harpreetmann/entity_extraction_ade · Datasets at Hugging Face

text stringlengths 22 455	pairs listlengths 1 24
Clinicians should be aware of the signs and symptoms of neurotoxicity during treatment, as well as predisposing factors that put patients receiving methotrexate at risk for neurotoxic effects.	[ [ "methotrexate", "neurotoxicity" ] ]
In one case, the readministration of riluzole was followed by the relapse of hepatitis.	[ [ "riluzole", "hepatitis" ] ]
Retrospectively, bucillamine was believed to be the cause of the giant hypertrophy because of its structural similarity to D-penicillamine, which was the subject of an abundance of reports of mammary hyperplasia.	[ [ "D-penicillamine", "mammary hyperplasia" ], [ "bucillamine", "giant hypertrophy" ] ]
The authors report a case of acute pancreatitis (AP) occurring in a patient under treatment with carbamazepine (CBZ) for post-traumatic petit mal epilepsy, and review the current literature of drug-induced AP.	[ [ "CBZ", "pancreatitis" ], [ "carbamazepine", "pancreatitis" ] ]
Levofloxacin induced polymorphic ventricular tachycardia with normal QT interval.	[ [ "Levofloxacin", "polymorphic ventricular tachycardia" ] ]
A patient with acute esophageal variceal bleeding developed fatal rhabdomyolysis during treatment with a continuous intravenous infusion of vasopressin.	[ [ "vasopressin", "fatal rhabdomyolysis" ] ]
In view of our experience in the present case, it should be stressed that close monitoring of coagulation capacity is necessary in critically ill patients in order to avoid fatal haemorrhage after initiating warfarin therapy regardless of the dosage.	[ [ "warfarin", "fatal haemorrhage" ] ]
We present a case of HUS in an advanced ovarian cancer patient treated with carboplatin and gemcitabine, and described its favorable outcome after chemotherapy interruption and supportive care with a 1 year follow-up.	[ [ "carboplatin", "HUS" ], [ "gemcitabine", "HUS" ] ]
The dermatology literature heretofore has not noted that anemia is a side effect of patients taking MMF to treat pemphigus.	[ [ "MMF", "anemia" ] ]
Skin rash and splinter hemorrhages from ganciclovir.	[ [ "ganciclovir", "Skin rash" ], [ "ganciclovir", "splinter hemorrhages" ] ]
Atrial fibrillation after vardenafil therapy.	[ [ "vardenafil", "Atrial fibrillation" ] ]
A chronic reaction associated with long-term treatment with nitrofurantoin has also been reported and causes irreversible pulmonary fibrosis.	[ [ "nitrofurantoin", "pulmonary fibrosis" ] ]
Alprazolam withdrawal delirium unresponsive to diazepam: case report.	[ [ "Alprazolam", "delirium" ] ]
We discuss a patient who developed severe renal tubular dysfunction secondary to short-term therapy with Amikacin, resulting in refractory hypokalemia, hypocalcemia, hypomagnesemia, metabolic alkalosis, and polyuria.	[ [ "Amikacin", "polyuria" ], [ "Amikacin", "refractory hypokalemia" ], [ "Amikacin", "severe renal tubular dysfunction" ], [ "Amikacin", "metabolic alkalosis" ], [ "Amikacin", "hypocalcemia" ], [ "Amikacin", "hypomagnesemia" ] ]
Four patients in whom pulmonary oedema developed during tocolysis with hexoprenaline are described and the aetiological factors and pathogenesis of this potentially lethal complication discussed.	[ [ "hexoprenaline", "pulmonary oedema" ] ]
Warfarin-associated bleeding complication saved life.	[ [ "Warfarin", "bleeding" ] ]
Minimal change nephrotic syndrome developing during postoperative interferon-beta therapy for malignant melanoma.	[ [ "interferon-beta", "Minimal change nephrotic syndrome" ] ]
Sorafenib induced tumor lysis syndrome in an advanced hepatocellular carcinoma patient.	[ [ "Sorafenib", "tumor lysis syndrome" ] ]
This case extends the spectrum of fludarabine pulmonary toxicity to include pulmonary nodules.	[ [ "fludarabine", "pulmonary nodules" ], [ "fludarabine", "pulmonary toxicity" ] ]
He had been taking trimethoprim-sulfamethoxazole for approximately eight days when he revisited his family physician, complaining of headaches, dizziness, difficulty with speech, weakness, and itching on the trunk of his body and legs, where a maculopapular rash was noted.	[ [ "trimethoprim", "weakness" ], [ "trimethoprim", "itching on the trunk" ], [ "sulfamethoxazole", "itching on the trunk" ], [ "sulfamethoxazole", "maculopapular rash" ], [ "trimethoprim", "maculopapular rash" ], [ "sulfamethoxazole", "headaches" ], [ "sulfamethoxazole", "difficulty with speech" ], [ "sulfamethoxazole", "weakness" ], [ "sulfamethoxazole", "dizziness" ], [ "trimethoprim", "dizziness" ], [ "trimethoprim", "difficulty with speech" ], [ "trimethoprim", "headaches" ] ]
Enoxaparin-induced generalized exanthem.	[ [ "Enoxaparin", "generalized exanthem" ] ]
CCBs should be considered in the treatment of 5-FU or capecitabine-induced headaches.	[ [ "capecitabine", "headaches" ], [ "5-FU", "headaches" ] ]
We report a case of a young woman with SLE and thrombocytopenia, who developed severe perspiration, headache, and seizure after receiving cyclosporine.	[ [ "cyclosporine", "headache" ], [ "cyclosporine", "seizure" ], [ "cyclosporine", "severe perspiration" ] ]
OBJECTIVE: To report 2 cases of nonconvulsive status epilepticus (NCSE) following infusion of ifosfamide.	[ [ "ifosfamide", "nonconvulsive status epilepticus" ], [ "ifosfamide", "NCSE" ] ]
We report three cases of IFN beta induced hepatitis in MS and discuss the pathology findings and possible mechanisms of drug-induced liver injury.	[ [ "IFN beta", "hepatitis" ], [ "IFN beta", "liver injury" ] ]
Thus, the eosinophilia myalgia syndrome can be associated with parenteral tryptophan administration.	[ [ "tryptophan", "eosinophilia myalgia syndrome" ] ]
DISCUSSION: To our knowledge, this is the first case report illustrating neuralgic amyotrophy triggered by exposure to the antibiotics vancomycin, tobramycin, and piperacillin/tazobactam.	[ [ "tazobactam", "neuralgic amyotrophy" ], [ "piperacillin", "neuralgic amyotrophy" ], [ "vancomycin", "neuralgic amyotrophy" ], [ "tobramycin", "neuralgic amyotrophy" ] ]
Celiprolol pneumonitis.	[ [ "Celiprolol", "pneumonitis" ] ]
PURPOSE: To report two cases in which topical brimonidine resulted in apparent central nervous system depression and unresponsiveness in an infant.	[ [ "brimonidine", "central nervous system depression" ] ]
However, given the clinically significant result to the interaction between tolazoline and cimetidine we report, the use of cimetidine in tolazoline induced upper gastrointestinal hemorrhage should deserve more attention.	[ [ "tolazoline", "upper gastrointestinal hemorrhage" ], [ "cimetidine", "upper gastrointestinal hemorrhage" ] ]
Divalproex sodium-induced eosinophilic pleural effusion.	[ [ "Divalproex sodium", "eosinophilic pleural effusion" ] ]
Managing cardiovascular collapse in severe flecainide overdose without recourse to extracorporeal therapy.	[ [ "flecainide", "cardiovascular collapse" ] ]
Rebound hyperglycemia following overdosing of insulin in cats with diabetes mellitus.	[ [ "insulin", "hyperglycemia" ] ]
OBJECTIVE: To report a case of reversible nonthrombocytopenic palpable purpura associated with metoclopramide.	[ [ "metoclopramide", "nonthrombocytopenic palpable purpura" ] ]
Presently, treatment of acute ibuprofen intoxication with complications requires supportive therapy until the symptoms resolve over 24 to 48 hours.	[ [ "ibuprofen", "ibuprofen intoxication" ] ]
Atrial fibrillation following methylprednisolone pulse therapy.	[ [ "methylprednisolone", "Atrial fibrillation" ] ]
Anaphylactoid reactions with intraperitoneal cisplatin.	[ [ "cisplatin", "Anaphylactoid reactions" ] ]
Patient A reported right leg weakness (foot drop) during week 4 of CAP-XRT (1600 mg/m2).	[ [ "CAP-XRT", "foot drop" ], [ "CAP-XRT", "right leg weakness" ] ]
The authors report a longitudinal case study of a woman with a history of bipolar affective disorder in which L-dopa shortened the manic-depressive cycle length when administered in a double-blind trial.	[ [ "L-dopa", "shortened the manic-depressive cycle" ] ]
Propylthiouracil-induced cutaneous vasculitis.	[ [ "Propylthiouracil", "cutaneous vasculitis" ] ]
OBJECTIVE: To report a case of cutaneous and hematologic toxicity in a patient treated with IL-2.	[ [ "IL-2", "cutaneous and hematologic toxicity" ] ]
Acute renal insufficiency is known to occur in patients who are taking ciprofloxacin, particularly the elderly.	[ [ "ciprofloxacin", "Acute renal insufficiency" ] ]
EEG abnormalities were observed in two of the nine children during chlorambucil therapy.	[ [ "chlorambucil", "EEG abnormalities" ] ]
METHODS: A patient who developed dramatic, permanent vision loss after a 9-month course of treatment with ethambutol and isoniazid for pulmonary tuberculosis is presented.	[ [ "isoniazid", "vision loss" ], [ "ethambutol", "vision loss" ] ]
Erythromycin is a macrolide antibiotic that may increase the risk of lovastatin-induced rhabdomyolysis.	[ [ "Erythromycin", "rhabdomyolysis" ], [ "lovastatin", "rhabdomyolysis" ] ]
We report 2 cases of maculopapular eruption and fever in patients infected with human immunodeficiency virus (HIV) on the 2nd day of first administration of ritonavir, a protease inhibitor.	[ [ "ritonavir", "fever" ], [ "ritonavir", "maculopapular eruption" ] ]
A patient with disseminated herpes zoster developed a syndrome of inappropriate antidiuretic hormone and profound hyponatremia secondary to the administration of adenine arabinoside.	[ [ "adenine arabinoside", "hyponatremia" ], [ "adenine arabinoside", "syndrome of inappropriate antidiuretic hormone" ] ]
An episode of subacute encephalopathy after the infusion of a moderate dose of methotrexate (1500 mg/m2) (MTX) is reported in a young adult with metastastic gastric cancer.	[ [ "methotrexate", "encephalopathy" ] ]
She developed a severe urticarial rash 3 weeks following initiation of therapy with Enoxaparin.	[ [ "Enoxaparin", "severe urticarial rash" ] ]
Pellagra should be suspected whenever tuberculous patients under treatment with isoniazid develop mental, neurological or gastrointestinal symptoms, even in the absence of typical pellagra dermatitis.	[ [ "isoniazid", "mental, neurological or gastrointestinal symptoms" ] ]
Currently the use of zidovudine is one of the few specific measures available, and as a potentially teratogenic and fetotoxic agent, any decision for its use requires evaluation of the potential for fetal damage.	[ [ "zidovudine", "teratogenic" ], [ "zidovudine", "fetotoxic" ], [ "zidovudine", "fetal damage" ] ]
In one child, a second course of carbamazepine resulted in a return of the dystonia.	[ [ "carbamazepine", "dystonia" ] ]
In this healthy population, the relative risk of developing endometrial carcinoma in the tamoxifen arm was 2.54, although when stratified by age, in women over 50, the risk grew to 4.01.	[ [ "tamoxifen", "endometrial carcinoma" ] ]
We report two young patients with cystic fibrosis who presented with acute renal insufficiency after 2-3 weeks of oral ciprofloxacin therapy.	[ [ "ciprofloxacin", "acute renal insufficiency" ] ]
CASE: We report a case of a woman with severe human insulin-induced lipoatrophy who has been treated exclusively with recombinant DNA human insulin since the onset of IDDM.	[ [ "human insulin", "lipoatrophy" ], [ "recombinant DNA human insulin", "lipoatrophy" ] ]
The authors describe a case of combined lithium and haloperidol toxicity characterized by hyperpyrexia, severe rigidity, mutism, and development of irreversible tardive dyskinesia.	[ [ "lithium", "hyperpyrexia" ], [ "haloperidol", "hyperpyrexia" ], [ "lithium", "irreversible tardive dyskinesia" ], [ "haloperidol", "mutism" ], [ "haloperidol", "irreversible tardive dyskinesia" ], [ "lithium", "mutism" ], [ "haloperidol", "severe rigidity" ], [ "lithium", "severe rigidity" ] ]
RESULTS: A previously healthy 42-year-old woman presented with acute-onset delirium with psychotic features as a consequence of levofloxacin therapy.	[ [ "levofloxacin", "acute-onset delirium with psychotic features" ] ]
An objective causality assessment by use of the Naranjo probability scale revealed that NCSE due to ifosfamide was probable.	[ [ "ifosfamide", "NCSE" ] ]
Neuropathy is a significant side effect of thalidomide therapy, which may limit its clinical use.	[ [ "thalidomide", "Neuropathy" ] ]
Clinical course of macular edema in two cases of interferon-associated retinopathy observed by optical coherence tomography.	[ [ "interferon", "macular edema" ], [ "interferon", "retinopathy" ] ]
In a single practice during the 21 years 1971-1991, the incidence of gestational diabetes in pregnancies in which norethisterone was prescribed was 32.4% (22 of 69) in comparison with 7.1% in pregnancies in which the women did not take norethisterone (137 of 1,684) (p < 0.001).	[ [ "norethisterone", "gestational diabetes" ] ]
Leiomyosarcoma in urinary bladder after cyclophosphamide therapy for retinoblastoma and review of bladder sarcomas.	[ [ "cyclophosphamide", "Leiomyosarcoma" ] ]
A study following large patient groups on theophylline and a combination of theophylline and steroids might clarify the risk of ulcer formation in patients being treated with these medications for asthma.	[ [ "theophylline", "ulcer" ] ]
Inhaled tobramycin solution-associated recurrent eosinophilia and severe persistent bronchospasm in a patient with cystic fibrosis: a case report.	[ [ "tobramycin", "severe persistent bronchospasm" ], [ "tobramycin", "recurrent eosinophilia" ] ]
The hearing impairment and tinnitus were gradually reduced after PTU withdrawal and corticosteroid and azathioprine treatment.	[ [ "PTU", "tinnitus" ], [ "PTU", "hearing impairment" ] ]
We report two patients with infectious mononucleosis-like syndrome induced by salazosulfapyridine (SASP).	[ [ "SASP", "infectious mononucleosis-like syndrome" ], [ "salazosulfapyridine", "infectious mononucleosis-like syndrome" ] ]
Hydroxyurea-induced acute interstitial pneumonitis in a patient with essential thrombocythemia.	[ [ "Hydroxyurea", "acute interstitial pneumonitis" ] ]
Massive plasmocytosis due to methimazole-induced bone marrow toxicity.	[ [ "methimazole", "Massive plasmocytosis" ], [ "methimazole", "bone marrow toxicity" ] ]
The patient expired after seven cycles of treatment had been completed because of pulmonary fibrosis and the drug toxicity of bleomycin.	[ [ "bleomycin", "pulmonary fibrosis" ] ]
Presented is a case story of a woman with classical rheumatoid arthritis, who during introduction of sulphasalazine (SASP) therapy developed a severe and lasting psoriasis-like skin reaction.	[ [ "sulphasalazine", "psoriasis-like skin reaction" ], [ "SASP", "psoriasis-like skin reaction" ] ]
Cefoxitin-associated renal failure.	[ [ "Cefoxitin", "renal failure" ] ]
Baclofen withdrawal syndrome resulting from underdosing of oral baclofen should be considered as a potential source of prolonged fever in the intensive care unit.	[ [ "Baclofen", "withdrawal syndrome" ], [ "baclofen", "withdrawal syndrome" ] ]
Four cases of adverse experiences with clonidine are described.	[ [ "clonidine", "adverse experiences" ] ]
We describe a 10-year-old boy with ulcerative colitis who developed acute pancreatitis while on long-term treatment with 5-aminosalicylic acid.	[ [ "5-aminosalicylic acid", "acute pancreatitis" ] ]
A 50-year-old woman with a history of migraine without aura, predominantly occurring around her menstrual periods, developed a spinal cord lesion following the use of zolmitriptan.	[ [ "zolmitriptan", "spinal cord lesion" ] ]
IV propranolol was used as the initial treatment for his hyperadrenergic state, resulting in a decrease in heart rate but a paroxsymal increase in blood pressure.	[ [ "propranolol", "paroxsymal increase in blood pressure" ], [ "propranolol", "decrease in heart rate" ] ]
Ptosis occurring 24 h after chloroquine therapy, with full recovery 48 h after cessation of chloroquine, has not been described previously.	[ [ "chloroquine", "Ptosis" ] ]
An unusual presentation of spontaneous sub-conjunctival haematoma in a patient receiving warfarin.	[ [ "warfarin", "sub-conjunctival haematoma" ] ]
Here, we present a case of sirolimus-associated interstitial pneumonitis in a cardiac transplant recipient that resolved completely with withdrawal of the drug and treatment with corticosteroids.	[ [ "sirolimus", "interstitial pneumonitis" ] ]
Thirty patients with hepatic reactions to cyclofenil, a non-steroidal drug with a stimulating effect on ovulation, are reviewed.	[ [ "cyclofenil", "hepatic reactions" ] ]
Cutaneous necrosis after injection of polyethylene glycol-modified interferon alfa.	[ [ "interferon alfa", "Cutaneous necrosis" ] ]
From 1996 to 2002 several medications were changed due to their adverse effects: indinavir (renal colic and fever), nelfinavir (cutaneous rash), and efavirenz (nausea and temporary memory loss).	[ [ "indinavir", "renal colic" ], [ "indinavir", "fever" ], [ "nelfinavir", "cutaneous rash" ], [ "efavirenz", "nausea" ], [ "efavirenz", "temporary memory loss" ] ]
In one patient, treatment with DCA was associated with a decrease in blood lactate levels from 11.2 mM before treatment to 0.8 mM 16 h later.	[ [ "DCA", "decrease in blood lactate levels" ] ]
A second possibility is an interaction between clarithromycin and isradipine, potentially increasing the hepatic toxicity of isradipine.	[ [ "isradipine", "increasing the hepatic toxicity" ], [ "clarithromycin", "increasing the hepatic toxicity" ] ]
We describe 2 patients with prior amputation who experienced phantom limb pain (PLP) after receiving paclitaxel therapy.	[ [ "paclitaxel", "phantom limb pain" ], [ "paclitaxel", "PLP" ] ]
Acute dystonia induced by lamivudine.	[ [ "lamivudine", "Acute dystonia" ] ]
Anastrozole-associated sclerosing glomerulonephritis in a patient with breast cancer.	[ [ "Anastrozole", "sclerosing glomerulonephritis" ] ]
Treatment of ELP in children is generally supportive, with the symptoms and roentgenographic abnormalities resolving within months after stopping the use of mineral oil.	[ [ "mineral oil", "roentgenographic abnormalities" ], [ "mineral oil", "ELP" ] ]
Two children with rheumatic fever developed anicteric hepatitis while on high-dose aspirin therapy.	[ [ "aspirin", "anicteric hepatitis" ] ]
Charcoal haemoperfusion and cysteamine therapy led to the rapid removal of the paracetamol from the body and consequently prevented the development of severe hepatic necrosis.	[ [ "paracetamol", "severe hepatic necrosis" ] ]
However, 1 eye had vitreous hemorrhage after repeated injections of tPA.	[ [ "tPA", "vitreous hemorrhage" ] ]
We report an additional case of isotretinoin teratogenicity in which the patient had agenesis of the cerebellar vermis, multiple leptomeningeal neuroglial heterotopias, hydrocephalus, and abnormalities of the corticospinal tracts.	[ [ "isotretinoin", "teratogenicity" ], [ "isotretinoin", "agenesis of the cerebellar vermis" ], [ "isotretinoin", "multiple leptomeningeal neuroglial heterotopias" ], [ "isotretinoin", "hydrocephalus" ], [ "isotretinoin", "abnormalities of the corticospinal tracts" ] ]
Cataracts induced by intermittent Decadron used as an antiemetic.	[ [ "Decadron", "Cataracts" ] ]
Diclofenac-associated hepatitis.	[ [ "Diclofenac", "hepatitis" ] ]
This case study is the second report of localized purpura after prolonged lamotrigine treatment suggesting this may be an atypical lamotrigine-induced drug reaction.	[ [ "lamotrigine", "localized purpura" ] ]
Initial treatment with heparin was substituted with thrombolysis, which resulted in clinical improvement and dissolution of right heart thrombus but was followed by fatal intracerebral haemorrhage.	[ [ "heparin", "fatal intracerebral haemorrhage" ] ]
Atrial fibrillation occurring in a patient taking etanercept plus methotrexate for rheumatoid arthritis.	[ [ "etanercept", "Atrial fibrillation" ], [ "methotrexate", "Atrial fibrillation" ] ]
We describe the case of a nonatopic 17-year-old girl with bronchial asthma and aspirin intolerance who developed a dramatic anaphylactic reaction to oral prednisone.	[ [ "prednisone", "anaphylactic reaction" ] ]
This case demonstrates an occupational activity (construction) that has now become the dominant source of lead exposure for U.S. adults, the importance of a good occupational history to suspecting and making a diagnosis, the possible outcomes of chronic lead toxicity, and the importance of preventing further exposure and using proper methods to treat acute toxicity.	[ [ "lead", "lead toxicity" ] ]
Risperidone-induced psychosis and depression in a child with a mitochondrial disorder.	[ [ "Risperidone", "depression" ], [ "Risperidone", "psychosis" ] ]

Clinicians should be aware of the signs and symptoms of neurotoxicity during treatment, as well as predisposing factors that put patients receiving methotrexate at risk for neurotoxic effects.

[ [ "methotrexate", "neurotoxicity" ] ]

In one case, the readministration of riluzole was followed by the relapse of hepatitis.

[ [ "riluzole", "hepatitis" ] ]

Retrospectively, bucillamine was believed to be the cause of the giant hypertrophy because of its structural similarity to D-penicillamine, which was the subject of an abundance of reports of mammary hyperplasia.

[ [ "D-penicillamine", "mammary hyperplasia" ], [ "bucillamine", "giant hypertrophy" ] ]

The authors report a case of acute pancreatitis (AP) occurring in a patient under treatment with carbamazepine (CBZ) for post-traumatic petit mal epilepsy, and review the current literature of drug-induced AP.

[ [ "CBZ", "pancreatitis" ], [ "carbamazepine", "pancreatitis" ] ]

Levofloxacin induced polymorphic ventricular tachycardia with normal QT interval.

[ [ "Levofloxacin", "polymorphic ventricular tachycardia" ] ]

A patient with acute esophageal variceal bleeding developed fatal rhabdomyolysis during treatment with a continuous intravenous infusion of vasopressin.

[ [ "vasopressin", "fatal rhabdomyolysis" ] ]

In view of our experience in the present case, it should be stressed that close monitoring of coagulation capacity is necessary in critically ill patients in order to avoid fatal haemorrhage after initiating warfarin therapy regardless of the dosage.

[ [ "warfarin", "fatal haemorrhage" ] ]

We present a case of HUS in an advanced ovarian cancer patient treated with carboplatin and gemcitabine, and described its favorable outcome after chemotherapy interruption and supportive care with a 1 year follow-up.

[ [ "carboplatin", "HUS" ], [ "gemcitabine", "HUS" ] ]

The dermatology literature heretofore has not noted that anemia is a side effect of patients taking MMF to treat pemphigus.

[ [ "MMF", "anemia" ] ]

Skin rash and splinter hemorrhages from ganciclovir.

[ [ "ganciclovir", "Skin rash" ], [ "ganciclovir", "splinter hemorrhages" ] ]

Atrial fibrillation after vardenafil therapy.

[ [ "vardenafil", "Atrial fibrillation" ] ]

A chronic reaction associated with long-term treatment with nitrofurantoin has also been reported and causes irreversible pulmonary fibrosis.

[ [ "nitrofurantoin", "pulmonary fibrosis" ] ]

Alprazolam withdrawal delirium unresponsive to diazepam: case report.

[ [ "Alprazolam", "delirium" ] ]

We discuss a patient who developed severe renal tubular dysfunction secondary to short-term therapy with Amikacin, resulting in refractory hypokalemia, hypocalcemia, hypomagnesemia, metabolic alkalosis, and polyuria.

[ [ "Amikacin", "polyuria" ], [ "Amikacin", "refractory hypokalemia" ], [ "Amikacin", "severe renal tubular dysfunction" ], [ "Amikacin", "metabolic alkalosis" ], [ "Amikacin", "hypocalcemia" ], [ "Amikacin", "hypomagnesemia" ] ]

Four patients in whom pulmonary oedema developed during tocolysis with hexoprenaline are described and the aetiological factors and pathogenesis of this potentially lethal complication discussed.

[ [ "hexoprenaline", "pulmonary oedema" ] ]

Warfarin-associated bleeding complication saved life.

[ [ "Warfarin", "bleeding" ] ]

Minimal change nephrotic syndrome developing during postoperative interferon-beta therapy for malignant melanoma.

[ [ "interferon-beta", "Minimal change nephrotic syndrome" ] ]

Sorafenib induced tumor lysis syndrome in an advanced hepatocellular carcinoma patient.

[ [ "Sorafenib", "tumor lysis syndrome" ] ]

This case extends the spectrum of fludarabine pulmonary toxicity to include pulmonary nodules.

[ [ "fludarabine", "pulmonary nodules" ], [ "fludarabine", "pulmonary toxicity" ] ]

He had been taking trimethoprim-sulfamethoxazole for approximately eight days when he revisited his family physician, complaining of headaches, dizziness, difficulty with speech, weakness, and itching on the trunk of his body and legs, where a maculopapular rash was noted.

[ [ "trimethoprim", "weakness" ], [ "trimethoprim", "itching on the trunk" ], [ "sulfamethoxazole", "itching on the trunk" ], [ "sulfamethoxazole", "maculopapular rash" ], [ "trimethoprim", "maculopapular rash" ], [ "sulfamethoxazole", "headaches" ], [ "sulfamethoxazole", "difficulty with speech" ], [ "sulfamethoxazole", "weakness" ], [ "sulfamethoxazole", "dizziness" ], [ "trimethoprim", "dizziness" ], [ "trimethoprim", "difficulty with speech" ], [ "trimethoprim", "headaches" ] ]

Enoxaparin-induced generalized exanthem.

[ [ "Enoxaparin", "generalized exanthem" ] ]

CCBs should be considered in the treatment of 5-FU or capecitabine-induced headaches.

[ [ "capecitabine", "headaches" ], [ "5-FU", "headaches" ] ]

We report a case of a young woman with SLE and thrombocytopenia, who developed severe perspiration, headache, and seizure after receiving cyclosporine.

[ [ "cyclosporine", "headache" ], [ "cyclosporine", "seizure" ], [ "cyclosporine", "severe perspiration" ] ]

OBJECTIVE: To report 2 cases of nonconvulsive status epilepticus (NCSE) following infusion of ifosfamide.

[ [ "ifosfamide", "nonconvulsive status epilepticus" ], [ "ifosfamide", "NCSE" ] ]

We report three cases of IFN beta induced hepatitis in MS and discuss the pathology findings and possible mechanisms of drug-induced liver injury.

[ [ "IFN beta", "hepatitis" ], [ "IFN beta", "liver injury" ] ]

Thus, the eosinophilia myalgia syndrome can be associated with parenteral tryptophan administration.

[ [ "tryptophan", "eosinophilia myalgia syndrome" ] ]

DISCUSSION: To our knowledge, this is the first case report illustrating neuralgic amyotrophy triggered by exposure to the antibiotics vancomycin, tobramycin, and piperacillin/tazobactam.

[ [ "tazobactam", "neuralgic amyotrophy" ], [ "piperacillin", "neuralgic amyotrophy" ], [ "vancomycin", "neuralgic amyotrophy" ], [ "tobramycin", "neuralgic amyotrophy" ] ]

Celiprolol pneumonitis.

[ [ "Celiprolol", "pneumonitis" ] ]

PURPOSE: To report two cases in which topical brimonidine resulted in apparent central nervous system depression and unresponsiveness in an infant.

[ [ "brimonidine", "central nervous system depression" ] ]

However, given the clinically significant result to the interaction between tolazoline and cimetidine we report, the use of cimetidine in tolazoline induced upper gastrointestinal hemorrhage should deserve more attention.

[ [ "tolazoline", "upper gastrointestinal hemorrhage" ], [ "cimetidine", "upper gastrointestinal hemorrhage" ] ]

Divalproex sodium-induced eosinophilic pleural effusion.

[ [ "Divalproex sodium", "eosinophilic pleural effusion" ] ]

Managing cardiovascular collapse in severe flecainide overdose without recourse to extracorporeal therapy.

[ [ "flecainide", "cardiovascular collapse" ] ]

Rebound hyperglycemia following overdosing of insulin in cats with diabetes mellitus.

[ [ "insulin", "hyperglycemia" ] ]

OBJECTIVE: To report a case of reversible nonthrombocytopenic palpable purpura associated with metoclopramide.

[ [ "metoclopramide", "nonthrombocytopenic palpable purpura" ] ]

Presently, treatment of acute ibuprofen intoxication with complications requires supportive therapy until the symptoms resolve over 24 to 48 hours.

[ [ "ibuprofen", "ibuprofen intoxication" ] ]

Atrial fibrillation following methylprednisolone pulse therapy.

[ [ "methylprednisolone", "Atrial fibrillation" ] ]

Anaphylactoid reactions with intraperitoneal cisplatin.

[ [ "cisplatin", "Anaphylactoid reactions" ] ]

Patient A reported right leg weakness (foot drop) during week 4 of CAP-XRT (1600 mg/m2).

[ [ "CAP-XRT", "foot drop" ], [ "CAP-XRT", "right leg weakness" ] ]

The authors report a longitudinal case study of a woman with a history of bipolar affective disorder in which L-dopa shortened the manic-depressive cycle length when administered in a double-blind trial.

[ [ "L-dopa", "shortened the manic-depressive cycle" ] ]

Propylthiouracil-induced cutaneous vasculitis.

[ [ "Propylthiouracil", "cutaneous vasculitis" ] ]

OBJECTIVE: To report a case of cutaneous and hematologic toxicity in a patient treated with IL-2.

[ [ "IL-2", "cutaneous and hematologic toxicity" ] ]

Acute renal insufficiency is known to occur in patients who are taking ciprofloxacin, particularly the elderly.

[ [ "ciprofloxacin", "Acute renal insufficiency" ] ]

EEG abnormalities were observed in two of the nine children during chlorambucil therapy.

[ [ "chlorambucil", "EEG abnormalities" ] ]

METHODS: A patient who developed dramatic, permanent vision loss after a 9-month course of treatment with ethambutol and isoniazid for pulmonary tuberculosis is presented.

[ [ "isoniazid", "vision loss" ], [ "ethambutol", "vision loss" ] ]

Erythromycin is a macrolide antibiotic that may increase the risk of lovastatin-induced rhabdomyolysis.

[ [ "Erythromycin", "rhabdomyolysis" ], [ "lovastatin", "rhabdomyolysis" ] ]

We report 2 cases of maculopapular eruption and fever in patients infected with human immunodeficiency virus (HIV) on the 2nd day of first administration of ritonavir, a protease inhibitor.

[ [ "ritonavir", "fever" ], [ "ritonavir", "maculopapular eruption" ] ]

A patient with disseminated herpes zoster developed a syndrome of inappropriate antidiuretic hormone and profound hyponatremia secondary to the administration of adenine arabinoside.

[ [ "adenine arabinoside", "hyponatremia" ], [ "adenine arabinoside", "syndrome of inappropriate antidiuretic hormone" ] ]

An episode of subacute encephalopathy after the infusion of a moderate dose of methotrexate (1500 mg/m2) (MTX) is reported in a young adult with metastastic gastric cancer.

[ [ "methotrexate", "encephalopathy" ] ]

She developed a severe urticarial rash 3 weeks following initiation of therapy with Enoxaparin.

[ [ "Enoxaparin", "severe urticarial rash" ] ]

Pellagra should be suspected whenever tuberculous patients under treatment with isoniazid develop mental, neurological or gastrointestinal symptoms, even in the absence of typical pellagra dermatitis.

[ [ "isoniazid", "mental, neurological or gastrointestinal symptoms" ] ]

Currently the use of zidovudine is one of the few specific measures available, and as a potentially teratogenic and fetotoxic agent, any decision for its use requires evaluation of the potential for fetal damage.

[ [ "zidovudine", "teratogenic" ], [ "zidovudine", "fetotoxic" ], [ "zidovudine", "fetal damage" ] ]

In one child, a second course of carbamazepine resulted in a return of the dystonia.

[ [ "carbamazepine", "dystonia" ] ]

In this healthy population, the relative risk of developing endometrial carcinoma in the tamoxifen arm was 2.54, although when stratified by age, in women over 50, the risk grew to 4.01.

[ [ "tamoxifen", "endometrial carcinoma" ] ]

We report two young patients with cystic fibrosis who presented with acute renal insufficiency after 2-3 weeks of oral ciprofloxacin therapy.

[ [ "ciprofloxacin", "acute renal insufficiency" ] ]

CASE: We report a case of a woman with severe human insulin-induced lipoatrophy who has been treated exclusively with recombinant DNA human insulin since the onset of IDDM.

[ [ "human insulin", "lipoatrophy" ], [ "recombinant DNA human insulin", "lipoatrophy" ] ]

The authors describe a case of combined lithium and haloperidol toxicity characterized by hyperpyrexia, severe rigidity, mutism, and development of irreversible tardive dyskinesia.

[ [ "lithium", "hyperpyrexia" ], [ "haloperidol", "hyperpyrexia" ], [ "lithium", "irreversible tardive dyskinesia" ], [ "haloperidol", "mutism" ], [ "haloperidol", "irreversible tardive dyskinesia" ], [ "lithium", "mutism" ], [ "haloperidol", "severe rigidity" ], [ "lithium", "severe rigidity" ] ]

RESULTS: A previously healthy 42-year-old woman presented with acute-onset delirium with psychotic features as a consequence of levofloxacin therapy.

[ [ "levofloxacin", "acute-onset delirium with psychotic features" ] ]

An objective causality assessment by use of the Naranjo probability scale revealed that NCSE due to ifosfamide was probable.

[ [ "ifosfamide", "NCSE" ] ]

Neuropathy is a significant side effect of thalidomide therapy, which may limit its clinical use.

[ [ "thalidomide", "Neuropathy" ] ]

Clinical course of macular edema in two cases of interferon-associated retinopathy observed by optical coherence tomography.

[ [ "interferon", "macular edema" ], [ "interferon", "retinopathy" ] ]

In a single practice during the 21 years 1971-1991, the incidence of gestational diabetes in pregnancies in which norethisterone was prescribed was 32.4% (22 of 69) in comparison with 7.1% in pregnancies in which the women did not take norethisterone (137 of 1,684) (p < 0.001).

[ [ "norethisterone", "gestational diabetes" ] ]

Leiomyosarcoma in urinary bladder after cyclophosphamide therapy for retinoblastoma and review of bladder sarcomas.

[ [ "cyclophosphamide", "Leiomyosarcoma" ] ]

A study following large patient groups on theophylline and a combination of theophylline and steroids might clarify the risk of ulcer formation in patients being treated with these medications for asthma.

[ [ "theophylline", "ulcer" ] ]

Inhaled tobramycin solution-associated recurrent eosinophilia and severe persistent bronchospasm in a patient with cystic fibrosis: a case report.

[ [ "tobramycin", "severe persistent bronchospasm" ], [ "tobramycin", "recurrent eosinophilia" ] ]

The hearing impairment and tinnitus were gradually reduced after PTU withdrawal and corticosteroid and azathioprine treatment.

[ [ "PTU", "tinnitus" ], [ "PTU", "hearing impairment" ] ]

We report two patients with infectious mononucleosis-like syndrome induced by salazosulfapyridine (SASP).

[ [ "SASP", "infectious mononucleosis-like syndrome" ], [ "salazosulfapyridine", "infectious mononucleosis-like syndrome" ] ]

Hydroxyurea-induced acute interstitial pneumonitis in a patient with essential thrombocythemia.

[ [ "Hydroxyurea", "acute interstitial pneumonitis" ] ]

Massive plasmocytosis due to methimazole-induced bone marrow toxicity.

[ [ "methimazole", "Massive plasmocytosis" ], [ "methimazole", "bone marrow toxicity" ] ]

The patient expired after seven cycles of treatment had been completed because of pulmonary fibrosis and the drug toxicity of bleomycin.

[ [ "bleomycin", "pulmonary fibrosis" ] ]

Presented is a case story of a woman with classical rheumatoid arthritis, who during introduction of sulphasalazine (SASP) therapy developed a severe and lasting psoriasis-like skin reaction.

[ [ "sulphasalazine", "psoriasis-like skin reaction" ], [ "SASP", "psoriasis-like skin reaction" ] ]

Cefoxitin-associated renal failure.

[ [ "Cefoxitin", "renal failure" ] ]

Baclofen withdrawal syndrome resulting from underdosing of oral baclofen should be considered as a potential source of prolonged fever in the intensive care unit.

[ [ "Baclofen", "withdrawal syndrome" ], [ "baclofen", "withdrawal syndrome" ] ]

Four cases of adverse experiences with clonidine are described.

[ [ "clonidine", "adverse experiences" ] ]

We describe a 10-year-old boy with ulcerative colitis who developed acute pancreatitis while on long-term treatment with 5-aminosalicylic acid.

[ [ "5-aminosalicylic acid", "acute pancreatitis" ] ]

A 50-year-old woman with a history of migraine without aura, predominantly occurring around her menstrual periods, developed a spinal cord lesion following the use of zolmitriptan.

[ [ "zolmitriptan", "spinal cord lesion" ] ]

IV propranolol was used as the initial treatment for his hyperadrenergic state, resulting in a decrease in heart rate but a paroxsymal increase in blood pressure.

[ [ "propranolol", "paroxsymal increase in blood pressure" ], [ "propranolol", "decrease in heart rate" ] ]

Ptosis occurring 24 h after chloroquine therapy, with full recovery 48 h after cessation of chloroquine, has not been described previously.

[ [ "chloroquine", "Ptosis" ] ]

An unusual presentation of spontaneous sub-conjunctival haematoma in a patient receiving warfarin.

[ [ "warfarin", "sub-conjunctival haematoma" ] ]

Here, we present a case of sirolimus-associated interstitial pneumonitis in a cardiac transplant recipient that resolved completely with withdrawal of the drug and treatment with corticosteroids.

[ [ "sirolimus", "interstitial pneumonitis" ] ]

Thirty patients with hepatic reactions to cyclofenil, a non-steroidal drug with a stimulating effect on ovulation, are reviewed.

[ [ "cyclofenil", "hepatic reactions" ] ]

Cutaneous necrosis after injection of polyethylene glycol-modified interferon alfa.

[ [ "interferon alfa", "Cutaneous necrosis" ] ]

From 1996 to 2002 several medications were changed due to their adverse effects: indinavir (renal colic and fever), nelfinavir (cutaneous rash), and efavirenz (nausea and temporary memory loss).

[ [ "indinavir", "renal colic" ], [ "indinavir", "fever" ], [ "nelfinavir", "cutaneous rash" ], [ "efavirenz", "nausea" ], [ "efavirenz", "temporary memory loss" ] ]

In one patient, treatment with DCA was associated with a decrease in blood lactate levels from 11.2 mM before treatment to 0.8 mM 16 h later.

[ [ "DCA", "decrease in blood lactate levels" ] ]

A second possibility is an interaction between clarithromycin and isradipine, potentially increasing the hepatic toxicity of isradipine.

[ [ "isradipine", "increasing the hepatic toxicity" ], [ "clarithromycin", "increasing the hepatic toxicity" ] ]

We describe 2 patients with prior amputation who experienced phantom limb pain (PLP) after receiving paclitaxel therapy.

[ [ "paclitaxel", "phantom limb pain" ], [ "paclitaxel", "PLP" ] ]

Acute dystonia induced by lamivudine.

[ [ "lamivudine", "Acute dystonia" ] ]

Anastrozole-associated sclerosing glomerulonephritis in a patient with breast cancer.

[ [ "Anastrozole", "sclerosing glomerulonephritis" ] ]

Treatment of ELP in children is generally supportive, with the symptoms and roentgenographic abnormalities resolving within months after stopping the use of mineral oil.

[ [ "mineral oil", "roentgenographic abnormalities" ], [ "mineral oil", "ELP" ] ]

Two children with rheumatic fever developed anicteric hepatitis while on high-dose aspirin therapy.

[ [ "aspirin", "anicteric hepatitis" ] ]

Charcoal haemoperfusion and cysteamine therapy led to the rapid removal of the paracetamol from the body and consequently prevented the development of severe hepatic necrosis.

[ [ "paracetamol", "severe hepatic necrosis" ] ]

However, 1 eye had vitreous hemorrhage after repeated injections of tPA.

[ [ "tPA", "vitreous hemorrhage" ] ]

We report an additional case of isotretinoin teratogenicity in which the patient had agenesis of the cerebellar vermis, multiple leptomeningeal neuroglial heterotopias, hydrocephalus, and abnormalities of the corticospinal tracts.

[ [ "isotretinoin", "teratogenicity" ], [ "isotretinoin", "agenesis of the cerebellar vermis" ], [ "isotretinoin", "multiple leptomeningeal neuroglial heterotopias" ], [ "isotretinoin", "hydrocephalus" ], [ "isotretinoin", "abnormalities of the corticospinal tracts" ] ]

Cataracts induced by intermittent Decadron used as an antiemetic.

[ [ "Decadron", "Cataracts" ] ]

Diclofenac-associated hepatitis.

[ [ "Diclofenac", "hepatitis" ] ]

This case study is the second report of localized purpura after prolonged lamotrigine treatment suggesting this may be an atypical lamotrigine-induced drug reaction.

[ [ "lamotrigine", "localized purpura" ] ]

Initial treatment with heparin was substituted with thrombolysis, which resulted in clinical improvement and dissolution of right heart thrombus but was followed by fatal intracerebral haemorrhage.

[ [ "heparin", "fatal intracerebral haemorrhage" ] ]

Atrial fibrillation occurring in a patient taking etanercept plus methotrexate for rheumatoid arthritis.

[ [ "etanercept", "Atrial fibrillation" ], [ "methotrexate", "Atrial fibrillation" ] ]

We describe the case of a nonatopic 17-year-old girl with bronchial asthma and aspirin intolerance who developed a dramatic anaphylactic reaction to oral prednisone.

[ [ "prednisone", "anaphylactic reaction" ] ]

This case demonstrates an occupational activity (construction) that has now become the dominant source of lead exposure for U.S. adults, the importance of a good occupational history to suspecting and making a diagnosis, the possible outcomes of chronic lead toxicity, and the importance of preventing further exposure and using proper methods to treat acute toxicity.

[ [ "lead", "lead toxicity" ] ]

Risperidone-induced psychosis and depression in a child with a mitochondrial disorder.

[ [ "Risperidone", "depression" ], [ "Risperidone", "psychosis" ] ]