harpreetmann/entity_extraction_ade · Datasets at Hugging Face

text stringlengths 22 455	pairs listlengths 1 24
Primary CNS lymphoma regressed on withdrawal of MM.	[ [ "MM", "CNS lymphoma" ] ]
One patient on ouabain also developed cardiomyopathy.	[ [ "ouabain", "cardiomyopathy" ] ]
Second cancers including various types of hematological malignancy have been reported in patients with hairy cell leukemia treated with chemotherapy or interferon alfa.	[ [ "interferon alfa", "Second cancers" ], [ "interferon alfa", "hematological malignancy" ] ]
Renal hypophosphatemia in this patient was caused by the erroneous intake of 1 g doxycycline.	[ [ "doxycycline", "Renal hypophosphatemia" ] ]
Malignant mixed mullerian tumor of the uterus in a patient taking raloxifene.	[ [ "raloxifene", "Malignant mixed mullerian tumor of the uterus" ] ]
Hemodialysis was also shown to reverse ifosfamide-related neurotoxicity.	[ [ "ifosfamide", "neurotoxicity" ] ]
The condition should be suspected in patients who develop unexplained abdominal pain or collapse following vasopressin treatment.	[ [ "vasopressin", "abdominal pain" ], [ "vasopressin", "collapse" ] ]
The association of central diabetes insipidus (CDI) with lithium use is rare.	[ [ "lithium", "central diabetes insipidus" ], [ "lithium", "CDI" ] ]
CONCLUSIONS: The pathogenesis of methotrexate-induced papular eruption in collagen vascular diseases may suggest cutaneous small-vessel vasculitis.	[ [ "methotrexate", "papular eruption" ] ]
Until additional data are available, if intravenous acyclovir is administered concurrently with lithium, we recommend closely monitoring patients for signs of lithium toxicity and measuring serum lithium levels every second or third day.	[ [ "lithium", "lithium toxicity" ], [ "acyclovir", "lithium toxicity" ] ]
Such a case induced by hypothyroidism complicating long-term therapy with amiodarone in a 45 year old woman with pre-excitation is presented.	[ [ "amiodarone", "hypothyroidism" ] ]
Therefore, we concluded that this patient's pulmonary disease was caused by calcium stearate, an additive for an antihistaminic drug.	[ [ "calcium stearate", "pulmonary disease" ] ]
Worsening of neurologic syndrome in patients with Wilson's disease with initial penicillamine therapy.	[ [ "penicillamine", "Worsening of neurologic syndrome" ] ]
Morphea after bromocriptine therapy.	[ [ "bromocriptine", "Morphea" ] ]
Lichenoid drug eruption to salsalate.	[ [ "salsalate", "Lichenoid drug eruption" ] ]
We present the first case of a patient with priapism after oral intake of the phenothiazine prothipendylhydrochloride.	[ [ "prothipendylhydrochloride", "priapism" ] ]
All developed mucocutaneous side effects within 20 weeks of beginning im gold therapy, at a time when RA had improved markedly compared to pretreatment status.	[ [ "gold", "mucocutaneous side effects" ] ]
Splenic hemorrhage: a complication of tissue plasminogen activator treatment.	[ [ "tissue plasminogen activator", "Splenic hemorrhage" ] ]
L-Thyroxine-induced leukopenia in a patient with Hashimoto's disease: involvement of suppressor-cytotoxic T cells.	[ [ "L-Thyroxine", "leukopenia" ] ]
Such a rapid and relentless progression of methyldopa-induced liver injury is undoubtedly rare, but it may be prevented by careful supervision of patients who exhibit liver function abnormalities early in the course of therapy.	[ [ "methyldopa", "liver injury" ] ]
Severe hypo-alpha-lipoproteinemia during treatment with rosiglitazone.	[ [ "rosiglitazone", "Severe hypo-alpha-lipoproteinemia" ] ]
However here we reported two patients, presenting with PD during high dose colchicine treatment for familiar mediterranean fever (FMF).	[ [ "colchicine", "PD" ] ]
Two patients with HLH developed etoposide-related secondary acute myeloid leukemia (sAML) following therapy for HLH.	[ [ "etoposide", "secondary acute myeloid leukemia" ], [ "etoposide", "sAML" ] ]
It has been reported that fluoroquinolone antimicrobials prolong the corrected QT interval but rarely cause torsade de pointes.	[ [ "fluoroquinolone", "torsade de pointes" ] ]
Stevens-Johnson syndrome in a boy with nephrotic syndrome during prednisolone therapy.	[ [ "prednisolone", "Stevens-Johnson syndrome" ] ]
A 71-year-old man, who had a history of a previous bullous drug reaction to a sulfonamide, began receiving an ophthalmic preparation that contained sulfacetamide sodium.	[ [ "sulfonamide", "bullous drug reaction" ] ]
The purpose of this review is to increase awareness among physicians and other health care professionals that DIC may be a rare but potentially severe complication of anti-D IGIV treatment.	[ [ "anti-D IGIV", "DIC" ] ]
Although other nitrites induce methemoglobinemia, exposure to methyl nitrite during phenylpropanolamine production appears to be a new cause of occupational methemoglobinemia.	[ [ "methyl nitrite", "methemoglobinemia" ] ]
After ruling out a hydrotelluric source of fluorine, the patient's fluorosis was linked to chronic use of niflumic acid, following the publication in 1978 of the 2 previously reported cases affected by this drug.	[ [ "niflumic acid", "fluorosis" ] ]
PATIENTS: Three patients developed a reproductive endocrine disorder during treatment with valproate.	[ [ "valproate", "reproductive endocrine disorder" ] ]
Propafenone-induced ataxia: report of three cases.	[ [ "Propafenone", "ataxia" ] ]
CASE DESCRIPTION: A 59-year-old man with known neurocysticercosis developed a large cerebral infarction during praziquantel therapy.	[ [ "praziquantel", "large cerebral infarction" ] ]
INTRODUCTION: Although gefitinib used for the treatment of non-small-cell lung cancer is a well-known cause of interstitial lung disease (ILD), few case reports on erlotinib-induced ILD have been issued.	[ [ "gefitinib", "interstitial lung disease" ], [ "erlotinib", "ILD" ], [ "gefitinib", "ILD" ] ]
Three patients with niacin-induced visual symptoms had cystoid maculopathy without leakage on fluorescein angiography, and a fourth patient with no fundus abnormality experienced cessation of visual symptoms upon discontinuation of niacin.	[ [ "niacin", "cystoid maculopathy" ], [ "niacin", "visual symptoms" ] ]
We report a 44-year-old woman with t-MDS (refractory anemia with excess blasts) following treatment of recurrent anaplastic astrocytoma with temozolomide (TMZ).	[ [ "TMZ", "refractory anemia with excess blasts" ], [ "temozolomide", "refractory anemia with excess blasts" ] ]
Fortunately, a hypersensitivity reaction to one formulation of cyclosporine does not preclude use of a different formulation.	[ [ "cyclosporine", "hypersensitivity reaction" ] ]
A case report is presented concerning the administration of ketanserin in the treatment of pulmonary vasoconstriction and right ventricular failure following the infusion of protamine in a patient undergoing coronary artery bypass surgery and mitral valve replacement.	[ [ "protamine", "right ventricular failure" ], [ "protamine", "pulmonary vasoconstriction" ] ]
We report a case of successful surgical management of arterial thrombosis after percutaneous thrombin injection of a femoral artery pseudoaneurysm in a 69-year-old woman.	[ [ "thrombin", "arterial thrombosis" ] ]
Methotrexate induced sprue-like syndrome.	[ [ "Methotrexate", "sprue-like syndrome" ] ]
Since its FDA approval in 2002, there are no known citations of ezetimibe-induced pancreatitis.	[ [ "ezetimibe", "pancreatitis" ] ]
We describe a 57-year-old man with acral erythrocyanosis progressing to acute digital ischemia and gangrene that developed after combined chemotherapy (bleomycin and methotrexate) used to treat a metastatic squamous cell carcinoma of the hypopharynx.	[ [ "bleomycin", "gangrene" ], [ "bleomycin", "acute digital ischemia" ], [ "methotrexate", "gangrene" ], [ "methotrexate", "acute digital ischemia" ] ]
We describe a continuous ambulatory peritoneal dialysis (CAPD) patient that developed vancomycin-induced agranulocytosis during treatment for methicillin-resistant Staphylococcus aureus (MRSA)-associated external cuff infection and pneumonia.	[ [ "vancomycin", "agranulocytosis" ] ]
However, other factors or drugs (e.g. cresol) are thought to induce MH.	[ [ "cresol", "MH" ] ]
An adolescent male developed acute pancreatitis and pseudocyst of the pancreas 16 weeks after cessation of intramuscular L-asparaginase.	[ [ "L-asparaginase", "acute pancreatitis" ], [ "L-asparaginase", "pseudocyst of the pancreas" ] ]
A 43-year-old white man developed a shallow erosion of a psoriatic plaque after chronic administration of methotrexate.	[ [ "methotrexate", "erosion of a psoriatic plaque" ] ]
OBJECTIVE: To report a case of angioedema associated with losartan administration.	[ [ "losartan", "angioedema" ] ]
Rofecoxib, used for dysmenorrhea, caused a herpetiform fixed drug eruption predominantly involving the lips with classic clinical and histological findings in a red-brown lesion on the dorsal hand.	[ [ "Rofecoxib", "herpetiform fixed drug eruption" ], [ "Rofecoxib", "red-brown lesion" ] ]
The possible effects of tamoxifen upon the uterus are discussed in this article, in view of reports of tamoxifen associated with endometrial carcinoma and endometriosis.	[ [ "tamoxifen", "endometriosis" ], [ "tamoxifen", "endometrial carcinoma" ] ]
Pulmonary toxicity associated with erlotinib.	[ [ "erlotinib", "Pulmonary toxicity" ] ]
Unique behavioral change with cinepazide in parkinsonism.	[ [ "cinepazide", "behavioral change" ] ]
The use of methotrexate (MTX) has been contraindicated for treatment of severe psoriasis in HIV infection on the basis of six previously reported cases in which MTX appeared to potentiate opportunistic infections and accelerate HIV disease.	[ [ "methotrexate", "accelerate HIV disease" ], [ "MTX", "accelerate HIV disease" ] ]
Amiodarone was the third drug to induce AVT in this patient; she received 200 mg/day six days per week for six months.	[ [ "Amiodarone", "AVT" ] ]
Both patients were then treated with a carboplatin alternative to cisplatin in the following courses, which resulted in neither a relapse of the colitis nor a recurrence of the malignancies up to this time.	[ [ "cisplatin", "colitis" ] ]
Ethambutol is frequently used in the treatment of tuberculosis, and, although optic neuropathies have been reported with the use of ethambutol, this adverse side effect has been considered to be rare and generally reversible with discontinuation of the medication.	[ [ "Ethambutol", "optic neuropathies" ] ]
We report a case of severe anemia, which responded well to steroid therapy, in a patient receiving IL-2 plus IFN-alpha for metastatic renal cell carcinoma.	[ [ "IFN-alpha", "severe anemia" ], [ "IL-2", "severe anemia" ] ]
Methotrexate-induced papular eruption following treatment of psoriasis has not been previously reported.	[ [ "Methotrexate", "papular eruption" ] ]
In a female with acute lymphoblastic leukemia, inadvertent doxorubicin administration intrathecally caused severe, life-threatening, acute encephalopathy with high-pressure hydrocephalus.	[ [ "doxorubicin", "high-pressure hydrocephalus" ], [ "doxorubicin", "acute encephalopathy" ] ]
We reviewed the records of 3 patients with lymphoproliferative disorders who experienced acute coronary syndromes associated with their initial infusion of rituximab.	[ [ "rituximab", "acute coronary syndromes" ] ]
Two patients had ampicillin-associated seizures.	[ [ "ampicillin", "seizures" ] ]
Agranulocytosis and granulocytopenia associated with quetiapine.	[ [ "quetiapine", "Agranulocytosis" ], [ "quetiapine", "granulocytopenia" ] ]
Acute asthma associated with sustained-release verapamil.	[ [ "verapamil", "Acute asthma" ] ]
He became hyperkalemic on rechallenge with timolol and normokalemic following its withdrawal.	[ [ "timolol", "hyperkalemic" ] ]
Syncope in a 65-year-old woman after nitrate ingestion.	[ [ "nitrate", "Syncope" ] ]
Because of a hypersensitivity reaction, initial therapy with penicillin G and gentamicin was stopped and substituted with cefazolin.	[ [ "gentamicin", "hypersensitivity reaction" ], [ "penicillin G", "hypersensitivity reaction" ] ]
CONCLUSIONS: Jet-injection devices might constitute a helpful method to treat those patients affected by severe human insulin-induced lipoatrophy.	[ [ "human insulin", "lipoatrophy" ] ]
Methylphenidate (Ritalin)-associated cataract and glaucoma.	[ [ "Ritalin", "cataract" ], [ "Methylphenidate", "glaucoma" ], [ "Ritalin", "glaucoma" ], [ "Methylphenidate", "cataract" ] ]
This is, to the best of our knowledge, the first report of a case in which agranulocytosis followed treatment with both propylthiouracil and methimazole in the same patient.	[ [ "propylthiouracil", "agranulocytosis" ], [ "methimazole", "agranulocytosis" ] ]
A case of phenytoin-induced hepatitis with mononucleosis is reported, and syndromes associated with phenytoin hypersensitivity reactions are discussed.	[ [ "phenytoin", "hepatitis" ], [ "phenytoin", "mononucleosis" ], [ "phenytoin", "hypersensitivity reactions" ] ]
Rebound hyperglycemia was observed with both intermediate (neutral protamine hagedorn) and long-acting (protamine zinc iletin) insulins, and the range of insulin doses at which the disorder developed overlapped previously determined therapeutic doses for these insulins in the cat.	[ [ "protamine hagedorn", "Rebound hyperglycemia" ], [ "protamine zinc iletin", "Rebound hyperglycemia" ] ]
These nail changes gradually disappeared when the dose of clofazimine was reduced.	[ [ "clofazimine", "nail changes" ] ]
Acute generalized exanthematous pustulosis caused by morphine, confirmed by positive patch test and lymphocyte transformation test.	[ [ "morphine", "Acute generalized exanthematous pustulosis" ] ]
We report an unusual case of massive fluoxetine ingestion resulting in neurological and cardiovascular toxicity resulting in death.	[ [ "fluoxetine", "death" ], [ "fluoxetine", "neurological and cardiovascular toxicity" ] ]
We reviewed the literature in an attempt to characterize the pattern and predictors of TMP/SMX-induced aseptic meningitis.	[ [ "TMP", "aseptic meningitis" ], [ "SMX", "aseptic meningitis" ] ]
In both cases, high fever, skin rash, liver dysfunction and atypical lymphocytosis developed 3 weeks after initiating treatment with SASP.	[ [ "SASP", "skin rash" ], [ "SASP", "liver dysfunction" ], [ "SASP", "high fever" ], [ "SASP", "atypical lymphocytosis" ] ]
A case of barbiturate-induced submassive hepatic necrosis is presented and the literature is reviewed.	[ [ "barbiturate", "submassive hepatic necrosis" ] ]
The patient, a 28-year-old man suffering from panic disorder, developed several first-rank symptoms during fluvoxamine administration.	[ [ "fluvoxamine", "first-rank symptoms" ] ]
Ovarian endometrioid carcinoma and endometriosis developing in a postmenopausal breast cancer patient during tamoxifen therapy: a case report and review of the literature.	[ [ "tamoxifen", "endometriosis" ], [ "tamoxifen", "Ovarian endometrioid carcinoma" ] ]
Drug rash with eosinophilia and systemic symptoms after chlorambucil treatment in chronic lymphocytic leukaemia.	[ [ "chlorambucil", "Drug rash with eosinophilia and systemic symptoms" ] ]
Nail-changes induced by penicillamine.	[ [ "penicillamine", "Nail-changes" ] ]
Leflunomide-induced toxic epidermal necrolysis in a patient with rheumatoid arthritis.	[ [ "Leflunomide", "toxic epidermal necrolysis" ] ]
We report a case of intrathecal methotrexate neurotoxicity manifesting as left arm weakness and aphasia.	[ [ "methotrexate", "aphasia" ], [ "methotrexate", "neurotoxicity" ], [ "methotrexate", "left arm weakness" ] ]
Well-differentiated endometrial adenocarcinoma of the secretory type (FIGO Grade 1) with minimal myometrial invasion occurred in a postmenopausal patient on tamoxifen therapy 5 years after mastectomy for breast carcinoma.	[ [ "tamoxifen", "endometrial adenocarcinoma of the secretory type" ] ]
Biopsy-proven acute interstitial nephritis associated with the tyrosine kinase inhibitor sunitinib: a class effect?	[ [ "sunitinib", "acute interstitial nephritis" ] ]
Multiple sclerosis-like disease secondary to alpha interferon.	[ [ "alpha interferon", "Multiple sclerosis-like disease" ] ]
Papilledema without peripheral neuropathy in a patient taking perhexiline maleate.	[ [ "perhexiline maleate", "Papilledema" ] ]
The present report suggests that clarithromycin coadministration induces increased plasma carbamazepine concentrations, which may result in carbamazepine toxicity.	[ [ "clarithromycin", "carbamazepine toxicity" ], [ "carbamazepine", "increased plasma carbamazepine" ], [ "clarithromycin", "increased plasma carbamazepine" ], [ "carbamazepine", "carbamazepine toxicity" ] ]
We believe that mucositis was a contributing factor to this case of fatal hyperkalemia after administration of succinylcholine, with a mechanism similar to that reported with thermal injury.	[ [ "succinylcholine", "fatal hyperkalemia" ] ]
CONCLUSIONS: Although budesonide may be beneficial because of its anti-inflammatory effects, clinicians should be alert to its potential for causing contact dermatitis.	[ [ "budesonide", "contact dermatitis" ] ]
Pulmonary fibrosis associated with nabumetone.	[ [ "nabumetone", "Pulmonary fibrosis" ] ]
Gliclazide-induced acute hepatitis.	[ [ "Gliclazide", "acute hepatitis" ] ]
These two cases highlight the importance of considering lopinavir/ritonavir induced arrhythmias when dealing with HIV-positive individuals.	[ [ "lopinavir", "arrhythmias" ], [ "ritonavir", "arrhythmias" ] ]
Pemphigus foliaceus was seen in a patient with pulmonary tuberculosis during rifampicin therapy.	[ [ "rifampicin", "Pemphigus foliaceus" ] ]
CONCLUSION: The new quinolone derivatives (levofloxacin, sparfloxacin, grepafloxacin, trovafloxacin, gatifloxacin and moxifloxacin), also called gyrase inhibitors, are known for their potential to cause central nervous system-related adverse effects, including headache, dizziness and insomnia.	[ [ "grepafloxacin", "insomnia" ], [ "sparfloxacin", "headache" ], [ "moxifloxacin", "insomnia" ], [ "grepafloxacin", "dizziness" ], [ "sparfloxacin", "insomnia" ], [ "grepafloxacin", "headache" ], [ "gatifloxacin", "dizziness" ], [ "gatifloxacin", "headache" ], [ "trovafloxacin", "insomnia" ], [ "levofloxacin", "headache" ], [ "moxifloxacin", "headache" ], [ "moxifloxacin", "dizziness" ], [ "sparfloxacin", "dizziness" ], [ "trovafloxacin", "headache" ], [ "trovafloxacin", "dizziness" ], [ "levofloxacin", "insomnia" ], [ "levofloxacin", "dizziness" ], [ "gatifloxacin", "insomnia" ] ]
A case of metoclopramide-induced oculogyric crisis in a 16-year-old girl with cystic fibrosis.	[ [ "metoclopramide", "oculogyric crisis" ] ]
Chlorambucil-induced chromosome damage to human lymphocytes is dose-dependent and cumulative.	[ [ "Chlorambucil", "chromosome damage" ] ]
Stroke is an infrequent but recognized complication of heroin addiction.	[ [ "heroin", "Stroke" ] ]
Acute renal failure in a patient treated by continuous povidone-iodine mediastinal irrigation.	[ [ "iodine", "Acute renal failure" ], [ "povidone", "Acute renal failure" ] ]
The second had acute cystitis and was treated by sulphonamide and the third developed myopia coincident with metronidazole treatment for trichomonas vaginalis.	[ [ "sulphonamide", "myopia" ], [ "metronidazole", "myopia" ] ]
It was hypothesized that valproic acid may interfere with glucuronidation of lamotrigine, leading to increased serum lamotrigine levels, or perhaps alter the drug's metabolism, resulting in accumulation of a toxic intermediate metabolite.	[ [ "lamotrigine", "accumulation of a toxic intermediate metabolite" ], [ "lamotrigine", "increased serum lamotrigine levels" ], [ "valproic acid", "increased serum lamotrigine levels" ], [ "valproic acid", "accumulation of a toxic intermediate metabolite" ] ]
Two cases of widespread cutaneous vasculitis are described in association with diltiazem, a recently introduced calcium antagonist.	[ [ "diltiazem", "cutaneous vasculitis" ] ]

Primary CNS lymphoma regressed on withdrawal of MM.

[ [ "MM", "CNS lymphoma" ] ]

One patient on ouabain also developed cardiomyopathy.

[ [ "ouabain", "cardiomyopathy" ] ]

Second cancers including various types of hematological malignancy have been reported in patients with hairy cell leukemia treated with chemotherapy or interferon alfa.

[ [ "interferon alfa", "Second cancers" ], [ "interferon alfa", "hematological malignancy" ] ]

Renal hypophosphatemia in this patient was caused by the erroneous intake of 1 g doxycycline.

[ [ "doxycycline", "Renal hypophosphatemia" ] ]

Malignant mixed mullerian tumor of the uterus in a patient taking raloxifene.

[ [ "raloxifene", "Malignant mixed mullerian tumor of the uterus" ] ]

Hemodialysis was also shown to reverse ifosfamide-related neurotoxicity.

[ [ "ifosfamide", "neurotoxicity" ] ]

The condition should be suspected in patients who develop unexplained abdominal pain or collapse following vasopressin treatment.

[ [ "vasopressin", "abdominal pain" ], [ "vasopressin", "collapse" ] ]

The association of central diabetes insipidus (CDI) with lithium use is rare.

[ [ "lithium", "central diabetes insipidus" ], [ "lithium", "CDI" ] ]

CONCLUSIONS: The pathogenesis of methotrexate-induced papular eruption in collagen vascular diseases may suggest cutaneous small-vessel vasculitis.

[ [ "methotrexate", "papular eruption" ] ]

Until additional data are available, if intravenous acyclovir is administered concurrently with lithium, we recommend closely monitoring patients for signs of lithium toxicity and measuring serum lithium levels every second or third day.

[ [ "lithium", "lithium toxicity" ], [ "acyclovir", "lithium toxicity" ] ]

Such a case induced by hypothyroidism complicating long-term therapy with amiodarone in a 45 year old woman with pre-excitation is presented.

[ [ "amiodarone", "hypothyroidism" ] ]

Therefore, we concluded that this patient's pulmonary disease was caused by calcium stearate, an additive for an antihistaminic drug.

[ [ "calcium stearate", "pulmonary disease" ] ]

Worsening of neurologic syndrome in patients with Wilson's disease with initial penicillamine therapy.

[ [ "penicillamine", "Worsening of neurologic syndrome" ] ]

Morphea after bromocriptine therapy.

[ [ "bromocriptine", "Morphea" ] ]

Lichenoid drug eruption to salsalate.

[ [ "salsalate", "Lichenoid drug eruption" ] ]

We present the first case of a patient with priapism after oral intake of the phenothiazine prothipendylhydrochloride.

[ [ "prothipendylhydrochloride", "priapism" ] ]

All developed mucocutaneous side effects within 20 weeks of beginning im gold therapy, at a time when RA had improved markedly compared to pretreatment status.

[ [ "gold", "mucocutaneous side effects" ] ]

Splenic hemorrhage: a complication of tissue plasminogen activator treatment.

[ [ "tissue plasminogen activator", "Splenic hemorrhage" ] ]

L-Thyroxine-induced leukopenia in a patient with Hashimoto's disease: involvement of suppressor-cytotoxic T cells.

[ [ "L-Thyroxine", "leukopenia" ] ]

Such a rapid and relentless progression of methyldopa-induced liver injury is undoubtedly rare, but it may be prevented by careful supervision of patients who exhibit liver function abnormalities early in the course of therapy.

[ [ "methyldopa", "liver injury" ] ]

Severe hypo-alpha-lipoproteinemia during treatment with rosiglitazone.

[ [ "rosiglitazone", "Severe hypo-alpha-lipoproteinemia" ] ]

However here we reported two patients, presenting with PD during high dose colchicine treatment for familiar mediterranean fever (FMF).

[ [ "colchicine", "PD" ] ]

Two patients with HLH developed etoposide-related secondary acute myeloid leukemia (sAML) following therapy for HLH.

[ [ "etoposide", "secondary acute myeloid leukemia" ], [ "etoposide", "sAML" ] ]

It has been reported that fluoroquinolone antimicrobials prolong the corrected QT interval but rarely cause torsade de pointes.

[ [ "fluoroquinolone", "torsade de pointes" ] ]

Stevens-Johnson syndrome in a boy with nephrotic syndrome during prednisolone therapy.

[ [ "prednisolone", "Stevens-Johnson syndrome" ] ]

A 71-year-old man, who had a history of a previous bullous drug reaction to a sulfonamide, began receiving an ophthalmic preparation that contained sulfacetamide sodium.

[ [ "sulfonamide", "bullous drug reaction" ] ]

The purpose of this review is to increase awareness among physicians and other health care professionals that DIC may be a rare but potentially severe complication of anti-D IGIV treatment.

[ [ "anti-D IGIV", "DIC" ] ]

Although other nitrites induce methemoglobinemia, exposure to methyl nitrite during phenylpropanolamine production appears to be a new cause of occupational methemoglobinemia.

[ [ "methyl nitrite", "methemoglobinemia" ] ]

After ruling out a hydrotelluric source of fluorine, the patient's fluorosis was linked to chronic use of niflumic acid, following the publication in 1978 of the 2 previously reported cases affected by this drug.

[ [ "niflumic acid", "fluorosis" ] ]

PATIENTS: Three patients developed a reproductive endocrine disorder during treatment with valproate.

[ [ "valproate", "reproductive endocrine disorder" ] ]

Propafenone-induced ataxia: report of three cases.

[ [ "Propafenone", "ataxia" ] ]

CASE DESCRIPTION: A 59-year-old man with known neurocysticercosis developed a large cerebral infarction during praziquantel therapy.

[ [ "praziquantel", "large cerebral infarction" ] ]

INTRODUCTION: Although gefitinib used for the treatment of non-small-cell lung cancer is a well-known cause of interstitial lung disease (ILD), few case reports on erlotinib-induced ILD have been issued.

[ [ "gefitinib", "interstitial lung disease" ], [ "erlotinib", "ILD" ], [ "gefitinib", "ILD" ] ]

Three patients with niacin-induced visual symptoms had cystoid maculopathy without leakage on fluorescein angiography, and a fourth patient with no fundus abnormality experienced cessation of visual symptoms upon discontinuation of niacin.

[ [ "niacin", "cystoid maculopathy" ], [ "niacin", "visual symptoms" ] ]

We report a 44-year-old woman with t-MDS (refractory anemia with excess blasts) following treatment of recurrent anaplastic astrocytoma with temozolomide (TMZ).

[ [ "TMZ", "refractory anemia with excess blasts" ], [ "temozolomide", "refractory anemia with excess blasts" ] ]

Fortunately, a hypersensitivity reaction to one formulation of cyclosporine does not preclude use of a different formulation.

[ [ "cyclosporine", "hypersensitivity reaction" ] ]

A case report is presented concerning the administration of ketanserin in the treatment of pulmonary vasoconstriction and right ventricular failure following the infusion of protamine in a patient undergoing coronary artery bypass surgery and mitral valve replacement.

[ [ "protamine", "right ventricular failure" ], [ "protamine", "pulmonary vasoconstriction" ] ]

We report a case of successful surgical management of arterial thrombosis after percutaneous thrombin injection of a femoral artery pseudoaneurysm in a 69-year-old woman.

[ [ "thrombin", "arterial thrombosis" ] ]

Methotrexate induced sprue-like syndrome.

[ [ "Methotrexate", "sprue-like syndrome" ] ]

Since its FDA approval in 2002, there are no known citations of ezetimibe-induced pancreatitis.

[ [ "ezetimibe", "pancreatitis" ] ]

We describe a 57-year-old man with acral erythrocyanosis progressing to acute digital ischemia and gangrene that developed after combined chemotherapy (bleomycin and methotrexate) used to treat a metastatic squamous cell carcinoma of the hypopharynx.

[ [ "bleomycin", "gangrene" ], [ "bleomycin", "acute digital ischemia" ], [ "methotrexate", "gangrene" ], [ "methotrexate", "acute digital ischemia" ] ]

We describe a continuous ambulatory peritoneal dialysis (CAPD) patient that developed vancomycin-induced agranulocytosis during treatment for methicillin-resistant Staphylococcus aureus (MRSA)-associated external cuff infection and pneumonia.

[ [ "vancomycin", "agranulocytosis" ] ]

However, other factors or drugs (e.g. cresol) are thought to induce MH.

[ [ "cresol", "MH" ] ]

An adolescent male developed acute pancreatitis and pseudocyst of the pancreas 16 weeks after cessation of intramuscular L-asparaginase.

[ [ "L-asparaginase", "acute pancreatitis" ], [ "L-asparaginase", "pseudocyst of the pancreas" ] ]

A 43-year-old white man developed a shallow erosion of a psoriatic plaque after chronic administration of methotrexate.

[ [ "methotrexate", "erosion of a psoriatic plaque" ] ]

OBJECTIVE: To report a case of angioedema associated with losartan administration.

[ [ "losartan", "angioedema" ] ]

Rofecoxib, used for dysmenorrhea, caused a herpetiform fixed drug eruption predominantly involving the lips with classic clinical and histological findings in a red-brown lesion on the dorsal hand.

[ [ "Rofecoxib", "herpetiform fixed drug eruption" ], [ "Rofecoxib", "red-brown lesion" ] ]

The possible effects of tamoxifen upon the uterus are discussed in this article, in view of reports of tamoxifen associated with endometrial carcinoma and endometriosis.

[ [ "tamoxifen", "endometriosis" ], [ "tamoxifen", "endometrial carcinoma" ] ]

Pulmonary toxicity associated with erlotinib.

[ [ "erlotinib", "Pulmonary toxicity" ] ]

Unique behavioral change with cinepazide in parkinsonism.

[ [ "cinepazide", "behavioral change" ] ]

The use of methotrexate (MTX) has been contraindicated for treatment of severe psoriasis in HIV infection on the basis of six previously reported cases in which MTX appeared to potentiate opportunistic infections and accelerate HIV disease.

[ [ "methotrexate", "accelerate HIV disease" ], [ "MTX", "accelerate HIV disease" ] ]

Amiodarone was the third drug to induce AVT in this patient; she received 200 mg/day six days per week for six months.

[ [ "Amiodarone", "AVT" ] ]

Both patients were then treated with a carboplatin alternative to cisplatin in the following courses, which resulted in neither a relapse of the colitis nor a recurrence of the malignancies up to this time.

[ [ "cisplatin", "colitis" ] ]

Ethambutol is frequently used in the treatment of tuberculosis, and, although optic neuropathies have been reported with the use of ethambutol, this adverse side effect has been considered to be rare and generally reversible with discontinuation of the medication.

[ [ "Ethambutol", "optic neuropathies" ] ]

We report a case of severe anemia, which responded well to steroid therapy, in a patient receiving IL-2 plus IFN-alpha for metastatic renal cell carcinoma.

[ [ "IFN-alpha", "severe anemia" ], [ "IL-2", "severe anemia" ] ]

Methotrexate-induced papular eruption following treatment of psoriasis has not been previously reported.

[ [ "Methotrexate", "papular eruption" ] ]

In a female with acute lymphoblastic leukemia, inadvertent doxorubicin administration intrathecally caused severe, life-threatening, acute encephalopathy with high-pressure hydrocephalus.

[ [ "doxorubicin", "high-pressure hydrocephalus" ], [ "doxorubicin", "acute encephalopathy" ] ]

We reviewed the records of 3 patients with lymphoproliferative disorders who experienced acute coronary syndromes associated with their initial infusion of rituximab.

[ [ "rituximab", "acute coronary syndromes" ] ]

Two patients had ampicillin-associated seizures.

[ [ "ampicillin", "seizures" ] ]

Agranulocytosis and granulocytopenia associated with quetiapine.

[ [ "quetiapine", "Agranulocytosis" ], [ "quetiapine", "granulocytopenia" ] ]

Acute asthma associated with sustained-release verapamil.

[ [ "verapamil", "Acute asthma" ] ]

He became hyperkalemic on rechallenge with timolol and normokalemic following its withdrawal.

[ [ "timolol", "hyperkalemic" ] ]

Syncope in a 65-year-old woman after nitrate ingestion.

[ [ "nitrate", "Syncope" ] ]

Because of a hypersensitivity reaction, initial therapy with penicillin G and gentamicin was stopped and substituted with cefazolin.

[ [ "gentamicin", "hypersensitivity reaction" ], [ "penicillin G", "hypersensitivity reaction" ] ]

CONCLUSIONS: Jet-injection devices might constitute a helpful method to treat those patients affected by severe human insulin-induced lipoatrophy.

[ [ "human insulin", "lipoatrophy" ] ]

Methylphenidate (Ritalin)-associated cataract and glaucoma.

[ [ "Ritalin", "cataract" ], [ "Methylphenidate", "glaucoma" ], [ "Ritalin", "glaucoma" ], [ "Methylphenidate", "cataract" ] ]

This is, to the best of our knowledge, the first report of a case in which agranulocytosis followed treatment with both propylthiouracil and methimazole in the same patient.

[ [ "propylthiouracil", "agranulocytosis" ], [ "methimazole", "agranulocytosis" ] ]

A case of phenytoin-induced hepatitis with mononucleosis is reported, and syndromes associated with phenytoin hypersensitivity reactions are discussed.

[ [ "phenytoin", "hepatitis" ], [ "phenytoin", "mononucleosis" ], [ "phenytoin", "hypersensitivity reactions" ] ]

Rebound hyperglycemia was observed with both intermediate (neutral protamine hagedorn) and long-acting (protamine zinc iletin) insulins, and the range of insulin doses at which the disorder developed overlapped previously determined therapeutic doses for these insulins in the cat.

[ [ "protamine hagedorn", "Rebound hyperglycemia" ], [ "protamine zinc iletin", "Rebound hyperglycemia" ] ]

These nail changes gradually disappeared when the dose of clofazimine was reduced.

[ [ "clofazimine", "nail changes" ] ]

Acute generalized exanthematous pustulosis caused by morphine, confirmed by positive patch test and lymphocyte transformation test.

[ [ "morphine", "Acute generalized exanthematous pustulosis" ] ]

We report an unusual case of massive fluoxetine ingestion resulting in neurological and cardiovascular toxicity resulting in death.

[ [ "fluoxetine", "death" ], [ "fluoxetine", "neurological and cardiovascular toxicity" ] ]

We reviewed the literature in an attempt to characterize the pattern and predictors of TMP/SMX-induced aseptic meningitis.

[ [ "TMP", "aseptic meningitis" ], [ "SMX", "aseptic meningitis" ] ]

In both cases, high fever, skin rash, liver dysfunction and atypical lymphocytosis developed 3 weeks after initiating treatment with SASP.

[ [ "SASP", "skin rash" ], [ "SASP", "liver dysfunction" ], [ "SASP", "high fever" ], [ "SASP", "atypical lymphocytosis" ] ]

A case of barbiturate-induced submassive hepatic necrosis is presented and the literature is reviewed.

[ [ "barbiturate", "submassive hepatic necrosis" ] ]

The patient, a 28-year-old man suffering from panic disorder, developed several first-rank symptoms during fluvoxamine administration.

[ [ "fluvoxamine", "first-rank symptoms" ] ]

Ovarian endometrioid carcinoma and endometriosis developing in a postmenopausal breast cancer patient during tamoxifen therapy: a case report and review of the literature.

[ [ "tamoxifen", "endometriosis" ], [ "tamoxifen", "Ovarian endometrioid carcinoma" ] ]

Drug rash with eosinophilia and systemic symptoms after chlorambucil treatment in chronic lymphocytic leukaemia.

[ [ "chlorambucil", "Drug rash with eosinophilia and systemic symptoms" ] ]

Nail-changes induced by penicillamine.

[ [ "penicillamine", "Nail-changes" ] ]

Leflunomide-induced toxic epidermal necrolysis in a patient with rheumatoid arthritis.

[ [ "Leflunomide", "toxic epidermal necrolysis" ] ]

We report a case of intrathecal methotrexate neurotoxicity manifesting as left arm weakness and aphasia.

[ [ "methotrexate", "aphasia" ], [ "methotrexate", "neurotoxicity" ], [ "methotrexate", "left arm weakness" ] ]

Well-differentiated endometrial adenocarcinoma of the secretory type (FIGO Grade 1) with minimal myometrial invasion occurred in a postmenopausal patient on tamoxifen therapy 5 years after mastectomy for breast carcinoma.

[ [ "tamoxifen", "endometrial adenocarcinoma of the secretory type" ] ]

Biopsy-proven acute interstitial nephritis associated with the tyrosine kinase inhibitor sunitinib: a class effect?

[ [ "sunitinib", "acute interstitial nephritis" ] ]

Multiple sclerosis-like disease secondary to alpha interferon.

[ [ "alpha interferon", "Multiple sclerosis-like disease" ] ]

Papilledema without peripheral neuropathy in a patient taking perhexiline maleate.

[ [ "perhexiline maleate", "Papilledema" ] ]

The present report suggests that clarithromycin coadministration induces increased plasma carbamazepine concentrations, which may result in carbamazepine toxicity.

[ [ "clarithromycin", "carbamazepine toxicity" ], [ "carbamazepine", "increased plasma carbamazepine" ], [ "clarithromycin", "increased plasma carbamazepine" ], [ "carbamazepine", "carbamazepine toxicity" ] ]

We believe that mucositis was a contributing factor to this case of fatal hyperkalemia after administration of succinylcholine, with a mechanism similar to that reported with thermal injury.

[ [ "succinylcholine", "fatal hyperkalemia" ] ]

CONCLUSIONS: Although budesonide may be beneficial because of its anti-inflammatory effects, clinicians should be alert to its potential for causing contact dermatitis.

[ [ "budesonide", "contact dermatitis" ] ]

Pulmonary fibrosis associated with nabumetone.

[ [ "nabumetone", "Pulmonary fibrosis" ] ]

Gliclazide-induced acute hepatitis.

[ [ "Gliclazide", "acute hepatitis" ] ]

These two cases highlight the importance of considering lopinavir/ritonavir induced arrhythmias when dealing with HIV-positive individuals.

[ [ "lopinavir", "arrhythmias" ], [ "ritonavir", "arrhythmias" ] ]

Pemphigus foliaceus was seen in a patient with pulmonary tuberculosis during rifampicin therapy.

[ [ "rifampicin", "Pemphigus foliaceus" ] ]

CONCLUSION: The new quinolone derivatives (levofloxacin, sparfloxacin, grepafloxacin, trovafloxacin, gatifloxacin and moxifloxacin), also called gyrase inhibitors, are known for their potential to cause central nervous system-related adverse effects, including headache, dizziness and insomnia.

[ [ "grepafloxacin", "insomnia" ], [ "sparfloxacin", "headache" ], [ "moxifloxacin", "insomnia" ], [ "grepafloxacin", "dizziness" ], [ "sparfloxacin", "insomnia" ], [ "grepafloxacin", "headache" ], [ "gatifloxacin", "dizziness" ], [ "gatifloxacin", "headache" ], [ "trovafloxacin", "insomnia" ], [ "levofloxacin", "headache" ], [ "moxifloxacin", "headache" ], [ "moxifloxacin", "dizziness" ], [ "sparfloxacin", "dizziness" ], [ "trovafloxacin", "headache" ], [ "trovafloxacin", "dizziness" ], [ "levofloxacin", "insomnia" ], [ "levofloxacin", "dizziness" ], [ "gatifloxacin", "insomnia" ] ]

A case of metoclopramide-induced oculogyric crisis in a 16-year-old girl with cystic fibrosis.

[ [ "metoclopramide", "oculogyric crisis" ] ]

Chlorambucil-induced chromosome damage to human lymphocytes is dose-dependent and cumulative.

[ [ "Chlorambucil", "chromosome damage" ] ]

Stroke is an infrequent but recognized complication of heroin addiction.

[ [ "heroin", "Stroke" ] ]

Acute renal failure in a patient treated by continuous povidone-iodine mediastinal irrigation.

[ [ "iodine", "Acute renal failure" ], [ "povidone", "Acute renal failure" ] ]

The second had acute cystitis and was treated by sulphonamide and the third developed myopia coincident with metronidazole treatment for trichomonas vaginalis.

[ [ "sulphonamide", "myopia" ], [ "metronidazole", "myopia" ] ]

It was hypothesized that valproic acid may interfere with glucuronidation of lamotrigine, leading to increased serum lamotrigine levels, or perhaps alter the drug's metabolism, resulting in accumulation of a toxic intermediate metabolite.

[ [ "lamotrigine", "accumulation of a toxic intermediate metabolite" ], [ "lamotrigine", "increased serum lamotrigine levels" ], [ "valproic acid", "increased serum lamotrigine levels" ], [ "valproic acid", "accumulation of a toxic intermediate metabolite" ] ]

Two cases of widespread cutaneous vasculitis are described in association with diltiazem, a recently introduced calcium antagonist.

[ [ "diltiazem", "cutaneous vasculitis" ] ]