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PIN proteins-PIN proteins-The PM-localized PIN proteins physically interact with a few members of the large PGP family of transporters that also work as auxin efflux carriers (PGP1 and PGP19 in Arabidopsis). These interactions result in a synergistic increase in auxin efflux.
The activity and localization of the PM-loc... | milkshake721/2.1M-wiki-STEM |
Tube (container)-Tube (container)-A tube, squeeze tube, or collapsible tube is a collapsible package which can be used for viscous liquids such as toothpaste, artist's paint, adhesive, caulk, & ointments. Basically, a tube is a cylindrical, hollow piece with a round or oval profile, made of plastic, paperboard, aluminu... | milkshake721/2.1M-wiki-STEM |
Tube (container)-Tube (container)-Typical tube sizes range from 3ml to 300ml. Most tubes are designed to be dispensed with hand pressure, but some are used with a tube key at the base to help roll them up. | milkshake721/2.1M-wiki-STEM |
Tube (container)-History-John Goffe Rand, an American portrait painter, invented the squeezable metal tube in 1841 for paint.Toothpaste in a tube was introduced by Johnson & Johnson in 1889. Not much later, a New London dentist, Washington Sheffield, started selling toothpaste in lead tubes in the 1890s. | milkshake721/2.1M-wiki-STEM |
Tube (container)-Materials-The earliest collapsible tubes were made of tin, zinc, or lead, sometimes coated with wax on the inside.Aluminum tube caps and closures are generally threaded, as is the nozzle. Aluminium tubes generally have the far end folded several times after the contents have been added. The tube is typ... | milkshake721/2.1M-wiki-STEM |
Tube (container)-Materials-Tubes can also be produced in plastic, most commonly polyethylene. Plastic tubes are used for cosmetics such as hand creams, and also some foodstuffs. The plastic tube retains its shape after each squeeze unlike laminate tubes such as toothpaste tubes. Plastic tubes can be highly decorated or... | milkshake721/2.1M-wiki-STEM |
Tube (container)-Applications-Many commodities are commonly sold in collapsible tubes: Toothpaste, formerly metal, now of plastic Viscous artists' paint, including oil paint, acrylic paint, and concentrated watercolor paints (which must be diluted with water); typically metal Pastes used in food, such as anchovy paste,... | milkshake721/2.1M-wiki-STEM |
Cab rank-Cab rank-A cab rank (in British English) or taxicab stand (in American English) is an area where taxicabs queue to await passengers. | milkshake721/2.1M-wiki-STEM |
Cab rank-Cab rank-Cab rank may also refer to: Bank (in Cockney rhyming slang) A flying reserve of fighter-bomber aircraft that can be called in to provide close air support (the term cab rank was used by the RAF during World War II) Cab-rank rule, the obligation in English law of a barrister to accept any work in a fie... | milkshake721/2.1M-wiki-STEM |
Blood-oxygen-level-dependent imaging-Blood-oxygen-level-dependent imaging-Blood-oxygen-level-dependent imaging, or BOLD-contrast imaging, is a method used in functional magnetic resonance imaging (fMRI) to observe different areas of the brain or other organs, which are found to be active at any given time. | milkshake721/2.1M-wiki-STEM |
Blood-oxygen-level-dependent imaging-Theory-Neurons do not have internal reserves of energy in the form of sugar and oxygen, so their firing causes a need for more energy to be brought in quickly. Through a process called the haemodynamic response, blood releases oxygen to active neurons at a greater rate than to inact... | milkshake721/2.1M-wiki-STEM |
Blood-oxygen-level-dependent imaging-Theory-In 1990, three papers published by Seiji Ogawa and colleagues showed that hemoglobin has different magnetic properties in its oxygenated and deoxygenated forms (deoxygenated hemoglobin is paramagnetic and oxygenated hemoglobin is diamagnetic), both of which could be detected ... | milkshake721/2.1M-wiki-STEM |
Blood-oxygen-level-dependent imaging-Criticism and limitations-Although most fMRI research uses BOLD contrast imaging as a method to determine which parts of the brain are most active, because the signals are relative, and not individually quantitative, some question its rigor. Other methods which propose to measure ne... | milkshake721/2.1M-wiki-STEM |
Blood-oxygen-level-dependent imaging-Criticism and limitations-The typical discarding of the low-frequency signals in BOLD-contrast imaging came into question in 1995, when it was observed that the "noise" in the area of the brain that controls right-hand movement fluctuated in unison with similar activity in the area ... | milkshake721/2.1M-wiki-STEM |
Blood-oxygen-level-dependent imaging-History-Its proof of concept of blood-oxygen-level-dependent contrast imaging was provided by Seiji Ogawa and Colleagues in 1990, following an experiment which demonstrated that an in vivo change of blood oxygenation could be detected with MRI. In Ogawa's experiments, blood-oxygen-l... | milkshake721/2.1M-wiki-STEM |
Defeasibility (linguistics)-Defeasibility (linguistics)-In the linguistic field of pragmatics, an inference is said to be defeasible or cancellable if it can be made to disappear by the addition of another statement, or an appropriate context. For example, sentence [i] would normally implicate [ii] by scalar implicatur... | milkshake721/2.1M-wiki-STEM |
Defeasibility (linguistics)-Defeasibility (linguistics)-ii: Alice has exactly three children.But the implicature can be cancelled by the modification in [ib]: ib: Alice has three children, and possibly more.Whereas conversational implicatures and presuppositions may be cancelled, an entailment may not be. For example, ... | milkshake721/2.1M-wiki-STEM |
Defeasibility (linguistics)-Explicit and contextual cancellation-Grice, the originator of the concept of implicature, draws a distinction between explicit and contextual cancellation. He calls an implicature p explicitly cancellable if it is possible to cancel it by adding a statement to the effect of "but not p" to th... | milkshake721/2.1M-wiki-STEM |
Alarplasty-Alarplasty-Alarplasty (or, less commonly, alaplasty) is a plastic surgery procedure in which a wedge of the wing of the nose is removed in order to alter the shape of the nostrils. Alarplasty may be used to increase or decrease the width of the nostrils, for either cosmetic or functional reasons. In humans i... | milkshake721/2.1M-wiki-STEM |
Bropirimine-Bropirimine-Bropirimine is an experimental drug with anti-cancer and antiviral properties. It is an orally effective immunomodulator and is being tried in bladder cancers. | milkshake721/2.1M-wiki-STEM |
Bropirimine-Synthesis-For the first step, the dianion from malonic acid half-ester is formed by treatment with butyllithium. Acylation of the anion with benzoyl chloride proceeds at the carbanion, which is more nucleophilic (because of the higher charge density). This tricarbonyl compound decarboxylates on acidificatio... | milkshake721/2.1M-wiki-STEM |
Polyphagia-Polyphagia-Polyphagia or hyperphagia is an abnormally strong, incessant sensation of hunger or desire to eat often leading to overeating. In contrast to an increase in appetite following exercise, polyphagia does not subside after eating and often leads to rapid intake of excessive quantities of food. Polyph... | milkshake721/2.1M-wiki-STEM |
Polyphagia-Etymology and pronunciation-The word polyphagia () uses combining forms of poly- + -phagia, from the Greek words πολύς (polys), "very much" or "many", and φᾰ́γω (phago), "eating" or "devouring". | milkshake721/2.1M-wiki-STEM |
Polyphagia-Underlying conditions and possible causes-Polyphagia is one of the most common symptoms of diabetes mellitus. It is associated with hyperthyroidism and endocrine diseases, e.g., Graves' disease, and it has also been noted in Prader-Willi syndrome and other genetic conditions caused by chromosomal anomalies. ... | milkshake721/2.1M-wiki-STEM |
Polyphagia-Polyphagia in diabetes-Diabetes mellitus causes a disruption in the body's ability to transfer glucose from food into energy. Intake of food causes glucose levels to rise without a corresponding increase in energy, which leads to a persistent sensation of hunger. Polyphagia usually occurs early in the course... | milkshake721/2.1M-wiki-STEM |
Lumbosacral trunk-Lumbosacral trunk-The lumbosacral trunk is nervous tissue that connects the lumbar plexus with the sacral plexus. It is formed by the union of parts of the fourth and fifth lumbar nerves and descends to join the sacral plexus. | milkshake721/2.1M-wiki-STEM |
Lumbosacral trunk-Anatomy-The lumbosacral trunk is formed by the union of the entire anterior ramus of lumbar nerve L5 and a part of L4. L4 first issues its branches to the lumbar plexus, then emerges from the medial border of the psoas muscle to unite with the anterior ramus of L5 just superior to the pelvic brim to f... | milkshake721/2.1M-wiki-STEM |
Lumbosacral trunk-Clinical significance-The lumbosacral trunk may be compressed by the fetal head during the second stage of labour. This causes some muscle weakness in the legs. A full recovery is usually expected. | milkshake721/2.1M-wiki-STEM |
Beta3-adrenergic agonist-Beta3-adrenergic agonist-The β3 (beta 3) adrenergic receptor agonist or β3-adrenoceptor agonist, also known as β3-AR agonist, are a class of medicine that bind selectively to β3-adrenergic receptors. | milkshake721/2.1M-wiki-STEM |
Beta3-adrenergic agonist-Beta3-adrenergic agonist-β3-AR agonists for the treatment of obesity and type 2 diabetes have been in developmental stages within many large pharmaceutical companies since the early 1990s without successfully delivering an anti-obesity product to the market. More recently pharmaceutical compani... | milkshake721/2.1M-wiki-STEM |
Beta3-adrenergic agonist-Medical Uses-In 2018 only one β3-AR agonist is approved by the European Medicines Agency (EMA) and the Food and drug Administration (FDA) as a medicine. The medicine is called Mirabegron and is used to treat OAB. | milkshake721/2.1M-wiki-STEM |
Beta3-adrenergic agonist-Medical Uses-Urinary bladder Mirabegron is a selective β3-AR agonist that affects the detrusor muscles of the urinary bladder. By stimulation of β3-AR the contraction of the smooth muscles of the bladder is decreased and the bladder can store more volume of urine at a given time. Mirabegron als... | milkshake721/2.1M-wiki-STEM |
Beta3-adrenergic agonist-Medical Uses-In 2018 two other β3-AR agonists are in clinical trials, vibegron and solabegron. Vibegron is in phase 3 clinical trial and is used to treat OAB. Solabegron is in phase 2b clinical trials to treat OAB in women and in phase 1 clinical trials in men to treat OAB.
Obesity and diabetes... | milkshake721/2.1M-wiki-STEM |
Beta3-adrenergic agonist-Medical Uses-Cardiovascular In March 2016 a study funded by the European Commission began. The study is assessing the efficacy of Mirabegron in prevention of heart failure. In 2018 the study is ongoing and it's expected to conclude in 2020.A selective β1-AR antagonist with additional β3-AR agon... | milkshake721/2.1M-wiki-STEM |
Beta3-adrenergic agonist-Mechanism of action-β3-AR are coupled with G proteins, both Gs protein and Gi protein. Gs protein coupled with β3-AR lead to increased activity of the enzyme adenylyl cyclase. Increased activity of adenylyl cyclase leads to increased formation of cyclic adenosine monophosphate (cAMP).β3-AR can ... | milkshake721/2.1M-wiki-STEM |
Beta3-adrenergic agonist-Mechanism of action-Nitric oxide Another mechanism by which β3-AR agonists exert their relaxative effects on vasculature is by promoting endothelial nitric oxide synthase (eNOS) activity and NO bioavailability. This is believed to be the mechanism by which nebivolol, a selective β1-AR antagonis... | milkshake721/2.1M-wiki-STEM |
Beta3-adrenergic agonist-Structure Activity Relationships (SAR)-Basic structure of β3-adrenergic receptor agonists β3-AR agonists have the basic structure 2-amino-1-phenylethan-1-ol but have variations that affect the selectivity of the agonist.
Binding to the β3-adrenergic receptor Visual inspection of selective β3-AR... | milkshake721/2.1M-wiki-STEM |
Beta3-adrenergic agonist-Structure Activity Relationships (SAR)-The basic structure of β-AR subtypes exhibit sequence similarity greater than 70% suggesting that the 3-dimensional structure of theses subtypes is similar. While the overall structure sequence is 70% identical the residue sites of the ligand binding pocke... | milkshake721/2.1M-wiki-STEM |
Beta3-adrenergic agonist-History of development-In 1984 the β3 receptor was described as the third group of beta receptors in adipose tissue. This led to the development of agonist targeted at obesity and diabetes. | milkshake721/2.1M-wiki-STEM |
Beta3-adrenergic agonist-History of development-In 1999 the function of the β3 in detrusor muscles was defined which opened the way for development of β3-AR agonist for OAB.In 2001 Mirabegron began clinical development in phase 1 clinical study. The indications were type 2 diabetes, lower urinary tract symptoms, OAB an... | milkshake721/2.1M-wiki-STEM |
Prime omega function-Prime omega function-In number theory, the prime omega functions ω(n) and Ω(n) count the number of prime factors of a natural number n. | milkshake721/2.1M-wiki-STEM |
Prime omega function-Prime omega function-Thereby ω(n) (little omega) counts each distinct prime factor, whereas the related function Ω(n) (big omega) counts the total number of prime factors of n, honoring their multiplicity (see arithmetic function). That is, if we have a prime factorization of n of the form n=p... | milkshake721/2.1M-wiki-STEM |
Prime omega function-Properties and relations-The function ω(n) is additive and Ω(n) is completely additive. ω(n)=∑p∣n1 If p divides n at least once we count it only once, e.g. 12 )=ω(223)=2 .Ω(n)=∑pα∣n1=∑pα∥nα If p divides n α≥1 times then we count the exponents, e.g. 12 )=Ω(2231)=3 . As usual, pα∥n means α... | milkshake721/2.1M-wiki-STEM |
Prime omega function-Properties and relations-It is known that the average order of the divisor function satisfies 2ω(n)≤d(n)≤2Ω(n) .Like many arithmetic functions there is no explicit formula for Ω(n) or ω(n) but there are approximations.
An asymptotic series for the average order of ω(n) is given by log log log ... | milkshake721/2.1M-wiki-STEM |
Prime omega function-Properties and relations-A partition-related exact identity for ω(n) is given by log 2[∑k=1n∑j=1k(∑d∣k∑i=1dp(d−ji))sn,k⋅|μ(j)|], where p(n) is the partition function, μ(n) is the Möbius function, and the triangular sequence sn,k is expanded by sn,k=[qn](q;q)∞qk1−qk=so(n,k)−se(n,k), in terms o... | milkshake721/2.1M-wiki-STEM |
Prime omega function-Continuation to the complex plane-A continuation of ω(n) has been found, though it is not analytic everywhere. Note that the normalized sinc function sinc sin (πx)πx is used.
log sinc (∏y=1⌈Re(z)⌉+1(x2+x−yz))) | milkshake721/2.1M-wiki-STEM |
Prime omega function-Average order and summatory functions-An average order of both ω(n) and Ω(n) is log log n . When n is prime a lower bound on the value of the function is ω(n)=1 . Similarly, if n is primorial then the function is as large as log log log n on average order. When n is a power of 2, then lo... | milkshake721/2.1M-wiki-STEM |
Prime omega function-Average order and summatory functions-Other sums relating the two variants of the prime omega functions include ∑n≤x{Ω(n)−ω(n)}=O(x), and log log log log x)1/2). | milkshake721/2.1M-wiki-STEM |
Prime omega function-Average order and summatory functions-Example I: A modified summatory function In this example we suggest a variant of the summatory functions := ∑n≤xω(n) estimated in the above results for sufficiently large x . We then prove an asymptotic formula for the growth of this modified summatory functi... | milkshake721/2.1M-wiki-STEM |
Prime omega function-Average order and summatory functions-The proof of this result follows by first observing that if is odd; if is even, and then applying the asymptotic result from Hardy and Wright for the summatory function over ω(n) , denoted by := ∑n≤xω(n) , in the following form: odd odd odd odd (x)+Sω(⌊x2⌋... | milkshake721/2.1M-wiki-STEM |
Prime omega function-Dirichlet series-A known Dirichlet series involving ω(n) and the Riemann zeta function is given by 1. | milkshake721/2.1M-wiki-STEM |
Prime omega function-Dirichlet series-We can also see that ∑n≥1zω(n)ns=∏p(1+zps−1),|z|<2,ℜ(s)>1, ∑n≥1zΩ(n)ns=∏p(1−zps)−1,|z|<2,ℜ(s)>1, The function Ω(n) is completely additive, where ω(n) is strongly additive (additive). Now we can prove a short lemma in the following form which implies exact formulas for the expans... | milkshake721/2.1M-wiki-STEM |
Prime omega function-Dirichlet series-Proof. We can see that ∑n≥1uf(n)ns=∏pprime(1+∑n≥1uf0(p,n)p−ns).
This implies that ∑n≥1f(n)ns=ddu[∏pprime(1+∑n≥1uf0(p,n)p−ns)]|u=1=∏p(1+∑n≥1p−ns)×∑p∑n≥1f0(p,n)p−ns1+∑n≥1p−ns=ζ(s)×∑pprime(1−p−s)⋅∑n≥1f0(p,n)p−ns, wherever the corresponding series and products are convergent. In the ... | milkshake721/2.1M-wiki-STEM |
Prime omega function-The distribution of the difference of prime omega functions-The distribution of the distinct integer values of the differences Ω(n)−ω(n) is regular in comparison with the semi-random properties of the component functions. For k≥0 , define := #({n∈Z+:Ω(n)−ω(n)=k}∩[1,x]).
These cardinalities have ... | milkshake721/2.1M-wiki-STEM |
Quantum tunnelling composite-Quantum tunnelling composite-Quantum tunnelling composites (QTCs) are composite materials of metals and non-conducting elastomeric binder, used as pressure sensors. They use quantum tunnelling: without pressure, the conductive elements are too far apart to conduct electricity; when pressure... | milkshake721/2.1M-wiki-STEM |
Quantum tunnelling composite-Introduction-QTCs were discovered in 1996 by technician David Lussey while he was searching for a way to develop an electrically conductive adhesive. Lussey founded Peratech Ltd, a company devoted to research work and usage of QTCs. Peratech Ltd. and other companies are working on developin... | milkshake721/2.1M-wiki-STEM |
Quantum tunnelling composite-Types-QTCs come in different forms and each form is used differently but has a similar resistance change when deformed. QTC pills are the most commonly used type of QTC. Pills are pressure sensitive variable resistors. The amount of electric current passed is exponentially proportionate to ... | milkshake721/2.1M-wiki-STEM |
Quantum tunnelling composite-Applications-In February 2008 the newly formed company QIO Systems Inc gained, in a deal with Peratech, the worldwide exclusive license to the intellectual property and design rights for the electronics and textile touchpads based on QTC technology and for the manufacture and sale of ElekTe... | milkshake721/2.1M-wiki-STEM |
Quantum tunnelling composite-Applications-The following are possible uses of QTCs: Sporting materials such as training dummies or fencing jackets can be covered in QTC material. Sensors on the material can relay information on the force of an impact.
Mirror and window operation such as gesture, stroke, or swipe can be ... | milkshake721/2.1M-wiki-STEM |
BAM15-BAM15-BAM15 is a novel mitochondrial protonophore uncoupler capable of protecting mammals from acute renal ischemic-reperfusion injury and cold-induced microtubule damage. | milkshake721/2.1M-wiki-STEM |
Interrogative word-Interrogative word-An interrogative word or question word is a function word used to ask a question, such as what, which, when, where, who, whom, whose, why, whether and how. They are sometimes called wh-words, because in English most of them start with wh- (compare Five Ws). They may be used in both... | milkshake721/2.1M-wiki-STEM |
Interrogative word-Interrogative word-For more information about the grammatical rules for using formed questions in various languages, see Interrogative. | milkshake721/2.1M-wiki-STEM |
Interrogative word-In English-Interrogative words in English can serve as interrogative determiners, interrogative pronouns, or interrogative adverbs. Certain pronominal adverbs may also be used as interrogative words, such as whereby or wherefore. | milkshake721/2.1M-wiki-STEM |
Interrogative word-In English-Interrogative determiner The interrogative words which, what, and whose are interrogative determiners when used to prompt the specification of a presented noun or noun phrase such as in the question Which farm is the largest? where the interrogative determiner which prompts specification o... | milkshake721/2.1M-wiki-STEM |
Interrogative word-In English-Interrogative pronoun The interrogative words who, whom, whose, what, and which are interrogative pronouns when used in the place of a noun or noun phrase. In the question Who is the leader?, the interrogative word who is a interrogative pronoun because it stands in the place of the noun o... | milkshake721/2.1M-wiki-STEM |
Interrogative word-In English-Interrogative adverb The interrogative words where, when, how, why, whether, whatsoever, and the more archaic whither and whence are interrogative adverbs when they modify a verb. In the question How did you announce the deal? the interrogative word how is an interrogative adverb because i... | milkshake721/2.1M-wiki-STEM |
Interrogative word-In English-Note, interrogative adverbs always describe auxiliary verbs such as did, do, should, will, must, or might. | milkshake721/2.1M-wiki-STEM |
Interrogative word-In English-Yes–no questions Yes–no questions can begin with an interrogative particle, such as: A conjugation of be (e.g. "Are you hungry?") A conjugation of do (e.g. "Do you want fries?") - see Do-support § In questions A conjugation of another auxiliary verb, including contractions (e.g. "Can't you... | milkshake721/2.1M-wiki-STEM |
Interrogative word-In English-These underwent further sound changes and spelling changes, notably wh-cluster reductions, resulting in the initial sound being either /w/ (in most dialects) or /h/ (how, who) and the initial spelling being either wh or h (how). This was the result of two sound changes – /hw/ > /h/ before ... | milkshake721/2.1M-wiki-STEM |
Interrogative word-In English-In how (Old English hū, from Proto-Germanic χwō), the w merged into the lave of the word, as it did in Old Frisian hū, hō (Dutch hoe "how"), but it can still be seen in Old Saxon hwō, Old High German hwuo (German wie "how"). In English, the gradual change of voiceless stops into voiceless ... | milkshake721/2.1M-wiki-STEM |
Interrogative word-In English-The words who, whom, whose, what and why, can all be considered to come from a single Old English word hwā, reflecting its masculine and feminine nominative (hwā), dative (hwām), genitive (hwæs), neuter nominative and accusative (hwæt), and instrumental (masculine and neuter singular) (hwȳ... | milkshake721/2.1M-wiki-STEM |
Interrogative word-In English-The Proto-Indo-European root also directly originated the Latin and Romance form qu- in words such as Latin quī ("which") and quando ("when"); it has also undergone sound and spelling changes, as in French qui "which", with initial /k/, and Spanish cuando, with initial /kw/. | milkshake721/2.1M-wiki-STEM |
Interrogative word-In English-Forms with -ever Most English interrogative words can take the suffix -ever, to form words such as whatever and wherever. (Older forms of the suffix are -so and -soever, as in whoso and whomsoever.) These words have the following main meanings: As more emphatic interrogative words, often e... | milkshake721/2.1M-wiki-STEM |
Interrogative word-In English-To form adverbial clauses with the meaning "no matter where/who/etc.": Wherever they hide, I will find them.Some of these words have also developed independent meanings, such as however as an adverb meaning "nonetheless"; whatsoever as an emphatic adverb used with no, none, any, nothing, e... | milkshake721/2.1M-wiki-STEM |
Interrogative word-Other languages-A frequent class of interrogative words in several other languages is the interrogative verb: Korean: Mongolian: Australian Aboriginal languages Interrogative pronouns in Australian Aboriginal languages are a diverse set of lexical items with functions extending far beyond simply the ... | milkshake721/2.1M-wiki-STEM |
Tetramethylammonium pentafluoroxenate-Tetramethylammonium pentafluoroxenate-Tetramethylammonium pentafluoroxenate is the chemical compound with the formula N(CH3)4XeF5. The XeF−5 ion it contains was the first example of a pentagonal planar molecular geometry AX5E2 species. It was prepared by the reaction of N(CH3)4F wi... | milkshake721/2.1M-wiki-STEM |
Felicity effect-Felicity effect-The Felicity effect in Physics, is an effect observed during acoustic emission in a structure undergoing repeated mechanical loading. It negates the effect of emission silence in the structure that is often observed from the related Kaiser effect at high loads. A material demonstrating ... | milkshake721/2.1M-wiki-STEM |
Do3D-Do3D-Do3D was one of the first virtual reality computer software released for Microsoft Windows, being the first consumer product released by Superscape in 1998.
The purpose of the program was the ability to create your own virtual worlds, having the feature to implement them onto webpages with special plug-ins, a... | milkshake721/2.1M-wiki-STEM |
SwitchUp-SwitchUp-SwitchUp is an online coding and computing programing platform. Students use the website to research online and offline programming courses by reading alumni reviews, connecting with mentors in the forum, taking an online quiz, and reading industry studies. SwitchUp only accepts reviews from verified ... | milkshake721/2.1M-wiki-STEM |
SwitchUp-History-SwitchUp, was started after Jonathan Lau, an MIT alum, attended a Coding Bootcamp in Boston. He launched SwitchUp with a small team, and left the first code bootcamp review on the site.
SwitchUp aims to add transparency to the technology education industry. The website was launched in August 2014. | milkshake721/2.1M-wiki-STEM |
SwitchUp-Product-As of October 2020, the site had over 20,000 reviews of 1000 different programming bootcamps and courses across 30 different countries. Switch guides students on a career path, recommends bootcamps, and aggregates alumni reviews. | milkshake721/2.1M-wiki-STEM |
SwitchUp-Research Publications and Rankings-SwitchUp regularly publishes industry research and bootcamp rankings. They also put out data science, cyber security, and web design rankings. | milkshake721/2.1M-wiki-STEM |
SwitchUp-Research Publications and Rankings-They also offer scholarship information and listings for bootcamps that accept the GI Bill.In a job outcomes study conducted by researchers published on Dec 1, 2016, the following trends were found: 63% of graduates reported increase in salary 80% of graduates reported they w... | milkshake721/2.1M-wiki-STEM |
Bartter syndrome-Bartter syndrome-Bartter syndrome (BS) is a rare inherited disease characterised by a defect in the thick ascending limb of the loop of Henle, which results in low potassium levels (hypokalemia), increased blood pH (alkalosis), and normal to low blood pressure. There are two types of Bartter syndrome: ... | milkshake721/2.1M-wiki-STEM |
Bartter syndrome-Signs and symptoms-In 90% of cases, neonatal Bartter syndrome is seen between 24 and 30 weeks of gestation with excess amniotic fluid (polyhydramnios). After birth, the infant is seen to urinate and drink excessively (polyuria, and polydipsia, respectively). Life-threatening dehydration may result if t... | milkshake721/2.1M-wiki-STEM |
Bartter syndrome-Signs and symptoms-Bartter syndrome consists of low levels of potassium in the blood, alkalosis, normal to low blood pressures, and elevated plasma renin and aldosterone. Numerous causes of this syndrome probably exist. Diagnostic pointers include high urinary potassium and chloride despite low serum v... | milkshake721/2.1M-wiki-STEM |
Bartter syndrome-Pathophysiology-Bartter syndrome is caused by mutations of genes encoding proteins that transport ions across renal cells in the thick ascending limb of the nephron also called as the ascending loop of Henle. Specifically, mutations directly or indirectly involving the Na-K-2Cl cotransporter are key. T... | milkshake721/2.1M-wiki-STEM |
Bartter syndrome-Diagnosis-People with Bartter syndrome present symptoms that are identical to those of patients who are on loop diuretics like furosemide, given that the loop diuretics target the exact transport protein that is defective in the syndrome (at least for type 1 Bartter syndrome). The other subtypes of the... | milkshake721/2.1M-wiki-STEM |
Bartter syndrome-Diagnosis-Abuse of diuretic medications (water pills): The physician must screen urine for multiple diuretics before a diagnosis is made.
Magnesium deficiency and calcium deficiency: These patients will also have low serum and urine magnesium and calcium.Patients with Bartter syndrome may also have ele... | milkshake721/2.1M-wiki-STEM |
Bartter syndrome-Diagnosis-Related conditions Bartter and Gitelman syndromes are both characterized by low levels of potassium and magnesium in the blood, normal to low blood pressure, and hypochloremic metabolic alkalosis.However, Bartter syndrome is also characterized by high renin, high aldosterone, hypercalciuria, ... | milkshake721/2.1M-wiki-STEM |
Bartter syndrome-Diagnosis-Pseudo-Bartter's syndrome is a syndrome of similar presentation as Bartter syndrome but without any of its characteristic genetic defects. Pseudo-Bartter's syndrome has been seen in cystic fibrosis, as well as in excessive use of laxatives. | milkshake721/2.1M-wiki-STEM |
Bartter syndrome-Treatment-Medically supervised sodium, chloride and potassium supplementation is necessary, and spironolactone can be also used to reduce potassium loss. Free and unqualified access to water is necessary to prevent dehydration, as patients maintain an appropriate thirst response. In severe cases where ... | milkshake721/2.1M-wiki-STEM |
Bartter syndrome-Prognosis-The limited prognostic information available suggests that early diagnosis and appropriate treatment of infants and young children with classic Bartter Syndrome may improve growth and perhaps intellectual development. On the other hand, sustained hypokalemia and hyperreninemia can cause progr... | milkshake721/2.1M-wiki-STEM |
Bartter syndrome-History-The condition is named after Dr. Frederic Bartter, who, along with Dr. Pacita Pronove, first described it in 1960 and in more patients in 1962. | milkshake721/2.1M-wiki-STEM |
Václav Chvátal-Václav Chvátal-Václav (Vašek) Chvátal (Czech: [ˈvaːtslaf ˈxvaːtal]) is a Professor Emeritus in the Department of Computer Science and Software Engineering at Concordia University in Montreal, Quebec, Canada, and a visiting professor at Charles University in Prague. He has published extensively on topics ... | milkshake721/2.1M-wiki-STEM |
Václav Chvátal-Biography-Chvátal was born in 1946 in Prague and educated in mathematics at Charles University in Prague, where he studied under the supervision of Zdeněk Hedrlín. He fled Czechoslovakia in 1968, three days after the Soviet invasion, and completed his Ph.D. in Mathematics at the University of Waterloo, u... | milkshake721/2.1M-wiki-STEM |
Václav Chvátal-Research-Chvátal first learned of graph theory in 1964, on finding a book by Claude Berge in a Pilsen bookstore and much of his research involves graph theory: His first mathematical publication, at the age of 19, concerned directed graphs that cannot be mapped to themselves by any nontrivial graph homom... | milkshake721/2.1M-wiki-STEM |
Václav Chvátal-Research-A 1972 paper relating Hamiltonian cycles to connectivity and maximum independent set size of a graph, earned Chvátal his Erdős number of 1. Specifically, if there exists an s such that a given graph is s-vertex-connected and has no (s + 1)-vertex independent set, the graph must be Hamiltonian. A... | milkshake721/2.1M-wiki-STEM |
Václav Chvátal-Research-In a 1972 conjecture that Erdős called "surprising" and "beautiful", and that remains open (with a $10 prize offered by Chvátal for its solution) he suggested that, in any family of sets closed under the operation of taking subsets, the largest pairwise-intersecting subfamily may always be found... | milkshake721/2.1M-wiki-STEM |
Václav Chvátal-Research-In 1979, he studied a weighted version of the set cover problem, and proved that a greedy algorithm provides good approximations to the optimal solution, generalizing previous unweighted results by David S. Johnson (J. Comp. Sys. Sci. 1974) and László Lovász (Discrete Math. 1975).Chvátal first b... | milkshake721/2.1M-wiki-STEM |
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