harpreetmann/entity_extraction_ade · Datasets at Hugging Face

text stringlengths 22 455	pairs listlengths 1 24
Anaphylaxis from isoniazid is a possible side effect to this commonly prescribed antibiotic.	[ [ "isoniazid", "Anaphylaxis" ] ]
The authors report a case of a patient who received alteplase for acute myocardial infarction and developed spontaneous subfascial hematoma without any evidence of direct trauma.	[ [ "alteplase", "subfascial hematoma" ] ]
CONCLUSION: Squamous metaplasia in these cases appears to be a consequence of progestin therapy.	[ [ "progestin", "Squamous metaplasia" ] ]
In one patient the vasculitis resolved after termination of the ciprofloxacin therapy; in the other patient the ciprofloxacin-induced hemorrhagic vasculitis was superimposed on a severe forefoot infection, leading to progressive gangrene and a below-knee amputation.	[ [ "ciprofloxacin", "below-knee amputation" ], [ "ciprofloxacin", "severe forefoot infection" ], [ "ciprofloxacin", "progressive gangrene" ], [ "ciprofloxacin", "vasculitis" ], [ "ciprofloxacin", "hemorrhagic vasculitis" ] ]
The Naranjo probability scale suggests a highly probable relationship between AIN and pantoprazole therapy in this patient.	[ [ "pantoprazole", "AIN" ] ]
We report on a young adolescent with benign intracranial hypertension which we attribute to the use of minocycline for acne.	[ [ "minocycline", "benign intracranial hypertension" ] ]
We present two cases of nitrofurantoin-induced pulmonary toxicity in which the initial HRCT showed a widespread reticular pattern and associated distortion of the lung parenchyma, thought to represent established fibrosis.	[ [ "nitrofurantoin", "pulmonary toxicity" ], [ "nitrofurantoin", "widespread reticular pattern" ], [ "nitrofurantoin", "distortion of the lung parenchyma" ], [ "nitrofurantoin", "fibrosis" ] ]
A 61-year-old man developed clinical lupus syndrome with positive antinuclear antibody, positive lupus erythematosus (LE) cell preparation, and diffuse proliferative glomerulonephritis following 26 months of procainamide therapy.	[ [ "procainamide", "diffuse proliferative glomerulonephritis" ], [ "procainamide", "clinical lupus syndrome" ], [ "procainamide", "lupus erythematosus" ] ]
This case emphasizes the importance of the evaluation of lithium-associated polyuria with a direct measurement of plasma vasopressin, interpreted with simultaneous plasma and urine osmolality to secure the correct diagnosis and ensure appropriate therapeutic management.	[ [ "lithium", "polyuria" ] ]
This is a case of pseudoephedrine-induced intracerebral hemorrhage in a patient with an underlying vascular malformation.	[ [ "pseudoephedrine", "intracerebral hemorrhage" ] ]
Methemoglobinemia associated with dermal application of benzocaine cream in a cat.	[ [ "benzocaine", "Methemoglobinemia" ] ]
Carbamazepine-related hyponatremia following cardiopulmonary bypass.	[ [ "Carbamazepine", "hyponatremia" ] ]
CONCLUSIONS: It is probable that foscarnet contributed to the electrolyte disorders and symptomatology in this patient.	[ [ "foscarnet", "electrolyte disorders" ] ]
Milk-alkali syndrome induced by 1,25(OH)2D in a patient with hypoparathyroidism.	[ [ "1,25(OH)2D", "Milk-alkali syndrome" ] ]
Risperidone-induced obsessive-compulsive symptoms in two children.	[ [ "Risperidone", "obsessive-compulsive symptoms" ] ]
We report on a patient with subarachnoid haemorrhage who developed an acute life-threatening pseudo-obstruction of the colon, a variant of adynamic ileus, while being treated with intravenous nimodipine.	[ [ "nimodipine", "adynamic ileus" ], [ "nimodipine", "pseudo-obstruction of the colon" ] ]
This patient, who had a history of osteoarthritis, had severe hepatitis 5 weeks after being started on diclofenac for increasing pain in the joints.	[ [ "diclofenac", "hepatitis" ] ]
This report presents a case of colon perforation which occurred 4 months after treatment with intraperitoneal chromic phosphate for stage IB ovarian papillary serous cystadenocarcinoma.	[ [ "chromic phosphate", "colon perforation" ] ]
METHODS: We queried 35 rheumatologists at the Robert Breck Brigham Arthritis Center to determine if weight loss had occurred as an adverse event in patients treated with leflunomide between November 1998 and January 2000.	[ [ "leflunomide", "weight loss" ] ]
This is the first case of hydroxyurea-induced acute interstitial pneumonitis reported in the literature.	[ [ "hydroxyurea", "acute interstitial pneumonitis" ] ]
Choanal atresia and athelia: methimazole teratogenicity or a new syndrome?	[ [ "methimazole", "athelia" ], [ "methimazole", "Choanal atresia" ], [ "methimazole", "teratogenicity" ] ]
She continued to receive regular insulin 4 times per day over the following 3 years with only occasional hives.	[ [ "insulin", "hives" ] ]
The association with prolonged unopposed estrogen-like stimulation with tamoxifen as a possible factor in the development of ovarian endometrioid carcinoma is discussed.	[ [ "tamoxifen", "ovarian endometrioid carcinoma" ] ]
Although visual hallucinations have not been reported as an adverse effect of this agent, we describe three patients who experienced complex visual hallucinations and altered mental status after zonisamide treatment was begun or its dosage increased.	[ [ "zonisamide", "altered mental status" ], [ "zonisamide", "visual hallucinations" ] ]
Reversible valproic acid-induced dementia: a case report.	[ [ "valproic acid", "dementia" ] ]
Severe hepatotoxicity related to benzarone: a report of three cases with two fatalities.	[ [ "benzarone", "Severe hepatotoxicity" ] ]
CONCLUSIONS: We report a typical symptoms of Charles-Bonnet syndrome (CBS) in patients with severe AMD after intravitreal Avastin-injections.	[ [ "Avastin", "CBS" ], [ "Avastin", "Charles-Bonnet syndrome" ] ]
A 52-year-old, white female developed low-grade fever, cough, and dyspnea after 8 weeks treatment with sodium aurothiomalate for rheumatoid arthritis.	[ [ "sodium aurothiomalate", "cough" ], [ "sodium aurothiomalate", "dyspnea" ], [ "sodium aurothiomalate", "low-grade fever" ] ]
Cardiac arrest associated with sulprostone use during caesarean section.	[ [ "sulprostone", "Cardiac arrest" ] ]
Dose-dependent olanzapine-associated leukopenia: three case reports.	[ [ "olanzapine", "leukopenia" ] ]
The authors report a case of focal myocardial necrosis, presenting clinically as an acute myocardial infarction during the administration of the antineoplastic drug, amsacrine, in a patient without coronary artery disease.	[ [ "amsacrine", "acute myocardial infarction" ], [ "amsacrine", "focal myocardial necrosis" ] ]
Incomplete posterior hyaloid detachment after intravitreal pegaptanib injection in diabetic macular edema.	[ [ "pegaptanib", "Incomplete posterior hyaloid detachment" ] ]
Renal failure associated with acetazolamide therapy for glaucoma.	[ [ "acetazolamide", "Renal failure" ] ]
Factors that suggested an association between the severe angioedematous reaction and BP topical application include the strong reaction to BP in the patch-test, the temporal relationship, the complete resolution of symptoms after the drug was withdrawn and the absence of other identified explanations.	[ [ "BP", "severe angioedematous reaction" ] ]
Acute renal failure in a patient receiving treatment with suramin.	[ [ "suramin", "Acute renal failure" ] ]
Since the thrombocyte count started to increase immediately after initiation and dropped immediately after discontinuation of ciprofloxacin and tazobactam/piperacillin and all other drugs were discontinued already before or were started after the nadir of the thrombocyte count, these two antibiotics were regarded causative.	[ [ "piperacillin", "thrombocyte count started to increase" ], [ "ciprofloxacin", "thrombocyte count started to increase" ], [ "tazobactam", "thrombocyte count started to increase" ] ]
We wish to call for cautious approach at time of cessation of prolonged ACTH therapy because of possible unexpected and only partially understood hazardous side effects such as hyperkalemia.	[ [ "ACTH", "hyperkalemia" ] ]
PURPOSE: A case of probable enoxaparin-induced hepatotoxicity is described.	[ [ "enoxaparin", "hepatotoxicity" ] ]
The pathogenic mechanisms involved in the development of adriamycin cardiomyopathy are reviewed, and the possible synergistic effect of other antitumor antibiotics is discussed.	[ [ "adriamycin", "cardiomyopathy" ] ]
This report describes a probable case of infliximab-induced membranous nephropathy.	[ [ "infliximab", "membranous nephropathy" ] ]
We report a case in which hemorrhage occurred in an asymptomatic falx meningioma known beforehand, after the internal use of low-dose aspirin for 16 months.	[ [ "aspirin", "hemorrhage" ] ]
Olanzapine-associated neuroleptic malignant syndrome.	[ [ "Olanzapine", "neuroleptic malignant syndrome" ] ]
Mammary gigantism is a rare complication of D-penicillamine treatment.	[ [ "D-penicillamine", "Mammary gigantism" ] ]
Knowledge regarding potential adverse effects of CAP is paramount and dose modification is indicated with development of neurotoxicity.	[ [ "CAP", "neurotoxicity" ] ]
A small number of oxaliplatin-related hemolytic and/or thrombocytopenic reactions have been reported.	[ [ "oxaliplatin", "hemolytic and/or thrombocytopenic reactions" ] ]
Gabapentin withdrawal presenting as status epilepticus.	[ [ "Gabapentin", "status epilepticus" ] ]
Angio-oedema as an unusual tolerable side effect of voriconazole therapy.	[ [ "voriconazole", "Angio-oedema" ] ]
Atypical neuroleptic malignant syndrome associated with olanzapine.	[ [ "olanzapine", "neuroleptic malignant syndrome" ] ]
A patient developed transient, acute myopia while on isotretinoin (Accutane) therapy for acne.	[ [ "isotretinoin", "acute myopia" ], [ "Accutane", "acute myopia" ] ]
CONCLUSIONS: Prolonged exposure to itraconazole, administered either continuously or intermittently, may precipitate severe and irreversible hepatotoxic events.	[ [ "itraconazole", "severe and irreversible hepatotoxic events" ] ]
This is the first report on the histopathological findings of thyroid tissue from a patient with amiodarone-induced hypothyroidism.	[ [ "amiodarone", "hypothyroidism" ] ]
A 57-year-old woman developed pulmonary sarcoidosis during therapy with interferon beta for advanced renal cell carcinoma metastatic to mediastinal lymph nodes.	[ [ "interferon beta", "pulmonary sarcoidosis" ] ]
Priapism associated with zuclopenthixol.	[ [ "zuclopenthixol", "Priapism" ] ]
Amiodarone-induced dysthyroidism.	[ [ "Amiodarone", "dysthyroidism" ] ]
A case report of the hypersensitivity syndrome occurring in a patient being treated with dapsone for a brown recluse spider bite is presented.	[ [ "dapsone", "hypersensitivity syndrome" ] ]
All-trans retinoic acid-induced focal myositis, synovitis, and mononeuritis.	[ [ "All-trans retinoic acid", "synovitis" ], [ "All-trans retinoic acid", "mononeuritis" ], [ "All-trans retinoic acid", "focal myositis" ] ]
Zolpidem tissue concentrations in a multiple drug related death involving Ambien.	[ [ "Ambien", "death" ], [ "Zolpidem", "death" ] ]
Does the use of insulin in a patient with liver dysfunction increase water retention in the body, i.e. cause insulin oedema?	[ [ "insulin", "oedema" ] ]
We report two adults who received gabapentin (GBP) and subsequently developed behavioural side effects.	[ [ "gabapentin", "behavioural side effects" ], [ "GBP", "behavioural side effects" ] ]
To our knowledge, this is the first report of significant hypotension associated with intravenous valproate in the treatment of status epilepticus in the pediatric population.	[ [ "valproate", "hypotension" ] ]
Neutrophilic eccrine hidradenitis mimicking cutaneous vasculitis in a lupus patient: a complication of cyclophosphamide.	[ [ "cyclophosphamide", "Neutrophilic eccrine hidradenitis" ] ]
Reversible posterior leukoencephalopathy syndrome in systemic lupus erythematosus with thrombocytopenia treated with cyclosporine.	[ [ "cyclosporine", "Reversible posterior leukoencephalopathy syndrome" ] ]
Mean time between initiation of gemcitabine therapy and onset of HUS was 7.4 +/- 3.5 months, or 21.9 +/- 10.9 doses of gemcitabine.	[ [ "gemcitabine", "HUS" ] ]
We describe a patient who presented with bloody diarrhoea after 15 mg meloxicam daily for 10 days for osteoarthritis.	[ [ "meloxicam", "bloody diarrhoea" ] ]
We report a case of exfoliative dermatitis clearly linked to intravenous and intraperitoneal administration of tobramycin.	[ [ "tobramycin", "exfoliative dermatitis" ] ]
Autoimmune thyroid disease is a common side-effect of interferon-alpha (IFN-alpha) treatment of viral hepatitis C.	[ [ "interferon-alpha", "Autoimmune thyroid disease" ], [ "IFN-alpha", "Autoimmune thyroid disease" ] ]
CONCLUSION: Therapy with indapamide may induce diabetes in essential hypertension patients.	[ [ "indapamide", "diabetes" ] ]
Sirolimus-eluting stent thrombosis several years after clopidogrel discontinuation.	[ [ "clopidogrel", "Sirolimus-eluting stent thrombosis" ] ]
Pregabalin-induced cortical negative myoclonus in a patient with neuropathic pain.	[ [ "Pregabalin", "cortical negative myoclonus" ] ]
Hypernatraemia induced by sodium polystyrene sulphonate (Kayexalate) in two extremely low birth weight newborns.	[ [ "Kayexalate", "Hypernatraemia" ], [ "sodium polystyrene sulphonate", "Hypernatraemia" ] ]
The latter form (Macrodantin) is reported to engender less gastrointestinal intolerance but it can produce the same adverse effects as the conventional form--liver damage, acute and chronic pulmonary reactions, peripheral neuropathy, blood dyscrasias and allergic reactions--and does so just as rapidly and floridly; one such case is reported here.	[ [ "Macrodantin", "allergic reactions" ], [ "Macrodantin", "peripheral neuropathy" ], [ "Macrodantin", "acute and chronic pulmonary reactions" ], [ "Macrodantin", "blood dyscrasias" ], [ "Macrodantin", "liver damage" ] ]
We present a depressive patient who developed mild parkinsonian signs and camptocormia after the introduction of olanzapine.	[ [ "olanzapine", "mild parkinsonian signs" ], [ "olanzapine", "camptocormia" ] ]
DESIGN: We reviewed the medical records of four patients, who were seen by us between July 2000 and February 2004 for sudden onset of a central neurological syndrome within days of intrathecal MTX.	[ [ "MTX", "central neurological syndrome" ] ]
Ciprofloxacin is among the standard treatments for infected ischemic ulcers; in the rare case of ciprofloxacin-induced hemorrhagic vasculitis, it might be interpreted as progression of infection, instead of a complication of the treatment, thus leading to faulty diagnosis and treatment.	[ [ "ciprofloxacin", "hemorrhagic vasculitis" ] ]
OBJECTIVE: To report a case of toxin-positive Clostridium difficile-induced colitis (CDIC) after use of clindamycin phosphate vaginal cream.	[ [ "clindamycin phosphate", "toxin-positive Clostridium difficile-induced colitis" ] ]
Multiple mechanisms for ciprofloxacin-induced nephrotoxicity have been proposed.	[ [ "ciprofloxacin", "nephrotoxicity" ] ]
This is the first report of non-convulsive status epilepticus provoked by tiagabine in adolescent patients.	[ [ "tiagabine", "non-convulsive status epilepticus" ] ]
CONCLUSIONS: This is the first report of a possible interaction between propafenone and citalopram, which caused propafenone adverse effects (eg, dizziness, falls) and mimicked coronary artery disease.	[ [ "citalopram", "dizziness" ], [ "propafenone", "coronary artery disease" ], [ "propafenone", "dizziness" ], [ "citalopram", "falls" ], [ "citalopram", "coronary artery disease" ], [ "propafenone", "falls" ] ]
Myocardial ischemia associated with high-dose carmustine infusion.	[ [ "carmustine", "Myocardial ischemia" ] ]
Cicatricial entropion associated with chronic dipivefrin application.	[ [ "dipivefrin", "Cicatricial entropion" ] ]
The goal of this study is to describe three patients diagnosed with migraine and epilepsy (both under control) who evolved into status migrainosus after the introduction of oxcarbazepine (OXC), as part of a switch off from carbamazepine (CBZ).	[ [ "carbamazepine", "status migrainosus" ], [ "oxcarbazepine", "status migrainosus" ], [ "OXC", "status migrainosus" ], [ "CBZ", "status migrainosus" ] ]
METHODS: A 76-year-old woman with primary open-angle glaucoma and no history of ocular surgery developed a choroidal detachment 12 hours after initiation of therapy with dorzolamide eye drops.	[ [ "dorzolamide", "choroidal detachment" ] ]
Two cases are reported of patients who developed a hematologic malignancy several years after intravesical chemotherapy of superficial bladder cancer with etoglucid, doxorubicin, and mitomycin C.	[ [ "doxorubicin", "hematologic malignancy" ], [ "etoglucid", "hematologic malignancy" ], [ "mitomycin C", "hematologic malignancy" ] ]
CONCLUSION: Acetic acid is corrosive and may cause vagina bleeding.	[ [ "Acetic acid", "vagina bleeding" ] ]
Ibuprofen overdose is usually characterized by GI upset, dizziness, and mild sedation.	[ [ "Ibuprofen", "mild sedation" ], [ "Ibuprofen", "dizziness" ], [ "Ibuprofen", "GI upset" ] ]
A 52-year-old Black woman on phenytoin therapy for post-traumatic epilepsy developed transient hemiparesis contralateral to the injury.	[ [ "phenytoin", "transient hemiparesis" ] ]
Like other atypical neuroleptics olanzapine is considered to show a reduced prevalence of extrapyramidal side effects when compared to classical neuroleptic drugs.	[ [ "olanzapine", "extrapyramidal side effects" ] ]
Two of our patients developed TD after 23 months and 34 months of ziprasidone monotherapy, respectively.	[ [ "ziprasidone", "TD" ] ]
We report the case of a 27-year-old Indian woman who developed maculopapular rash and angioedema secondary to carbamazepine administration.	[ [ "carbamazepine", "maculopapular rash" ], [ "carbamazepine", "angioedema" ] ]
Sulfasalazine-induced lung disorder is an extremely rare entity which must be considered in all ulcerative colitis patients while on sulfasalazine therapy, despite the absence of pulmonary symptomatology.	[ [ "Sulfasalazine", "ulcerative colitis" ], [ "sulfasalazine", "ulcerative colitis" ], [ "Sulfasalazine", "lung disorder" ] ]
CONCLUSIONS: The use of fluorouracil treatment with careful monitoring can be considered in a patient with mild allergic reactions to capecitabine.	[ [ "capecitabine", "allergic reactions" ] ]
According to the Naranjo adverse drug reaction probability scale, tigecycline was the probable cause of her acute pancreatitis.	[ [ "tigecycline", "acute pancreatitis" ] ]
In both patients the rippling phenomena worsened with pyridostigmine treatment but markedly improved after immunosuppression with azathioprine.	[ [ "pyridostigmine", "rippling phenomena worsened" ] ]
over the past 3 years there have been several reports of uveitis associated with rifabutin therapy.	[ [ "rifabutin", "uveitis" ] ]
Accordingly, camptocormia is a dose-dependent side effect of valproate.	[ [ "valproate", "camptocormia" ] ]
We report a case of generalized cutaneous sclerosis associated with muscle and oesophageal involvement in a patient exposed to herbicides containing bromocil, diuron and aminotriazole.	[ [ "diuron", "generalized cutaneous sclerosis" ], [ "bromocil", "generalized cutaneous sclerosis" ], [ "aminotriazole", "generalized cutaneous sclerosis" ] ]
A 55-year-old woman presented an episode of acute urticaria and labial angioedema 60 minutes after ingesting 500 mg of cloxacillin for a skin abscess.	[ [ "cloxacillin", "labial angioedema" ], [ "cloxacillin", "acute urticaria" ] ]
Nodular scleritis following alendronate therapy.	[ [ "alendronate", "Nodular scleritis" ] ]
Infliximab-induced lupus in Crohn's disease: a case report.	[ [ "Infliximab", "lupus" ] ]
A 73 year-old patient with Wolff-Parkinson-White syndrome and paroxysmic supraventricular tachycardia developed an acute reversible encephalopathy within 15 days of initiation of flecainide.	[ [ "flecainide", "acute reversible encephalopathy" ] ]

Anaphylaxis from isoniazid is a possible side effect to this commonly prescribed antibiotic.

[ [ "isoniazid", "Anaphylaxis" ] ]

The authors report a case of a patient who received alteplase for acute myocardial infarction and developed spontaneous subfascial hematoma without any evidence of direct trauma.

[ [ "alteplase", "subfascial hematoma" ] ]

CONCLUSION: Squamous metaplasia in these cases appears to be a consequence of progestin therapy.

[ [ "progestin", "Squamous metaplasia" ] ]

In one patient the vasculitis resolved after termination of the ciprofloxacin therapy; in the other patient the ciprofloxacin-induced hemorrhagic vasculitis was superimposed on a severe forefoot infection, leading to progressive gangrene and a below-knee amputation.

[ [ "ciprofloxacin", "below-knee amputation" ], [ "ciprofloxacin", "severe forefoot infection" ], [ "ciprofloxacin", "progressive gangrene" ], [ "ciprofloxacin", "vasculitis" ], [ "ciprofloxacin", "hemorrhagic vasculitis" ] ]

The Naranjo probability scale suggests a highly probable relationship between AIN and pantoprazole therapy in this patient.

[ [ "pantoprazole", "AIN" ] ]

We report on a young adolescent with benign intracranial hypertension which we attribute to the use of minocycline for acne.

[ [ "minocycline", "benign intracranial hypertension" ] ]

We present two cases of nitrofurantoin-induced pulmonary toxicity in which the initial HRCT showed a widespread reticular pattern and associated distortion of the lung parenchyma, thought to represent established fibrosis.

[ [ "nitrofurantoin", "pulmonary toxicity" ], [ "nitrofurantoin", "widespread reticular pattern" ], [ "nitrofurantoin", "distortion of the lung parenchyma" ], [ "nitrofurantoin", "fibrosis" ] ]

A 61-year-old man developed clinical lupus syndrome with positive antinuclear antibody, positive lupus erythematosus (LE) cell preparation, and diffuse proliferative glomerulonephritis following 26 months of procainamide therapy.

[ [ "procainamide", "diffuse proliferative glomerulonephritis" ], [ "procainamide", "clinical lupus syndrome" ], [ "procainamide", "lupus erythematosus" ] ]

This case emphasizes the importance of the evaluation of lithium-associated polyuria with a direct measurement of plasma vasopressin, interpreted with simultaneous plasma and urine osmolality to secure the correct diagnosis and ensure appropriate therapeutic management.

[ [ "lithium", "polyuria" ] ]

This is a case of pseudoephedrine-induced intracerebral hemorrhage in a patient with an underlying vascular malformation.

[ [ "pseudoephedrine", "intracerebral hemorrhage" ] ]

Methemoglobinemia associated with dermal application of benzocaine cream in a cat.

[ [ "benzocaine", "Methemoglobinemia" ] ]

Carbamazepine-related hyponatremia following cardiopulmonary bypass.

[ [ "Carbamazepine", "hyponatremia" ] ]

CONCLUSIONS: It is probable that foscarnet contributed to the electrolyte disorders and symptomatology in this patient.

[ [ "foscarnet", "electrolyte disorders" ] ]

Milk-alkali syndrome induced by 1,25(OH)2D in a patient with hypoparathyroidism.

[ [ "1,25(OH)2D", "Milk-alkali syndrome" ] ]

Risperidone-induced obsessive-compulsive symptoms in two children.

[ [ "Risperidone", "obsessive-compulsive symptoms" ] ]

We report on a patient with subarachnoid haemorrhage who developed an acute life-threatening pseudo-obstruction of the colon, a variant of adynamic ileus, while being treated with intravenous nimodipine.

[ [ "nimodipine", "adynamic ileus" ], [ "nimodipine", "pseudo-obstruction of the colon" ] ]

This patient, who had a history of osteoarthritis, had severe hepatitis 5 weeks after being started on diclofenac for increasing pain in the joints.

[ [ "diclofenac", "hepatitis" ] ]

This report presents a case of colon perforation which occurred 4 months after treatment with intraperitoneal chromic phosphate for stage IB ovarian papillary serous cystadenocarcinoma.

[ [ "chromic phosphate", "colon perforation" ] ]

METHODS: We queried 35 rheumatologists at the Robert Breck Brigham Arthritis Center to determine if weight loss had occurred as an adverse event in patients treated with leflunomide between November 1998 and January 2000.

[ [ "leflunomide", "weight loss" ] ]

This is the first case of hydroxyurea-induced acute interstitial pneumonitis reported in the literature.

[ [ "hydroxyurea", "acute interstitial pneumonitis" ] ]

Choanal atresia and athelia: methimazole teratogenicity or a new syndrome?

[ [ "methimazole", "athelia" ], [ "methimazole", "Choanal atresia" ], [ "methimazole", "teratogenicity" ] ]

She continued to receive regular insulin 4 times per day over the following 3 years with only occasional hives.

[ [ "insulin", "hives" ] ]

The association with prolonged unopposed estrogen-like stimulation with tamoxifen as a possible factor in the development of ovarian endometrioid carcinoma is discussed.

[ [ "tamoxifen", "ovarian endometrioid carcinoma" ] ]

Although visual hallucinations have not been reported as an adverse effect of this agent, we describe three patients who experienced complex visual hallucinations and altered mental status after zonisamide treatment was begun or its dosage increased.

[ [ "zonisamide", "altered mental status" ], [ "zonisamide", "visual hallucinations" ] ]

Reversible valproic acid-induced dementia: a case report.

[ [ "valproic acid", "dementia" ] ]

Severe hepatotoxicity related to benzarone: a report of three cases with two fatalities.

[ [ "benzarone", "Severe hepatotoxicity" ] ]

CONCLUSIONS: We report a typical symptoms of Charles-Bonnet syndrome (CBS) in patients with severe AMD after intravitreal Avastin-injections.

[ [ "Avastin", "CBS" ], [ "Avastin", "Charles-Bonnet syndrome" ] ]

A 52-year-old, white female developed low-grade fever, cough, and dyspnea after 8 weeks treatment with sodium aurothiomalate for rheumatoid arthritis.

[ [ "sodium aurothiomalate", "cough" ], [ "sodium aurothiomalate", "dyspnea" ], [ "sodium aurothiomalate", "low-grade fever" ] ]

Cardiac arrest associated with sulprostone use during caesarean section.

[ [ "sulprostone", "Cardiac arrest" ] ]

Dose-dependent olanzapine-associated leukopenia: three case reports.

[ [ "olanzapine", "leukopenia" ] ]

The authors report a case of focal myocardial necrosis, presenting clinically as an acute myocardial infarction during the administration of the antineoplastic drug, amsacrine, in a patient without coronary artery disease.

[ [ "amsacrine", "acute myocardial infarction" ], [ "amsacrine", "focal myocardial necrosis" ] ]

Incomplete posterior hyaloid detachment after intravitreal pegaptanib injection in diabetic macular edema.

[ [ "pegaptanib", "Incomplete posterior hyaloid detachment" ] ]

Renal failure associated with acetazolamide therapy for glaucoma.

[ [ "acetazolamide", "Renal failure" ] ]

Factors that suggested an association between the severe angioedematous reaction and BP topical application include the strong reaction to BP in the patch-test, the temporal relationship, the complete resolution of symptoms after the drug was withdrawn and the absence of other identified explanations.

[ [ "BP", "severe angioedematous reaction" ] ]

Acute renal failure in a patient receiving treatment with suramin.

[ [ "suramin", "Acute renal failure" ] ]

Since the thrombocyte count started to increase immediately after initiation and dropped immediately after discontinuation of ciprofloxacin and tazobactam/piperacillin and all other drugs were discontinued already before or were started after the nadir of the thrombocyte count, these two antibiotics were regarded causative.

[ [ "piperacillin", "thrombocyte count started to increase" ], [ "ciprofloxacin", "thrombocyte count started to increase" ], [ "tazobactam", "thrombocyte count started to increase" ] ]

We wish to call for cautious approach at time of cessation of prolonged ACTH therapy because of possible unexpected and only partially understood hazardous side effects such as hyperkalemia.

[ [ "ACTH", "hyperkalemia" ] ]

PURPOSE: A case of probable enoxaparin-induced hepatotoxicity is described.

[ [ "enoxaparin", "hepatotoxicity" ] ]

The pathogenic mechanisms involved in the development of adriamycin cardiomyopathy are reviewed, and the possible synergistic effect of other antitumor antibiotics is discussed.

[ [ "adriamycin", "cardiomyopathy" ] ]

This report describes a probable case of infliximab-induced membranous nephropathy.

[ [ "infliximab", "membranous nephropathy" ] ]

We report a case in which hemorrhage occurred in an asymptomatic falx meningioma known beforehand, after the internal use of low-dose aspirin for 16 months.

[ [ "aspirin", "hemorrhage" ] ]

Olanzapine-associated neuroleptic malignant syndrome.

[ [ "Olanzapine", "neuroleptic malignant syndrome" ] ]

Mammary gigantism is a rare complication of D-penicillamine treatment.

[ [ "D-penicillamine", "Mammary gigantism" ] ]

Knowledge regarding potential adverse effects of CAP is paramount and dose modification is indicated with development of neurotoxicity.

[ [ "CAP", "neurotoxicity" ] ]

A small number of oxaliplatin-related hemolytic and/or thrombocytopenic reactions have been reported.

[ [ "oxaliplatin", "hemolytic and/or thrombocytopenic reactions" ] ]

Gabapentin withdrawal presenting as status epilepticus.

[ [ "Gabapentin", "status epilepticus" ] ]

Angio-oedema as an unusual tolerable side effect of voriconazole therapy.

[ [ "voriconazole", "Angio-oedema" ] ]

Atypical neuroleptic malignant syndrome associated with olanzapine.

[ [ "olanzapine", "neuroleptic malignant syndrome" ] ]

A patient developed transient, acute myopia while on isotretinoin (Accutane) therapy for acne.

[ [ "isotretinoin", "acute myopia" ], [ "Accutane", "acute myopia" ] ]

CONCLUSIONS: Prolonged exposure to itraconazole, administered either continuously or intermittently, may precipitate severe and irreversible hepatotoxic events.

[ [ "itraconazole", "severe and irreversible hepatotoxic events" ] ]

This is the first report on the histopathological findings of thyroid tissue from a patient with amiodarone-induced hypothyroidism.

[ [ "amiodarone", "hypothyroidism" ] ]

A 57-year-old woman developed pulmonary sarcoidosis during therapy with interferon beta for advanced renal cell carcinoma metastatic to mediastinal lymph nodes.

[ [ "interferon beta", "pulmonary sarcoidosis" ] ]

Priapism associated with zuclopenthixol.

[ [ "zuclopenthixol", "Priapism" ] ]

Amiodarone-induced dysthyroidism.

[ [ "Amiodarone", "dysthyroidism" ] ]

A case report of the hypersensitivity syndrome occurring in a patient being treated with dapsone for a brown recluse spider bite is presented.

[ [ "dapsone", "hypersensitivity syndrome" ] ]

All-trans retinoic acid-induced focal myositis, synovitis, and mononeuritis.

[ [ "All-trans retinoic acid", "synovitis" ], [ "All-trans retinoic acid", "mononeuritis" ], [ "All-trans retinoic acid", "focal myositis" ] ]

Zolpidem tissue concentrations in a multiple drug related death involving Ambien.

[ [ "Ambien", "death" ], [ "Zolpidem", "death" ] ]

Does the use of insulin in a patient with liver dysfunction increase water retention in the body, i.e. cause insulin oedema?

[ [ "insulin", "oedema" ] ]

We report two adults who received gabapentin (GBP) and subsequently developed behavioural side effects.

[ [ "gabapentin", "behavioural side effects" ], [ "GBP", "behavioural side effects" ] ]

To our knowledge, this is the first report of significant hypotension associated with intravenous valproate in the treatment of status epilepticus in the pediatric population.

[ [ "valproate", "hypotension" ] ]

Neutrophilic eccrine hidradenitis mimicking cutaneous vasculitis in a lupus patient: a complication of cyclophosphamide.

[ [ "cyclophosphamide", "Neutrophilic eccrine hidradenitis" ] ]

Reversible posterior leukoencephalopathy syndrome in systemic lupus erythematosus with thrombocytopenia treated with cyclosporine.

[ [ "cyclosporine", "Reversible posterior leukoencephalopathy syndrome" ] ]

Mean time between initiation of gemcitabine therapy and onset of HUS was 7.4 +/- 3.5 months, or 21.9 +/- 10.9 doses of gemcitabine.

[ [ "gemcitabine", "HUS" ] ]

We describe a patient who presented with bloody diarrhoea after 15 mg meloxicam daily for 10 days for osteoarthritis.

[ [ "meloxicam", "bloody diarrhoea" ] ]

We report a case of exfoliative dermatitis clearly linked to intravenous and intraperitoneal administration of tobramycin.

[ [ "tobramycin", "exfoliative dermatitis" ] ]

Autoimmune thyroid disease is a common side-effect of interferon-alpha (IFN-alpha) treatment of viral hepatitis C.

[ [ "interferon-alpha", "Autoimmune thyroid disease" ], [ "IFN-alpha", "Autoimmune thyroid disease" ] ]

CONCLUSION: Therapy with indapamide may induce diabetes in essential hypertension patients.

[ [ "indapamide", "diabetes" ] ]

Sirolimus-eluting stent thrombosis several years after clopidogrel discontinuation.

[ [ "clopidogrel", "Sirolimus-eluting stent thrombosis" ] ]

Pregabalin-induced cortical negative myoclonus in a patient with neuropathic pain.

[ [ "Pregabalin", "cortical negative myoclonus" ] ]

Hypernatraemia induced by sodium polystyrene sulphonate (Kayexalate) in two extremely low birth weight newborns.

[ [ "Kayexalate", "Hypernatraemia" ], [ "sodium polystyrene sulphonate", "Hypernatraemia" ] ]

The latter form (Macrodantin) is reported to engender less gastrointestinal intolerance but it can produce the same adverse effects as the conventional form--liver damage, acute and chronic pulmonary reactions, peripheral neuropathy, blood dyscrasias and allergic reactions--and does so just as rapidly and floridly; one such case is reported here.

[ [ "Macrodantin", "allergic reactions" ], [ "Macrodantin", "peripheral neuropathy" ], [ "Macrodantin", "acute and chronic pulmonary reactions" ], [ "Macrodantin", "blood dyscrasias" ], [ "Macrodantin", "liver damage" ] ]

We present a depressive patient who developed mild parkinsonian signs and camptocormia after the introduction of olanzapine.

[ [ "olanzapine", "mild parkinsonian signs" ], [ "olanzapine", "camptocormia" ] ]

DESIGN: We reviewed the medical records of four patients, who were seen by us between July 2000 and February 2004 for sudden onset of a central neurological syndrome within days of intrathecal MTX.

[ [ "MTX", "central neurological syndrome" ] ]

Ciprofloxacin is among the standard treatments for infected ischemic ulcers; in the rare case of ciprofloxacin-induced hemorrhagic vasculitis, it might be interpreted as progression of infection, instead of a complication of the treatment, thus leading to faulty diagnosis and treatment.

[ [ "ciprofloxacin", "hemorrhagic vasculitis" ] ]

OBJECTIVE: To report a case of toxin-positive Clostridium difficile-induced colitis (CDIC) after use of clindamycin phosphate vaginal cream.

[ [ "clindamycin phosphate", "toxin-positive Clostridium difficile-induced colitis" ] ]

Multiple mechanisms for ciprofloxacin-induced nephrotoxicity have been proposed.

[ [ "ciprofloxacin", "nephrotoxicity" ] ]

This is the first report of non-convulsive status epilepticus provoked by tiagabine in adolescent patients.

[ [ "tiagabine", "non-convulsive status epilepticus" ] ]

CONCLUSIONS: This is the first report of a possible interaction between propafenone and citalopram, which caused propafenone adverse effects (eg, dizziness, falls) and mimicked coronary artery disease.

[ [ "citalopram", "dizziness" ], [ "propafenone", "coronary artery disease" ], [ "propafenone", "dizziness" ], [ "citalopram", "falls" ], [ "citalopram", "coronary artery disease" ], [ "propafenone", "falls" ] ]

Myocardial ischemia associated with high-dose carmustine infusion.

[ [ "carmustine", "Myocardial ischemia" ] ]

Cicatricial entropion associated with chronic dipivefrin application.

[ [ "dipivefrin", "Cicatricial entropion" ] ]

The goal of this study is to describe three patients diagnosed with migraine and epilepsy (both under control) who evolved into status migrainosus after the introduction of oxcarbazepine (OXC), as part of a switch off from carbamazepine (CBZ).

[ [ "carbamazepine", "status migrainosus" ], [ "oxcarbazepine", "status migrainosus" ], [ "OXC", "status migrainosus" ], [ "CBZ", "status migrainosus" ] ]

METHODS: A 76-year-old woman with primary open-angle glaucoma and no history of ocular surgery developed a choroidal detachment 12 hours after initiation of therapy with dorzolamide eye drops.

[ [ "dorzolamide", "choroidal detachment" ] ]

Two cases are reported of patients who developed a hematologic malignancy several years after intravesical chemotherapy of superficial bladder cancer with etoglucid, doxorubicin, and mitomycin C.

[ [ "doxorubicin", "hematologic malignancy" ], [ "etoglucid", "hematologic malignancy" ], [ "mitomycin C", "hematologic malignancy" ] ]

CONCLUSION: Acetic acid is corrosive and may cause vagina bleeding.

[ [ "Acetic acid", "vagina bleeding" ] ]

Ibuprofen overdose is usually characterized by GI upset, dizziness, and mild sedation.

[ [ "Ibuprofen", "mild sedation" ], [ "Ibuprofen", "dizziness" ], [ "Ibuprofen", "GI upset" ] ]

A 52-year-old Black woman on phenytoin therapy for post-traumatic epilepsy developed transient hemiparesis contralateral to the injury.

[ [ "phenytoin", "transient hemiparesis" ] ]

Like other atypical neuroleptics olanzapine is considered to show a reduced prevalence of extrapyramidal side effects when compared to classical neuroleptic drugs.

[ [ "olanzapine", "extrapyramidal side effects" ] ]

Two of our patients developed TD after 23 months and 34 months of ziprasidone monotherapy, respectively.

[ [ "ziprasidone", "TD" ] ]

We report the case of a 27-year-old Indian woman who developed maculopapular rash and angioedema secondary to carbamazepine administration.

[ [ "carbamazepine", "maculopapular rash" ], [ "carbamazepine", "angioedema" ] ]

Sulfasalazine-induced lung disorder is an extremely rare entity which must be considered in all ulcerative colitis patients while on sulfasalazine therapy, despite the absence of pulmonary symptomatology.

[ [ "Sulfasalazine", "ulcerative colitis" ], [ "sulfasalazine", "ulcerative colitis" ], [ "Sulfasalazine", "lung disorder" ] ]

CONCLUSIONS: The use of fluorouracil treatment with careful monitoring can be considered in a patient with mild allergic reactions to capecitabine.

[ [ "capecitabine", "allergic reactions" ] ]

According to the Naranjo adverse drug reaction probability scale, tigecycline was the probable cause of her acute pancreatitis.

[ [ "tigecycline", "acute pancreatitis" ] ]

In both patients the rippling phenomena worsened with pyridostigmine treatment but markedly improved after immunosuppression with azathioprine.

[ [ "pyridostigmine", "rippling phenomena worsened" ] ]

over the past 3 years there have been several reports of uveitis associated with rifabutin therapy.

[ [ "rifabutin", "uveitis" ] ]

Accordingly, camptocormia is a dose-dependent side effect of valproate.

[ [ "valproate", "camptocormia" ] ]

We report a case of generalized cutaneous sclerosis associated with muscle and oesophageal involvement in a patient exposed to herbicides containing bromocil, diuron and aminotriazole.

[ [ "diuron", "generalized cutaneous sclerosis" ], [ "bromocil", "generalized cutaneous sclerosis" ], [ "aminotriazole", "generalized cutaneous sclerosis" ] ]

A 55-year-old woman presented an episode of acute urticaria and labial angioedema 60 minutes after ingesting 500 mg of cloxacillin for a skin abscess.

[ [ "cloxacillin", "labial angioedema" ], [ "cloxacillin", "acute urticaria" ] ]

Nodular scleritis following alendronate therapy.

[ [ "alendronate", "Nodular scleritis" ] ]

Infliximab-induced lupus in Crohn's disease: a case report.

[ [ "Infliximab", "lupus" ] ]

A 73 year-old patient with Wolff-Parkinson-White syndrome and paroxysmic supraventricular tachycardia developed an acute reversible encephalopathy within 15 days of initiation of flecainide.

[ [ "flecainide", "acute reversible encephalopathy" ] ]