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The application of radiomics to preoperative ultrasound images could identify BRCA mutated tumors before surgical planning (radiogenomic analysis) and allow a personalized treatment. |
The aim of the study is to validate a predictive model to define the risk of malignancy of adnexal masses that the investigators developed at the Fondazione IRCCS Istituto Nazionale dei Tumori di Milano. |
The model, based on the integration of radiomics and artificial intelligence, uses complex software capable of 'reading' the ultrasound images in a completely automatic way and is able to estimate the risk of malignancy of the mass. |
If the patient decide to participate in the clinical study, the patient will undergo transvaginal ultrasound (eventually supplemented by transabdominal ultrasound in case of large adnexal masses, if the patients are virgo or if the patients will refuse transvaginal approach for any reason). This exam is part of the rou... |
Thereafter, the images stored during the preoperative ultrasound will be exported in anonymous format from the ultrasound system, and sent to the coordinating center (Fondazione IRCCS Istituto Nazionale dei Tumori di Milano). There, images will be submet to radiomic analysis through the application of a dedicated softw... |
This analysis, once validated, will provide clinicians an additional tool to identify malignant adnexal masses prior to surgery. |
If the final histological diagnosis is of serous epithelial ovarian cancer, through the use of the same radiomics software described above the investigators will try to identify the intrinsic characteristics of the tissue associated with the presence or absence of the BRCA 1 or 2 mutation conditions: Ovarian Cysts cond... |
<|newrecord|> nctId: NCT06342921 id: ADC189-2022-01 briefTitle: ADC189 Tablets on Influenza A Virus Infection/Influenza B Virus Infection acronym: ADC overallStatus: RECRUITING date: 2022-12-07 date: 2024-06-30 date: 2024-06-30 date: 2024-04-02 date: 2024-04-02 name: Jiaxing AnDiCon Biotech Co.,Ltd class: INDUSTRY brie... |
The main aim to answer: |
* Phase II study is to evaluate the efficacy of ADC189 tablets in the treatment of adult influenza subjects and determine the optimal therapeutic dose by analyzing the time of virus titer turning to negative. All the results will be used to design the Phase III study. |
* Phase III study is to evaluate the efficacy of ADC189 tablets by analyzing the duration of remission of all influenza symptoms in adolescents and adults subjects with influenza. |
Participants will be taken ADC189 teblets/Placebo once, and be observed by 22 days. |
Phase II study has 3 groups: 15 mg ADC189; 45 mg ADC189; and Placebo; Phase III study has 2 groups: 45 mg ADC189; and Placebo. conditions: Safety Issues conditions: Effect of Drug studyType: INTERVENTIONAL phases: PHASE2 phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking... |
<|newrecord|> nctId: NCT06342908 id: 23-001700 id: NCI-2024-00210 type: REGISTRY domain: CTRP (Clinical Trial Reporting Program) briefTitle: A Vaccine (Neoantigen-Targeted ppDC) for the Treatment of H3 G34-mutant Diffuse Hemispheric Glioma overallStatus: NOT_YET_RECRUITING date: 2024-05-08 date: 2027-03-08 date: 2028-0... |
<|newrecord|> nctId: NCT06342895 id: 2020_1113 id: 2022-A00103-40 type: OTHER domain: ID-RCB number, ANSM briefTitle: Interpretation and Optimization of Nutrition in the Intensive Care Units acronym: IONIC overallStatus: RECRUITING date: 2024-04-10 date: 2025-04 date: 2025-09 date: 2024-04-02 date: 2024-04-25 name: Dim... |
Furthermore, this discrepancy between prescribed and delivered nutrition may go largely unnoticed, due to issues concerning inadequate manual or automated monitoring of delivered nutrition. A joint "Call to Action" by ASPEN, the Academy of Nutrition and Dietetics, and the American Society of Health-System Pharmacists s... |
Nutrow® is a software package designed to support nutritional management based on the calculation of recommended calorie and protein requirements, real-time calculation and monitoring of calorie and protein prescriptions, real-time calculation and monitoring of calories and protein truly delivered to patients, and info... |
The aim of the study is to assess whether the joint use of Nutrow-Feedim improves the achievement of nutritional objectives in ICU patients prior to oral intake by reducing the discrepancy between prescribed and delivered calories and protein. conditions: Nutritional Support studyType: INTERVENTIONAL phases: NA allocat... |
<|newrecord|> nctId: NCT06342882 id: GO 19/833- A briefTitle: Dysphagia Severity and Functional Independence Level overallStatus: COMPLETED date: 2020-01-01 date: 2024-01-01 date: 2024-02-01 date: 2024-04-02 date: 2024-04-02 name: Atılım University class: OTHER briefSummary: Functional independence is the ability of a ... |
Dysphagia can be seen in more than 50% of neurological patients, and it is called neurogenic dysphagia. Muscle weakness, tonus changes, sensory loss and coordination problems occur in these patients. Pain and fatigue are also frequently observe. These patients have problems with fine and gross motor movements, and ther... |
Dysphagia-induced malnutrition adversely affects many systems, including the musculoskeletal system. In a study conducted in the elderly with dysphagia, atrophy in the total muscle mass and swallowing muscles, and increase in intramuscular adipose tissue were reported as a result of malnutrition. Decreases in the muscl... |
<|newrecord|> nctId: NCT06342869 id: 690 briefTitle: Comparison of the Effects of Lidocaine and Articaine Used for Buccal Infiltration and Supplemental Palatinal Infiltration Anesthesia in Teeth With Irreversible Pulpitis overallStatus: COMPLETED date: 2022-04-01 date: 2022-10-01 date: 2022-12-01 date: 2024-04-02 date:... |
Method: Among the patients who applied to Akdeniz University Faculty of Dentistry Endodontic Clinic for the treatment of maxillary molars with irreversible pulpitis, 80 volunteers who met the criteria were included in the study. Eighty patients were divided into 4 groups (n = 20). 1. group buccal infiltration with 4% a... |
<|newrecord|> nctId: NCT06342856 id: idiopathic infertility briefTitle: Evaluation of Treatment With Coenzyme Q10 and L-Carnitine on Semen Parameters in Infertile Men With Idiopathic Oligoasthenoteratospermia acronym: infertility overallStatus: RECRUITING date: 2023-06-15 date: 2024-06-01 date: 2024-07-01 date: 2024-04... |
<|newrecord|> nctId: NCT06342843 id: SPLAsH id: NL81395.075.22 type: OTHER domain: CCMO briefTitle: Direct Superior Approach Versus PosteroLateral Approach in Total Hip Arthroplasty (SPLAsH) acronym: SPLAsH overallStatus: RECRUITING date: 2024-02-13 date: 2026-08-30 date: 2026-11-30 date: 2024-04-02 date: 2024-04-02 na... |
<|newrecord|> nctId: NCT06342830 id: End 20-05 P briefTitle: Comparing the Effect of Different Intracanal Dressing on Failed Root Canal Treated Cases on Periapical Healing overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2024-12 date: 2025-05 date: 2024-04-02 date: 2024-04-08 name: Ain Shams University class: OTHE... |
* Is natural and synthetic intracanal Medicament effective in reducing or complete healing of Periapical lesions or not? the researchers will compare the effect of different intracanal dressing including: |
* nanocurcumin gel |
* curcumin gel |
* ciprofloxacin +ibuprofen gel |
* calcium hydroxide Paste as control group in between the endodontic retreatment visits to see if these medicaments work well on periapical lesion healing this outcome measured by Cone beam CT at base and after 6 months follow up periods conditions: Periapical Disease studyType: INTERVENTIONAL phases: PHASE2 allocation... |
<|newrecord|> nctId: NCT06342817 id: UFFS briefTitle: Effects of Meditation on Sleep Quality of Medical Students overallStatus: RECRUITING date: 2023-10-18 date: 2024-06-30 date: 2024-06-30 date: 2024-04-02 date: 2024-04-02 name: Universidade Federal da Fronteira Sul class: OTHER briefSummary: The objective of the stud... |
<|newrecord|> nctId: NCT06342804 id: GIB-01-02-2023 briefTitle: Food Effect on the Bioavailability of 4-MUST, Tablets, 128 mg overallStatus: RECRUITING date: 2024-03-19 date: 2024-12-31 date: 2024-12-31 date: 2024-04-02 date: 2024-04-02 name: Valenta Pharm JSC class: INDUSTRY briefSummary: Primary objective of the stud... |
Additional aim of the study: evaluation of pharmacokinetic parameters, safety and tolerability of 4-MUST, tablets, 128 mg (Valenta Pharm JSC) in healthy volunteers after a single oral administration on an empty stomach and after a meal, at a dose of 256 mg (two tablets). conditions: Cholecystitis studyType: INTERVENTIO... |
<|newrecord|> nctId: NCT06342791 id: 004349 briefTitle: Effect of Laser Acupuncture on Menstrual Back Pain overallStatus: RECRUITING date: 2024-02-20 date: 2024-05-20 date: 2024-06-20 date: 2024-04-02 date: 2024-04-02 name: Cairo University class: OTHER briefSummary: effect of laser acupuncture on menstrual back pain c... |
<|newrecord|> nctId: NCT06342778 id: DIP-05-02-2023 briefTitle: Pharmacokinetics and Bioequivalence of Doxylamine+Pyridoxine and Diclectin overallStatus: RECRUITING date: 2024-02-27 date: 2024-12-31 date: 2024-12-31 date: 2024-04-02 date: 2024-04-02 name: Valenta Pharm JSC class: INDUSTRY briefSummary: Comparative stud... |
<|newrecord|> nctId: NCT06342765 id: SV009 briefTitle: Safety and Performance of the SpineVision Posterior Fixation Systems in Thoracolumbar Spinal Treatment acronym: FixedD3 overallStatus: RECRUITING date: 2022-09-22 date: 2028-05-30 date: 2028-05-30 date: 2024-04-02 date: 2024-04-03 name: SpineVision class: INDUSTRY ... |
Part of their standard of care, participants will be questioned on their back and leg pains, their disability and if they have encountered any adverse effects since the Spinevision posterior fixation system implant surgery. Those data will be collected up to twenty four (24) months after the Spinevision posterior fixat... |
<|newrecord|> nctId: NCT06342752 id: 6007 briefTitle: The Role of VOCs, Airway Mucins and Airway Microbiome in Bronchopulmonary Dysplasia acronym: INFANCY overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2026-09 date: 2027-09 date: 2024-04-02 date: 2024-04-02 name: University Hospital, Antwerp class: OTHER briefSu... |
Despite the well-established primordial role of inflammation and oxidative stress in the development of BPD, clinical practice does not incorporate the testing for biomarkers associated with the development of BPD. The diagnosis of BPD based on required respiratory support at 36 weeks PML, stresses the need for an earl... |
Secondly, mucin expression aim to play a rol in other respiratory diseases, whereas in BPD only the potential role of MUC1 was explored. |
Thirdly, the composition of the airway microbial composition of an infant is assumed to be influenced by different factors. From early on in pregnancy the airway microbiome of the infant is formed, offering a protective role against pathologies. On the other hand, the role of the airway microbiome in the development of... |
The threefold aim of this study is as follows: |
I. The development of a non-invasive breath test that allows early detection of bronchopulmonary dysplasia, using the potential of VOCs in exhaled breath as biomarkers for inflammation and oxidative stress. |
II. The exploration of the composition and diversity of the airway microbiome in infants with BPD, their association with exhaled VOCs and the exploration of the placental and vaginal microbiome. |
III. The detection of potential alterations in airway mucin expression in BPD patients. |
Through this comprehensive approach, we seek to gain a deeper understanding of how these mutual associations may contribute to the later development of BPD. |
In total 140 preterm infants, including 70 BPD patients and 70 preterm controls, born below 30 weeks' gestation at the Antwerp University Hospital will be included. conditions: Bronchopulmonary Dysplasia studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 140 type: ESTIMATED name: Br... |
<|newrecord|> nctId: NCT06342739 id: IEO 1595 briefTitle: Verbal Synchrony, Satisfaction and Decision-making in Face-to-face Consultations overallStatus: RECRUITING date: 2022-03-23 date: 2024-12-31 date: 2024-12-31 date: 2024-04-02 date: 2024-04-02 name: European Institute of Oncology class: OTHER briefSummary: Eligib... |
<|newrecord|> nctId: NCT06342726 id: 2024/714469 briefTitle: The Effect of Active External Rewarming on Rewarming Rate in Simulated Prehospital Accidental Hypothermia overallStatus: RECRUITING date: 2024-05-28 date: 2024-06-02 date: 2024-06-02 date: 2024-04-02 date: 2024-04-02 name: Haukeland University Hospital class:... |
The participants will be cooled to a core temperature of 35 degress C, the rewarmed using 2 different scenarios. Scenario 1 will be with passive rewarming, scenario 2 with active rewarming. Shivering will be pharmacologically inhibited using Buspirone and Meperidine. conditions: Accidental Hypothermia studyType: INTERV... |
Before the start of experiment, the research participant will be cooled in an ice cave wearing wet clothing and with 2-3 m/s wind to a core temperature of 35.0 °C using the established protocol for inhibition of shivering. The maximum cooling time will be 2 hours (120 minutes). The order of interventions will be random... |
When the research subjects reach the target temperature of 35.0°C or the maximum cooling time of 2 hours, they will be subjected to one of the two scenarios listed below, with a rewarming phase of maximum 60 minutes. primaryPurpose: TREATMENT masking: TRIPLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR whoMasked: OUT... |
<|newrecord|> nctId: NCT06342713 id: BGB-45035-101 briefTitle: A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single- and Multiple-Ascending Doses and Food Effect of BGB-45035 overallStatus: NOT_YET_RECRUITING date: 2024-05-28 date: 2025-04-30 date: 2025-04-30 date: 2024-04-02 d... |
Study details include: |
* The study duration will be up to 16 months. |
* The treatment duration will be up to 14 days. |
* Safety follow-up 30 days after last dose of study drug. conditions: Healthy Participants conditions: Healthy Subjects conditions: Healthy Volunteers conditions: Autoimmune Diseases conditions: Healthy Adult Participants studyType: INTERVENTIONAL phases: PHASE1 allocation: RANDOMIZED interventionModel: PARALLEL primar... |
<|newrecord|> nctId: NCT06342700 id: PKM18138 id: U1111-1299-1906 type: REGISTRY domain: ICTRP briefTitle: A Food Effect and Relative Bioavailability Study of Rilzabrutinib in Healthy Participants overallStatus: RECRUITING date: 2024-03-25 date: 2024-04-29 date: 2024-04-29 date: 2024-04-02 date: 2024-04-11 name: Sanofi... |
The total study duration per participant is expected to be up to 36 days, including: |
* Screening: up to 4 weeks |
* Treatment periods: once successfully screened, enrolled participants will be randomized to 1 of 4 treatment sequences with 4 single dose treatment periods. |
* Washout: One day washout is planned after each treatment period hence providing 2 days between doses. |
* Safety follow-up: participants will be asked to participate in an end-of-study safety assessment upon discharge from the clinical study unit, ie, on Day 8 of the study. conditions: Autoimmune Disorder conditions: Healthy Volunteers studyType: INTERVENTIONAL phases: PHASE1 allocation: RANDOMIZED interventionModel: CRO... |
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