytopenia
|
Abdominal pain
|
Ahritis
|
GI bleed
|
Medicine
| null |
eb2416c8-6944-4b77-8b29-cf6ad1a87fb1
|
multi
|
Mechanism of action of oral contraceptives containing ethinyl oestradiol and a progesterone is :
|
Inhibiting ovulation
| 1
|
Inhibiting ovulation
|
Inhibiting the implantation
|
Thickening of cervical mucus
|
None of the above
|
Gynaecology & Obstetrics
| null |
24b62c8c-259d-4307-86a1-d4d986b1fdd7
|
multi
|
Hyoid bone fracture does not occur in: NEET 14
|
Ans. Choking
| 4
|
Hanging
|
Strangulation
|
Throttling
|
Choking
|
Forensic Medicine
| null |
18179cc4-8379-4a44-b9c5-13a74191a2bb
|
single
|
Larger DNA segments can be cloned in
|
Hybrid DNA molecules can be constructed in cloning vectors typically using bacterial plasmids, phages, or cosmids. A clone is a large population of identical molecules, bacteria, or cells that arise from a common ancestor. Molecular cloning allows for the production of a large number of identical DNA molecules, which can then be characterized or used for other purposes. Cloning capacities of vectors Plasmid 0.01-10 kb Lambda phage 10-20 kb Cosmids 35-50 kb Bacterial aificial chromosome 50-250 kb Yeast aificial chromosome 500-3000 kb
| 4
|
Plasmids
|
Bacteriophage
|
Cosmids
|
Bacterial Aificial Chromosomes
|
Biochemistry
|
Techniques in molecular biology
|
7c394da1-379a-4ab8-85b2-1983d534aac0
|
single
|
According to Pugh's classification moderate to severe hepatic insufficiency is managed by:
|
Ans. (c) Orthotopic liver transplantation* Child A and B can be managed with Conservative methods/Shunt surgeries etc.* Child C is an indication for Liver Transplant* Other Major surgeries can be done only for Child A* Minor surgeries only can be done in Child B* No other surgery other than Transplant is advised in Child C
| 3
|
Sclerotherapy
|
Conservative
|
Orthotopic liver transplantation
|
Shunt surgery
|
Surgery
|
Liver
|
8034c9b2-48dc-4687-a72e-96f00b9628be
|
single
|
Microcytic hypochromic anaemia is seen in all except-
| null | 3
|
Beta thalassemia
|
Iron deficiency
|
Malaria
|
Lead poisoning
|
Medicine
| null |
d12b8435-8108-4445-ad6e-02fade6462b5
|
multi
|
Surface Immunoglobulin is found in which cell ?
|
Ans is b' i.e. B-cell B cells recognize antigen the B-cell antigen receptor complex.Ig M and Ig D, present on the surface of all naive B cells, constitute the antigen binding component of B-cell receptor complex.After antigenic stimulation, B cells form plasma cells that secret immunoglobulin.
| 2
|
T-cell
|
B-cell
|
NK cell
|
Plasma cells
|
Pathology
| null |
72a67203-e5d9-4ea8-9946-f25d93630a93
|
single
|
Night blood survey is done in ?
|
Ans. is 'a' i.e., Filaria The microfilariae of W. bancrofti and B. malayi occuring in India display a nocturnal periodicity, i.e., they appear in large number at night and retreat from the blood stream during the day. This is a biological adaptation to the nocturnal biting habits of vector mosquitoes. The maximum density of microfilariae in blood is repoed between 10 pm and 2am. When the sleeping habits of the host are altered, a reversal in periodicity has been observed
| 1
|
Filaria
|
Typhoid
|
Malaria
|
Kala-azar
|
Social & Preventive Medicine
| null |
2fc8ef15-0f97-45d0-bb4c-19ed1c86a062
|
single
|
Essential pentosuria is due to deficiency of
|
Repeated question
| 3
|
Gulonolactone oxidase
|
Phosphoglucomutase
|
Xylulose reductase
|
Fructokinase
|
Biochemistry
|
Metabolism of carbohydrate
|
cf5e8420-b313-443d-823e-072827563a7e
|
single
|
Simple squamous epithelium is seen in
|
Squamous epithelium lines theinside of the hea ,where it is called endothelium INDERBIR SINGH&;S TEXT BOOK OF HUMAN HISTOLOGY-REFERENCE page no:41
| 1
|
Blood vessels
|
Thyroid follicle
|
Esophagus
|
Hard palate
|
Anatomy
|
General anatomy
|
b39377c2-e8a7-47ed-b462-eba630e740fb
|
single
|
Tomcat urine odor is seen in:
|
MULTIPLE CARBOXLASE DEFICIENCY - BIOTIN is coenzyme in carboxylase reaction. Defects in the ability to add or remove biotin from carboxylases result in multiple carboxylase deficiency. It is autosomal recessive Developmental delay Treatment is biotin supplement Tomcat Urine odour
| 1
|
Multiple carboxylase deficiency
|
Phenylketonuria
|
Hawkinuria
|
Maple syrup disease
|
Biochemistry
|
Classification and metabolism of amino acids
|
7a0367db-ba88-49b9-9dc2-a52da553dbec
|
single
|
Macula is
|
Ans. Constant blinking
| 4
|
Optic nerve
|
Optic tract
|
Periodic bluring of vision
|
Constant blinking
|
Ophthalmology
| null |
fd47dbd6-756f-4a3a-85d4-4baf035008de
|
single
|
During resuscitation, fractured ribs most commonly involve:
|
Ans. c. 4th -- 6th ribs Reasonable conclusions to be drawn from the literature in relation to rib fractures in adults Rib fractures following CPR in adults are quite common - 30 to 60% of prospective post-moem studies. Post-CPR rib fractures are often bilateral. The site of rib fracture is dependent on: the position of the hands; force used; and method of chest compression (manual or device-assisted). The vast majority (90%+) offractures occur in ribs 2 to 7; fractures in the bony pas of rib numbers 1 and 8 to 10 are possible but probably very rare; it is difficult to see how fractures can occur in rib numbers 11 and 12 following standard manual CPR. The vast majority of fractures (90%+) occur in the anterior third of the bony pa of the rib, some occur in the middle third but - following standard manual CPR - none in the posterior third of the bony pa of the rib. Posterior rib fractures occur following automated band-type CPR. Lateral fractures i.e. those occurring between the anterior and posterior axillary lines, do occur after standard CPR. If a fracture is noted in rib numbers 10 to 12 or in the posterior third of the bony pa of a rib, then non-resuscitation trauma should be suspected. Chest x-ray is unreliable as a diagnostic tool for detecting rib fractures. CT is better than x-ray and may complement the post-moem detection of rib fractures. Fractures are more common On the left side of the chest With increasing age of the patient In females With increasing length of time of resuscitation attempts Following the involvement of untrained persons With the use of ACD-CPR
| 3
|
2nd -4th ribs
|
3rd -5th ribs
|
4th -6th ribs
|
5th -7th ribs
|
Surgery
| null |
bf7c0271-03c3-4504-bc98-8a995fe7b583
|
single
|
In a pregnant female which drug is strictly contraindicated?
|
Ref: Goodman & Gillman 13th ed. P 1045; Harrison 20th edition, Page 1112* Streptomycin is highly ototoxic (vestibulotoxic >> Cochleotoxic) and nephrotoxic drug.* It is strictly contraindicated throughout the pregnancy.Drugs during pregnancy Drugs safe in pregnancyDrugs contraindicated in pregnancy (Safety uncertain)* Anti-tubercularIsoniazid, Rifampicin, Pyrazinamide, EthambutolStreptomycin* AntiamoebicDiloxanide furoate, paromomycinMetronidazole, Tinidazole, Quiniodochlor* AntimalarialChloroquine, Mefloquine, Proguanil, Quinine (only in 1st trimester)Primaquine* AntifungalTopical:Clotrimazole, Nystatin, TolnaftaneAmphotericin B, Fluconazole, Itraconazole, Ketoconazole, Griseofulvin* Anti allergiesChlorpheniramine,PromethazineCetirizine, Loratadine, Fexofenadine* Anti bacterialsPenicillin G,Ampicillin,Amoxicillin- clavulanate,cloxacillin,Piperacillin,Cephalosporins,ErythromycinCotrimoxazole,Fluoroquinolones,Tetracycline,Doxycycline,Chloramphenicol,Kanamycin,Tobramycin,Clarithromycin,Vancomycin* Antiviral-Ganciclovir, Foscarnet, Amantadine, Vidarabine, a-interferon* Anti-retroviralZidovudine, Lamivudine, tenofovir, Nelfinavir, Nevirapine, Saquinavir, EfavirenzDidanosine, Abacavir, Indinavir, Ritonavir* Anti-diabeticInsulin (preferably human insulin)Sulfonylureas, metformin, Acarbose, pioglitazone, Repaglinide* Thyroid drugsPropylthiouracilCarbimazole, Radioactive iodine (X), Iodide
| 1
|
Streptomycin
|
Isoniazid
|
Cephalosporins
|
Penicillin
|
Pharmacology
|
Anti Microbial
|
f7eac2ec-ae38-4bd5-b41c-2c5f1f989d18
|
single
|
Which of the following ultra-violet radiation cause most skin disorder-
|
Cutaneous responses to uv radiation UVA -315-400nm immediate erythema Immediate pigment darkening- merowsky phenomenon drug induced photosensitivity photoageing UVB- 280-315nm 1000x more erythmogenic, associated with sunburn delayed melanogenogenesis major role in carcinogenesis role in photoageing role in vitamin d synthesis UVB has more damage to skin fitzpatrick textbook of dermatology page 267
| 2
|
UV-A
|
UV-B
|
UV-C
| null |
Dental
|
Photosensitive disorders
|
fbe13630-060b-40c0-b466-33fb189ca959
|
multi
|
Which of the following is not a feature of primary tuberculosis: September 2010
|
Ans. A: Apical lung cavityThe primary complex generally exists singly and only occasionally in multiple units.In overwhelming majority of cases primary complex occurs in the lungs and only in about 5% cases they are distributed among the intestines, Oropharynx, the skin and other rarer sites. The primary focus in the lungs is called as Ghon focus. It generally occurs in the subpleural region of midline and lower lung zones. Mostly hilar and inter-pleural lymph nodes are involved to form the primary complex.Secondary TB is usually localized to apical and posterior segment of upper lobes.
| 1
|
Apical lung cavity
|
Ghon's focus
|
Paratracheal lymphadenopathy
|
Heal spontaneously by fibrosis
|
Pathology
| null |
9c51fc8d-b66b-45b1-b11d-90564c5e1283
|
single
|
Vossius ring occurs in
|
B i.e. Concussion injury
| 2
|
Lens dislocation
|
Concussion injury
|
Penetrating injury
|
Extra capsular extraction
|
Ophthalmology
| null |
e85de612-0a26-401f-ab45-c8b0cfa5b57b
|
single
|
Repeated involuntary regurgitation of food is associated with which of the following disorders?
|
Rumination disorder: Effoless and painless regurgitation of paially digested food into the mouth soon after a meal, which iseither swallowed or spit out According to DSM-5, the disordermust be present for at least 1 month after a period of normal functioning, and not better accounted for by gastrointestinal illness, or psychiatric or medical conditions. Can be observed in normal infants It's a functional gastrointestinal disorder Occurs between 3 months and 12 months of age.
| 2
|
Binge eating disorder
|
Rumination disorder
|
Bulimia nervosa
|
Anorexia nervosa
|
Psychiatry
|
Eating Disorders
|
6283a1c7-e154-4a74-8063-cbb8d71b4d09
|
single
|
A young female patient reports to the dental office with complaint of small gaps between her teeth
If a proper placement technique is not followed, it would result in
| null | 3
|
Tooth sensitivity
|
Wear of opposing teeth
|
Debonded restoration
|
Healthy gingiva
|
Dental
| null |
a76da0bd-78c9-471a-af60-8c1331e21d55
|
multi
|
Paneth cells secrete which of the following ?
| null | 1
|
Antibacterial substance
|
Lipase
|
Maltase
|
Secretin
|
Physiology
| null |
8acfc413-b53a-431f-bdfb-bbf5980b54a0
|
single
|
Sphenoidal sinus opens into:
|
(d) Spheno-ethmoidal recess(Ref. Cummings, 6th ed., 659)The Sphenoid sinus opens into the spheno-ethmoidal recess just above the superior turbinate.
| 4
|
Superior meatus
|
Inferior meatus
|
Middle meatus
|
Spheno-ethmoidal recess
|
ENT
|
Congenital Lesions and Stridor
|
f45d4e97-b043-4ea1-ab1a-d4eaa19a081f
|
single
|
When evaluating an ABG from a client with a subdural hematoma, the nurse notes the PaCO2 is 30 mm Hg. Which of the following responses best describes this result?
|
A normal PaCO2 value is 35 to 45 mm Hg. CO2 has vasodilating properties; therefore, lowering PaCO2 through hyperventilation will lower ICP caused by dilated cerebral vessels.
Option B: Oxygenation is evaluated through PaO2 and oxygen saturation.
Option D: Alveolar hypoventilation would be reflected in an increased PaCO2.
| 1
|
Appropriate; lowering carbon dioxide (CO2) reduces intracranial pressure (ICP).
|
Emergent; the client is poorly oxygenated.
|
Normal
|
Significant; the client has alveolar hypoventilation.
|
Medicine
| null |
ff38bdb0-fdf4-41cd-838b-fb9bc8261d2f
|
single
|
Acute uraemic syndrome causes disturbance in
|
(B) Consciousness # Clinical Abnormalities in Uremiaa> Neuromuscular disturbances Fatigue Sleep disorders Headache Impaired mentation Lethargy Asterixis Muscular irritability Peripheral neuropathy Restless legs syndrome Paralysis Myoclonus Seizures Coma Muscle cramps Dialysis disequilibrium syndrome Myopathy
| 2
|
Affect
|
Consciousness
|
Thought
|
Memory
|
Medicine
|
Miscellaneous
|
f4ce859c-2d05-4d15-a695-6127f9cd5e1d
|
single
|
Potato nodes are feature of?
|
ANSWER: (A) SarcoidosisREF: Chest radiology: the essentials By Jannette Collins, Eric J. Stern, page 165, http://medical- dictionary.thefreedictionary.com/potato+node* Sarcoidosis is a systemic disease characterized by non-caseating granulomas in multiple organs.* In 90% of cases, Symmetrical massive bilateral hilar lymphadenopathy clear or the cardiac border ("potato nodes") or lung involvement is present and can be revealed by chest x-ray or Trans-bronchial biopsy.* The eye and skin are the next most commonly affected organs, so that both Conjunctival and skin biopsies are clinical possibilities.* Sarcoidosis is not caused by any known organism. Therefore, before the diagnosis of Sarcoidosis can be made, cultures must be taken from affected tissues, and there must be no growth of any organism that may produce granulomas. In patients with Sarcoidosis, blood levels of angiotensin-converting enzyme are increased, and this may also be used as a clinical test.* In the past, the Kveim skin test was used to assist in the diagnosis of Sarcoidosis, but since it involves injecting into patients extracts of material from humans, it is no longer used.Note: Don't get confuse with 'cut potato appearance'of lymphoma
| 1
|
Sarcoidosis
|
Tuberculosis
|
Carcinoid
|
Lymphoma
|
Surgery
|
Miscellaneous
|
0ee3f7c7-d1bc-4176-b957-9ff55348790a
|
single
|
In venturi mask maximum O2 concentration attained is
|
Maximum concentration delivered by ventimask (venturimask) is 60%.
| 3
|
90%
|
100%
|
60%
|
80%
|
Anaesthesia
| null |
cf4ca71d-373b-4e97-a5d1-758bf63b2ed1
|
single
|
Dihydroergotamine differs from ergotamine in the following respect :
|
Hydrogenation of ergot alkaloids decrease their vasoconstrictor action and increase the α-blocking activity.
| 4
|
It is a more potent oxytocic
|
It has antiemetic property
|
It has high oral bioavailability
|
It is more potent α-adrenergic blocker and less potent vasoconstrictor
|
Pharmacology
| null |
ef4c4401-c538-4aa7-b5d2-11fd15548b25
|
single
|
A woman consumes several tabs of Amitryptilline (case of amitryptiline poisoning). All of the following can be done exceptaEUR'
|
Atropine as antidote Tricyclic s include Amitriptvline Clornipramine Imipramine Tricyclics act primarily by inhibiting serotonin and norepinephrine reuptake. It result in elevation of extracellular concentration of these drugs. The toxic effects of tricyclics are caused by four main phannacological propeies. a) Inhibition of norepinephrine reuptake at nerve terminals. b) Direct a adrenergic block c) Membrane stabilising or quinidine like effect on myocardium. d) Anticholinergic action The clinical feature of tricyclic overdose can be grouped according to their effects on the peripheral autonomic nervous system. Management of tricyclic overdose Assess and treat ABC as appropriate Examine for clinical features - Check urea and electrolytes -4 Look.for low potassium - Check aerial blood gases Look for acidosis Reducing absorption Consider gastric lavage only if within one hour of a potentially fatal overdose. -Lavage improves clinical condition only when given within one hour of ingestion of Amitriptylline. - "Activated charcoal" may reduce the absorption of TCA's and benefits of both simple and multiple doses have been described. - Emetic contraindicated. Alkalinisation Alkalinization with sodium bicarbonate seems to have beneficial effect. Alkalinization correct hypotension and arrhythmias. The mechanism of this effect is a subject of debate. - It is believed that plasma protein binding of amitriptylline increases with a more alkaline pH. - The protein bound .form is inactive. Non protein bound form is the active .fonn, this reduces the pharmacological active unbound fraction. The reduction in unbound. fraction also reduces the direct effect on myocardium. Give Sodium bicarbonate when: ? pH < 7.1 RS > .16 seconds Arryhthmias Hypotension Hypotension Give intravenous fluids Hypotension results from depression of myocardial contractility and peripheral vasodilatation. In cases refractory to the use of intravenous fluids inotropic agents may be required. Arryhthmias In general antiarryhthmic agents should be avoided and the correction of hypoxia, hypotension, acidosis, hypokalemia should be done to reduce the cardiotoxic effects of tricyclics. Seizures Seizures are usually self limiting but where t/t is necessary benzodiazepenes are the t/t of choice. Cardiac arrest Prolonged resuscitation may be required. Drug elimination Tricyclic specific antibody fragments have been developed and their effectiveness at reversing cardiovascular toxicity in animals has been demonstrated by several studies. However, experimental work has shown that extremely large amounts are required and at present the use of Fab fragments is limited by cost and possibility of renal toxic effects. Hemodialysis and hemoperfusion not effective.
| 4
|
Sodium bicarbonate infusion
|
Gastric lavage
|
Diazepam for seizure control
|
Atropine as antidote
|
Pharmacology
| null |
d31d3883-6931-4385-ae64-c472b2272471
|
multi
|
A 3 hour old preterm baby develop respiratory grunt and X-ray shows reticulonodular pattern. Diagnosis is
|
Hyaline membrane disease Respiratory distress occurs in the first 6 hours of life Tachypnoea,retractions,cyanosis,grunting,decreased air entry are seen X ray:reticulogranular pattern,ground glass opacity,low lung volume,air bronchogram Ref : ESSENTIAL PEDIATRICS,O.P.GHAI, PG NO:143, 7th edition
| 1
|
Hyaline membrane disease
|
Transient tachypnea of newborn
|
Meconium aspiration syndrome
|
All of the above
|
Pediatrics
|
Respiratory system
|
214c9c98-af60-4ae3-8631-5b1ca8c46e1c
|
multi
|
Following group of drugs is not the first line in the management of chronic
| null | 3
|
Opioids
|
Antiepileptics
|
Dopamine antagonist
|
Serotonergic drugs
|
Anaesthesia
| null |
be576689-98e0-4e4f-9fed-08eea325798b
|
single
|
The principal site of acidification of urine is:
|
Acidification occurs in collecting duct and DCT, but collecting duct is more important. Hence, answer is D>A.
| 4
|
Distal convoluted tubule
|
Proximal convoluted tubule
|
Loop of Henle
|
Collecting duct
|
Physiology
| null |
5c52d59f-320b-4261-85d5-5085e92fd2e9
|
single
|
Keratin in the nail is exceptionally stronger than others because of
|
Mammals contin alpha keratin. It is classified into soft and hard keratin depending on the suphur content. The cysteine residues are resposible for disulphide bridge formation which confers characteristic texture for each type of protein. Soft keratin having low sulphur content is present in skin.Hard keratin is present in hair, horn and nails and has high sulphur content.The disulphide bridges resist the forces that try to deform them. REFERENCE : DM VASUDEVAN TEXTBOOK SEVENTH EDITION ; PAGE NO: 39
| 1
|
Disulphide
|
Van der Wall's forces
|
Ionic bonds
|
Calcification
|
Biochemistry
|
Structure and function of protein
|
06f5a0c0-3346-4ea6-82e8-b7ab1b0f487f
|
multi
|
Organisms that have not been cultured successfully so far is?
|
Pathogenic Treponemes do not grow in aificial culture media. They require a living organism like a virus for their growth REF: Textbook of microbiology Ananthanarayan, and Paniker. Page no.: 371
| 2
|
Leptospira
|
Treponema pallidum
|
Bordetella
|
Staphylococcus
|
Microbiology
|
general microbiology
|
053c22e0-f67f-4edb-90ef-fae4a3fe84b9
|
multi
|
All of the following drugs are used as immuno-suppressants except.
|
Ans. (C) Cephalosporin(Ref: Principles of Pharmacology, 1/e p912; KDT 8/e p937)Cephalosporins are b-lactam antibiotics whereas other drugs are immunosuppressants.
| 3
|
Glucocorticoids
|
Cyclosporine
|
Cephalosporin
|
Azathioprine
|
Pharmacology
|
Immunomodulatory: DMARDS, Monoclonal Antibodies
|
1eb00788-d8e6-4189-973f-1d87de29ccd2
|
multi
|
3 years old child can do ?
|
by 3 years the child can know it&;s full name and gender,copies circle,build bridge with blocks. The child can pronounce I,u and me by 2 yrs Ref : OP GHAI - ESSENTIAL PEDIATRICS - 8 TH edition page no..52 and 53</p >
| 1
|
Make bridge of 3 cubes
|
Copy square
|
Identify left and right
|
Use pronounce like I, you & me
|
Pediatrics
|
Growth and development
|
645b902a-d797-4ac6-ae7f-fac614ac91e0
|
single
|
A 17-year-old boy is admitted to the hospital after a road traffic accident. Per abdomen examination is normal. After adequate resuscitation, his pulse rate is 80/min and BP is 110/70 mm Hg. Abdominal CT reveals 1 cm deep laceration in the left lobe of the liver extending from the done more than half way through the parenchyma. Appropriate management at this time would be:
|
Classification of liver injury (Moore) Grade Types Operative or CT Scan findings I Hematoma Laceration Subcapsular, <10% of surface area Capsular tear, < 1 cm in parenchymal death II Hematoma laceration Subcapsular, 10-50% of surface area Intraparenchymal, <10 cm in diameter 1-3 cm in parenchymal depth, <10 cm in length III Hematoma laceration Subcapsular, >50% of surface area or expanding; rupture subcapsular or parenchymal hematoma Intraparenchymal, hematoma > 10 cm or expanding > 3 cm in parenchymal depth IV Laceration Parenchymal disruption involving 25-75% of the hepatic lobe or 1-3 couinauds segments in a single lobe V Laceration vascular Parenchymal disruption involving >75% of the hepatic lobe or > 3 Coulnauds segments in a single lobe Juxta hepatic venous injuries, i.e retro hepatic vena cava / central major hepatic veins VI Vascular Hepatic avulsion
| 1
|
Conservative treatment
|
Abdominal exploration and packing of hepatic wounds
|
Abdominal exploration and ligation of left hepatic aery
|
Left hepatectomy
|
Surgery
|
Trauma
|
2b044139-ce46-42a0-96b6-5b4954697702
|
single
|
As per the Central Bih and Death Registration act, a bih should be registered within:
|
been changed as per "THE REGISTRATION OF BIHS AND DEATHS(AMENDMENT) BILL, 2012 A BILL fuher to amend the Registration of Bihs and Deaths Act, 1969" Ref: Park, 21st Edition, Page 779
| 4
|
7 days
|
10 days
|
14 days
|
21 days
|
Social & Preventive Medicine
| null |
ee165a64-f75d-4e63-abc2-319b963dc8af
|
single
|
Atonic post paum hemorrhage occurs in all except :
|
Erythroblastosis fetalis
| 3
|
Multiple pregnancy
|
Hydramnios
|
Erythroblastosis fetalis
|
Prolonged labour
|
Gynaecology & Obstetrics
| null |
1ce41489-0d7c-4ed3-ae7c-aee9aa54f62a
|
multi
|
Widening of C loop of duodenum is a feature of:
|
A i.e. Pancreatic Head Growth On barium meal, the loop of duodenum is widenedQ also k/a Pad Sign in cases of carcinoma head of pancreas.
| 1
|
Pancreatic head growth
|
Carcinoma stomach
|
Splenic involvement
|
Involvement of upper renal pole
|
Radiology
| null |
5647a8b3-1437-4180-a885-8610c5e16e55
|
single
|
The action of the anconeus muscle is -
|
Action of Anconeus
- Helps triceps in extension of elbow joint.
- Resists abduction of ulna on pronation of forearm.
- Screwing movement
- Elbow joint capsule tensor.
| 1
|
Screwing movements
|
Elbow flexion
|
Forearm supination
|
Adduction
|
Anatomy
| null |
7c011c0d-c4b8-4ee5-be16-9888c55d6c54
|
single
|
Most common method of radiation dose delivery is:
|
Teletherapy REF: therapy, "External radiation therapy (also known as Teletherapy) is the most common kind of radiation therapy"
| 1
|
Teletherapy
|
Electron beam
|
Brachytherapy
|
Radio immunotherapy
|
Radiology
| null |
70f871bc-fe07-448a-89cb-0cb27544626d
|
single
|
True statement about the external nose is
|
External nose has an osteocailaginous framework of which upper one-third is bony and lower two-thirds is cailaginous. Bony pa- Consists of two nasal bones Cailaginous pa: - Consists of two upper lateral cailages, two lower lateral cailages, two or more lesser alar (or sesmoid) cailages anda septal cailage. So, there are 3 paired and 1 unpaired cailages. Ref: PL Dhingra, Diseases of Ear, Nose & Throat, 7th edition, pg no. 149
| 4
|
Upper 2/3 is bony
|
Lower 1/3 is cailaginous
|
Single lateral cailage
|
Two nasal bones
|
ENT
|
Nose and paranasal sinuses
|
ecc69bfb-cf93-46e2-a12a-e50595b386f5
|
multi
|
Which of the following is not a tributary of azygos vein?
|
Tributaries of Azygos vein
Right superior intercostal vein
Right posterior intercostal veins (5 to 11)
Hemiazygos vein
Accessory hemiazygos vein
Right bronchial vein
Esophageal, mediastinal and pericardial veins.
| 3
|
Right posterior intercostal
|
Right superior intercostal
|
Left superior intercostal
|
Accessory hemiazygos
|
Anatomy
| null |
5e8470e0-1461-4767-8baf-affca7c72b35
|
single
|
In a severe untreated case of tuberculous meningitis CSF shows
|
(B) Increased lymphocytes
| 2
|
Increased sugar
|
Increased lymphocytes
|
Increased polymorphs
|
Increased RBCs
|
Medicine
|
Miscellaneous
|
3c97ad9b-c103-4422-9a0f-968654f397c8
|
single
|
Which of the following statements best characterizes natural killer cells?
|
Natural killer (NK) cells account for 5% to 10% of lymphocytes. They paicipate in antibody dependent cellular cytotoxicity reactions (type II hypersensitivity reactions). NK cells are not T cells and are sometimes referred to as null cells. They can lyse virally infected cells and tumor cells without prior sensitization. NK cells are frequently referred to as large granular lymphocytes, and would not be confused with small B cells. When activated by interleukin-l, NK cells become lymphocyte-activated killer cells (LAK cells), which can be used to treat ceain cancers. NK cells are a source of gamma interferon, which induces class II expression and activates macroptIages.
| 4
|
They are a subset of T cells
|
They are involved in type III hypersensitivity reactions
|
They require prior sensitization in order to kill virally infected cells or tumor cells
|
They paicipate in antibody-dependent cellular cytotoxicity reactions
|
Pathology
|
General pathology
|
4a39e3b6-31ad-401d-89ed-39d2bb88d2bf
|
multi
|
Mackler's triad includes all except
|
Mackler's triad is seen in Boerhaave's syndrome. It consists of Vomiting, Chest pain and Subcutaneous emphysema. Reference : page 802 SRB's manual of surgery 5th edition
| 4
|
Vomiting
|
Subcutaneous emphysema
|
Lower thoracic pain
|
Peripheral cyanosis
|
Surgery
|
Urology
|
7cde75bd-6333-424f-b3cc-7806e0c7a892
|
multi
|
Most Common site for carcinoma stomch ?
|
Ans. is 'a' i.e., Antrumo The location of gastric carcinomas within the stomach is as fallows ;Pylorus and antrum 50 - 60%Cardia --> 25%Body and fundus --> Remaindero The lesser curvature is involved in about 40%and the greater curvature in 12%. o Thus, a ored location is the lesser curvature of the antropyloric region.
| 1
|
Antrum
|
Fundus
|
Lesser curvature
|
Greater curvature
|
Pathology
| null |
5d2bb1a6-0320-4ebb-8fde-fd0ad59eccec
|
single
|
36 week a pregnant female, a case of pre-eclampsia, presented with blurred vision and headache. Her blood pressure is 160/110 mmHg. Next step in management is:
|
Termination of pregnancy is the only cure for pre-eclampsia. Headache, visual disturbances, or epigastric pain is indicative that convulsions may be imminent, and oliguria is another ominous sign. Severe preeclampsia demands anticonvulsant and usually antihypeensive therapy followed by delivery. Ref: Cunningham F.G., Leveno K.J., Bloom S.L., Hauth J.C., Rouse D.J., Spong C.Y. (2010). Chapter 34. Pregnancy Hypeension. In F.G. Cunningham, K.J. Leveno, S.L. Bloom, J.C. Hauth, D.J. Rouse, C.Y. Spong (Eds), Williams Obstetrics, 23e.
| 1
|
Admit & give antihypeensives, MgSO4 and terminate
|
Admit & give antihypeensives, MgSO4 and observation
|
Only admit & watch the patient
|
Give antihypeensives and send home
|
Gynaecology & Obstetrics
| null |
0e0e693a-d7a8-4b6e-8a8f-fab0eb0f28f0
|
multi
|
Nux vomica seeds contain 2 alkaloids, strychine and-
|
Nux vomica seeds contain strychine, brucine and loganin.
| 3
|
Hyoscine
|
Hyoscyamine
|
Brucine
|
Atropine
|
Forensic Medicine
| null |
83d82fa5-5a56-46f8-ac07-10c52e34089b
|
single
|
Defect in xeroderma pigmentosum (Repeat)
|
Ans: C (Nucleotide excision repair) Ref: Robbins Pathologic Basis of Disease, 8th edition, Pg: 275 & Frosiius G Commentary: DNA base excision repair defects in human pathologies Free Radic Res. 2004 Oct:38(10): 1037-54.Explanation:Types of defects in DNA-repair systems and conditions associatedDNA Repair MechanismsDiseases associatedMismatch repair* Hereditary Nonpolyposis Colon Cancer Syndrome* Muir-Torre SyndromeNucleotide excision repair* Xeroderma pigmentosum* Cockayne's syndrome* T richothiodystrophyBase excision repair* Gross defects - Not compatible with life* Partial defects -Colorectal cancer & LungRecombinational repairCancers* Ataxia Telangiectasia (ATM gene, genome instability syndrome)* Bloom syndrome (RecQ DNA helicase; BLM gene)* Fancont anemia (BRCA-2)* Werner syndrome (WRNp protein- RecQ DNA helicase)Direct Repair-- DNA damaging agent X-raysoxygen radicals (internal/external) alkylating agents spontaneousUV-light oxygen radicals (internal/external)X-raysoxygen radicals (internal/external) UV-lightanti-tumor agentsreplicationerrorsnon-enzymatic methylation of DNA by cellular S-adenosyl- methionine||Lesions|||Uracilabasic site 8-oxoguanme single-strand break6-4 photoproduct bulky adducts cyclobutane pyrimidine dimerdouble-strandbreakinterstrand-crosslinkA-G mismatchT-C mismatch insertiondeletionO-6-methyl-guanine||Repairprocess|||Base excision repair (BER)Nucleotide excision repair (NER)Recombinational repair (HR/NHEJ)Mismatch repair (MMR)Direct reversal (DR)
| 3
|
Mismatch repair
|
Base excision repair
|
Nucleotide excision repair
|
Double strand break repair
|
Pathology
|
Nature of Gene Abnormalities
|
5768d7d3-a3f0-4e4c-92ea-fe3a3234ed23
|
single
|
Most common intracranial tumor in adults is -
|
Ans. is 'b' i.e., Metastases * Brain metastases are the most common intracranial tumors in adults and account for more than one half of the brain tumors.* The most common mechanism is by hematogenous route.* The most common site is at the junction of grey and white matter.
| 2
|
Astrocytoma
|
Metastases
|
Meningioma
|
Oligodendroglioma
|
Surgery
|
Nervous System
|
8f198dd9-3079-426e-834e-9a28246704ed
|
single
|
Which of the following is false about glutathione
|
Glutatione suppress the formation of methemoglobin.
Rest others are functions of glutathione.
It is a important intracellular reducing substance.
| 4
|
It decrease free radicals, reduces oxidative stress
|
Helps in conjugation reactions
|
Cofactor of enzymes
|
Converts hemoglobin to methemoglobin
|
Biochemistry
| null |
106f919f-580d-4d06-9767-4dec8845a77a
|
multi
|
Which is the most common site for ectopic testis
|
Most common site for undescended testis is inguinal canal
| 2
|
Iliac fossa
|
Inguinal canal
|
Abdomen
|
Lumbar
|
Surgery
| null |
2a8822f2-3ad8-4602-b5e6-38ec91ab2ba3
|
single
|
Amyloid is detected by staining with all except
|
(B) Alcain Blue # Amyloid fibrils are idenfied in biopsy or necropsy tissue sections> The systemic amyloidosis offer a choice of bipsy sites; abdominal fat aspirates or renal or rectal biopsies are often perform ed.> Microscopically, amyloid depsotis stain pink with the hematoxylin-eosin stain and show metachromasia with crystal violet. The widely used and useful Congo red stain imparts a unique green birefringence when stained tissue sections are viewed using the polarizing microsope.> Fluorescent dyes such as thioflavin are sensitive screening stains for amyloid deposits in brain and other tissues; however, specificity should be confirmed.
| 2
|
Methyl violet
|
Alcain Blue
|
Congo Red
|
Thioflavin
|
Pathology
|
Misc.
|
fd233139-2ae4-4222-abdc-b170abcd73be
|
multi
|
The recommended hemoglobin level in male patients with polycythemia rubravera to avoid thrombotic episodes is:
|
Polycythemia rubra vera It is an indolent disorder and thrombosis is the most significant complication. Maintenance of the hemoglobin level at 140 g/L (14 g/dL; hematocrit Phlebotomy : serves to help this aim. Phlebotomy reduce hyperviscosity by bringing the red cell mass into the normal range. Periodic phlebotomies maintain the red cell mass within the normal range. Periodic phlebotomy is usually required at 3-month intervals Ref: Harrison, E-18,P-904.
| 1
|
14 g/dl
|
12 g/dl
|
10g/dl
|
8g/dl
|
Medicine
| null |
e2aa6dd6-d384-4388-bfb9-a24a43b32e1e
|
single
|
In a patient with the burn wound extending into the superficial epidermis without involving the dermis would present with all of the following except
|
.a. Paial thickness burns: It is either first or second degree burn which is red and painful, often with blisters b. Full thickness burns: It is third degree burns which is charred, insensitive, deep involving all layers of the skin.Effects of Burn Injury 1. Shock due to hypovolaemia. 2. Renal failure. 3. Pulmonary oedema, respiratory infection, adult respiratory distress syndrome (ARDS), respiratory failure. 4. Infection by Staphylococcus aureus, beta haemolytic Streptococcus, Pseudomonas, Klebsiella leads to bacteraemia, septicaemia. Fungal and viral infections of dangerous types can also occur. 5. GIT: Hypovolaemia, ischaemia of mucosa, erosive gastritis--Curling's ulcer (seen in burns > 35%). 6.. Fluid and electrolyte imbalance. ref:SRB;s manual of surgery,ed 3,pg no 109
| 2
|
Healing of the wound spontaneously without scar formation
|
Anaesthesia at the site of burns
|
Blister formation
|
Painful
|
Surgery
|
General surgery
|
ae372cb8-5efb-4819-91a2-ad0685cac036
|
multi
|
All of the following statements about Kawasaki disease are true, Except:
|
Answer is C (Thrombocytopenia) : Kawasaki disease is associated with thrombocytosis and not thrombocytopenia.
| 3
|
Immunoglobulin are the treatment of choice
|
Prognosis is good
|
Thrombocytopenia
|
Elevated ESR
|
Medicine
| null |
20556b03-1125-43bc-93f0-2eff4c3e18a9
|
multi
|
Nitric oxide is a potent vasodilator. Where is it produced from?
|
Nitric oxide, known as the 'endothelium-derived relaxing factor', or 'EDRF'. Endothelial cells contain the constitutive form of nitric oxide synthase, which produces moderate amounts of nitric oxide by metabolizing L-arginine. The endothelium of blood vessels uses nitric oxide to signal the surrounding smooth muscle to relax, thus resulting in vasodilation and increasing blood flow. Functions: Endothelium-derived nitric oxide inhibits contraction and proliferation of the underlying vascular smooth muscle, adhesion of blood cells and platelets, and platelet aggregation. Ref: Hypeension Primer: The Essentials of High Blood Pressure By Joseph L Izzo, Jr, Henry R Black, M.D., Theodore L. Goodfriend, 2003, Page 44; Guyton's physiology, 22nd edition, Page 199
| 1
|
Endothelium
|
RBC
|
Platelets
|
Lymphocytes
|
Physiology
| null |
7ce88ecf-4669-4de8-81c6-4ba662e1ffa4
|
single
|
Primary level of prevention means: March 2013 (g)
|
Ans. B i.e. Action taken prior to the onset of disease, which removes the possibility that a disease will ever occur
| 2
|
Effos are directed towards discouraging children from adopting harmful lifestyles
|
Action taken prior to the onset of disease, which removes the possibility that a disease will ever occur
|
Action which halts the progress of a disease at its incipient stage and prevents complications
|
All measures available to reduce or limit impairments and disabilities, minimize suffering caused by existing depaures from good health
|
Social & Preventive Medicine
| null |
11fd55a9-fed9-4c02-8d33-3f414234c00a
|
multi
|
Demyelination is seen in -a) Multiple sclerosisb) AIDSc) Human leukoencephalopathy d) Leukodystrophy
| null | 4
|
ab
|
bc
|
acd
|
abc
|
Medicine
| null |
17db2196-bff7-40a1-8ffa-85798b204b3f
|
single
|
Four A's of schizophrenia was described by: MP 09
|
Ans. Eugene Bleuler
| 2
|
Ku Schneider
|
Eugene Bleuler
|
Karl Jaspers
|
Emil Krapellin
|
Forensic Medicine
| null |
4e020ff6-14fd-4f5d-a94e-a9203b12bcd7
|
single
|
All of the following results in central nervous system manifestation in chronic renal failure, EXCEPT:
|
Hypocalcemia can occur in chronic renal failure patients. But CNS manifestation of hypocalcemia in uremic patients are relatively rare because parathyroid hormone levels are elevated and the calcium concentration in the brain is high. Rarely signs of peripheral nerve hyperexcitability occur in these patients because hypocalcemia develop insidiously and peripheral nerve calcium concentration remain relatively high. Ref: Replacement of Renal Function By Dialysis By Claude Jacobs, 4th Edition, Page 1246
| 3
|
Acidosis
|
Hyperosmolarity
|
Hypocalcemia
|
Hyponatremia
|
Medicine
| null |
94ccf793-8bea-4e15-9033-ec1279f1c5ef
|
multi
|
Which of the following statement about DDT is false-
|
Ans. is `a' i.e., Immediately kills the prey DDT (Dichloro-diphenyl-trichloroetheine) o DDT is an amorphous white powder. o Para-para isomer is the most active fraction --> contains 70-80% ofpara-para isomers. o It is primarily a contact poison. o It acts on CNS of insects and causes paralysis of legs and wings, convulsions and finally death. o It does not cause immediate death and takes several hours to kill the prey. o Its residual action may last as long as 18 months depending upon the treated surface. o It has no repellant action on insects. o Dose of DDT required is 100-200 mg per square foot. o Pyrethrum and DDT have synergistic action.
| 1
|
It is contact poison
|
Residual effect lasts for 18 months
|
Immediately kills the prey
|
Permethrin has synergistic action
|
Social & Preventive Medicine
| null |
4d6ab1ac-4d5e-4b3b-a1ba-5c487ecfc55c
|
multi
|
All are true regarding METHANOL poisoning except
|
Fomepizole is a alcohol dehydrogenase inhibitor not a aldehyde dehydrogenase inhibitor . visual disturbances due to formic acid. Ref: KD Tripathi 8th ed.
| 2
|
Hemodialysis should be done when serum methanol concentration is above 50 mg/dl
|
Fomepizole acts by inhibiting aldehyde dehydrogenase
|
High anion gap metabolic acidosis is seen in severe cases
|
Visual disturbances are commonly seen
|
Pharmacology
|
Central Nervous system
|
56c0aa12-bb49-451e-843b-efce0714cb7d
|
multi
|
An 18-year-old male presented with acute onset descending paralysis of 3 days duration. There is also a history of blurring of vision for the same duration. On examination, the patient has quadriparesis with areflexia. Both the pupils are non-reactive. The most probable diagnosis is -
|
Botulism is caused by neurotoxins of Clostridium botulinum, which are extremely potent & cause disease after ingestion of even picogram amounts. Its classical form is an acute onset of bilateral cranial neuropathies associated with symmetric descending weakness.The toxin causes predominantly bulbar & ocular palsies(difficulty in swallowing ,blurred or double vision ,ptosis),progressive to limb weakness & respiratory paralysis . Reference Harrison20th edition pg 1027
| 2
|
Poliomyelitis
|
Botulism
|
Diptheria
|
Porphyria
|
Medicine
|
Infection
|
30af852c-9cf9-45fd-a814-756e3ccbaf4a
|
multi
|
The following set of findings is seen in Disseminated Intravasular Coagulation (DIC):
|
Common findings in Disseminated Intravascular Coagulation (DIC) include Prolonged Prothrombin Time (PT) and/or Prolonged Paial Thromboplastin Time (PTT), thrombocytopenia, presence of schistocytes and increased levels of fibrin degradation products (FDP). Ref: Harrison's Principles of Internal Medicine, 17th Edition, Page 729; Harrison 16th 7 683 ; Davidson's Principles and Practice of Medicine, 20th Edition, Chapter 24, Page 1060.
| 4
|
Increased fibrinogen, increased antithrombinIII, increased thrombin-antithrombin III complexes
|
Increased FDP, decreased PT, increased antithrombin III
|
Increased FDP, prolonged PT, increased thrombin-antithrombin complexes
|
Increased FDP, prolonged PT, reduced Platelets
|
Medicine
| null |
88b294b5-e0bb-45c0-8582-495a2868c4e6
|
single
|
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