harpreetmann/entity_extraction_ade · Datasets at Hugging Face

text stringlengths 22 455	pairs listlengths 1 24
Case study: adverse response to clonidine.	[ [ "clonidine", "adverse response" ] ]
The authors report two cases of delayed elimination of methotrexate in patients receiving ciprofloxacin, with severe toxicity.	[ [ "methotrexate", "delayed elimination" ], [ "ciprofloxacin", "toxicity" ], [ "ciprofloxacin", "delayed elimination" ] ]
Tubulointerstitial nephritis induced by the leukotriene receptor antagonist pranlukast.	[ [ "pranlukast", "Tubulointerstitial nephritis" ] ]
Alprazolam-induced mania: two clinical cases.	[ [ "Alprazolam", "mania" ] ]
Hepatotoxicity associated with use of D-penicillamine in rheumatoid arthritis.	[ [ "D-penicillamine", "Hepatotoxicity" ] ]
We report two new cases of sarcoidosis in two patients with hepatitis C virus infection treated with interferon alfa and ribavirin.	[ [ "interferon alfa", "sarcoidosis" ], [ "ribavirin", "sarcoidosis" ] ]
Behavioral side effects associated with clonazepam may include agitation, aggression, hyperactivity, irritability, property destruction, and temper tantrums.	[ [ "clonazepam", "hyperactivity" ], [ "clonazepam", "irritability" ], [ "clonazepam", "agitation" ], [ "clonazepam", "property destruction" ], [ "clonazepam", "temper tantrums" ], [ "clonazepam", "aggression" ] ]
Ciprofloxacin is one drug that has been reported to cause interstitial nephritis.	[ [ "Ciprofloxacin", "interstitial nephritis" ] ]
This latest (third) report suggests that the safety profile should be reexamined and at least raises the question of potential renal toxicity of interferons in MS.	[ [ "interferons", "renal toxicity" ] ]
There are major side effects of anastrozole including decrease in both lumbar spine and total hip bone mineral density, increase in the incidence of all bone fractures (especially fractures of spine, hip and wrist), joint disorders and increase in the cholesterol level.	[ [ "anastrozole", "decrease in both lumbar spine" ], [ "anastrozole", "increase in the incidence of all bone fractures" ], [ "anastrozole", "increase in the cholesterol level" ], [ "anastrozole", "joint disorders" ] ]
Renal damage associated with long term use of lithium carbonate.	[ [ "lithium carbonate", "Renal damage" ] ]
RESULTS: Replacing valproate with lamotrigine resulted in a decrease in serum testosterone concentrations in all 3 women.	[ [ "valproate", "serum testosterone" ] ]
Physicians should be aware of the risk of severe AIHA in CLL patients with a history of AIHA or positivation of the DAT during previous fludarabine administration, or in case of secondary fixation of complement to the red cell membrane occurring during fludarabine treatment.	[ [ "fludarabine", "positivation of the DAT" ], [ "fludarabine", "AIHA" ] ]
We present the cases of two female patients diagnosed with relapsing-remitting multiple sclerosis (RRMS) who developed inflammatory musculoskeletal manifestations, following IFN-beta therapy.	[ [ "IFN-beta", "inflammatory musculoskeletal manifestations" ] ]
While both amiodarone and digoxin can cause permanent visual changes, the ocular effects are often reversible.	[ [ "digoxin", "ocular effects" ], [ "digoxin", "visual changes" ], [ "amiodarone", "ocular effects" ], [ "amiodarone", "visual changes" ] ]
The fourth patient showed RLS symptoms that were initially caused by a 20-mg daily olanzapine dosage and were later mitigated when olanzapine was reduced and ropinirole was administered.	[ [ "olanzapine", "RLS symptoms" ] ]
Drug induced liver injury secondary to interferon-beta (IFN-beta) in multiple sclerosis.	[ [ "IFN-beta", "liver injury" ], [ "interferon-beta", "liver injury" ] ]
This case suggests that acyclovir when given intravenously in doses of 10 mg/kg may result in increased serum lithium concentrations.	[ [ "lithium", "increased serum lithium" ], [ "acyclovir", "increased serum lithium" ] ]
Seven of the eight cases of acute leukemia occurred in a series of 553 patients treated with Treosulfan for ovarian cancer in the period from 1970 to 1977 and followed closely for a total of 1159 patient-years up to February 1978.	[ [ "Treosulfan", "acute leukemia" ] ]
The major side effect of infliximab is infection.	[ [ "infliximab", "infection" ] ]
We report a case of a patient with ciprofloxacin-induced SJS and acute onset of VBDS, and reviewed the related literature.	[ [ "ciprofloxacin", "SJS" ], [ "ciprofloxacin", "VBDS" ] ]
The fever abated promptly following discontinuation of acyclovir, and radiographic abnormalities resolved over ten days.	[ [ "acyclovir", "fever" ] ]
The authors describe a patient with hemiparesis who developed the syndrome of irreversible lithium-effectuated neurotoxicity (SILENT) while being treated with lithium for a manic episode.	[ [ "lithium", "neurotoxicity" ] ]
Hemolytic uremic syndrome following the infusion of oxaliplatin: case report.	[ [ "oxaliplatin", "Hemolytic uremic syndrome" ] ]
PURPOSE: To report a case of traumatic flap dehiscence and Enterobacter keratitis 34 months after LASIK.	[ [ "LASIK", "traumatic flap dehiscence" ], [ "LASIK", "Enterobacter keratitis" ] ]
A 33-year-old man with a history of recreational benztropine abuse presented to the emergency department with confusion, abdominal pain, and distention.	[ [ "benztropine", "confusion" ], [ "benztropine", "abdominal pain" ], [ "benztropine", "distention" ] ]
The authors presented a case of pulmonary hypertension during lithium therapy, while she has been on lithium for 6 years.	[ [ "lithium", "pulmonary hypertension" ] ]
Phantom limb pain as a manifestation of paclitaxel neurotoxicity.	[ [ "paclitaxel", "Phantom limb pain" ], [ "paclitaxel", "neurotoxicity" ] ]
Myasthenic patients receiving ampicillin should be closely monitored for possible acute exacerbations.	[ [ "ampicillin", "acute exacerbations" ] ]
Acute nitrite toxicity results from industrial exposure, accidental ingestion (e.g., abuse of organic nitrites as an aphrodisiac, especially in the male homosexual population), and suicidal ingestion.	[ [ "nitrite", "nitrite toxicity" ] ]
Verapamil is widely used for the termination of paroxysmal supraventricular tachycardia (PSVT) with little proarrhythmic effect.	[ [ "Verapamil", "proarrhythmic effect" ] ]
Fatal eosinophilia myalgia syndrome in a marrow transplant patient attributed to total parenteral nutrition with a solution containing tryptophan.	[ [ "tryptophan", "Fatal eosinophilia myalgia syndrome" ] ]
Warfarin-induced skin necrosis and heparin-induced thrombocytopenia following mitral valve replacement for marantic endocarditis.	[ [ "Warfarin", "skin necrosis" ], [ "heparin", "thrombocytopenia" ] ]
In this case report, we have described a patient with Crohn's disease who developed subfulminant hepatitis B after the fourth infusion of infliximab due to an unrecognized HBs-antigen carrier state.	[ [ "infliximab", "subfulminant hepatitis B" ] ]
CASE REPORT: We report a case of intracerebral hemorrhage occurring in a middle-aged man who suffered from chronic sinusitis and had been ingesting pseudoephedrine daily for one year.	[ [ "pseudoephedrine", "intracerebral hemorrhage" ] ]
We describe a life threatening side effect of acute epoprostenol infusion (pulmonary edema) in a patient with pulmonary hypertension associated with limited scleroderma and discuss its management and potential etiology.	[ [ "epoprostenol", "pulmonary edema" ] ]
A case of a 53-year-old man who developed acute pneumonitis after bleomycin and moderate oxygen administration is presented.	[ [ "oxygen", "acute pneumonitis" ], [ "bleomycin", "acute pneumonitis" ] ]
Ciprofloxacin-induced toxic epidermal necrolysis in a patient with systemic lupus erythematosus.	[ [ "Ciprofloxacin", "toxic epidermal necrolysis" ] ]
We describe six patients who developed tardive dyskinesia after treatment with sulpiride for depression or gastrointestinal symptoms.	[ [ "sulpiride", "tardive dyskinesia" ] ]
Patients treated with L-asparaginase may present with hemorrhagic and thrombotic cerebrovascular events.	[ [ "L-asparaginase", "hemorrhagic" ], [ "L-asparaginase", "thrombotic cerebrovascular events" ] ]
Hemodialysis should be performed for rapid reversal of mannitol-induced ARF.	[ [ "mannitol", "ARF" ] ]
ADH hypersecretion in relation to plasma osmolality was reversed by mizoribin withdrawal, suggesting that bredinin might adversely induce SIADH.	[ [ "bredinin", "SIADH" ], [ "mizoribin", "ADH hypersecretion" ] ]
It should be emphasized that the recurrence of nephrotic syndrome was observed after the following chemotherapy, including M-CSF, whereas the bone marrow still remained completely remitted.	[ [ "M-CSF", "nephrotic syndrome" ] ]
Sweet's syndrome is an acute febrile neutrophilic dermatosis that is a known complication of the administration of filgrastim, a drug that causes increased neutrophil proliferation and differentiation.	[ [ "filgrastim", "acute febrile neutrophilic dermatosis" ], [ "filgrastim", "Sweet's syndrome" ] ]
Bisphosphonate-related osteonecrosis of the skull base.	[ [ "Bisphosphonate", "osteonecrosis of the skull base" ] ]
To treat hepatitis B, interferon alpha was administered until the proximal muscle weakness developed.	[ [ "interferon alpha", "muscle weakness" ] ]
Gangrene of the fingertips after bleomycin and methotrexate.	[ [ "bleomycin", "Gangrene" ], [ "methotrexate", "Gangrene" ] ]
Hepatotoxicity resolved once erlotinib was discontinued and serum transaminases returned to baseline normal values.	[ [ "erlotinib", "Hepatotoxicity" ] ]
There are now reports of liver failure following treatment of childhood cancers with AMD.	[ [ "AMD", "liver failure" ] ]
The multiple comedones and ruptured epidermoid cysts are newly reported adverse effects of imiquimod therapy.	[ [ "imiquimod", "multiple comedones" ], [ "imiquimod", "ruptured epidermoid cysts" ] ]
The authors report two cases of acute dystonic reactions (ADRs) as a side effect of lamivudine.	[ [ "lamivudine", "acute dystonic reactions" ], [ "lamivudine", "ADRs" ] ]
Administration of lamotrigine, especially in combination with valproic acid, may lead to the development of TEN.	[ [ "lamotrigine", "TEN" ], [ "valproic acid", "TEN" ] ]
Despite the known pulmonary side effects of nitrofurantoin, there is no report of this toxicity occurring in pregnant patients.	[ [ "nitrofurantoin", "pulmonary side effects" ] ]
Despite a response of the meningeal tumor the patient developed in the third week of MTX treatment a progressive visual loss and loss of consciousness which worsened during subsequent Ara-C treatment and led to death within 3 weeks.	[ [ "MTX", "progressive visual loss" ], [ "MTX", "death" ], [ "Ara-C", "death" ], [ "Ara-C", "loss of consciousness" ], [ "MTX", "loss of consciousness" ], [ "Ara-C", "progressive visual loss" ] ]
A boy with chronic neutropenia and recurrent inflammatory skin lesions developed multiple erythematous nodules following administration of G-CSF.	[ [ "G-CSF", "multiple erythematous nodules" ] ]
Infections are a major adverse effect during the treatment with anti-TNF-alpha.	[ [ "anti-TNF-alpha", "Infections" ] ]
We report a case admitted with a first-detected, symptomatic paroxysmal atrial fibrillation in a healthy patient after self-medication with vardenafil.	[ [ "vardenafil", "symptomatic paroxysmal atrial fibrillation" ] ]
Rapamycin/sirolimus-induced pneumonitis has been described previously in renal transplant recipients, and this report describes a stable heart-lung transplant recipient who developed a pulmonary infiltrate that reversed after ceasing SR therapy.	[ [ "Rapamycin", "pulmonary infiltrate" ], [ "SR", "pulmonary infiltrate" ], [ "sirolimus", "pulmonary infiltrate" ], [ "Rapamycin", "pneumonitis" ], [ "sirolimus", "pneumonitis" ] ]
Neuroleptic malignant syndrome in an adolescent receiving olanzapine-lithium combination therapy.	[ [ "lithium", "Neuroleptic malignant syndrome" ], [ "olanzapine", "Neuroleptic malignant syndrome" ] ]
Haemolytic-uraemic syndrome complicating long-term mitomycin C and 5-fluorouracil therapy for gastric carcinoma.	[ [ "mitomycin C", "Haemolytic-uraemic syndrome" ], [ "5-fluorouracil", "Haemolytic-uraemic syndrome" ] ]
Sulfadiazine crystalluria revisited.	[ [ "Sulfadiazine", "crystalluria" ] ]
CONCLUSIONS: This study confirmed that in most patients MTX-induced liver cirrhosis is not aggressive.	[ [ "MTX", "liver cirrhosis" ] ]
This report describes a case of paradoxical, intravenous valproic acid-induced seizure exacerbation in a child with juvenile absence epilepsy, documented by video-electroencephalography.	[ [ "valproic acid", "seizure exacerbation" ], [ "paradoxical", "seizure exacerbation" ] ]
Salicylate hepato toxicity in rheumatic fever.	[ [ "Salicylate", "hepato toxicity" ] ]
She developed a generalized rash and itching, sore throat, and dizziness approximately 4 hours after the first dose of capecitabine.	[ [ "capecitabine", "dizziness" ], [ "capecitabine", "sore throat" ], [ "capecitabine", "generalized rash" ], [ "capecitabine", "itching" ] ]
We describe a case of pneumonitis following local administration of methotrexate for nonsurgical termination of an ectopic pregnancy.	[ [ "methotrexate", "pneumonitis" ] ]
Halothane hepatitis and prompt resolution with methionine therapy: case report.	[ [ "Halothane", "hepatitis" ] ]
Oculomotor disturbances associated with 5-fluorouracil chemotherapy.	[ [ "5-fluorouracil", "Oculomotor disturbances" ] ]
Since early symptoms of the toxic effects of theophylline can mimic peptic ulcer disease, cimetidine might be prescribed for the gastrointestinal symptoms with subsequent worsening of theophylline poisoning.	[ [ "theophylline", "peptic ulcer disease" ] ]
Its overall toxicity is considerably less compared to standard induction chemotherapy; however, it is associated with a high incidence of a potentially fatal symptom complex referred to as "retinoic acid syndrome." This report describes a patient with APL who developed the syndrome a few weeks after initiating induction therapy with ATRA despite being treated for hyperleukocytosis.	[ [ "retinoic acid", "potentially fatal symptom" ], [ "retinoic acid", "retinoic acid syndrome" ], [ "retinoic acid", "toxicity" ] ]
These case reports provide evidence that 5-aminosalicylic acid may induce acute pancreatitis after long term treatment.	[ [ "5-aminosalicylic acid", "acute pancreatitis" ] ]
OBJECTIVE: We report a case of cutaneous KS lesions in a patient affected by CML treated with imatinib.	[ [ "imatinib", "cutaneous KS lesions" ] ]
Severe rhabdomyolysis following massive ingestion of oolong tea: caffeine intoxication with coexisting hyponatremia.	[ [ "oolong tea", "rhabdomyolysis" ], [ "caffeine", "caffeine intoxication" ], [ "caffeine", "rhabdomyolysis" ], [ "oolong tea", "caffeine intoxication" ] ]
Acute myeloid leukemia and lung cancer occurring in a chronic lymphocytic leukemia patient treated with fludarabine and autologous peripheral blood stem-cell transplantation.	[ [ "fludarabine", "Acute myeloid leukemia" ], [ "fludarabine", "lung cancer" ] ]
Ritonavir acted as a CYP3A4 inhibitor, diminishing carbamazepine metabolism and provoking an increase in serum levels and clinical toxicity.	[ [ "Ritonavir", "clinical toxicity" ], [ "Ritonavir", "diminishing carbamazepine metabolism" ], [ "Ritonavir", "increase in serum levels" ] ]
Isotretinoin teratogenicity.	[ [ "Isotretinoin", "teratogenicity" ] ]
Thrombotic stroke associated with the use of porcine factor VIII in a patient with acquired haemophilia.	[ [ "porcine factor VIII", "Thrombotic stroke" ] ]
To our knowledge, this is the first report of an angio-oedema associated with VRC.	[ [ "VRC", "angio-oedema" ] ]
Cholesterol crystal embolization-associated renal failure after therapy with recombinant tissue-type plasminogen activator.	[ [ "tissue-type plasminogen activator", "Cholesterol crystal embolization" ], [ "tissue-type plasminogen activator", "renal failure" ] ]
However, one patient exhibited severe hypersensitivity reactions including cardiac arrest and apnea, and another four patients developed eruptions, hypotension, and tachycardia soon after administration of CBDCA.	[ [ "CBDCA", "tachycardia" ], [ "CBDCA", "eruptions" ], [ "CBDCA", "apnea" ], [ "CBDCA", "severe hypersensitivity reactions" ], [ "CBDCA", "cardiac arrest" ], [ "CBDCA", "hypotension" ] ]
Use of the Naranjo adverse drug reaction probability scale indicated a probable relationship (score of 5) between the patient's development of hepatotoxicity and the TMP-SMX therapy.	[ [ "TMP-SMX", "hepatotoxicity" ] ]
On the second day of hospitalization, it was noted that the patient's dyspnea and sinus bradycardia could be related to a recent increase in his timolol dosage.	[ [ "timolol", "dyspnea" ], [ "timolol", "sinus bradycardia" ] ]
The current report describes a man who was prescribed zonisamide for epilepsy and subsequently developed widespread skin rash, acute kidney injury, high-grade fever, eosinophilia, liver dysfunction, lymphadenopathy and an increase in antihuman herpesvirus-6 immunoglobulin G titer.	[ [ "zonisamide", "acute kidney injury" ], [ "zonisamide", "high-grade fever" ], [ "zonisamide", "eosinophilia" ], [ "zonisamide", "liver dysfunction" ], [ "zonisamide", "skin rash" ], [ "zonisamide", "lymphadenopathy" ], [ "zonisamide", "an increase in antihuman herpesvirus-6 immunoglobulin G titer" ] ]
A potential role for renal and hepatic impairment in the observed protracted course of amiodarone-induced thyrotoxicosis is suggested.	[ [ "amiodarone", "thyrotoxicosis" ] ]
DISCUSSION: This case shows that switching to zidovudine potentially can lead to a hyperlactatemia relapse.	[ [ "zidovudine", "hyperlactatemia relapse" ] ]
We report a case of 48-year-old woman with seizure disorder on divalproex sodium (Depakote) who presented with dyspnea.	[ [ "Depakote", "dyspnea" ], [ "divalproex sodium", "dyspnea" ] ]
This case report illustrates the neurotoxicity unique to HDARAC.	[ [ "HDARAC", "neurotoxicity" ] ]
OBJECTIVE: To report on the possible development of serotonin syndrome in a patient receiving clomipramine after clozapine was withdrawn from the treatment regimen.	[ [ "clomipramine", "serotonin syndrome" ], [ "clozapine", "serotonin syndrome" ] ]
CASES: Two postmenopausal women treated with tamoxifen and progestational agents for breast carcinoma developed uterine enlargement and intermittent spotting.	[ [ "tamoxifen", "uterine enlargement" ], [ "tamoxifen", "intermittent spotting" ] ]
Motor fluctuations appear after 2-3 years of levodopa treatment, and affect at least 50% of patients after five years.	[ [ "levodopa", "Motor fluctuations" ] ]
Although the t-AML developed following oral etoposide therapy, the child had previously received high-dose, multiagent chemotherapy, and rearrangement of the MLL gene was not demonstrated.	[ [ "etoposide", "t-AML" ] ]
Recurrent palmar-plantar erythrodysaesthesia following high-dose cytarabine treatment for acute lymphoblastic leukemia.	[ [ "cytarabine", "palmar-plantar erythrodysaesthesia" ] ]
Troglitazone-induced fulminant hepatic failure.	[ [ "Troglitazone", "fulminant hepatic failure" ] ]
Pentazocine-induced fibrous myopathy and localized neuropathy.	[ [ "Pentazocine", "fibrous myopathy" ], [ "Pentazocine", "neuropathy" ] ]
We report four cases of encephalopathy coincident with elevated aluminum levels as well as one patient who developed seizures while receiving continuous bladder irrigations with alum.	[ [ "alum", "seizures" ], [ "alum", "elevated aluminum levels" ], [ "alum", "encephalopathy" ] ]
The case of a patient with infectious mononucleosis treated with cephalexin who later showed a rash is presented and the previous literature is reviewed.	[ [ "cephalexin", "rash" ] ]
Cerebral and ocular toxicity induced by desferrioxamine.	[ [ "desferrioxamine", "Cerebral and ocular toxicity" ] ]
Both had impaired lung function and abnormal computed tomographic scans, and their condition improved when nitrofurantoin was withdrawn and corticosteroid treatment commenced.	[ [ "nitrofurantoin", "abnormal computed tomographic scans" ], [ "nitrofurantoin", "impaired lung function" ] ]
The clinical picture was identical to that of chloroquine and hydroxychloroquine maculopathy.	[ [ "chloroquine", "maculopathy" ], [ "hydroxychloroquine", "maculopathy" ] ]
Carbamazepine toxicity following Oxybutynin and Dantrolene administration: a case report.	[ [ "Dantrolene", "Carbamazepine toxicity" ], [ "Oxybutynin", "Carbamazepine toxicity" ], [ "Carbamazepine", "Carbamazepine toxicity" ] ]

Case study: adverse response to clonidine.

[ [ "clonidine", "adverse response" ] ]

The authors report two cases of delayed elimination of methotrexate in patients receiving ciprofloxacin, with severe toxicity.

[ [ "methotrexate", "delayed elimination" ], [ "ciprofloxacin", "toxicity" ], [ "ciprofloxacin", "delayed elimination" ] ]

Tubulointerstitial nephritis induced by the leukotriene receptor antagonist pranlukast.

[ [ "pranlukast", "Tubulointerstitial nephritis" ] ]

Alprazolam-induced mania: two clinical cases.

[ [ "Alprazolam", "mania" ] ]

Hepatotoxicity associated with use of D-penicillamine in rheumatoid arthritis.

[ [ "D-penicillamine", "Hepatotoxicity" ] ]

We report two new cases of sarcoidosis in two patients with hepatitis C virus infection treated with interferon alfa and ribavirin.

[ [ "interferon alfa", "sarcoidosis" ], [ "ribavirin", "sarcoidosis" ] ]

Behavioral side effects associated with clonazepam may include agitation, aggression, hyperactivity, irritability, property destruction, and temper tantrums.

[ [ "clonazepam", "hyperactivity" ], [ "clonazepam", "irritability" ], [ "clonazepam", "agitation" ], [ "clonazepam", "property destruction" ], [ "clonazepam", "temper tantrums" ], [ "clonazepam", "aggression" ] ]

Ciprofloxacin is one drug that has been reported to cause interstitial nephritis.

[ [ "Ciprofloxacin", "interstitial nephritis" ] ]

This latest (third) report suggests that the safety profile should be reexamined and at least raises the question of potential renal toxicity of interferons in MS.

[ [ "interferons", "renal toxicity" ] ]

There are major side effects of anastrozole including decrease in both lumbar spine and total hip bone mineral density, increase in the incidence of all bone fractures (especially fractures of spine, hip and wrist), joint disorders and increase in the cholesterol level.

[ [ "anastrozole", "decrease in both lumbar spine" ], [ "anastrozole", "increase in the incidence of all bone fractures" ], [ "anastrozole", "increase in the cholesterol level" ], [ "anastrozole", "joint disorders" ] ]

Renal damage associated with long term use of lithium carbonate.

[ [ "lithium carbonate", "Renal damage" ] ]

RESULTS: Replacing valproate with lamotrigine resulted in a decrease in serum testosterone concentrations in all 3 women.

[ [ "valproate", "serum testosterone" ] ]

Physicians should be aware of the risk of severe AIHA in CLL patients with a history of AIHA or positivation of the DAT during previous fludarabine administration, or in case of secondary fixation of complement to the red cell membrane occurring during fludarabine treatment.

[ [ "fludarabine", "positivation of the DAT" ], [ "fludarabine", "AIHA" ] ]

We present the cases of two female patients diagnosed with relapsing-remitting multiple sclerosis (RRMS) who developed inflammatory musculoskeletal manifestations, following IFN-beta therapy.

[ [ "IFN-beta", "inflammatory musculoskeletal manifestations" ] ]

While both amiodarone and digoxin can cause permanent visual changes, the ocular effects are often reversible.

[ [ "digoxin", "ocular effects" ], [ "digoxin", "visual changes" ], [ "amiodarone", "ocular effects" ], [ "amiodarone", "visual changes" ] ]

The fourth patient showed RLS symptoms that were initially caused by a 20-mg daily olanzapine dosage and were later mitigated when olanzapine was reduced and ropinirole was administered.

[ [ "olanzapine", "RLS symptoms" ] ]

Drug induced liver injury secondary to interferon-beta (IFN-beta) in multiple sclerosis.

[ [ "IFN-beta", "liver injury" ], [ "interferon-beta", "liver injury" ] ]

This case suggests that acyclovir when given intravenously in doses of 10 mg/kg may result in increased serum lithium concentrations.

[ [ "lithium", "increased serum lithium" ], [ "acyclovir", "increased serum lithium" ] ]

Seven of the eight cases of acute leukemia occurred in a series of 553 patients treated with Treosulfan for ovarian cancer in the period from 1970 to 1977 and followed closely for a total of 1159 patient-years up to February 1978.

[ [ "Treosulfan", "acute leukemia" ] ]

The major side effect of infliximab is infection.

[ [ "infliximab", "infection" ] ]

We report a case of a patient with ciprofloxacin-induced SJS and acute onset of VBDS, and reviewed the related literature.

[ [ "ciprofloxacin", "SJS" ], [ "ciprofloxacin", "VBDS" ] ]

The fever abated promptly following discontinuation of acyclovir, and radiographic abnormalities resolved over ten days.

[ [ "acyclovir", "fever" ] ]

The authors describe a patient with hemiparesis who developed the syndrome of irreversible lithium-effectuated neurotoxicity (SILENT) while being treated with lithium for a manic episode.

[ [ "lithium", "neurotoxicity" ] ]

Hemolytic uremic syndrome following the infusion of oxaliplatin: case report.

[ [ "oxaliplatin", "Hemolytic uremic syndrome" ] ]

PURPOSE: To report a case of traumatic flap dehiscence and Enterobacter keratitis 34 months after LASIK.

[ [ "LASIK", "traumatic flap dehiscence" ], [ "LASIK", "Enterobacter keratitis" ] ]

A 33-year-old man with a history of recreational benztropine abuse presented to the emergency department with confusion, abdominal pain, and distention.

[ [ "benztropine", "confusion" ], [ "benztropine", "abdominal pain" ], [ "benztropine", "distention" ] ]

The authors presented a case of pulmonary hypertension during lithium therapy, while she has been on lithium for 6 years.

[ [ "lithium", "pulmonary hypertension" ] ]

Phantom limb pain as a manifestation of paclitaxel neurotoxicity.

[ [ "paclitaxel", "Phantom limb pain" ], [ "paclitaxel", "neurotoxicity" ] ]

Myasthenic patients receiving ampicillin should be closely monitored for possible acute exacerbations.

[ [ "ampicillin", "acute exacerbations" ] ]

Acute nitrite toxicity results from industrial exposure, accidental ingestion (e.g., abuse of organic nitrites as an aphrodisiac, especially in the male homosexual population), and suicidal ingestion.

[ [ "nitrite", "nitrite toxicity" ] ]

Verapamil is widely used for the termination of paroxysmal supraventricular tachycardia (PSVT) with little proarrhythmic effect.

[ [ "Verapamil", "proarrhythmic effect" ] ]

Fatal eosinophilia myalgia syndrome in a marrow transplant patient attributed to total parenteral nutrition with a solution containing tryptophan.

[ [ "tryptophan", "Fatal eosinophilia myalgia syndrome" ] ]

Warfarin-induced skin necrosis and heparin-induced thrombocytopenia following mitral valve replacement for marantic endocarditis.

[ [ "Warfarin", "skin necrosis" ], [ "heparin", "thrombocytopenia" ] ]

In this case report, we have described a patient with Crohn's disease who developed subfulminant hepatitis B after the fourth infusion of infliximab due to an unrecognized HBs-antigen carrier state.

[ [ "infliximab", "subfulminant hepatitis B" ] ]

CASE REPORT: We report a case of intracerebral hemorrhage occurring in a middle-aged man who suffered from chronic sinusitis and had been ingesting pseudoephedrine daily for one year.

[ [ "pseudoephedrine", "intracerebral hemorrhage" ] ]

We describe a life threatening side effect of acute epoprostenol infusion (pulmonary edema) in a patient with pulmonary hypertension associated with limited scleroderma and discuss its management and potential etiology.

[ [ "epoprostenol", "pulmonary edema" ] ]

A case of a 53-year-old man who developed acute pneumonitis after bleomycin and moderate oxygen administration is presented.

[ [ "oxygen", "acute pneumonitis" ], [ "bleomycin", "acute pneumonitis" ] ]

Ciprofloxacin-induced toxic epidermal necrolysis in a patient with systemic lupus erythematosus.

[ [ "Ciprofloxacin", "toxic epidermal necrolysis" ] ]

We describe six patients who developed tardive dyskinesia after treatment with sulpiride for depression or gastrointestinal symptoms.

[ [ "sulpiride", "tardive dyskinesia" ] ]

Patients treated with L-asparaginase may present with hemorrhagic and thrombotic cerebrovascular events.

[ [ "L-asparaginase", "hemorrhagic" ], [ "L-asparaginase", "thrombotic cerebrovascular events" ] ]

Hemodialysis should be performed for rapid reversal of mannitol-induced ARF.

[ [ "mannitol", "ARF" ] ]

ADH hypersecretion in relation to plasma osmolality was reversed by mizoribin withdrawal, suggesting that bredinin might adversely induce SIADH.

[ [ "bredinin", "SIADH" ], [ "mizoribin", "ADH hypersecretion" ] ]

It should be emphasized that the recurrence of nephrotic syndrome was observed after the following chemotherapy, including M-CSF, whereas the bone marrow still remained completely remitted.

[ [ "M-CSF", "nephrotic syndrome" ] ]

Sweet's syndrome is an acute febrile neutrophilic dermatosis that is a known complication of the administration of filgrastim, a drug that causes increased neutrophil proliferation and differentiation.

[ [ "filgrastim", "acute febrile neutrophilic dermatosis" ], [ "filgrastim", "Sweet's syndrome" ] ]

Bisphosphonate-related osteonecrosis of the skull base.

[ [ "Bisphosphonate", "osteonecrosis of the skull base" ] ]

To treat hepatitis B, interferon alpha was administered until the proximal muscle weakness developed.

[ [ "interferon alpha", "muscle weakness" ] ]

Gangrene of the fingertips after bleomycin and methotrexate.

[ [ "bleomycin", "Gangrene" ], [ "methotrexate", "Gangrene" ] ]

Hepatotoxicity resolved once erlotinib was discontinued and serum transaminases returned to baseline normal values.

[ [ "erlotinib", "Hepatotoxicity" ] ]

There are now reports of liver failure following treatment of childhood cancers with AMD.

[ [ "AMD", "liver failure" ] ]

The multiple comedones and ruptured epidermoid cysts are newly reported adverse effects of imiquimod therapy.

[ [ "imiquimod", "multiple comedones" ], [ "imiquimod", "ruptured epidermoid cysts" ] ]

The authors report two cases of acute dystonic reactions (ADRs) as a side effect of lamivudine.

[ [ "lamivudine", "acute dystonic reactions" ], [ "lamivudine", "ADRs" ] ]

Administration of lamotrigine, especially in combination with valproic acid, may lead to the development of TEN.

[ [ "lamotrigine", "TEN" ], [ "valproic acid", "TEN" ] ]

Despite the known pulmonary side effects of nitrofurantoin, there is no report of this toxicity occurring in pregnant patients.

[ [ "nitrofurantoin", "pulmonary side effects" ] ]

Despite a response of the meningeal tumor the patient developed in the third week of MTX treatment a progressive visual loss and loss of consciousness which worsened during subsequent Ara-C treatment and led to death within 3 weeks.

[ [ "MTX", "progressive visual loss" ], [ "MTX", "death" ], [ "Ara-C", "death" ], [ "Ara-C", "loss of consciousness" ], [ "MTX", "loss of consciousness" ], [ "Ara-C", "progressive visual loss" ] ]

A boy with chronic neutropenia and recurrent inflammatory skin lesions developed multiple erythematous nodules following administration of G-CSF.

[ [ "G-CSF", "multiple erythematous nodules" ] ]

Infections are a major adverse effect during the treatment with anti-TNF-alpha.

[ [ "anti-TNF-alpha", "Infections" ] ]

We report a case admitted with a first-detected, symptomatic paroxysmal atrial fibrillation in a healthy patient after self-medication with vardenafil.

[ [ "vardenafil", "symptomatic paroxysmal atrial fibrillation" ] ]

Rapamycin/sirolimus-induced pneumonitis has been described previously in renal transplant recipients, and this report describes a stable heart-lung transplant recipient who developed a pulmonary infiltrate that reversed after ceasing SR therapy.

[ [ "Rapamycin", "pulmonary infiltrate" ], [ "SR", "pulmonary infiltrate" ], [ "sirolimus", "pulmonary infiltrate" ], [ "Rapamycin", "pneumonitis" ], [ "sirolimus", "pneumonitis" ] ]

Neuroleptic malignant syndrome in an adolescent receiving olanzapine-lithium combination therapy.

[ [ "lithium", "Neuroleptic malignant syndrome" ], [ "olanzapine", "Neuroleptic malignant syndrome" ] ]

Haemolytic-uraemic syndrome complicating long-term mitomycin C and 5-fluorouracil therapy for gastric carcinoma.

[ [ "mitomycin C", "Haemolytic-uraemic syndrome" ], [ "5-fluorouracil", "Haemolytic-uraemic syndrome" ] ]

Sulfadiazine crystalluria revisited.

[ [ "Sulfadiazine", "crystalluria" ] ]

CONCLUSIONS: This study confirmed that in most patients MTX-induced liver cirrhosis is not aggressive.

[ [ "MTX", "liver cirrhosis" ] ]

This report describes a case of paradoxical, intravenous valproic acid-induced seizure exacerbation in a child with juvenile absence epilepsy, documented by video-electroencephalography.

[ [ "valproic acid", "seizure exacerbation" ], [ "paradoxical", "seizure exacerbation" ] ]

Salicylate hepato toxicity in rheumatic fever.

[ [ "Salicylate", "hepato toxicity" ] ]

She developed a generalized rash and itching, sore throat, and dizziness approximately 4 hours after the first dose of capecitabine.

[ [ "capecitabine", "dizziness" ], [ "capecitabine", "sore throat" ], [ "capecitabine", "generalized rash" ], [ "capecitabine", "itching" ] ]

We describe a case of pneumonitis following local administration of methotrexate for nonsurgical termination of an ectopic pregnancy.

[ [ "methotrexate", "pneumonitis" ] ]

Halothane hepatitis and prompt resolution with methionine therapy: case report.

[ [ "Halothane", "hepatitis" ] ]

Oculomotor disturbances associated with 5-fluorouracil chemotherapy.

[ [ "5-fluorouracil", "Oculomotor disturbances" ] ]

Since early symptoms of the toxic effects of theophylline can mimic peptic ulcer disease, cimetidine might be prescribed for the gastrointestinal symptoms with subsequent worsening of theophylline poisoning.

[ [ "theophylline", "peptic ulcer disease" ] ]

Its overall toxicity is considerably less compared to standard induction chemotherapy; however, it is associated with a high incidence of a potentially fatal symptom complex referred to as "retinoic acid syndrome." This report describes a patient with APL who developed the syndrome a few weeks after initiating induction therapy with ATRA despite being treated for hyperleukocytosis.

[ [ "retinoic acid", "potentially fatal symptom" ], [ "retinoic acid", "retinoic acid syndrome" ], [ "retinoic acid", "toxicity" ] ]

These case reports provide evidence that 5-aminosalicylic acid may induce acute pancreatitis after long term treatment.

[ [ "5-aminosalicylic acid", "acute pancreatitis" ] ]

OBJECTIVE: We report a case of cutaneous KS lesions in a patient affected by CML treated with imatinib.

[ [ "imatinib", "cutaneous KS lesions" ] ]

Severe rhabdomyolysis following massive ingestion of oolong tea: caffeine intoxication with coexisting hyponatremia.

[ [ "oolong tea", "rhabdomyolysis" ], [ "caffeine", "caffeine intoxication" ], [ "caffeine", "rhabdomyolysis" ], [ "oolong tea", "caffeine intoxication" ] ]

Acute myeloid leukemia and lung cancer occurring in a chronic lymphocytic leukemia patient treated with fludarabine and autologous peripheral blood stem-cell transplantation.

[ [ "fludarabine", "Acute myeloid leukemia" ], [ "fludarabine", "lung cancer" ] ]

Ritonavir acted as a CYP3A4 inhibitor, diminishing carbamazepine metabolism and provoking an increase in serum levels and clinical toxicity.

[ [ "Ritonavir", "clinical toxicity" ], [ "Ritonavir", "diminishing carbamazepine metabolism" ], [ "Ritonavir", "increase in serum levels" ] ]

Isotretinoin teratogenicity.

[ [ "Isotretinoin", "teratogenicity" ] ]

Thrombotic stroke associated with the use of porcine factor VIII in a patient with acquired haemophilia.

[ [ "porcine factor VIII", "Thrombotic stroke" ] ]

To our knowledge, this is the first report of an angio-oedema associated with VRC.

[ [ "VRC", "angio-oedema" ] ]

Cholesterol crystal embolization-associated renal failure after therapy with recombinant tissue-type plasminogen activator.

[ [ "tissue-type plasminogen activator", "Cholesterol crystal embolization" ], [ "tissue-type plasminogen activator", "renal failure" ] ]

However, one patient exhibited severe hypersensitivity reactions including cardiac arrest and apnea, and another four patients developed eruptions, hypotension, and tachycardia soon after administration of CBDCA.

[ [ "CBDCA", "tachycardia" ], [ "CBDCA", "eruptions" ], [ "CBDCA", "apnea" ], [ "CBDCA", "severe hypersensitivity reactions" ], [ "CBDCA", "cardiac arrest" ], [ "CBDCA", "hypotension" ] ]

Use of the Naranjo adverse drug reaction probability scale indicated a probable relationship (score of 5) between the patient's development of hepatotoxicity and the TMP-SMX therapy.

[ [ "TMP-SMX", "hepatotoxicity" ] ]

On the second day of hospitalization, it was noted that the patient's dyspnea and sinus bradycardia could be related to a recent increase in his timolol dosage.

[ [ "timolol", "dyspnea" ], [ "timolol", "sinus bradycardia" ] ]

The current report describes a man who was prescribed zonisamide for epilepsy and subsequently developed widespread skin rash, acute kidney injury, high-grade fever, eosinophilia, liver dysfunction, lymphadenopathy and an increase in antihuman herpesvirus-6 immunoglobulin G titer.

[ [ "zonisamide", "acute kidney injury" ], [ "zonisamide", "high-grade fever" ], [ "zonisamide", "eosinophilia" ], [ "zonisamide", "liver dysfunction" ], [ "zonisamide", "skin rash" ], [ "zonisamide", "lymphadenopathy" ], [ "zonisamide", "an increase in antihuman herpesvirus-6 immunoglobulin G titer" ] ]

A potential role for renal and hepatic impairment in the observed protracted course of amiodarone-induced thyrotoxicosis is suggested.

[ [ "amiodarone", "thyrotoxicosis" ] ]

DISCUSSION: This case shows that switching to zidovudine potentially can lead to a hyperlactatemia relapse.

[ [ "zidovudine", "hyperlactatemia relapse" ] ]

We report a case of 48-year-old woman with seizure disorder on divalproex sodium (Depakote) who presented with dyspnea.

[ [ "Depakote", "dyspnea" ], [ "divalproex sodium", "dyspnea" ] ]

This case report illustrates the neurotoxicity unique to HDARAC.

[ [ "HDARAC", "neurotoxicity" ] ]

OBJECTIVE: To report on the possible development of serotonin syndrome in a patient receiving clomipramine after clozapine was withdrawn from the treatment regimen.

[ [ "clomipramine", "serotonin syndrome" ], [ "clozapine", "serotonin syndrome" ] ]

CASES: Two postmenopausal women treated with tamoxifen and progestational agents for breast carcinoma developed uterine enlargement and intermittent spotting.

[ [ "tamoxifen", "uterine enlargement" ], [ "tamoxifen", "intermittent spotting" ] ]

Motor fluctuations appear after 2-3 years of levodopa treatment, and affect at least 50% of patients after five years.

[ [ "levodopa", "Motor fluctuations" ] ]

Although the t-AML developed following oral etoposide therapy, the child had previously received high-dose, multiagent chemotherapy, and rearrangement of the MLL gene was not demonstrated.

[ [ "etoposide", "t-AML" ] ]

Recurrent palmar-plantar erythrodysaesthesia following high-dose cytarabine treatment for acute lymphoblastic leukemia.

[ [ "cytarabine", "palmar-plantar erythrodysaesthesia" ] ]

Troglitazone-induced fulminant hepatic failure.

[ [ "Troglitazone", "fulminant hepatic failure" ] ]

Pentazocine-induced fibrous myopathy and localized neuropathy.

[ [ "Pentazocine", "fibrous myopathy" ], [ "Pentazocine", "neuropathy" ] ]

We report four cases of encephalopathy coincident with elevated aluminum levels as well as one patient who developed seizures while receiving continuous bladder irrigations with alum.

[ [ "alum", "seizures" ], [ "alum", "elevated aluminum levels" ], [ "alum", "encephalopathy" ] ]

The case of a patient with infectious mononucleosis treated with cephalexin who later showed a rash is presented and the previous literature is reviewed.

[ [ "cephalexin", "rash" ] ]

Cerebral and ocular toxicity induced by desferrioxamine.

[ [ "desferrioxamine", "Cerebral and ocular toxicity" ] ]

Both had impaired lung function and abnormal computed tomographic scans, and their condition improved when nitrofurantoin was withdrawn and corticosteroid treatment commenced.

[ [ "nitrofurantoin", "abnormal computed tomographic scans" ], [ "nitrofurantoin", "impaired lung function" ] ]

The clinical picture was identical to that of chloroquine and hydroxychloroquine maculopathy.

[ [ "chloroquine", "maculopathy" ], [ "hydroxychloroquine", "maculopathy" ] ]

Carbamazepine toxicity following Oxybutynin and Dantrolene administration: a case report.

[ [ "Dantrolene", "Carbamazepine toxicity" ], [ "Oxybutynin", "Carbamazepine toxicity" ], [ "Carbamazepine", "Carbamazepine toxicity" ] ]