harpreetmann/entity_extraction_ade · Datasets at Hugging Face

text stringlengths 22 455	pairs listlengths 1 24
Anaphylaxis after the injection of chymopapain occurs in about 1% of such cases.	[ [ "chymopapain", "Anaphylaxis" ] ]
Excluding other causes, Pentasa-associated pancytopenia was considered.	[ [ "Pentasa", "pancytopenia" ] ]
These findings suggest that clozapine-induced seizures can be successfully treated, that gradual dose titration can reduce the likelihood of further episodes of seizures and that concomitant use of a suitable mood stabilizer/anti-epileptic medication can improve the outcome of treatment-resistant schizophrenia.	[ [ "clozapine", "seizures" ] ]
While most physicians are aware of heparin-induced thrombocytopenia and skin necrosis, the association of heparin and hyperkalemia is less well recognized.	[ [ "heparin", "hyperkalemia" ], [ "heparin", "skin necrosis" ], [ "heparin", "thrombocytopenia" ] ]
The induced hyperglycaemia could not be controlled sufficiently, despite a high dose of insulin (> 110 units/day), suggesting the existence of insulin insensitivity and hyperinsulinaemia.	[ [ "insulin", "hyperinsulinaemia" ], [ "insulin", "insulin insensitivity" ] ]
Five days after the fourth dose of vincristine, she presented with bilateral ptosis.	[ [ "vincristine", "bilateral ptosis" ] ]
The typical fluoxetine-induced symptoms of restlessness, constant pacing, purposeless movements of the feet and legs, and marked anxiety were indistinguishable from those of neuroleptic-induced akathisia.	[ [ "fluoxetine", "purposeless movements of the feet and legs" ], [ "fluoxetine", "restlessness" ], [ "fluoxetine", "constant pacing" ], [ "fluoxetine", "marked anxiety" ] ]
Levofloxacin-induced delirium with psychotic features.	[ [ "Levofloxacin", "delirium with psychotic features" ] ]
We are concerned that the macular lesion was a retinal toxic effect of gentamicin because of the recent description of similar lesions occurring after the inadvertent intraocular injection of massive doses of this drug.	[ [ "gentamicin", "macular lesion" ] ]
After the addition of citalopram, a desmethylclomipramine plasma level increase and an 8-hydroacy-desmethylclomipramine plasma level decrease were observed.	[ [ "citalopram", "desmethylclomipramine plasma level increase" ], [ "citalopram", "8-hydroacy-desmethylclomipramine plasma level decrease" ] ]
Eosinophilia caused by clozapine was observed in challenge, preceded by a faster neutrophil production and consecutive decrease (z = 2.27, p = 0.01).	[ [ "clozapine", "Eosinophilia" ] ]
This supports the well-reported potential of bleomycin to trigger acral vascular toxicity.	[ [ "bleomycin", "acral vascular toxicity" ] ]
An infant girl with choanal atresia, athelia, minor anomalies, and mild to moderate mental retardation was born to a woman treated for hyperthyroidism throughout pregnancy with methimazole and propranolol.	[ [ "propranolol", "athelia" ], [ "methimazole", "mental retardation" ], [ "propranolol", "choanal atresia" ], [ "methimazole", "choanal atresia" ], [ "methimazole", "athelia" ], [ "propranolol", "mental retardation" ] ]
CONCLUSIONS: Although mirtazapine offers clinicians a combination of strong efficacy and good safety, we suggest bearing SS in mind when prescribing this drug, especially in frail, elderly patients with underlying chronic conditions.	[ [ "mirtazapine", "SS" ] ]
Several such HBV reactivations were reported after combined rituximab and multiagent chemotherapy for B-cell lymphomas.	[ [ "rituximab", "HBV reactivations" ] ]
We report the first case of a human immunodeficiency virus type 1 (HIV-1)-infected individual receiving combination antiretroviral therapy, which included ritonavir, who developed Cushing syndrome with profound complications after epidural triamcinolone injections.	[ [ "triamcinolone", "Cushing syndrome" ] ]
METHOD: Case analysis of a poly-drug overdose (venlafaxine, topiramate, divalproex sodium, risperidone, and carbamazepine) presenting with mixed SS/NMS features and whose clinical management suggests a practical algorithm for treatment of undifferentiated SS/NMS in critical care settings.	[ [ "risperidone", "SS" ], [ "divalproex sodium", "SS" ], [ "venlafaxine", "SS" ], [ "carbamazepine", "NMS" ], [ "topiramate", "SS" ], [ "risperidone", "NMS" ], [ "venlafaxine", "NMS" ], [ "divalproex sodium", "NMS" ], [ "topiramate", "NMS" ], [ "carbamazepine", "SS" ] ]
Transient phenytoin induced IgA deficiency and permanent IgE increase.	[ [ "phenytoin", "IgA deficiency" ], [ "phenytoin", "IgE increase" ] ]
Cutaneous eruptions occur in 3% of individuals administered carbamazepine.	[ [ "carbamazepine", "Cutaneous eruptions" ] ]
This sulfonamide like nephropathy should be differentiated from acetazolamide-related calcium phosphate nephrolithiasis.	[ [ "acetazolamide", "calcium phosphate nephrolithiasis" ] ]
The relation between tacrolimus treatment and staining was suggested by the appearance of pigmentation during topical tacrolimus treatment and its clinical disappearance when treatment was stopped.	[ [ "tacrolimus", "pigmentation" ] ]
We report an unusual case of simultaneous transitional cell carcinoma of the renal pelvis and distal ureter without transitional cell carcinoma of the bladder occurring after chronic cyclophosphamide therapy for nonHodgkin's lymphoma.	[ [ "cyclophosphamide", "transitional cell carcinoma of the renal pelvis" ], [ "cyclophosphamide", "distal ureter without transitional cell carcinoma of the bladder" ] ]
We report a case of secondary glaucoma caused by epithelial downgrowth in which filtration surgery was performed with adjunctive use of subconjunctival 5-fluorouracil.	[ [ "5-fluorouracil", "glaucoma" ] ]
Seizures associated with fluoxetine therapy are uncommon.	[ [ "fluoxetine", "Seizures" ] ]
However, each infant demonstrated hemodynamic decompensation shortly after verapamil administration and required cardiopulmonary resuscitation.	[ [ "verapamil", "hemodynamic decompensation" ] ]
We present a case of the syndrome of inappropriate antidiuretic hormone (SIADH) secondary to cisplatin therapy in a patient with advanced-stage large cell neuroendocrine carcinoma of the cervix.	[ [ "cisplatin", "syndrome of inappropriate antidiuretic hormone" ], [ "cisplatin", "SIADH" ] ]
The authors report five additional cases of capecitabine-induced multifocal leukoencephalopathy.	[ [ "capecitabine", "multifocal leukoencephalopathy" ] ]
A rare case of advanced ovarian carcinoma who developed difficulty walking 25 days after treatment with weekly paclitaxel.	[ [ "paclitaxel", "difficulty walking" ] ]
Esophageal spasm following propranolol overdose relieved by glucagon.	[ [ "propranolol", "Esophageal spasm" ] ]
We report three patients, all of whom had preexisting diabetic dyslipidemia, who showed a profound reduction in plasma HDL cholesterol and apolipoprotein AI levels soon after the initiation of rosiglitazone therapy.	[ [ "rosiglitazone", "reduction in plasma HDL cholesterol and apolipoprotein AI levels" ] ]
We hypothesize that caffeine toxicity injured the muscle cells, which were fragile due to the potassium depletion induced by the coexisting hyponatremia, to result in unusually severe rhabdomyolysis.	[ [ "caffeine", "rhabdomyolysis" ], [ "caffeine", "potassium depletion" ], [ "caffeine", "coexisting hyponatremia" ], [ "caffeine", "caffeine toxicity" ], [ "caffeine", "injured the muscle cells" ] ]
CONCLUSIONS: The observation that neurotoxicity developed with a delay of 24 to 48 hours after acyclovir peak serum concentrations could explain the wide range of acyclovir levels reported in similar cases.	[ [ "acyclovir", "neurotoxicity" ] ]
A 67-year-old patient, with primary polymyositis and without previous evidence of liver disease, developed clinical and biochemical features of severe cholestasis 3 months after initiation of azathioprine therapy.	[ [ "azathioprine", "severe cholestasis" ] ]
CONCLUSIONS: The piloerection observed after the replacement of fluvoxamine with milnacipran in this patient appears to have been due to an increase in the alpha(1)-adrenoceptor occupancy by endogenous norepinephrine induced by milnacipran.	[ [ "fluvoxamine", "piloerection" ], [ "milnacipran", "piloerection" ] ]
We report on a 14-year-old boy with severe haemophilia A who developed a portal vein thrombosis during continuous infusion of F VIII.	[ [ "F VIII", "portal vein thrombosis" ] ]
A 35-year-old man with seropositive rheumatoid arthritis developed selective IgA deficiency during treatment with fenclofenac.	[ [ "fenclofenac", "IgA deficiency" ] ]
A 74-year-old hypercholestrerolaemic woman taking cerivastatin (0.15 mg/day) for 22 days complained of general muscle weakness and muscle pain.	[ [ "cerivastatin", "muscle weakness" ], [ "cerivastatin", "muscle pain" ] ]
We describe two dark-skinned patients who developed hyperpigmented skin and tongue lesions during combination therapy with IFN and ribavirin.	[ [ "IFN", "tongue lesions" ], [ "ribavirin", "hyperpigmented skin" ], [ "IFN", "hyperpigmented skin" ], [ "ribavirin", "tongue lesions" ] ]
The second patient experienced mild nitritoid symptoms following several GSTM injections prior experiencing a cerebrovascular accident within several hours of her next injection.	[ [ "GSTM", "mild nitritoid symptoms" ] ]
In a phase II study of hycanthone in patients with breast cancer we have recently observed severe hepatotoxicity, even at lower doses, which resulted in two drug-related deaths.	[ [ "hycanthone", "severe hepatotoxicity" ] ]
A 40-year-old man with advanced HIV infection and Mycobacterium avium complex infection experienced rapid cognitive decline after commencement of ethambutol, and symptoms fully resolved with cessation.	[ [ "ethambutol", "rapid cognitive decline" ] ]
An apparent link is described between the use of MMF with prednisone to treat pemphigus vulgaris and the development of red blood cell anemia.	[ [ "prednisone", "red blood cell anemia" ], [ "MMF", "red blood cell anemia" ] ]
We report a case of a patient with pulmonary hypertension and undifferentiated connective tissue disease who, after 2 months of treatment with epoprostenol, presented with rapidly progressive erythema, scaling, nausea and vomiting, and fever.	[ [ "epoprostenol", "fever" ], [ "epoprostenol", "scaling" ], [ "epoprostenol", "vomiting" ], [ "epoprostenol", "rapidly progressive erythema" ], [ "epoprostenol", "nausea" ] ]
Hyperglycemia and diabetic coma: possible relationship to diuretic-propranolol therapy.	[ [ "propranolol", "Hyperglycemia" ], [ "propranolol", "diabetic coma" ] ]
Four weeks earlier she had developed hepatopathy during a regimen of carbamazepine, lynestrenol and sodium valproate.	[ [ "carbamazepine", "hepatopathy" ], [ "lynestrenol", "hepatopathy" ], [ "sodium valproate", "hepatopathy" ] ]
Recovery of the tubular dysfunction took 15 days following cessation of the offending drug, Amikacin.	[ [ "Amikacin", "tubular dysfunction" ] ]
We conclude that myocardial infarction may develop in patients treated with high-dose glucocorticoids for Graves' ophthalmopathy, and increased blood pressure may herald this complication.	[ [ "glucocorticoids", "myocardial infarction" ] ]
Hemorrhagic cystitis is a significant toxic effect of cyclophosphamide therapy.	[ [ "cyclophosphamide", "Hemorrhagic cystitis" ] ]
In some cases this seems to happen because spironolactone causes diarrhoea.	[ [ "spironolactone", "diarrhoea" ] ]
We report two patients with acne vulgaris with a fourth type of minocycline-induced cutaneous pigmentation.	[ [ "minocycline", "cutaneous pigmentation" ] ]
A case of severe acute hepatitis caused by cyproterone acetate in a 71 year old man with prostatic carcinoma is reported with a review of the literature on hepatic reactions to this drug.	[ [ "cyproterone acetate", "severe acute hepatitis" ] ]
CASE PRESENTATION: We report a patient with CF who developed recurrent eosinophilia and severe persistent bronchospasm following repeated administration of preservative-free tobramycin by inhalation, beginning at 16 months of age.	[ [ "tobramycin", "severe persistent bronchospasm" ], [ "tobramycin", "recurrent eosinophilia" ] ]
Peculiar nail-changes in a 70-year-old woman with rheumatoid arthritis occurring after approximately 1 year of penicillamine treatment are described.	[ [ "penicillamine", "nail-changes" ] ]
A severe form of exophthalmos resulting from lithium therapy has not been described in the literature.	[ [ "lithium", "exophthalmos" ] ]
Disseminated eruptive giant mollusca contagiosa in an adult psoriasis patient during efalizumab therapy.	[ [ "efalizumab", "Disseminated eruptive giant mollusca contagiosa" ] ]
Myoclonus and seizures in a patient with parkinsonism: induction by levodopa and its confirmation on SEPs.	[ [ "levodopa", "Myoclonus" ], [ "levodopa", "seizures" ] ]
Cutaneous seeding after ultrasound-guided percutaneous ethanol injection for treatment of hepatocellular carcinoma.	[ [ "ethanol injection", "Cutaneous seeding" ] ]
Neurologic symptoms resolved after stopping CAP for 4 weeks in Patient A, with no recurrence after reinitiating CAP alone at 2000 mg/m2.	[ [ "CAP", "Neurologic symptoms" ] ]
After therapy for diabetic coma with insulin (containing the preservative cresol) and electrolyte solutions was started, the patient complained of increasing myalgia, developed a high fever and respiratory and metabolic acidosis and lost consciousness.	[ [ "insulin", "lost consciousness" ], [ "cresol", "lost consciousness" ], [ "insulin", "respiratory and metabolic acidosis" ], [ "cresol", "increasing myalgia" ], [ "cresol", "respiratory and metabolic acidosis" ], [ "cresol", "high fever" ], [ "insulin", "increasing myalgia" ], [ "insulin", "high fever" ] ]
Only a few reports of overt jaundice are associated with streptokinase.	[ [ "streptokinase", "jaundice" ] ]
Heat stroke-like episode in a child caused by zonisamide.	[ [ "zonisamide", "Heat stroke-like episode" ] ]
The chemotherapeutics, including vincristine, actinomycin D, and epirubicin in case 1 and vincristine and actinomycin D in case 2, were given before the hepatotoxicity developed.	[ [ "actinomycin D", "hepatotoxicity" ], [ "vincristine", "hepatotoxicity" ], [ "epirubicin", "hepatotoxicity" ] ]
In this paper, we report a patient with primary anti-phospholipid syndrome treated by corticosteroid, who developed disseminated nocardiosis.	[ [ "corticosteroid", "disseminated nocardiosis" ] ]
It was concluded that ANCA is closely related to the pathogenesis of crescentic glomerulonephritis and that treatment with PTU appeared to induce ANCA.	[ [ "PTU", "ANCA" ] ]
Here we present the case of a generalized lichen nitidus with involvement of the palms in a patient with hepatitis C after systemic treatment with interferon alpha and ribavirin.	[ [ "interferon alpha", "generalized lichen nitidus" ], [ "ribavirin", "generalized lichen nitidus" ] ]
Insulin-induced lipoatrophy in type I diabetes.	[ [ "Insulin", "lipoatrophy" ] ]
To date, this is the first reported case of what appears to be isolated thrombocytopenia associated with lansoprazole.	[ [ "lansoprazole", "thrombocytopenia" ] ]
The case histories are presented of two patients who developed lung disease associated with the use of nitrofurantoin with histological features of bronchiolitis obliterans organising pneumonia (BOOP), a rare but recognised form of drug induced injury.	[ [ "nitrofurantoin", "lung disease" ], [ "nitrofurantoin", "BOOP" ], [ "nitrofurantoin", "bronchiolitis obliterans organising pneumonia" ] ]
Acute respiratory distress syndrome after rituximab infusion.	[ [ "rituximab", "Acute respiratory distress syndrome" ] ]
We report an HIV-infected woman who developed mild leukopenia as the first sign of a nevirapine-related adverse event, which was followed by skin and hepatic toxicity associated with a more severe leukopenia.	[ [ "nevirapine", "skin and hepatic toxicity" ], [ "nevirapine", "leukopenia" ] ]
Apparent cyclophosphamide (cytoxan) embryopathy: a distinct phenotype?	[ [ "cyclophosphamide", "embryopathy" ] ]
Drug-induced fever should be considered in patients who have unexplained high temperatures during diltiazem therapy.	[ [ "diltiazem", "fever" ] ]
A unique case of a transient, nonpigmenting fixed drug eruption caused by the radiopaque contrast medium iothalamate is reported.	[ [ "iothalamate", "fixed drug eruption" ] ]
She received an accidental 450-mg bolus injection of morphine intrathecally and developed hypertension, status epilepticus, intracerebral hemorrhage, and respiratory failure.	[ [ "morphine", "intracerebral hemorrhage" ], [ "morphine", "status epilepticus" ], [ "morphine", "respiratory failure" ], [ "morphine", "hypertension" ] ]
CD20-negative T-cell-rich B-cell lymphoma as a progression of a nodular lymphocyte-predominant Hodgkin's lymphoma treated with rituximab: a molecular analysis using laser capture microdissection.	[ [ "rituximab", "CD20-negative T-cell-rich B-cell lymphoma" ] ]
Five patients are described in whom only gentamicin sulfate appeared responsible for acute renal failure.	[ [ "gentamicin sulfate", "acute renal failure" ] ]
Similar to reports in patients receiving gefitinib, those with pathologic findings of UIP on resected lung specimens or known pulmonary fibrosis may be at particular risk for erlotinib pulmonary toxicity.	[ [ "erlotinib", "pulmonary fibrosis" ], [ "erlotinib", "pulmonary toxicity" ] ]
Pemphigus vulgaris precipitated by glibenclamide therapy.	[ [ "glibenclamide", "Pemphigus vulgaris" ] ]
Trichiasis associated with prostaglandin analog use.	[ [ "prostaglandin", "Trichiasis" ] ]
OBSERVATIONS: We observed aggravation and spreading of a psoriatic plaque when treated topically with the toll-like receptor (TLR) 7 agonist imiquimod.	[ [ "imiquimod", "aggravation and spreading of a psoriatic plaque" ] ]
A case of congestive heart failure in a child with Wilms' tumor treated Adriamycin is presented and discussed.	[ [ "Adriamycin", "congestive heart failure" ] ]
Methotrexate-induced leukoencephalopathy is treatable with high-dose folinic acid: a case report and analysis of the literature.	[ [ "Methotrexate", "leukoencephalopathy" ] ]
After treatment with cimetidine, there was a rapid deterioration with decreased oxygen saturation and arterial PO2 values.	[ [ "cimetidine", "decreased oxygen saturation and arterial PO2" ] ]
An evaluation of ovarian structure and function should be considered in women of reproductive age being treated with valproate for epilepsy, especially if they develop menstrual cycle disturbances during treatment.	[ [ "valproate", "menstrual cycle disturbances" ] ]
Enalaprilat induced acute parotitis.	[ [ "Enalaprilat", "acute parotitis" ] ]
A patient suffering from a rare enzyme deficiency developed a malignant neuroleptic syndrome after having been treated with one single dose of haloperidol.	[ [ "haloperidol", "malignant neuroleptic syndrome" ] ]
Despite a postulated dopaminergic mechanism, there seems to have been only one previous report of amantadine's precipitating psychosis in a schizophrenic patient.	[ [ "amantadine", "precipitating psychosis" ] ]
Tardive dyskinesia in 2 patients treated with ziprasidone.	[ [ "ziprasidone", "Tardive dyskinesia" ] ]
Scleromyxedema in a patient with multiple sclerosis and monoclonal gammopathy on interferon beta-1a.	[ [ "interferon beta-1a", "Scleromyxedema" ] ]
We assume that rIFN-gamma induced the de novo development of SLE in our patient.	[ [ "rIFN-gamma", "SLE" ] ]
We report a patient receiving chronic lithium therapy who presented with a transient CDI occurring in the setting of underlying chronic NDI.	[ [ "lithium", "CDI" ] ]
A 64-year-old man with schizophrenia developed myoclonic jerks when given higher doses of quetiapine.	[ [ "quetiapine", "myoclonic jerks" ] ]
A 69-year-old man developed pure red cell aplasia after taking fenoprofen for ten months.	[ [ "fenoprofen", "pure red cell aplasia" ] ]
Retinal dysfunction and anterior segment deposits in a patient treated with rifabutin.	[ [ "rifabutin", "anterior segment deposits" ], [ "rifabutin", "Retinal dysfunction" ] ]
Restless legs syndrome may thus be an adverse effect of IFN alpha treatment.	[ [ "IFN alpha", "Restless legs syndrome" ] ]
Development of nephrotic syndrome in a patient with acute myeloblastic leukemia after treatment with macrophage-colony-stimulating factor.	[ [ "macrophage-colony-stimulating factor", "nephrotic syndrome" ] ]
A 21-year-old man with Tourette's syndrome, pedophilia, Asperger's syndrome, and multiple sclerosis experienced seizures after receiving therapy with interferon beta-1a.	[ [ "interferon beta-1a", "seizures" ] ]
Pulmonary hemorrhage is an uncommon feature in the HUS, and seems to appear especially in the HUS associated with MMC therapy.	[ [ "MMC", "HUS" ], [ "MMC", "Pulmonary hemorrhage" ] ]
Case report of withdrawal dyskinesia associated with amoxapine.	[ [ "amoxapine", "dyskinesia" ] ]
Thus, the possible in vivo effects of insulin on adipocytes were clearly observed in this case of insulin-induced lipohypertrophy.	[ [ "insulin", "lipohypertrophy" ] ]

Anaphylaxis after the injection of chymopapain occurs in about 1% of such cases.

[ [ "chymopapain", "Anaphylaxis" ] ]

Excluding other causes, Pentasa-associated pancytopenia was considered.

[ [ "Pentasa", "pancytopenia" ] ]

These findings suggest that clozapine-induced seizures can be successfully treated, that gradual dose titration can reduce the likelihood of further episodes of seizures and that concomitant use of a suitable mood stabilizer/anti-epileptic medication can improve the outcome of treatment-resistant schizophrenia.

[ [ "clozapine", "seizures" ] ]

While most physicians are aware of heparin-induced thrombocytopenia and skin necrosis, the association of heparin and hyperkalemia is less well recognized.

[ [ "heparin", "hyperkalemia" ], [ "heparin", "skin necrosis" ], [ "heparin", "thrombocytopenia" ] ]

The induced hyperglycaemia could not be controlled sufficiently, despite a high dose of insulin (> 110 units/day), suggesting the existence of insulin insensitivity and hyperinsulinaemia.

[ [ "insulin", "hyperinsulinaemia" ], [ "insulin", "insulin insensitivity" ] ]

Five days after the fourth dose of vincristine, she presented with bilateral ptosis.

[ [ "vincristine", "bilateral ptosis" ] ]

The typical fluoxetine-induced symptoms of restlessness, constant pacing, purposeless movements of the feet and legs, and marked anxiety were indistinguishable from those of neuroleptic-induced akathisia.

[ [ "fluoxetine", "purposeless movements of the feet and legs" ], [ "fluoxetine", "restlessness" ], [ "fluoxetine", "constant pacing" ], [ "fluoxetine", "marked anxiety" ] ]

Levofloxacin-induced delirium with psychotic features.

[ [ "Levofloxacin", "delirium with psychotic features" ] ]

We are concerned that the macular lesion was a retinal toxic effect of gentamicin because of the recent description of similar lesions occurring after the inadvertent intraocular injection of massive doses of this drug.

[ [ "gentamicin", "macular lesion" ] ]

After the addition of citalopram, a desmethylclomipramine plasma level increase and an 8-hydroacy-desmethylclomipramine plasma level decrease were observed.

[ [ "citalopram", "desmethylclomipramine plasma level increase" ], [ "citalopram", "8-hydroacy-desmethylclomipramine plasma level decrease" ] ]

Eosinophilia caused by clozapine was observed in challenge, preceded by a faster neutrophil production and consecutive decrease (z = 2.27, p = 0.01).

[ [ "clozapine", "Eosinophilia" ] ]

This supports the well-reported potential of bleomycin to trigger acral vascular toxicity.

[ [ "bleomycin", "acral vascular toxicity" ] ]

An infant girl with choanal atresia, athelia, minor anomalies, and mild to moderate mental retardation was born to a woman treated for hyperthyroidism throughout pregnancy with methimazole and propranolol.

[ [ "propranolol", "athelia" ], [ "methimazole", "mental retardation" ], [ "propranolol", "choanal atresia" ], [ "methimazole", "choanal atresia" ], [ "methimazole", "athelia" ], [ "propranolol", "mental retardation" ] ]

CONCLUSIONS: Although mirtazapine offers clinicians a combination of strong efficacy and good safety, we suggest bearing SS in mind when prescribing this drug, especially in frail, elderly patients with underlying chronic conditions.

[ [ "mirtazapine", "SS" ] ]

Several such HBV reactivations were reported after combined rituximab and multiagent chemotherapy for B-cell lymphomas.

[ [ "rituximab", "HBV reactivations" ] ]

We report the first case of a human immunodeficiency virus type 1 (HIV-1)-infected individual receiving combination antiretroviral therapy, which included ritonavir, who developed Cushing syndrome with profound complications after epidural triamcinolone injections.

[ [ "triamcinolone", "Cushing syndrome" ] ]

METHOD: Case analysis of a poly-drug overdose (venlafaxine, topiramate, divalproex sodium, risperidone, and carbamazepine) presenting with mixed SS/NMS features and whose clinical management suggests a practical algorithm for treatment of undifferentiated SS/NMS in critical care settings.

[ [ "risperidone", "SS" ], [ "divalproex sodium", "SS" ], [ "venlafaxine", "SS" ], [ "carbamazepine", "NMS" ], [ "topiramate", "SS" ], [ "risperidone", "NMS" ], [ "venlafaxine", "NMS" ], [ "divalproex sodium", "NMS" ], [ "topiramate", "NMS" ], [ "carbamazepine", "SS" ] ]

Transient phenytoin induced IgA deficiency and permanent IgE increase.

[ [ "phenytoin", "IgA deficiency" ], [ "phenytoin", "IgE increase" ] ]

Cutaneous eruptions occur in 3% of individuals administered carbamazepine.

[ [ "carbamazepine", "Cutaneous eruptions" ] ]

This sulfonamide like nephropathy should be differentiated from acetazolamide-related calcium phosphate nephrolithiasis.

[ [ "acetazolamide", "calcium phosphate nephrolithiasis" ] ]

The relation between tacrolimus treatment and staining was suggested by the appearance of pigmentation during topical tacrolimus treatment and its clinical disappearance when treatment was stopped.

[ [ "tacrolimus", "pigmentation" ] ]

We report an unusual case of simultaneous transitional cell carcinoma of the renal pelvis and distal ureter without transitional cell carcinoma of the bladder occurring after chronic cyclophosphamide therapy for nonHodgkin's lymphoma.

[ [ "cyclophosphamide", "transitional cell carcinoma of the renal pelvis" ], [ "cyclophosphamide", "distal ureter without transitional cell carcinoma of the bladder" ] ]

We report a case of secondary glaucoma caused by epithelial downgrowth in which filtration surgery was performed with adjunctive use of subconjunctival 5-fluorouracil.

[ [ "5-fluorouracil", "glaucoma" ] ]

Seizures associated with fluoxetine therapy are uncommon.

[ [ "fluoxetine", "Seizures" ] ]

However, each infant demonstrated hemodynamic decompensation shortly after verapamil administration and required cardiopulmonary resuscitation.

[ [ "verapamil", "hemodynamic decompensation" ] ]

We present a case of the syndrome of inappropriate antidiuretic hormone (SIADH) secondary to cisplatin therapy in a patient with advanced-stage large cell neuroendocrine carcinoma of the cervix.

[ [ "cisplatin", "syndrome of inappropriate antidiuretic hormone" ], [ "cisplatin", "SIADH" ] ]

The authors report five additional cases of capecitabine-induced multifocal leukoencephalopathy.

[ [ "capecitabine", "multifocal leukoencephalopathy" ] ]

A rare case of advanced ovarian carcinoma who developed difficulty walking 25 days after treatment with weekly paclitaxel.

[ [ "paclitaxel", "difficulty walking" ] ]

Esophageal spasm following propranolol overdose relieved by glucagon.

[ [ "propranolol", "Esophageal spasm" ] ]

We report three patients, all of whom had preexisting diabetic dyslipidemia, who showed a profound reduction in plasma HDL cholesterol and apolipoprotein AI levels soon after the initiation of rosiglitazone therapy.

[ [ "rosiglitazone", "reduction in plasma HDL cholesterol and apolipoprotein AI levels" ] ]

We hypothesize that caffeine toxicity injured the muscle cells, which were fragile due to the potassium depletion induced by the coexisting hyponatremia, to result in unusually severe rhabdomyolysis.

[ [ "caffeine", "rhabdomyolysis" ], [ "caffeine", "potassium depletion" ], [ "caffeine", "coexisting hyponatremia" ], [ "caffeine", "caffeine toxicity" ], [ "caffeine", "injured the muscle cells" ] ]

CONCLUSIONS: The observation that neurotoxicity developed with a delay of 24 to 48 hours after acyclovir peak serum concentrations could explain the wide range of acyclovir levels reported in similar cases.

[ [ "acyclovir", "neurotoxicity" ] ]

A 67-year-old patient, with primary polymyositis and without previous evidence of liver disease, developed clinical and biochemical features of severe cholestasis 3 months after initiation of azathioprine therapy.

[ [ "azathioprine", "severe cholestasis" ] ]

CONCLUSIONS: The piloerection observed after the replacement of fluvoxamine with milnacipran in this patient appears to have been due to an increase in the alpha(1)-adrenoceptor occupancy by endogenous norepinephrine induced by milnacipran.

[ [ "fluvoxamine", "piloerection" ], [ "milnacipran", "piloerection" ] ]

We report on a 14-year-old boy with severe haemophilia A who developed a portal vein thrombosis during continuous infusion of F VIII.

[ [ "F VIII", "portal vein thrombosis" ] ]

A 35-year-old man with seropositive rheumatoid arthritis developed selective IgA deficiency during treatment with fenclofenac.

[ [ "fenclofenac", "IgA deficiency" ] ]

A 74-year-old hypercholestrerolaemic woman taking cerivastatin (0.15 mg/day) for 22 days complained of general muscle weakness and muscle pain.

[ [ "cerivastatin", "muscle weakness" ], [ "cerivastatin", "muscle pain" ] ]

We describe two dark-skinned patients who developed hyperpigmented skin and tongue lesions during combination therapy with IFN and ribavirin.

[ [ "IFN", "tongue lesions" ], [ "ribavirin", "hyperpigmented skin" ], [ "IFN", "hyperpigmented skin" ], [ "ribavirin", "tongue lesions" ] ]

The second patient experienced mild nitritoid symptoms following several GSTM injections prior experiencing a cerebrovascular accident within several hours of her next injection.

[ [ "GSTM", "mild nitritoid symptoms" ] ]

In a phase II study of hycanthone in patients with breast cancer we have recently observed severe hepatotoxicity, even at lower doses, which resulted in two drug-related deaths.

[ [ "hycanthone", "severe hepatotoxicity" ] ]

A 40-year-old man with advanced HIV infection and Mycobacterium avium complex infection experienced rapid cognitive decline after commencement of ethambutol, and symptoms fully resolved with cessation.

[ [ "ethambutol", "rapid cognitive decline" ] ]

An apparent link is described between the use of MMF with prednisone to treat pemphigus vulgaris and the development of red blood cell anemia.

[ [ "prednisone", "red blood cell anemia" ], [ "MMF", "red blood cell anemia" ] ]

We report a case of a patient with pulmonary hypertension and undifferentiated connective tissue disease who, after 2 months of treatment with epoprostenol, presented with rapidly progressive erythema, scaling, nausea and vomiting, and fever.

[ [ "epoprostenol", "fever" ], [ "epoprostenol", "scaling" ], [ "epoprostenol", "vomiting" ], [ "epoprostenol", "rapidly progressive erythema" ], [ "epoprostenol", "nausea" ] ]

Hyperglycemia and diabetic coma: possible relationship to diuretic-propranolol therapy.

[ [ "propranolol", "Hyperglycemia" ], [ "propranolol", "diabetic coma" ] ]

Four weeks earlier she had developed hepatopathy during a regimen of carbamazepine, lynestrenol and sodium valproate.

[ [ "carbamazepine", "hepatopathy" ], [ "lynestrenol", "hepatopathy" ], [ "sodium valproate", "hepatopathy" ] ]

Recovery of the tubular dysfunction took 15 days following cessation of the offending drug, Amikacin.

[ [ "Amikacin", "tubular dysfunction" ] ]

We conclude that myocardial infarction may develop in patients treated with high-dose glucocorticoids for Graves' ophthalmopathy, and increased blood pressure may herald this complication.

[ [ "glucocorticoids", "myocardial infarction" ] ]

Hemorrhagic cystitis is a significant toxic effect of cyclophosphamide therapy.

[ [ "cyclophosphamide", "Hemorrhagic cystitis" ] ]

In some cases this seems to happen because spironolactone causes diarrhoea.

[ [ "spironolactone", "diarrhoea" ] ]

We report two patients with acne vulgaris with a fourth type of minocycline-induced cutaneous pigmentation.

[ [ "minocycline", "cutaneous pigmentation" ] ]

A case of severe acute hepatitis caused by cyproterone acetate in a 71 year old man with prostatic carcinoma is reported with a review of the literature on hepatic reactions to this drug.

[ [ "cyproterone acetate", "severe acute hepatitis" ] ]

CASE PRESENTATION: We report a patient with CF who developed recurrent eosinophilia and severe persistent bronchospasm following repeated administration of preservative-free tobramycin by inhalation, beginning at 16 months of age.

[ [ "tobramycin", "severe persistent bronchospasm" ], [ "tobramycin", "recurrent eosinophilia" ] ]

Peculiar nail-changes in a 70-year-old woman with rheumatoid arthritis occurring after approximately 1 year of penicillamine treatment are described.

[ [ "penicillamine", "nail-changes" ] ]

A severe form of exophthalmos resulting from lithium therapy has not been described in the literature.

[ [ "lithium", "exophthalmos" ] ]

Disseminated eruptive giant mollusca contagiosa in an adult psoriasis patient during efalizumab therapy.

[ [ "efalizumab", "Disseminated eruptive giant mollusca contagiosa" ] ]

Myoclonus and seizures in a patient with parkinsonism: induction by levodopa and its confirmation on SEPs.

[ [ "levodopa", "Myoclonus" ], [ "levodopa", "seizures" ] ]

Cutaneous seeding after ultrasound-guided percutaneous ethanol injection for treatment of hepatocellular carcinoma.

[ [ "ethanol injection", "Cutaneous seeding" ] ]

Neurologic symptoms resolved after stopping CAP for 4 weeks in Patient A, with no recurrence after reinitiating CAP alone at 2000 mg/m2.

[ [ "CAP", "Neurologic symptoms" ] ]

After therapy for diabetic coma with insulin (containing the preservative cresol) and electrolyte solutions was started, the patient complained of increasing myalgia, developed a high fever and respiratory and metabolic acidosis and lost consciousness.

[ [ "insulin", "lost consciousness" ], [ "cresol", "lost consciousness" ], [ "insulin", "respiratory and metabolic acidosis" ], [ "cresol", "increasing myalgia" ], [ "cresol", "respiratory and metabolic acidosis" ], [ "cresol", "high fever" ], [ "insulin", "increasing myalgia" ], [ "insulin", "high fever" ] ]

Only a few reports of overt jaundice are associated with streptokinase.

[ [ "streptokinase", "jaundice" ] ]

Heat stroke-like episode in a child caused by zonisamide.

[ [ "zonisamide", "Heat stroke-like episode" ] ]

The chemotherapeutics, including vincristine, actinomycin D, and epirubicin in case 1 and vincristine and actinomycin D in case 2, were given before the hepatotoxicity developed.

[ [ "actinomycin D", "hepatotoxicity" ], [ "vincristine", "hepatotoxicity" ], [ "epirubicin", "hepatotoxicity" ] ]

In this paper, we report a patient with primary anti-phospholipid syndrome treated by corticosteroid, who developed disseminated nocardiosis.

[ [ "corticosteroid", "disseminated nocardiosis" ] ]

It was concluded that ANCA is closely related to the pathogenesis of crescentic glomerulonephritis and that treatment with PTU appeared to induce ANCA.

[ [ "PTU", "ANCA" ] ]

Here we present the case of a generalized lichen nitidus with involvement of the palms in a patient with hepatitis C after systemic treatment with interferon alpha and ribavirin.

[ [ "interferon alpha", "generalized lichen nitidus" ], [ "ribavirin", "generalized lichen nitidus" ] ]

Insulin-induced lipoatrophy in type I diabetes.

[ [ "Insulin", "lipoatrophy" ] ]

To date, this is the first reported case of what appears to be isolated thrombocytopenia associated with lansoprazole.

[ [ "lansoprazole", "thrombocytopenia" ] ]

The case histories are presented of two patients who developed lung disease associated with the use of nitrofurantoin with histological features of bronchiolitis obliterans organising pneumonia (BOOP), a rare but recognised form of drug induced injury.

[ [ "nitrofurantoin", "lung disease" ], [ "nitrofurantoin", "BOOP" ], [ "nitrofurantoin", "bronchiolitis obliterans organising pneumonia" ] ]

Acute respiratory distress syndrome after rituximab infusion.

[ [ "rituximab", "Acute respiratory distress syndrome" ] ]

We report an HIV-infected woman who developed mild leukopenia as the first sign of a nevirapine-related adverse event, which was followed by skin and hepatic toxicity associated with a more severe leukopenia.

[ [ "nevirapine", "skin and hepatic toxicity" ], [ "nevirapine", "leukopenia" ] ]

Apparent cyclophosphamide (cytoxan) embryopathy: a distinct phenotype?

[ [ "cyclophosphamide", "embryopathy" ] ]

Drug-induced fever should be considered in patients who have unexplained high temperatures during diltiazem therapy.

[ [ "diltiazem", "fever" ] ]

A unique case of a transient, nonpigmenting fixed drug eruption caused by the radiopaque contrast medium iothalamate is reported.

[ [ "iothalamate", "fixed drug eruption" ] ]

She received an accidental 450-mg bolus injection of morphine intrathecally and developed hypertension, status epilepticus, intracerebral hemorrhage, and respiratory failure.

[ [ "morphine", "intracerebral hemorrhage" ], [ "morphine", "status epilepticus" ], [ "morphine", "respiratory failure" ], [ "morphine", "hypertension" ] ]

CD20-negative T-cell-rich B-cell lymphoma as a progression of a nodular lymphocyte-predominant Hodgkin's lymphoma treated with rituximab: a molecular analysis using laser capture microdissection.

[ [ "rituximab", "CD20-negative T-cell-rich B-cell lymphoma" ] ]

Five patients are described in whom only gentamicin sulfate appeared responsible for acute renal failure.

[ [ "gentamicin sulfate", "acute renal failure" ] ]

Similar to reports in patients receiving gefitinib, those with pathologic findings of UIP on resected lung specimens or known pulmonary fibrosis may be at particular risk for erlotinib pulmonary toxicity.

[ [ "erlotinib", "pulmonary fibrosis" ], [ "erlotinib", "pulmonary toxicity" ] ]

Pemphigus vulgaris precipitated by glibenclamide therapy.

[ [ "glibenclamide", "Pemphigus vulgaris" ] ]

Trichiasis associated with prostaglandin analog use.

[ [ "prostaglandin", "Trichiasis" ] ]

OBSERVATIONS: We observed aggravation and spreading of a psoriatic plaque when treated topically with the toll-like receptor (TLR) 7 agonist imiquimod.

[ [ "imiquimod", "aggravation and spreading of a psoriatic plaque" ] ]

A case of congestive heart failure in a child with Wilms' tumor treated Adriamycin is presented and discussed.

[ [ "Adriamycin", "congestive heart failure" ] ]

Methotrexate-induced leukoencephalopathy is treatable with high-dose folinic acid: a case report and analysis of the literature.

[ [ "Methotrexate", "leukoencephalopathy" ] ]

After treatment with cimetidine, there was a rapid deterioration with decreased oxygen saturation and arterial PO2 values.

[ [ "cimetidine", "decreased oxygen saturation and arterial PO2" ] ]

An evaluation of ovarian structure and function should be considered in women of reproductive age being treated with valproate for epilepsy, especially if they develop menstrual cycle disturbances during treatment.

[ [ "valproate", "menstrual cycle disturbances" ] ]

Enalaprilat induced acute parotitis.

[ [ "Enalaprilat", "acute parotitis" ] ]

A patient suffering from a rare enzyme deficiency developed a malignant neuroleptic syndrome after having been treated with one single dose of haloperidol.

[ [ "haloperidol", "malignant neuroleptic syndrome" ] ]

Despite a postulated dopaminergic mechanism, there seems to have been only one previous report of amantadine's precipitating psychosis in a schizophrenic patient.

[ [ "amantadine", "precipitating psychosis" ] ]

Tardive dyskinesia in 2 patients treated with ziprasidone.

[ [ "ziprasidone", "Tardive dyskinesia" ] ]

Scleromyxedema in a patient with multiple sclerosis and monoclonal gammopathy on interferon beta-1a.

[ [ "interferon beta-1a", "Scleromyxedema" ] ]

We assume that rIFN-gamma induced the de novo development of SLE in our patient.

[ [ "rIFN-gamma", "SLE" ] ]

We report a patient receiving chronic lithium therapy who presented with a transient CDI occurring in the setting of underlying chronic NDI.

[ [ "lithium", "CDI" ] ]

A 64-year-old man with schizophrenia developed myoclonic jerks when given higher doses of quetiapine.

[ [ "quetiapine", "myoclonic jerks" ] ]

A 69-year-old man developed pure red cell aplasia after taking fenoprofen for ten months.

[ [ "fenoprofen", "pure red cell aplasia" ] ]

Retinal dysfunction and anterior segment deposits in a patient treated with rifabutin.

[ [ "rifabutin", "anterior segment deposits" ], [ "rifabutin", "Retinal dysfunction" ] ]

Restless legs syndrome may thus be an adverse effect of IFN alpha treatment.

[ [ "IFN alpha", "Restless legs syndrome" ] ]

Development of nephrotic syndrome in a patient with acute myeloblastic leukemia after treatment with macrophage-colony-stimulating factor.

[ [ "macrophage-colony-stimulating factor", "nephrotic syndrome" ] ]

A 21-year-old man with Tourette's syndrome, pedophilia, Asperger's syndrome, and multiple sclerosis experienced seizures after receiving therapy with interferon beta-1a.

[ [ "interferon beta-1a", "seizures" ] ]

Pulmonary hemorrhage is an uncommon feature in the HUS, and seems to appear especially in the HUS associated with MMC therapy.

[ [ "MMC", "HUS" ], [ "MMC", "Pulmonary hemorrhage" ] ]

Case report of withdrawal dyskinesia associated with amoxapine.

[ [ "amoxapine", "dyskinesia" ] ]

Thus, the possible in vivo effects of insulin on adipocytes were clearly observed in this case of insulin-induced lipohypertrophy.

[ [ "insulin", "lipohypertrophy" ] ]