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We therefore wish to demonstrate that the protein and PUFA contents of the vitreous humour are different between eyes with retinal detachment and eyes not affected by retinal detachment after macular surgery (epiretinal membrane or macular hole). We would like to show that the vitreous PUFA content is lower in the macu... |
In addition, we hypothesise that retinal omega-3 PUFA content is a factor influencing retino-vitreal proliferation and functional and anatomical recovery from retinal detachment. To this end, we will study the correlation between retinal PUFA-3 content and the clinical presentation and postoperative course of retinal d... |
Finally, with the aim of identifying a serum marker for the prognostic evaluation of retinal detachment, we will use as a candidate a biomarker of retinal omega-3 PUFA content that we have developed in an Age-Related Macular Degeneration (AMD) model. We will analyse the correlation between this biomarker and levels of ... |
To do this, we will analyse intraoperative samples of vitreous humour, sub-retinal fluid and retinal fluid from patients undergoing vitrectomy for retinal detachment in the Ophthalmology Department of the Dijon University Hospital. A group of control patients will consist of patients operated on by vitrectomy for macul... |
Clinical information on the characteristics of the retinal detachment will be collected. During the consultation, the patient will be questioned about any history of dyslipidaemia and any current treatment, including the use of lipid-enriched food supplements. Post-operative follow-up with prospective collection of cli... |
A blood sample will be taken to establish a lipid profile in all patients. We will thus gain a better understanding of the changes in lipid and protein content in the vitreous humour, sub-retinal fluid and retina, and the demonstration of a link between the initial presentation and the postoperative anatomical and func... |
<|newrecord|> nctId: NCT06347289 id: CHSD_0024_REA briefTitle: Refusal of Organ Donation: a Study of Psychological, Anthropological and Cultural Factors overallStatus: COMPLETED date: 2022-01-01 date: 2023-04-30 date: 2024-03-29 date: 2024-04-04 date: 2024-04-04 name: Centre Hospitalier de Saint-Denis class: OTHER name... |
Based on hypotheses derived from psychological and anthropological perspectives, this survey will provide first-hand information on the personal, family and cultural issues related to organ donation. It will be a question of identifying and locating individual and collective representations concerning death, its defini... |
<|newrecord|> nctId: NCT06347276 id: 2023-RW320-08 briefTitle: Cerebral Microembolization Associated With PFO Closure overallStatus: RECRUITING date: 2024-01-01 date: 2024-12-31 date: 2024-12-31 date: 2024-04-04 date: 2024-04-04 name: China National Center for Cardiovascular Diseases class: OTHER_GOV briefSummary: This... |
<|newrecord|> nctId: NCT06347263 id: PER 332 briefTitle: Clinical and Radiographic Evaluation of Using the Entire Papilla Preservation Technique With and Without Autogenous Bone Graft and Injectable Platelet Rich Fibrin in Treatment of Periodontal Intraosseous Defects overallStatus: RECRUITING date: 2024-04 date: 2025-... |
- Outcome assessor (primary and secondary outcomes) \& biostatistician will be blinded whoMasked: OUTCOMES_ASSESSOR count: 24 type: ESTIMATED name: Entire papilla preservation technique measure: Clinical attachment level (CAL) gain change from baseline to 12 months measure: Linear bone fill change from baseline to 12 m... |
<|newrecord|> nctId: NCT06347250 id: SGB-Bulbar Palsy briefTitle: A Nerve Block Therapy for Bulbar Palsy Pharyngeal Dysphagia overallStatus: COMPLETED date: 2022-01-01 date: 2023-05-02 date: 2023-05-31 date: 2024-04-04 date: 2024-04-04 name: Babujinaya Cela class: OTHER_GOV briefSummary: This was a multicenter randomiz... |
<|newrecord|> nctId: NCT06347237 id: NL84429.078.23 briefTitle: PsA Digital Phenotyping and Inflammation Drivers Study acronym: PDPID overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2025-12 date: 2025-12 date: 2024-04-04 date: 2024-04-04 name: Jolanda Luime class: OTHER name: University of Oxford - Nuffield Depar... |
* In patients with psoriatic arthritis, is a digital biomarker capable of detecting a flare as compared to clinical defined flare by the rheumatologist? |
* In patients with psoriatic arthritis, what factors trigger a psoriatic arthritis flare ? |
Participants will be requested to: |
* Install app on their phone |
* Use a smartwatch |
* Complete questionnaires |
* Collect biological material conditions: Psoriatic Arthritis conditions: Flare Up, Symptom conditions: Psoriatic Arthritis Aggravated studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 600 type: ESTIMATED measure: Absence of flare in patients measure: Minimal disease Activity (MDA)... |
<|newrecord|> nctId: NCT06347224 id: BCFC-BCS-VIRTUAL2024 briefTitle: Both Column Fixation Corridor in Pelvic Surgery overallStatus: COMPLETED date: 2023-10-01 date: 2024-02-01 date: 2024-03-01 date: 2024-04-04 date: 2024-04-04 name: Bakirkoy Dr. Sadi Konuk Research and Training Hospital class: OTHER_GOV briefSummary: ... |
<|newrecord|> nctId: NCT06347211 id: Attikon Hospital briefTitle: "Hypotension Probability Indicator" in TAVI/MitraClip for Hypotension Management overallStatus: RECRUITING date: 2024-01-10 date: 2026-01-10 date: 2026-01-10 date: 2024-04-04 date: 2024-04-05 name: Attikon Hospital class: OTHER briefSummary: The study wi... |
<|newrecord|> nctId: NCT06347198 id: 20230807-02 briefTitle: Oral Inulin in Combination With Fruquintinib Plus Sintilimab as Third- or Further-line Treatment in Metastatic Colorectal Cancer overallStatus: RECRUITING date: 2024-04-10 date: 2024-12-01 date: 2025-05-01 date: 2024-04-04 date: 2024-04-04 name: Wuhan Union H... |
<|newrecord|> nctId: NCT06347185 id: EORTC-2236-HNCG-QLG briefTitle: Simultaneous Care in Recurrent and/or Metastatic Head and Neck Cancer: the SupCare Study acronym: SupCare overallStatus: NOT_YET_RECRUITING date: 2024-09 date: 2027-04 date: 2028-12 date: 2024-04-04 date: 2024-04-04 name: European Organisation for Res... |
The study randomizes patients in a 1:1 fashion to standard oncologic care, in which the palliative care is requested as needed (reactive approach) or to early palliative care integrated with the standard oncologic care (proactive approach). |
Standard of Care: the oncologist will be the main referral of the patient, deciding the therapeutic approach, the assessments requested, in terms of type of exams and timing and the need of possible further support from other expertise. The oncologist will base the choices also upon the results of the Liverpool Head an... |
Integrated approach: Besides the Oncology visit, patient will have the palliative care expert visit and follow up. The oncologist will define the therapeutic approach and the assessments requested, in terms of type of exams and timing. The palliative care clinician and the oncologist will judge the burden of symptoms a... |
Stratification Factors |
* Institution |
* Performance Status (PS) (0 vs 1-2) |
* Presence of any caregiver at home |
* Type of treatment (Immunotherapy alone vs any other combination) |
Study duration: the total study duration is estimated at 36 months, with a total accrual time estimated to be 24 months from first patient in (FPI) and with an additional follow-up period of 12 months. |
End of study occurs when all patients have completed their end of study visit and the study is mature for all analyses defined in the protocol and the database has been cleaned and frozen for these analyses. conditions: Head and Neck Neoplasms studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionMode... |
<|newrecord|> nctId: NCT06347172 id: 2024p000278 id: U54AG063546 type: NIH link: https://reporter.nih.gov/quickSearch/U54AG063546 briefTitle: Deprescribing in Patients Living With Dementia With Caregiver and Provider Nudges overallStatus: NOT_YET_RECRUITING date: 2024-05-15 date: 2024-11-15 date: 2025-01-15 date: 2024-... |
<|newrecord|> nctId: NCT06347159 id: EDG-7500-102 briefTitle: A Study of EDG-7500 in Adult Patients With Obstructive Hypertrophic Cardiomyopathy (CIRRUS-HCM) overallStatus: RECRUITING date: 2024-04 date: 2025-03 date: 2025-03 date: 2024-04-04 date: 2024-04-04 name: Edgewise Therapeutics, Inc. class: INDUSTRY briefSumma... |
<|newrecord|> nctId: NCT06347146 id: R01HD112323 type: NIH link: https://reporter.nih.gov/quickSearch/R01HD112323 id: R01HD112323 type: NIH link: https://reporter.nih.gov/quickSearch/R01HD112323 briefTitle: Bridges2Scale: Testing Implementation Strategies overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2028-03... |
Aim 2. Determine the clinical effectiveness of Bridges implemented via a standard vs. enhanced implementation strategy. Aim 3: Explore implementation processes, mechanisms, and determinants. Aim 4. Compare the cost and cost-effectiveness of the two implementation strategies. Using an activity-based ingredients approach... |
<|newrecord|> nctId: NCT06347133 id: AROAPOC3-3009 id: 2023-509302-30 type: EUDRACT_NUMBER briefTitle: Phase 3 Study of Plozasiran in Adults With Hypertriglyceridemia acronym: MUIR-3 overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2026-07 date: 2026-10 date: 2024-04-04 date: 2024-04-04 name: Arrowhead Pharmaceuti... |
<|newrecord|> nctId: NCT06347120 id: PI2024_843_0011 briefTitle: Place of Nasogastric Tube in Uncomplicated Adhesive Small Bowel Obstruction acronym: BOWNTI overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2027-03 date: 2027-04 date: 2024-04-04 date: 2024-04-18 name: Centre Hospitalier Universitaire, Amiens class:... |
The working group on ASBO of the World Society of Emergency Surgery suggested two distinct approaches for the management of acute ASBO: non-operative management (NOM) which concerning around 85% of patients and operative management (OM) : |
* OM: if there is clinical signs of strangulation, peritonitis, bowel ischemia, or if IV CT Scan shows sign of ischemia, strangulation, peritonitis, or if the occlusion persists for more than 72 hours; |
* NOM in all other cases, including nasogastric tube (NGT), intravenous administration of fluids, and clinical and biochemical monitoring for 72h. |
NGT is an old concept first describe for treatment of ASBO based on several studies made on the dog where he proved efficacy of NGT by aspirating gas in the stomach favorising venous decompression and survival of patients. Since, NGT became one of the pillars of NOM. |
However NGT is quite bad tolerated by patients (ranked the most painful hospital procedure), some of them refuse it, others put off after the beginning of the treatment and one of the most frequent complications of NGT is pneumonia, which is quite surprising when the first argument for its insertion is to avoid inhalat... |
Four specific retrospectives studies showed that absence of NGT is possible in 20 to 80% of included patients and was associated with a decrease: in transit recovery time; in complications rate (including rates of pneumonia); in length of stay (LOS); without an increased risk of surgery or resection. 20-87% (a total of... |
To summarize, the investigators therefore know that the insertion of a NGT is painful, does not relieve all patients, and has an unquantified therapeutic effect on the evolution of ASBO. That is why it is pertinent, in 2023, to question the useless of NGT in the treatment of ASBO, in selected patients. This study would... |
<|newrecord|> nctId: NCT06347107 id: S67215 briefTitle: Robotic Subretinal tPA Injection Study acronym: RoTIS overallStatus: RECRUITING date: 2024-04 date: 2025-12 date: 2025-12 date: 2024-04-04 date: 2024-04-04 name: Universitaire Ziekenhuizen KU Leuven class: OTHER name: DORC Dutch Ophthalmic Research Center Internat... |
* The robotic stabilizer (prototype - FAMHP approval received) |
* 41G subretinal needle (CE marked - used within label) |
* Inicio micro-injection system (CE marked - used within label) The Inicio system mounted with the 41G needle will be held by the robot, and guided by the surgeon towards the required position. When the tip of the needle is in the desired subretinal position, the robotic stabilizer will be locked and the tPA will be in... |
As performed routinely, the surgical view through the microscope will be video-recorded and while the injection is being administered, the built-in iOCT of the Artevo surgical microscope (Zeiss, Oberkochen, Germany) will be used to scan the retina area around the injection site to record the subretinal bleb formation f... |
<|newrecord|> nctId: NCT06347094 id: 610/2023/SPER/UNIPR briefTitle: Precision Nutrition to Improve Cardiometabolic Health With Dietary (Poly)Phenols acronym: PRE-CARE-DIET overallStatus: NOT_YET_RECRUITING date: 2024-04-11 date: 2025-12-31 date: 2025-12-31 date: 2024-04-04 date: 2024-04-04 name: University of Parma cl... |
<|newrecord|> nctId: NCT06347081 id: P.T.REC/012/00449 briefTitle: Effect of Nd-YAG Laser on Hypertrophic Scar acronym: Nd-YAG overallStatus: COMPLETED date: 2022-05-01 date: 2024-02-28 date: 2024-02-28 date: 2024-04-04 date: 2024-04-04 name: Cairo University class: OTHER briefSummary: A hypertrophic scar is a serious ... |
T test for comparison before-treatment between the control and study groups. ANOVA with repeated measures test for comparison among other measures. conditions: Hypertrophic Scar studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: one treatment one contro... |
<|newrecord|> nctId: NCT06347068 id: LCCC2128-ATL briefTitle: Study of Autologous CAR-T Cells Targeting B7-H3 in TNBC iC9-CAR.B7-H3 T Cells overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2026-05 date: 2028-05 date: 2024-04-04 date: 2024-04-23 name: UNC Lineberger Comprehensive Cancer Center class: OTHER name: Be... |
<|newrecord|> nctId: NCT06347055 id: 403690 briefTitle: NeuroControl of Nicotine Dependence overallStatus: NOT_YET_RECRUITING date: 2024-04-15 date: 2030-03-25 date: 2030-04-30 date: 2024-04-04 date: 2024-04-08 name: University of Missouri-Columbia class: OTHER briefSummary: The purpose of the study is to examine the e... |
<|newrecord|> nctId: NCT06347042 id: 012/004897 briefTitle: Effect of Qigong on Sleep Quality in Fibromyalgia overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2024-06 date: 2024-06 date: 2024-04-04 date: 2024-04-04 name: Cairo University class: OTHER briefSummary: This study aims to determine any significant effic... |
<|newrecord|> nctId: NCT06347029 id: Endothelial dysfunction briefTitle: Evaluation of Endothelial Dysfunction Using the "Flow Mediated Dilation" Test in a Population of Chronic Renal Failure Patients at Different Stages, and Evaluation of the Role of Antiphospholipid Antibodies overallStatus: RECRUITING date: 2023-10-... |
For HD to be effective, it is essential that the blood flow rate passing through the dialyzer is greater than 300ml/min. This imperative requires that any hemodialysis patient have specific vascular access (dialysis catheter or arteriovenous fistula (AVF)) to ensure these flow rates. The vascular access of choice is th... |
Complications of arteriovenous fistula are common. Arteriovenous fistula maturation may be delayed (maturation delay) or even absent. Drainage veins and/or anastomoses can also be the site of stenosis or thrombosis. The pathophysiology of these complications is complex and multifactorial. Among the risk factors for the... |
Antiphospholipid syndrome (APS) is an autoimmune disease causing a thrombotic phenotype. This is an acquired thrombophilia. In the general population, the prevalence of antiphospholipid antibodies is around 0.5%; this prevalence is far from rare in hemodialysis, since it represents up to 37% in dialysis patients. In a ... |
Interestingly, a third of the cohort presented an antibody profile that did not allow them to be classified according to the classification criteria in force. This group corresponds to patients with a single positive dosage, either not recontrolled or recontrolled negative. This group was called Fluctuating. This fluct... |
Endothelial dysfunction is also implicated in the pathophysiology of APS. In clinical practice, the "flow mediated dilation" (FMD) test makes it possible to assess endothelial dysfunction in vivo. It involves the phenomenon of post-occlusive hyperemia which is mainly linked to NO and endothelium-dependent vasodilation.... |
The objective of this study is to evaluate the weight of antiphospholipid biology on endothelial dysfunction in hemodialysis patients, using the FMD test. |
1. Compare endothelial dysfunction by FMD according to the stage of chronic kidney disease and in comparison to a control group without chronic kidney disease. |
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