harpreetmann/entity_extraction_ade · Datasets at Hugging Face

text stringlengths 22 455	pairs listlengths 1 24
Based on these findings, the patient was diagnosed with diabetes insipidus secondary to lithium therapy and was treated successfully with amiloride.	[ [ "lithium", "diabetes insipidus" ] ]
Mental nerve neuropathy as a result of hepatitis B vaccination.	[ [ "hepatitis B vaccination", "Mental nerve neuropathy" ] ]
Prick tests and intradermal tests with a series of dilutions of carboplatin and cisplatin were performed on three patients who had exhibited medium and severe hypersensitivity reactions to carboplatin.	[ [ "carboplatin", "severe hypersensitivity" ] ]
Possible induction of diabetes by treatment of hypertension with indapamide (with four case reports).	[ [ "indapamide", "diabetes" ] ]
The role of Adriamycin in the production of cardiotoxicity is reviewed.	[ [ "Adriamycin", "cardiotoxicity" ] ]
Growth and adrenal suppression in asthmatic children treated with high-dose fluticasone propionate.	[ [ "fluticasone propionate", "Growth and adrenal suppression" ] ]
Both patients developed hypoadrenalism while on o,p'-DDD and apparently adequate dexamethasone replacement therapy.	[ [ "o,p'-DDD", "hypoadrenalism" ] ]
A patient that received methadone for cancer-associated pain developed myoclonus as a side effect.	[ [ "methadone", "myoclonus" ] ]
In the present paper, we describe two patients with active UC who developed a severe systemic CMV infection during a treatment with an oral microemulsion form of cyclosporine.	[ [ "cyclosporine", "severe systemic CMV infection" ] ]
OBJECTIVE: To report a case of colchicine-induced myopathy in a teenager with familial Mediterranean fever (FMF).	[ [ "colchicine", "myopathy" ] ]
Though physicians treating large populations of patients with HIV are well aware of this complication, only one other report of nevirapine-associated SJS has been documented in the dermatology literature.	[ [ "nevirapine", "SJS" ] ]
The international literature regarding opportunistic infections after immunosuppressive therapy with alemtuzumab with particular attention on fungal infections has also been reviewed.	[ [ "alemtuzumab", "fungal infections" ], [ "alemtuzumab", "opportunistic infections" ] ]
It is concluded that 'cerebral atrophy' on CT scans may represent an accumulative effect of ACTH and that ACTH should be given with the utmost discretion, and in as low a dose as possible.	[ [ "ACTH", "cerebral atrophy" ] ]
To our knowledge, these cases represent the first reports of TDF-associated irreversible renal failure and rickets in pediatric patients.	[ [ "TDF", "irreversible renal failure" ], [ "TDF", "rickets" ] ]
Diphenylhydantoin apparently adversely affected both the clinical and biochemical parameters of the acute intermittent porphyria.	[ [ "Diphenylhydantoin", "acute intermittent porphyria" ] ]
We introduce a case of a sixty years old woman with several previous episodes of rhinitis, conjunctivitis and perspiration immediately after the administration of salmon calcitonin with nasal spray or intramuscular administration (Calsynar).	[ [ "calcitonin", "rhinitis" ], [ "calcitonin", "perspiration" ], [ "Calsynar", "conjunctivitis" ], [ "calcitonin", "conjunctivitis" ], [ "Calsynar", "rhinitis" ], [ "Calsynar", "perspiration" ] ]
Caution in longterm usage and early recognition of pentazocine toxicity as a neuromuscular complication are important in order to prevent irreversible drug-induced fibrous myopathy and localized neuropathy.	[ [ "pentazocine", "fibrous myopathy" ], [ "pentazocine", "neuromuscular complication" ], [ "pentazocine", "pentazocine toxicity" ], [ "pentazocine", "neuropathy" ] ]
A case is described of severe splenic hemorrhage and rupture which developed 3 h after completion of tPA infusion for suspected acute myocardial infarction.	[ [ "tPA", "severe splenic hemorrhage and rupture" ] ]
Coadministration of antidepressant agents such as nefazodone, or any other drug that inhibits the CYP3A4 isoenzyme subfamily, should be anticipated to interfere with tacrolimus metabolism.	[ [ "tacrolimus", "interfere with tacrolimus metabolism" ], [ "nefazodone", "interfere with tacrolimus metabolism" ] ]
Although dyspnea associated with verapamil administration has been reported, this is the first report of an elderly asymptomatic asthmatic patient with hypertension who developed an acute asthma attack following sustained-release verapamil administration.	[ [ "verapamil", "dyspnea" ], [ "verapamil", "acute asthma" ] ]
On the other hand, MTX-induced pneumonitis seems to be very rare in psoriatic arthritis (PsA).	[ [ "MTX", "pneumonitis" ] ]
Three patients with no history of asthma or allergy developed bronchospasm while taking propranolol for hypertension.	[ [ "propranolol", "bronchospasm" ] ]
Two infants developed hyperkalemia shortly after cessation of prolonged ACTH therapy for infantile spasms.	[ [ "ACTH", "hyperkalemia" ] ]
A review of the literature revealed two other cases of hepatic angiosarcoma in patients after long-term cyclophosphamide treatment.	[ [ "cyclophosphamide", "hepatic angiosarcoma" ] ]
Sustained monomorphic ventricular tachycardia after adenosine infusion.	[ [ "adenosine", "Sustained monomorphic ventricular tachycardia" ] ]
An episode of leukoencephalopathy is reported in a 13-year-old girl who, after standard radiotherapy for a posterior fossa medulloblastoma, received 8 treatments with a protocol containing a 4-hour infusion of 500 mg/m2 methotrexate and 12 mg intrathecal methotrexate.	[ [ "methotrexate", "leukoencephalopathy" ] ]
Alveolar-interstitial pneumopathy after gold-salts compounds administration, requiring mechanical ventilation.	[ [ "gold", "Alveolar-interstitial pneumopathy" ] ]
Disseminated tuberculous lesions post intravesical BCG therapy are rare but need to be identified and treated quickly.	[ [ "BCG", "Disseminated tuberculous lesions" ] ]
The literature is also reviewed for ARF associated with mannitol infusion in patients who received dialysis and those who did not receive dialysis; and the possible mechanism(s) of mannitol nephrotoxicity are discussed.	[ [ "mannitol", "nephrotoxicity" ], [ "mannitol", "ARF" ] ]
Propoxyphene-induced wide complex dysrhythmia responsive to sodium bicarbonate therapy has not been previously reported in the literature.	[ [ "Propoxyphene", "wide complex dysrhythmia" ] ]
Sixteen hours after the first administration of IFN, IFN was suspended by the symptoms of congestive heart failure (CHF).	[ [ "IFN", "CHF" ], [ "IFN", "congestive heart failure" ] ]
We report on a patient who developed acute rhabdomyolysis after taking cerivastatin.	[ [ "cerivastatin", "acute rhabdomyolysis" ] ]
Four cases of fat embolism are described in infants receiving prolonged intravenous infusion of fat (Intralipid 20%).	[ [ "Intralipid", "fat embolism" ] ]
We present the case of an adult Crohn's disease patient with a parvovirus B19 infection and leukopenia during long-term AZA therapy.	[ [ "AZA", "leukopenia" ] ]
Acute renal failure during lisinopril and losartan therapy for proteinuria.	[ [ "losartan", "Acute renal failure" ], [ "lisinopril", "Acute renal failure" ] ]
A 23-year-old woman with systemic lupus erythematosus had a severe hypersensitivity reaction to the drug ibuprofen.	[ [ "ibuprofen", "severe hypersensitivity reaction" ] ]
Life-threatening acute hyponatraemia induced by low dose cyclophosphamide and indomethacin.	[ [ "indomethacin", "acute hyponatraemia" ], [ "cyclophosphamide", "acute hyponatraemia" ] ]
Multifocal inflammatory leukoencephalopathy associated with levamisole therapy.	[ [ "levamisole", "Multifocal inflammatory leukoencephalopathy" ] ]
Pharmacokinetic determinants of 6-mercaptopurine myelotoxicity and therapeutic failure in children with acute lymphoblastic leukemia.	[ [ "6-mercaptopurine", "myelotoxicity" ] ]
A 32-year-old man with a family history of type 2 diabetes mellitus presented with circulatory collapse and deep coma after 9 days of treatment with perospirone hydrochloride, a recently developed atypical antipsychotic agent available only in Japan.	[ [ "perospirone hydrochloride", "circulatory collapse" ], [ "perospirone hydrochloride", "deep coma" ] ]
CONCLUSIONS: Topiramate may be associated with ciliochoroidal effusion with forward displacement of the lens-iris diaphragm and anterior chamber shallowing, resulting in acute myopia and angle-closure glaucoma.	[ [ "Topiramate", "angle-closure glaucoma" ], [ "Topiramate", "anterior chamber shallowing" ], [ "Topiramate", "displacement of the lens-iris diaphragm" ], [ "Topiramate", "acute myopia" ], [ "Topiramate", "ciliochoroidal effusion" ] ]
An adult male presented with central blindness after ingesting methanol.	[ [ "methanol", "central blindness" ] ]
Their parkinsonism improved on discontinuation of metoclopramide therapy.	[ [ "metoclopramide", "parkinsonism" ] ]
Delay of corneal wound healing in patients treated with colchicine.	[ [ "colchicine", "Delay of corneal wound healing" ] ]
Cutaneous reactions to propylthiouracil and methimazole occur in 3%-5% of adults.	[ [ "methimazole", "Cutaneous reactions" ], [ "propylthiouracil", "Cutaneous reactions" ] ]
To our knowledge, these cases are the first published reports of lovastatin-induced rhabdomyolysis associated with azithromycin and clarithromycin.	[ [ "lovastatin", "rhabdomyolysis" ], [ "clarithromycin", "rhabdomyolysis" ], [ "azithromycin", "rhabdomyolysis" ] ]
We present here a female patient who developed acute bilateral parotitis within minutes of i.v. enalaprilat injection and recovered within 24 hours of stopping the drug and with symptomatic treatment.	[ [ "enalaprilat", "acute bilateral parotitis" ] ]
CONCLUSIONS: This case describes the clinically significant increase of INR in an elderly patient after adding a chemotherapy regimen of levamisole and 5-FU to a previous regimen of warfarin alone.	[ [ "levamisole", "increase of INR" ], [ "5-FU", "increase of INR" ], [ "warfarin", "increase of INR" ] ]
In addition to disease refractoriness, rare instances of disease progression from chronic phase to blast crisis during imatinib therapy have recently been anecdotally reported.	[ [ "imatinib", "blast crisis" ] ]
Although no coagulation study was done and the Meckel's diverticulum is normally associated with bleeding, the particular intensity of the following hemorrhage may have been favored by metformin.	[ [ "metformin", "hemorrhage" ] ]
We describe a case of prolonged terbinafine-induced cholestatic liver disease.	[ [ "terbinafine", "cholestatic liver disease" ] ]
A 57-year-old man developed chronic, watery diarrhea four weeks after Helicobacter pylori eradication therapy including lansoprazole followed by lansoprazole monotherapy for gastroesophageal reflux disease.	[ [ "lansoprazole", "chronic, watery diarrhea" ] ]
Gynecomastia developed in two epileptic patients some months after the addition of oral fluoresone 750 mg daily to the phenobarbital and phenytoin already being administered.	[ [ "phenobarbital", "Gynecomastia" ], [ "fluoresone", "Gynecomastia" ], [ "phenytoin", "Gynecomastia" ] ]
Acute coronary syndromes can be associated with the infusion of rituximab.	[ [ "rituximab", "Acute coronary syndromes" ] ]
In this report we present four patients treated with a combination of different psychotropic drugs, in whom asterixis was triggered either by adding carbamazepine (CBZ) to a treatment regimen, or by increasing its dosage.	[ [ "CBZ", "asterixis" ], [ "carbamazepine", "asterixis" ] ]
Cardiomyopathy after widely separated courses of adriamycin exacerbated by actinomycin-D and mithramycin.	[ [ "adriamycin", "Cardiomyopathy" ], [ "mithramycin", "Cardiomyopathy" ], [ "actinomycin-D", "Cardiomyopathy" ] ]
Early recognition of hereditary motor and sensory neuropathy type 1 can avoid life-threatening vincristine neurotoxicity.	[ [ "vincristine", "life-threatening vincristine neurotoxicity" ] ]
Serotonin syndrome caused by selective serotonin reuptake-inhibitors-metoclopramide interaction.	[ [ "metoclopramide", "Serotonin syndrome" ] ]
Although this combination agent has been associated with a hypersensitivity syndrome involving cutaneous skin eruptions, pediatric cases of TMP-SMX-induced hepatotoxicity are rare.	[ [ "TMP-SMX", "cutaneous skin eruptions" ], [ "TMP-SMX", "hypersensitivity syndrome" ], [ "TMP-SMX", "hepatotoxicity" ] ]
Complications associated with primary and secondary perforation of the bladder following immediate instillations of epirubicin after transurethral resection of superficial urothelial tumours.	[ [ "epirubicin", "primary and secondary perforation of the bladder" ] ]
After having received gemcitabine on day 1 of the second course, the patient developed dry cough, subfebrile temperatures and dyspnea within 48 h.	[ [ "gemcitabine", "dyspnea" ], [ "gemcitabine", "dry cough" ], [ "gemcitabine", "subfebrile temperatures" ] ]
Nonoliguric acute renal failure after captopril therapy.	[ [ "captopril", "Nonoliguric acute renal failure" ] ]
RTA is one type of nephrotoxicity induced by FK506, and it is reversible in mild cases when appropriately treated.	[ [ "FK506", "RTA" ], [ "FK506", "nephrotoxicity" ] ]
Based on our findings, it is thus concluded that cisplatin may cause C. difficile colitis.	[ [ "cisplatin", "C. difficile colitis" ] ]
With the first cyclosporine dose, the patient complained of leg pain that was most severe during the cyclosporine infusion.	[ [ "cyclosporine", "leg pain" ] ]
Exacerbation of anthracycline-induced early chronic cardiomyopathy with ATRA: role of B-type natriuretic peptide as an indicator of cardiac dysfunction.	[ [ "anthracycline", "early chronic cardiomyopathy" ] ]
Therefore, clinicians should pay close attention to possible onset of RD in patients with multiple risk factors for TD, even when SDA therapy is used.	[ [ "SDA", "RD" ] ]
Isoniazid associated, painful, bilateral gynaecomastia.	[ [ "Isoniazid", "bilateral gynaecomastia" ] ]
Ciprofloxacin-induced psychosis.	[ [ "Ciprofloxacin", "psychosis" ] ]
Two of these patients, who also received the anti-emetic prochlorperazine, lost consciousness for 48-72 h and then fully recovered.	[ [ "prochlorperazine", "lost consciousness" ] ]
Disulfiram-like reactions with newer cephalosporins: cefmenoxime.	[ [ "cefmenoxime", "Disulfiram-like reactions" ] ]
Multiple syncopal episodes started to occur during thalidomide treatment, and a Holter electrocardiogram showed multiple abnormalities, with an episode of sustained ventricular tachycardia.	[ [ "thalidomide", "sustained ventricular tachycardia" ], [ "thalidomide", "Multiple syncopal episodes" ] ]
A 17-year-old female patient who had been taking oral minocycline (50 mg twice daily) for 3 weeks for acne developed an eruption that progressed to an exfoliative dermatitis.	[ [ "minocycline", "exfoliative dermatitis" ], [ "minocycline", "eruption" ] ]
As these cases revealed, close monitoring of blood chemistry is mandatory after starting spironolactone, and patients should be advised to stop spironolactone immediately if diarrhoea develops.	[ [ "spironolactone", "diarrhoea" ] ]
In the first patient, two episodes of ventricular tachycardia requiring cardioversion occurred in close temporal sequence with administering bretylium.	[ [ "bretylium", "ventricular tachycardia" ] ]
Captopril-induced pulmonary infiltrates with eosinophilia in an infant with congenital heart disease.	[ [ "Captopril", "pulmonary infiltrates with eosinophilia" ] ]
Sodium valproate and carbamazepine, antiepileptic drugs that are associated with a relatively low rate of adverse cutaneous reactions, should be added to the growing list of drugs that produce psoriasiform eruptions.	[ [ "carbamazepine", "psoriasiform eruptions" ], [ "Sodium valproate", "psoriasiform eruptions" ] ]
We report a case of seizure associated with L-asparaginase therapy but no evidence of hemorrhagic or thrombotic cerebrovascular events.	[ [ "L-asparaginase", "seizure" ] ]
Case 2, a 29-year-old woman, developed bilateral optic neuritis combined with numbness of the lower extremities as well as bowel and bladder dysfunction after a 22-month use of recombinant interferon alpha-2b for chronic myelogenous leukemia.	[ [ "recombinant interferon alpha-2b", "bilateral optic neuritis" ], [ "recombinant interferon alpha-2b", "bowel and bladder dysfunction" ], [ "recombinant interferon alpha-2b", "numbness of the lower extremities" ] ]
Two patients treated with 5-fluorouracil (5-FU) for disseminated adenocarcinoma of the colon developed cerebellar dysfunction typical of 5-FU neurotoxicity.	[ [ "5-FU", "neurotoxicity" ], [ "5-FU", "cerebellar dysfunction" ], [ "5-fluorouracil", "neurotoxicity" ], [ "5-fluorouracil", "cerebellar dysfunction" ] ]
Masculinization of a female fetus occurred in 5 of 39 (12.8%) exposed to norethisterone; all were cases of clitoral hypertrophy not requiring surgical treatment.	[ [ "norethisterone", "Masculinization of a female fetus" ], [ "norethisterone", "clitoral hypertrophy" ] ]
A typical case of dextran-40 associated acute renal failure is presented.	[ [ "dextran-40", "acute renal failure" ] ]
An unusual case of Ecstasy poisoning.	[ [ "Ecstasy", "Ecstasy poisoning" ] ]
Persistent light reactivity from systemic quinine.	[ [ "quinine", "Persistent light reactivity" ] ]
A case of allopurinol hypersensitivity, possibly the first in a black African, is reported.	[ [ "allopurinol", "hypersensitivity" ] ]
RESULTS: A male and a female patient with spasticity treated with intrathecal baclofen were recognized to have sexual dysfunction side effects from treatment.	[ [ "baclofen", "sexual dysfunction" ] ]
AIM: Report of a case of a woman patient who developed celiac disease after pegylated interferon alpha-2a and ribavirin use for chronic hepatitis C.	[ [ "pegylated interferon alpha-2a", "celiac disease" ], [ "ribavirin", "celiac disease" ] ]
OBJECTIVE: To report the occurrence of acute cytolytic hepatitis in a patient exposed to pulse itraconazole therapy for 24 weeks and provide a concise review of the literature on cases of itraconazole-induced hepatitis.	[ [ "itraconazole", "hepatitis" ], [ "itraconazole", "acute cytolytic hepatitis" ] ]
We describe a heroin abuser in whom clinical and laboratory manifestations of acute hepatitis B and C appeared a few days after the insertion of a subcutaneous naltrexone implant.	[ [ "naltrexone", "acute hepatitis B and C" ] ]
CONCLUSIONS: Patients receiving intravitreal injections of bevacizumab should be evaluated for potential systemic risk factors such as carotid insufficiency, coagulopathy and poorly controlled diabetes mellitus.	[ [ "bevacizumab", "carotid insufficiency" ], [ "bevacizumab", "coagulopathy" ], [ "bevacizumab", "poorly controlled diabetes mellitus" ] ]
Cardiorespiratory toxicity due to miconazole.	[ [ "miconazole", "Cardiorespiratory toxicity" ] ]
His impaired memory was found to be due to the atenolol he was on and he made a complete recovery on withdrawing the beta-blocker.	[ [ "atenolol", "impaired memory" ] ]
There is documentation of ocular toxicity with ethambutol when administered at dosages generally pronounced as being safe.	[ [ "ethambutol", "ocular toxicity" ] ]
Acute sensorineural hearing loss following intravenous ketoralac administration.	[ [ "ketoralac", "Acute sensorineural hearing loss" ] ]
CONCLUSIONS: Clinicians should be aware of this adverse reaction when facing similar complex neurologic symptoms in patients who are receiving the antibiotic treatment described here, especially vancomycin.	[ [ "vancomycin", "neurologic symptoms" ] ]
A patient with monocular open-angle glaucoma had trichiasis, a condition associated with the use of a prostaglandin analog.	[ [ "prostaglandin", "trichiasis" ] ]
Fulminant hepatitis with severe lactate acidosis in HIV-infected patients on didanosine therapy.	[ [ "didanosine", "Fulminant hepatitis" ], [ "didanosine", "severe lactate acidosis" ] ]
Findings on discontinuation and rechallenge supported the assumption that the hair loss was a side effect of the paroxetine.	[ [ "paroxetine", "hair loss" ] ]
RESULTS: A 34-year-old man acquired visual field defects and severe vision loss in both eyes after intravitreal injection of triamcinolone for diabetic macular edema.	[ [ "triamcinolone", "visual field defects" ], [ "triamcinolone", "severe vision loss" ] ]
INTERVENTIONS AND RESULTS: Cardiac complications were observed in five pediatric patients who received between 4.6 and 40.8 mg/kg/d of amphotericin B.	[ [ "amphotericin B", "Cardiac complications" ] ]

Based on these findings, the patient was diagnosed with diabetes insipidus secondary to lithium therapy and was treated successfully with amiloride.

[ [ "lithium", "diabetes insipidus" ] ]

Mental nerve neuropathy as a result of hepatitis B vaccination.

[ [ "hepatitis B vaccination", "Mental nerve neuropathy" ] ]

Prick tests and intradermal tests with a series of dilutions of carboplatin and cisplatin were performed on three patients who had exhibited medium and severe hypersensitivity reactions to carboplatin.

[ [ "carboplatin", "severe hypersensitivity" ] ]

Possible induction of diabetes by treatment of hypertension with indapamide (with four case reports).

[ [ "indapamide", "diabetes" ] ]

The role of Adriamycin in the production of cardiotoxicity is reviewed.

[ [ "Adriamycin", "cardiotoxicity" ] ]

Growth and adrenal suppression in asthmatic children treated with high-dose fluticasone propionate.

[ [ "fluticasone propionate", "Growth and adrenal suppression" ] ]

Both patients developed hypoadrenalism while on o,p'-DDD and apparently adequate dexamethasone replacement therapy.

[ [ "o,p'-DDD", "hypoadrenalism" ] ]

A patient that received methadone for cancer-associated pain developed myoclonus as a side effect.

[ [ "methadone", "myoclonus" ] ]

In the present paper, we describe two patients with active UC who developed a severe systemic CMV infection during a treatment with an oral microemulsion form of cyclosporine.

[ [ "cyclosporine", "severe systemic CMV infection" ] ]

OBJECTIVE: To report a case of colchicine-induced myopathy in a teenager with familial Mediterranean fever (FMF).

[ [ "colchicine", "myopathy" ] ]

Though physicians treating large populations of patients with HIV are well aware of this complication, only one other report of nevirapine-associated SJS has been documented in the dermatology literature.

[ [ "nevirapine", "SJS" ] ]

The international literature regarding opportunistic infections after immunosuppressive therapy with alemtuzumab with particular attention on fungal infections has also been reviewed.

[ [ "alemtuzumab", "fungal infections" ], [ "alemtuzumab", "opportunistic infections" ] ]

It is concluded that 'cerebral atrophy' on CT scans may represent an accumulative effect of ACTH and that ACTH should be given with the utmost discretion, and in as low a dose as possible.

[ [ "ACTH", "cerebral atrophy" ] ]

To our knowledge, these cases represent the first reports of TDF-associated irreversible renal failure and rickets in pediatric patients.

[ [ "TDF", "irreversible renal failure" ], [ "TDF", "rickets" ] ]

Diphenylhydantoin apparently adversely affected both the clinical and biochemical parameters of the acute intermittent porphyria.

[ [ "Diphenylhydantoin", "acute intermittent porphyria" ] ]

We introduce a case of a sixty years old woman with several previous episodes of rhinitis, conjunctivitis and perspiration immediately after the administration of salmon calcitonin with nasal spray or intramuscular administration (Calsynar).

[ [ "calcitonin", "rhinitis" ], [ "calcitonin", "perspiration" ], [ "Calsynar", "conjunctivitis" ], [ "calcitonin", "conjunctivitis" ], [ "Calsynar", "rhinitis" ], [ "Calsynar", "perspiration" ] ]

Caution in longterm usage and early recognition of pentazocine toxicity as a neuromuscular complication are important in order to prevent irreversible drug-induced fibrous myopathy and localized neuropathy.

[ [ "pentazocine", "fibrous myopathy" ], [ "pentazocine", "neuromuscular complication" ], [ "pentazocine", "pentazocine toxicity" ], [ "pentazocine", "neuropathy" ] ]

A case is described of severe splenic hemorrhage and rupture which developed 3 h after completion of tPA infusion for suspected acute myocardial infarction.

[ [ "tPA", "severe splenic hemorrhage and rupture" ] ]

Coadministration of antidepressant agents such as nefazodone, or any other drug that inhibits the CYP3A4 isoenzyme subfamily, should be anticipated to interfere with tacrolimus metabolism.

[ [ "tacrolimus", "interfere with tacrolimus metabolism" ], [ "nefazodone", "interfere with tacrolimus metabolism" ] ]

Although dyspnea associated with verapamil administration has been reported, this is the first report of an elderly asymptomatic asthmatic patient with hypertension who developed an acute asthma attack following sustained-release verapamil administration.

[ [ "verapamil", "dyspnea" ], [ "verapamil", "acute asthma" ] ]

On the other hand, MTX-induced pneumonitis seems to be very rare in psoriatic arthritis (PsA).

[ [ "MTX", "pneumonitis" ] ]

Three patients with no history of asthma or allergy developed bronchospasm while taking propranolol for hypertension.

[ [ "propranolol", "bronchospasm" ] ]

Two infants developed hyperkalemia shortly after cessation of prolonged ACTH therapy for infantile spasms.

[ [ "ACTH", "hyperkalemia" ] ]

A review of the literature revealed two other cases of hepatic angiosarcoma in patients after long-term cyclophosphamide treatment.

[ [ "cyclophosphamide", "hepatic angiosarcoma" ] ]

Sustained monomorphic ventricular tachycardia after adenosine infusion.

[ [ "adenosine", "Sustained monomorphic ventricular tachycardia" ] ]

An episode of leukoencephalopathy is reported in a 13-year-old girl who, after standard radiotherapy for a posterior fossa medulloblastoma, received 8 treatments with a protocol containing a 4-hour infusion of 500 mg/m2 methotrexate and 12 mg intrathecal methotrexate.

[ [ "methotrexate", "leukoencephalopathy" ] ]

Alveolar-interstitial pneumopathy after gold-salts compounds administration, requiring mechanical ventilation.

[ [ "gold", "Alveolar-interstitial pneumopathy" ] ]

Disseminated tuberculous lesions post intravesical BCG therapy are rare but need to be identified and treated quickly.

[ [ "BCG", "Disseminated tuberculous lesions" ] ]

The literature is also reviewed for ARF associated with mannitol infusion in patients who received dialysis and those who did not receive dialysis; and the possible mechanism(s) of mannitol nephrotoxicity are discussed.

[ [ "mannitol", "nephrotoxicity" ], [ "mannitol", "ARF" ] ]

Propoxyphene-induced wide complex dysrhythmia responsive to sodium bicarbonate therapy has not been previously reported in the literature.

[ [ "Propoxyphene", "wide complex dysrhythmia" ] ]

Sixteen hours after the first administration of IFN, IFN was suspended by the symptoms of congestive heart failure (CHF).

[ [ "IFN", "CHF" ], [ "IFN", "congestive heart failure" ] ]

We report on a patient who developed acute rhabdomyolysis after taking cerivastatin.

[ [ "cerivastatin", "acute rhabdomyolysis" ] ]

Four cases of fat embolism are described in infants receiving prolonged intravenous infusion of fat (Intralipid 20%).

[ [ "Intralipid", "fat embolism" ] ]

We present the case of an adult Crohn's disease patient with a parvovirus B19 infection and leukopenia during long-term AZA therapy.

[ [ "AZA", "leukopenia" ] ]

Acute renal failure during lisinopril and losartan therapy for proteinuria.

[ [ "losartan", "Acute renal failure" ], [ "lisinopril", "Acute renal failure" ] ]

A 23-year-old woman with systemic lupus erythematosus had a severe hypersensitivity reaction to the drug ibuprofen.

[ [ "ibuprofen", "severe hypersensitivity reaction" ] ]

Life-threatening acute hyponatraemia induced by low dose cyclophosphamide and indomethacin.

[ [ "indomethacin", "acute hyponatraemia" ], [ "cyclophosphamide", "acute hyponatraemia" ] ]

Multifocal inflammatory leukoencephalopathy associated with levamisole therapy.

[ [ "levamisole", "Multifocal inflammatory leukoencephalopathy" ] ]

Pharmacokinetic determinants of 6-mercaptopurine myelotoxicity and therapeutic failure in children with acute lymphoblastic leukemia.

[ [ "6-mercaptopurine", "myelotoxicity" ] ]

A 32-year-old man with a family history of type 2 diabetes mellitus presented with circulatory collapse and deep coma after 9 days of treatment with perospirone hydrochloride, a recently developed atypical antipsychotic agent available only in Japan.

[ [ "perospirone hydrochloride", "circulatory collapse" ], [ "perospirone hydrochloride", "deep coma" ] ]

CONCLUSIONS: Topiramate may be associated with ciliochoroidal effusion with forward displacement of the lens-iris diaphragm and anterior chamber shallowing, resulting in acute myopia and angle-closure glaucoma.

[ [ "Topiramate", "angle-closure glaucoma" ], [ "Topiramate", "anterior chamber shallowing" ], [ "Topiramate", "displacement of the lens-iris diaphragm" ], [ "Topiramate", "acute myopia" ], [ "Topiramate", "ciliochoroidal effusion" ] ]

An adult male presented with central blindness after ingesting methanol.

[ [ "methanol", "central blindness" ] ]

Their parkinsonism improved on discontinuation of metoclopramide therapy.

[ [ "metoclopramide", "parkinsonism" ] ]

Delay of corneal wound healing in patients treated with colchicine.

[ [ "colchicine", "Delay of corneal wound healing" ] ]

Cutaneous reactions to propylthiouracil and methimazole occur in 3%-5% of adults.

[ [ "methimazole", "Cutaneous reactions" ], [ "propylthiouracil", "Cutaneous reactions" ] ]

To our knowledge, these cases are the first published reports of lovastatin-induced rhabdomyolysis associated with azithromycin and clarithromycin.

[ [ "lovastatin", "rhabdomyolysis" ], [ "clarithromycin", "rhabdomyolysis" ], [ "azithromycin", "rhabdomyolysis" ] ]

We present here a female patient who developed acute bilateral parotitis within minutes of i.v. enalaprilat injection and recovered within 24 hours of stopping the drug and with symptomatic treatment.

[ [ "enalaprilat", "acute bilateral parotitis" ] ]

CONCLUSIONS: This case describes the clinically significant increase of INR in an elderly patient after adding a chemotherapy regimen of levamisole and 5-FU to a previous regimen of warfarin alone.

[ [ "levamisole", "increase of INR" ], [ "5-FU", "increase of INR" ], [ "warfarin", "increase of INR" ] ]

In addition to disease refractoriness, rare instances of disease progression from chronic phase to blast crisis during imatinib therapy have recently been anecdotally reported.

[ [ "imatinib", "blast crisis" ] ]

Although no coagulation study was done and the Meckel's diverticulum is normally associated with bleeding, the particular intensity of the following hemorrhage may have been favored by metformin.

[ [ "metformin", "hemorrhage" ] ]

We describe a case of prolonged terbinafine-induced cholestatic liver disease.

[ [ "terbinafine", "cholestatic liver disease" ] ]

A 57-year-old man developed chronic, watery diarrhea four weeks after Helicobacter pylori eradication therapy including lansoprazole followed by lansoprazole monotherapy for gastroesophageal reflux disease.

[ [ "lansoprazole", "chronic, watery diarrhea" ] ]

Gynecomastia developed in two epileptic patients some months after the addition of oral fluoresone 750 mg daily to the phenobarbital and phenytoin already being administered.

[ [ "phenobarbital", "Gynecomastia" ], [ "fluoresone", "Gynecomastia" ], [ "phenytoin", "Gynecomastia" ] ]

Acute coronary syndromes can be associated with the infusion of rituximab.

[ [ "rituximab", "Acute coronary syndromes" ] ]

In this report we present four patients treated with a combination of different psychotropic drugs, in whom asterixis was triggered either by adding carbamazepine (CBZ) to a treatment regimen, or by increasing its dosage.

[ [ "CBZ", "asterixis" ], [ "carbamazepine", "asterixis" ] ]

Cardiomyopathy after widely separated courses of adriamycin exacerbated by actinomycin-D and mithramycin.

[ [ "adriamycin", "Cardiomyopathy" ], [ "mithramycin", "Cardiomyopathy" ], [ "actinomycin-D", "Cardiomyopathy" ] ]

Early recognition of hereditary motor and sensory neuropathy type 1 can avoid life-threatening vincristine neurotoxicity.

[ [ "vincristine", "life-threatening vincristine neurotoxicity" ] ]

Serotonin syndrome caused by selective serotonin reuptake-inhibitors-metoclopramide interaction.

[ [ "metoclopramide", "Serotonin syndrome" ] ]

Although this combination agent has been associated with a hypersensitivity syndrome involving cutaneous skin eruptions, pediatric cases of TMP-SMX-induced hepatotoxicity are rare.

[ [ "TMP-SMX", "cutaneous skin eruptions" ], [ "TMP-SMX", "hypersensitivity syndrome" ], [ "TMP-SMX", "hepatotoxicity" ] ]

Complications associated with primary and secondary perforation of the bladder following immediate instillations of epirubicin after transurethral resection of superficial urothelial tumours.

[ [ "epirubicin", "primary and secondary perforation of the bladder" ] ]

After having received gemcitabine on day 1 of the second course, the patient developed dry cough, subfebrile temperatures and dyspnea within 48 h.

[ [ "gemcitabine", "dyspnea" ], [ "gemcitabine", "dry cough" ], [ "gemcitabine", "subfebrile temperatures" ] ]

Nonoliguric acute renal failure after captopril therapy.

[ [ "captopril", "Nonoliguric acute renal failure" ] ]

RTA is one type of nephrotoxicity induced by FK506, and it is reversible in mild cases when appropriately treated.

[ [ "FK506", "RTA" ], [ "FK506", "nephrotoxicity" ] ]

Based on our findings, it is thus concluded that cisplatin may cause C. difficile colitis.

[ [ "cisplatin", "C. difficile colitis" ] ]

With the first cyclosporine dose, the patient complained of leg pain that was most severe during the cyclosporine infusion.

[ [ "cyclosporine", "leg pain" ] ]

Exacerbation of anthracycline-induced early chronic cardiomyopathy with ATRA: role of B-type natriuretic peptide as an indicator of cardiac dysfunction.

[ [ "anthracycline", "early chronic cardiomyopathy" ] ]

Therefore, clinicians should pay close attention to possible onset of RD in patients with multiple risk factors for TD, even when SDA therapy is used.

[ [ "SDA", "RD" ] ]

Isoniazid associated, painful, bilateral gynaecomastia.

[ [ "Isoniazid", "bilateral gynaecomastia" ] ]

Ciprofloxacin-induced psychosis.

[ [ "Ciprofloxacin", "psychosis" ] ]

Two of these patients, who also received the anti-emetic prochlorperazine, lost consciousness for 48-72 h and then fully recovered.

[ [ "prochlorperazine", "lost consciousness" ] ]

Disulfiram-like reactions with newer cephalosporins: cefmenoxime.

[ [ "cefmenoxime", "Disulfiram-like reactions" ] ]

Multiple syncopal episodes started to occur during thalidomide treatment, and a Holter electrocardiogram showed multiple abnormalities, with an episode of sustained ventricular tachycardia.

[ [ "thalidomide", "sustained ventricular tachycardia" ], [ "thalidomide", "Multiple syncopal episodes" ] ]

A 17-year-old female patient who had been taking oral minocycline (50 mg twice daily) for 3 weeks for acne developed an eruption that progressed to an exfoliative dermatitis.

[ [ "minocycline", "exfoliative dermatitis" ], [ "minocycline", "eruption" ] ]

As these cases revealed, close monitoring of blood chemistry is mandatory after starting spironolactone, and patients should be advised to stop spironolactone immediately if diarrhoea develops.

[ [ "spironolactone", "diarrhoea" ] ]

In the first patient, two episodes of ventricular tachycardia requiring cardioversion occurred in close temporal sequence with administering bretylium.

[ [ "bretylium", "ventricular tachycardia" ] ]

Captopril-induced pulmonary infiltrates with eosinophilia in an infant with congenital heart disease.

[ [ "Captopril", "pulmonary infiltrates with eosinophilia" ] ]

Sodium valproate and carbamazepine, antiepileptic drugs that are associated with a relatively low rate of adverse cutaneous reactions, should be added to the growing list of drugs that produce psoriasiform eruptions.

[ [ "carbamazepine", "psoriasiform eruptions" ], [ "Sodium valproate", "psoriasiform eruptions" ] ]

We report a case of seizure associated with L-asparaginase therapy but no evidence of hemorrhagic or thrombotic cerebrovascular events.

[ [ "L-asparaginase", "seizure" ] ]

Case 2, a 29-year-old woman, developed bilateral optic neuritis combined with numbness of the lower extremities as well as bowel and bladder dysfunction after a 22-month use of recombinant interferon alpha-2b for chronic myelogenous leukemia.

[ [ "recombinant interferon alpha-2b", "bilateral optic neuritis" ], [ "recombinant interferon alpha-2b", "bowel and bladder dysfunction" ], [ "recombinant interferon alpha-2b", "numbness of the lower extremities" ] ]

Two patients treated with 5-fluorouracil (5-FU) for disseminated adenocarcinoma of the colon developed cerebellar dysfunction typical of 5-FU neurotoxicity.

[ [ "5-FU", "neurotoxicity" ], [ "5-FU", "cerebellar dysfunction" ], [ "5-fluorouracil", "neurotoxicity" ], [ "5-fluorouracil", "cerebellar dysfunction" ] ]

Masculinization of a female fetus occurred in 5 of 39 (12.8%) exposed to norethisterone; all were cases of clitoral hypertrophy not requiring surgical treatment.

[ [ "norethisterone", "Masculinization of a female fetus" ], [ "norethisterone", "clitoral hypertrophy" ] ]

A typical case of dextran-40 associated acute renal failure is presented.

[ [ "dextran-40", "acute renal failure" ] ]

An unusual case of Ecstasy poisoning.

[ [ "Ecstasy", "Ecstasy poisoning" ] ]

Persistent light reactivity from systemic quinine.

[ [ "quinine", "Persistent light reactivity" ] ]

A case of allopurinol hypersensitivity, possibly the first in a black African, is reported.

[ [ "allopurinol", "hypersensitivity" ] ]

RESULTS: A male and a female patient with spasticity treated with intrathecal baclofen were recognized to have sexual dysfunction side effects from treatment.

[ [ "baclofen", "sexual dysfunction" ] ]

AIM: Report of a case of a woman patient who developed celiac disease after pegylated interferon alpha-2a and ribavirin use for chronic hepatitis C.

[ [ "pegylated interferon alpha-2a", "celiac disease" ], [ "ribavirin", "celiac disease" ] ]

OBJECTIVE: To report the occurrence of acute cytolytic hepatitis in a patient exposed to pulse itraconazole therapy for 24 weeks and provide a concise review of the literature on cases of itraconazole-induced hepatitis.

[ [ "itraconazole", "hepatitis" ], [ "itraconazole", "acute cytolytic hepatitis" ] ]

We describe a heroin abuser in whom clinical and laboratory manifestations of acute hepatitis B and C appeared a few days after the insertion of a subcutaneous naltrexone implant.

[ [ "naltrexone", "acute hepatitis B and C" ] ]

CONCLUSIONS: Patients receiving intravitreal injections of bevacizumab should be evaluated for potential systemic risk factors such as carotid insufficiency, coagulopathy and poorly controlled diabetes mellitus.

[ [ "bevacizumab", "carotid insufficiency" ], [ "bevacizumab", "coagulopathy" ], [ "bevacizumab", "poorly controlled diabetes mellitus" ] ]

Cardiorespiratory toxicity due to miconazole.

[ [ "miconazole", "Cardiorespiratory toxicity" ] ]

His impaired memory was found to be due to the atenolol he was on and he made a complete recovery on withdrawing the beta-blocker.

[ [ "atenolol", "impaired memory" ] ]

There is documentation of ocular toxicity with ethambutol when administered at dosages generally pronounced as being safe.

[ [ "ethambutol", "ocular toxicity" ] ]

Acute sensorineural hearing loss following intravenous ketoralac administration.

[ [ "ketoralac", "Acute sensorineural hearing loss" ] ]

CONCLUSIONS: Clinicians should be aware of this adverse reaction when facing similar complex neurologic symptoms in patients who are receiving the antibiotic treatment described here, especially vancomycin.

[ [ "vancomycin", "neurologic symptoms" ] ]

A patient with monocular open-angle glaucoma had trichiasis, a condition associated with the use of a prostaglandin analog.

[ [ "prostaglandin", "trichiasis" ] ]

Fulminant hepatitis with severe lactate acidosis in HIV-infected patients on didanosine therapy.

[ [ "didanosine", "Fulminant hepatitis" ], [ "didanosine", "severe lactate acidosis" ] ]

Findings on discontinuation and rechallenge supported the assumption that the hair loss was a side effect of the paroxetine.

[ [ "paroxetine", "hair loss" ] ]

RESULTS: A 34-year-old man acquired visual field defects and severe vision loss in both eyes after intravitreal injection of triamcinolone for diabetic macular edema.

[ [ "triamcinolone", "visual field defects" ], [ "triamcinolone", "severe vision loss" ] ]

INTERVENTIONS AND RESULTS: Cardiac complications were observed in five pediatric patients who received between 4.6 and 40.8 mg/kg/d of amphotericin B.

[ [ "amphotericin B", "Cardiac complications" ] ]