accession
stringlengths
6
10
name
stringlengths
6
11
Full Name
stringlengths
1
147
taxon
stringlengths
3
46
sequence
stringlengths
16
2.75k
function
stringlengths
6
5.51k
AlphaFoldDB
stringlengths
6
10
Q1JHN8
ATPD_STRPD
F-type ATPase subunit delta
Streptococcus
MTKKEQALIEQYAKSLVEVASEHHSLDALQADVLAILETFVTTNLDQSLSSLAVPHAEKIKLLTLLKGSNSVYMNNFLNLILQNEREAYLYQMLQTVLNEIAIVSNQYDVTVTSSLPLTEEQKSRVRAVVAKKFAVTAGRLIEKVDPSLIGGFIISVNNKVIDTSIRRQLQAFKMNLK
This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
Q1JHN8
A4SP04
RLMN_AERS4
tRNA m2A37 methyltransferase
Aeromonas
MMSEIKTNLLDLDRDAMRAFFVELGEKPFRADQIMKWIYHFGCDDFDQMNNVNKVLRERLKAIAEIRAPEVSREQRSSDGTIKWALQVGGQEVETVYIPEEDRATLCVSSQVGCALACKFCSTAQQGFNRNLKVSEIIGQVWRAAKIVGGKRPITNVVMMGMGEPLLNLANVIPAMRLMMDDFGYGISKRRVTISTSGVVPALDILGDQIDVALAISLHAPNDKLRSEIMPINDKYNIEDFLAGVRRYLAKSNANGGRVTVEYVLLDHINDDMQHAHELAKVLKDTPSKINLIPFNPFPGNPYGKPSNSRIDRFSKVLMEYGFTVIVRKTRGDDIDAACGQLVGEVIDRTKRTMKNRMQQDGISVKMV
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
A4SP04
E5AE43
RTA1_LEPMJ
Phomenoic acid biosynthesis cluster protein RTA1
Leptosphaeria maculans species complex
MNAYAYTACLGIYGSTPNNEQLVLGSPDQLQRNKPRFRLIVLPHAPAASPFYPPWRSFAPDWEGQGARPMDHFKVGNLRFQLETHRIDEHSTFGKLFGHAPSPSQSCVSFQKKSDRAEPLLLARCSAASWSCIHPPTVLYFVAYQLEYPFAARFSATKISPIQDKMVATSDVPIVGSLYVYAPNKGAPIFFTIAFAISTILHSWQCHRYKAWKLIWLQPACAALFTLGYALREYGAYNYLYDGTEKAPLALFILSQICIYLGPPLLELANYHILGRVFHYVPYAAPFNPGRVTAFFGGLMAIVEGLSGSGVSLTANAKAKESTKKTGHNLLLVALALQVCVIFIFVYLSVLFHRRCIKAKVPAQSKAVKSTLMTLYLSMALIFIRCVFRLVEMATSSTSVDITSMERLMKLSPVLRNEAYFYAFEASLMLINSFLWNVQHPGPHLPGDTHIYLAQDGTEVEGEGDGSEDRPLLLNMANTLMFGLLYRDDKDHTHSQPQELYENPNGNGHKKFRLGNGGRAT
Lipid-translocating exporter-like protein; part of the gene cluster that mediates the biosynthesis of phomenoic acid, a long chain aliphatic carboxylic acid that does not appear to be essential for pathogenicity but may play a role in allowing to outcompete other fungi in the environmental niche via its antifungal properties.
E5AE43
P0CU75
CLAC_PASFU
Cladofulvin biosynthesis cluster protein C
Fulvia
MAVVNGNYIPGRLDGRVAVVTGSGRGIGAAIAVHLGRLGANIVVNYANSALDAQKVVDQIKGAGSEAIAIKADIRDVSQIMRLFDEAVAHFGHVDIAVSNSGVVSFGHLKDVTEEEFDRVFSLNTRGQFFVAREAYRHLSEGGRIIMTSSNTSKDFSVPRHSLYSGSKGAVDSFVRIFSKDCGDKKITVNGVAPGGTVTDMFHDVSHHYIPDGEKYTAEQRQQMAAFASPLHRNGFPEDIANVVGFLASKEGEWINGKVINLDGGAA
Non-reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of the bianthraquinone cladofulvin, a conidial pigment not required for virulence but that plays a role in fitness and resistance to environmental stresses including UV light and low-temperature stress . The pathway begins with the synthesis of atrochrysone thioester by the polyketide synthase (PKS) claG. The atrochrysone carboxyl ACP thioesterase claF then breaks the thioester bond and releases the atrochrysone carboxylic acid from claG . This compound is decarboxylated by claH to yield emodin, which is further converted to chrysophanol hydroquinone by the reductase claC and the dehydratase claB . The cytochrome monooxygenase P450 claM then catalyzes the dimerization of nataloe-emodin to cladofulvin .
P0CU75
Q87KE2
TSAC_VIBPA
tRNA threonylcarbamoyladenosine biosynthesis protein TsaC
Vibrio
MDNFEQVLNALQQGEVIAYPTEGVFGVGCDPDNPDAIQKLLDLKQRPVEKGLILIAASYEQLLPYIDESQLTPEQLATVHATWPGPYTWIMPASDKVSNWVSGQFDSIAVRVTDHPLVQKMCNAFGKPLTSTSANLSGLPPCMTTEEVEQQLGDKLVAILRGETSGRDKPSEIRDAKTSQILRQG
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate.
Q87KE2
Q8FQ20
ATPB_COREF
F-ATPase subunit beta
Corynebacterium
MTTALTEQNAQQAATAGRVVRVIGAVVDVEFPRGELPALYNALTAEVTLESVAKTVVLEVAQHLGDNLIRTIAMAPTDGMVRGATVTDTGKPISVPVGDVVKGHVFNALGDCLDVPGLGRDGEQWGIHREPPSFDQLEGKTEILETGIKVIDLLTPYVKGGKIGLFGGAGVGKTVLIQEMITRIAREFSGTSVFAGVGERTREGTDLFLEMEEMGVLQDTALVFGQMDEPPGVRMRVALSGLTMAEYFRDVQNQDVLLFIDNIFRFTQAGSEVSTLLGRMPSAVGYQPTLADEMGVLQERITSTKGRSITSLQAVYVPADDYTDPAPATTFAHLDATTELDRSIASKGIYPAVNPLTSTSRILEPSIVGERHYEVSQRVIGILQKNKELQDIIAILGMDELSEEDKITVARARRLERFLGQNFFVAEKFTGLPGSYVPLADTIDAFERICNGDFDHYPEQAFNGLGGLDDVEAAYKKLTGK
Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.
Q8FQ20
P44643
RLMD_HAEIN
23S rRNA(m5U1939)-methyltransferase
Haemophilus
MVLLYTPKQKTKNVQTITADILDLDYQGLGVAKINGKTWFIENALPHEKVECRILEDKRQYGHAIVKKWRVKSPERLEPKCAHFMRCGGCQGQHIPIEMQRKAKESALFKRLSKLQSEPISFQPMICGDAWAYRRRVRLSLWFNPSTKQIEMGFRQKNTNDLIPVQSCEVAEPAINYLLPKLTALLEKFSAPKQLGHIELVAADNGVAMLLRYTKNLAEIDRTLLLKFAEQEKLMLFLQSDKGIEQIYGDAPYYQFSDGIKLHFDIRDFIQVNSALNEPMVNTALDWLELSQQDCVLDLFCGMGNFTLPLAKRVKSAVGIEGVFEMVQKAAQNAERNQIKNIEFFQADLDQSFVEQPWANQSFNKILLDPPRSGAAFALNALCELKAEKILYVSCNPATLVRDAEILCNFGYKIEKSAVIDMFPHTGHLESITLFTTK
Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA.
P44643
B8MLU5
LIPA_TALSN
Lipoic acid synthase
Talaromyces sect. Talaromyces
MAASSTRLRCLYASSAPAWKKSPSQSIISLSRHYATTSSTTPSLNPDESSSSSSSTIPKRRKTTTFRDKLNAGPSFADFVTGGNGNNASLDPEEAYALEKVMIPGPAGRKKEHTRLPSWLKTPIPDSTNYKRIKKDLRGLDLHTVCEEARCPNISDCWGGSDKSAATATIMLMGDTCTRGCRFCSVKTLRTPGPLDPHEPENTAEALSRWGLGDDLPDGGAHHFAETVIKIKQKAPGILVECLTGDFAGDLDMVSLVAKSGLDVYAHNVETVEALTPHVRDRRATFKQSLRVLEAAKRAKPSLITKTSMMLGFGETEDQLWDALRQLRASNVDVVTFGQYMRPTKRHMAVHEYVTPDKFELWRQRALEMGFLYVASGPLVRSSYKAGEAFIENVLKKRRGVGNTPGAEVASAKDVPVDVLGK
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
B8MLU5
Q12FJ6
COBS_POLSJ
Cobalamin-5'-phosphate synthase
unclassified Polaromonas
MNPISQFVREYLLAVQFFTRIPVVGRLADWVGYSPELLRASAGHFPGVGILVGVMAALVYGLIQALLPNTPFTPLVAAVLSTAATVLLTGGFHEDGLADVADGLGGSQDRERALEIMKDSRVGAFGAMALMLALLGKTALLAMLGSVDVSPAELGDDASFSSWYIGAALLTGHVVSRGLPLLLIWLLPHVGNTASSKSKPLADQISQGSLLVAFIWSFVVLALAGLALDAISLIVACSFSLLALLWMGALFKRRLQGFTGDCLGATQQVCEIAFYLGLAVSL
Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
Q12FJ6
P70617
NINJ1_RAT
Secreted ninjurin-1
Rattus
MDPGTEEYELNGDLRPGSPGSPDASPPRWGLRNRPINVNHYANKKSAAESMLDIALLMANASQLKAVVEQGNEFAFFVPLVVLISISLVLQIGVGVLLIFLVKYDLNNPAKHAKLDFLNNLATGLVFIIVVVNIFITAFGVQKPVMDVAPRQ
Secreted form generated by cleavage, which has chemotactic activity. Acts as an anti-inflammatory mediator by promoting monocyte recruitment, thereby ameliorating atherosclerosis.
P70617
Q0ADI8
RS18_NITEC
30S ribosomal protein S18
Nitrosomonas
MANRPLFKRKKFCRFTAEGIKKIDYKDVDLLKDFISENGRIIPARITGTRSYYQRQLNLAIERARFLALLPYTDQH
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
Q0ADI8
A1KS00
RNPA_NEIMF
Protein C5
Neisseria
MDYRFGRQYRLLKTDDFSSVFAFRNRRSRDLLQVSRSNGNGLDHPRIGLVVGKKTAKRANERNYMKRVIRDWFRLNKNRLPPQDFVVRVHRKFDRSTAKQARAELAQLMFGNPATGCRKQA
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
A1KS00
Q31KZ4
PSBZ_SYNE7
Photosystem II reaction center protein Z
Synechococcus
MVILFQLALLLLVVMSFVLIVGVPVLYATNGDRVQSNRLILVGGLAWTALVVLVGVLNYFVV
Controls the interaction of photosystem II (PSII) cores with the light-harvesting antenna.
Q31KZ4
Q91ZP9
NECA2_MOUSE
Neuronal calcium-binding protein 2
Mus
MCERAARLCRAGAHRLLREPPPQGRALGGLLRWVGARMGEPRAPLVPDIPSADPGPGPAASRGGTAVILDIFRRADKNDDGKLSLEEFQLFFADGVLNEKELEGLFHTIDSDNTNHVDTKELCDYFVEHMGDYEDVLASLETLNHSVLKAMGYTKKVYEGGSNVDQFVTRFLLKETANQIQSLLSSVESAVEAIEEQTSQIRQDHCKPSHAVNESRYGGPTPPYIPNHKLVAPEPMKSLPVATGEPKEDGLEGQISRLAELIGRLESKTLSFDLQQRLSDEEGTNMHLQLVRQEMAVCPEQLSEFLDSLRQYLRSTAEERNCFHVAAVRMADGLTFVIYEFWETEEEWKRHLQSPVCKAFRHVKVDTLSQPEALSQISVPAAWCTSGRD
May act as a signaling scaffold protein that senses intracellular calcium. Can modulate ligand-induced internalization of ADORA2A and coupling efficiency of mGluR5/GRM5; for both receptors may regulate signaling activity such as promoting MAPK1/3 (ERK1/2) activation.
Q91ZP9
Q54JH6
CMT1_DICDI
DNA (cytosine-5)-methyltransferase
Dictyostelium
MEQLRVLEFYSGIGGMHYGLQESGVDFQVIQSFDINTNANLNYKYTFNEDSSQKSIESYSVEELEGFKANAWLMSPPCQPFTRLGLQKDDQDNRTNSFFHLLDVLTKIKDPPTYILIENVFGFAKKGSSNTRDHLLDTLIKMNYSFQEFHLSPQQFGLANQRLRYFCIAKRNGKLNFKKEQDKHNEKVDENKLNNNSNNNNEQNKYDNLKILDHIPGYDFHTTLEECDEISNYFDKDLTDDELYEKYKVPHNLLLSKGMLFDIKQKDSKTSNCVTKSYGKFIEGTGSIIQMDNNFKADINDNKSLIPLKLRYFSPKEITRLHGFPEEFKFSPKLTTIQCYRLIGNSLNVKIVSELLKVLVSPNEEEEQQEQQKEKEGKK
Involved in epigenetic gene silencing. Methylates specific cytosine residues in the retrotransposons DIRS-1 and Skipper.
Q54JH6
C3PL50
GLMM_CORA7
Phosphoglucosamine mutase
Corynebacterium
MTRLFGTDGVRGLANKKLTPILALRLGQAAAEVLTSDRESYERRPLAIIGRDPRVSGEMLDAAIASGLASRGVDVVRVGVLPTPAIAFLTDDFGADLGVMISASHNPMPDNGIKFFSAGGKKLPDEVEDRIQAAMDNLTEDGPTATKIGRIISEAPDGRERYLKHLAEVVTTDLSGIKVVVDTANGAASKVAPQAYEAAGAEVVAIHNKPNAFNINEDCGSTHIEKTQEAVVEHGADLGLAHDGDADRCLAVDAEGNVVDGDQIMAILAVGMKEENDLRFNTLVATVMSNLGLKLAMQEQGIDIKETAVGDRYVLEELNRGDFSLGGEQSGHVVLPDDCTTGDGTLTGLSIMARMAKSGKSLKELASVMTVLPQVLINVPVSDKAVILNAPEVKEAIAAAEAELGETGRVLLRPSGTEELFRVMVEAAEKEQARKVAGKLAAVVAAV
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
C3PL50
P81655
RK1_RABIT
Corticostatin-related peptide RK-1
Oryctolagus
MPCSCKKYCDPWEVIDGSCGLFNSKYICCREK
Has antimicrobial activity against E.coli and activates ion channel activity.
P81655
P54685
CDK7_DICDI
MO15 homolog
Dictyostelium
MDKYNIEALIGEGTYGVVSRATVKATGQIVAIKKIRKILIQNQTDDGINFSAIREIKILQELKHDNVVNLLDIFAHKSNVYLVFELMQWDLQEVIEDKSIILKPADIKSYMKMLLQGIEACHRNWVLHRDLKPNNLLMSINGDLKLADFGLARQYGSPNKVFSPQAVTIFYRAPELLFGAKSYGPSVDIWSIGCIFAELMLRTPYLPGTGEIDQLRKICSALGTPNESNWPGVTCLPNYIKFTDHPATPFKQLFTAASDEAIDLISKMLLFNPSNRISAADALNHPYFTSGVKHTNPADLPVPFAKKASLLQQRQVLAQVQQQLLQKQQQQQQQQQQQIQSQPEPIQVDNVEQTQQAQQV
Catalytic part of CAK which activates cyclin-associated CDK1/CDK2/CDK4 by threonine phosphorylation, thereby allowing MPF activation.
P54685
P23321
PSBO1_ARATH
OEC 33 kDa subunit
Arabidopsis
MAASLQSTATFLQSAKIATAPSRGSSHLRSTQAVGKSFGLETSSARLTCSFQSDFKDFTGKCSDAVKIAGFALATSALVVSGASAEGAPKRLTYDEIQSKTYMEVKGTGTANQCPTIDGGSETFSFKPGKYAGKKFCFEPTSFTVKADSVSKNAPPEFQNTKLMTRLTYTLDEIEGPFEVASDGSVNFKEEDGIDYAAVTVQLPGGERVPFLFTVKQLDASGKPDSFTGKFLVPSYRGSSFLDPKGRGGSTGYDNAVALPAGGRGDEEELVKENVKNTAASVGEITLKVTKSKPETGEVIGVFESLQPSDTDLGAKVPKDVKIQGVWYGQLE
Stabilizes the manganese cluster which is the primary site of water splitting.
P23321
Q971T0
IF5A_SULTO
eIF-5A
Sulfurisphaera
MSIQYTTVGDLKVGNYVVIDGEPCRVVEISKAKTGKHGSAKANIVAIGLFTGQKRTLMAPVDQQVEVPIIEKHIGQILADKGDTITIMDMENYETFDIEKPTDADIVDKIRPGAEVEYWEIMGRKKIVRVK
Functions by promoting the formation of the first peptide bond.
Q971T0
A5II94
TATA_LEGPC
Sec-independent protein translocase protein TatA
Legionella
MGLSGISPLSLLLILAIIVALFGTSKLKTIGSDLGEAIKNFRKAMNSEETNDTQKDDHKPL
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
A5II94
A5JZQ2
RU1C_PLAVS
U1 small nuclear ribonucleoprotein C
Plasmodium (Plasmodium)
MPKYYCEYCDIYLTHSSPVGRRQHIQGRKHISAKIEYFQNLLREEGITPQNFLGFLGNRAFNNMLGNPMMNNMMPGNFPMHMKHGGMKHHSHYSRHSHRHHMSHGRYNRERHGHHSYSSKYHSHPMHMNSNSIGNPSGFSNGKYSGSFFSSPNAMHGNGKMFNNTIRDLVSNVNIDSDPVKDSQNGERVGDNAIDKVSSGMHDQGDRGDLGDHADHADHAGPVSATDGTANGNDQVSVDA
Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
A5JZQ2
Q4WQU0
SED4_ASPFU
Sedolisin-D
Aspergillus subgen. Fumigati
MLSSTLYAGWLLSLAAPALCVVQEKLSAVPSGWTLIEDASESDTITLSIALARQNLDQLESKLTTLATPGNPEYGKWLDQSDIESLFPTASDDAVLQWLKAAGITQVSRQGSLVNFATTVGTANKLFDTKFSYYRNGASQKLRTTQYSIPDHLTESIDLIAPTVFFGKEQNSALSSHAVKLPALPRRAATNSSCANLITPDCLVEMYNLGDYKPDASSGSRVGFGSFLNESANYADLAAYEQLFNIPPQNFSVELINRGVNDQNWATASLGEANLDVELIVAVSHPLPVVEFITGGSPPFVPNADEPTAADNQNEPYLQYYEYLLSKPNSHLPQVISNSYGDDEQTVPEYYARRVCNLIGLMGLRGITVLESSGDTGIGSACMSNDGTNKPQFTPTFPGTCPFITAVGGTQSYAPEVAWDGSSGGFSNYFSRPWYQSFAVDNYLNNHITKDTKKYYSQYTNFKGRGFPDVSAHSLTPYYEVVLTGKHYKSGGTSAASPVFAGIVGLLNDARLRAGKSTLGFLNPLLYSILAEGFTDITAGSSIGCNGINPQTGKPVPGGGIIPYAHWNATAGWDPVTGLGVPDFMKLKELVLSL
Secreted tripeptidyl-peptidase which degrades proteins at acidic pHs and is involved in virulence.
Q4WQU0
Q4V7H8
BORE2_XENLA
Dasra-A
Xenopus
MPPKRNRNRLGTRGEGSGDSGVGMFERNDAVQEHKKEKIRLFMQDFVQQGKDRLAELKKDLESLSTTADKALEVELLKMPLAIRHMKVQDYLSLMGGDKSAVAAAAVKLDCSVDELSEPKLVRKNSKKVKVTTNVEYQDDVRTKVMTTSTKNRTVQKVPKSKSMLSLTGKNGKKTTALTRSVSATPLDKASKKLLVTNSSSKPAQRSSRTAMTPLTRSARSDTMFTFGDGAFLDEGVPFVKIPLADGKTVFSAGDDLDSLNVELLRGDTVQHIHNLVGQLTSLCAKASIQHHGNTL
Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Contributes to CPC function by facilitating loading of the CPC onto chromosomes.
Q4V7H8
O28359
RL22_ARCFU
50S ribosomal protein L22
Archaeoglobus
MPMARVNYAYKPEDETKAAKAMGYEMPISFKHAVEICRAIRGKKIEEARKLLEDVVEMKRAIPFKRHKKKVAHRRGLEKWYAGRYPQKAAKYVLKVLRNLEANAEYKGLDVENLVIVHAQAQKGRVIERYMPRAFGRATPRFQQLTTVELVAEVR
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
O28359
P84908
DAIP_STRMB
Dispase autolysis-inducing protein
Streptomyces
MKRMGWAVTAAVTTIVLAQSSLAAQAADSTSGWRAPSCTKVTGDGAVTFTTDDGATLAPTTGTLQSVSYTHGLVALDTPNTLLATHNDELQRSTDAGCTWTKVATLGSGSTWLTAATGGRAFAWEKNGGYLARVDGRTVTKLSSPSADIVGVGTDKARRDHVRLAGSDGQLYDSTDAGATWKPLGKLAFGPGASVYTVSFDPADLDHAVAGGMTTGGAVTTDGGATWTAATGLSATAGGKSNLFAASVSPADRNVVYALGIDLVEAAPNSGAEGRHLYRSTDGGRTYTRIVDDTPDTELTNSTLLAPSPVDPNVLYFEYGTYFQAYGTDLYRYDARTGKVGKTHNAHDGISAIAFNPARPSVMYLGLEEVQIHH
Induces autolysis of dispase and thermolysin.
P84908
P0DC94
PCP_STRP3
Pyroglutamyl-peptidase I
Streptococcus
MKILVTGFDPFGGEAINPALEAIKKLPATIHGAEIKCIEVPTVFQKSADVLQQHIESFQPDAVLCIGQAGGRTGLTPERVAINQDDARIPDNEGNQPIDTPIRVDGKAAYFSTLPIKAMVAAIHQAGLPASVSNTAGTFVCNHLMYQALYLVDKYCPNAKAGFMHIPFMMEQVVDKPNTAAMNLDDITRGIEAAIFAIVDFKDRSDLKRVGGATH
Removes 5-oxoproline from various penultimate amino acid residues except L-proline.
P0DC94
A9IK70
HFQ_BORPD
RNA-binding protein Hfq
Bordetella
MSNKGQTLQDPFLNTLRKEHVPVSIYLVNGIKLQGQIESFDQYVVLLRNTVTQMVYKHAISTVVPARAVNFQVDVPAE
RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs.
A9IK70
Q82DN0
RL18_STRAW
50S ribosomal protein L18
Streptomyces
MAYGVKIAKGDAYKRAAIKRRHIRIRKHISGTAERPRLVVTRSNRHIVAQVIDDVKGHTLASASTLDTTIRGGESDKSAQAKSVGALVAERAKAAGVEAVVFDRGGNQYAGRIAALADAAREAGLKF
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
Q82DN0
A6TGG8
GPPA_KLEP7
pppGpp-5'-phosphohydrolase
Klebsiella
MSSTSLYAAIDLGSNSFHMLVVREVAGSIQTLSRIKRKVRLAAGLNSDNTLSAEAMERGWQCLRLFAERLQDIPPTQIRVVATATLRLAVNAGEFLAKAQEILGTPVQVISGEEEARLIYQGVAHTTGGADQRLVVDIGGASTELVTGTGAQTTSLFSLSMGCVTWLERYFADRSLTKENFDLAEAAAREVLLPVADVLRYHGWKVCVGASGTVQALQEIMMAQGMDERITLAKLQQLKQRAIQCGRLEELEIEGLTLERALVFPSGLAILIAIFSELNIQCMTLAGGALREGLVYGMLHLSVEQDIRSRTLRNIQRRFMIDTEQAQRVGGLASHLLSQLDGSWELDPLSRDLLLSACALHEIGLSVDFKRAPQHAAYLVNNLDLPGFTPAQKKLIATLLLNQTNAIDLSSLHQQNAVPPRVAEHLCRLLRLAILFASRRRDDLLPAIQLTAQDEQLTLILPGNWLDEHPLGREMVDQECQWQSYVHWILRVASGDTLK
Catalyzes the conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the 'stringent response', an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities.
A6TGG8
B8D9V0
EFG_BUCA5
Elongation factor G
Buchnera
MSRTTPISRYRNIGISAHIDAGKTTTTERILFYTGINHKIGEVHDGAATMDWMEQEQERGITITSAATTTFWSGMAKQFKPHRINIIDTPGHVDFTIEVERSMRVLDGAVMVYCAVGGVQPQSETVWRQANKYNVPRIAFVNKMDRMGANFLKVVKQIKIRLGANPVPLQLAIGAEDTFVGVVDLIKMKAVHWKDSDQGVTFVYNDIPPEMIELSKKWNQNLIESAVESNEDLLEKYLNGDRLSESEIKSALRKRALNNEIVLITCGSAFKNKGVQALLDAIIEFLPAPNDIQDIKGILNDVEQTPAIRNSDDKAPFSALAFKIASDPFVGNLTFFRVYSGVVKSGDTVFNSAKSQRERFGRIVQMHANKREEIKEVYAGDIAAAIGLKDVTTGDTLCDLNDPIILERMEFPEPVISISVEPKTKVDQEKMGLALGRLAKEDPSFRVRTDQESNQTIISGMGELHLEIIIDRMKREFSVDANVGKPQVAYRETILNKVEDIEGKHIKQSGGRGQYGHVVIELFPLQPGGEGYLFVNDIKGGVIPSEYISAIDKGIQEQLKCGPLAGYPVVDIGVRLYFGSYHDVDSSELAFKLAASAAFKKGFKQAKPILLEPIMKVEVETPDDYMGDVIGDLNRRRGIIEGMKDLSISKIINACVPLSEMFGYATDLRSQTQGRASYSMEFLKYIEAPFNISKDIIERREK
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
B8D9V0
A1USC1
EFTU1_BARBK
Elongation factor Tu 1
Bartonella
MAKSKFERTKLHVNIGTIGHVDHGKTSLTAAITKYFGEFKAYDQIDAAPEERARGITISTAHVEYETDQRHYAHVDCPGHADYVKNMITGAAQMDGAILVVSAADGPMPQTREHILLARQVGVPAIVVFLNKVDQVDDAELLELVELEVRELLSKYDFPGDDIPIVKGSALAALEDSDKSIGEDAVRLLMSEVDRYIPTPERPVDQSFLMPIEDVFSISGRGTVVTGRVERGVVKVGEEIEIVGIRPTSKTTVTGVEMFRKLLDQGQAGDNIGALLRGIDREGIERGQVLAKPGSVTPHTKFKAEAYILTKDEGGRHTPFFTNYRPQFYFRTTDVTGIVTLPEGTEMVMPGDNVAMDVSLIVPIAMEEKLRFAIREGGRTVGAGIVSKIIE
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
A1USC1
Q8KQF5
COP_STAEP
Protein cop
Staphylococcus
MTFNKIFKYLISLLFLSILFHTIIHKNNLVFSKTMHKKVAFFSFSIFFVWIRHLKRYNSMLEKATFFVLQTSYTNELKGLYIAGNSYPYYQDKKKLVFNSFQKPFKNHQSTKIPRE
Putative control of replication message.
Q8KQF5
Q45374
KDTA_BORPT
Monofunctional Kdo transferase
Bordetella
MGRGVYTLALRGLAPLIWLWMWRRARRAGGQWELFAPARFGRAGARAPAPLAAPVWVHAVSLGETRAAQPLVQALLERGLPVLLTHTTATGRAEGERLFGAAIGRGQLQQAWLPYDFPGATRRFLARHAPRCGLLMEREVWPNLLAAARAQGVPMALVSARFSASSLRQAGWLGQALREALAGLDRVLAQTDEDGARLCQAGANAYTVTGSLKFDVALPEAQLRVGHAWAGATGRPVIALASTREGEDAMFIEAIGALQAHRAATPRPLILLIPRHPQRFDEAAAQLQAAGLAYARRSAGSGEPGPHIDVLLGDTLGEMPFYYAAADVAIVGGSFARLGGQNLIEACAAGTPVIVGPHTFNFKDAARDAIAAGAALRAPDARTALDWALQLLAEPARRQAMSEAARAWTAAHAGATRRTLDALEDWLG
Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of a single 3-deoxy-D-manno-octulosonate (Kdo) residue from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A.
Q45374
P43834
SYV_HAEIN
Valyl-tRNA synthetase
Haemophilus
MTQKFEMADRFNPSAVEQALYQRWEESGYFKPSENENAPSYCIAIPPPNVTGSLHMGHAFQQTLMDTLIRFNRMEGHNTLWQTGTDHAGIATQMVVERKIAAEEGKTRHDYGREAFINKIWDWKAYSGGTISQQMRRLGNSIDWERERFTMDDGLSNAVKEVFVRLHEEGLIYRGKRLVNWDPKLHTAISDLEVENKESKGSLWHFRYPLANDAKTADGKDYLVVATTRPETMLGDTAVAVHPEDERYQSLIGKTVVLPLANREIPIIADEYVDREFGTGVVKITPAHDFNDYEVGKRHNLPMVNVLTLNANIRDEAEIIGTDGKPLAGYEATIPADYRGLERFAARKKIVADFEALGLLDEIKPHDLKVPYGDRGGVPIEPMLTDQWYVSVKPLADVAIKAVEDGEIQFVPKQYENLYFSWMRDIQDWCISRQLWWGHRIPAWYDAEGNVYVARNEEEVRSKYNLDSAVELKQDEDVLDTWFSSGLWTFSTLGWPEQTKELKMFHPTDVLITGFDIIFFWVARMIMFTMHFVKDENGKPQVPFKTVYVTGLIRDEQGQKMSKSKGNVLDPIDMIDGISLEDLLEKRTGNMMQPQLAEKIAKATRKEFAEGIAAHGTDALRFTLAALASNGRDINWDMKRLEGYRNFCNKLWNASRFVLTNEKLDLSQGEIEFSLADRWIQSEFNRTVETFRSSLSQYRFDLCANAIYEFTWNQFCDWYLELTKPVFANGNAAQIRAASQTLVHVLEKLLRLAHPLIPFITEEIWQKVKGFVGITADSIMLQPFPQVEESGFDPEAEAEIEWLKEVIVAVRNIRAESNIAPSKGLDLLFRNLSAENAKILEKQTALLKAMAKLDNVQVLATNETAPLAVAKLVGNAELLVPMAGFINKEAELARLTKEIEKYQNEVKRIENKLSNEAFVAKAPEAVIAKEREKQAEYQSGLEKIQEQYKAIEAL
Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
P43834
Q7K284
CLP1_DROME
Crowded by cid
Sophophora
MSEDQGKDYTLESDSELRFEIEQKDAKVLVSLVSGFAELFGTELVKKKQYEFGVGAKVAIFTYQGCVLHVSGKMDVCYISKETPMVQYVNCHAALEQFRMEAEEKDRYGPVAMVVGPMDVGKSTLCRILLNYAVRVGRRPLYADLDVGQGSIAISGSVATILIERPANVEEGFAKTAPLVYHFGHKSPSGNSVLYNAVVSKMAEVTLQSLNSNKRTKSSGIIINTCGWVKGSGYAHLLHAAKAYGACAIFVLDQERLYNELLRDVPKGVHVVLLPKSGGVVERSKELRHEARDQRIKEYFYGNTRAPFYPFSFEVKFQDLRLYKIGAPPLPDSCMPIGMKAEDNKTKVVAVTPTPALIHHVLALSFAESVEDDVIGTNVAGFCCVTEVDMERQAVMLLSPQPRPLPPNALLLWSELQFMDNHT
Required for endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.
Q7K284
A5IIX7
TDXH_THEP1
Thioredoxin-dependent peroxiredoxin
Thermotoga
MEGRIPLIGEEFPRLEVKTTHGKKILPDDFRGKWFVLFSHPADFTPVCTTEFVAFQKRYDEFKKLNTELIGLSIDQVFSHIKWIEWIKEKLGVEIEFPVIADDLGEVSRRLGLIHPSKGTNTVRAVFIVDPNGIIRAIVYYPQEVGRNIDEILRAVRALQTSDEKGVAIPANWPSNELINDSVIVPPASSVEEARERLESKDFECYDWWFCYKKV
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.
A5IIX7
P62642
CHEB2_LEPIC
Putative protein-glutamate methylesterase/protein-glutamine glutaminase
Leptospira
MNYEAIVIGVSAGGINAMKTILPTLPTQFGIPIVIVQHIGARSDGEWFRILEKLCNIKIKEAEEKEEIKSGMVYVAPPNYHLLIEKDKTFSFSIGERVNFSRPSIDVLFETASEVYEDKLIGVILTGANSDGAQGLKKIKENGGLAVVQDPLTAEIALMPRSAIEATSVDYVLSLEKIAELFIRLDQNNLEQR
May be involved in chemotaxis.
P62642
Q5LGW6
RECF_BACFN
DNA replication and repair protein RecF
Bacteroides
MILKRISILNYKNLEQVELNFSAKLNCFFGQNGMGKTNLLDAVYFLSFCKSAGNPIDSQNIRHEQDFFVIQGFYEAMDGTPEEIYCGMKRRSKKQFKRNKKEYSRLSDHIGFIPLVMVSPADSELIAGGSDERRRFMDVVISQYDKEYLDALIRYNKALVQRNTLLKSEQPIEEELFLVWEEMMAQAGEVVFRKREAFISEFIPIFQSFYSYISQDKEQVGLTYESHARKASLLEVLKESRVRDKIMGYSLRGIHKDELNMLLGDFPIKREGSQGQNKTYLVALKLAQFDFLKRTGSTVPLLLLDDIFDKLDASRVEQIVKLVAGDNFGQIFITDTNREHLDRILYKVGSDYKMFRVESGAINEMEEKER
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.
Q5LGW6
B2J3K1
CYF_NOSP7
Cytochrome f
Nostoc
MRNVFRTARLTRSARAIVKTLLIAIATVTFYFTSDLALPQSAAAYPFWAQQTYPETPREPTGRIVCANCHLAAKVTEVEVPQSVLPDTVFKAIVKIPYDLSAQQVGADGSKVGLNVGAVLMLPEGFKIAPEDRISEELKEEIGDTAFQPYSEDKENVVIVGPLPGEQYQEIIFPVLSPNPATDKNIHFGKYSVHVGGNRGRGQVYPTGEKSNNSVYNASATGTITKIAKEEDADGNVKYLVNIQPESGDVVVDTVPLGPDLIVSEGQAVKTGDALTNNPNVGGFGQIDAEIVLQDSSRVKWMIAFVALVMLAQVMLVLKKKQVEKVQAAEMNF
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
B2J3K1
P94966
BIOB_METSK
Biotin synthase
unclassified Methylobacillus
MRDSVIDIRGLDRVQRARVQAKEEAPKRWSVDDIVALFELPFSDLMHRAQSVHRENFDPNGVQVSTLLSIKTGGCSEDCGYCPQAARYHTDVEKQDLHAAGRGTRSRVLPRRMRQPFCMAAWQPKQRDLEPVLAMIREVKAMGLETCATLGMLKDGQAEQLKEAGLDYYNHNLDTAPEYYGEVITTRTYQDRLDTLDRVREQDINVCCGGIIGMGESRVQRAGLLAQLANMERPPESVPDQLLTQVEGTPMYGMDELDPFEFVRTIAAARITMPQSFVRLSVGRQSMHEGIQALCFLAGANSIFYGEKLLTTGNPEAEADRKLFDKLGIHPL
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
P94966
Q8K9E5
METK_BUCAP
Methionine adenosyltransferase
Buchnera
MTEYLFTSESVSEGHPDKIADQISDALLDEIIKQDLKARVACETYVKTGMVLIGGEITTTAWVDVEEITRNTINNIGYINSETGFDANSCAVLSTIGKQSPDITQGVDRCNPLEQGAGDQGIIFGYATNETEVLMPAPITYAHLLVKKQSELRKKNILHWLRPDAKSQVTFKYKNGRIIGIDTVVFSTQHKESITQDVLKEAVMEEIIKPVLPNKWLTKNTKFFINPTGRFVIGGPMGDCGLTGRKIIVDTYGGMSRHGGGAFSGKDPSKVDRSAAYAARYVAKNIVAAGLADRCEIQLSYAIGIAEPTSIMIETFRTGKISNKSLINLVRNIFDLRPYGLIEMLDLLRPIYLNTAVYGHFGREEFPWEKLDKVDELLQ
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
Q8K9E5
A4VYR8
RPOA_STRS2
Transcriptase subunit alpha
Streptococcus
MIEFEKPTITKIDENKDYGRFVIEPLERGYGTTLGNSLRRVLLASLPGAAVTSIKIDGVLHEFDTVPGVREDVMQIILNIKGIAVKSYVEDEKKIELDVVGPAEVTAGDILTDSDIEIVNPDHYLFTIADGATFKAVLTVNSGRGYVPAEDNKKDDAPVGTLAVDSIYTPVKKVNYQVEPARVGSNDGFDKLTLEINTNGTIIPEDALGLSARILMEHLGLFTDLTEVAKSAEVMKEAEVASDDRMLDRTIEELDLSVRSYNCLKRAGINTVFDLTEKTEPEMMKVRNLGRKSLEEVKVKLADLGLGLKKDK
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
A4VYR8
P61885
RS10_PYRFU
30S ribosomal protein S10
Pyrococcus
MQKARIKIASTNVRSLDEVANQIKQIAERTGVRMSGPIPLPTKRIRITTRKSPDGEGSATFDRWELRVHKRLIDIEADERAMRQIMRIRVPEDVTIEIELIS
Involved in the binding of tRNA to the ribosomes.
P61885
Q9GLW7
PRDX5_CHLAE
Thioredoxin-dependent peroxiredoxin 5
Chlorocebus
MGLAGVCVLRRSAGYILGGAARQSVAATAAARRRSEGGWASGGVRSFSRAAAAMAPIKVGDAIPAVEVFEGEPGNKVNLAELFKGKKGVLFGVPGAFTPGCSKTHLPGFVEQAEALKAKGVQVLACLSVNDAFVTGEWGRAHKAEGKVRLLADPTGAFGKETDLLLDDSLVSIFGNRRLKRFSMVVQDGIVKALNVEPDGTGLTCSLAPSIISQL
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events.
Q9GLW7
B2V910
TSAD_SULSY
tRNA threonylcarbamoyladenosine biosynthesis protein TsaD
unclassified Sulfurihydrogenibium
MVVLGIETSCDDTSIAVYDSEKGIPSNVVTSQLIHAQFGGVYPEIAAREHTKNFLPVLDKALRDASITLSDIDAIATTFMPGLIVSLVAGVSGAKTLSFSLKKPLIPVHHIEAHIFANFITKEIEYPFLALVVSGGHTELILVKEFEDYIYLGGTLDDAVGEVYDKVARALGLGFPGGPLIDKLAKEGKEAIKFPRPLLNDEENKYNFSFSGLKSAVIREINKGIYKKEDITKSFQNAVVDVLVKKTVLACKEFGINRVVVAGGVSANSQLREEFLNIKDLEVHFPPMHLCTDNGAMVAYTGYKRFKEKGISVSLDFEAKARCRIDKFPQLLRSFHA
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.
B2V910
Q8FK37
CUSS_ECOL6
Sensor histidine kinase CusS
Escherichia
MVSKPFQRPFSLATRLTFFISLATIAAFFAFAWIMIHSVKVHFAEQDINDLKEISATLERVLNHPDETQARRLMTLEDIVSGYSNVLISLADSHGKTVYHSPGAPDIREFTRDAIPDKDAQGGEVYLLSGPTMMMPGHGHGHMEHSNWRMINLPVGPLVDGKPIYTLYIALSIDFHLHYINDLMNKLIMTASVISILIVFIVLLAVHKGHAPIRSVSRQIQNITSKDLDVRLDPQTVPIELEQLVLSFNHMIERIEDVFTRQSNFSADIAHEIRTPITNLITQTEIALSQSRSQKELEDVLYSNLEELTRMAKMVSDMLFLAQADNNQLIPEKKMLNLADEVGKVFDFFEALAEDRGVELRFVGDECQVAGDPLMLRRALSNLLSNALRYTPTGETIVVRCQTVDHLVQVTVENPGTPIAPEHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSIVVAHKGTVAVTSDVRGTRFVIILPA
Member of the two-component regulatory system CusS/CusR involved in response to copper and silver. Acts as a copper/silver ion sensor. Activates CusR by phosphorylation.
Q8FK37
A4XHE0
SYE1_CALS8
Glutamyl-tRNA synthetase 1
Caldicellulosiruptor
MEVRTRFAPSPTGHLHIGGARTALFNYLFAKRYGGKFILRIEDTDLERSSIESEKVIIESLRWLGIEWDEGVEVGGPYGPYRSTERVDIYKKYVDVLFEKGYAYYCYCTEEELEAQRQELLSKGQMPRYLGKCRNLTEDQKRRFEQEGRKPTVRFKVPEGVKIVVHDLVRGDVEFLSDDIGDFVIVKSDGIPTYNFAVVIDDHLMKISHVIRGEEHLSNTPRQILIYNALGFELPQFAHVSLILGKDRTKMSKRHGSTWVEQYRDQGYLKEGLINFLALLGWSPPEDREIFDMEYLIENFSLERVSKNPAIFDIDKLNYINSQHIKLKSLDELTQMCIPYFVEAGYIKEDEAKSKFEWLKKIVKSVYEGLDYLSQIKDRVDIFFNNEVKIEEDEAKEVLKWDHVKDLINVFENKIRQMNELTPEAIKLLFKEIQKETGYKGKNLFMPIRVALTGKTHGPELVEIIEIVGKENILKRLEFFKTWYN
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
A4XHE0
Q97IQ4
CRCB1_CLOAB
Putative fluoride ion transporter CrcB 1
Clostridium
MKKYILIGLGGAIGAILRCFIRNTKIPVYKGEFPISTLMINLSGAFILAVILITANEIWSFNEEIRLGIATGFVGAYTTFSTMCKETIILMNKNLYFLAFCYVTVSVVFGLLFAYFGALSARKILSRLLKVRKEDEKAS
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
Q97IQ4
O31456
YBFP_BACSU
Uncharacterized HTH-type transcriptional regulator YbfP
Bacillus
MYYEKAVQKTINWIESHLHEQISNEDIVNVSSFSKFHFHRIFQKEVGMSVASYIRLRRLANAAAALLYTDHRIIDIALYYQFESQEAFTRTFKKMYHMPPGAYRTFMKRFTSKKEESYMEKKMKGWVLSGSHPFQFEMGIDRENVHQGKASGYLKSTMVQDIGEFATMMQQFKADRYLGKRLRLSSFIKTKGVQHFASLWMRVDSAADDVLQFDNMSNRPITGTTNWNHYAIVLDVPENSAVISFGVQLSGPGQVWMDHVVFEEVDESVPSTNLEMPGELLDEPVNLSFEEELQK
Probable transcriptional regulator.
O31456
A1U776
ZNUC_MARN8
Zinc import ATP-binding protein ZnuC
Marinobacter
MTDPLVRLEQITVAFDDRPVVDRVNLTVSRGDIVTIIGPNGAGKTTLIKTVLGIQRATSGQLSVAPGLVIGYVPQHLTLEPTLPLSVRRFMLLSGRTLADCTAALERTGVAHLLDASVHHLSGGEKQRLLLARALARKPDLLVLDEPAQGVDINGQATLYDLIRQLRDELHCGIIMISHDLHLVMAATDRVICLNQHVCCSGYPEDISQDPAFVETFGHQVAESLAVYHHHHNHRHNLHGDVVSSADAHEGCSHDHH
Part of the ABC transporter complex ZnuABC involved in zinc import. Responsible for energy coupling to the transport system.
A1U776
Q473U3
NUOA_CUPPJ
NUO1
Cupriavidus
MTLEAYFPVLIFIIFGVVLGIALMSIGRILGPNKPDPAKLSPYECGFEAFEDARMKFDVRYYLIAILFILFDLETAFLFPWGVALREIGWPGFIAMGVFLLEFIVGFVYIWKKGALDWE
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Q473U3
P43218
GIPR_MESAU
Glucose-dependent insulinotropic polypeptide receptor
Mesocricetus
MPLRPRLLLLCLWGLLLQQAETDSEGQTTGELYQRWERYARECEETLTAADPPSGMVCNGSFDMYVCWDYTAANTTAQASCPWYLPWYRHVAAGYVFRQCGSDGQWGPWRDHTQCENPEKNGAFQDQRLILERLQVVYTVGYSLSLGTLLLALLILSLFRRLHCTRNYIHMNVFLSFMLRAVAILTRDRLLPTLGPYPGDRTLTLRNQALAACRTAQIVTQYCVGANYTWLLVEGVYLHHLLVIVGGSEKGHFRCYLLLGWGAPALFVIPWVIVRYLLENTQCWERNEVKAIWWIIRTPILITILINFFIFIRILGILVSKLRTRQMRCPDYRLRLARSTLTLVPLLGVHEVVFAPVTEEQAEGTLRFAKLAFEIFLSSFQGFLVSVLYCFINKEVQSEIRRSWRHRVLHLSLRDERPCPHAELGPQALPSRSAPREVPITGSTLPSGPLHGPGEEVLESYC
This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
P43218
A6V4E2
NUOH_PSEA7
NDH-1 subunit H
Pseudomonas
MSWLTPALVTIILTVVKAIVVLLAVVICGALLSWVERRLLGLWQDRYGPNRVGPFGAFQLGADMIKMFFKEDWTPPFADKMIFTLAPVIAMGALLVAFAIVPITPTWGVADLNIGILFFFAMAGLTVYAVLFAGWSSNNKFALLGSLRASAQTISYEVFLALSLMGIVAQVGSFNMRDIVQYQIDNVWFIIPQFFGFCTFIIAGVAVTHRHPFDQPEAEQELADGYHIEYAGMKWGMFFVGEYIGIVLVSALLATLFFGGWHGPFLDTLPWLSFFYFAAKTGFFIMLFILIRASLPRPRYDQVMAFSWKVCLPLTLINLLVTGALVLAAAQ
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.
A6V4E2
B2VHX9
LPXB_ERWT9
Lipid-A-disaccharide synthase
Erwinia
MPKHPLTIALVAGETSGDILGAGLIRALKEKHPDARFVGVAGPLMQSEGCEAWYEMEELAVMGIVEVLGRLRRLLHIRRDLTRRFTALKPDVFVGIDAPDFNITLEGRLKQQGIRTIHYVSPSVWAWRQKRVFKIGRATDLVLAFLPFEKAFYDRFNVPCRFIGHTMADAMPIVPDKQAARRELGIAPQALCLALLPGSRSAEVEMLSADFLKTAMLLREKYPQLEIVVPLVNPRRRAQFEAIKAEVAADLPMHLLDGKGREAMLASDAALLASGTAALECMLAKCPMVVGYRMKPFTFWLAKRLVKTDYVSLPNLLAGRELVPELLQDECQPQRLAAALEPLLAQGETRDTLLATFAELHHQIRWNADEQAAAAVLELCR
Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
B2VHX9
Q3K076
TRHO_STRA1
tRNA hydroxylation protein O
Streptococcus
MSEKIRVLLYYKYVSIENAEEYAAKHLEFCKSIGLKGRILIADEGINGTVSGDYETTQKYMDWVHSDERFADLWFKIDEENQQAFRKMFVRYKKEIVHLGLEDNNFDSDINPLETTGEYLNPKQFKEALLDEDTVVLDTRNDYEYDLGHFRGAIRPDIRNFRELPQWVRDNKDKFMEKRVVVYCTGGVRCEKFSGWMVREGFKDVGQLHGGIATYGKDPEVQGELWDGAMYVFDDRISVPINHVNPTVISKDYFDGTPCERYVNCANPFCNKQIFASEENEAKYVRGCSPECRAHERNRYVQENGLSRQEWAERLEAIGESLPQVANV
Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.
Q3K076
Q723T1
IOLA_LISMF
Methylmalonate-semialdehyde dehydrogenase
Listeria
MADVRKLKNYINGEWVESRADKYEDVINPATGEVLCQVPISTRAELDQAAVIAEQAFEKWSQVAVPRRARVLFSFQQLLIQHKEKLARLITLENGKNLSEARGEVQRGIENVEFAAGAPTLMMGDSLASIATDVEAANYRYPVGVVGGIAPFNFPMMVPCWMFPMAIALGNSFILKPSERTPLLMEKLVELFSEAGLPKGVFNVVYGAHDVVNGILENEIIKAVSFVGSKPVGEYVYKTGSANLKRVQALTGAKNHTIVLNDADLEDTVTNVISAAFGSAGERCMACAVVTVEEGIADEFLAALRTAAQNVKIGNGLDDGVFLGPVIREENQKRTIAYIEKGLEEGAKLTVDGRETGLSEGHFVGPTILEDVTTDMTIWKDEIFAPVLSVIRVKNLQEAVRVANQSEFANGACIFTNNAKAIRYFREKIDAGMLGVNLGVPAPMAFFPFSGWKSSFYGTLHANGKDSVDFYTHKKVVTARYSLKGYEE
Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively.
Q723T1
Q1JJC0
RECF_STRPC
DNA replication and repair protein RecF
Streptococcus
MWIKELELKHYRNYDHLLASFSSGLNVFIGNNAQGKTNFLEAIYFLSLTRSHRTRADKELIHFDHSTVSLTGKIQRISGTVDLEINLSDKGRVTKINALKQAKLSDYIGTMMVVLFAPEDLQLVKGAPSLRRKFIDIDLGQIKPVYLSELSHYNHVLKQRNSYLKSAQQIDAAFLAVLDEQLASYGARVMEHRIDFINALEKEANTHHQAISNGLESLSLSYQSSVVFDKKTNIYQQFLYQLEKNHQKDFFRKNTSVGPHRDELAFYINGMNANFASQGQHRSLILSLKMAEVSLMKALTGDNPILLLDDVMSELDNTRQTKLLETVIKENVQTFITTTSLDHLSQLPEGIRIFHVTKGTVQIDSDIH
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.
Q1JJC0
B5XV26
CYSH_KLEP3
PAdoPS reductase
Klebsiella
MSVLDLNALNALPKVERILALAETNAKLEKLSAEERVAWALENLPGEYALSSSFGIQAAVSLHLVNQLRPDIPVILTDTGYLFPETYQFIDELTDKLKLNLKVYRAQESAAWQEARYGKLWEQGVEGIEKYNEINKVEPMNRALKELNTQTWFAGLRREQSGSRATLPVLAIQRGVFKVLPIIDWDNRTVYQYLQKHGLKYHPLWDQGYLSVGDTHTTRKWEPGMAEEETRFFGLKRECGLHEG
Catalyzes the formation of sulfite from phosphoadenosine 5'-phosphosulfate (PAPS) using thioredoxin as an electron donor.
B5XV26
A7ZXG5
ALLB_ECOHS
Allantoin-utilizing enzyme
Escherichia
MSFDLIIKNGTVILENEARVVDIAVKGGKIAAIGQDLGDAKEVMDASGLVVSPGMVDAHTHISEPGRSHWEGYETGTRAAAKGGITTMIEMPLNQLPATVDRASIELKFDAAKGKLTIDAAQLGGLVSYNIDRLHELDEVGVVGFKCFVATCGDRGIDNDFRDVNDWQFFKGAQKLGELGQPVLVHCENALICDALGEEAKSEGRVTAHDYVASRPVFTEVEAIRRVLYLAKVAGCRLHICHISSPEGVEEVTRARQEGQDVTCESCPHYFVLDTDQFEEIGTLAKCSPPIRDLENQKGMWEKLFNGEIDCLVSDHSPCPPEMKAGNIMEAWGGIAGLQNCMDVMFDEAVQKRGMSLPMFGKLMATNAADIFGLQQKGRIAPGKDAEFVFIQPNSSYVLTNDDLEYRHKVSPYVGRTIGARITKTILRGDVIYDIEQGFPVAPKGQFILKHQQ
Catalyzes the conversion of allantoin (5-ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring.
A7ZXG5
A1URK5
PURA_BARBK
IMP--aspartate ligase
Bartonella
MANVVVVGTQWGDEGKGKIVDWLSEQADVVVRYQGGHNAGHTLVINGISYKLSLLPSGVVRGKLSVIGNGVVVDPHHFVSELKKLRDQGVEITPKVLRVAENASLILSVHRDLDAARENGISGLTIGTTKRGIGPAYEDKVGRRSIRMIDLAETNTLMAKIERLLRHHNALRRGMGIAEIDPKTLYDELMQVADEILPFMDCTWRLLDERHRMGQRILFEGAQGASLDNDFGTYPYVTSSNTVSGQAFIGSGMGPGSVHYVLGIAKAYTTRVGEGPFPTEQVNDVGEFLGMRGNEFGVVTGRKRRCGWFDAVLVRQMVKICSVRGIALTKLDVLDGLDEIKICIGYEIDGRKIDYLPSCIEEQARVKPIYETLEGWKEATACTLNWEELPVQAIKYVRRIEELIGVPIALLSTSPEREDTIFIIDPFAD
Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.
A1URK5
A6TVF1
WHIA_ALKMQ
Probable cell division protein WhiA
Alkaliphilus
MSYSSNTKNELARIEGEQSCCVRAELAALIRMSGTLQLVGSQKLNIKVTTENPAIARRLFKIIKKQYNIHAEVMIRRNARLKKNNYYLLVITHSMGSSEVLADLGIMKKVDDSFDITYRIPQELTQNRCCKRAYLRGAFLGGGSVSDPEKTYHLEFVTHHKELSEGLRDLINSFDLNAKVVERKGNYVVYLKEGDQVVDLLNIVGAHSALLDLENIRVYKEMRNNVNRIVNCETANLSKTVDASIRQIQNIQYIEGSIGINRLPDNLREVAELRVEYQDATLKELGEMINPPIGKSGVNHRLRKLDQIADRERGKSI
Involved in cell division and chromosome segregation.
A6TVF1
Q9RC23
MRSD_BACSY
Mersacidin-modifying enzyme MrsD
Bacillus
MSISILKDKKLLIGICGSISSVGISSYLLYFKSFFKEIRVVMTKTAEDLIPAHTVSYFCDHVYSEHGENGKRHSHVEIGRWADIYCIIPATANILGQTANGVAMNLVATTVLAHPHNTIFFPNMNDLMWNKTVVSRNIEQLRKDGHIVIEPVEIMAFEIATGTRKPNRGLITPDKALLAIEKGFKERTKHPSLT
Catalyzes the oxidative decarboxylation of the C-terminal cysteine residue of mersacidin to an aminoenethiol residue.
Q9RC23
C7LYP4
ARC_ACIFD
Proteasomal ATPase
Acidimicrobium
MPRDETPEREHAEQQSRQALEEEVRELRRRVEEAPSRVRALEEKLLEVSGALAQTQAKNEKLTFTLQQAREHIQNLREEVEKLTQPPSAYGVYLAANQDGTADVFTTGRKMRVAVHPEIDLAAVRVGQEVVLNESFAIVSVRGSDVIGEVATVKDVLDDGSRVILLGRADEERVAQVAGHLQHPPLRVGDSVMVDPRSAMVLERLPRPEVSELALEEVPDITYHDIGGLDRQIEEIQDAVELPFLYRELFGDYRLPAPKGILLYGPPGCGKTLIAKAVANSLAKKVEQVSGRSVRSYFLNVKGPELLNKYVGETERQIRLIFQRAREKAEEGVPVIVFFDEMDSLFRTRGSGISSDMESTVVPQLLAEIDGVEALRNVIVIGASNREDLIDPAILRPGRLDVKIKIERPDEQAAREIFARYLTPEVPIDAGEVTTLGGGDAEKAIAVMIERTVERMYATSDENRFLEVTYQNGEKEILYFKDFSSGAMIENIVRRAKKLAIKREIAGGSRGICLDDLLASIAKEFKEHEDLPNTTNPDDWAKISGRKGERIVFMRILLHEEEGQTGGRAIERVATGQYL
ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis.
C7LYP4
Q2S1N5
RIMP_SALRD
Ribosome maturation factor RimP
Salinibacter
MNPTQQHLADRVSGLTEEVIVGTDYFLVDVEVRGHKGTRVVEVYIDSEEEVGHDDLALISKEIGFLLDVEDVVDGSYKLELSSPGIKRPLTMPAQYRKNVGRTLRVRFESDGDEEIVVGDLTDADDEEIELELPSAERLQLPYTTITQARIELPW
Required for maturation of 30S ribosomal subunits.
Q2S1N5
A7GGI2
GLYA_CLOBL
Serine hydroxymethyltransferase
Clostridium
MDFTNLKNTDPELLDMIKKEEERQEYNIELIASENFTSLSVMEAMGSLLTNKYAEGYPHKRYYGGCEFVDEVEDLARERLKKLFAAEHANVQPHSGSQANMAVYMSVLQTGDTILGMDLSHGGHLTHGSPVNFSGKLYNFISYGVDKETETIDYDQLKKIALENRPKMIVSGASAYPRIIDFEKIREICDEIDAYMMVDMAHIAGLVATGLHPSPVPYADFVTTTTHKTLRGPRGGAILCKEKYAKAVDKAIFPGIQGGPLMHTIAAKAVCFREALREDYKEYMQQVVKNTKVLGEELKNYGFRLISGGTDNHLLLIDLTNKNITGKDAEKLLDSVGITVNKNTIPFETLSPFITSGIRIGTPAVTTRGFKEEEMKKIAYFMNYSIEHREENLSQIKEQIKEICKKYPLYQNA
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
A7GGI2
Q3BWP3
RNH_XANC5
Ribonuclease H
Xanthomonas
MKFIEVHTDGSCLGNPGPGGWAALLRYNGREKELAGGEAVSTNNRMELMAAIMALETLTEPCQIVLHTDSQYVRQGITEWMPGWVRRNWKTAGGDPVKNRELWERLHAATQRHRIDWRWVKGHNGDPDNERVDVLARNQAIAQRDGLATS
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
Q3BWP3
Q8Z227
MALT_SALTI
ATP-dependent transcriptional activator MalT
Salmonella
MLIPSKLSRPVRLDHTVVRERLLAKLSGANNFRLLLVTSPAGYGKTTLVSQWAAGKNELGWYSLDEGDNQQERFASYLIAAIQQATGGHCSTSEAMAQKRQYASLTSLFAQLFIELAQWHRPLYLVIDDYHLITNPVIHDAMRFFLRHQPENFTLVVLSRNLPQLGIANLRVRDQLLEIGSQQLAFNHQEAKQFFDRRLSSPIEAAESSRMCDDVAGWATALQLIALSARQNHTSAHHSARRLAGINASHLSDYLVDEVLDNVDVSTRHFLLKSAILRSMNDALIVRVTGEENGQMRLEEIERQGLFLQRMDDTGEWFSYHPLFGSFLRQRCQWELAAELPEIHRAAAESWMEQGFPSEAIHHALAAGDAQMLRDILLNHAWGLFNHSELALLEESLKALPWESLLENPRLVLLQAWLMQSQHRYSEVNTLLARAEQEIKGVMDGTLHAEFNALRAQVAINDGNPEEAERLAKLALDELPLAWFYSRIVATSVHGEVLHCKGNLSQSLSLMQQTEQMARHHDVWHYALWSLIQQSEIQFAQGFLQAAWETQERAFQLIKEQHLEQLPMHEFLVRIRAQLLWAWARLDEAEASARSGIAVLSTFQPQQQLQCLTLLVQCSLARGDLDNARSQLNRLEKLLGNGRYHCDWISNADKVRVIYWQLTGDKKSAANWLRHTPKPAFANNHFLQGQWRNIARAQILLGEFEPAEIVLEELNENARSLRLMSDLNRNLLLLNQLYWQSGRKNDAQRVLLDALQLANRTGFISHFVIEGEAMAQQLRQLIQLNTLPEMEQHRAQRILRYINQHHRHKFAHFDEGFVERLLNHPDVPELIRTSPLTQREWQVLGLIYSGYSNEQIAGELAVAATTIKTHIRNLYQKLGVAHRQDAVQHAQQLLKMMGYGV
Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides. Specifically binds to the promoter region of its target genes, recognizing a short DNA motif called the MalT box.
Q8Z227
Q9GK68
GDF9_BOVIN
Growth/differentiation factor 9
Bos
MALPNKFFLWFCCFAWLCFPISLDSQPSRGEAQIVARTALESEAETWSLLKHLDGRHRPGLLSPLLNVLYDGHREPPRLQPDDRALSYMKRLYKAYATKEGTPKSNRSHLYNTVRLFTPCAQHKQAPGDQAAGTLPSVDLLFNLDRVTVVEHLFKSVLLYTFNNSISFPFPVKCICNLVIKEPEFSSKTLPRAPYSFTFNSQFEFRKKYKWIEIDVTAPLEPLVASHKRNIHMSVNFTCVKDQLQHPSARDSLFNMTLLLAPSLLLYLNDTSAQAFHRWHSLHPKRKPSQDPDQKRGLSACPMGEEAAEGVRLSRHRRDQESVSSELKKPLVPASFNLSEYFKQFLFPQNECELHDFRLSFSQLKWDNWIVAPHKYNPRYCKGDCPRAVGHRYGSPVHTMVMNIIHEKLDSSVPRPSCVPAKYSPLSVLAIEPDGSIAYKEYEDMIATKCTCR
Required for ovarian folliculogenesis.
Q9GK68
Q30ZH4
ISPE_OLEA2
4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase
Oleidesulfovibrio
MLTVPQQTIRSGCKINLFLEITGVRPDGYHELVTLFYPLSEPFDLMEISPATHGVTVLSERADLCGDKNIICKAWHTFAAAGGTPPPMQVRLAKGVPDGAGLGGGSANAAAVLKLLNTAGGAPRFSDTALAKIAAQVGADVPFFLHNTPCLATGIGEKLVPAPLDLSGWHLVLVCPGVQVSTPWAYNRWDTLYRSGLHHPCGQLPAAHAPAACAQLQTTGPDRPVRAETGCAGRKKNTCRSLTTERQADSKPVSRALWLFNSFETVVFSAYSELRQHKNTLLAHGASAALMSGSGSSLFGLFRDKAQAEAAMLHFCQRSIAVYVHRL
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
Q30ZH4
A6UVA8
ASPD_META3
L-aspartate dehydrogenase
Methanococcus
MLKIGIIGCGTIATMIAKAINYKKINGTIVALYDKHNDKSQDLNKLTNAKICDSIDKLVKEELDIVIECASIKSVEEVATKSLNHKKNVVIMSVGALADKNLFSKLYKIANDNEKKIFVPSGAIAGVDAIKTASIGRIDEVSLITTKPVYGLEDALKNKGIDTTNISEPTVVFEGTVFDAIKEFPQNINVSVVLSIASKIPAKVKIVADPSATSNKHEIIVKGSIGTIKTVVENNPCKDNPKTSALAAYSVIRLLKDLSEPIIVGT
Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.
A6UVA8
Q5R6T1
PDIA6_PONAB
Protein disulfide-isomerase A6
Pongo
MALLVLGLVSCAFFLEVNGLYSSSDDVIELTPSNFNREVIQSDSLWLVEFYAPWCGHCQRLTPEWKKAATALKDVVKVGAVDADKHHSLGGQYGVQGFPTIKIFGSNKNRPEDYQGGRTGEAIVDAALSALRQLVKDRLGGQSGGYSSGKQGRSDSSSKKDVIELTDDSFDKNVLDSEDVWMVEFYAPWCGHCKNLEPEWAAAASEVKEQTKGKVKLAAVDATVNQVLASRYGIRGFPTIKIFQKGESPVDYDGGRTRSDIVSRALDLFSDNAPPPELLEIISEDIAKRTCEEHQLCVVSVLPHILDTGAAGRNSYLEVLLKLADKYKKKMWGWLWTEAGAQSELETALGIGGFGYPAMAAINARKMKFALLKGSFSEQGINEFLRELSFGRGSTAPVGGGAFPTIVEREPWDGRDGELPVEDDIDLSDVELDDLGKDEL
May function as a chaperone that inhibits aggregation of misfolded proteins. Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling. May also regulate the UPR via the EIF2AK3 UPR sensor. Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin.
Q5R6T1
Q8W3L1
MFDR_ARATH
Mitochondrial ferredoxin reductase
Arabidopsis
MSRYLARYMVSRYFSSASSRPLHVCIVGSGPAGFYTADKVLKAHEGAHVDIIDRLPTPFGLVRSGVAPDHPETKIAINQFSRVAQHERCSFIGNVKLGSDLSLSELRDLYHVVVLAYGAESDKDLGIPGESLSGIYSAREFVWWYNGHPDYSSLKPDLKTSDSAVILGQGNVALDVARILLRPTTELASTDIATHALSALKESSIRKVYLIGRRGPVQAALTAKELREVLGIKNLHIRIKQTDLSVTPADEEEMKTSRARKRIYELLSKAAAAAKTSEADPDQRELHFVFFRQPDQFLESDERKGHVSGVNLQKTILESVGTGKQIAVGTGEFEDLNCSMVLKAIGYKSVPVNGLPFDHKKGVVPNVKGRVVSHTSGDISQTEPGLYVCGWLKRGPVGIIATNLYCAEETVGSISEDIEEGVWKSSKAGSKGLMQLLEKRKVKKVEFSGWEKIDAKEKQMGIERNKPREKLVTWEDLLAAAAN
Associates in vitro with the adrenodoxin-like protein MFDX1 to form an efficient low potential electron transfer chain that is able to reduce cytochrome C . Functions as accessory mitochondrial protein involved with BIO2 in the plant biotin synthase reaction .
Q8W3L1
Q7Z0Q2
RNKB_CERCA
Cc RNase
Ceratitis
MKICGPKLSLCGLIISVWGIIQLVLMGLFFYINSVALIEDLPIDEEFNSVEEFYTAATSAYNQNAYNCWIAACIYVLTLLLSAQQFYVNSRATAN
Endoribonuclease which displays activity against poly(C) and poly(U) synthetic substrates, as well as rRNA.
Q7Z0Q2
Q8KAN7
RNC_CHLTE
Ribonuclease III
Chlorobaculum
MSLQFLRSEASDGAGETSDASSADFLLDPQTATHLARLTGRPCNRLIYRTALTHRSVLHDHHSEEHKPESNQRLEFLGDAVLDLLISEHLFKQFPGSDEGHLSSNRAKIVNRKSLAAFALELQLGEHLIIGESADKQKIRTSESALADALEALVGAIYLDQGLAGAERFITNHVIAKVDLHKLVEAEYNYKSRLIEYTQSRQLPPPLYTVITEEGAEHEKTFVVEVSCNGQPLGRGTAPRKKDAEQLAAKEAMKRLESGDLGNLNEPSPQNS
Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
Q8KAN7
P66901
DPAL_ECO57
Alpha,beta-diaminopropionate ammonia-lyase
Escherichia
MSVFSLKIDIADNKFFNGETSPLFSQSQAKLARQFHQKIAGYRPTPLCALDDLANLFGVKKILVKDESKRFGLNAFKMLGGAYAIAQLLCEKYHLDIETLSFEHLKNAIGEKMTFATTTDGNHGRGVAWAAQQLGQNAVIYMPKGSAQERVDAILNLGAECIVTDMNYDDTVRLTMQHAQQHGWEVVQDTAWEGYTKIPTWIMQGYATLADEAVEQMREMGVTPTHVLLQAGVGAMAGGVLGYLVDVYSPQNLHSIIVEPDKADCIYRSGVKGDIVNVGGDMATIMAGLACGEPNPLGWEILRNCATQFISCQDSVAALGMRVLGNPYGNDPRIISGESGAVGLGVLAAVHYHPQRQSLMEKLALNKDAVVLVISTEGDTDVKHYREVVWEGKHAVAP
Catalyzes the alpha,beta-elimination reaction of both L- and D-alpha,beta-diaminopropionate (DAP) to form pyruvate and ammonia. The D-isomer of serine is degraded to pyruvate, though very poorly; other amino acids (L-serine, D- and L-threonine, D- and L-beta-Cl-alanine) are not substrates.
P66901
Q21DK5
ATPD_SACD2
F-type ATPase subunit delta
Saccharophagus
MAEFTTLARPYAKAAFIAARDASDLGGWSKALATAAAVSQVDRVKTVLSAPGLTAQQKADAFVALCGEELAEKQQNFIHVLADNRRLALLPEISVLFDLYKANQEKSLDVTVETAFEIDAATEKKLVEALSKKLDREVTLSTAVDKALLGGALIRAGDTVIDGSVRGRLAKLAEAMNV
This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
Q21DK5
Q9SU36
ORP2B_ARATH
OSBP-related protein 2B
Arabidopsis
MPLTRSKSLPATENGGSDRETLQSGRSVAGILYKWTNYGKGWRSRWFLLRDGILSYSKIRRPENVNLLSPSDDLRLIGDISTDRLLRMKSCSGRSRRKHHKNIGIVHLKVSSYRESKSDHRKFYIFTATKTLHLRTDSRSDRAAWLQALASTRGIVPLQSINGDFSFVSPKDLSISTERLKKRLFEEGMNESLVKECEQIVDSEFCEVQEQIKLLHEERKKLLDALRQLEMANLEAEASGIHDDVYQLRNHKYSSLGRGKYSECSTSASSDDKQEFEDISEEDEASFHDTKESFGEPDVGSVLTHFKRRTKLPDPAEKERGVSLWSMIKDNVGKDLTRVCLPVYFNEPISSLQKCFEDLEYSYLLDQAYEYGKSGKSLLRALNVAAFAVSGYASTEGRHCKPFNPLLGETYEADFPEKGIRFFSEKVSHHPTVIACHCEGKGWKFWGDTNLRSKFWGRSIQLEPVGILTLEFDDGEIFQWSKVTTTIYNILLGKLYCDHHGIMKIRGNRQYSCMLKFKEQSILDRNPHQVNGFVEDVTGKKAATVFGKWNDSLYYVAGDGINKASASLLWKATKAPPNVTRYNFTSFAMTLNELIPGLEEKLPPTDSRLRPDQRHLENGEYEKANEEKQRLERRQRMSRQIQESGWRPRWFEPQGESESYKYTGGYWEARDVKSWDDCPNIFGEFTEEVADCA
May be involved in the transport of sterols.
Q9SU36
A0AEN2
PURA_LISW6
IMP--aspartate ligase
Listeria
MSSVVVVGTQWGDEGKGKITDFLSENAEAIARYQGGNNAGHTIKFDGETYKLHLIPSGIFYKEKISVIGNGMVVDPKALVEELKYLHDKGVDTSNLRISNRAHIILPYHIRIDEADEERKGANKIGTTKKGIGPAYMDKAARVGIRIIDLLDKETFKEKLEHNLGEKNRLLERFYELEGFKLEDILEEYYGYGQQFKDYVCDTSVVLNDALDDGKRVLFEGAQGVMLDIDQGTYPFVTSSNPIAGGVTIGSGVGPSKINHVVGVAKAYTTRVGDGPFPTELFDSIGDNIREVGREYGTTTGRPRRVGWFDSVVVRHARRVSGLTDLSLTLLDVLTGIETLKICVAYKLDGKTITEFPASLKDLARCEPVYEELPGWTEDITEVKSLDDLPVNCRHYMERIAQLTGVQVSMFSVGPDRAQTHVVKSVWRLA
Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.
A0AEN2
Q5N5U2
CHLN_SYNP6
Light-independent protochlorophyllide reductase subunit N
Synechococcus
MTTTEAPSALSFECETGNYHTFCPISCVAWLYQKIEDSFFLVIGTKTCGYFLQNAMGVMIFAEPRYAMAELEEGDISAQLNDFAELKRLCTQIKRDRNPSVIVWIGTCTTEIIKMDLEGLAPKLEAEIGIPIVVARANGLDYAFTQGEDTVLAAMPARCPEAATSEADQQERTNAIQRLLQFGKSPAAEQQPASSKHPPLILFGSVPDPVATQLTIELAKQGITVSGWLPAKRYTELPVIAEGSYAIGLNPFLSRTATTLMRRRKCKVIGAPFPIGPDGSRAWIEKICSVLEIEPQGLAEREAQVWDSIEDYRQLVEGKQVFFMGDNLWEISLARFLVRCGMRCPEIGIPYLDRRYLGAELAMLEATCQSMGVPLPRLVEKPDNYNQLQRIEALQPDLVITGMAHANPLEARGISTKWSVEFTFAQIHGFGNARAILELVTRPLRRNLALGTLGGSQWVSEAVTSR
Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein (ChlN-ChlB) is the catalytic component of the complex.
Q5N5U2
P49371
HUGA_DOLMA
Hyaluronoglucosaminidase
Dolichovespula
SERPKRVFNIYWNVPTFMCHQYGLYFDEVTNFNIKHNSKDDFQGDKISIFYDPGEFPALLPLKEGNYKIRNGGVPQEGNITIHLQRFIENLDKTYPNRNFNGIGVIDFERWRPIFRQNWGNMMIHKKFSIDLVRNEHPFWDKKMIELEASKRFEKYARLFMEETLKLAKKTRKQADWGYYGYPYCFNMSPNNLVPDCDATAMLENDKMSWLFNNQNVLLPSVYIRHELTPDQRVGLVQGRVKEAVRISNNLKHSPKVLSYWWYVYQDDTNTFLTETDVKKTFQEIAINGGDGIIIWGSSSDVNSLSKCKRLREYLLTVLGPITVNVTETVN
Hydrolyzes high molecular weight hyaluronic acid to produce small oligosaccharides.
P49371
Q219F8
PTH_RHOPB
Peptidyl-tRNA hydrolase
Rhodopseudomonas
MRLLVGLGNPGAKYQGNRHNIGFMVLDEMARRHGFSPWRRRFQGETADGSIGGERVTLLKPLTYMNDSGRAVQDAASFFKLGLPDITVVHDEIELPAAKLRVKVGGGIAGHNGLRSISAHVGNDYRRVRIGVGHPGAKELVHGHVLNDFAKSERPWVEAMIEAIVEHAGLLVDGRDSTFQNKVHLALQAKGFLDNNDGSAA
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
Q219F8
Q38XW7
PURL_LATSS
Phosphoribosylformylglycinamidine synthase subunit II
Latilactobacillus
MVNNPTAIEIQQTKLYQQWGLTDSEYELICTKILKRLPNYTETGLFSVMWSEHCSYKNSKPILKKFPTNGPHVLQGPGEGAGILDIGDGQAVVFKAESHNHPSAVEPYEGAATGVGGIIRDIFSMGATPIAILDSLRFGELNDNQTKYLVQEVVAGIGGYGNCIGIPTVGGEISFDPCYQANPLVNAMCVGLIEQKDIQQGKARGAGNSVLYVGAKTGRDGIHGATFASDEFAEGKATQRSAVQVGDPFMEKLLMDACLELILQHSDWLVGIQDMGAAGLVSSTAEMAAKAGTGMILDLDQVPQRETDMSAYEIMLSESQERMALCVRAGYEDQVIALFKGYDLDAVRIGEVTTKEQYQLWHQGQLVADLPVAALTDAAPVYHKDQAKPERLATFAAQAPYVPSVTDTQATWLALLKQPTIADKSSFYRHYDAQVKTNTVVLPGSDAAVVRIRGTKKALAMTTDCNGRYLYLDPHVGGQIAVAEAARNIVAAGGQPLGITDCLNYGNPEKPAVFWEFDQSAQGIAAACETFGTPVISGNVSLYNEFNGEAIYPTPMIGMVGLIRDIQDITTQDFKQVDDLIYLIGETDDNYAGSELQKMQQGTISDQLGHFSLATEKANQDLVLKAIQQGLITSAHDLSEGGLAVALSEATFKQGLGYHVQVDLASRQLFAETQSRFIVTVKAANQAAFEQISDQSAQLIGRVTAEPIMHIQTKDEMIDLTVEAAKDAWEAALPCLMKSEA
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
Q38XW7
B1WUD1
RIMO_CROS5
Ribosome maturation factor RimO
Crocosphaera subtropica
MGNKPTISVSHLGCEKNRIDSEHMLGILAQQGYSIDANEELADYVIVNTCSFIQEAREESVRTLVELAEANKKIIISGCMAQHFQEQLLEELPEAVALVGTGDYQKIAEVIQRVETGERVTEVSQNPTFVADEMTPRYRTTNEAVAYLRVAEGCDYRCAFCIIPHLRGNQRSRSIESIVTEAQQLADQGVQEIILISQITTNYGLDLYGEPKLAELLRALGKVDIPWIRIHYAYPTGLTPKVIDAIRDTPNILPYLDLPLQHSHPAILKAMNRPWQGQVNDNIIERLKQSIPNAILRTTFIVGFPGETEEHFEHLINFVQRHEFDHVGVFTFSPEEETPAYQMPNQVPSEIAQARRNYLMEIQQPIAAKKNQKCVGQTVEVLIEQENPTTQEYIGRSIRFAPEVDGVVYVEGEGQLNSIIPVKITDADVYDLYGKVI
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
B1WUD1
Q5YZ84
GLNE_NOCFA
Adenylyl transferase
Nocardia
MVRPPSARSAVPGVGRLGLLDPTAAASLRELGWDNVESIPVLWALSRAPDADLALNTLMRLREALGSDWQRLDSAIRTDTSLRGRLFALLGSSTALGDHLVAEPAAWEVLRRGDLPDRDELLADLLAAVQATPEAGPHAGPMLFRAGIAGPEAVALLRCRYRDQLMLLAALDLAATVENEPVLPYRVVGRHLTDLADAALTAALAVAVARVCKDQPCPVRLAVIAMGKCGARELNYVSDVDVVFVAEPADATATRLAAEMMSVGSQAFFEVDAALRPEGKQGALVRTLDSHLTYYKRWARTWEFQALLKNRPMTGDLELGREYRDAVMPMVWTASERPDFVPEVQGMRRRVEDLVPAELRERELKLGRGSLRDVEFAVQLLQLVHGRVDENLHVASTVDALSALAAGGYVGRDDAANLTASYEFLRLLEHRLQLQRLKRTHTLPADDDEEGMRWLARAAHIRPDGRQDAMGVLRSEIRRNAVRVRRLHAKLFYRPLLEAVVRMDPDALRLSPDAAVRQLAALGYAAPENAFGHLKALTGGVSRKGRIQALLLPTLLEWLGETPNPDAGLLAYRRVSEALDEQTWFLRELRDEGAVAQRLMIVLGSSEFLPDLLINAPETIRMFADGPHGPLLLGPQPEEVARGILTAAARYDDPNRAVAAARSLRRHELARVASADLLGMLEVPQVCRALSSVWVAVLDAALAAVIRAGEAESGEPAPAAFAVIGMGRLGGMELGYGSDADVLFVCEPRPGVDETKAVKWANTVAERVQRLLGAPSTDPPLHVDAGLRPEGRSGALVRTLSAYQAYYGQWAQSWEVQALLRAHQVAGDQELGVRFLHAVDKVRYPAGGVSEDAVREIRRIKARVDSERLPRGADPATHTKLGRGGLADIEWTVQLLQLRHAHEVESLHNTATLETLAAIEKAELLAAEDVALLRDSWLLATKARNALVLVRGKPSDQLPGPGRLLSAVATVAGWPNNDGGSEFLDHYLRITRRARAVVERVFGS
Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.
Q5YZ84
A1BD24
RPOC_CHLPD
Transcriptase subunit beta'
Chlorobium
MIFSQGASPLKGDFSKIKFSIASPESILAHSRGEVLKPETINYRTFKPERDGLMCEKIFGPTKDWECYCGKYKRVRYKGIICDRCGVEVTTKSVRRERMGHISLAVPVVHTWFFRSVPSKIGALLDLSTKELERIIYYEVYVVINPGEPGAKQGIKKLDRLTEEQYFQIITEYEDNQDLDDHDSDKFVAKMGGEAIRLLLKSIDLNETAIHLRKVLKESSSEQKRADALKRLKVVEAFRKSYEPQKKTRKKAVGLFPEDELPEPYVFEGNKPEYMVMEVVPVIPPELRPLVPLEGGRFATSDLNDLYRRVIIRNNRLKKLIDIRAPEVILRNEKRMLQEAVDALFDNSRKANAVKTGESNRPLKSLSDALKGKQGRFRQNLLGKRVDYSGRSVIVVGPELKLHECGLPKSMAIELFQPFVIRRLVERGIAKSVKSAKKLIDKKDQVVWDVLEKVIDGRPVLLNRAPTLHRLGIQAFQPVLIEGKAIQIHPLVCTAFNADFDGDQMAVHVPLSQEAQLEAALLMLSSHNLILPQSGKPVTVPSQDMVLGMYYLTKSRPGDPGEGRIFYSDEDVLIAYNEDRIGLHAQIFVHFNGAVDQKFDPLRVLDTIVDPKSEKYTWLKSQLEKKTILLTTVGRVIFNQNVPDSIGFINRVIDKKVAKELIGRLSSDVGNVETAKFLDNIKEVGFHYAMKGGLSVGLSDAIVPDTKVRHIKNAQKDSTKVVKEYNRGTLTDNERYNQIVDVWQKTSNIVAEESYQKLKKDREGFNPLYMMLDSGARGSREQVRQLTGMRGLIARPQKSMSGQPGEIIENPIISNLKEGLTVLEYFISTHGARKGLSDTSLKTADAGYLTRRLHDVAQDVIVTIEDCGTTRGLHVYRNIEEETSGQIKFREKIRGRVAARDIYDTLNNNVIVKAGEIITEELGDLIQETAGVEEAEIRSVLTCESKIGICSKCYGTNLSVHQIVEIGEAVGVIAAQSIGEPGTQLTLRTFHQGGTAQGGISETETKAFYEGQLEFEDLKTVEHSAITEDGVEEIRIIVVQKNGKINIVDPDSGKILKRYVVPHGAHLHCNAKALVKKDQVLFSSEPNSTQIIAELHGRVKFADIEKGVTYKEEVDPQTGFAQHTIINWRSKLRANETREPRVLIIDESGEVRKNYPVPIKSNLYVEDGQKIVPGDIIAKVPRNLDRAGGDITAGLPKVTELFEARIPSDPAIVSEIDGYVSFGSQRRSSKEIKVKNDFGEEKVYYVQVGKHVLANEGDEVKAGDAMTDGAVSPQDILRIQGPNAVQQYLVNEIQKVYQINAGVEINDKHLEVIVRQMLQKVRVEEPGDTELLPGDLIDRSAFVEANNNVAEKVRVTEKGDAPSRIQEGQLYKTRDITKLNRELRKNSKNLVAFEPALQATSHPVLLGITSAALQTESVISAASFQETTKVLTDAAVAGKIDYLAGLKENVIVGKLIPAGTGLKRYRNLTLTGESVETISHDASDDASTQNGI
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
A1BD24
Q3KHC5
DAPE_PSEPF
N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase
Pseudomonas
MTAHADLSPTLQLAIDLIRRPSVTPVDADCQKQMMQRLGDAGFQLEPMRIEDVDNFWATHGKGDGPVLCFAGHTDVVPTGPVTAWQIDPFNAVIDEHGMLCGRGAADMKGSLASMTVAAERFVADYPDHKGKVAFLITSDEEGPAHHGTKAVVERLAARNERLDWCIVGEPSSTTLVGDVVKNGRRGSLGAKLTVRGVQGHVAYPHLAKNPIHLAAPALAELAAEHWDHGNDFFPPTSFQISNVNSGTGATNVIPGDLVAVFNFRFSTESTVEGLQKRVADILDKHGLDWHIDWALSGLPFLTEPGALLDAVSSSIKDITGRETKASTSGGTSDGRFIATMGTQVVELGPVNATIHQVNERVLAADLDVLTEIYYQTLIKLLA
Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
Q3KHC5
Q8AXF4
FBX43_XENLA
Xerp1
Xenopus
MANLLENFAAHHSMTAGAKKKADHQDTSVSQDSGYSDSLKGFSPDSHKSGNFLETVTEGYENSENIDPTLILSPIKYELSWGADTRESKQLAPLYETPRVGKKEFSLRRRLLISKATSGGNLDFDVSVCSAESCGREKSLRRIPSHEGSLSNSFADSPRDGSYEPIATSTLKTESESGTSCKKWRLSFAQQRSSTLDDSKSDSIPLPEVENISPVQHSLASSTDDSILYEETIFGAPTTPTCNFIVKEEFQTPISNLAANFRFNLCTPDVGHVSDFDISVTEDSAFHSLSLDKSQDSITDHEGSFQELIQKPRETSKAVNNKSRLRKLDRCRRLSTLRERGSQSEVEEEGNEVPVLSSAYKLKVARASVDEENEFSSDESRVHSLLSSDDLTGKPALRVLHEMLLRSTRKRPQQATVQDLLGSSGCFELPEDSLSRLIGRKMGLETFDILAELKNRNLKHILASILDLVNAASICSMCRVSRDWRDVVLQDKSAHQRRKAYIKKLKTEAEQGRQLSFEDSATRLNILSRSALRSVQIQARSAFRTPTSSLTPGDNKSIHSASKHQEYLKVAKTLFTDEALKPCPRCQYPAKYQALKKRGTCSRKDCGFDFCSLCLCTFHGSKECGTGSAKRIPKKEALPGSAQSKRNLKRL
Required to prevent anaphase onset in cytostatic factor-arrested oocytes. Inhibits the anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase and prevents cyclin degradation. Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.
Q8AXF4
B3GXZ4
LEXA_ACTP7
LexA repressor
Actinobacillus
MSRKHLTARQQEIFDFVKHHIETTGMPPTRVEIAREIGFKSPNAAEEHLKALARKGYIEMLSGTSRGIRILVDNEETAANDDGLPLIGKVAAGTPIMAIEHVESHYPVNGAMFNPNADYLLKVNGNSMEKIGILDGDLLAVHKTNFARNGQVVVARVDDEVTVKRLEKKGDLIYLHPENDELQPIVVDPRIEYIEIEGIAVGVIRNNAWM
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
B3GXZ4
O88516
DLL3_MOUSE
Drosophila Delta homolog 3
Mus
MVSLQVSPLSQTLILAFLLPQALPAGVFELQIHSFGPGPGLGTPRSPCNARGPCRLFFRVCLKPGVSQEATESLCALGAALSTSVPVYTEHPGESAAALPLPDGLVRVPFRDAWPGTFSLVIETWREQLGEHAGGPAWNLLARVVGRRRLAAGGPWARDVQRTGTWELHFSYRARCEPPAVGAACARLCRSRSAPSRCGPGLRPCTPFPDECEAPSVCRPGCSPEHGYCEEPDECRCLEGWTGPLCTVPVSTSSCLNSRVPGPASTGCLLPGPGPCDGNPCANGGSCSETSGSFECACPRGFYGLRCEVSGVTCADGPCFNGGLCVGGEDPDSAYVCHCPPGFQGSNCEKRVDRCSLQPCQNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGRACANGGTCVEGGGSRRCSCALGFGGRDCRERADPCASRPCAHGGRCYAHFSGLVCACAPGYMGVRCEFAVRPDGADAVPAAPRGLRQADPQRFLLPPALGLLVAAGLAGAALLVIHVRRRGPGQDTGTRLLSGTREPSVHTLPDALNNLRLQDGAGDGPSSSADWNHPEDGDSRSIYVIPAPSIYAREDWLIQVLF
Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm.
O88516
A1R6G5
UVRC_PAEAT
Excinuclease ABC subunit C
Paenarthrobacter
MADPASYRPQTGEIPTTPGVYRFRDPHGRVIYVGKAKNLRSRLNSYFANPAGLLPKTHAMVHAASSVEWTVVGSELESLQLEYTWIKEFKPRFNVVFRDDKTYPYLAVTMGEKYPRVQVMRGERRKGTRYFGPYTAGAIRETMDTLLRVFPVRSCSAGVFKRAESSGRPCLLGYIDKCSAPCVGRVTPDEHRGLAEDFCSFMGGEAKRFISRLEKDMAAAVAELDYERAAGLRDDIIALRKVFERNAVVLAEDTDADVFALHEDELEASVQVFHVRGGRVRGQRGWVVEKVEDATTPELIEHLLQQVYGEDSEVQGRIPREVLVPENPSNHAELMEWLGGLRGARVDIRVPQRGDKAALMSTVRENAEQALKLHKTRRAGDITVRSLALQELQEALEIPVPLLRIECFDISHVQGTNVVASMVVVEDGLPKKSDYRKFSITGAAATDDTAAMHDVLTRRFRHYLTDKAAQVPIVSGEIVNPTRAGAKSGTELPPSDLDVPAPKAKFAYPPNLVVVDGGQPQVNAAARALAELGIDDVYVVGLAKRLEEVWLPDSDFPVILPRTSQGLYLLQRIRDEAHRFAITFHRQKRGKAMTVSVLDGVPGLGEAKRKALVAHFGSLKKIKAASVEELTSAKGIGPALAAAVVQHLGSTEDAGERAPAVNMTTGEILES
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
A1R6G5
Q01323
OTC_NEIFL
Ornithine carbamoyltransferase
Neisseria
KTSTRTRCAFEVAARDQGAGVTYLEPSASQIGHKESIKDTARVLGRMFDGIEYRGFGQDVVEELAKYAGVPVFNGLTNEFHPTQMLADGLTMREHSDKPLNQIAFAYVGDARYNMANSLLVLAAKLGMDVRISAPKSLWPSENIIEMVQAVAKETGGRILLTENVQEAVKGVDFIHTDVWVSMGEPKEAWQERIDLLKDYRVTPELMAAAENPQVKFMHCLPAFHNRETKVGEWIYETFGLNGVEVTEEVFESEASIVFDQA
Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.
Q01323
Q6D7I3
KDPA_PECAS
Potassium-translocating ATPase A chain
Pectobacterium
MAADAFLLIFGLLLTVLIVAQPLGSGLARLIEGETGTLLQKFETKTARFFALDTTEMRWQQYAAAILALNLIGIVVLFVLLMAQGNLPLNPENMPGLSWHLALNTAVSFVTNTNWQAYSGENTLSYLSQMVGLTVQNFLSAASGIAVAFALIRAFSRRCVDTLGNAWLDLLRITLYVLLPLSLLLALFFVSQGVLQNLLPYQHLTTLDGAAQTLPMGPVASQEAIKLLGTNGGGFFGANSAHPFENPTALSNIVQMLAILLIPTALCFAFGKAVSDKRQGHALLWAMALIFIVAAAVVMKMEVTGNPHLLALGADSAANLEGKETRFGVLTSSLYAVVTTATSTGAVNAMHDSFTALGGMVPLWLMQIGEVVFGGVGSGLYGMLLFVLLTVFIAGLMIGRSPEYLGKKIEVYEMKMTALAILIPPALVLLGTALALSTEAGRGGILNPGAHGFSEVLYAVSSAANNNGSAFAGLSVNTPFYNVLLAVAMLLGRFAVMVPVLAIAGSLVVKKRQPESKGSLSTRSPLFIGMLIAIVLLIGALTFIPALALGPVAEHLQFGLTH
Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds the periplasmic potassium ions and delivers the ions to the membrane domain of KdpB through an intramembrane tunnel.
Q6D7I3
Q32JQ8
METN_SHIDS
Methionine import ATP-binding protein MetN
Shigella
MIKLSNITKVFHQGTRTIQALNNVSLHVPAGQIYGVIGASGAGKSTLIRCVNLLERPTEGSVLVDGQELTTLSESELTKARRQIGMIFQHFNLLSSRTVFGNVALPLELDNTPKDEIKRRVTELLSMVGLGDKHDSYPSNLSGGQKQRVAIARALASNPKVLLCDEATSALDPATTRSILELLKDINRRLGLTILLITHEMDVVKRICDCVAVISNGELIEQDTVSEVFSHPKTPLAQKFIQSTLHLDIPEDYQERLQAEPFTDCVPMLRLEFTGQSVDAPLLSETARRFNVNNNIISAQMDYAGGVKFGIMLTEMHGTQQDTQAAIAWLQEHHVKVEVLGYV
Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system.
Q32JQ8
Q8RXS5
DRL40_ARATH
pNd11
Arabidopsis
MGGCVSVSISCDQLTKNVCSCLNRNGDYIHGLEENLTALQRALEQIEQRREDLLRKILSEERRGLQRLSVVQGWVSKVEAIVPRVNELVRMRSVQVQRLCLCGFCSKNLVSSYRYGKRVMKMIEEVEVLRYQGDFAVVAERVDAARVEERPTRPMVAMDPMLESAWNRLMEDEIGILGLHGMGGVGKTTLLSHINNRFSRVGGEFDIVIWIVVSKELQIQRIQDEIWEKLRSDNEKWKQKTEDIKASNIYNVLKHKRFVLLLDDIWSKVDLTEVGVPFPSRENGCKIVFTTRLKEICGRMGVDSDMEVRCLAPDDAWDLFTKKVGEITLGSHPEIPTVARTVAKKCRGLPLALNVIGETMAYKRTVQEWRSAIDVLTSSAAEFSGMEDEILPILKYSYDNLKSEQLKLCFQYCALFPEDHNIEKNDLVDYWIGEGFIDRNKGKAENQGYEIIGILVRSCLLMEENQETVKMHDVVREMALWIASDFGKQKENFIVQAGLQSRNIPEIEKWKVARRVSLMFNNIESIRDAPESPQLITLLLRKNFLGHISSSFFRLMPMLVVLDLSMNRDLRHLPNEISECVSLQYLSLSRTRIRIWPAGLVELRKLLYLNLEYTRMVESICGISGLTSLKVLRLFVSGFPEDPCVLNELQLLENLQTLTITLGLASILEQFLSNQRLASCTRALRIENLNPQSSVISFVATMDSLQELHFADSDIWEIKVKRNETVLPLHIPTTTTFFPNLSQVSLEFCTRLRDLTWLIFAPNLTVLRVISASDLKEVINKEKAEQQNLIPFQELKELRLENVQMLKHIHRGPLPFPCLQKILVNGCSELRKLPLNFTSVPRGDLVIEAHKKWIEILEWEDEATKARFLPTLKAFPENIDADGYEISF
Probable disease resistance protein.
Q8RXS5
B7GFR5
CH10_ANOFW
Chaperonin-10
Anoxybacillus
MLKPLGDRIVIELIQTEEKTASGIVLPDTAKEKPQEGKVVAVGSGRVLDNGERVAPEVSVGDRIIFSKYAGTEVKYDGKEYLILRESDILAVIG
Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
B7GFR5
Q8VWH2
RFT1_ORYSJ
FLOWERING LOCUS T-like protein 3
Oryza sativa
MAGSGRDDPLVVGRIVGDVLDPFVRITNLSVSYGARIVSNGCELKPSMVTQQPRVVVGGNDMRTFYTLVMVDPDAPSPSNPNLREYLHWLVTDIPGTTGATFGQEVMCYESPRPTMGIHRLVFVLFQQLGRQTVYAPGWRQNFSTRNFAELYNLGSPVATVYFNCQREAGSGGRRVYP
Probable mobile flower-promoting signal (florigen) that moves from the leaf to the shoot apical meristem (SAM) and induces flowering. Promotes the transition from vegetative growth to flowering under long day (LD) conditions. Acts upstream of MADS14 and MADS15. May also participate in the promotion of flowering under short day (SD) conditions.
Q8VWH2
B2T6J4
CLPS_PARPJ
ATP-dependent Clp protease adapter protein ClpS
Paraburkholderia
MAIIPDKQDGTVLERQEKKLKPPSMYKVVLLNDDFTPMEFVVMVVQEYFNKDRETATQVMLKVHREGRGVCGVYTRDIASTKVEQVVTHARQAGHPLQCVMEEA
Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.
B2T6J4
Q6EUP4
14335_ORYSJ
G-box factor 14-3-3 homolog E
Oryza sativa
MSQPAELSREENVYMAKLAEQAERYEEMVEFMEKVAKTVDSEELTVEERNLLSVAYKNVIGARRASWRIISSIEQKEESRGNEDRCTLIKEYRGKIETELSKICDGILKLLDSHLVPSSTAPESKVFYLKMKGDYYRYLAEFKTGAERKDAAENTMVAYKAAQDIALAELPPTHPIRLGLALNFSVFYYEILNSPDRACNLAKQAFDEAISELDTLSEESYKDSTLIMQLLRDNLTLWTSDISEDAAEEIKEAPKGESGDGQ
Is associated with a DNA binding complex that binds to the G box, a well-characterized cis-acting DNA regulatory element found in plant genes.
Q6EUP4
Q330G9
NU2M_SACBI
NADH dehydrogenase subunit 2
Saccopteryx
MNPLIFTMIMLTVILGTTIVMMSSHWLMIWMGFEMNMLAVIPLLMKQYNPRSMEAATKYFLTQATASMLLMLAVIINLLYSGQWTFTKLMNPTASIIMTLALGMKMGLAPFHFWVPEVTQGISLSSGLILLTWQKLAPLSVLYVISPAINLDLILLMSMMSIAIGGWGGLNQTQLRKILAYSSIAHMGWMASILVFNPTMTLLNLLLYILMTTTTFMLFMVASATTTLSLSHMWNKMPLITTSTLTIMLSLGGLPPLTGFLPKWMIIQELTKNNNITLATLMAITALLNLFFYMRLTYATSLTMFPTTNNMKMKWQFNNKKQLKCLPVLIILSTITLPLAPAITLLN
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
Q330G9