harpreetmann/entity_extraction_ade · Datasets at Hugging Face

text stringlengths 22 455	pairs listlengths 1 24
Temozolomide-induced desquamative skin rash in a patient with metastatic melanoma.	[ [ "Temozolomide", "desquamative skin rash" ] ]
Flucytosine-associated diarrhea has been previously described in 6%-10% of patients receiving the drug.	[ [ "Flucytosine", "diarrhea" ] ]
Gemcitabine-induced rectus abdominus radiation recall.	[ [ "Gemcitabine", "rectus abdominus radiation recall" ] ]
Vasomotor reactions after gold sodium thiomalate are well recognized.	[ [ "gold sodium thiomalate", "Vasomotor reactions" ] ]
OBJECTIVE: To describe a case of sertraline-induced rhabdomyolysis in an elderly patient with dementia and comorbidities.	[ [ "sertraline", "rhabdomyolysis" ] ]
CASE SUMMARY: Two children with attention deficit disorder treated with methylphenidate as a simple drug developed fixed drug eruption of the scrotum.	[ [ "methylphenidate", "fixed drug eruption of the scrotum" ] ]
The medical examiner's report indicated death caused by fluoxetine toxicity.	[ [ "fluoxetine", "death" ], [ "fluoxetine", "fluoxetine toxicity" ] ]
We report a case of noncardiogenic pulmonary edema developed after therapeutic trial of EO as sclerosing agent for esophageal varix.	[ [ "EO", "noncardiogenic pulmonary edema" ] ]
Methotrexate may rarely provoke serositis, even with low doses and after just a few weeks of therapy.	[ [ "Methotrexate", "serositis" ] ]
We describe in detail the first U.S. case report, of a 4(1/2)-year-old boy who experienced angioedema during treatment with oxcarbazepine.	[ [ "oxcarbazepine", "angioedema" ] ]
Aluminum intoxication, along with other factors, was considered to be the cause of TC development.	[ [ "Aluminum", "Aluminum intoxication" ], [ "Aluminum", "TC" ] ]
Adult respiratory distress syndrome after treatment with pegylated interferon alpha-2a and ribavirin.	[ [ "pegylated interferon alpha-2a", "Adult respiratory distress syndrome" ], [ "ribavirin", "Adult respiratory distress syndrome" ] ]
Treatment of carbimazole-induced agranulocytosis and sepsis with granulocyte colony stimulating factor.	[ [ "carbimazole", "agranulocytosis" ], [ "carbimazole", "sepsis" ] ]
We describe a patient with metastatic prostate cancer who developed nonoliguric renal failure during treatment with suramin.	[ [ "suramin", "nonoliguric renal failure" ] ]
High-dose phosphate treatment leads to hypokalemia in hypophosphatemic osteomalacia.	[ [ "phosphate", "hypokalemia" ] ]
In this case report, we present clinical and laboratory findings of a case with chronic hepatitis B that developed acute dystonia soon after the first dose of pegylated interferon alpha.	[ [ "pegylated interferon alpha", "acute dystonia" ] ]
The use of pamidronate for hypercalcemia secondary to acute vitamin D intoxication.	[ [ "vitamin D", "vitamin D intoxication" ] ]
CONCLUSIONS: Itraconazole-induced liver injury presents with a cholestatic pattern of injury with damage to the interlobular bile ducts, possibly leading to ductopenia.	[ [ "Itraconazole", "damage to the interlobular bile ducts" ], [ "Itraconazole", "liver injury" ], [ "Itraconazole", "ductopenia" ], [ "Itraconazole", "cholestatic pattern of injury" ] ]
The frequency and relationship of granulocytopenia caused by sustained-release procainamide in patients with tachyarrhythmias are briefly discussed, and prior reported cases are reviewed.	[ [ "procainamide", "granulocytopenia" ] ]
Toxic hepatitis due to combination therapy with methotrexate and etretinate in psoriasis.	[ [ "methotrexate", "Toxic hepatitis" ], [ "etretinate", "Toxic hepatitis" ] ]
An obese patient, not diabetic, treated with metformin for some weeks, was referred to us with severe inferior digestive hemorrhage, diagnosed with Meckel's diverticulum.	[ [ "metformin", "severe inferior digestive hemorrhage" ] ]
Temsirolimus-induced glomerulopathy.	[ [ "Temsirolimus", "glomerulopathy" ] ]
Escape atrial complexes, which occurred following junctional premature complexes, failed to initiate tachycardia in the control state but tachycardia was always reinitiated by an identical escape sequence after procainamide.	[ [ "procainamide", "tachycardia" ] ]
No explanation for this delay was found, other than the possibility that magnesium sulfate treatment impeded lactogenesis.	[ [ "magnesium sulfate", "impeded lactogenesis" ] ]
Lithium neurotoxicity should be considered in Creutzfeldt-Jakob disease differential diagnosis, serial electroencephalograms being the most valuable.	[ [ "Lithium", "Lithium neurotoxicity" ], [ "Lithium", "Creutzfeldt-Jakob disease" ] ]
A case of acute cardiomyopathy and pericarditis associated with methylphenidate.	[ [ "methylphenidate", "pericarditis" ], [ "methylphenidate", "acute cardiomyopathy" ] ]
Oral intake and acarbose were withheld and the ileus spontaneously resolved after 2 days.	[ [ "acarbose", "ileus" ] ]
Anaphylactic reaction to oral prednisone: a case report and review of the literature.	[ [ "prednisone", "Anaphylactic reaction" ] ]
Biomicroscopy revealed amiodarone corneal deposits.	[ [ "amiodarone", "corneal deposits" ] ]
OBJECTIVE: To describe a patient with asymptomatic bronchial asthma and hypertension who developed an acute asthma attack after receiving sustained-release verapamil.	[ [ "verapamil", "acute asthma" ] ]
While on a maximal dose of phenylephrine she developed prominent positive U waves, which disappeared with the cessation of the drug.	[ [ "phenylephrine", "positive U waves" ] ]
Thalidomide neuropathy in childhood.	[ [ "Thalidomide", "neuropathy" ] ]
We report a case of a 64-year-old man with secondary adrenocortical insufficiency who has been on a chronic transdermal fentanyl treatment because of sciatic pain syndrome.	[ [ "fentanyl", "adrenocortical insufficiency" ] ]
According to the Naranjo probability scale, the papular eruption was probably caused by methotrexate.	[ [ "methotrexate", "papular eruption" ] ]
It is believed that this is the first reported case of reversible azathioprine-induced cholestasis associated with histological evidence of bile duct injury.	[ [ "azathioprine", "cholestasis" ] ]
Acute vision loss after intravitreal injection of bevacizumab (avastin) associated with ocular ischemic syndrome.	[ [ "bevacizumab", "Acute vision loss" ], [ "bevacizumab", "ocular ischemic syndrome" ], [ "avastin", "ocular ischemic syndrome" ], [ "avastin", "Acute vision loss" ] ]
Cyclosporine-induced pain syndrome in a child undergoing hematopoietic stem cell transplant.	[ [ "Cyclosporine", "pain syndrome" ] ]
The diagnosis of hypothermia was delayed until it was apparent for several days but resolved with the discontinuation of risperidone and continuation of clozapine.	[ [ "risperidone", "hypothermia" ] ]
Although praziquantel administration may have been effective in killing the parasite in both patients, we are concerned about the production of marked inflammation as a result of treatment.	[ [ "praziquantel", "inflammation" ] ]
We report the occurrence of renal failure due to cholesterol crystal embolization following thrombolytic therapy with intravenous recombinant tissue-type plasminogen activator (t-PA).	[ [ "t-PA", "cholesterol crystal embolization" ], [ "recombinant tissue-type plasminogen activator", "cholesterol crystal embolization" ], [ "recombinant tissue-type plasminogen activator", "renal failure" ], [ "t-PA", "renal failure" ] ]
Deepening of lid sulcus from topical bimatoprost therapy.	[ [ "bimatoprost", "Deepening of lid sulcus" ] ]
Syndrome of inappropriate secretion of ADH (SIADH) following cisplatin administration in a pulmonary adenocarcinoma patient with a malignant pleural effusion.	[ [ "cisplatin", "Syndrome of inappropriate secretion of ADH" ], [ "cisplatin", "SIADH" ] ]
Diagnosis of sclerosing glomerulonephritis occurred in this patient during anastrozole use, suggesting a newly defined side effect of anastrozole.	[ [ "anastrozole", "sclerosing glomerulonephritis" ] ]
Patients with lymphoblastic lymphoma who had treatment with L-asparaginase and steroid are predisposed to the development of cortical venous thrombosis and may have this syndrome in addition to a dural puncture headache.	[ [ "L-asparaginase", "cortical venous thrombosis" ], [ "L-asparaginase", "dural puncture headache" ] ]
Infectious toxicity of dexamethasone during all remission-induction chemotherapy: report of two cases and literature review.	[ [ "dexamethasone", "Infectious toxicity" ] ]
Pathogenesis of methotrexate-induced papular eruption in psoriasis may involve immune mechanisms other than those of methotrexate-induced cutaneous vasculitis in collagen vascular disease.	[ [ "methotrexate", "cutaneous vasculitis" ], [ "methotrexate", "papular eruption" ] ]
Anaphylaxis to intravenous cyclosporine and tolerance to oral cyclosporine: case report and review.	[ [ "cyclosporine", "Anaphylaxis" ] ]
Sagittal sinus thrombosis associated with transient free protein S deficiency after L-asparaginase treatment: case report and review of the literature.	[ [ "L-asparaginase", "Sagittal sinus thrombosis" ], [ "L-asparaginase", "transient free protein S deficiency" ] ]
Two patients developed diabetic coma when taking a combination of a thiazide diuretic and propranolol.	[ [ "thiazide", "diabetic coma" ], [ "propranolol", "diabetic coma" ] ]
The clinical findings and laboratory studies suggested an autoimmune cell-mediated hypersensitivity reaction triggered by phenobarbital.	[ [ "phenobarbital", "autoimmune cell-mediated hypersensitivity" ] ]
The evidence of high plasmatic levels of CBZ and the absence of other aetiologic factors lead the authors to conclude that the overdose of CBZ could have represented the precipitating of the episode of acute pancreatitis.	[ [ "CBZ", "acute pancreatitis" ] ]
How low can you go? Use of very low dosage of gold in patients with mucocutaneous reactions.	[ [ "gold", "mucocutaneous reactions" ] ]
Clozapine is speculated to cause rhabdomyolysis in patients with defective calcium-activated K+ channels.	[ [ "Clozapine", "rhabdomyolysis" ] ]
The first patient developed mild nitritoid symptoms and pain in a band-like distribution, corresponding to T10-T12 dermatomes, shortly after gold sodium thiomalate (GSTM) injection.	[ [ "GSTM", "pain" ], [ "gold sodium thiomalate", "mild nitritoid symptoms" ], [ "gold sodium thiomalate", "T10-T12 dermatomes" ], [ "gold sodium thiomalate", "pain" ], [ "GSTM", "T10-T12 dermatomes" ], [ "GSTM", "mild nitritoid symptoms" ] ]
The authors caution that treatment with alprazolam may be complicated by the induction of mania.	[ [ "alprazolam", "mania" ] ]
We report such a series of patients who had transient asymptomatic bradycardia after being treated with continuous infusion 5-FU.	[ [ "5-FU", "transient asymptomatic bradycardia" ] ]
We describe a case of infection with Mycobacterium abscessus in a 67-year-old woman receiving infliximab as a component of her therapy for RA.	[ [ "infliximab", "Mycobacterium abscessus" ] ]
A 74-year-old man received oral administration of pilsicainide, a pure sodium channel blocker with slow recovery kinetics, to convert paroxysmal atrial fibrillation to sinus rhythm and developed loss of consciousness two days later.	[ [ "pilsicainide", "loss of consciousness" ] ]
CONCLUSION: Significant weight loss is a potential adverse event in patients with rheumatoid arthritis treated with leflunomide.	[ [ "leflunomide", "weight loss" ] ]
We present a pediatric patient with leukemia and a severe, L-asparaginase-induced necrotizing pancreatitis, treated successfully with percutaneous drainage used to flush the infected necrotic parts.	[ [ "L-asparaginase", "necrotizing pancreatitis" ] ]
Central nervous system manifestations of an ibuprofen overdose reversed by naloxone.	[ [ "ibuprofen", "Central nervous system manifestations" ] ]
Sirolimus-associated hepatotoxicity in the kidney graft recipient.	[ [ "Sirolimus", "hepatotoxicity" ] ]
Fixed drug eruption in hands caused by omeprazole.	[ [ "omeprazole", "eruption" ] ]
Imatinib mesylate-related fatal acute hepatic failure in a patient with chronic myeloid leukaemia and chronic hepatitis B infection.	[ [ "Imatinib mesylate", "fatal acute hepatic failure" ] ]
These novel findings may offer specific therapeutic targets in the treatment of BCNU-associated pulmonary fibrosis.	[ [ "BCNU", "pulmonary fibrosis" ] ]
We report a 53-year-old-man who developed rippling muscle disease (RMD) 2 months after starting simvastatin therapy for hypercholesterolemia.	[ [ "simvastatin", "rippling muscle disease" ], [ "simvastatin", "RMD" ] ]
After abstinence from oolong tea his delirium resolved.	[ [ "oolong tea", "delirium" ] ]
Four years after the beginning of IFN therapy, he acutely developed moderate hyperglycemia and severe ketonuria with positive islet cell antibody, and then 28 units/day of insulin injection was started.	[ [ "IFN", "severe ketonuria" ], [ "IFN", "moderate hyperglycemia" ] ]
CONCLUSIONS: This report indicates clindamycin phosphate vaginal cream as the most probable cause of CDIC due to the temporal relationship between the occurrence of diarrhea and clindamycin administration, lack of concomitant medications, and documentation of C. difficile toxin.	[ [ "clindamycin phosphate", "CDIC" ], [ "clindamycin phosphate", "C. difficile toxin" ], [ "clindamycin", "C. difficile toxin" ], [ "clindamycin phosphate", "diarrhea" ], [ "clindamycin", "diarrhea" ], [ "clindamycin", "CDIC" ] ]
The authors describe a case of the catatonia syndrome associated with disulfiram therapy.	[ [ "disulfiram", "catatonia syndrome" ] ]
Graft versus host-like illness in a child with phenobarbital hypersensitivity.	[ [ "phenobarbital", "hypersensitivity" ], [ "phenobarbital", "Graft versus host-like illness" ] ]
Type II heparin-induced thrombocytopenia (HIT) is an immunological disorder characterized by antibodies to heparin-platelet factor 4 complexes and a high risk of thrombotic complications.	[ [ "heparin", "thrombocytopenia" ] ]
The reported cases of in utero exposure to cyclosposphamide shared the following manifestations with our patient: growth deficiency, developmental delay, craniosynostosis, blepharophimosis, flat nasal bridge, abnormal ears, and distal limb defects including hypoplastic thumbs and oligodactyly.	[ [ "cyclosposphamide", "flat nasal bridge" ], [ "cyclosposphamide", "distal limb defects" ], [ "cyclosposphamide", "hypoplastic thumbs" ], [ "cyclosposphamide", "craniosynostosis" ], [ "cyclosposphamide", "developmental delay" ], [ "cyclosposphamide", "blepharophimosis" ], [ "cyclosposphamide", "oligodactyly" ] ]
We report the first biopsy confirmed occurrence of acute interstitial nephritis in a patient receiving treatment with Sunitinib for metastatic renal cell cancer.	[ [ "Sunitinib", "acute interstitial nephritis" ] ]
The occurrence of acute hepatitis is best known for ketoconazole.	[ [ "ketoconazole", "hepatitis" ] ]
CONCLUSIONS: Amphotericin B seems to be the probable cause of the seizures.	[ [ "Amphotericin B", "seizures" ] ]
The main side-effects of Lp-TAE combined with HT were low-grade fever, localized pain, myelo-suppression and liver dysfunction, but these were transient and eventually disappeared.	[ [ "Lp-TAE", "liver dysfunction" ], [ "Lp-TAE", "low-grade fever" ], [ "Lp-TAE", "localized pain" ], [ "Lp-TAE", "myelo-suppression" ] ]
Two reports of spindle coma are noted with alcohol and imipramine.	[ [ "imipramine", "spindle coma" ] ]
BACKGROUND: Hydroxyurea is a cytostatic agent used to treat myeloproliferative disorders and long-term treatment is associated with mucocutaneous adverse events and nail hyperpigmentation.	[ [ "Hydroxyurea", "mucocutaneous adverse events" ], [ "Hydroxyurea", "nail hyperpigmentation" ] ]
Tiagabine overdose causes an unusual array of neurological symptoms, many similar to reported adverse effects during therapeutic use.	[ [ "Tiagabine", "unusual array of neurological symptoms" ] ]
The association of venlafaxine treatment with ischaemic events could be explained by its unique pharmacological and haemodynamic properties.	[ [ "venlafaxine", "ischaemic events" ] ]
We reported 3 patients who developed acute generalized dystonia and akinetic rigid syndrome following an initial therapy with d-penicillamine 125-500 mg daily.	[ [ "d-penicillamine", "acute generalized dystonia" ], [ "d-penicillamine", "akinetic rigid syndrome" ] ]
Tacrolimus (FK506), an immunosuppressant, has been associated with mutism in adults after liver transplant.	[ [ "FK506", "mutism" ], [ "Tacrolimus", "mutism" ] ]
We report a patient of organic bipolar affective disorder who developed hiccups with the atypical antipsychotic aripiprazole.	[ [ "aripiprazole", "hiccups" ] ]
Methemoglobinemia after axillary block with bupivacaine and additional injection of lidocaine in the operative field.	[ [ "bupivacaine", "Methemoglobinemia" ], [ "lidocaine", "Methemoglobinemia" ] ]
Sulfasalazine-induced hypersensitivity syndrome and hemophagocytic syndrome associated with reactivation of Epstein-Barr virus.	[ [ "Sulfasalazine", "hemophagocytic syndrome" ], [ "Sulfasalazine", "hypersensitivity syndrome" ] ]
The occurrence of severe AIHA in CLL patients treated with fludarabine has been reported by several authors.	[ [ "fludarabine", "AIHA" ] ]
Only two case reports of adults with allergic contact dermatitis to this chemical exist in the literature, and we describe three more cases of children with recalcitrant atopic dermatitis found to have potential allergic contact dermatitis to bisabolol- a component of the Aquaphor emollient they were using to treat their atopic dermatitis.	[ [ "bisabolol", "allergic contact dermatitis" ] ]
OBJECTIVE: To describe what is believed, as of November 4, 2003, to be the first case published in the literature of acute interstitial nephritis (AIN) due to pantoprazole.	[ [ "pantoprazole", "acute interstitial nephritis" ] ]
Central pontine myelinolysis manifested by temporary blindness: a possible complication of lithium toxicity.	[ [ "lithium", "temporary blindness" ], [ "lithium", "Central pontine myelinolysis" ] ]
His symptoms of brain stem compression were alleviated and the role of phenytoin in the production of his craniocervical abnormality is discussed.	[ [ "phenytoin", "craniocervical abnormality" ] ]
The authors postulate that two types of combined lithium-neuroleptic toxicity occur: a neuroleptic malignant extrapyramidal syndrome and a lithium toxicity that occurs in combination with phenothiazines, primarily thioridazine.	[ [ "thioridazine", "neuroleptic malignant extrapyramidal syndrome" ], [ "lithium", "lithium toxicity" ], [ "thioridazine", "lithium toxicity" ], [ "lithium", "neuroleptic malignant extrapyramidal syndrome" ] ]
Nevertheless, the coagulopathy seemed to be most closely associated with the administration of the cephalosporin.	[ [ "cephalosporin", "coagulopathy" ] ]
Mannitol-induced ARF responds promptly to hemodialysis with rapid resolution of anuria and recovery of renal failure.	[ [ "Mannitol", "ARF" ] ]
In two patients with mycosis fungoides, a squamous cell carcinoma developed during therapy with psoralens plus long-wave ultraviolet radiation (PUVA).	[ [ "psoralens", "squamous cell carcinoma" ] ]
The reported case represents an unusual association between medication with the proton pump inhibitor lansoprazole and the development of collagenous colitis suggesting the importance of evaluation of drug use in patients with microscopic colitis.	[ [ "lansoprazole", "collagenous colitis" ] ]
Severe hepatitis caused by cyproterone acetate.	[ [ "cyproterone acetate", "Severe hepatitis" ] ]
It was restarted 6 weeks later, and 10 weeks after that, the patient presented with fulminant hepatic failure, which resolved rapidly after cessation of nicotinic acid therapy.	[ [ "nicotinic acid", "fulminant hepatic failure" ] ]
To our knowledge , this is the first reported case of bromide intoxication due to pyridostigmine bromide administration.	[ [ "pyridostigmine bromide", "bromide intoxication" ] ]
Hypotension and sinus arrest with nifedipine in pulmonary hypertension.	[ [ "nifedipine", "Hypotension" ], [ "nifedipine", "sinus arrest" ] ]

Temozolomide-induced desquamative skin rash in a patient with metastatic melanoma.

[ [ "Temozolomide", "desquamative skin rash" ] ]

Flucytosine-associated diarrhea has been previously described in 6%-10% of patients receiving the drug.

[ [ "Flucytosine", "diarrhea" ] ]

Gemcitabine-induced rectus abdominus radiation recall.

[ [ "Gemcitabine", "rectus abdominus radiation recall" ] ]

Vasomotor reactions after gold sodium thiomalate are well recognized.

[ [ "gold sodium thiomalate", "Vasomotor reactions" ] ]

OBJECTIVE: To describe a case of sertraline-induced rhabdomyolysis in an elderly patient with dementia and comorbidities.

[ [ "sertraline", "rhabdomyolysis" ] ]

CASE SUMMARY: Two children with attention deficit disorder treated with methylphenidate as a simple drug developed fixed drug eruption of the scrotum.

[ [ "methylphenidate", "fixed drug eruption of the scrotum" ] ]

The medical examiner's report indicated death caused by fluoxetine toxicity.

[ [ "fluoxetine", "death" ], [ "fluoxetine", "fluoxetine toxicity" ] ]

We report a case of noncardiogenic pulmonary edema developed after therapeutic trial of EO as sclerosing agent for esophageal varix.

[ [ "EO", "noncardiogenic pulmonary edema" ] ]

Methotrexate may rarely provoke serositis, even with low doses and after just a few weeks of therapy.

[ [ "Methotrexate", "serositis" ] ]

We describe in detail the first U.S. case report, of a 4(1/2)-year-old boy who experienced angioedema during treatment with oxcarbazepine.

[ [ "oxcarbazepine", "angioedema" ] ]

Aluminum intoxication, along with other factors, was considered to be the cause of TC development.

[ [ "Aluminum", "Aluminum intoxication" ], [ "Aluminum", "TC" ] ]

Adult respiratory distress syndrome after treatment with pegylated interferon alpha-2a and ribavirin.

[ [ "pegylated interferon alpha-2a", "Adult respiratory distress syndrome" ], [ "ribavirin", "Adult respiratory distress syndrome" ] ]

Treatment of carbimazole-induced agranulocytosis and sepsis with granulocyte colony stimulating factor.

[ [ "carbimazole", "agranulocytosis" ], [ "carbimazole", "sepsis" ] ]

We describe a patient with metastatic prostate cancer who developed nonoliguric renal failure during treatment with suramin.

[ [ "suramin", "nonoliguric renal failure" ] ]

High-dose phosphate treatment leads to hypokalemia in hypophosphatemic osteomalacia.

[ [ "phosphate", "hypokalemia" ] ]

In this case report, we present clinical and laboratory findings of a case with chronic hepatitis B that developed acute dystonia soon after the first dose of pegylated interferon alpha.

[ [ "pegylated interferon alpha", "acute dystonia" ] ]

The use of pamidronate for hypercalcemia secondary to acute vitamin D intoxication.

[ [ "vitamin D", "vitamin D intoxication" ] ]

CONCLUSIONS: Itraconazole-induced liver injury presents with a cholestatic pattern of injury with damage to the interlobular bile ducts, possibly leading to ductopenia.

[ [ "Itraconazole", "damage to the interlobular bile ducts" ], [ "Itraconazole", "liver injury" ], [ "Itraconazole", "ductopenia" ], [ "Itraconazole", "cholestatic pattern of injury" ] ]

The frequency and relationship of granulocytopenia caused by sustained-release procainamide in patients with tachyarrhythmias are briefly discussed, and prior reported cases are reviewed.

[ [ "procainamide", "granulocytopenia" ] ]

Toxic hepatitis due to combination therapy with methotrexate and etretinate in psoriasis.

[ [ "methotrexate", "Toxic hepatitis" ], [ "etretinate", "Toxic hepatitis" ] ]

An obese patient, not diabetic, treated with metformin for some weeks, was referred to us with severe inferior digestive hemorrhage, diagnosed with Meckel's diverticulum.

[ [ "metformin", "severe inferior digestive hemorrhage" ] ]

Temsirolimus-induced glomerulopathy.

[ [ "Temsirolimus", "glomerulopathy" ] ]

Escape atrial complexes, which occurred following junctional premature complexes, failed to initiate tachycardia in the control state but tachycardia was always reinitiated by an identical escape sequence after procainamide.

[ [ "procainamide", "tachycardia" ] ]

No explanation for this delay was found, other than the possibility that magnesium sulfate treatment impeded lactogenesis.

[ [ "magnesium sulfate", "impeded lactogenesis" ] ]

Lithium neurotoxicity should be considered in Creutzfeldt-Jakob disease differential diagnosis, serial electroencephalograms being the most valuable.

[ [ "Lithium", "Lithium neurotoxicity" ], [ "Lithium", "Creutzfeldt-Jakob disease" ] ]

A case of acute cardiomyopathy and pericarditis associated with methylphenidate.

[ [ "methylphenidate", "pericarditis" ], [ "methylphenidate", "acute cardiomyopathy" ] ]

Oral intake and acarbose were withheld and the ileus spontaneously resolved after 2 days.

[ [ "acarbose", "ileus" ] ]

Anaphylactic reaction to oral prednisone: a case report and review of the literature.

[ [ "prednisone", "Anaphylactic reaction" ] ]

Biomicroscopy revealed amiodarone corneal deposits.

[ [ "amiodarone", "corneal deposits" ] ]

OBJECTIVE: To describe a patient with asymptomatic bronchial asthma and hypertension who developed an acute asthma attack after receiving sustained-release verapamil.

[ [ "verapamil", "acute asthma" ] ]

While on a maximal dose of phenylephrine she developed prominent positive U waves, which disappeared with the cessation of the drug.

[ [ "phenylephrine", "positive U waves" ] ]

Thalidomide neuropathy in childhood.

[ [ "Thalidomide", "neuropathy" ] ]

We report a case of a 64-year-old man with secondary adrenocortical insufficiency who has been on a chronic transdermal fentanyl treatment because of sciatic pain syndrome.

[ [ "fentanyl", "adrenocortical insufficiency" ] ]

According to the Naranjo probability scale, the papular eruption was probably caused by methotrexate.

[ [ "methotrexate", "papular eruption" ] ]

It is believed that this is the first reported case of reversible azathioprine-induced cholestasis associated with histological evidence of bile duct injury.

[ [ "azathioprine", "cholestasis" ] ]

Acute vision loss after intravitreal injection of bevacizumab (avastin) associated with ocular ischemic syndrome.

[ [ "bevacizumab", "Acute vision loss" ], [ "bevacizumab", "ocular ischemic syndrome" ], [ "avastin", "ocular ischemic syndrome" ], [ "avastin", "Acute vision loss" ] ]

Cyclosporine-induced pain syndrome in a child undergoing hematopoietic stem cell transplant.

[ [ "Cyclosporine", "pain syndrome" ] ]

The diagnosis of hypothermia was delayed until it was apparent for several days but resolved with the discontinuation of risperidone and continuation of clozapine.

[ [ "risperidone", "hypothermia" ] ]

Although praziquantel administration may have been effective in killing the parasite in both patients, we are concerned about the production of marked inflammation as a result of treatment.

[ [ "praziquantel", "inflammation" ] ]

We report the occurrence of renal failure due to cholesterol crystal embolization following thrombolytic therapy with intravenous recombinant tissue-type plasminogen activator (t-PA).

[ [ "t-PA", "cholesterol crystal embolization" ], [ "recombinant tissue-type plasminogen activator", "cholesterol crystal embolization" ], [ "recombinant tissue-type plasminogen activator", "renal failure" ], [ "t-PA", "renal failure" ] ]

Deepening of lid sulcus from topical bimatoprost therapy.

[ [ "bimatoprost", "Deepening of lid sulcus" ] ]

Syndrome of inappropriate secretion of ADH (SIADH) following cisplatin administration in a pulmonary adenocarcinoma patient with a malignant pleural effusion.

[ [ "cisplatin", "Syndrome of inappropriate secretion of ADH" ], [ "cisplatin", "SIADH" ] ]

Diagnosis of sclerosing glomerulonephritis occurred in this patient during anastrozole use, suggesting a newly defined side effect of anastrozole.

[ [ "anastrozole", "sclerosing glomerulonephritis" ] ]

Patients with lymphoblastic lymphoma who had treatment with L-asparaginase and steroid are predisposed to the development of cortical venous thrombosis and may have this syndrome in addition to a dural puncture headache.

[ [ "L-asparaginase", "cortical venous thrombosis" ], [ "L-asparaginase", "dural puncture headache" ] ]

Infectious toxicity of dexamethasone during all remission-induction chemotherapy: report of two cases and literature review.

[ [ "dexamethasone", "Infectious toxicity" ] ]

Pathogenesis of methotrexate-induced papular eruption in psoriasis may involve immune mechanisms other than those of methotrexate-induced cutaneous vasculitis in collagen vascular disease.

[ [ "methotrexate", "cutaneous vasculitis" ], [ "methotrexate", "papular eruption" ] ]

Anaphylaxis to intravenous cyclosporine and tolerance to oral cyclosporine: case report and review.

[ [ "cyclosporine", "Anaphylaxis" ] ]

Sagittal sinus thrombosis associated with transient free protein S deficiency after L-asparaginase treatment: case report and review of the literature.

[ [ "L-asparaginase", "Sagittal sinus thrombosis" ], [ "L-asparaginase", "transient free protein S deficiency" ] ]

Two patients developed diabetic coma when taking a combination of a thiazide diuretic and propranolol.

[ [ "thiazide", "diabetic coma" ], [ "propranolol", "diabetic coma" ] ]

The clinical findings and laboratory studies suggested an autoimmune cell-mediated hypersensitivity reaction triggered by phenobarbital.

[ [ "phenobarbital", "autoimmune cell-mediated hypersensitivity" ] ]

The evidence of high plasmatic levels of CBZ and the absence of other aetiologic factors lead the authors to conclude that the overdose of CBZ could have represented the precipitating of the episode of acute pancreatitis.

[ [ "CBZ", "acute pancreatitis" ] ]

How low can you go? Use of very low dosage of gold in patients with mucocutaneous reactions.

[ [ "gold", "mucocutaneous reactions" ] ]

Clozapine is speculated to cause rhabdomyolysis in patients with defective calcium-activated K+ channels.

[ [ "Clozapine", "rhabdomyolysis" ] ]

The first patient developed mild nitritoid symptoms and pain in a band-like distribution, corresponding to T10-T12 dermatomes, shortly after gold sodium thiomalate (GSTM) injection.

[ [ "GSTM", "pain" ], [ "gold sodium thiomalate", "mild nitritoid symptoms" ], [ "gold sodium thiomalate", "T10-T12 dermatomes" ], [ "gold sodium thiomalate", "pain" ], [ "GSTM", "T10-T12 dermatomes" ], [ "GSTM", "mild nitritoid symptoms" ] ]

The authors caution that treatment with alprazolam may be complicated by the induction of mania.

[ [ "alprazolam", "mania" ] ]

We report such a series of patients who had transient asymptomatic bradycardia after being treated with continuous infusion 5-FU.

[ [ "5-FU", "transient asymptomatic bradycardia" ] ]

We describe a case of infection with Mycobacterium abscessus in a 67-year-old woman receiving infliximab as a component of her therapy for RA.

[ [ "infliximab", "Mycobacterium abscessus" ] ]

A 74-year-old man received oral administration of pilsicainide, a pure sodium channel blocker with slow recovery kinetics, to convert paroxysmal atrial fibrillation to sinus rhythm and developed loss of consciousness two days later.

[ [ "pilsicainide", "loss of consciousness" ] ]

CONCLUSION: Significant weight loss is a potential adverse event in patients with rheumatoid arthritis treated with leflunomide.

[ [ "leflunomide", "weight loss" ] ]

We present a pediatric patient with leukemia and a severe, L-asparaginase-induced necrotizing pancreatitis, treated successfully with percutaneous drainage used to flush the infected necrotic parts.

[ [ "L-asparaginase", "necrotizing pancreatitis" ] ]

Central nervous system manifestations of an ibuprofen overdose reversed by naloxone.

[ [ "ibuprofen", "Central nervous system manifestations" ] ]

Sirolimus-associated hepatotoxicity in the kidney graft recipient.

[ [ "Sirolimus", "hepatotoxicity" ] ]

Fixed drug eruption in hands caused by omeprazole.

[ [ "omeprazole", "eruption" ] ]

Imatinib mesylate-related fatal acute hepatic failure in a patient with chronic myeloid leukaemia and chronic hepatitis B infection.

[ [ "Imatinib mesylate", "fatal acute hepatic failure" ] ]

These novel findings may offer specific therapeutic targets in the treatment of BCNU-associated pulmonary fibrosis.

[ [ "BCNU", "pulmonary fibrosis" ] ]

We report a 53-year-old-man who developed rippling muscle disease (RMD) 2 months after starting simvastatin therapy for hypercholesterolemia.

[ [ "simvastatin", "rippling muscle disease" ], [ "simvastatin", "RMD" ] ]

After abstinence from oolong tea his delirium resolved.

[ [ "oolong tea", "delirium" ] ]

Four years after the beginning of IFN therapy, he acutely developed moderate hyperglycemia and severe ketonuria with positive islet cell antibody, and then 28 units/day of insulin injection was started.

[ [ "IFN", "severe ketonuria" ], [ "IFN", "moderate hyperglycemia" ] ]

CONCLUSIONS: This report indicates clindamycin phosphate vaginal cream as the most probable cause of CDIC due to the temporal relationship between the occurrence of diarrhea and clindamycin administration, lack of concomitant medications, and documentation of C. difficile toxin.

[ [ "clindamycin phosphate", "CDIC" ], [ "clindamycin phosphate", "C. difficile toxin" ], [ "clindamycin", "C. difficile toxin" ], [ "clindamycin phosphate", "diarrhea" ], [ "clindamycin", "diarrhea" ], [ "clindamycin", "CDIC" ] ]

The authors describe a case of the catatonia syndrome associated with disulfiram therapy.

[ [ "disulfiram", "catatonia syndrome" ] ]

Graft versus host-like illness in a child with phenobarbital hypersensitivity.

[ [ "phenobarbital", "hypersensitivity" ], [ "phenobarbital", "Graft versus host-like illness" ] ]

Type II heparin-induced thrombocytopenia (HIT) is an immunological disorder characterized by antibodies to heparin-platelet factor 4 complexes and a high risk of thrombotic complications.

[ [ "heparin", "thrombocytopenia" ] ]

The reported cases of in utero exposure to cyclosposphamide shared the following manifestations with our patient: growth deficiency, developmental delay, craniosynostosis, blepharophimosis, flat nasal bridge, abnormal ears, and distal limb defects including hypoplastic thumbs and oligodactyly.

[ [ "cyclosposphamide", "flat nasal bridge" ], [ "cyclosposphamide", "distal limb defects" ], [ "cyclosposphamide", "hypoplastic thumbs" ], [ "cyclosposphamide", "craniosynostosis" ], [ "cyclosposphamide", "developmental delay" ], [ "cyclosposphamide", "blepharophimosis" ], [ "cyclosposphamide", "oligodactyly" ] ]

We report the first biopsy confirmed occurrence of acute interstitial nephritis in a patient receiving treatment with Sunitinib for metastatic renal cell cancer.

[ [ "Sunitinib", "acute interstitial nephritis" ] ]

The occurrence of acute hepatitis is best known for ketoconazole.

[ [ "ketoconazole", "hepatitis" ] ]

CONCLUSIONS: Amphotericin B seems to be the probable cause of the seizures.

[ [ "Amphotericin B", "seizures" ] ]

The main side-effects of Lp-TAE combined with HT were low-grade fever, localized pain, myelo-suppression and liver dysfunction, but these were transient and eventually disappeared.

[ [ "Lp-TAE", "liver dysfunction" ], [ "Lp-TAE", "low-grade fever" ], [ "Lp-TAE", "localized pain" ], [ "Lp-TAE", "myelo-suppression" ] ]

Two reports of spindle coma are noted with alcohol and imipramine.

[ [ "imipramine", "spindle coma" ] ]

BACKGROUND: Hydroxyurea is a cytostatic agent used to treat myeloproliferative disorders and long-term treatment is associated with mucocutaneous adverse events and nail hyperpigmentation.

[ [ "Hydroxyurea", "mucocutaneous adverse events" ], [ "Hydroxyurea", "nail hyperpigmentation" ] ]

Tiagabine overdose causes an unusual array of neurological symptoms, many similar to reported adverse effects during therapeutic use.

[ [ "Tiagabine", "unusual array of neurological symptoms" ] ]

The association of venlafaxine treatment with ischaemic events could be explained by its unique pharmacological and haemodynamic properties.

[ [ "venlafaxine", "ischaemic events" ] ]

We reported 3 patients who developed acute generalized dystonia and akinetic rigid syndrome following an initial therapy with d-penicillamine 125-500 mg daily.

[ [ "d-penicillamine", "acute generalized dystonia" ], [ "d-penicillamine", "akinetic rigid syndrome" ] ]

Tacrolimus (FK506), an immunosuppressant, has been associated with mutism in adults after liver transplant.

[ [ "FK506", "mutism" ], [ "Tacrolimus", "mutism" ] ]

We report a patient of organic bipolar affective disorder who developed hiccups with the atypical antipsychotic aripiprazole.

[ [ "aripiprazole", "hiccups" ] ]

Methemoglobinemia after axillary block with bupivacaine and additional injection of lidocaine in the operative field.

[ [ "bupivacaine", "Methemoglobinemia" ], [ "lidocaine", "Methemoglobinemia" ] ]

Sulfasalazine-induced hypersensitivity syndrome and hemophagocytic syndrome associated with reactivation of Epstein-Barr virus.

[ [ "Sulfasalazine", "hemophagocytic syndrome" ], [ "Sulfasalazine", "hypersensitivity syndrome" ] ]

The occurrence of severe AIHA in CLL patients treated with fludarabine has been reported by several authors.

[ [ "fludarabine", "AIHA" ] ]

Only two case reports of adults with allergic contact dermatitis to this chemical exist in the literature, and we describe three more cases of children with recalcitrant atopic dermatitis found to have potential allergic contact dermatitis to bisabolol- a component of the Aquaphor emollient they were using to treat their atopic dermatitis.

[ [ "bisabolol", "allergic contact dermatitis" ] ]

OBJECTIVE: To describe what is believed, as of November 4, 2003, to be the first case published in the literature of acute interstitial nephritis (AIN) due to pantoprazole.

[ [ "pantoprazole", "acute interstitial nephritis" ] ]

Central pontine myelinolysis manifested by temporary blindness: a possible complication of lithium toxicity.

[ [ "lithium", "temporary blindness" ], [ "lithium", "Central pontine myelinolysis" ] ]

His symptoms of brain stem compression were alleviated and the role of phenytoin in the production of his craniocervical abnormality is discussed.

[ [ "phenytoin", "craniocervical abnormality" ] ]

The authors postulate that two types of combined lithium-neuroleptic toxicity occur: a neuroleptic malignant extrapyramidal syndrome and a lithium toxicity that occurs in combination with phenothiazines, primarily thioridazine.

[ [ "thioridazine", "neuroleptic malignant extrapyramidal syndrome" ], [ "lithium", "lithium toxicity" ], [ "thioridazine", "lithium toxicity" ], [ "lithium", "neuroleptic malignant extrapyramidal syndrome" ] ]

Nevertheless, the coagulopathy seemed to be most closely associated with the administration of the cephalosporin.

[ [ "cephalosporin", "coagulopathy" ] ]

Mannitol-induced ARF responds promptly to hemodialysis with rapid resolution of anuria and recovery of renal failure.

[ [ "Mannitol", "ARF" ] ]

In two patients with mycosis fungoides, a squamous cell carcinoma developed during therapy with psoralens plus long-wave ultraviolet radiation (PUVA).

[ [ "psoralens", "squamous cell carcinoma" ] ]

The reported case represents an unusual association between medication with the proton pump inhibitor lansoprazole and the development of collagenous colitis suggesting the importance of evaluation of drug use in patients with microscopic colitis.

[ [ "lansoprazole", "collagenous colitis" ] ]

Severe hepatitis caused by cyproterone acetate.

[ [ "cyproterone acetate", "Severe hepatitis" ] ]

It was restarted 6 weeks later, and 10 weeks after that, the patient presented with fulminant hepatic failure, which resolved rapidly after cessation of nicotinic acid therapy.

[ [ "nicotinic acid", "fulminant hepatic failure" ] ]

To our knowledge , this is the first reported case of bromide intoxication due to pyridostigmine bromide administration.

[ [ "pyridostigmine bromide", "bromide intoxication" ] ]

Hypotension and sinus arrest with nifedipine in pulmonary hypertension.

[ [ "nifedipine", "Hypotension" ], [ "nifedipine", "sinus arrest" ] ]