accession
stringlengths
6
10
name
stringlengths
6
11
Full Name
stringlengths
1
147
taxon
stringlengths
3
46
sequence
stringlengths
16
2.75k
function
stringlengths
6
5.51k
AlphaFoldDB
stringlengths
6
10
Q32CG3
CYSJ_SHIDS
Sulfite reductase [NADPH] flavoprotein alpha-component
Shigella
MTTQVPPSALLPLNPEQLARLQAATTDLTPTQLAWVSGYFWGVLNQQPAALAATPAPAAEMPGITIISASQTGNARRVAEALRDDLLTAKLNVKLVNAGDYKFKQIASEKLLIVVTSTQGEGEPPEEAVALHKFLFSKKAPKLENIAFAVFSLGDSSYEFFCQSGKDFDSKLAELGGERLLDRVDADVEYQTAASEWRARVVDALKSRAPVAAPSQSVATGAVNEIHTSPYSKDAPLVASLSVNQKITGRNSEKDVRHIEIDLGDSDLRYQPGDALGVWYQNDPALVTELVELLWLKGDEPVTVEGKTLPLNEALQWHFELTVNTANIVENYATLTRSETLLPLVGEKAKLQHYAATTPIVDMVRFSPAQLDAEALINLLRPLTPRLYSIASSQAEVENEVHVTVGVVRYDVEGRTRAGGASSFLADRVEEEGEVRVFIEHNDNFRLPANPETPVIMIGPGTGIAPFRAFMQQRAADEAPGKNWLFFGNPHFTEDFLYQVEWQRYVKEGVLTRIDLAWSRDQKEKVYVQDKLREQGAELWRWINDGAHIYVCGDANRMAKDVEQALLEVIAEFGGMDTEAADEFLSELRVERRYQRDVY
Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component.
Q32CG3
Q2IW74
PXPA_RHOP2
5-oxoprolinase (ATP-hydrolyzing) subunit A
Rhodopseudomonas
MKIDLNCDLGEGFGAWSMGDDAAMMRIATSVNVACGFHAGDPDIMHKTVAMAKAHGVAIGAHPGFRDLHGFGRRPVPGITAAEIENLVAYQIGALQAVASLAGHKVTHVKAHGALSNVACQDDMTARAIAAAIKAVDPKLIFVVLANSKLVDAGEAAGLAMVHEVFADRAYEDDGNLVSRRKPGAVLHDPAVIAERVLRMAQDGAVVSMTGKVIKMRTDTVCIHGDTAGAVDIARGVRTALEANGITVAPFARS
Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
Q2IW74
Q2YBP2
LPTD_NITMU
LPS-assembly protein LptD
Nitrosospira
MKLRFIRSAGWLFLLFCLACNARADLPPLSSKPEQGRATPSGEGDDKPVVIDTERIRGHHEYESGTRSESELRSRSTISTDQIKKPNQKADPAAKDTPSAPQQNYTLSPAIKTDSRTGTSAQESEKAESMVLPGGVERLPGPAAEEGEPRLRTRTQSAPRTLSAQKRGEKPAKTPAPAEADQDRPGFAEGERIGGHREEAGDEKLRLAGETEPEAIEQKLAEAEAETDKQSPVFVVADRLQGHVEEEIEAIGKAELSAGPQFISAERMKYNQGTNDAEAQGNVRVEKEGDILEGSDLKFNLLSKTGQLSEPSYRLKDASSRGYAGMLLFEGENQYRLQKASYTTCPVGDDSWVLQVADLKLDNDKKVGTAKNVKLTFKDVPILYTPWMNFSYSGERKSGLLAPTYGTGSRTGLELAVPFYWNIAPNYDATFSARLMSKRGLAINNEFRFLGQNSSSNLLADIVPRDLDTQTTRWRTSFWHNHYLGAGFSARLDYNRVSDATYFRDFGNNLNLTSRTNLLQQGLLSYNRGLGDDGTFNVTSLVQSFQTIQDPLAAIVVPYKRLPQVGLNANKPDVFGTGVDVNLSGSWTNFSHPTLVNGSRTVLFPSMSYPLRNSFGFITPKVGMHYTRYSLGEGAGVSEENPTRTLPIFSLDSGLAFDRKMSLGGESFTQTLEPRVFYVYVPFRAQDQLPNFDSAKTDFSFAQMLAENRFSGSDRINDANQVTFALTTRLLESSTGRERLRLAVGHQLSFIDRRITLETPQTIDRRPDFIAAVSGFLTPTISTDTSFQFDQTRLLADVVRSGVSYRPEPGRVLNFGYRFTRDVLHQVDASSQWRWSERWQTVARLNYSLQDKRILEGLAGVEYNACCWSLRFVLQHLTLATQKSTTAAFLQLELNGLMQIGSNPLTVLQRSIPGYIRTGSQGSGLIEGP
Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane.
Q2YBP2
Q0AQL8
MURA_MARMM
UDP-N-acetylglucosamine enolpyruvyl transferase
Maricaulis
MDRIVIQGGARLEGRIEISGAKNSALKLMAAALLTDEPVILTRMPRLADSRFLGHLLEKLGVEVSDGQDAQLRLHAATIADTFAPYDLVRKMRASFNVLGPLLAREGHARVSLPGGCAIGARPVDLHLKALKALGAQIEISEGYVSAKAPAGGLVGGEIDLPFASVGATEHAMLAASLARGETVIENAAREPEIGDLADCLTAMGATIEGAGSSTIRIQGQSRLSGVTHKVVADRIETATYALAVAAAGGDAVLEGAVLAHNKALWSSMGEAGVTVEAVADGVRVARNGSRLDSVDIETQPFPGFPTDAQAQFMALMSLANGSSVIRETIFENRFMHAPELARLGADITVHGNEAVVRGVERLRGAPVMATDLRASVSLVIAGLAAEGETVVNRVYHLDRGFERLEAKLTGCGARIERLPDGA
Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
Q0AQL8
B7HNP5
OTC_BACC7
Ornithine carbamoyltransferase
Bacillus cereus group
MSTVQVPKLNTKDLLTLEELTKEEIISLIEFAIYLKKNKQEPLLQGKILGLIFDKHSTRTRVSFEAGMVQLGGHGMFLSGKEMQMGRGETVSDTAKVLSQYIDGIMIRTFSHADVEELAKESSIPVINGLTDDHHPCQALADLMTIYEETNTFKGIKLAYVGDGNNVCHSLLLASAKVGMHMTVATPIGYEPNEEIVKKALAIAKETGAEIEILHNPELAVNEADFIYTDVWMSMGQEGEEEKYTLFQPYQINNELVKHAKQTYRFLHCLPAHREEEVTGEIIDGPKSIVFEQAGNRLHAQKALLVSLFKNVEELS
Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.
B7HNP5
Q7VGP6
MIAB_HELHP
tRNA-i(6)A37 methylthiotransferase
Helicobacter
MKLFIQTLGCAMNERDSAHMIAELRDKKHYTLTNDIKQADLILINTCSVREKPEKKLFSEIGAFAKEKKAGAKIGVCGCTASHLGEEIIKKAPSVDFVLGARNVSKITQVLERPKAVEVDIDYDDSTYVFASSQGMGIKAHLNISIGCDKKCSYCIVPFTRGKEISVPKDLLISEAKKCVASGAKELLLLGQNVNNYGVRFSHSHPKTNFTQLLRALSEIDGLYRIRFTSPHPLHMDDEFLEEFASNPVIAKGIHIPLQSGSSQILKMMRRGYDKQWYLNRIAKLKSLVPNVGIGTDIIVGFPTESEQDFEDTMEVLSLVEFDTLYSFVYSPRPHTSAFEYDKSMLVSPEVAKERLARLQNLHKEILSKKAQLEIGRIHNVLIENHYNGEGQCWSEGRSSSNKLIKILDKKCEIGSIVKVEITHNEGGGLMGRFINELSLSEALASKEYFQNPIYIQEGALC
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
Q7VGP6
Q95168
ZO2_CANLF
Zonula occludens protein 2
Canis
MEELIWEQYTVTLQKDSKRGFGIAVSGGRDNPHFENGETSIVISDVLPGGPADGLLQENDRVVMVNGTPMEDVLHSFAVQQLRKSGKIAAIVVKRPRKVQLAPPQGSLPVDEDDRAFEVMDEFDGRSARSGYSERSRRSSHGGRSRSWEDSPERGRPHERAWSQERERSRGRSLERGLDHDDDYRRPRERSRGRSLERGLDHDDDYGRPGERSHGMSTDRGYDRGYDRGYDRGYDRTYSPEAEYGRRTQPDARHAGSRSRSREHLRSRSPSPELRGRPDHAGQPDSDRPIGVLLMKSKANEEYGLRLGSQIFIKQMTRTALATKDGNLHEGDIILKINGTVTENMSLTDARKLIEKSRGKLQLVVLRDSKQTLINIPSLNDSDSEIEDISEIESNRSFSPEERRQQYSDYDYHSSNEKLKERPNSREDMQNRWSRMGATPTPFKSMGDIASVVGTENSKEPRYQEEPPAPQPKAAPRTFLRPSPEDEAIYGPNTKMVRFKKGDSVGLRLAGGNDVGIFVAGIQEGTSAEQEGLQEGDQILKVNTQDFRGLVREDAVLYLLEIPKGEMVTILAQSRADVYRDILACGRGDSFFIRSHFECEKETPQSLAFSRGEVFRVVDTLYDGKLGHWLAVRIGNELEKGLIPNKSRAEQMASVQNAQRDNAGDRADFWRMRGQRSGMKKNLRKSREDLTAAVSVSTKFPAYERVLLREAGFKRPVVLFGPIADIALEKLANELPDLFQTAKTEPKDAGSEKSSGVVRLNTVRQIIEQDKHALLDVTPKAVDLLNYTQWFPIVIFFNPDSRQGVKTMRQRLNPTSNKSSRKLYDQANKLKKTCAHLFTATINLNSANDSWFGSLKDTIQHQQGEAVWVSEGKMEGMDDDPEDRMSYLTAMGADYLSCDSRLISDFEDTDGEGGAYTDNELDEPAEEPLVSSITRSSEPVQHEESIRKPSPEPRAQMRRAASRDQLRDSSPPPAFKPEPPKAKTQNREESFDISRSHDYKSNPSAVAGNEVSGASTRSCPPPIAAKPSFGRSILKPSTPVPSPESEEVGEGSEEQEGAPKSVLGKVKIFEKMDHKARLQRMQELQEAQNARIEIAQKHPDIYAVPIKTHKPDPGLSQHTSSRPPEPQKGPSRLYQDPRGSYGSDAEEEEYRQQLSEHSKRGYYSQPSRYRDTEL
Plays a role in tight junctions and adherens junctions.
Q95168
C3K2V2
RS4_PSEFS
30S ribosomal protein S4
Pseudomonas
MARYIGPKCKLARREGTDLFLKSGVRAIESKCNIEAAPGIHGQRRGRQSDYGTQLREKQKVRRIYGVLERQFSGYYKEAAGKKGATGENLLQLLECRLDNVVYRMGFGSTRAESRQLVSHKSISVNGQTVNVPSYQVRAGDVVAVREKAKNQLRIVQALDLCAQRGRVEWVEVDTEKKSGVFKNVPARSDLSADINESLIVELYSK
With S5 and S12 plays an important role in translational accuracy.
C3K2V2
A6W5T0
RPOB_KINRD
Transcriptase subunit beta
Kineococcus
MEGPLLAASLPASAPNSTYIGNQSPRTVSGRYSFGKIHEPLEVPDLLALQTDSFDWLLGNKRWQDRVEASTNGGLAVPTTSGLEEIFEEISPIEDFSGSMSLSFRDHRFEPPKYSLDDCKERDLTYSAPLFVTAEFINGNTGEIKSQTVFMGDFPLMTDRGTFVINGTERVVVSQLVRSPGIYFERVPDKTSDRDTWTAKIIPSRGAWLEFEIDKRDTVGVRVDRKRKQSVTVLMKALGWSESQIREEFADYESMISTLEKDHTSGVEDALLDIYRKLRPGEPPTQEAARNLLDNLYFNPKRYDLAKVGRYKVNKKLGTEEPLSDSVLSVDDIVRTIKYLVKLHAGEVTMPGVKNGQPVDVRVEVDDIDHFGNRRLRSVGELIQNQVRTGLSRMERVVRERMTTQDVEAITPQTLINIRPVVASIKEFFGTSQLSQFMDQTNPLAGLTHKRRLSALGPGGLSRERAGMEVRDVHPSHYGRMCPIETPEGPNIGLIGSLSSYGRINPFGFIETPYRKIVDGVVSDEVEYLTADEEDAFVIAQANAPLDADSRFAEARVLVRAKGGETEFVPRDEVDYMDVAARQMVSVATAMIPFLEHDDANRALMGANMQRQAVPLVKSEAPLIGTGMEFRAAVDAGDVVVATKAGVATDVSADMITTSNDDGTSTTYKVAKFRRSNHGTAYNQQVVINEGDRVEVGTVLADGPSTDGGEMALGRNLMVAFMPWEGHNYEDAIILSQRLVQDDVLSSIHIEEHEVDARDTKLGPEEITRDIPNVAEEVLADLDERGIIRIGAEVRDGDLLVGKVTPKGETELTPEERLLRAIFGEKAREVRDTSLKVPHGETGTVIGVKVFDRDEGDELPPGVNQLVRVYVANKRKITDGDKLAGRHGNKGVISKILPVEDMPFLEDGTPVDVILNPLGVPSRMNVGQVLELHLGWIASRGWKIEGQPDWAKLIPEEIREAPAGSRIATPVFDGAREEEITGLLSSTIPTRDGDRLVGGDGKARLFDGRSGEPFPDPVAVGYMYILKLHHLVDDKIHARSTGPYSMITQQPLGGKAQFGGQRFGEMEVWALEAYGAAYALQELLTIKSDDVLGRVKVYEAIVKGENIPEPGIPESFKVLIKEMQSLCLNVEVLSSDGMAIEMRDSDEDVFRAAEELGIDLARREPSSVEEV
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
A6W5T0
P52327
RPOD_PSEPU
Sigma-70
Pseudomonas
MSGKAQQQSRIKELITRGREQGYLTYAEVNDHLPEDISDPEQVEDIIRMINDMGINVFESAPDADALLLAEADTDEAAAEEAAAALAAVETDIRRTTDPVRMYMREMGTVELLTREGEIEIAKRIEEGIREVMGAIAHFPGTVDYILGEYDRVNRGCRLSDVLSGYIDPDDNIAAPTEEVPIPGTKAAAAKEEADDDEEESEGGDDEEEPKAALTRSSQPSVSVRYPSSFSDHQGPEEKRSYPQGKRRALQALADLFMPIKLVPKQFEVLVERVRDALNRLRQQERAIMQLCVRDARMPRADFLRMFPSNETDQTWSGDLAKRNTKWAAALGEKDAAIVACQQKLIDLETETGLTVAEIKEINRRMSIGEAKARRAKKEMVEANLRLVISIAKKYTNRGLQFLDLIQEGNIGLMKAVDKFEYRRGYKFSTYATWWIRQAITRSIADQARTIRIPVHMIETINKLNRISRQMLQEMGREPTPEELGERMEMPEDKIRKVLKIAKEPISMETPIGDDEDSHLGDFIEDSTMQSPIYVATVESLKEATRDVLSGLTAREAKVLRMRFGIDMNTDHTLEEVGKQFDVTRERIRQIEAKAWRKLRHPTRSEHLRSFLDE
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.
P52327
Q9SBK9
CAL_BRARP
Agamous-like MADS-box protein CAL
Brassica
MGRGRVEMKRIENKINRQVTFSKRRAGLLKKAHEISILCDAEVSLIVFSHKGKLFEYSSESCMEKVLERYERYSYAEKQLKAPDSHVNAQTNWSMEYSRLKAKIELLERNQRHYLGEDLESISIKELQNLEQQLDTSLKHIRSRKNQLMHESLNHLQRKEKEILEENSMLTKQIKERESILRTHQNQSEQQNRSHHVAPQPQPQLNPYMISHQASPFLSMGGMYQGEDPTAVRRNRLDLTLEPIYNCNLGYFAA
Probable transcription factor that promotes early floral meristem identity in synergy with APETALA1, FRUITFULL and LEAFY. Is required subsequently for the transition of an inflorescence meristem into a floral meristem. Seems to be partially redundant to the function of APETALA1.
Q9SBK9
Q64WA9
QUEF_BACFR
PreQ(0) reductase
Bacteroides
MTELKEQLSLLGRKTEYKQDYAPEVLEAFDNKHPENDYWVRFNCPEFTSLCPITGQPDFAEIRISYLPDVKMVESKSLKLYLFSFRNHGAFHEDCVNIIMKDLIRLMDPKYIEVTGIFTPRGGISIYPYANYGRPGTKYEEMATHRLMNHE
Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
Q64WA9
A0KQ96
EFG_AERHH
Elongation factor G
Aeromonas
MARTTPIERYRNIGISAHIDAGKTTTTERVLFYTGVSHKIGEVHDGAATMDWMEQEQERGITITSAATTAFWSGMGKQFQPHRINIIDTPGHVDFTIEVERSMRVLDGAVMVYCAVGGVQPQSETVWRQANKYKVPRIAFVNKMDRTGANFLRCVEHIKTRLKGNPVPLQLNIGSEENFKGVIDLVKMKAINWSEADQGVSFDYEDVPAELLEKAQEMRMTLVEAAAEASEDLMEKYLGGEELTEEEIKKALRQRVLNNEIILVTCGSAFKNKGVQAMLDAVVDYLPAPTDVAAIDGLKLDGETKDERHASDDEPFAALAFKIATDPFVGNLTFFRVYSGVVNSGDSVLNSVKEKRERFGRIVQMHANKREEIKEVRAGDIAAAIGLKDVTTGDTLCDEKAPIILERMEFPEPVISIAVEPKTKADQEKMGLALGRLAQEDPSFRVWTDEESGQTIIAGMGELHLDIIVDRMRREFKVEANVGKPQVAYRETIRNTVKDIEGKHAKQSGGRGQYGHVVIDMYPLEEGKAYEFVNDIKGGVIPGEFIPGVDKGIREQLKSGPLAGYPVMDLGVRLHFGSYHDVDSSELAFKIAASMAFKAGFMKANPVLLEPIMKVEVETPEDYMGDVIGDLNRRRGLIEGMEDGPSGKIVRALVPLAEMFGYATALRSATQGRASYAMEFAKYHDAPTNVAQAVIEERKSK
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
A0KQ96
A8H0D4
PANB_SHEPA
Ketopantoate hydroxymethyltransferase
Shewanella
MSKITSSTLRTFKQEGKKFTALTAYDASFAGAFDSEGIDVLLVGDSMGMVLQGHSDTLPVTVEEIAYHTRCVRRGIERALLIADMPFMSYATPEQTMINATTLMQAGANMVKVEGGKWLLESVAMLTERGIPVCAHLGLTPQSVHVFGGFKVQGRDADNAQRILDEAKALEAAGAQLLVVECIPAPLAKAITDALTIPVIGIGAGKDTDGQILVMHDVLGISSGYIPRFSKNYLKQTGEIRAAVRAYIDEVAQGIFPGSEHTFN
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
A8H0D4
A1S566
KAD_SHEAM
Adenylate monophosphate kinase
Shewanella
MRIILLGAPGAGKGTQAQFIMEHYGIPQISTGDMLRAAVKAGTPLGLEAKKVMDAGQLVSDELIIGLVKERIAQDDCANGFLLDGFPRTIPQADAMAANGISIDHVIEIDVPDEEIVNRMSGRRVHPGSGRVYHVVFNPPKVEGKDDVTGEDLVIRPDDEESTVRKRLGIYHEQTKPLVDYYGKVAAEGNTKYTKFDGTQSVAEVSKLIQAALS
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
A1S566
Q6GGY2
Y1438_STAAR
DegV domain-containing protein SAR1438
Staphylococcus
MTKQIIVTDSTSDLSKEYLEANNIHVIPLSLTIEGASYVDQVDITSEEFINHIENDEDVKTSQPAIGEFISAYEELGKDGSEIISIHLSSGLSGTFNTAYQASQMVDANVTVIDSKSISFGLGYQIQHLVELVKEGVSTSEIVKKLNHLRENIKLFVVIGQLNQLIKGGRISKTKGLIGNLMKIKPIGTLDDGRLELVHNARTQNSSIQYLKKEIAEFIGDHEIKSVGVAHANVIEYVDKLKKVFNEAFHVDNYDINVTTPVISAHTGQGAIGLVVLKK
May bind long-chain fatty acids, such as palmitate, and may play a role in lipid transport or fatty acid metabolism.
Q6GGY2
Q338B0
HFA2C_ORYSJ
Heat stress transcription factor 6
Oryza sativa
MDPAAAGIVKEEMLESQQQQRQEDGGAAPRPMEGLHEVGPPPFLTKTYDLVEDPATDGVVSWSRAGNSFVVWDPHVFADLLLPRLFKHNNFSSFVRQLNTYGFRKVDPDRWEFANEGFLRGQRHLLKTIKRRKPPSNAPPSQQQSLTSCLEVGEFGFEEEIDRLKRDKNILITEVVKLRQEQQATKDHVKAMEDRLRAAEQKQVQMMGFLARAMRNPEFFQQLAQQKEKRKELEDAISKKRRRPIDNVPFYDPGETSQTEQLDSPYLFDSGVLNELSEPGIPELENLAVNIQDLGKGKVDEERQNQTNGQAELGDDFWAELLVEDFTGKEEQSELDGKIDGIDELAQQLGYLSSTSPK
Transcriptional activator that specifically binds DNA of heat shock promoter elements (HSE).
Q338B0
Q1IHJ4
DNLJ_KORVE
Polydeoxyribonucleotide synthase [NAD(+)]
Candidatus Koribacter
MSRTKDPAKQAEDLREKLRYHEHRYYVLDDPEISDADYDVMMNELKALEAKHPELLTPDSPTQRVGGKPREGFVKVAHSAPMLSLDNAYNEEELRDWARRVEELSGKAEIEYECELKLDGLSMALRYQDARFVLAVTRGDGSIGEDVTLNLRTVKSVPLGVSSATLKKTHMLGDFEVRGEVIFPTKSFEKMNEDREKQGLAKFANPRNAAAGAVRVLEPNITAQRRLDFYAYFLLVDGRVHIDRQSEALDTLEKLGFKVNSNRAVFKSIDDVLKFIHKKEEDREKLPYEIDGVVIKVNSTALWQRLGFTGKAPRWAIAYKYAARAAVTQVEDILVQVGRTGKLTPVAALKPVPIGGTTVSRATLHNMDEIDRLGLLIGDWVQVERGGDVIPKVVKVIDDKDHPRGKKKFKMPERCPECGGHVVRTEGEADHRCVNANCPAKLRESILHFASRGVMNIEGMGDSLVNQLVDRGLVKNVADIYELDEEKLLSLERMGKKSAQNILDEIKGTKKLPLERVIYGLGIRMVGERTAQFLAEHFGSLDGVMKATEEELLEVEEVGPRIAQSIHEFFAEPSNRELVKRLEAAGLQFKGVKKERGTALAGQTFVLTGSLPTYSRDEAKKLIEDAGGKVSGSVSKKTNYVVAGEEAGSKLDKARDLGVAVIDEDALKKLLGK
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.
Q1IHJ4
B7LVU3
APAH_ESCF3
Diadenosine tetraphosphatase
Escherichia
MATYLIGDVHGCYDELIALLHKVEFTPGKDTLWLTGDLVARGPGSLDVLRYVKSLGDSVRLVLGNHDLHLLAVFAGISRNKPKDRLTPLLEAPDADELLNWLRRQPLLQIDEEKKLVMAHAGITPQWDLQTAKECARDVEAVLSSDSYPFFLDAMYGDMPNNWSPELRGLGRLRFITNAFTRMRFCFPNGQLDMYSKESPEEAPAPLKPWFAIPGPVAEEYSIAFGHWASLEGKGTPEGIYALDTGCCWGGTLTCLRWEDKQYFVQPSNRHKDLGEGEAVAS
Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP.
B7LVU3
B2ATX1
GATA_PODAN
Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial
Podospora anserina
MLSRSGLRGARLRVVSLTSQRRLLNHFITHPPEPIPPPPPPAPSSSPSPKQFTLAVKDNIATTIPGLPTTCASGILSKSYVSPIEATIITQLRARGAVITGKTNLDEFGMGSHSIYSHYGPVSQDTPPETSAGGSSGGSAVAVANGEVELALGTDTGGSVRLPAAYTGIIGYKPSYGMISRYGVIPYANSLDTVGFLSKQINPLKELIIGERGLWKEHDSNDPTSLTTAARKRCAAQRRGYRSRQGQTTELEGLKFGIPLEYNIAELDPEIRDAWAAAAKRLQDAGARIVPVSLPTTKHALAAYYVIAPAEASSNLAKYDGVRYGARDAEGASDASAGGVLYASTRGKGFGEEVKRRILLGSYTLSSEAMDNYFIKAQRVRRLVRRDFNRVFALENPLQERETFELSDLPEEVEMEDKWGPEEVDFLLCPTAPTLAPKLKGVMEQQPVDAYMNDVFTVPASLAGLPAISVPMKVATEGAAGLQLIGQYWDDARLLDVADAVAKEVRT
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
B2ATX1
Q9LS09
ASF1B_ARATH
Silencing group A protein 1
Arabidopsis
MSSINITNVTVLDNPAPFVNPFQFEISYECLTSLKDDLEWKLIYVGSAEDETYDQVLESVLVGPVNVGNYRFVLQADSPDPLKIREEDIIGVTVLLLTCSYMDQEFIRVGYYVNNDYDDEQLREEPPTKVLIDKVQRNILTDKPRVTKFPINFHPENEQTLGDGPAPTEPFADSVVNGEAPVFLEQPQKLQEIEQFDDSDVNGEAIALLDQPQNLQET
Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly.
Q9LS09
B5F3C0
RL9_SALA4
50S ribosomal protein L9
Salmonella
MQVILLDKVANLGSLGDQVNVKAGYARNFLVPQGKAVPATKKNVEYFEARRAELEAKLADVLAAANARAEKINALETVTIASKAGDEGKLFGSIGTRDIADAVTAAGVDVAKSEVRLPNGVLRTTGEHEVNFQVHSEVFAKVIINVVAE
Binds to the 23S rRNA.
B5F3C0
Q8R3Y8
I2BP1_MOUSE
Probable RING-type E3 ubiquitin transferase IRF2BP1
Mus
MASVQASRRQWCYLCDLPKMPWAMVWDFSEAVCRGCVNFEGADRIELLIDAARQLKRSHVLPEGRSPGPPALKHPTSKDLASTGSQGSQLPPPQAQAQPSGTGGSVSGPDRYDRATSSSRLALPSPALEYTLGSRLANGLGREEAVAEGARRALLGSIPSLMPPGLLAAAVSGLGGRALTLAPGLSPARPLFGSDFEKEKQQRNADCLAELNEAMRGRAEEWHGRPKAVREQLLALSACAPFNVRFKKDHGLVGRVFAFDATARPPGYEFELKLFTEYPCGSGNVYAGVLAVARQMFHDALREPGKALASSGFKYLEYERRHGSGEWRQLGELLTDGVRSFREPAPAEALPQQYPEPAPAALCGPPPRAPSRNLAPTPRRRKASPEPEGETAGKMTTEEQQQRHWVAPGGPYSSETPGVPSPIAALKNVAEALGHSPKDPGGGGGSVRAGGASPAASSTTQPPAQHRLVARNGEAEVSPTAGAEAVSGGGSGTGATPGAPLCCTLCRERLEDTHFVQCPSVPGHKFCFPCSREFIKAQGPAGEVYCPSGDKCPLVGSSVPWAFMQGEIATILAGDIKVKKERDP
Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities. May act as an E3 ligase towards JDP2, enhancing its polyubiquitination. Represses ATF2-dependent transcriptional activation.
Q8R3Y8
A7HP99
PCKA_PARL1
Phosphoenolpyruvate carboxykinase (ATP)
Parvibaculum
MKQTGPYISKNGADKSGFKNLAATHWNYRPAALYEEAIRRGEGHVAANGPFVVKTGVHTGRSAKDKFIVRDASTEKTVWWDNNKSMTPEAFDLLHADMLKHAEGKELFIQDLFGGADQTHRLATRIYTEYAWHSLFIQNLLIEPKPEELGSFDPQFTIIDLPSFEADPEKYGVRTGTVIACNFAKRIVLIAGTSYAGEIKKSVFSMLNYELPPKRVMPMHCSANVGEEGDTAIFFGLSGTGKTTLSAVATRTLIGDDEHGWSENGVFNFEGGCYAKMIKLSAEAEPEIYAVTRRFGTVLENVVMDENTRELDLDSAALAENSRGAYPLSFIPNASATGRAPHPKNIIMLTADAFSVLPPVARLTPSQAMYHFLSGYTAKVAGTEKGVTEPEATFSTCFGAPFMSRHPTEYGNLLRDLIAQHKVSCWLVNTGWTGGVYGTGNRMPIKATRALLAAALDGSLNNVEFRTDPNFGFEVPVDVPGVDNKILNPRETWADKAAYDAQAQKLVKMFIENFAKFEAHVDPDVRAAAPAAARAAE
Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.
A7HP99
P32382
NADO_THEBR
NADH oxidase
Thermoanaerobacter
MTHFPNLFSEGRIGNLVIRNRIVMPPMATNLANEDGSVSQRLIDYYVARARGGVGLIILENVQVDYPQGKNVACQLRLDDDKYMAGFFELAEAVHSYGAKIFMQIHHAGRQTTPGITEGLQPVAPSPVPCSFLGTQPRELTINEIEEIIQKFVDAAVRAKGAMFDGIELHGAHGYLIGQFMSPRTNRRVDKYGGSFERRMRFPLEIIRRIKEAVGEDYPISFRFSADEFVEGGNTLEEGKQIAKMLEEAGVHVLHVSAGIYESMPTLLEPSRFEQGWRVYLAEEIKKVVNIPVITVGVIREPEFAEKIIAEGRADFVAVGRGLIADPEWPKKAKEGRQNEIRKCISCNIGCIGGRVFQNLRLRCTVNPVAGREGVYSEIKQAPVKKKVVVVGGGPAGMQAAITAAKRGHQVILYEKKQHLGGQLEIASASPGKAKIKWFRDWLEAELSRAGVEVRSGVTADAETIAALSPDYVILATGSEPVTPRIKGAEKENTFVFQAWDVLAGKVSFDKDEEVVVIGGGLVGCETAHYLAEKGAKVTIVEMLSDIAIDMEPISRFDMMQQFTKLGISARTGKVVTEILPRGVAAVGKEGKQDFIRAHKVVLAIGQSPVGNELKKTLEDKGIDVRVIGDAYNVGKIIDAVSSGFQVAWQI
Reduces a range of alternative electron acceptors.
P32382
Q14HR4
BIOB_FRAT1
Biotin synthase
Francisella
MTLQQIKEIYSRPLTELILQALEIHNKNFGNDIELCSLKSIKTGTCPEDCKYCPQSGHYNTSIEKHKLLDKDSILAEAKNAKDAGSKRFCMGAAWKHIPKKDFDQVAEIITEVKNLGLETCVTLGSINADEATKLKQAGLDYYNHNLDTSREFYPEIITTRKFEERIETIRNVANADINVCCGGILGMGESLDDRFNLLLELLQLPAAPKSIPINTLIPIKGTPLGDKYTNAQIDSFELVRFIATTRILFPQARLRLSAGRENMSLETQTLCFLAGINSIFYGNKLLTENNATVNSDNFLLAKLGLKSNAELC
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
Q14HR4
Q9AKP0
MURE_RICMO
UDP-N-acetylmuramyl-tripeptide synthetase
spotted fever group
MSHNLKQLFQQHKVKGLSINSKTVKDKDVFFAIKGRNTDGNAFIKDALSKGAVLVITDNKKNIVIDKVIYVKDVQAALHEAIEIFYPKKPKNLIAVTGTNGKSSVVSYIAQTHSLLGKKAASIGTIGVEIFGCDNLINDVPELTTLDYLSFRKIAHNLAENGIEYLVFEASSHGLDQARLREIKVNIACFTSFSQDHLDYHHTKENYLLAKLKLFINHLLPNGIAILNSDIEEIEFVKDYLHNHNIKFITVGKKGDLEITRINCSLKGQNINFTFNNREYNFNTPIIGSFQASNLLIAVLSMHYTGFAFDDVIDSLVEVKAVKGRMERIDNTNIFVDYAHTPDALEKALTELKNIKLHDSKLSVVFGCGGNRDKAKRSLMGQMAAKRADTIIITDDNPRNEDPKLIRAEIISGIEKADYTEIANREEAIKYGINNLKQDDILLVAGKGHENYQIIGDKKLPFDDAEVVRKCVKVCHPVA
Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
Q9AKP0
B6JN44
EFTU_HELP2
Elongation factor Tu
Helicobacter
MAKEKFNRTKPHVNIGTIGHVDHGKTTLSAAISAVLSLKGLAEMKDYDNIDNAPEEKERGITIATSHIEYETENRHYAHVDCPGHADYVKNMITGAAQMDGAILVVSAADGPMPQTREHILLSRQVGVPHIVVFLNKQDMVDDQELLELVEMEVRELLSAYEFPGDDTPIIAGSALRALKKAKAGNVGEWGEKVLKLMAEVDAYIPTPKRDTEKTFLMPVEDVFSIAGRGTVVTGRIERGVVKVGDEVEIVGIRATQKTTVTGVEMFRKELEKGEAGDNVGVLLRGTKKEEVERGMVLCKPGSITPHKKFEGEIYVLSKEEGGRHTPFFTNYRPQFYVRTTDVTGSITLPEGVEMVMPGDNVKITVELISPVALELGTKFAIREGGRTVGAGVVSNIIE
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
B6JN44
A1CAP4
ARGJ_ASPCL
Arginine biosynthesis bifunctional protein ArgJ beta chain
Aspergillus subgen. Fumigati
MAAFARMVKGQVRNYSAPLDMAIPASKQKYIPSSGSYPKGFLVSGTHVGVKASNTRFPDLALISSETPCSAAAVFTTNKFQAAPVQVSKKTLQERQGQGIRSVVINSGCANAVTGKGGYEDAVNMGKKVDECEGLSKPSTLVMSTGVIGQRLPISKILDKIPTAYANLASTHEAWLTTARAICTTDTFPKLLSRTFTLPSSPGHTYSLAGMTKGAGMIHPNMATLLGVLCTDAPIAPSALQSLLKYAVSRSFNSISVDGDTSTNDTIAVLANGAAGGAPINSASSDDYAAMQEILTSFAQSLSQLVVRDGEGATKFVTVRVQNSPDYDSARLIASTIARSPLVKTALYGRDANWGRILCAIGYTQGVAPGTVVPERTSVSFKPVDGSAVLKLLVNGEPEQVDEERASAILQEEDLEIVVDLGGGEKGELGGEEAVYWFCDFSHEYVTINGDYRT
Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of acetylglutamate from glutamate and acetyl-CoA, and of ornithine by transacetylation between acetylornithine and glutamate.
A1CAP4
Q0TA26
MALK_ECOL5
Maltose/maltodextrin import ATP-binding protein MalK
Escherichia
MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQQVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV
Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Responsible for energy coupling to the transport system.
Q0TA26
Q57607
Y142_METJA
UPF0332 protein MJ0142
Methanocaldococcus
MRLKIMELRYKRELEKLIEKAEKSLEASENLYNSEFYDFAVSRIYYSMFYCVKALLLTKEINPKKHSGVLKMFAKEFIKTNELDVELFEYINEAYNYRQTADYDATIEIKKEEAEYLLHKGHIFLNKTKKYLISKNILKGENDNTKS
Putative toxin component of a putative type VII toxin-antitoxin (TA) system. Its cognate antitoxin might be MJ0141.
Q57607
O35492
CLK3_MOUSE
CDC-like kinase 3
Mus
MPVLSARRKRLASTAGPRRGSGPSLAVRWVPPLGPEPSSDRGRAPMRPRGPTCSTTRRGAGRGPRLLPGPPGRDLHRCRPDPGGAGQSPRVCEFGARAVRPLGRVEPGPPTAASREGAVLPRAEARAGSGRGARSGEWGLAAAGAWETMHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRIPYQRRYREHRDSDTYRCEERSPSFGEDCYGSSRSRHRRRSRERAPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHSSRNPSR
Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.
O35492
A6VA58
RIMO_PSEA7
Ribosome maturation factor RimO
Pseudomonas
MSTPTPKVGFVSLGCPKALVDSERILTQLRMEGYEVVPTYEDADVVVVNTCGFIDSAKAESLEVIGEAIAENGKVIVTGCMGVEEHAIRDVHPSVLAVTGPQQYEQVVTAVHEVVPPKTEHNPLIDLVPPQGIKLTPRHYAYLKISEGCNHSCSFCIIPSMRGKLVSRPVGDVLSEAERLVKAGVKELLVISQDTSAYGVDLKYKTDFWNGQPVKTRMKELCEALGGMGVWVRLHYVYPYPNVDDVIPLMAAGKLLPYLDIPFQHASPKVLKAMKRPAFEDKTLARFKHWREICPELTIRSTFIVGFPGETEEDFQYLLDWLTEAQLDRVGCFQYSPVEGAPANELGLEPVPDEVKQDRWERFMAHQQAISAARLQLKVGKEIEVLIDEVDEQGAVGRSWADAPEIDGNVFVDSDALKPGDKVRVRITDADEYDLWAEPV
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
A6VA58
Q9LVT4
DRL37_ARATH
Probable disease resistance protein At5g47250
Arabidopsis
MNCCWQVVEPCYKSALSYLCVKVGNICMLKENLVLLKSAFDELKAEKEDVVNRVNAGELKGGQRLAIVATWLSQVEIIEENTKQLMDVASARDASSQNASAVRRRLSTSGCWFSTCNLGEKVFKKLTEVKSLSGKDFQEVTEQPPPPVVEVRLCQQTVGLDTTLEKTWESLRKDENRMLGIFGMGGVGKTTLLTLINNKFVEVSDDYDVVIWVESSKDADVGKIQDAIGERLHICDNNWSTYSRGKKASEISRVLRDMKPRFVLLLDDLWEDVSLTAIGIPVLGKKYKVVFTTRSKDVCSVMRANEDIEVQCLSENDAWDLFDMKVHCDGLNEISDIAKKIVAKCCGLPLALEVIRKTMASKSTVIQWRRALDTLESYRSEMKGTEKGIFQVLKLSYDYLKTKNAKCFLYCALFPKAYYIKQDELVEYWIGEGFIDEKDGRERAKDRGYEIIDNLVGAGLLLESNKKVYMHDMIRDMALWIVSEFRDGERYVVKTDAGLSQLPDVTDWTTVTKMSLFNNEIKNIPDDPEFPDQTNLVTLFLQNNRLVDIVGKFFLVMSTLVVLDLSWNFQITELPKGISALVSLRLLNLSGTSIKHLPEGLGVLSKLIHLNLESTSNLRSVGLISELQKLQVLRFYGSAAALDCCLLKILEQLKGLQLLTVTVNNDSVLEEFLGSTRLAGMTQGIYLEGLKVSFAAIGTLSSLHKLEMVNCDITESGTEWEGKRRDQYSPSTSSSEITPSNPWFKDLSAVVINSCIHLKDLTWLMYAANLESLSVESSPKMTELINKEKAQGVGVDPFQELQVLRLHYLKELGSIYGSQVSFPKLKLNKVDIENCPNLHQRPL
Probable disease resistance protein.
Q9LVT4
Q89AK6
BIOF_BUCBP
8-amino-7-ketopelargonate synthase
Buchnera
MNWNKRINHKLNMHIFNKKFRVKVAVQKNNNRIINVNGMQYINFSSNDYLGLRNNARIVQAWKTAATRYGIGSTGSSLITGYSTIHQSLEEKLAKWLDYPKAILFISGYTANTAIISTLIQKNDRIFMDKLSHSSILEPSYNSSGKCYRFIHNNPSSLMNKFYSSSGKNPLIITEGIFSMDGDIAPLSIISSFSKKIKGLLMVDDAHGIGVSGYNGKGSCEQHRVKPDILTITFGKAFGISGAAVLCSNNIAEYLWQFSKHLMFSTAMPIAQAYAIRQALYCIQHADKLRRKLQENINFFLKNSQCLSHLLKCSHTAIQPIIIGDNEETMILSDQLKSKGIWVNAIRPPTVPNKSSRLRITLNALHTKEDIEQLIESIYKLYDR
Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
Q89AK6
Q68FQ2
JAM3_RAT
Soluble form of JAM-C
Rattus
MALSRRLRLRLCARLPDFFLLLLFRGCVIEAVNLKSSNRNPVVHEFESVELSCIITDSQTNDPRIEWKKIQDGQTTYVYFDNKIQGDLAGRTDVFGKTSLRIWNVTRSDSAIYRCEVVALNDRKEVDELTIELIVQVKPVAPVCRVPKAVPVGKAATLQCQESEGYPRPYYSWYRNDVPLPTDSRANPRFQNSSFHVNSETGTLVFSAVHKEDSGQYYCIASNDAGAARCEGQDMEVYDLNIAGIIGGVLVVLIVLAVITMGICCAYRRGCFISSKQDGESYKSPGKHEGVNYIRTSEEGDFRHKSSFVI
Promotes chemotaxis of vascular endothelial cells and stimulates angiogenesis.
Q68FQ2
A0Q7L0
DNLJ_FRATN
Polydeoxyribonucleotide synthase [NAD(+)]
Francisella
MTPNEFFSIKYHILAKAELKAYIDKLADYLSQQSYLYHTLDKPIISDSDYDKLFRLLQDLVNDNPQFKPINSVLDRVGGEVLAEFETIKHKKKMTSLANVFSLEELRDFYDKIEYDIELECEPKMDGLAISIFYKNGKFDYAVTRGDGIQGEKVSENVKTIRNVPLKLNTSNPPEELEVRGEIILDKQSFLSLNEYMQTHENKTFANPRNAAAGSIRMLDSKVVAKRPLKLYSYGIGYFSKDFVHPETQFELMQLLQSFGFTISDNMFLAKNFSEVEEYHHKMSHQRADLAYDIDGLVFKVNNIKLQDIIGYTARGPKWAVAYKFPAEEVESEVLNVEFQVGRTGAITPVARLKPVAVGGVIVSNATLHNINEIKRKDIRVGDRVIVRRAGDVIPEVVKSLPQYRKSDAQMVEMPTNCPVCDSAIENVNDQAIYRCTGGWHCQAQTTERLKHFVSRKAMDIDKLGAKLIEQLVAANLIKYPADIYKLNFDQLTGLERMGAKSSQNVLDSIKKSKTPSLARFIFAIGIKDIGEVSSDVLANHFGSLESFRDAKFEELIEINDIGEIMANNIVSFWHDSLNIKIVEELLAIGIKIQNPVKVEHAYNESFTGKTVVITGSFENYGRTELTQLLKSIGAKVTSSVSKKTDMVICGDNAGSKLTKAQELGVEVILEDNLKDLL
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.
A0Q7L0
P04781
CB23_PETSP
LHCII type I CAB-22R
unclassified Petunia
MAATTMALSSSSFAGKAVKLSSSSSEITGNGKVTMRKTVTKAKPASSSSPWYGPDRVKYLGPFSGEAPSYLTGEFPSDYGWDTAGLSADPETFAKNRELEVIHCRWAMLGALGCVFPELFARNGIKFGEAVWFKAGAQIFSEGGLDYLGNPSLVHAQSILAIWACQVVLMGAVEGYRVAGGPLGEVIDPLYPGGSFDPLGLAEDPEAFAELKVKEIKNGRLAMFSMFGFFVQAIVTGKGPLENLADHLADPVNNNAWSYATNFVPGK
The light-harvesting complex (LHC) functions as a light receptor, it captures and delivers excitation energy to photosystems with which it is closely associated.
P04781
Q31NV7
UCRI_SYNE7
Rieske iron-sulfur protein
Synechococcus
MTQVSGASDVPSMGRRQFMNLLTFGSVTGVALGALYPVVNYFIPPSSGGSGGGVAAKDALGNDVVLSKFLADHNVGDRTLVQGLKGDPTYLVVESSEAIGDYGINAVCTHLGCVVPWNASENKFKCPCHGSQYDATGKVVRGPAPLSLALAHVSVTDDKVFLSPWTETDFRTGDNPWWA
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
Q31NV7
B8F4R6
FDHE_GLAP5
Protein FdhE homolog
Glaesserella
MSIRILPQEEIQQAASSFHNPPLLYANPKNLYARRAKRLRQLAEHNPFGDYLEFVANIVEVQLDLLENQPIANRVGELTAYLEAHQGVKPLDVKTFKRSDEWQKLLLAFIDKFKPYASDTVLATLEWLEKASNSELEMLADHLLNECYEEVGADKAVFLWAVLSLYWVQLTQQLPRNTKAEYGEERHTCPVCNSAPIASVVHFGETQGLRYLHCSLCESEWNMVRAKCSNCEQTGKLDYWSLDSMDAAVKAESCGDCESYLKVMYQDKDPHVEPIADDLGTLFLDAEMEQKGLARSAINPFLFQVE
Necessary for formate dehydrogenase activity.
B8F4R6
Q9I558
ACSA1_PSEAE
Acyl-activating enzyme 1
Pseudomonas
MSAASLYPVHPEAVARTFTDEATYKTMYQQSVVNPDGFWREQAQRIDWIKPFEKVKQTSFDDHHVDIKWFADGTLNVSHNCLDRHLAERGDQVAIIWEGDDPADHQEITYRQLHEQVCKFANALRGQDVHRGDVVTIYMPMIPEAVVAMLACTRIGAIHSVVFGGFSPEALAGRIIDCKSKVVITADEGVRGGKRTPLKANVDDALTNPETSSVQKIIVCKRTGAEIKWNQHRDVWYDDLMKVAGSTCAPKEMGAEDPLFILYTSGSTGKPKGVLHTTGGYLVYASLTHERVFDYRPGEVYWCTADIGWVTGHTYIVYGPLANGATTILFEGVPNYPDVTRVAKIIDKHKVNILYTAPTAIRAMMAEGKAAVAGADGSSLRLLGSVGEPINPEAWQWYYETVGQSRCPIVDTWWQTETGACLMTPLPGAHAMKPGSAAKPFFGVVPALVDNLGNLIEGAAEGNLVILDSWPGQARTLFGDHDRFVDTYFKTFKGMYFTGDGARRDEDGYYWITGRVDDVLNVSGHRMGTAEVESAMVAHPKVAEAAVVGMQHDIKGQGIYVYVTLNSGVEPSEALRQELKQWVRREIGPIATPDVIQWAPGLPKTRSGKIMRRILRKIAAAEYDTLGDISTLADPGVVQHLIETHRSMQAA
Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
Q9I558
Q8UDA0
RL25_AGRFC
General stress protein CTC
Agrobacterium tumefaciens complex
MSKESYELKAEARERVGKGSSRELRRNGLIPAVIYGDKQAPISIALSTNEVTKRIHAGGFMTTVGTIDVDGKKIKVLPKDYQLDPVRDFTMHVDFLRVSGNTLVNVEIPVHFENEEKSDIKIGGVLNIVRHTVEFHCPANDIPEAITVDLSGLKIGDSVHISNVKLPKNITPVIADRDFTIATIVAPAAGVEEETTEEASEE
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
Q8UDA0
C4ZSG3
MDTB_ECOBW
Multidrug transporter MdtB
Escherichia
MQVLPPSSTGGPSRLFIMRPVATTLLMVAILLAGIIGYRALPVSALPEVDYPTIQVVTLYPGASPDVMTSAVTAPLERQFGQMSGLKQMSSQSSGGASVITLQFQLTLPLDVAEQEVQAAINAATNLLPSDLPNPPVYSKVNPADPPIMTLAVTSTAMPMTQVEDMVETRVAQKISQISGVGLVTLSGGQRPAVRVKLNAQAIAALGLTSETVRTAITGANVNSAKGSLDGPSRAVTLSANDQMQSAEEYRQLIIAYQNGAPIRLGDVATVEQGAENSWLGAWANKEQAIVMNVQRQPGANIISTADSIRQMLPQLTESLPKSVKVTVLSDRTTNIRASVDDTQFELMMAIALVVMIIYLFLRNIPATIIPGVAVPLSLIGTFAVMVFLDFSINNLTLMALTIATGFVVDDAIVVIENISRYIEKGEKPLAAALKGAGEIGFTIISLTFSLIAVLIPLLFMGDIVGRLFREFAITLAVAILISAVVSLTLTPMMCARMLSQESLRKQNRFSRASEKMFDRIIAAYGRGLAKVLNHPWLTLSVALSTLLLSVLLWVFIPKGFFPVQDNGIIQGTLQAPQSSSFANMAQRQRQVADVILQDPAVQSLTSFVGVDGTNPSLNSARLQINLKPLDERDDRVQKVIARLQTAVDKVPGVDLFLQPTQDLTIDTQVSRTQYQFTLQATSLDALSTWVPQLMEKLQQLPQLSDVSSDWQDKGLVAYVNVDRDSASRLGISMADVDNALYNAFGQRLISTIYTQANQYRVVLEHNTENTPGLAALDTIRLTSSDGGVVPLSSIAKIEQRFAPLSINHLDQFPVTTISFNVPDNYSLGDAVQAIMDTEKTLNLPVDITTQFQGSTLAFQSALGSTVWLIVAAVVAMYIVLGILYESFIHPITILSTLPTAGVGALLALLIAGSELDVIAIIGIILLIGIVKKNAIMMIDFALAAEREQGMSPREAIYQACLLRFRPILMTTLAALLGALPLMLSTGVGAELRRPLGIGMVGGLIVSQVLTLFTTPVIYLLFDRLALWTKSRFARHEEEA
The MdtABC tripartite complex confers resistance against novobiocin and deoxycholate.
C4ZSG3
Q58EG3
NECT3_DANRE
Poliovirus receptor-related protein 3-like
Danio
MALTMTAHFLRNNPIQLGLNLRVLLMLSFVSGLVYGSQVIVPPKVNAVLGKNVTLSCRVQVDTNLSLTQSSWERKLPNGWVTLAVYNPMFGISIPPDYERRLSFRSPSALDATIMLEDVGFADIGVYTCKVATFPLGNTQASTTVSVLVEPKVYVSAGSSALIDGGNETTVATCIAERARPPADVSWETNLYGMSEAHMQEDANGTTTTQVHYIWQPSRHAQGHTLTCVVKHPALQSDFRIPYIINVQFAPDILVLGYDGDWYVGRENVQLKCRAKANPPAQHFRWIRLDGEMPNGAERVNNTLVFTRPLQKNDSGVYRCEVANDIGLHSRDIRIRIQDPPSTTTMPPTTPVRLLTADISATAPGNKQRALITSPTLAPLHEGSLGTIVGGAVGGALFLLLLLILAGVYYQRQRRTFRGDYYTKQYHGPSDMQKAPQPHELQQVYSKGSPDTKLKSNQDNGTIYPDKDREEWGDFDRERSPNGRSRALREAGQLNHHNHQNHEHGFHSNHHTGHPQSYSPAHHIQRSSLQPQPRRYPAPQVMSNGSPYLPEDCYDNEYVSHTDGSMISRREWYV
May play a role in cell-cell adhesion.
Q58EG3
P0A521
CH602_MYCBO
Heat shock protein 65
Mycobacterium tuberculosis complex
MAKTIAYDEEARRGLERGLNALADAVKVTLGPKGRNVVLEKKWGAPTITNDGVSIAKEIELEDPYEKIGAELVKEVAKKTDDVAGDGTTTATVLAQALVREGLRNVAAGANPLGLKRGIEKAVEKVTETLLKGAKEVETKEQIAATAAISAGDQSIGDLIAEAMDKVGNEGVITVEESNTFGLQLELTEGMRFDKGYISGYFVTDPERQEAVLEDPYILLVSSKVSTVKDLLPLLEKVIGAGKPLLIIAEDVEGEALSTLVVNKIRGTFKSVAVKAPGFGDRRKAMLQDMAILTGGQVISEEVGLTLENADLSLLGKARKVVVTKDETTIVEGAGDTDAIAGRVAQIRQEIENSDSDYDREKLQERLAKLAGGVAVIKAGAATEVELKERKHRIEDAVRNAKAAVEEGIVAGGGVTLLQAAPTLDELKLEGDEATGANIVKVALEAPLKQIAFNSGLEPGVVAEKVRNLPAGHGLNAQTGVYEDLLAAGVADPVKVTRSALQNAASIAGLFLTTEAVVADKPEKEKASVPGGGDMGGMDF
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
P0A521
Q5FRW6
ATPL_GLUOX
Lipid-binding protein
Gluconobacter
MDVQAAHEFGISIAQAARDLGAGIAVFALAGVGMGLGNIFSTLISSVARNPASRPHVFGIGMLGFALTEAVALFALLIAFLILFA
Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
Q5FRW6
Q3UFY0
RRP36_MOUSE
Ribosomal RNA processing protein 36 homolog
Mus
MRKAGSRARAEAEGPHRAMEGGEVTGDRLKADTPDVSFEELLRLQGQGRPKAHKQLVAGNSTRTRSPQQPVCVADKHRPLEMSAKVRVPFLRQVVPISKKVARDPRFDDLSGDYNPEVFDKTYQFLNDIRAKEKQLVKKQLKRHRSGEERDKLQQLLQRMEQQEMAQQERKQQQELRLALKQERRAQAQQGHRPYFLKKSEQRQLALAEKFKELRRSKKLESFLSRKRRRNAGKDRRHLPLSKE
Involved in the early processing steps of the pre-rRNA in the maturation pathway leading to the 18S rRNA.
Q3UFY0
P00756
K1KB3_MOUSE
Nerve growth factor gamma chain 2
Mus
MWFLILFLALSLGGIDAAPPVQSRIVGGFKCEKNSQPWHVAVYRYTQYLCGGVLLDPNWVLTAAHCYDDNYKVWLGKNNLFKDEPSAQHRFVSKAIPHPGFNMSLMRKHIRFLEYDYSNDLMLLRLSKPADITDTVKPITLPTEEPKLGSTCLASGWGSITPTKFQFTDDLYCVNLKLLPNEDCAKAHIEKVTDAMLCAGEMDGGKDTCKGDSGGPLICDGVLQGITSWGHTPCGEPDMPGVYTKLNKFTSWIKDTMAKNP
7S NGF alpha chain stabilizes the 7S complex. The beta dimer promotes neurite growth. The gamma chain is an arginine-specific protease; it may also have plasminogen activator activity, as well as mitogenic activity for chick embryo fibroblasts.
P00756
C3PMH5
RL10_RICAE
50S ribosomal protein L10
spotted fever group
MLRSEKPVAVEDIVNIYKESPSIIITHYHGLTVSQVSSLRESLKSKEAGFKVVKNTLAKIAANQTGLNSIVNLFAGPTAIVYSKEPVEMAKLVVNFAKANDNLKIIGGIVDNHVLDEHSIKELSKLPTLNELRGKIVGLLQAPATKVVGVLQAPSSSMARVIQAHASKN
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
C3PMH5
Q057A2
EFTU_BUCCC
Elongation factor Tu
Buchnera
MSKEKFNRSKPHINVGTIGHVDHGKTTLTSAITTVLSKRFGGKACAFEQIDNAPEEKARGITINTSHVEYDTELRHYAHVDCPGHADYIKNMITGAAQMDGAILVVAATDGPMPQTREHILLGRQVGVPHIIVFLNKCDMVDDEELLELVEMEVRDLLTQYDFPGDNIPIIRGSALKALEGEKIWEDKIIELANSLDKYIPIPVRAVDEPFLLPIEDVFSISGRGTVVTGRIERGILKVGEEVEIVGIKSTTKTICTGVEMFRKLLDEGRAGENVGILLRGTKREDIERGQVLAKPGTINPHVKFESEVYVLSKEEGGRHTPFFKGYRPQFYFRTTDVTGSIELPENIEMVMPGDNINMVVTLIHPIAMAEGLRFAIREGGRTVGAGVVTKVIA
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
Q057A2
A4PBQ1
CRJ38_CRYJA
Pathogenesis-related thaumatin-like protein 3.8
Cryptomeria
MAKVSDLALLLVAGMAISLYIQETGAVKFDIKNQCGYTVWAAGLPGGGQQLTQGQTWTVNLAAGTQSARFWGRTGCSFDASGKGTCQTGDCGGQLSCTVSGAVPATLAEYTQSDQDYYDVSLVDGFNIPLSINPTNAQCTAPACKADVNAVCPAELKVDGGCKSACAAFQTDQYCCTGTYANSCPATNYSMIFKNQCPQAYSYPKDDTATFACPSGTDYSIVFCP
May be involved in disease resistance.
A4PBQ1
Q1GK13
RL18_RUEST
50S ribosomal protein L18
unclassified Ruegeria
MANSKRTLFLKRRLRVRNKLRKVNAGRLRLSVHRSNKNISVQLIDDVKGVTLAAASTLEKDLGFVGKNNIEAATKVGSVIAERAKAAGVTEAYFDRGGFLYHGKVKALADAAREGGLKI
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
Q1GK13
Q47TA8
PLSX_THEFY
Phosphate-acyl-ACP acyltransferase
Thermobifida
MSSPVTAQRPPAAPPLIAVDAMGGDHAPREIVAGAVRAVREHGLRLALVGRSSELAPLVAAEQAARELPIVHAEEALAMHEGALAAWRRARSSVAVGCKLVRQGTAAALVSAGSTGGVVSTATVRLRTLPGVLRPALALVLPTTPTPTILLDAGANADAKPEMLVQFAHLGAAYARVGHGIAEPRVGILTIGSEPGKGNKLARRAAELLSANATEDRLDFRGNIEGHDLLAGLVDVVVTDGFTGNVALKSVEGAVRFAFDEIRAALTSSPLARFGTLFQRRALRELRTRFDSETYGGAVLLGLNGTVVIAHGASRAEGIAHACLLAHNLVVGRITDQIRRGIAGVSRTPSWLHRLSAPEE
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
Q47TA8
Q5FFT9
RS10_EHRRG
30S ribosomal protein S10
Ehrlichia
MVMVTQKIYIELKAFDSYLLDRSARSIILTAKRSGARVNGPIFFPRRVAKFIVNRSTHVDKKSREQFEIRTHKRLISLPKANSTIIQALMSLQLPAGVDVKVKVIGGSNG
Involved in the binding of tRNA to the ribosomes.
Q5FFT9
Q31FZ5
TGT_HYDCU
tRNA-guanine transglycosylase
Hydrogenovibrio
MKFELDKQDGRARRGRLIFKRGVVETPAFMPVGTYGSVKGMMPEEVADTGAQIILGNTFHLSIRPGTDIIEQHGDLHDFMNWKGPILTDSGGFQVFSLGKMRKITEEGVHFRNPVNGSKIFMGPEESMDVQRKLGSDIVMIFDECTPYPATHDVAADSMRLSLRWAERSKQAHGDNPSALFGIVQGGMYEDLRQESIKGLTDIGFDGYAIGGLSVGEPKEEMMGTLDFTEPHMPKDKPRYMMGVGKPEDIVEAVRRGIDMFDCVIPTRNARNGFLFTHSGVVKIRNAVNKTSLEPLDAKCDCYTCQNYTRAYLHHLDKCGEIQGARLNTIHNLHYYQLLMKGLREAIASETLDTFVSEFYQARGEDVPAL
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
Q31FZ5
Q32RS5
RR14_STAPU
30S ribosomal protein S14, chloroplastic
Staurastrum
MAKKSMIERDKKRKFLSAKYSIQRQQLKEQINQSLSLDEKAHLYRKLQSLPRNSAPTRITRRCFVTGRPKAVYRDFGLSRHVLREMAHACLLPGVIKASW
Binds 16S rRNA, required for the assembly of 30S particles.
Q32RS5
Q96JN2
CC136_HUMAN
Nasopharyngeal carcinoma-associated gene 6 protein
Homo
MQAMEGEVLLPALYEEEEEEEEEEEEVEEEEEQVQKGGSVGSLSVNKHRGLSLTETELEELRAQVLQLVAELEETRELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQIQQLQGELRSLREEISLLEHEKESELKEIEQELHLAQAEIQSLRQAAEDSATEHESDIASLQEDLCRMQNELEDMERIRGDYEMEIASLRAEMEMKSSEPSGSLGLSDYSGLQEELQELRERYHFLNEEYRALQESNSSLTGQLADLESERTQRATERWLQSQTLSMTSAESQTSEMDFLEPDPEMQLLRQQLRDAEEQMHGMKNKCQELCCELEELQHHRQVSEEEQRRLQRELKCAQNEVLRFQTSHSVTQNEELKSRLCTLQKKYDTSQDEQNELLKMQLQLQTELRQLKVMKSTLVENQSEKELLCRLQKLHLQHQNVTCEKEKLLERQQQLQEELQCHEAELQHLRDTVASFKESNEKDTETHAQLQEMKQLYQASKDELERQKHMYDQLEQDLLLCQLELKELKASHPIPEDKGKCANKCDTLLSRLTELQEKYKASQKEMGQLQMEQCELLEDQRRMQEEQGQLQEELHRLTLPLPKSGLLLKSQELLTKLEDLCELQLLYQGMQEEQKKLIQNQDCVLKEQLEIHEELRRFKESHFQEVLENPDDSKLAKSSKCNRNKQSKLLMEQMQALQVMYDAGQAKQELLQQEQGRLLEERKRLQADLQLCLEEMQLLQVQSPSIKMSLESYGKSYGSMVPSNENCRKTYDTTVDDNESYYKSYTSTQTSSKSFLKSYDSSTSASEAYGKSYCTTSNSSITYKKSYGSTSSSDTCQKSFVSSCTDEEPAEPEDMERFEEMVVKVLIKLQAVQAMYQISQEEHSQLQEQMEKLLAKQKDLKEELDACEREFKECMECLEKPMAPQNDKNEIKELQTKLRELQLQYQASMDEQGRLLVVQEQLEGQLQCCQEELRQLREKRPSVVKEARGKNANKNMNKNANGVKMKKVTKPCSDTSESDLETRKSLEVVLYYKASQRKLDGLAKEEEKKEEMEEEKKQVKEEAKEQCGDELVAEPADPEEAKSTEDQEENEEDKEEEEKEEDSEEEEDDADSSLESPEENNPLRLSESKKSSPTPNPPIFSLPLVGLVVISALLWCWWAETSS
May play a role in acrosome formation in spermatogenesis and in fertilization.
Q96JN2
P66366
RS11_TROW8
30S ribosomal protein S11
Tropheryma
MSKQAQSRSRKKARKNIPAGLAHIKSTFNNTIVTITDLSGNVIGWSSSGAVGFKGSRKSTPYAAQMAADAAARSAQEHGVKKVDVFVKGPGSGRETAIRSLQTAGLEIGSISDTTPLAFNGCRPPKKRLV
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
P66366
B1XP88
PYRR_SYNP2
Uracil phosphoribosyltransferase
unclassified Synechococcus
MTKSVIEILSAEEMRRTITRLASQIVEKAGDLTDLALLGIHTRGVPLAENIAKQIETLEGIAVPVGALDITFYRDDLDQIRVRTPSKTDIPFDLNGKNLVLIDDVIYKGRTIRAALNAVNDYGRPEVIRLAVLVDRGHRQLPIQPDFTGKKLPTAKEEKVKVYLQDLDGRDAVELIK
Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
B1XP88
Q9Z6T7
FTSY_CHLPN
Signal recognition particle receptor FtsY
Chlamydia
MFKFFRNKLQSLFKKNISLDLIEDAESLFYEADFGTELTEELCARLRRTKKADASTIKDLITVLLRESLEGLPSQASQSSQTRPIVSLLLGTNGSGKTTTAAKLAHYYKERSESVMLVATDTFRAAGMDQARLWANELGCGFVSGQPGGDAAAIAFDGIQSAIARGYSRVIIDTSGRLHVHGNLMKELSKIVSVCGKALEGAPHEIFMTVDSTLGNNAIEQVRVFHDVVPLSGLIFTKVDGSAKGGTLFQIAKRLKIPTKFIGYGESLKDLNEFDLDLFLNKLFPEVEKI
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
Q9Z6T7
A8GVB8
RS19_RICB8
30S ribosomal protein S19
belli group
MARSVWKGPFVDGYLIKKVQKLMESGKSEMIKTWSRRSTILPIFVGFTFSVHNGNKFIPVSVNEEMVGRKLGEFSPTRTFHGHGADKKVKRK
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
A8GVB8
Q2GCU4
MIAB_NEOSM
tRNA-i(6)A37 methylthiotransferase
Neorickettsia
MLLYLADVVIFSHAKVYMEKIEKKNNSLKKFHIKTYGCQMNVYDSEMIEKIVSGLGFTLSERAEDADLIILNTCNIREKAAEKLYSELGQIRLLQKKKQERILIVVAGCVAQAEGEEIMRRAENVDVVVGPQSIHSLPELIAKVNRQSGKAIKMEFDPIEKFDYLAEETRKRRVPQSSAFLSIQEGCDKFCAFCVVPYTRGAEYSRSTEEVYREALSLTTKGVKEITLLGQNVNGYHGTLDSGNKVLNLGQLISRLGKIPSLKRIRYTTSHPVDMHKELYDAHANESKLMPFVHLPVQSGSDKILKQMNRKYTTADYLKIINEFQNARSDIAFSSDFIVGFPGESDDDFQQTLALIEQVNYAQCYSFKYSPRPGTPGATYPQISEETKNTRLQKLQQLLKEKQLEFNKKMIGKTVTVLFDKKHPDKISGRTEYMQQVFSDDSNLLDKIVTMRVEDASTFTLKCTAEDIIST
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
Q2GCU4
A7FIA5
MINC_YERP3
Probable septum site-determining protein MinC
Yersinia
MSQSPIELKGSSFTLSVVHLHDSRPEVIRQALQEKVDQAPAFLKNAPVVINVATLPNGANWKDLQQAVTSAGLRIVGISGCQDERQKRAIARAGLPLLSEGKGQKLAPEPVISPPENVPTQTRIINTPVRSGQQIYARNCDLIVISSVSAGAELIADGNIHIYGMMRGRALAGASGDAKCQIFCTHLGAELVSIAGQYWLSDQIPLEYFGQAARLYLQDNTLTIQPLN
Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization.
A7FIA5
Q9C7D2
SCP15_ARATH
Serine carboxypeptidase-like 15
Arabidopsis
MASWIFKLLLLLQCVLVLIQHADSSSIIRYLPGFEGPLPFELETGYIGVGQKEEDQLFYYFIKSENNPEEDPLLVWLTGGPGCSSFSGLVYENGPLAFKVETYNGSVPTLVSTTYSWTKVANIIYLDQPVGTGFSYSRNPFADIPSDTGSVKRVNEFVRKWLAKHPEYFSNPFYVTGNSYSGKVIPAIVQEISNGNYICCKPQINLQGYVIGNPVAYYDHDKDFRIPFAHGVALISDELFESLKASCGGSYSVVDPLNTECLKLIEDYDKCVSGIYEELILKSKCEHTSPDCYTYRYLLSEYWADNETVRRALKVVKGSKGTWERCDYRVLSNQDIKSSIPFHINNSIRGYRSLVISGDHDMTIPFLGTQAWIRSLNYSITEKWRPWMILDQVAGYTKTYANKMTLATVKGGGHTLEYKPEENSVLFKRWISGQPL
Probable carboxypeptidase.
Q9C7D2
A9AHS8
DAPE_BURM1
N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase
Burkholderia cepacia complex
MSATLALTEQLIARASVTPDDQHCQQIMTERLAALGFDCETVASHGVTNLWAVKRGTDGRDGKLLAFAGHTDVVPTGPLEQWTSPPFVPAHRDGKLYGRGAADMKTSLAAFVVAAEEFVAAHPDHRGAIAFLITSDEEGPATDGTVKVVELLESRGERLDYCIVGEPTSTAELGDVVKNGRRGSMSGELIVKGVQGHIAYPHLAKNPIHLLAPALAELAAEQWDEGNEYFPPTTWQVSNLRAGTGATNVIPGHADLLFNFRFSTASTVEGLQARVHAILDKHQLDYTLKWTVSGLPFLTPRGELSNALEHAIRAETGLTTELSTTGGTSDGRFIARICPQVIEFGPPNGSIHKIDEHIEVRFVEPLKNVYRRVLEQLIA
Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
A9AHS8
Q3BZD0
KDUI_XANC5
DKI isomerase
Xanthomonas
MSLYCKTHYATHPDAIKGASNDALRELYLLDGLFVDDAVTLKYTHYERFVLGGAAPLGKTLELPRQTEPASAAGHPFLERRELGVLNVGAGTGTVTVDGTAYTLGPKDGLYVAMGSTDVSFASADAANPAKFYLASTPAHARFETKQLSIKDAVALERGALETSNERTIYQYIVPATCQSSQLLLGLTVLKPGSVWNTMPPHLHDRRSEVYFYFDLGANDRVYHFMGEPDAQRHIVIQNNEAVVSPPWSIHMGAGTSNYAFIWAMGGENLDYTDMHVLDICQLK
Catalyzes the isomerization of 5-dehydro-4-deoxy-D-glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate.
Q3BZD0
P80725
DPS_LISIN
Non-heme iron-containing ferritin
Listeria
MKTINSVDTKEFLNHQVANLNVFTVKIHQIHWYMRGHNFFTLHEKMDDLYSEFGEQMDEVAERLLAIGGSPFSTLKEFLENASVEEAPYTKPKTMDQLMEDLVGTLELLRDEYKQGIELTDKEGDDVTNDMLIAFKASIDKHIWMFKAFLGKAPLE
Protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral. One hydrogen peroxide oxidizes two Fe(2+) ions, which prevents hydroxyl radical production by the Fenton reaction. Does not bind DNA.
P80725
A6VQ42
RNFC_ACTSZ
Rnf electron transport complex subunit C
Actinobacillus
MTDVLTRYNSGKLWDFDGGIHPPEMKSQSNSTPISTALLAEDYYVPVKQHAGNAGNLLVKEGDYVLKGQPLTLGDGLRVLPVHAPTSGTVVAIEPHIAAHPSGLSELAVHIHADGKDQWRPQNPTEDYFTHTPERLIEKIYRAGVAGLGGAVFPTGAKVDAALGKVKLLIINGAECEPYITCDDRLMRDYAAEIIEGVRILRYILRPEKVVIAIEDNKPEAVNALRTSLQGANDMDIRVIPTKYPSGAAKQLIYVLTGMEVPHGQRSSSIGVLMQNVGTAFAVKRAVINDEPLIERVVTLTGDKIPHKGNQWVRLGTPIDFILKHVGYQPDNRFPVFVGGPMMGLIVPDLRAPITKTANCLLAPDHFEYDPQATEQACIRCSACSDACPVHLMPQQMYWYARAEDHEKSNQYQLMDCIECGLCAYVCPSHIPLIQYFRQEKAKIWDIEAKARKSEEAKIRFEARQARLEREEQARKARSQRAAAARREELAANKGEDPVQAALARLKAKKAGEAPETGGSAQGAPHIKTIRTEKGQSVPDNSEITALRRARRLARQQTNGNSPVSSASNSDSATISADNTHSTPKTAQNQTAPDPKKAAVAVAIARAKAKKAAQTTTGETVTENVTEKTAQNPTAPDPKKAAVAAAIARAKAKKAAQATTGETATEKTAQNPTAPDPKKAAVAAAIARAKAKKAAMLAESEKK
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
A6VQ42
Q2FTN5
RL13_METHJ
50S ribosomal protein L13
Methanospirillum
MVVVIDGDGLLLGRLASNVAKRALAGEEIAVVNAEKAVISGNRARVLGNYKQKRQRGSREGGPFFPRRPDHILKRTIRGMIPYKRERGIEAMKRIRIYVGVPDELSGQPFETIEDASKKRLGNPSHVTLGAVSTFLGAKY
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.
Q2FTN5
A3NT04
PURT_BURP0
Phosphoribosylglycinamide formyltransferase 2
pseudomallei group
MQIGQRLGTPLSPSATRVMLLGAGELGKEVIIALQRLGVEVIAVDRYPNAPGHQVAHRAHVIDMTDPDALRALVDAERPHLVVPEIEAIATDALAAIEAAGVCEVIPTARATQLTMNREGIRRLAAEELGLPTSPYAFAQSFDEFAAAVARIGFPCVVKPVMSSSGKGQSVVRSEADIEPAWRYAMAGGRVNHGRVIVEGFIRFDYEITQLTVRAIDPASGQTRTSFCAPIGHLQVAGDYVESWQPQPMSAKALERSRDIAHRVTSALGGRGIFGVELFVRGDDVWFSEVSPRPHDTGLVTLASQRQSEFELHARAILGLPVEPALATPAASAVIYGGLDEAGIAFEGVRDALAVPGADLRLFGKPESFAKRRMGVALATGANVDEARERAKRAAAAVRPVSAR
Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.
A3NT04
A1S3I3
HLDE_SHEAM
D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase
Shewanella
MKVTLPAFEKARVLVVGDVMLDRYWVGPTGRISPEAPVPVVRINQIEDRPGGAANVALNIAALGGKVQLSGLVGQDDTADALTRGVQALGVEPHWLVVEDKPTITKLRVLSRNQQLIRLDFEEAFDKHSSDALLNQAQARLDDVDVVILSDYAKGAVGEPADFIASARAKGVKVLVDPKGSDFARYRGATLLTPNMSEFEAVVGTVTSEADLVDKAQKLLQDLALDALLVTRSEKGMTLITPNAPELHIPTVAREVYDVTGAGDTVISALATALGAGAELPQACAIANTAAGVVVGKLGTSTVSRIELIEALKSHQGESGIGVVSEDQLVYALEQAKLRGERVVMTNGCFDILHAGHVSYLAQAKALGDRLIVAVNDDDSVRRLKGDGRPVNSVDRRMAVLAGLASVDWVVPFSEDTPQRVIARLLPDLLVKGGDYKVEDIAGGAEVIANGGQVKVLGFEDGVSTTAIIQNIMSRH
Catalyzes the ADP transfer from ATP to D-glycero-beta-D-manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose.
A1S3I3
Q96QP1
ALPK1_HUMAN
Lymphocyte alpha-protein kinase
Homo
MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT
Serine/threonine-protein kinase that detects bacterial pathogen-associated molecular pattern metabolites (PAMPs) and initiates an innate immune response, a critical step for pathogen elimination and engagement of adaptive immunity . Specifically recognizes and binds ADP-D-glycero-beta-D-manno-heptose (ADP-Heptose), a potent PAMP present in all Gram-negative and some Gram-positive bacteria . ADP-Heptose-binding stimulates its kinase activity to phosphorylate and activate TIFA, triggering pro-inflammatory NF-kappa-B signaling . May be involved in monosodium urate monohydrate (MSU)-induced inflammation by mediating phosphorylation of unconventional myosin MYO9A . May also play a role in apical protein transport by mediating phosphorylation of unconventional myosin MYO1A . May play a role in ciliogenesis .
Q96QP1
A0LJL8
NUON2_SYNFM
NDH-1 subunit N 2
Syntrophobacter
MNWMSFAPELITLTSALWFLLLSMTARSDPKREHVAALVLSALGLAACLASVGAEGYCFAGAYKVDLFSQVFKVLLAAGLFLIVTLCGELSDIEERNRREFYVLLFVCTLAMMLLVGANHFLVVFISLELSSYSLYVLVALRRDRGLGLEAGIKYFLVGIFASGVMIFGLALLYGASGIAALDGMARVLPGIIHQPAVVIGLLLTLSGFFFKLAVFPFHFWAPDAYQGAANQVSAYIATASKVAAIGVLVRVIASAGDGGTYLVHVLAVLSVVSMTVGNLAAIAQQDLKRLLAYSTVAHAGYVLIGVLSMNPAGYSAAVFYAFALLVMKFTAFLVLVEVASDGGNLRVEELAGLHRRSPILALALMVSLFSLAGIPPTVGFTGKFLVFVAAMGEGHFTLVLIAMINVVISLYYYLLVIKAAYLLEPRQELPALRVSPPLKLLSGVLVIAMVAAGFFPNQIIRVAESAAKALL
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
A0LJL8
Q487Z3
RL3_COLP3
50S ribosomal protein L3
Colwellia
MTIGLVGRKVGMTRVFTEDGVSTPVTVIEVEANRVAQVKTVDNDGYSALQVTTGKRKASRVTKPAAGHFAKAGIEAGRGLWEFRLNENEGSDIEAGSEITVEVFNDTKLVDVTGTSKGKGFQGGIKRWNFTMQHATHGVSLSHRSNGSLGQCQTPGRVFKGKKMSGHMGAVRCTTQNLELVRVDAERNLLLIKGAVPGAINGNVIIKPAVKA
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
Q487Z3
A9ADK7
RS8_BURM1
30S ribosomal protein S8
Burkholderia cepacia complex
MSMSDPIADMLTRIRNAQMVEKVSVAMPSSKVKVAIAQVLKDEGYIDDFAVKTEGAKAELNIALKYYAGRPVIERLERVSKPGLRVYRGRNEIPQVMNGLGVAIVSTPKGVMTDRKARATGVGGEVICYVA
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
A9ADK7
C0HLD7
PLS21_PHYTB
Phylloseptin-2.2TR
Phyllomedusa
FLSLIPHIATGIAALAKHL
Has antimicrobial activity against Gram-negative bacterium E.coli ATCC 25922 (MIC=50 uM), Gram-positive bacterium S.epidermidis ATCC 12228 (MIC=12.5 uM) and against fungus C.albicans ATCC 24433 (MIC=100 uM) . Has an anti-inflammatory effect, since it inhibits the production of the pro-inflammatory cytokines TNF-alpha, and induces the production of the anti-inflammatory cytokine IL-10 . Is cytotoxic to cancer line cells . Shows moderate hemolysis on mouse erythrocytes (LC(50)=41 uM) .
C0HLD7
Q8IIJ6
UCH37_PLAF7
PfUCH54
Plasmodium (Laverania)
MARDNENILEEWCLIESNPCIFYDMLKRMGATEISVEDVYSLSYFDDYINNKEIINMNHILGVDTYLGENNKTLDKENNVVDVIELYKNNICMEDKYNKLLKHHSYIYGIIFLFNIGKHYKNNKYIEHNVPDNLFFAKQVIPNACATQAILSIVLNKDIELNDEIKNIKTFSLNFDSSMKGLTLSNCTFLRNIHNSYKPPIYLDKEDVHHDKKKSEDSFHFVSYISFQDKVYLLDGLQSGPVLINADEQNKPNPNNNNNNKDNDNDNNNNNNNNNNNNNNNNNNNNNNNNNNIGMNGKDWIEISREHIKKEIDEICNSQTNNDVRFNIIAVMKDKEYIIQEYINIHRIVKQRVNIKLINLGENIELSDEINEDEFPLLNDIPSIENLPNNVDTLYNIVNKSTLEINYLQSLLHEQKEIKKLWNKELTFKFFNFYPFIMSSLNLMAKHKLLKDAYQKEKLKNATKS
Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8.
Q8IIJ6
A8GPC4
RS20_RICAH
30S ribosomal protein S20
spotted fever group
MANHSSAKKAARQTVKRTLINKARSSAIKTFIKKVVHEISLGNKENANLALSVAQSKIMQGVKKNIIKLNTASRKISRLSKQIKSLNESK
Binds directly to 16S ribosomal RNA.
A8GPC4
O36028
ATCZ_SCHPO
Putative phospholipid-transporting ATPase C4F10.16c
Schizosaccharomyces
MPSLINFDAISSLKSSLHGLSICAFNHLHHVPQHNGSLAHEGPTNQTDYSSRHHESQFSQEAHAEQRSRDDEEANSFEGSCNNSDQSWTSRVTSKKNEAGTESGDASVRRIYVTSIPEEHRHLPSQWFPSNKIRTTKYTPVSFIPKNLWNQFKNIANAFFLFVTLLQCIPLFCPEHLGLSFIPLSVILLTTAIKDGIEDYRRCVLDKKFNNTLTWKLVGFNNANALGEHIGLWRKLKKFISHTVADMSYCLKNSGISSGLATLTVDNISHRHSLESDSAFTLSSVSQDSLEIHEIGNSGPSNSFSVIQEQSTGSSNAKFERVCRKSLLVGDIVKVLADEAIPADLLILSTENSNGVCYVETKNLDGETNLKDKYALCSTKCCKSEYRCSAASFWVECEQPHADLYSLNGVVKAPGAVQSPSESTNGRKIHEEPFSISNVLLCGCTLRNSKWVIGLVLYTGSETRIQKNRGLTPSKRSRITRDLNWTIILNFLLLFAMCLFSGVLRSIYSAQNNSARVFELSKNSNTAPAHGIISIFTSLILFQNLVPISLYITMDIVRSIQSYFIFSDREMYDEKLDCPCSPKSWNISDDLGQIEYIFSDKTGTLTQNIMSFKKCSINGIRYGKSHNEDTCIKKRRNLNYNENLSCKVDLDKKKMLETLSLSDSPNPESITFISSKFVDHLQSNENYIQTEACFEFFKALALCHSVVTDVQDETLIYNAQSPDEEALVKVARDFGFTLLNTKNRRYTIRIRGENKNFRVLDIIPFTSTRKRMSVIIRDEDGIIHLICKGADTVIFPRLSSGQNNIIEKTKKHLASFSSEGFRTLCIARRTIDKQDYLEWKVNFNEANSAIHERNEKVSKVSEMIEQELELLGGTAIEDKLQENVPETIALLAIAGIKLWVLTGDKVETAINIGYSCNLLDPNMTIFRIDANSFGALEEVEAFIRNTLCFNFGYMGTDEEFRFLLKDHSPPSPKHAIVIDGDALNFVLSEQVSFLFLMLCKQCKTVLCCRVSPSQKAAVVALVKKSLNVVTLAIGDGANDVSMIQEADVGVGIKGVEGQAASMSADYAIGQFSFLGRLLLVHGRWDYKRMSQMISFFFYKNVIWTFILFWYQFYNEFDGNYIFDYTYVMLFNLLFTSLPVIIAGCFDQDVDASVSMKNPSLYQRGILGLEWNGKRFWSYMLDGIYQSLVCFGVALFVFKFGDFVSWTGRNIECIEDIGLFISSPTIFVINIFILMNQERLNLISLITWMFSIGVFWIWTFIYSEVGPSYAFHKSASRTCQTFGFWCVTVLTIALCLLPRFSYICLQKLFYPRDIDLLRRRLCAKSDDETSSSSSFATDIEMCEQCNDPLSSKKNSGIVTSVSFDDSNK
Catalyzes the hydrolysis of ATP coupled with the transport of phospholipids.
O36028
Q98QJ9
NAGB_MYCPU
Glucosamine-6-phosphate isomerase
Mycoplasmopsis
MREIYIFKDLQDLHKFSAKQIIDQIKIKKDSTLGFATGKTPLKTYQLLVKDHQENKTSWKDITSFNLDEFVDIDPSHPESFIKQMKSNLFDHLDINEQKINIPKSNSSNPDQEALNYENKIRKNNGIDLQFISIGVNGHIAYNEPGTPKDSLTHVSNLTKETILDLIAKNKFSSIDEVPKKAITMGVKTILNQCKKIMMVSFGKEKAQVTKQMLEDKPNENVTASFLQEHPNCIYILDKEAASLLNEETLKKAKWI
Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
Q98QJ9
P52726
MT_OREMO
null
Oreochromis
MDPCECAKTGTCNCGGSCSCTKCSCKSCKKSCCDCCPSGCSKCASGCVCKGKTCDTSCCQ
Metallothioneins have a high content of cysteine residues that bind various heavy metals.
P52726
Q3AAQ2
DEOB_CARHZ
Phosphodeoxyribomutase
Carboxydothermus
MKRVVLIVLDSVGIGELPDAHLYGDEGSNTLANTAKKVGGFELPNLEKLGLGKIHPILGLKGDIKALGAYGKMGEKSPGKDTTTGHWEICGLILEKPFPVYPNGFPEDLIKRFEEAIGRKTLGNKPASGTAIIEELGEEHMRTGYPIVYTSADSVFQIAAHEEVIPLEELYKMCKIARGLLTGEHAVGRVIARPFTGTPGNFKRTANRHDYSLEPTGKTVLDKLVEQGYEVLGVGKIYDIFAGRGLTWHESTKNNEDGLVKTVNLLYKDFTGLLFTNLVDFDMVYGHRNNAEGYYEALKQFDSYLPKIMEKLREDDLLIITADHGCDPTTPSTDHSREYVPLLVYGHSIKEDVNLGTRETFADVAATLEEIFGLEPGIGQSFWGEIRK
Phosphotransfer between the C1 and C5 carbon atoms of pentose.
Q3AAQ2
P61490
CH60_THET2
Heat shock protein 60
Thermus
MAKILVFDEAARRALERGVNAVANAVKVTLGPRGRNVVLEKKFGSPTITKDGVTVAKEVELEDHLENIGAQLLKEVASKTNDVAGDGTTTATVLAQAIVREGLKNVAAGANPLALKRGIEKAVEAAVEKIKALAIPVEDRKAIEEVATISANDPEVGKLIADAMEKVGKEGIITVEESKSLETELKFVEGYQFDKGYISPYFVTNPETMEAVLEDAFILIVEKKVSNVRELLPILEQVAQTGKPLLIIAEDVEGEALATLVVNKLRGTLSVAAVKAPGFGDRRKEMLKDIAAVTGGTVISEELGFKLENATLSMLGRAERVRITKDETTIVGGKGKKEDIEARINGIKKELETTDSEYAREKLQERLAKLAGGVAVIRVGAATETELKEKKHRFEDALNATRAAVEEGIVPGGGVTLLRAISAVEELIKKLEGDEATGAKIVRRALEEPARQIAENAGYEGSVIVQQILAETKNPRYGFNAATGEFVDMVEAGIVDPAKVTRSALQNAASIGALILTTEAVVAEKPEKKESTPASAGAGDMDF
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
P61490
Q9CIV9
DHAS_LACLA
HTH-type dhaKLM operon transcriptional activator DhaS
Lactococcus
MSAFFLNMKKSIITQKIIAKAFKDLMQSNAYHQISVSDIMQTAKIRRQTFYNYFQNQEELLSWIFENDFAELINDNSDYYGWQNELLLLLRYLDENQIFYQKIFVIDKNFEHFFLIQWENLLDKVIFDQEKKSDYHWSDLEKSFICRYNAAAICAITRESIIRGNSLEKLYSQIVNLLLAQIKIFES
In complex with DhaQ, upon activation by dihydroxyacetone, activates transcription of the dhaKLM operon. Binds the inverted repeat sequence 5'-GGACACATN(6)ATTTGTCC-3' located upstream of and partially overlapping with the -35 promoter sequence of the dhaKLM operon promoter.
Q9CIV9
Q0SNY5
MNME_BORAP
tRNA modification GTPase MnmE
Borreliella
MSKLFERDDDIVALATPFLSSALCVIRSSGASSISKFSKIFSNHSALNSAAGNTIHYGYILDNENNCKVDEVVVCLYRAPKSFTGQDAVEVIAHGSVIGIKKIIDLFLKSGFRMAEPGEFTFRSFLAKKIDLTKAEAINEIIFAKTNKAYSLAVNKLSGALFVKIDTIKKCILNFLSAVSVYLDYEVDDREIDIPFDLILNSKVELKKLIDSYKVYEKIDHGITLVLAGSVNAGKSSLFNLFLKKDRSIVSSYPGTTRDYIEASFELDGILFNLFDTAGLRDADNFVERLGIEKSNSLIKEASLVIYVIDISSNLTRDDLLFIDSNKSNSKILFVLNKIDLKINKSTEEFVRSSVLNSSNLIMISIKNLEGIDILYDKIRTLISYERVEIGLDDIIISSSRQIQLLEKAYALILDLLSKIDRQVSYDMLAFDAYEIINCLGEITGEVSSEDVLDNMFKNFCLGK
Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
Q0SNY5
Q1IIT5
RBFA_KORVE
Ribosome-binding factor A
Candidatus Koribacter
MEQRALKHHRERLGEAIREEIGAILEGELGDPRIGLVTVSEVMIASNGKSAIVLVAVAGEEQEAVDTLEGLAAATGYIRHEVAARLGLRVAPELLFRLDQTERYGGRVEELLKRVNKRKKSSR
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.
Q1IIT5
P57298
MUTT_BUCAI
dGTP pyrophosphohydrolase
Buchnera
MELLSKKKVYITRGKYKKNIWEFPGGKVKKHENIVHALKRELLEEVGIIVLKINFFQYIEYIYPEKKIKLYFFLKKKWKGRPYSIEGYTYLWKRLCHLRALDFPLANHSVINALKKNNILIKFR
Specifically hydrolyzes both 8-oxo-deoxyguanosine triphosphate (8-oxo-dGTP) and 8-oxo-guanosine triphosphate (8-oxo-GTP) to the related monophosphates, thereby cleaning up the nucleotide pools and preventing misincorporation of 8-oxoGua into DNA and RNA. It prevents replicational errors by removing an oxidatively damaged form of guanine (8-oxo-dGTP) from DNA and the nucleotide pool. 8-oxo-dGTP can be inserted opposite dA and dC residues of template DNA with almost equal efficiency thus leading to A.T to G.C transversions.
P57298
A0JTZ0
FOLD_ARTS2
Methenyltetrahydrofolate cyclohydrolase
Arthrobacter
MAQAAKILDGKAAAAAIKSELAERVAKLKARGVTPGIATVLVGADPASQLYVSMKHKQSVEIGMNSIQRELPADATQAQVEALIDELNADPACHGYIVQLPLPKHLDTDAILERIDPAKDADGLHPTNLGRLVLNVSGEITSPLPCTPRGVIELLERNGYSLSGKHVVVVGRGVTIGRTIGLLLTRRSVNATVTLTHTGTENLSQLLRQADVIVGAAGAKHIVKAADVKPGAALLDVGVTRETDPETGKSKVHGDIDPAAAEVAGWISPNPGGVGPMTVALLMTNVVEAAERKLAAESAGTA
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
A0JTZ0
O43896
KIF1C_HUMAN
Kinesin-like protein KIF1C
Homo
MAGASVKVAVRVRPFNARETSQDAKCVVSMQGNTTSIINPKQSKDAPKSFTFDYSYWSHTSTEDPQFASQQQVYRDIGEEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGRQEPGQQGIVPQLCEDLFSRVSENQSAQLSYSVEVSYMEIYCERVRDLLNPKSRGSLRVREHPILGPYVQDLSKLAVTSYADIADLMDCGNKARTVAATNMNETSSRSHAVFTIVFTQRCHDQLTGLDSEKVSKISLVDLAGSERADSSGARGMRLKEGANINKSLTTLGKVISALADMQSKKRKSDFIPYRDSVLTWLLKENLGGNSRTAMIAALSPADINYEETLSTLRYADRTKQIRCNAIINEDPNARLIRELQEEVARLRELLMAQGLSASALEGLKTEEGSVRGALPAVSSPPAPVSPSSPTTHNGELEPSFSPNTESQIGPEEAMERLQETEKIIAELNETWEEKLRKTEALRMEREALLAEMGVAVREDGGTVGVFSPKKTPHLVNLNEDPLMSECLLYHIKDGVTRVGQVDMDIKLTGQFIREQHCLFRSIPQPDGEVVVTLEPCEGAETYVNGKLVTEPLVLKSGNRIVMGKNHVFRFNHPEQARLERERGVPPPPGPPSEPVDWNFAQKELLEQQGIDIKLEMEKRLQDLENQYRKEKEEADLLLEQQRLYADSDSGDDSDKRSCEESWRLISSLREQLPPTTVQTIVKRCGLPSSGKRRAPRRVYQIPQRRRLQGKDPRWATMADLKMQAVKEICYEVALADFRHGRAEIEALAALKMRELCRTYGKPDGPGDAWRAVARDVWDTVGEEEGGGAGSGGGSEEGARGAEVEDLRAHIDKLTGILQEVKLQNSSKDRELQALRDRMLRMERVIPLAQDHEDENEEGGEVPWAPPEGSEAAEEAAPSDRMPSARPPSPPLSSWERVSRLMEEDPAFRRGRLRWLKQEQLRLQGLQGSGGRGGGLRRPPARFVPPHDCKLRFPFKSNPQHRESWPGMGSGEAPTPLQPPEEVTPHPATPARRPPSPRRSHHPRRNSLDGGGRSRGAGSAQPEPQHFQPKKHNSYPQPPQPYPAQRPPGPRYPPYTTPPRMRRQRSAPDLKESGAAV
Motor required for the retrograde transport of Golgi vesicles to the endoplasmic reticulum. Has a microtubule plus end-directed motility.
O43896
Q2W2L1
KAD_MAGSA
Adenylate monophosphate kinase
Magnetospirillum
MNLVLLGPPGGGKGTQAKRLQDKYGLVQLSTGDMLRAAVASGSEVGKKAKAVMDAGQLVSDEIVIAIIDERLDQADVAKGAIFDGFPRTVAQAEALDAMMAKKGKKLDFAIEIRVPDAYIVERITGRYTCAKCGAGYHDKFQLPQVAGKCDSCGGTEFARRPDDNVDTVTKRLDAYHAQTAPLLPYYDKKGSLKLVDGTMDIADVTKALEGILDASK
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
Q2W2L1
O58665
PANB_PYRHO
Ketopantoate hydroxymethyltransferase
Pyrococcus
MREITPKRIREMKGKEKITMITAYDYPSALLADKAGFDIVFIGDSLGMVVYGEPSTLNVTMEQMIFHTRAVAKAVKRALVLADMPFGSYEVSVEEGIKNAIKLVQAGADAVKIEGGYDHRKLVKKLVRIGIPVMGHTGLTPQRYLRLGGYRIMGGTEEEVEEILRDAKALEKAGAFAIVLEFVLADVAKLVTEEVSIPTIGIGSGPYVDGQVLVWHDVLGLYESSPPFAKRYANLKEEILRAISTFREEVKEGKFPGREHYWEFQDKEEFKRIKDNVMKKLNL
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
O58665
B0K532
CLPX_THEPX
ATP-dependent Clp protease ATP-binding subunit ClpX
unclassified Thermoanaerobacter
MVKYDNQKQLKCSFCGKTQDQVKRLVAGPGVYICDECIELCQEIINEEFEEDIDMGIGELPKPKEIKEFLDQYVIGQEKAKKALAVAVYNHYKRINSRIKPDDVELQKSNILLLGPTGSGKTLLAQTLAKLLNVPFAIADATSLTEAGYVGEDVENILLKLIQAADYDIEKAEKGIIYIDEIDKIARKSENPSITRDVSGEGVQQALLKILEGTIANVPPQGGRKHPHQEFIQIDTTNILFICGGAFEGIEKIIESRIGKKSLGFGAEVQSRKEKDLSEILSHIMPQDLLKFGMIPEFIGRVPIVVTLDPLSKDDLVRILTEPKNALTKQYEKLFELDGVKLEFDKKALGLIADMALERKTGARGLRAILEEIMLDVMYEIPSSDNIEKCIITEETVLKKAPPTLVYSDAQKAKKKIKKTESVS
ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
B0K532
O35796
C1QBP_RAT
Glycoprotein gC1qBP
Rattus
MLPLLRCVPRALGAAATGLRASIPAPPLRHLLQPAPRPCLRPFGLLSVRAGSARRSGLLQPPVPCACGCGALHTEGDKAFVEFLTDEIKEEKKIQKHKSLPKMSGDWELEVNGTEAKLLRKVAGEKITVTFNINNSIPPTFDGEEEPSQGQKAEEQEPELTSTPNFVVEVTKTDGKKTLVLDCHYPEDEIGHEDEAESDIFSIKEVSFQTTGDSEWRDTNYTLNTDSLDWALYDHLMDFLADRGVDNTFADELVELSTALEHQEYITFLEDLKSFVKSQ
Is believed to be a multifunctional and multicompartmental protein involved in inflammation and infection processes, ribosome biogenesis, protein synthesis in mitochondria, regulation of apoptosis, transcriptional regulation and pre-mRNA splicing. At the cell surface is thought to act as an endothelial receptor for plasma proteins of the complement and kallikrein-kinin cascades. Putative receptor for C1q; specifically binds to the globular 'heads' of C1q thus inhibiting C1; may perform the receptor function through a complex with C1qR/CD93. In complex with cytokeratin-1/KRT1 is a high affinity receptor for kininogen-1/HMWK. Can also bind other plasma proteins, such as coagulation factor XII leading to its autoactivation. May function to bind initially fluid kininogen-1 to the cell membrane. The secreted form may enhance both extrinsic and intrinsic coagulation pathways. It is postulated that the cell surface form requires docking with transmembrane proteins for downstream signaling which might be specific for a cell-type or response. By acting as C1q receptor is involved in chemotaxis of immature dendritic cells and neutrophils and is proposed to signal through CD209/DC-SIGN on immature dendritic cells, through integrin alpha-4/beta-1 during trophoblast invasion of the decidua, and through integrin beta-1 during endothelial cell adhesion and spreading. Signaling involved in inhibition of innate immune response is implicating the PI3K-AKT/PKB pathway. Required for protein synthesis in mitochondria. In mitochondrial translation may be involved in formation of functional 55S mitoribosomes; the function seems to involve its RNA-binding activity. May be involved in the nucleolar ribosome maturation process; the function may involve the exchange of FBL for RRP1 in the association with pre-ribosome particles. Involved in regulation of RNA splicing by inhibiting the RNA-binding capacity of SRSF1 and its phosphorylation. Is required for the nuclear translocation of splicing factor U2AF1L4. Involved in regulation of CDKN2A- and HRK-mediated apoptosis. May be involved in regulation of FOXC1 transcriptional activity and NFY/CCAAT-binding factor complex-mediated transcription. May play a role in antibacterial defense.
O35796
A5CT01
ISPG_CLAM3
1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase
Clavibacter
MPAVNLGMPKVPEVLAPRRKTRQISVGKVKVGGNAQVSVQSMTTTQTTNINATLQQIAELTATGCDIVRVAVPHQDDADVLHILAKKSQIPIIADIHFQPRYVFTAIDAGVGAVRVNPGNIRKFDDQVGAIAKAAKAAGVSIRIGVNAGSLHPSLLQKYGKATPEALVESAVWEASLFEEHDFHDFKISVKHNDPVIMVKAYRLLAERGDWPLHLGVTEAGPAFQGTIKSATAFGILLSEGIGDTIRVSLSAPPAEEVKVGLQILQSLNLRERKLEIVSCPSCGRAQVDVYSLAEQVTEGLKHVNVPLRVAVMGCVVNGPGEAREAELGVASGNGRGQIFVKGEVIKTVPEAEIVQTLIEEANRLAAEMPAGSIGSPEILV
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
A5CT01
Q9CDX5
RS14Z_LACLA
30S ribosomal protein S14 type Z
Lactococcus
MAKKSMVVKNQRPAKFSTQAYTRCERCGRPHSVYRKFKLCRICLRELAYKGQLPGVKKASW
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
Q9CDX5
Q9LLC1
BCCP2_ARATH
Biotin carboxyl carrier protein of acetyl-CoA carboxylase 2, chloroplastic
Arabidopsis
MASLSVPCVKICALNRRVGSLPGISTQRWQPQPNGISFPSDVSQNHSAFWRLRATTNEVVSNSTPMTNGGYMNGKAKTNVPEPAELSEFMAKVSGLLKLVDSKDIVELELKQLDCEIVIRKKEALQQAVPPAPVYHSMPPVMADFSMPPAQPVALPPSPTPTSTPATAKPTSAPSSSHPPLKSPMAGTFYRSPGPGEPPFVKVGDKVQKGQIVCIIEAMKLMNEIEAEKSGTIMELLAEDGKPVSVDTPLFVIAP
This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.
Q9LLC1
P72588
DNLJ_SYNY3
Polydeoxyribonucleotide synthase [NAD(+)]
unclassified Synechocystis
MTTPDRLLQLRQQLQKASYAYYVLDAPVMEDSVYDQLYRELQRLEAENPELITPDSPTQRVGEQPASQFRSVAHNIPLYSLENAFNVQELQQWQERWQRIAPTIEKAEYVCELKIDGSAIALTYENGLLVRGVTRGDGTTGEEISQNIKTIRSIPVKLNLDNPPPTVEVRGEAFLPLEEFNRINHEREAQGESLFANPRNAAAGTLRQLDPKIVHQRRLQFFAYTLHLPGQEDKIQSQWQALEYLKKAGFMVNPHCQLCKGLDEVVAYFEDWEGARQRLPYMTDGVVVKINQYPLQRELGFTQKFPRWAIALKYPAEETPTVVKAIEVNVGRTGAVTPLAVMEPVQLAGTTVQRATLHNQDRIQELDIRVGDTVIIRKAGEIIPEVVRVMTELRPENTTPYIFPSHCPACGSPLVRPLEEAVIRCVNSSCSAILQGSLIHWASRNALDIQGLGEKVVITLLENRLVNSVADLYGLQVEQLLGLERFAQKSAEKLIAAIEVSKSQPWSRILFGLGIRHVGQVNAKLLSQQFPTVEKLSQASIPDLEGVYGIGPEIAEAVVNWFRNPGNQQLIQDLEELGLVLANQGIDQTKTDSGKLKGKTFVLTGTLPNLSRLEAQELIEQSGGKVTSSVSTKTDYVLLGDKPGSKAAKAESLGIKLLSEAEFLQLLEP
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.
P72588
Q7V303
NDHK_PROMP
NDH-1 subunit K
Prochlorococcus
MNNSLSPKAIRELREETCNPLGAPQVTTDLSENIIMTSLDDLHNWARLSSLWPLLYGTACCFIEFAALIGSRFDFDRFGLVPRSSPRQADLLIVAGTVTMKMAPALVRLYEQMPEPKYVIAMGACTITGGMFSADSTTAVRGVDKLIPVDLYLPGCPPRPEAIFDAVIKLRKKVANESILERNKSEQTHRYLTVDHEMNLVFSENTGEYLNKKSEKSIESSKLNPVEESSENIYETNSIDEVIK
NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient. Cyanobacterial NDH-1 also plays a role in inorganic carbon-concentration.
Q7V303
P47620
RSMG_MYCGE
16S rRNA 7-methylguanosine methyltransferase
Mycoplasma
MNNANFEKYVDLVFEANKNFNLTGFKTKEAIYQNLVIEILTLFKGYEKFFIDKTVADLGSGNGSPGIILKLLFQKIKKLVLIDSKHKKISFLNKLTKQLNLEKTVAICERIEVHKNHYDVICSRGLSTIIKVNDLAFSLLNSKGIIFHIKQSLDQYIEFEKSNQKNQFNLLFIKHFTSQNKKLILIALQKND
Specifically methylates the N7 position of a guanine in 16S rRNA.
P47620
P0AA37
RLUA_ECOLI
tRNA pseudouridine(32) synthase
Escherichia
MGMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPADF
Dual specificity enzyme that catalyzes the synthesis of pseudouridine from uracil-746 in 23S ribosomal RNA and from uracil-32 in the anticodon stem and loop of transfer RNAs.
P0AA37