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This study is expected to include a total of approximately 17-42 participants. conditions: Advanced Solid Tumors studyType: INTERVENTIONAL phases: PHASE1 allocation: NA interventionModel: SEQUENTIAL primaryPurpose: TREATMENT masking: NONE count: 17 type: ESTIMATED name: KH801 measure: MTD measure: DLT measure: RP2D mea... |
<|newrecord|> nctId: NCT06364488 id: 295721 briefTitle: TrueBlue Clinical Study - Investigating the Use of a Mobile Phone App TrueBlue for Monitoring Depression and Anxiety overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2024-10-31 date: 2025-07-31 date: 2024-04-15 date: 2024-04-15 name: BlueSkeye AI class: IN... |
<|newrecord|> nctId: NCT06364475 id: BezmialemVU-TF-AÖ-1 briefTitle: Could a Time-restricted Diet Compete With a Calorie-restricted 6-meal Diet? overallStatus: COMPLETED date: 2021-11-01 date: 2022-07-01 date: 2022-09-01 date: 2024-04-15 date: 2024-04-15 name: Bezmialem Vakif University class: OTHER briefSummary: The p... |
<|newrecord|> nctId: NCT06364462 id: ZLRK202301 briefTitle: Precise Evaluation Criteria for Histological Regression of NASH Fibrosis overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2027-03-09 date: 2027-04-01 date: 2024-04-15 date: 2024-04-15 name: Beijing Friendship Hospital class: OTHER briefSummary: It is a... |
<|newrecord|> nctId: NCT06364449 id: 202309052RIND briefTitle: Clinical Decision Tree Analysis of Hemodialysis Arteriovenous Access Choices and Creations - a Multiple-center Retrospective Cohort Study overallStatus: RECRUITING date: 2023-10-13 date: 2024-05-07 date: 2024-05-31 date: 2024-04-15 date: 2024-04-15 name: Na... |
<|newrecord|> nctId: NCT06364436 id: AksarayU1 briefTitle: Distant Reiki Therapy on Postpartum Period Fatigue and Depression overallStatus: ACTIVE_NOT_RECRUITING date: 2022-06-03 date: 2024-03-18 date: 2024-04-10 date: 2024-04-15 date: 2024-04-15 name: Aksaray University class: OTHER briefSummary: This research was con... |
<|newrecord|> nctId: NCT06364423 id: 10001599 id: 001599-C briefTitle: Anti-CD19 Chimeric Antigen Receptor T-Cell Immunotherapy for Chronic Lymphocytic Leukemia (CLL) overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2029-07-01 date: 2030-07-01 date: 2024-04-15 date: 2024-04-26 name: National Cancer Institute (N... |
Chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL) are blood cancers that affect certain white blood cells. Advanced forms of these diseases are difficult to treat. CD19 is a protein often found on the surfaces of these cancer cells. Researchers can modify a person's own immune cells (T cells) to t... |
Objective: |
To test anti-CD19 CAR T cell therapy in people with CLL or SLL. |
Eligibility: |
People aged 18 years and older with CLL or SLL that has not been controlled with standard drugs. |
Design: |
Participants will be screened. They will have imaging scans and tests of their heart function. If a sample of tissue from their tumor is not available, a new one may be taken; the sample will be tested for CD19. |
Participants will receive a drug to reduce the leukemia cells in their blood. Then they will undergo apheresis: Blood will be taken from the body through a needle. The blood will pass through a machine that separates out the T cells. The remaining blood will be returned to the body through a different needle. The colle... |
Participants will take drugs to prepare them for treatment for 3 days. These drugs will start 5 days before the treatment. Then their own modified CAR T cells will be returned to their bloodstream. Participants will stay in the hospital for at least 9 days after the treatment. |
Follow-up visits will continue for 5 years. conditions: B-Cell Chronic Lymphocytic Leukemia conditions: Leukemia, Lymphocytic, Chronic, B-Cell conditions: B-Lymphocytic Leukemia, Chronic studyType: INTERVENTIONAL phases: PHASE1 phases: PHASE2 allocation: NON_RANDOMIZED interventionModel: SEQUENTIAL primaryPurpose: TREA... |
<|newrecord|> nctId: NCT06364410 id: NCI-2024-02982 id: NCI-2024-02982 type: REGISTRY domain: CTRP (Clinical Trial Reporting Program) id: 10554 type: OTHER domain: University of Texas MD Anderson Cancer Center LAO id: 10554 type: OTHER domain: CTEP id: UM1CA186688 type: NIH link: https://reporter.nih.gov/quickSearch/UM... |
<|newrecord|> nctId: NCT06364397 id: ESPRIT202403 briefTitle: Efficacy of ERCP in the Diagnosis and Treatment of Idiopathic Recurrent Acute Pancreatitis acronym: ESPRIT overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2026-03 date: 2026-05 date: 2024-04-15 date: 2024-04-18 name: Changhai Hospital class: OTHER name... |
Does ERCP reduce the frequency of pancreatitis episodes in IRAP patients? Does ERCP contribute to identify the etiology of IRAP patients? |
Participants will be randomly allocated to receive ERCP (pancreatic sphincterotomy and pancreatic stent placement) or conservative treatment and be followed for 1 year. conditions: Recurrent Acute Pancreatitis studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATM... |
<|newrecord|> nctId: NCT06364384 id: E2024074 briefTitle: Radical Synchronous Chemoradiotherapy With DDP/5-FU and PD-1 for Non-metastatic Rectal Squamous Cell Carcinoma overallStatus: RECRUITING date: 2024-04-20 date: 2024-04-20 date: 2027-02-28 date: 2024-04-15 date: 2024-04-15 name: Sixth Affiliated Hospital, Sun Yat... |
Does PD-1 monoclonal antibody combined with radical chemoradiotherapy improve survival prognosis? What is the complete response rate (CCR) of the regime？ Researchers will compare PD-1 monoclonal antibody combined with radical chemoradiotherapy to previous study to see if this regime works to treat rSCCs. |
Participants will receive chemotherapy with DDP and 5-FU, immunotherapy with PD-1 monoclonal antibody and radiotherapy with a total dose of 50-54GY. conditions: Rectal Squamous Cell Carcinoma studyType: INTERVENTIONAL phases: PHASE2 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE ... |
<|newrecord|> nctId: NCT06364371 id: E2023210 briefTitle: Dynamic Multi-omics Integration Model to Predict Neoadjuvant Therapy Response in Locally Advanced Rectal Cancer overallStatus: RECRUITING date: 2024-05-01 date: 2025-06-01 date: 2026-06-01 date: 2024-04-15 date: 2024-04-15 name: Sixth Affiliated Hospital, Sun Ya... |
What is the predictive value of this model to assess individual achievement of pathological complete response (pCR) after neoadjuvant treatment? Eligible patients will be prospectively enrolled, and the clinical features of their pre-neoadjuvant treatment, during-treatment, and post-treatment preoperative will be colle... |
<|newrecord|> nctId: NCT06364358 id: IRB23-0385 id: 5R21DK121262 type: NIH link: https://reporter.nih.gov/quickSearch/5R21DK121262 briefTitle: Interactive Computer-adaptive Chronic Kidney Disease Education Program acronym: ICCKD overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2024-12 date: 2025-04 date: 2024-04-1... |
<|newrecord|> nctId: NCT06364345 id: INOVA_POCAD_1 briefTitle: [Trial of device that is not approved or cleared by the U.S. FDA] overallStatus: WITHHELD date: 2024-04-15 date: 2024-04-15 name: [Redacted] hasResults: False |
<|newrecord|> nctId: NCT06364332 id: ChatsafeNL id: 2023.0348 type: OTHER domain: Medical Ethics Committee VUmc briefTitle: #Chatsafe Netherlands: a Social Media Intervention to Improve Dutch Young People's Safe Communication About Suicide Online acronym: CSNL overallStatus: NOT_YET_RECRUITING date: 2024-04-04 date: 20... |
The #Chatsafe guidelines were developed by Orygen Australia to better equip young people to communicate safely about suicide on social media. These guidelines are supported by a social media campaign to make the content of the guidelines more accessible to them. The #Chatsafe intervention consists of both the guideline... |
With funding from the Dutch National Agenda for Suicide Prevention, a contextualized replication study is conducted. The aim of this study is to determine whether the #Chatsafe intervention has an effect on the way in which Dutch YP communicate online about suicide. conditions: Suicide Prevention conditions: Communicat... |
<|newrecord|> nctId: NCT06364319 id: 2024PHD002-001 briefTitle: Efficacy and Safety of Anti-CD25 rhMAb in the Treatment of Steroid-Refractory cGVHD overallStatus: NOT_YET_RECRUITING date: 2024-04-15 date: 2027-12-31 date: 2028-06-30 date: 2024-04-15 date: 2024-04-15 name: Peking University People's Hospital class: OTHE... |
<|newrecord|> nctId: NCT06364306 id: 12032024 briefTitle: oPen Versus RobotIc retrOmuscular Repair in Medium to Large Ventral Hernias acronym: PRIOR overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2026-12-31 date: 2031-12-31 date: 2024-04-15 date: 2024-04-17 name: University Hospital, Basel, Switzerland class:... |
The goal of this clinical trial is to learn if the minimally-invasive, robotically-assisted ventral hernia repair (RVHR) leads to a better outcome than the open ventral hernia repair (OVHR). |
The main questions it aims to answer are: |
length of stay after the operation rate of complications rate of recurrence and reoperations quality of life. |
Participants will: |
Either be operated using the RVHR or OVHR will be followed up either in person or via email / phone call at day 7, day 30, 6 months, 1, 3 and 5 years after the surgery to asses the above-stated main and some more outcomes. conditions: Ventral Hernia conditions: Incisional Hernia conditions: Abdominal Wall Defect studyT... |
In case for any reason the patient has been unblinded to his treatment allocation (accidental or intentional dressing removal, bed-side wound opening, other) all outcome data are assessed regardless and unblinding is documented and reported in the final report. whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count:... |
<|newrecord|> nctId: NCT06364293 id: KY2023-261-01 briefTitle: An Early Warning Model of Unfavorable Outcomes Following Endovascular Interventional Treatment of Intracranial Aneurysm overallStatus: ENROLLING_BY_INVITATION date: 2024-01-01 date: 2026-12-31 date: 2026-12-31 date: 2024-04-15 date: 2024-04-15 name: Beijing... |
<|newrecord|> nctId: NCT06364280 id: 2023X0135 id: UG3HL165019 type: NIH link: https://reporter.nih.gov/quickSearch/UG3HL165019 id: U24HL165014 type: NIH link: https://reporter.nih.gov/quickSearch/U24HL165014 briefTitle: Pediatric Prehospital Airway Resuscitation Trial acronym: Pedi-PART overallStatus: NOT_YET_RECRUITI... |
The study interventions are strategies of prehospital airway management: \[BVM-only\], \[BVM followed by SGA\] and \[BVM followed by ETI\]. |
The trial will be organized and executed in two successive stages. In Stage I of the trial, EMS personnel will alternate between two strategies: \[BVM-only\] or \[BVM followed by SGA\]. The \[winner of Stage I\] will advance to Stage II based upon results of Bayesian interim analyses. In Stage II of the trial, EMS pers... |
The interventions will be quasi-randomized using alternate day assignment. primaryPurpose: TREATMENT masking: NONE count: 3000 type: ESTIMATED name: BVM name: SGA name: ETI measure: 30-day ICU-free survival measure: Neurologic outcome upon hospital discharge sex: ALL minimumAge: 24 Hours maximumAge: 17 Years stdAges: C... |
<|newrecord|> nctId: NCT06364267 id: BabyTears briefTitle: Babytam vs Babyexe in Post-menopausal Women at High Risk for Breast Cancer. acronym: BabyTears overallStatus: NOT_YET_RECRUITING date: 2024-09-01 date: 2026-09-01 date: 2026-09-01 date: 2024-04-15 date: 2024-04-15 name: Andrea DeCensi class: OTHER name: Dana-Fa... |
<|newrecord|> nctId: NCT06364254 id: 2311054791 briefTitle: Effects of CBD on 2 Mile Run Time Trial Performance overallStatus: RECRUITING date: 2023-11-11 date: 2024-05-30 date: 2024-05-30 date: 2024-04-15 date: 2024-04-15 name: University of Northern Colorado class: OTHER briefSummary: Individuals who engage in endura... |
<|newrecord|> nctId: NCT06364241 id: 331760 id: 226706/Z/22/Z type: OTHER_GRANT domain: Wellcome Trust briefTitle: Focus Groups on Cognitive Function in Psychosis acronym: PRECOGNITION overallStatus: NOT_YET_RECRUITING date: 2024-06 date: 2024-07 date: 2026-09 date: 2024-04-15 date: 2024-04-15 name: King's College Lond... |
The findings of these focus groups will provide important information about what areas of cognition and functioning should be considered in future analyses of large fully anonymised datasets collected in the past from individuals with psychosis. The focus groups will not form part of those analyses, but will provide in... |
The second set of focus groups will enable the investigators to determine the participants' perception of potential risks and benefits associated with the dissemination of findings on cognitive function in psychosis, to ensure this is done in a manner that is sensitive to the wishes and needs of people with lived exper... |
Each participant will be asked to attend one focus group, which will last approximately one hour. Focus groups will take place at the South London and Maudsley (SLaM) Trust or at the Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, although provision will be made for participants to ... |
<|newrecord|> nctId: NCT06364228 id: 0133-24-FB briefTitle: Intranasal Oxytocin Intervention for Caregivers to Persons With Dementia overallStatus: NOT_YET_RECRUITING date: 2024-07 date: 2026-04 date: 2026-04 date: 2024-04-15 date: 2024-04-15 name: University of Nebraska class: OTHER briefSummary: The proposed study is... |
<|newrecord|> nctId: NCT06364215 id: 2024P000883 briefTitle: Posterior Wall Substrate Modification Using Irreversible Electroporation for Paroxysmal Atrial Fibrillation acronym: (SMILE-AF) overallStatus: NOT_YET_RECRUITING date: 2024-06 date: 2025-12 date: 2025-12 date: 2024-04-15 date: 2024-04-22 name: Brigham and Wom... |
<|newrecord|> nctId: NCT06364202 id: 1928368 briefTitle: Effects of Peanut Butter on Sleep Quality and Daily Energy Levels in Fire Fighters overallStatus: COMPLETED date: 2022-08-01 date: 2023-11-01 date: 2023-11-01 date: 2024-04-15 date: 2024-04-15 name: Augusta University class: OTHER briefSummary: The purpose of thi... |
Aim 2: Examine the effects of peanut butter consumption on morning and evening energy levels conditions: Sleep conditions: Body Composition conditions: Blood Pressure conditions: Physical Activity studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: OTHER masking: SING... |
<|newrecord|> nctId: NCT06364189 id: FY22-119 id: R61AG084479 type: NIH link: https://reporter.nih.gov/quickSearch/R61AG084479 briefTitle: Inspiring Seniors Toward Exercise Promotion acronym: iSTEP overallStatus: RECRUITING date: 2024-04-15 date: 2025-04-30 date: 2025-04-30 date: 2024-04-15 date: 2024-04-15 name: Unive... |
To test the effects of BMS on PA, participants will be randomly assigned to an exercise intervention that either includes BMS or does not include BMS. Participants will attend a supervised group strength training (ST) (30 min/day) and aerobic exercise (AE) (30-50 min/day) session for 3 days/week for the first 2 months,... |
<|newrecord|> nctId: NCT06364176 id: STUDY00149479 briefTitle: Targeting Inflammation With Losartan to Improve Response to Modulator Therapy in Cystic Fibrosis. overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2027-05 date: 2027-10 date: 2024-04-15 date: 2024-04-22 name: University of Kansas Medical Center class: ... |
Participants will be asked take losartan or placebo for twelve weeks and will have changes in sweat chloride levels measured as a marker of CFTR function. conditions: Cystic Fibrosis studyType: INTERVENTIONAL phases: PHASE2 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE who... |
<|newrecord|> nctId: NCT06364163 id: 697716 briefTitle: Effect of Herring Oil Concentrate on LDL Cholesterol Concentration in Adults overallStatus: NOT_YET_RECRUITING date: 2024-08-12 date: 2026-12-31 date: 2027-12-31 date: 2024-04-15 date: 2024-04-15 name: University of Bergen class: OTHER name: The Norwegian Seafood ... |
<|newrecord|> nctId: NCT06364150 id: MAGIC6 briefTitle: Therapeutic Use of Angiopoietin-Primed Autologous Peripheral Blood Stem Cell in Myocardial Infarction acronym: MAGICcell6 overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2025-05-01 date: 2026-08-01 date: 2024-04-15 date: 2024-04-15 name: Seoul National Ho... |
<|newrecord|> nctId: NCT06364137 id: 73203 briefTitle: Engagement and Clinical Impact of the Teleo Virtual Therapy Platform in Clinical Settings - Pilot RCT overallStatus: NOT_YET_RECRUITING date: 2024-07-01 date: 2025-06-30 date: 2025-06-30 date: 2024-04-15 date: 2024-04-15 name: Stanford University class: OTHER name:... |
Engagement will be assessed using well-established measures - PRIME-O (modified) video coding, MTT-Y/MTTCG and attendance data (sessions 1-4). Clinicians in the study will deliver therapy to clients for 4 sessions, providing opportunity to measure temporal sustainment of any engagement differences. conditions: Anxiety ... |
<|newrecord|> nctId: NCT06364124 id: Beijing_LH_CCU2024 briefTitle: Effects of PCSK-9 Inhibitor Treatment Prior to Undergoing Primary Percutaneous Coronary Intervention in Patients With ST-segment Elevation Myocardial Infarction overallStatus: RECRUITING date: 2023-06-01 date: 2024-06-01 date: 2025-06-01 date: 2024-04-... |
<|newrecord|> nctId: NCT06364111 id: Vibrabot Capsule briefTitle: Comparative Study on the Efficacy of Vibrabot Capsule and Polyethylene Glycol for Chronic Functional Constipation overallStatus: RECRUITING date: 2024-01-08 date: 2025-06-14 date: 2025-08-30 date: 2024-04-15 date: 2024-04-15 name: Beijing Tsinghua Chang ... |
<|newrecord|> nctId: NCT06364098 id: prevention of PPH briefTitle: Comparative Study Between the Roles of Intrauterine Misoprostol Versus the Sublingual Route for Prevention of Postpartum Blood Loss in Elective Cesarean Sections overallStatus: COMPLETED date: 2022-01-01 date: 2023-02-01 date: 2023-02-01 date: 2024-04-1... |
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