harpreetmann/entity_extraction_ade · Datasets at Hugging Face

text stringlengths 22 455	pairs listlengths 1 24
Pulmonary lymphohistiocytic reactions temporally related to etanercept therapy.	[ [ "etanercept", "Pulmonary lymphohistiocytic reactions" ] ]
We report the successful treatment of heparin-induced thrombocytopenia and subsequent hemorrhagic complications postoperatively in a 2-year-old child with Danaparoid (orgaran).	[ [ "heparin", "hemorrhagic complications" ], [ "heparin", "thrombocytopenia" ] ]
Toxic epidermal necrolysis resulted after 19 days of treatment with 5-fluorocytosine and amphotericin B.	[ [ "5-fluorocytosine", "Toxic epidermal necrolysis" ], [ "amphotericin B", "Toxic epidermal necrolysis" ] ]
In this article, we describe a Japanese patient with severe interstitial pneumonia probably caused by sorafenib treatment for metastatic renal cell carcinoma.	[ [ "sorafenib", "severe interstitial pneumonia" ] ]
A 62-year-old woman who was being treated for squamous cell carcinoma of the head and neck developed a chemotherapy-related hemolytic-uremic syndrome during the second cycle of neoadjuvant chemotherapy consisting of cisplatin, bleomycin, and methotrexate.	[ [ "bleomycin", "hemolytic-uremic syndrome" ], [ "methotrexate", "hemolytic-uremic syndrome" ], [ "cisplatin", "hemolytic-uremic syndrome" ] ]
Here we describe a patient with Crohn's disease who developed a severe infliximab infusion reaction (IIR), complicated 1 day later by severe swelling of the forearm and hand ipsilateral to the site of infliximab infusion.	[ [ "infliximab", "severe infliximab infusion reaction" ], [ "infliximab", "severe swelling of the forearm and hand ipsilateral" ], [ "infliximab", "IIR" ] ]
One other patient on digoxin stopped taking it and developed cardiomyopathy.	[ [ "digoxin", "cardiomyopathy" ] ]
Carboplatin hypersensitivity induced by low-dose paclitaxel/carboplatin in multiple platinum-treated patients with recurrent ovarian cancer.	[ [ "Carboplatin", "hypersensitivity" ], [ "carboplatin", "hypersensitivity" ], [ "paclitaxel", "hypersensitivity" ] ]
Tremor: a newly described adverse event with long-term itraconazole therapy.	[ [ "itraconazole", "Tremor" ] ]
Visual system side effects caused by parasympathetic dysfunction after botulinum toxin type B injections.	[ [ "botulinum toxin type B", "Visual system side effects" ], [ "botulinum toxin type B", "parasympathetic dysfunction" ] ]
This profile should trigger a "red flag" as to the possibility of phenobarbital behavioral side effects or exacerbation of preexisting maladaptive behaviors.	[ [ "phenobarbital", "behavioral side effects" ], [ "phenobarbital", "exacerbation of preexisting maladaptive behaviors" ] ]
Rhabdomyolysis following clarithromycin monotherapy.	[ [ "clarithromycin", "Rhabdomyolysis" ] ]
There have been several reported cases of omeprazole-induced AIN.	[ [ "omeprazole", "AIN" ] ]
L-asparaginase-induced pancreatitis has been reported during or closely following administration of the drug.	[ [ "L-asparaginase", "pancreatitis" ] ]
A woman with a 20-year history of acral pustular psoriasis of Hallopeau and recurrent pustular lesions of the forearms and lower legs, developed a B-cell lymphoma of the lip following 4 1/2 years of treatment with razoxane.	[ [ "razoxane", "B-cell lymphoma" ] ]
Two cases of childhood-onset schizophrenia associated with clozapine-induced akathisia responsive to beta-blocker treatment are described.	[ [ "clozapine", "akathisia" ] ]
Mesalamine-induced hypersensitivity pneumonitis.	[ [ "Mesalamine", "hypersensitivity pneumonitis" ] ]
Subfulminant hepatitis B after infliximab in Crohn's disease: need for HBV-screening?	[ [ "infliximab", "Subfulminant hepatitis B" ] ]
These findings suggest that the corneal and retinal changes are the result of a toxic effect of tamoxifen when used in the doses and duration described.	[ [ "tamoxifen", "corneal and retinal changes" ] ]
Tigecycline-induced acute pancreatitis: case report and literature review.	[ [ "Tigecycline", "acute pancreatitis" ] ]
Autopsy evidence of herpesvirus infection was found in visceral organs of four leukemic patients who had received large doses of cytarabine (cytosine arabinoside; Ara-C) shortly before their death.	[ [ "cytarabine", "herpesvirus infection" ], [ "cytosine arabinoside", "herpesvirus infection" ], [ "Ara-C", "herpesvirus infection" ] ]
Acute leukaemia during tamoxifen therapy.	[ [ "tamoxifen", "Acute leukaemia" ] ]
METHOD: The authors followed a patient with chronic HCV who received interferon and ribavirin and who developed hallucinations ultimately requiring psychiatric hospitalization.	[ [ "interferon", "hallucinations" ], [ "ribavirin", "hallucinations" ] ]
Cerebral edema associated with Gliadel wafers: two case studies.	[ [ "Gliadel", "Cerebral edema" ] ]
Thrombocytopenia with or without microangiopathy following quinine is often referred to as quinine "hypersensitivity." When schistocytes are present it is frequently termed "quinine-associated TTP/HUS." A severe deficiency of the vWF-cleaving protease, ADAMTS13, is associated with idiopathic TTP.	[ [ "quinine", "Thrombocytopenia" ], [ "quinine", "TTP/HUS" ] ]
The hepatic enzyme disturbances normalized after discontinuation of pegvisomant.	[ [ "pegvisomant", "hepatic enzyme disturbances" ] ]
The purpose of this study was to examine the incidence and cause of Clostridium difficile colitis occurring after cisplatin-based combination chemotherapy in ovarian cancer patients.	[ [ "cisplatin", "Clostridium difficile colitis" ] ]
DATA SYNTHESIS: A 49-year-old man developed symptoms of severe psychosis concomitant with ciprofloxacin (250 mg bid) treatment.	[ [ "ciprofloxacin", "severe psychosis" ] ]
Itch and skin rash from chocolate during fluoxetine and sertraline treatment: case report.	[ [ "fluoxetine", "skin rash" ], [ "sertraline", "Itch" ], [ "fluoxetine", "Itch" ], [ "sertraline", "skin rash" ] ]
One week after the initial-dose of adalimumab (160 mg), which was initiated due to an acute exacerbation of Crohn's disease, the patient developed a fulminant cardiomyopathy.	[ [ "adalimumab", "fulminant cardiomyopathy" ] ]
Acute dystonia with thalamic and brainstem lesions after initial penicillamine treatment in Wilson's disease.	[ [ "penicillamine", "thalamic and brainstem lesions" ], [ "penicillamine", "Acute dystonia" ] ]
The patient was enrolled in a weight-loss clinic, and his diabetes medications were adjusted.Subsequently, olanzapine was discontinued because of weight gain and uncontrolled diabetes.	[ [ "olanzapine", "weight gain" ], [ "olanzapine", "uncontrolled diabetes" ] ]
Some patients develop hypersensitivity rash in response to HCQ.	[ [ "HCQ", "hypersensitivity rash" ] ]
Markedly increased pigmementation of skin immediately overlying veins used for multiple 5-fluorouracil infusions was noted.	[ [ "5-fluorouracil", "increased pigmementation of skin" ] ]
Chronic hydroxychloroquine use associated with QT prolongation and refractory ventricular arrhythmia.	[ [ "hydroxychloroquine", "QT prolongation" ], [ "hydroxychloroquine", "refractory ventricular arrhythmia" ] ]
A case of aseptic pleuropericarditis in a patient with chronic plaque psoriasis under methotrexate therapy.	[ [ "methotrexate", "aseptic pleuropericarditis" ] ]
After infliximab treatment, additional sleep studies revealed an increase in the number of apneic events and SaO2 dips suggesting that TNFalpha plays an important role in the pathophysiology of sleep apnea.	[ [ "infliximab", "SaO2 dips" ], [ "infliximab", "increase in the number of apneic events" ] ]
It is presumed that her hyperchloremic metabolic acidosis was secondary to cholestyramine because of the similarity to pediatric reports; the rapid and lasting response to intravenous sodium bicarbonate; the absence of another etiology; normal serum potassium, chloride and bicarbonate despite continued spironolactone therapy after recovery.	[ [ "cholestyramine", "hyperchloremic metabolic acidosis" ] ]
There is evidence that the angiotensin II receptor antagonist, losartan, increases urate excretion by reducing reabsorption of urate in the renal proximal tubule.	[ [ "losartan", "increases urate excretion" ] ]
Pediatric heparin-induced thrombocytopenia: management with Danaparoid (orgaran).	[ [ "heparin", "thrombocytopenia" ] ]
Recently, CD20-negative tumors have been described after Rituximab therapy.	[ [ "Rituximab", "CD20-negative tumors" ] ]
Acute abdomen due to endometriosis in a premenopausal woman taking tamoxifen.	[ [ "tamoxifen", "endometriosis" ], [ "tamoxifen", "Acute abdomen" ] ]
Three of 50 patients treated with isotretinoin (1 mg/kg/day) for cystic acne complained of poor night vision and/or excessive glare sensitivity.	[ [ "isotretinoin", "poor night vision" ], [ "isotretinoin", "excessive glare sensitivity" ] ]
Temporary neurologic abnormalities were observed in one out of 23 patients undergoing chemotherapy with high-dose methotrexate (HD-MTX) for osteogenic sarcoma.	[ [ "methotrexate", "Temporary neurologic abnormalities" ] ]
OBJECTIVE: To investigate the mechanisms involved in hypersensitivity reactions to cyclosporine and determine the feasibility of future cyclosporine use.	[ [ "cyclosporine", "hypersensitivity reactions" ] ]
Acute interstitial pneumonia induced by ONO-1078 (pranlukast), a leukotriene receptor antagonist.	[ [ "ONO-1078", "interstitial pneumonia" ], [ "pranlukast", "interstitial pneumonia" ] ]
Although transient increases in ectopy after bretylium therapy have been described, presumably due to catecholamine release, the occurrence of life-threatening ventricular arrhythmia leading to cardiac arrest has not previously been emphasized.	[ [ "bretylium", "ventricular arrhythmia" ], [ "bretylium", "cardiac arrest" ] ]
A patient with generalized MG was effectively managed with MM but developed CNS lymphoma after 3 years of treatment.	[ [ "MM", "CNS lymphoma" ] ]
Mitomycin-C is used widely in the treatment of malignancies and is associated with serious dose related adverse effects including the occurrence of hemolytic uremic syndrome.	[ [ "Mitomycin-C", "hemolytic uremic syndrome" ] ]
A patient is described who developed a rapid onset of pulmonary fibrosis following treatment with a new non-steroidal anti-inflammatory drug, nabumetone.	[ [ "nabumetone", "pulmonary fibrosis" ] ]
Severe aphthous stomatitis associated with oral calcineurin and mTOR inhibitors.	[ [ "calcineurin", "Severe aphthous stomatitis" ] ]
The purpose of this report is to document a new case of in utero CP exposure with multiple congenital anomalies and to establish an apparent CP embryopathy phenotype.	[ [ "CP", "multiple congenital anomalies" ], [ "CP", "embryopathy" ] ]
Myasthenia gravis during low-dose IFN-alpha therapy for chronic hepatitis C.	[ [ "IFN-alpha", "Myasthenia gravis" ] ]
Despite minimal short-term side effects and apparent efficacy, chronic treatment of MG with MM may be associated with increased risk of lymphoproliferative disorders.	[ [ "MM", "lymphoproliferative disorders" ] ]
Herein, we describe a patient with AIDS who presented to medical attention with pancytopenia 48 months postchemotherapy with etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin, and rituximab (R-EPOCH) for diffuse large B-cell lymphoma.	[ [ "prednisone", "pancytopenia" ], [ "vincristine", "pancytopenia" ], [ "rituximab", "pancytopenia" ], [ "etoposide", "pancytopenia" ], [ "cyclophosphamide", "pancytopenia" ], [ "doxorubicin", "pancytopenia" ] ]
Evaluation revealed elevated serum LTG levels and no other etiology for encephalopathy.	[ [ "LTG", "elevated serum LTG levels" ] ]
Gold nephropathy due to auranofin obscured by tolmetin pseudoproteinuria.	[ [ "tolmetin", "Gold nephropathy" ], [ "Gold", "Gold nephropathy" ], [ "tolmetin", "pseudoproteinuria" ], [ "auranofin", "Gold nephropathy" ] ]
OBJECTIVE: To report the occurrence of anterior ischemic optic neuropathy as a complication of treatment with interferon alfa and to consider the possible underlying mechanisms for this association.	[ [ "interferon alfa", "anterior ischemic optic neuropathy" ] ]
A 7-year-old with congenital toxoplasmosis who took pyrimethamine and sulfadiazine for reactivated chorioretinitis developed fever, severe cutaneous involvement, swelling, abdominal pain and transaminitis, persisting weeks after withholding medicines.	[ [ "sulfadiazine", "transaminitis" ], [ "pyrimethamine", "fever" ], [ "sulfadiazine", "fever" ], [ "sulfadiazine", "swelling" ], [ "pyrimethamine", "abdominal pain" ], [ "pyrimethamine", "transaminitis" ], [ "sulfadiazine", "abdominal pain" ], [ "pyrimethamine", "swelling" ], [ "pyrimethamine", "severe cutaneous involvement" ], [ "sulfadiazine", "severe cutaneous involvement" ] ]
The fluorine contained in niflumic acid induced a marked densification of trabecular bone in all 3 cases.	[ [ "niflumic acid", "densification of trabecular bone" ] ]
The most likely cause of liver failure in this patient was, therefore, clarithromycin, which undergoes hepatic metabolism and has been reported to cause fulminant hepatic failure.	[ [ "clarithromycin", "liver failure" ], [ "clarithromycin", "fulminant hepatic failure" ] ]
A case of sideroblastic anemia is presented in a patient with a left ventricular assist device drive-line infection who was receiving linezolid, an antibiotic used for serious infections with gram-positive organisms.	[ [ "linezolid", "sideroblastic anemia" ] ]
We present a case of acute epinephrine toxicity resulting in acute myocardial ischemia in a young boy with combined variable immunodeficiency syndrome who developed severe allergic reaction to intravenous immunoglobulin, and was subsequently given epinephrine by mistake intravenously rather than subcutaneously.	[ [ "epinephrine", "acute myocardial ischemia" ], [ "epinephrine", "severe allergic reaction" ] ]
We report a premature infant who developed seizures associated with intraventricular administration of nafcillin and discuss the need for electroencephalographic monitoring of patients receiving intraventricular antibiotics.	[ [ "nafcillin", "seizures" ] ]
In vitro inhibition of hematopoiesis in a patient with systemic sclerosis treated with D-penicillamine.	[ [ "D-penicillamine", "inhibition of hematopoiesis" ] ]
This article presents a case of an atypical localized cutaneous eruption with an unusual course and protracted resolution time associated with sorafenib therapy.	[ [ "sorafenib", "atypical localized cutaneous eruption" ] ]
2-CdA typically causes a long-lasting state of immunodeficiency and the profound influence of this drug on the immune system has raised questions concerning the emergence of secondary neoplasms after its use.	[ [ "2-CdA", "immunodeficiency" ], [ "2-CdA", "secondary neoplasms" ] ]
This unusual pattern of low-grade endometrial carcinoma adds to the spectrum of uterine neoplasia associated with tamoxifen therapy.	[ [ "tamoxifen", "low-grade endometrial carcinoma" ], [ "tamoxifen", "uterine neoplasia" ] ]
Two patients who developed decreased visual acuity after several months of ethambutol treatment for Mycobacterium avium-intracellulare infection had bitemporal visual field defects that suggested optic chiasm damage.	[ [ "ethambutol", "bitemporal visual field defects" ], [ "ethambutol", "decreased visual acuity" ] ]
Methotrexate is an effective but potentially toxic treatment for psoriasis.	[ [ "Methotrexate", "potentially toxic" ] ]
For patients who suffer from osteogenic sarcoma and have anaphylactic reactions to MTX, this desensitization protocol will allow these patients to continue with needed therapeutic or palliative chemotherapy.	[ [ "MTX", "anaphylactic reactions" ] ]
RESULTS: A 44-year-old man taking naproxen for chronic low back pain and a 20-year-old woman on oxaprozin for rheumatoid arthritis presented with tense bullae and cutaneous fragility on the face and the back of the hands.	[ [ "oxaprozin", "cutaneous fragility" ], [ "naproxen", "cutaneous fragility" ], [ "naproxen", "tense bullae" ], [ "oxaprozin", "tense bullae" ] ]
CONCLUSIONS: This is the second case report that describes gemcitabine-induced radiation recall in rectus abdominus muscles after gemcitabine-based radiation therapy.	[ [ "gemcitabine", "radiation recall" ] ]
Case report: mannitol nephrotoxicity syndrome: role of hemodialysis and postulate of mechanisms.	[ [ "mannitol", "nephrotoxicity syndrome" ] ]
Indinavir-associated nephrolithiasis and chronic interstitial nephritis were the only possible causes identified in this patient.	[ [ "Indinavir", "interstitial nephritis" ], [ "Indinavir", "nephrolithiasis" ] ]
We report the first case of IHA associated with cefuroxime administration.	[ [ "cefuroxime", "IHA" ] ]
The authors think that although lamivudine is widely used and well tolerated, it can cause ADRs, which are reversible after drug withdrawal.	[ [ "lamivudine", "ADRs" ] ]
Parenteral pyridoxine, the specific antidote for INH-induced refractory seizures, should be readily available in every emergency department in the areas similarly experiencing increasing trends of TB.	[ [ "INH", "refractory seizures" ] ]
Cephalosporins are most likely associated with Vitamin K deficiency.	[ [ "Cephalosporins", "Vitamin K deficiency" ] ]
PVT during chemotherapy in children is a rare event and appears to be closely related to intensive chemotherapy containing busulfan and to be associated with HVOD.	[ [ "busulfan", "HVOD" ], [ "busulfan", "PVT" ] ]
Occult quinine-induced thrombocytopenia.	[ [ "quinine", "thrombocytopenia" ] ]
These multiple overlapping factors probably lead to rhabdomyolysis in a minority of patients receiving vasopressin infusion.	[ [ "vasopressin", "rhabdomyolysis" ] ]
This case highlights the possible development of acute coronary syndrome as a side effect of Capecitabine therapy.	[ [ "Capecitabine", "acute coronary syndrome" ] ]
However, an association of Ritalin with glaucoma has been reported.	[ [ "Ritalin", "glaucoma" ] ]
We report 4 patients, 2 on methylphenidate and 2 on dextroamphetamine who presented with acral cyanosis, livedo reticularis, or Raynaud phenomenon.	[ [ "dextroamphetamine", "Raynaud phenomenon" ], [ "methylphenidate", "Raynaud phenomenon" ], [ "methylphenidate", "acral cyanosis" ], [ "dextroamphetamine", "acral cyanosis" ], [ "methylphenidate", "livedo reticularis" ], [ "dextroamphetamine", "livedo reticularis" ] ]
A drug interaction between zafirlukast and theophylline.	[ [ "zafirlukast", "drug interaction" ], [ "theophylline", "drug interaction" ] ]
In this paper, we report a case of severe hypercalcemia of immobilization in a 40-year-old hemodialyzed woman treated by cinacalcet HCl for a severe HPTH-II (PTH>1,000 pg/mL).	[ [ "cinacalcet HCl", "severe hypercalcemia" ] ]
CONCLUSIONS: Clarithromycin may be a cause of fulminant liver failure either alone or by inhibiting the metabolism of other drugs.	[ [ "Clarithromycin", "fulminant liver failure" ] ]
Sporadic rippling muscle disease unmasked by simvastatin.	[ [ "simvastatin", "Sporadic rippling muscle disease" ] ]
We report here a case of TEN after administration of ciprofloxacin.	[ [ "ciprofloxacin", "TEN" ] ]
Moreover, treatment with immunosuppressive drugs such as cyclosporine, cisplatin, tacrolimus, and interferon-alpha can induce a condition resembling RPLS.	[ [ "cisplatin", "RPLS" ], [ "tacrolimus", "RPLS" ], [ "cyclosporine", "RPLS" ], [ "interferon-alpha", "RPLS" ] ]
Therapy with IFN-beta has rarely been associated with the development of autoimmune disorders.	[ [ "IFN-beta", "autoimmune disorders" ] ]
OBJECTIVE: To report a case of severe apnea in an infant exposed to lamotrigine through breast-feeding.	[ [ "lamotrigine", "severe apnea" ] ]
CONCLUSION: Marked visual field constriction appears to be associated with vigabatrin therapy.	[ [ "vigabatrin", "visual field constriction" ] ]
Acute pancreatitis in a child with idiopathic ulcerative colitis on long-term 5-aminosalicylic acid therapy.	[ [ "5-aminosalicylic acid", "Acute pancreatitis" ] ]
CONCLUSION: Lipoid pneumonia as a result of mineral oil aspiration still occurs in the pediatric population.	[ [ "mineral oil", "Lipoid pneumonia" ] ]
CONCLUSIONS: Topical brimonidine may be associated with central nervous system depression in infants.	[ [ "brimonidine", "central nervous system depression" ] ]
It carries a well-known risk of neutropenia and agranulocytosis, which necessitates the immediate discontinuation of clozapine.	[ [ "clozapine", "agranulocytosis" ], [ "clozapine", "neutropenia" ] ]
BACKGROUND: Methotrexate (MTX) may induce liver damage, which in some psoriatics will lead to fibrosis or cirrhosis.	[ [ "MTX", "liver damage" ], [ "Methotrexate", "cirrhosis" ], [ "Methotrexate", "liver damage" ], [ "MTX", "cirrhosis" ], [ "Methotrexate", "fibrosis" ], [ "MTX", "fibrosis" ] ]
Anaphylaxis to intrathecal diamorphine.	[ [ "diamorphine", "Anaphylaxis" ] ]

Pulmonary lymphohistiocytic reactions temporally related to etanercept therapy.

[ [ "etanercept", "Pulmonary lymphohistiocytic reactions" ] ]

We report the successful treatment of heparin-induced thrombocytopenia and subsequent hemorrhagic complications postoperatively in a 2-year-old child with Danaparoid (orgaran).

[ [ "heparin", "hemorrhagic complications" ], [ "heparin", "thrombocytopenia" ] ]

Toxic epidermal necrolysis resulted after 19 days of treatment with 5-fluorocytosine and amphotericin B.

[ [ "5-fluorocytosine", "Toxic epidermal necrolysis" ], [ "amphotericin B", "Toxic epidermal necrolysis" ] ]

In this article, we describe a Japanese patient with severe interstitial pneumonia probably caused by sorafenib treatment for metastatic renal cell carcinoma.

[ [ "sorafenib", "severe interstitial pneumonia" ] ]

A 62-year-old woman who was being treated for squamous cell carcinoma of the head and neck developed a chemotherapy-related hemolytic-uremic syndrome during the second cycle of neoadjuvant chemotherapy consisting of cisplatin, bleomycin, and methotrexate.

[ [ "bleomycin", "hemolytic-uremic syndrome" ], [ "methotrexate", "hemolytic-uremic syndrome" ], [ "cisplatin", "hemolytic-uremic syndrome" ] ]

Here we describe a patient with Crohn's disease who developed a severe infliximab infusion reaction (IIR), complicated 1 day later by severe swelling of the forearm and hand ipsilateral to the site of infliximab infusion.

[ [ "infliximab", "severe infliximab infusion reaction" ], [ "infliximab", "severe swelling of the forearm and hand ipsilateral" ], [ "infliximab", "IIR" ] ]

One other patient on digoxin stopped taking it and developed cardiomyopathy.

[ [ "digoxin", "cardiomyopathy" ] ]

Carboplatin hypersensitivity induced by low-dose paclitaxel/carboplatin in multiple platinum-treated patients with recurrent ovarian cancer.

[ [ "Carboplatin", "hypersensitivity" ], [ "carboplatin", "hypersensitivity" ], [ "paclitaxel", "hypersensitivity" ] ]

Tremor: a newly described adverse event with long-term itraconazole therapy.

[ [ "itraconazole", "Tremor" ] ]

Visual system side effects caused by parasympathetic dysfunction after botulinum toxin type B injections.

[ [ "botulinum toxin type B", "Visual system side effects" ], [ "botulinum toxin type B", "parasympathetic dysfunction" ] ]

This profile should trigger a "red flag" as to the possibility of phenobarbital behavioral side effects or exacerbation of preexisting maladaptive behaviors.

[ [ "phenobarbital", "behavioral side effects" ], [ "phenobarbital", "exacerbation of preexisting maladaptive behaviors" ] ]

Rhabdomyolysis following clarithromycin monotherapy.

[ [ "clarithromycin", "Rhabdomyolysis" ] ]

There have been several reported cases of omeprazole-induced AIN.

[ [ "omeprazole", "AIN" ] ]

L-asparaginase-induced pancreatitis has been reported during or closely following administration of the drug.

[ [ "L-asparaginase", "pancreatitis" ] ]

A woman with a 20-year history of acral pustular psoriasis of Hallopeau and recurrent pustular lesions of the forearms and lower legs, developed a B-cell lymphoma of the lip following 4 1/2 years of treatment with razoxane.

[ [ "razoxane", "B-cell lymphoma" ] ]

Two cases of childhood-onset schizophrenia associated with clozapine-induced akathisia responsive to beta-blocker treatment are described.

[ [ "clozapine", "akathisia" ] ]

Mesalamine-induced hypersensitivity pneumonitis.

[ [ "Mesalamine", "hypersensitivity pneumonitis" ] ]

Subfulminant hepatitis B after infliximab in Crohn's disease: need for HBV-screening?

[ [ "infliximab", "Subfulminant hepatitis B" ] ]

These findings suggest that the corneal and retinal changes are the result of a toxic effect of tamoxifen when used in the doses and duration described.

[ [ "tamoxifen", "corneal and retinal changes" ] ]

Tigecycline-induced acute pancreatitis: case report and literature review.

[ [ "Tigecycline", "acute pancreatitis" ] ]

Autopsy evidence of herpesvirus infection was found in visceral organs of four leukemic patients who had received large doses of cytarabine (cytosine arabinoside; Ara-C) shortly before their death.

[ [ "cytarabine", "herpesvirus infection" ], [ "cytosine arabinoside", "herpesvirus infection" ], [ "Ara-C", "herpesvirus infection" ] ]

Acute leukaemia during tamoxifen therapy.

[ [ "tamoxifen", "Acute leukaemia" ] ]

METHOD: The authors followed a patient with chronic HCV who received interferon and ribavirin and who developed hallucinations ultimately requiring psychiatric hospitalization.

[ [ "interferon", "hallucinations" ], [ "ribavirin", "hallucinations" ] ]

Cerebral edema associated with Gliadel wafers: two case studies.

[ [ "Gliadel", "Cerebral edema" ] ]

Thrombocytopenia with or without microangiopathy following quinine is often referred to as quinine "hypersensitivity." When schistocytes are present it is frequently termed "quinine-associated TTP/HUS." A severe deficiency of the vWF-cleaving protease, ADAMTS13, is associated with idiopathic TTP.

[ [ "quinine", "Thrombocytopenia" ], [ "quinine", "TTP/HUS" ] ]

The hepatic enzyme disturbances normalized after discontinuation of pegvisomant.

[ [ "pegvisomant", "hepatic enzyme disturbances" ] ]

The purpose of this study was to examine the incidence and cause of Clostridium difficile colitis occurring after cisplatin-based combination chemotherapy in ovarian cancer patients.

[ [ "cisplatin", "Clostridium difficile colitis" ] ]

DATA SYNTHESIS: A 49-year-old man developed symptoms of severe psychosis concomitant with ciprofloxacin (250 mg bid) treatment.

[ [ "ciprofloxacin", "severe psychosis" ] ]

Itch and skin rash from chocolate during fluoxetine and sertraline treatment: case report.

[ [ "fluoxetine", "skin rash" ], [ "sertraline", "Itch" ], [ "fluoxetine", "Itch" ], [ "sertraline", "skin rash" ] ]

One week after the initial-dose of adalimumab (160 mg), which was initiated due to an acute exacerbation of Crohn's disease, the patient developed a fulminant cardiomyopathy.

[ [ "adalimumab", "fulminant cardiomyopathy" ] ]

Acute dystonia with thalamic and brainstem lesions after initial penicillamine treatment in Wilson's disease.

[ [ "penicillamine", "thalamic and brainstem lesions" ], [ "penicillamine", "Acute dystonia" ] ]

The patient was enrolled in a weight-loss clinic, and his diabetes medications were adjusted.Subsequently, olanzapine was discontinued because of weight gain and uncontrolled diabetes.

[ [ "olanzapine", "weight gain" ], [ "olanzapine", "uncontrolled diabetes" ] ]

Some patients develop hypersensitivity rash in response to HCQ.

[ [ "HCQ", "hypersensitivity rash" ] ]

Markedly increased pigmementation of skin immediately overlying veins used for multiple 5-fluorouracil infusions was noted.

[ [ "5-fluorouracil", "increased pigmementation of skin" ] ]

Chronic hydroxychloroquine use associated with QT prolongation and refractory ventricular arrhythmia.

[ [ "hydroxychloroquine", "QT prolongation" ], [ "hydroxychloroquine", "refractory ventricular arrhythmia" ] ]

A case of aseptic pleuropericarditis in a patient with chronic plaque psoriasis under methotrexate therapy.

[ [ "methotrexate", "aseptic pleuropericarditis" ] ]

After infliximab treatment, additional sleep studies revealed an increase in the number of apneic events and SaO2 dips suggesting that TNFalpha plays an important role in the pathophysiology of sleep apnea.

[ [ "infliximab", "SaO2 dips" ], [ "infliximab", "increase in the number of apneic events" ] ]

It is presumed that her hyperchloremic metabolic acidosis was secondary to cholestyramine because of the similarity to pediatric reports; the rapid and lasting response to intravenous sodium bicarbonate; the absence of another etiology; normal serum potassium, chloride and bicarbonate despite continued spironolactone therapy after recovery.

[ [ "cholestyramine", "hyperchloremic metabolic acidosis" ] ]

There is evidence that the angiotensin II receptor antagonist, losartan, increases urate excretion by reducing reabsorption of urate in the renal proximal tubule.

[ [ "losartan", "increases urate excretion" ] ]

Pediatric heparin-induced thrombocytopenia: management with Danaparoid (orgaran).

[ [ "heparin", "thrombocytopenia" ] ]

Recently, CD20-negative tumors have been described after Rituximab therapy.

[ [ "Rituximab", "CD20-negative tumors" ] ]

Acute abdomen due to endometriosis in a premenopausal woman taking tamoxifen.

[ [ "tamoxifen", "endometriosis" ], [ "tamoxifen", "Acute abdomen" ] ]

Three of 50 patients treated with isotretinoin (1 mg/kg/day) for cystic acne complained of poor night vision and/or excessive glare sensitivity.

[ [ "isotretinoin", "poor night vision" ], [ "isotretinoin", "excessive glare sensitivity" ] ]

Temporary neurologic abnormalities were observed in one out of 23 patients undergoing chemotherapy with high-dose methotrexate (HD-MTX) for osteogenic sarcoma.

[ [ "methotrexate", "Temporary neurologic abnormalities" ] ]

OBJECTIVE: To investigate the mechanisms involved in hypersensitivity reactions to cyclosporine and determine the feasibility of future cyclosporine use.

[ [ "cyclosporine", "hypersensitivity reactions" ] ]

Acute interstitial pneumonia induced by ONO-1078 (pranlukast), a leukotriene receptor antagonist.

[ [ "ONO-1078", "interstitial pneumonia" ], [ "pranlukast", "interstitial pneumonia" ] ]

Although transient increases in ectopy after bretylium therapy have been described, presumably due to catecholamine release, the occurrence of life-threatening ventricular arrhythmia leading to cardiac arrest has not previously been emphasized.

[ [ "bretylium", "ventricular arrhythmia" ], [ "bretylium", "cardiac arrest" ] ]

A patient with generalized MG was effectively managed with MM but developed CNS lymphoma after 3 years of treatment.

[ [ "MM", "CNS lymphoma" ] ]

Mitomycin-C is used widely in the treatment of malignancies and is associated with serious dose related adverse effects including the occurrence of hemolytic uremic syndrome.

[ [ "Mitomycin-C", "hemolytic uremic syndrome" ] ]

A patient is described who developed a rapid onset of pulmonary fibrosis following treatment with a new non-steroidal anti-inflammatory drug, nabumetone.

[ [ "nabumetone", "pulmonary fibrosis" ] ]

Severe aphthous stomatitis associated with oral calcineurin and mTOR inhibitors.

[ [ "calcineurin", "Severe aphthous stomatitis" ] ]

The purpose of this report is to document a new case of in utero CP exposure with multiple congenital anomalies and to establish an apparent CP embryopathy phenotype.

[ [ "CP", "multiple congenital anomalies" ], [ "CP", "embryopathy" ] ]

Myasthenia gravis during low-dose IFN-alpha therapy for chronic hepatitis C.

[ [ "IFN-alpha", "Myasthenia gravis" ] ]

Despite minimal short-term side effects and apparent efficacy, chronic treatment of MG with MM may be associated with increased risk of lymphoproliferative disorders.

[ [ "MM", "lymphoproliferative disorders" ] ]

Herein, we describe a patient with AIDS who presented to medical attention with pancytopenia 48 months postchemotherapy with etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin, and rituximab (R-EPOCH) for diffuse large B-cell lymphoma.

[ [ "prednisone", "pancytopenia" ], [ "vincristine", "pancytopenia" ], [ "rituximab", "pancytopenia" ], [ "etoposide", "pancytopenia" ], [ "cyclophosphamide", "pancytopenia" ], [ "doxorubicin", "pancytopenia" ] ]

Evaluation revealed elevated serum LTG levels and no other etiology for encephalopathy.

[ [ "LTG", "elevated serum LTG levels" ] ]

Gold nephropathy due to auranofin obscured by tolmetin pseudoproteinuria.

[ [ "tolmetin", "Gold nephropathy" ], [ "Gold", "Gold nephropathy" ], [ "tolmetin", "pseudoproteinuria" ], [ "auranofin", "Gold nephropathy" ] ]

OBJECTIVE: To report the occurrence of anterior ischemic optic neuropathy as a complication of treatment with interferon alfa and to consider the possible underlying mechanisms for this association.

[ [ "interferon alfa", "anterior ischemic optic neuropathy" ] ]

A 7-year-old with congenital toxoplasmosis who took pyrimethamine and sulfadiazine for reactivated chorioretinitis developed fever, severe cutaneous involvement, swelling, abdominal pain and transaminitis, persisting weeks after withholding medicines.

[ [ "sulfadiazine", "transaminitis" ], [ "pyrimethamine", "fever" ], [ "sulfadiazine", "fever" ], [ "sulfadiazine", "swelling" ], [ "pyrimethamine", "abdominal pain" ], [ "pyrimethamine", "transaminitis" ], [ "sulfadiazine", "abdominal pain" ], [ "pyrimethamine", "swelling" ], [ "pyrimethamine", "severe cutaneous involvement" ], [ "sulfadiazine", "severe cutaneous involvement" ] ]

The fluorine contained in niflumic acid induced a marked densification of trabecular bone in all 3 cases.

[ [ "niflumic acid", "densification of trabecular bone" ] ]

The most likely cause of liver failure in this patient was, therefore, clarithromycin, which undergoes hepatic metabolism and has been reported to cause fulminant hepatic failure.

[ [ "clarithromycin", "liver failure" ], [ "clarithromycin", "fulminant hepatic failure" ] ]

A case of sideroblastic anemia is presented in a patient with a left ventricular assist device drive-line infection who was receiving linezolid, an antibiotic used for serious infections with gram-positive organisms.

[ [ "linezolid", "sideroblastic anemia" ] ]

We present a case of acute epinephrine toxicity resulting in acute myocardial ischemia in a young boy with combined variable immunodeficiency syndrome who developed severe allergic reaction to intravenous immunoglobulin, and was subsequently given epinephrine by mistake intravenously rather than subcutaneously.

[ [ "epinephrine", "acute myocardial ischemia" ], [ "epinephrine", "severe allergic reaction" ] ]

We report a premature infant who developed seizures associated with intraventricular administration of nafcillin and discuss the need for electroencephalographic monitoring of patients receiving intraventricular antibiotics.

[ [ "nafcillin", "seizures" ] ]

In vitro inhibition of hematopoiesis in a patient with systemic sclerosis treated with D-penicillamine.

[ [ "D-penicillamine", "inhibition of hematopoiesis" ] ]

This article presents a case of an atypical localized cutaneous eruption with an unusual course and protracted resolution time associated with sorafenib therapy.

[ [ "sorafenib", "atypical localized cutaneous eruption" ] ]

2-CdA typically causes a long-lasting state of immunodeficiency and the profound influence of this drug on the immune system has raised questions concerning the emergence of secondary neoplasms after its use.

[ [ "2-CdA", "immunodeficiency" ], [ "2-CdA", "secondary neoplasms" ] ]

This unusual pattern of low-grade endometrial carcinoma adds to the spectrum of uterine neoplasia associated with tamoxifen therapy.

[ [ "tamoxifen", "low-grade endometrial carcinoma" ], [ "tamoxifen", "uterine neoplasia" ] ]

Two patients who developed decreased visual acuity after several months of ethambutol treatment for Mycobacterium avium-intracellulare infection had bitemporal visual field defects that suggested optic chiasm damage.

[ [ "ethambutol", "bitemporal visual field defects" ], [ "ethambutol", "decreased visual acuity" ] ]

Methotrexate is an effective but potentially toxic treatment for psoriasis.

[ [ "Methotrexate", "potentially toxic" ] ]

For patients who suffer from osteogenic sarcoma and have anaphylactic reactions to MTX, this desensitization protocol will allow these patients to continue with needed therapeutic or palliative chemotherapy.

[ [ "MTX", "anaphylactic reactions" ] ]

RESULTS: A 44-year-old man taking naproxen for chronic low back pain and a 20-year-old woman on oxaprozin for rheumatoid arthritis presented with tense bullae and cutaneous fragility on the face and the back of the hands.

[ [ "oxaprozin", "cutaneous fragility" ], [ "naproxen", "cutaneous fragility" ], [ "naproxen", "tense bullae" ], [ "oxaprozin", "tense bullae" ] ]

CONCLUSIONS: This is the second case report that describes gemcitabine-induced radiation recall in rectus abdominus muscles after gemcitabine-based radiation therapy.

[ [ "gemcitabine", "radiation recall" ] ]

Case report: mannitol nephrotoxicity syndrome: role of hemodialysis and postulate of mechanisms.

[ [ "mannitol", "nephrotoxicity syndrome" ] ]

Indinavir-associated nephrolithiasis and chronic interstitial nephritis were the only possible causes identified in this patient.

[ [ "Indinavir", "interstitial nephritis" ], [ "Indinavir", "nephrolithiasis" ] ]

We report the first case of IHA associated with cefuroxime administration.

[ [ "cefuroxime", "IHA" ] ]

The authors think that although lamivudine is widely used and well tolerated, it can cause ADRs, which are reversible after drug withdrawal.

[ [ "lamivudine", "ADRs" ] ]

Parenteral pyridoxine, the specific antidote for INH-induced refractory seizures, should be readily available in every emergency department in the areas similarly experiencing increasing trends of TB.

[ [ "INH", "refractory seizures" ] ]

Cephalosporins are most likely associated with Vitamin K deficiency.

[ [ "Cephalosporins", "Vitamin K deficiency" ] ]

PVT during chemotherapy in children is a rare event and appears to be closely related to intensive chemotherapy containing busulfan and to be associated with HVOD.

[ [ "busulfan", "HVOD" ], [ "busulfan", "PVT" ] ]

Occult quinine-induced thrombocytopenia.

[ [ "quinine", "thrombocytopenia" ] ]

These multiple overlapping factors probably lead to rhabdomyolysis in a minority of patients receiving vasopressin infusion.

[ [ "vasopressin", "rhabdomyolysis" ] ]

This case highlights the possible development of acute coronary syndrome as a side effect of Capecitabine therapy.

[ [ "Capecitabine", "acute coronary syndrome" ] ]

However, an association of Ritalin with glaucoma has been reported.

[ [ "Ritalin", "glaucoma" ] ]

We report 4 patients, 2 on methylphenidate and 2 on dextroamphetamine who presented with acral cyanosis, livedo reticularis, or Raynaud phenomenon.

[ [ "dextroamphetamine", "Raynaud phenomenon" ], [ "methylphenidate", "Raynaud phenomenon" ], [ "methylphenidate", "acral cyanosis" ], [ "dextroamphetamine", "acral cyanosis" ], [ "methylphenidate", "livedo reticularis" ], [ "dextroamphetamine", "livedo reticularis" ] ]

A drug interaction between zafirlukast and theophylline.

[ [ "zafirlukast", "drug interaction" ], [ "theophylline", "drug interaction" ] ]

In this paper, we report a case of severe hypercalcemia of immobilization in a 40-year-old hemodialyzed woman treated by cinacalcet HCl for a severe HPTH-II (PTH>1,000 pg/mL).

[ [ "cinacalcet HCl", "severe hypercalcemia" ] ]

CONCLUSIONS: Clarithromycin may be a cause of fulminant liver failure either alone or by inhibiting the metabolism of other drugs.

[ [ "Clarithromycin", "fulminant liver failure" ] ]

Sporadic rippling muscle disease unmasked by simvastatin.

[ [ "simvastatin", "Sporadic rippling muscle disease" ] ]

We report here a case of TEN after administration of ciprofloxacin.

[ [ "ciprofloxacin", "TEN" ] ]

Moreover, treatment with immunosuppressive drugs such as cyclosporine, cisplatin, tacrolimus, and interferon-alpha can induce a condition resembling RPLS.

[ [ "cisplatin", "RPLS" ], [ "tacrolimus", "RPLS" ], [ "cyclosporine", "RPLS" ], [ "interferon-alpha", "RPLS" ] ]

Therapy with IFN-beta has rarely been associated with the development of autoimmune disorders.

[ [ "IFN-beta", "autoimmune disorders" ] ]

OBJECTIVE: To report a case of severe apnea in an infant exposed to lamotrigine through breast-feeding.

[ [ "lamotrigine", "severe apnea" ] ]

CONCLUSION: Marked visual field constriction appears to be associated with vigabatrin therapy.

[ [ "vigabatrin", "visual field constriction" ] ]

Acute pancreatitis in a child with idiopathic ulcerative colitis on long-term 5-aminosalicylic acid therapy.

[ [ "5-aminosalicylic acid", "Acute pancreatitis" ] ]

CONCLUSION: Lipoid pneumonia as a result of mineral oil aspiration still occurs in the pediatric population.

[ [ "mineral oil", "Lipoid pneumonia" ] ]

CONCLUSIONS: Topical brimonidine may be associated with central nervous system depression in infants.

[ [ "brimonidine", "central nervous system depression" ] ]

It carries a well-known risk of neutropenia and agranulocytosis, which necessitates the immediate discontinuation of clozapine.

[ [ "clozapine", "agranulocytosis" ], [ "clozapine", "neutropenia" ] ]

BACKGROUND: Methotrexate (MTX) may induce liver damage, which in some psoriatics will lead to fibrosis or cirrhosis.

[ [ "MTX", "liver damage" ], [ "Methotrexate", "cirrhosis" ], [ "Methotrexate", "liver damage" ], [ "MTX", "cirrhosis" ], [ "Methotrexate", "fibrosis" ], [ "MTX", "fibrosis" ] ]

Anaphylaxis to intrathecal diamorphine.

[ [ "diamorphine", "Anaphylaxis" ] ]