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Etoposide-related myocardial infarction.
|
[
{
"ade": "myocardial infarction",
"drug": "Etoposide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Etoposide-related myocardial infarction.",
"role": "user"
},
{
"content": "[{'ade': 'myocardial infarction', 'drug': 'Etoposide'}]",
"role": "assistant"
}
] |
Case studies in heparin-induced thrombocytopenia.
|
[
{
"ade": "thrombocytopenia",
"drug": "heparin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Case studies in heparin-induced thrombocytopenia.",
"role": "user"
},
{
"content": "[{'ade': 'thrombocytopenia', 'drug': 'heparin'}]",
"role": "assistant"
}
] |
We report the first case of chlorambucil-induced DRESS syndrome in a 70-year-old man recently diagnosed with chronic lymphocytic leukaemia.
|
[
{
"ade": "DRESS syndrome",
"drug": "chlorambucil"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We report the first case of chlorambucil-induced DRESS syndrome in a 70-year-old man recently diagnosed with chronic lymphocytic leukaemia.",
"role": "user"
},
{
"content": "[{'ade': 'DRESS syndrome', 'drug': 'chlorambucil'}]",
"role": "assistant"
}
] |
The cases of CBZ-induced SLE reported in the literature were reviewed.
|
[
{
"ade": "SLE",
"drug": "CBZ"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The cases of CBZ-induced SLE reported in the literature were reviewed.",
"role": "user"
},
{
"content": "[{'ade': 'SLE', 'drug': 'CBZ'}]",
"role": "assistant"
}
] |
The increasing prevalence of methamphetamine abuse and the severity of the associated ulcers should alert ophthalmologists to the problem of methamphetamine-related keratitis.
|
[
{
"ade": "keratitis",
"drug": "methamphetamine"
},
{
"ade": "ulcers",
"drug": "methamphetamine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The increasing prevalence of methamphetamine abuse and the severity of the associated ulcers should alert ophthalmologists to the problem of methamphetamine-related keratitis.",
"role": "user"
},
{
"content": "[{'ade': 'keratitis', 'drug': 'methamphetamine'}, {'ade': 'ulcers', 'drug': 'methamphetamine'}]",
"role": "assistant"
}
] |
Linezolid-induced dyserythropoiesis: chloramphenicol toxicity revisited.
|
[
{
"ade": "dyserythropoiesis",
"drug": "Linezolid"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Linezolid-induced dyserythropoiesis: chloramphenicol toxicity revisited.",
"role": "user"
},
{
"content": "[{'ade': 'dyserythropoiesis', 'drug': 'Linezolid'}]",
"role": "assistant"
}
] |
Methemoglobinemia: an occupational hazard of phenylpropanolamine production.
|
[
{
"ade": "Methemoglobinemia",
"drug": "phenylpropanolamine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Methemoglobinemia: an occupational hazard of phenylpropanolamine production.",
"role": "user"
},
{
"content": "[{'ade': 'Methemoglobinemia', 'drug': 'phenylpropanolamine'}]",
"role": "assistant"
}
] |
Bilateral acoustic (VIII) nerve palsy in this patient was most likely a manifestation of vincristine neurotoxicity.
|
[
{
"ade": "neurotoxicity",
"drug": "vincristine"
},
{
"ade": "Bilateral acoustic (VIII) nerve palsy",
"drug": "vincristine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Bilateral acoustic (VIII) nerve palsy in this patient was most likely a manifestation of vincristine neurotoxicity.",
"role": "user"
},
{
"content": "[{'ade': 'neurotoxicity', 'drug': 'vincristine'}, {'ade': 'Bilateral acoustic (VIII) nerve palsy', 'drug': 'vincristine'}]",
"role": "assistant"
}
] |
Tumor lysis syndrome after transcatheter arterial infusion of cisplatin and embolization therapy for liver metastases of melanoma.
|
[
{
"ade": "Tumor lysis syndrome",
"drug": "cisplatin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Tumor lysis syndrome after transcatheter arterial infusion of cisplatin and embolization therapy for liver metastases of melanoma.",
"role": "user"
},
{
"content": "[{'ade': 'Tumor lysis syndrome', 'drug': 'cisplatin'}]",
"role": "assistant"
}
] |
Acute renal failure with severe tubulointerstitial changes in a patient with minimal change nephrotic syndrome treated with enalapril.
|
[
{
"ade": "severe tubulointerstitial changes",
"drug": "enalapril"
},
{
"ade": "Acute renal failure",
"drug": "enalapril"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Acute renal failure with severe tubulointerstitial changes in a patient with minimal change nephrotic syndrome treated with enalapril.",
"role": "user"
},
{
"content": "[{'ade': 'severe tubulointerstitial changes', 'drug': 'enalapril'}, {'ade': 'Acute renal failure', 'drug': 'enalapril'}]",
"role": "assistant"
}
] |
Ibopamine-induced reversible leukopenia during treatment for congestive heart failure.
|
[
{
"ade": "leukopenia",
"drug": "Ibopamine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Ibopamine-induced reversible leukopenia during treatment for congestive heart failure.",
"role": "user"
},
{
"content": "[{'ade': 'leukopenia', 'drug': 'Ibopamine'}]",
"role": "assistant"
}
] |
NMS is a drug-related response to various medications, such as Haloperidol, which the patient was receiving.
|
[
{
"ade": "NMS",
"drug": "Haloperidol"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: NMS is a drug-related response to various medications, such as Haloperidol, which the patient was receiving.",
"role": "user"
},
{
"content": "[{'ade': 'NMS', 'drug': 'Haloperidol'}]",
"role": "assistant"
}
] |
We describe 2 patients with severe erosive rheumatoid arthritis and rheumatoid vasculitis, respectively, in whom infliximab therapy was associated with peripheral neuropathy due to necrotizing vasculitis in one patient and to progression of preexisting mononeuritis multiplex in the other.
|
[
{
"ade": "necrotizing vasculitis",
"drug": "infliximab"
},
{
"ade": "peripheral neuropathy",
"drug": "infliximab"
},
{
"ade": "progression of preexisting mononeuritis multiplex",
"drug": "infliximab"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We describe 2 patients with severe erosive rheumatoid arthritis and rheumatoid vasculitis, respectively, in whom infliximab therapy was associated with peripheral neuropathy due to necrotizing vasculitis in one patient and to progression of preexisting mononeuritis multiplex in the other.",
"role": "user"
},
{
"content": "[{'ade': 'necrotizing vasculitis', 'drug': 'infliximab'}, {'ade': 'peripheral neuropathy', 'drug': 'infliximab'}, {'ade': 'progression of preexisting mononeuritis multiplex', 'drug': 'infliximab'}]",
"role": "assistant"
}
] |
She developed neurotoxicity with an adjustment dosage of valacyclovir for a cutaneous zoster infection.
|
[
{
"ade": "neurotoxicity",
"drug": "valacyclovir"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: She developed neurotoxicity with an adjustment dosage of valacyclovir for a cutaneous zoster infection.",
"role": "user"
},
{
"content": "[{'ade': 'neurotoxicity', 'drug': 'valacyclovir'}]",
"role": "assistant"
}
] |
CONCLUSION: Anterior ischemic optic neuropathy may complicate treatment with interferon alfa.
|
[
{
"ade": "Anterior ischemic optic neuropathy",
"drug": "interferon alfa"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: CONCLUSION: Anterior ischemic optic neuropathy may complicate treatment with interferon alfa.",
"role": "user"
},
{
"content": "[{'ade': 'Anterior ischemic optic neuropathy', 'drug': 'interferon alfa'}]",
"role": "assistant"
}
] |
Increased libido in a woman treated with fluvoxamine: a case report.
|
[
{
"ade": "Increased libido",
"drug": "fluvoxamine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Increased libido in a woman treated with fluvoxamine: a case report.",
"role": "user"
},
{
"content": "[{'ade': 'Increased libido', 'drug': 'fluvoxamine'}]",
"role": "assistant"
}
] |
To our knowledge, no prior cases of penicillamine-induced TTP in RA have been reported.
|
[
{
"ade": "TTP",
"drug": "penicillamine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: To our knowledge, no prior cases of penicillamine-induced TTP in RA have been reported.",
"role": "user"
},
{
"content": "[{'ade': 'TTP', 'drug': 'penicillamine'}]",
"role": "assistant"
}
] |
Vancomycin is the most frequently implicated drug, but other agents have been reported to cause LABD.
|
[
{
"ade": "LABD",
"drug": "Vancomycin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Vancomycin is the most frequently implicated drug, but other agents have been reported to cause LABD.",
"role": "user"
},
{
"content": "[{'ade': 'LABD', 'drug': 'Vancomycin'}]",
"role": "assistant"
}
] |
The patient was initially treated with hydration and furosemide but developed congestive heart failure.
|
[
{
"ade": "congestive heart failure",
"drug": "furosemide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The patient was initially treated with hydration and furosemide but developed congestive heart failure.",
"role": "user"
},
{
"content": "[{'ade': 'congestive heart failure', 'drug': 'furosemide'}]",
"role": "assistant"
}
] |
We report a case of hypoglycaemia after mefloquine therapy (1,500 mg over two days) for severe gastrointestinal cryptosporidiasis in a cachectic AIDS patient with protracted diarrhoea.
|
[
{
"ade": "hypoglycaemia",
"drug": "mefloquine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We report a case of hypoglycaemia after mefloquine therapy (1,500 mg over two days) for severe gastrointestinal cryptosporidiasis in a cachectic AIDS patient with protracted diarrhoea.",
"role": "user"
},
{
"content": "[{'ade': 'hypoglycaemia', 'drug': 'mefloquine'}]",
"role": "assistant"
}
] |
The most common side effects associated with amifostine are nausea, vomiting, hypotension, hypocalcemia and allergic reactions.
|
[
{
"ade": "nausea",
"drug": "amifostine"
},
{
"ade": "hypocalcemia",
"drug": "amifostine"
},
{
"ade": "vomiting",
"drug": "amifostine"
},
{
"ade": "allergic reactions",
"drug": "amifostine"
},
{
"ade": "hypotension",
"drug": "amifostine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The most common side effects associated with amifostine are nausea, vomiting, hypotension, hypocalcemia and allergic reactions.",
"role": "user"
},
{
"content": "[{'ade': 'nausea', 'drug': 'amifostine'}, {'ade': 'hypocalcemia', 'drug': 'amifostine'}, {'ade': 'vomiting', 'drug': 'amifostine'}, {'ade': 'allergic reactions', 'drug': 'amifostine'}, {'ade': 'hypotension', 'drug': 'amifostine'}]",
"role": "assistant"
}
] |
In 2 of the 3 cases the patients were also taking lithium carbonate and beta-blockers, both of which could have contributed to the incontinence.
|
[
{
"ade": "incontinence",
"drug": "lithium carbonate"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: In 2 of the 3 cases the patients were also taking lithium carbonate and beta-blockers, both of which could have contributed to the incontinence.",
"role": "user"
},
{
"content": "[{'ade': 'incontinence', 'drug': 'lithium carbonate'}]",
"role": "assistant"
}
] |
This report suggests that bleomycin lung toxicity may be reversible if treated aggressively.
|
[
{
"ade": "lung toxicity",
"drug": "bleomycin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: This report suggests that bleomycin lung toxicity may be reversible if treated aggressively.",
"role": "user"
},
{
"content": "[{'ade': 'lung toxicity', 'drug': 'bleomycin'}]",
"role": "assistant"
}
] |
The events of non-convulsive status epilepticus subsided following reduction in tiagabine dosages.
|
[
{
"ade": "non-convulsive status epilepticus",
"drug": "tiagabine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The events of non-convulsive status epilepticus subsided following reduction in tiagabine dosages.",
"role": "user"
},
{
"content": "[{'ade': 'non-convulsive status epilepticus', 'drug': 'tiagabine'}]",
"role": "assistant"
}
] |
The case of a 4-year-old girl with valproate-induced stupor and electroencephalographic pattern of increased fast activity is reported.
|
[
{
"ade": "stupor",
"drug": "valproate"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The case of a 4-year-old girl with valproate-induced stupor and electroencephalographic pattern of increased fast activity is reported.",
"role": "user"
},
{
"content": "[{'ade': 'stupor', 'drug': 'valproate'}]",
"role": "assistant"
}
] |
Loperamide poisoning in the dog.
|
[
{
"ade": "Loperamide poisoning",
"drug": "Loperamide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Loperamide poisoning in the dog.",
"role": "user"
},
{
"content": "[{'ade': 'Loperamide poisoning', 'drug': 'Loperamide'}]",
"role": "assistant"
}
] |
A 22-year-old drug-abuser injected flunitrazepam tablets dissolved in tap water into her left femoral artery and presented with clinical signs of acute ischaemia of the left leg.
|
[
{
"ade": "acute ischaemia of the left leg",
"drug": "flunitrazepam"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A 22-year-old drug-abuser injected flunitrazepam tablets dissolved in tap water into her left femoral artery and presented with clinical signs of acute ischaemia of the left leg.",
"role": "user"
},
{
"content": "[{'ade': 'acute ischaemia of the left leg', 'drug': 'flunitrazepam'}]",
"role": "assistant"
}
] |
Probable propafenone-induced transient global amnesia.
|
[
{
"ade": "transient global amnesia",
"drug": "propafenone"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Probable propafenone-induced transient global amnesia.",
"role": "user"
},
{
"content": "[{'ade': 'transient global amnesia', 'drug': 'propafenone'}]",
"role": "assistant"
}
] |
This case represents the third example of erythroid aplasia associated with an anti-inflammatory agent and the first instance due to fenoprofen.
|
[
{
"ade": "erythroid aplasia",
"drug": "fenoprofen"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: This case represents the third example of erythroid aplasia associated with an anti-inflammatory agent and the first instance due to fenoprofen.",
"role": "user"
},
{
"content": "[{'ade': 'erythroid aplasia', 'drug': 'fenoprofen'}]",
"role": "assistant"
}
] |
CONCLUSIONS: The value of multihormonal therapy in breast carcinoma is not established, and the addition of progestogens to tamoxifen may not reduce of developing endometrial lesions, including carcinoma.
|
[
{
"ade": "carcinoma",
"drug": "tamoxifen"
},
{
"ade": "endometrial lesions",
"drug": "tamoxifen"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: CONCLUSIONS: The value of multihormonal therapy in breast carcinoma is not established, and the addition of progestogens to tamoxifen may not reduce of developing endometrial lesions, including carcinoma.",
"role": "user"
},
{
"content": "[{'ade': 'carcinoma', 'drug': 'tamoxifen'}, {'ade': 'endometrial lesions', 'drug': 'tamoxifen'}]",
"role": "assistant"
}
] |
Hypokalemia after normal doses of neubulized albuterol (salbutamol).
|
[
{
"ade": "Hypokalemia",
"drug": "salbutamol"
},
{
"ade": "Hypokalemia",
"drug": "albuterol"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Hypokalemia after normal doses of neubulized albuterol (salbutamol).",
"role": "user"
},
{
"content": "[{'ade': 'Hypokalemia', 'drug': 'salbutamol'}, {'ade': 'Hypokalemia', 'drug': 'albuterol'}]",
"role": "assistant"
}
] |
We report the case of a 43-year-old man with ITP refractory to steroids and intravenous immunoglobulin who developed acute respiratory distress syndrome (ARDS) after a single infusion of rituximab.
|
[
{
"ade": "acute respiratory distress syndrome",
"drug": "rituximab"
},
{
"ade": "ARDS",
"drug": "rituximab"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We report the case of a 43-year-old man with ITP refractory to steroids and intravenous immunoglobulin who developed acute respiratory distress syndrome (ARDS) after a single infusion of rituximab.",
"role": "user"
},
{
"content": "[{'ade': 'acute respiratory distress syndrome', 'drug': 'rituximab'}, {'ade': 'ARDS', 'drug': 'rituximab'}]",
"role": "assistant"
}
] |
It is concluded that SIADH is an important side effect of lorcainide therapy.
|
[
{
"ade": "SIADH",
"drug": "lorcainide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: It is concluded that SIADH is an important side effect of lorcainide therapy.",
"role": "user"
},
{
"content": "[{'ade': 'SIADH', 'drug': 'lorcainide'}]",
"role": "assistant"
}
] |
In summary, we report herein the first case of SIADH believed to be an adverse effect of mizoribin, which may therefore needed to be added to the list of drugs which can induce SIADH.
|
[
{
"ade": "SIADH",
"drug": "mizoribin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: In summary, we report herein the first case of SIADH believed to be an adverse effect of mizoribin, which may therefore needed to be added to the list of drugs which can induce SIADH.",
"role": "user"
},
{
"content": "[{'ade': 'SIADH', 'drug': 'mizoribin'}]",
"role": "assistant"
}
] |
The patient whose case is reviewed had migraine headaches and received methysergide maleate for 13 years.
|
[
{
"ade": "migraine headaches",
"drug": "methysergide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The patient whose case is reviewed had migraine headaches and received methysergide maleate for 13 years.",
"role": "user"
},
{
"content": "[{'ade': 'migraine headaches', 'drug': 'methysergide'}]",
"role": "assistant"
}
] |
Exacerbation of schizophrenia associated with amantadine.
|
[
{
"ade": "schizophrenia",
"drug": "amantadine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Exacerbation of schizophrenia associated with amantadine.",
"role": "user"
},
{
"content": "[{'ade': 'schizophrenia', 'drug': 'amantadine'}]",
"role": "assistant"
}
] |
Disulfiram-induced hepatitis.
|
[
{
"ade": "hepatitis",
"drug": "Disulfiram"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Disulfiram-induced hepatitis.",
"role": "user"
},
{
"content": "[{'ade': 'hepatitis', 'drug': 'Disulfiram'}]",
"role": "assistant"
}
] |
It is tempting to speculate that interferon alpha may be involved in the pathogenesis of lichen nitidus.
|
[
{
"ade": "lichen nitidus",
"drug": "interferon alpha"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: It is tempting to speculate that interferon alpha may be involved in the pathogenesis of lichen nitidus.",
"role": "user"
},
{
"content": "[{'ade': 'lichen nitidus', 'drug': 'interferon alpha'}]",
"role": "assistant"
}
] |
Our cases constitute the most severe cases of benzarone hepatotoxicity reported so far, and comprise the first cases of (sub)fulminant hepatitis and cirrhosis related to benzarone.
|
[
{
"ade": "hepatotoxicity",
"drug": "benzarone"
},
{
"ade": "cirrhosis",
"drug": "benzarone"
},
{
"ade": "(sub)fulminant hepatitis",
"drug": "benzarone"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Our cases constitute the most severe cases of benzarone hepatotoxicity reported so far, and comprise the first cases of (sub)fulminant hepatitis and cirrhosis related to benzarone.",
"role": "user"
},
{
"content": "[{'ade': 'hepatotoxicity', 'drug': 'benzarone'}, {'ade': 'cirrhosis', 'drug': 'benzarone'}, {'ade': '(sub)fulminant hepatitis', 'drug': 'benzarone'}]",
"role": "assistant"
}
] |
CONCLUSION: Atovaquone should be added to the list of agents causing vortex keratopathy involving the corneal epithelium.
|
[
{
"ade": "vortex keratopathy",
"drug": "Atovaquone"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: CONCLUSION: Atovaquone should be added to the list of agents causing vortex keratopathy involving the corneal epithelium.",
"role": "user"
},
{
"content": "[{'ade': 'vortex keratopathy', 'drug': 'Atovaquone'}]",
"role": "assistant"
}
] |
We stress the potential of benzarone to cause hepatotoxicity, which usually resembles severe chronic active hepatitis.
|
[
{
"ade": "hepatotoxicity",
"drug": "benzarone"
},
{
"ade": "severe chronic active hepatitis",
"drug": "benzarone"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We stress the potential of benzarone to cause hepatotoxicity, which usually resembles severe chronic active hepatitis.",
"role": "user"
},
{
"content": "[{'ade': 'hepatotoxicity', 'drug': 'benzarone'}, {'ade': 'severe chronic active hepatitis', 'drug': 'benzarone'}]",
"role": "assistant"
}
] |
Insulin-dependent diabetes mellitus developed in a young woman 8 weeks after the initiation of danazol for treatment of pelvic endometriosis.
|
[
{
"ade": "Insulin-dependent diabetes mellitus",
"drug": "danazol"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Insulin-dependent diabetes mellitus developed in a young woman 8 weeks after the initiation of danazol for treatment of pelvic endometriosis.",
"role": "user"
},
{
"content": "[{'ade': 'Insulin-dependent diabetes mellitus', 'drug': 'danazol'}]",
"role": "assistant"
}
] |
Insulin-induced cardiac failure.
|
[
{
"ade": "cardiac failure",
"drug": "Insulin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Insulin-induced cardiac failure.",
"role": "user"
},
{
"content": "[{'ade': 'cardiac failure', 'drug': 'Insulin'}]",
"role": "assistant"
}
] |
Gemcitabine-induced pulmonary toxicity is usually a dramatic condition.
|
[
{
"ade": "pulmonary toxicity",
"drug": "Gemcitabine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Gemcitabine-induced pulmonary toxicity is usually a dramatic condition.",
"role": "user"
},
{
"content": "[{'ade': 'pulmonary toxicity', 'drug': 'Gemcitabine'}]",
"role": "assistant"
}
] |
Dipyrone, also known as metamizole, is an analgesic and antipyretic drug that was banned by the United States Food and Drug Administration because of its association with agranulocytosis.
|
[
{
"ade": "agranulocytosis",
"drug": "metamizole"
},
{
"ade": "agranulocytosis",
"drug": "Dipyrone"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Dipyrone, also known as metamizole, is an analgesic and antipyretic drug that was banned by the United States Food and Drug Administration because of its association with agranulocytosis.",
"role": "user"
},
{
"content": "[{'ade': 'agranulocytosis', 'drug': 'metamizole'}, {'ade': 'agranulocytosis', 'drug': 'Dipyrone'}]",
"role": "assistant"
}
] |
Gabapentin toxicity in renal failure: the importance of dose adjustment.
|
[
{
"ade": "renal failure",
"drug": "Gabapentin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Gabapentin toxicity in renal failure: the importance of dose adjustment.",
"role": "user"
},
{
"content": "[{'ade': 'renal failure', 'drug': 'Gabapentin'}]",
"role": "assistant"
}
] |
Herein, we describe 2 patients who developed unusual CD8+ cutaneous lymphoproliferative disorders after treatment with efalizumab and infliximab.
|
[
{
"ade": "CD8+ cutaneous lymphoproliferative disorders",
"drug": "efalizumab"
},
{
"ade": "CD8+ cutaneous lymphoproliferative disorders",
"drug": "infliximab"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Herein, we describe 2 patients who developed unusual CD8+ cutaneous lymphoproliferative disorders after treatment with efalizumab and infliximab.",
"role": "user"
},
{
"content": "[{'ade': 'CD8+ cutaneous lymphoproliferative disorders', 'drug': 'efalizumab'}, {'ade': 'CD8+ cutaneous lymphoproliferative disorders', 'drug': 'infliximab'}]",
"role": "assistant"
}
] |
We report the case of a 40-year-old woman who developed fulminant hepatic failure and aplastic anaemia following a course of oral flucloxacillin.
|
[
{
"ade": "fulminant hepatic failure",
"drug": "flucloxacillin"
},
{
"ade": "aplastic anaemia",
"drug": "flucloxacillin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We report the case of a 40-year-old woman who developed fulminant hepatic failure and aplastic anaemia following a course of oral flucloxacillin.",
"role": "user"
},
{
"content": "[{'ade': 'fulminant hepatic failure', 'drug': 'flucloxacillin'}, {'ade': 'aplastic anaemia', 'drug': 'flucloxacillin'}]",
"role": "assistant"
}
] |
A diagnosis of masked theophylline poisoning should be considered in similar situations involving a rapid decrease of insulin requirements.
|
[
{
"ade": "theophylline poisoning",
"drug": "theophylline"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A diagnosis of masked theophylline poisoning should be considered in similar situations involving a rapid decrease of insulin requirements.",
"role": "user"
},
{
"content": "[{'ade': 'theophylline poisoning', 'drug': 'theophylline'}]",
"role": "assistant"
}
] |
The authors describe valproate-induced hyperammonemia and mental status changes in an 88-year-old man, the first known reported case in an elderly patient.
|
[
{
"ade": "hyperammonemia",
"drug": "valproate"
},
{
"ade": "mental status changes",
"drug": "valproate"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The authors describe valproate-induced hyperammonemia and mental status changes in an 88-year-old man, the first known reported case in an elderly patient.",
"role": "user"
},
{
"content": "[{'ade': 'hyperammonemia', 'drug': 'valproate'}, {'ade': 'mental status changes', 'drug': 'valproate'}]",
"role": "assistant"
}
] |
We recommend that clinicians monitor patients for signs and symptoms of pancreatitis, including abdominal pain, during treatment with tigecycline.
|
[
{
"ade": "pancreatitis",
"drug": "tigecycline"
},
{
"ade": "abdominal pain",
"drug": "tigecycline"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We recommend that clinicians monitor patients for signs and symptoms of pancreatitis, including abdominal pain, during treatment with tigecycline.",
"role": "user"
},
{
"content": "[{'ade': 'pancreatitis', 'drug': 'tigecycline'}, {'ade': 'abdominal pain', 'drug': 'tigecycline'}]",
"role": "assistant"
}
] |
Two cases of sirolimus-associated pneumonitis have been reported after cardiac transplantation.
|
[
{
"ade": "pneumonitis",
"drug": "sirolimus"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Two cases of sirolimus-associated pneumonitis have been reported after cardiac transplantation.",
"role": "user"
},
{
"content": "[{'ade': 'pneumonitis', 'drug': 'sirolimus'}]",
"role": "assistant"
}
] |
The presence of a lymphocyte alveolitis with a predominance of CD4+ T cells in 3 RA patients and CD8+ T cells with a concomitant increase in neutrophils in another case suggests that immunologically mediated reactions may be one damage mechanism in MTX-induced pneumonitis.
|
[
{
"ade": "pneumonitis",
"drug": "MTX"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The presence of a lymphocyte alveolitis with a predominance of CD4+ T cells in 3 RA patients and CD8+ T cells with a concomitant increase in neutrophils in another case suggests that immunologically mediated reactions may be one damage mechanism in MTX-induced pneumonitis.",
"role": "user"
},
{
"content": "[{'ade': 'pneumonitis', 'drug': 'MTX'}]",
"role": "assistant"
}
] |
While the introduction of carmustine wafers (Gliadel wafers) into the tumor resection cavity has been shown to be a beneficial therapy for malignant glioma, it is recognized that clinically significant cerebral edema is a potential adverse effect.
|
[
{
"ade": "cerebral edema",
"drug": "Gliadel"
},
{
"ade": "cerebral edema",
"drug": "carmustine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: While the introduction of carmustine wafers (Gliadel wafers) into the tumor resection cavity has been shown to be a beneficial therapy for malignant glioma, it is recognized that clinically significant cerebral edema is a potential adverse effect.",
"role": "user"
},
{
"content": "[{'ade': 'cerebral edema', 'drug': 'Gliadel'}, {'ade': 'cerebral edema', 'drug': 'carmustine'}]",
"role": "assistant"
}
] |
The objective of this report is to describe a case of fixed drug eruption that occurred during omeprazole treatment.
|
[
{
"ade": "eruption",
"drug": "omeprazole"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The objective of this report is to describe a case of fixed drug eruption that occurred during omeprazole treatment.",
"role": "user"
},
{
"content": "[{'ade': 'eruption', 'drug': 'omeprazole'}]",
"role": "assistant"
}
] |
Reversal of gold-induced neutropenia with granulocyte colony-stimulating factor (G-CSF).
|
[
{
"ade": "neutropenia",
"drug": "gold"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Reversal of gold-induced neutropenia with granulocyte colony-stimulating factor (G-CSF).",
"role": "user"
},
{
"content": "[{'ade': 'neutropenia', 'drug': 'gold'}]",
"role": "assistant"
}
] |
Ataxia caused by propafenone has been reported to the pharmaceutical companies and drug monitoring agencies, but has not been well described or emphasized in the medical literature.
|
[
{
"ade": "Ataxia",
"drug": "propafenone"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Ataxia caused by propafenone has been reported to the pharmaceutical companies and drug monitoring agencies, but has not been well described or emphasized in the medical literature.",
"role": "user"
},
{
"content": "[{'ade': 'Ataxia', 'drug': 'propafenone'}]",
"role": "assistant"
}
] |
In the presented case fluvoxamine-induced akathisia in an OCD patient was partially resistant to the anticholinergic agent biperiden, and was successfully treated with the 5-HT2A/5-HT2C antagonist mianserin.
|
[
{
"ade": "akathisia",
"drug": "fluvoxamine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: In the presented case fluvoxamine-induced akathisia in an OCD patient was partially resistant to the anticholinergic agent biperiden, and was successfully treated with the 5-HT2A/5-HT2C antagonist mianserin.",
"role": "user"
},
{
"content": "[{'ade': 'akathisia', 'drug': 'fluvoxamine'}]",
"role": "assistant"
}
] |
Epstein-Barr virus-associated lymphoproliferative disorder in a patient with rheumatoid arthritis on methotrexate and rofecoxib: idiosyncratic reaction or pharmacogenetics?
|
[
{
"ade": "Epstein-Barr virus-associated lymphoproliferative disorder",
"drug": "methotrexate"
},
{
"ade": "Epstein-Barr virus-associated lymphoproliferative disorder",
"drug": "rofecoxib"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Epstein-Barr virus-associated lymphoproliferative disorder in a patient with rheumatoid arthritis on methotrexate and rofecoxib: idiosyncratic reaction or pharmacogenetics?",
"role": "user"
},
{
"content": "[{'ade': 'Epstein-Barr virus-associated lymphoproliferative disorder', 'drug': 'methotrexate'}, {'ade': 'Epstein-Barr virus-associated lymphoproliferative disorder', 'drug': 'rofecoxib'}]",
"role": "assistant"
}
] |
Treatment of amiodarone-induced thyrotoxicosis (AIT) with thionamide, lithium or radioactive iodine is ineffective.
|
[
{
"ade": "thyrotoxicosis",
"drug": "amiodarone"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Treatment of amiodarone-induced thyrotoxicosis (AIT) with thionamide, lithium or radioactive iodine is ineffective.",
"role": "user"
},
{
"content": "[{'ade': 'thyrotoxicosis', 'drug': 'amiodarone'}]",
"role": "assistant"
}
] |
Methotrexate-induced diffuse interstitial pulmonary fibrosis.
|
[
{
"ade": "diffuse interstitial pulmonary fibrosis",
"drug": "Methotrexate"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Methotrexate-induced diffuse interstitial pulmonary fibrosis.",
"role": "user"
},
{
"content": "[{'ade': 'diffuse interstitial pulmonary fibrosis', 'drug': 'Methotrexate'}]",
"role": "assistant"
}
] |
Acute myelogenous leukemia in patients receiving chlorambucil as long-term adjuvant chemotherapy for stage II breast cancer.
|
[
{
"ade": "Acute myelogenous leukemia",
"drug": "chlorambucil"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Acute myelogenous leukemia in patients receiving chlorambucil as long-term adjuvant chemotherapy for stage II breast cancer.",
"role": "user"
},
{
"content": "[{'ade': 'Acute myelogenous leukemia', 'drug': 'chlorambucil'}]",
"role": "assistant"
}
] |
However, several case reports have suggested that clozapine could also cause TD.
|
[
{
"ade": "TD",
"drug": "clozapine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: However, several case reports have suggested that clozapine could also cause TD.",
"role": "user"
},
{
"content": "[{'ade': 'TD', 'drug': 'clozapine'}]",
"role": "assistant"
}
] |
Aggressive endometrial carcinoma in a breast cancer patient treated with tamoxifen with normal transvaginal ultrasonography.
|
[
{
"ade": "Aggressive endometrial carcinoma",
"drug": "tamoxifen"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Aggressive endometrial carcinoma in a breast cancer patient treated with tamoxifen with normal transvaginal ultrasonography.",
"role": "user"
},
{
"content": "[{'ade': 'Aggressive endometrial carcinoma', 'drug': 'tamoxifen'}]",
"role": "assistant"
}
] |
A 56-year-old white woman with a diagnosis of reactive depression developed severe UI after a 30 days' treatment with venlafaxine 75 mg/day.
|
[
{
"ade": "UI",
"drug": "venlafaxine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A 56-year-old white woman with a diagnosis of reactive depression developed severe UI after a 30 days' treatment with venlafaxine 75 mg/day.",
"role": "user"
},
{
"content": "[{'ade': 'UI', 'drug': 'venlafaxine'}]",
"role": "assistant"
}
] |
Paradoxical precipitation of tonic seizures by lorazepam in a child with atypical absence seizures.
|
[
{
"ade": "Paradoxical precipitation of tonic seizures",
"drug": "lorazepam"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Paradoxical precipitation of tonic seizures by lorazepam in a child with atypical absence seizures.",
"role": "user"
},
{
"content": "[{'ade': 'Paradoxical precipitation of tonic seizures', 'drug': 'lorazepam'}]",
"role": "assistant"
}
] |
Fatal pulmonary fibrosis associated with BCNU: the relative role of platelet-derived growth factor-B, insulin-like growth factor I, transforming growth factor-beta1 and cyclooxygenase-2.
|
[
{
"ade": "Fatal pulmonary fibrosis",
"drug": "BCNU"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Fatal pulmonary fibrosis associated with BCNU: the relative role of platelet-derived growth factor-B, insulin-like growth factor I, transforming growth factor-beta1 and cyclooxygenase-2.",
"role": "user"
},
{
"content": "[{'ade': 'Fatal pulmonary fibrosis', 'drug': 'BCNU'}]",
"role": "assistant"
}
] |
Uveitis during treatment of disseminated Mycobacterium avium-intracellulare complex infection with the combination of rifabutin, clarithromycin and ethambutol.
|
[
{
"ade": "Uveitis",
"drug": "rifabutin"
},
{
"ade": "Uveitis",
"drug": "ethambutol"
},
{
"ade": "Uveitis",
"drug": "clarithromycin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Uveitis during treatment of disseminated Mycobacterium avium-intracellulare complex infection with the combination of rifabutin, clarithromycin and ethambutol.",
"role": "user"
},
{
"content": "[{'ade': 'Uveitis', 'drug': 'rifabutin'}, {'ade': 'Uveitis', 'drug': 'ethambutol'}, {'ade': 'Uveitis', 'drug': 'clarithromycin'}]",
"role": "assistant"
}
] |
She was thus diagnosed as having AZ intoxication.
|
[
{
"ade": "AZ intoxication",
"drug": "AZ"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: She was thus diagnosed as having AZ intoxication.",
"role": "user"
},
{
"content": "[{'ade': 'AZ intoxication', 'drug': 'AZ'}]",
"role": "assistant"
}
] |
OBJECTIVE: The aim of this paper is to describe a case of increased libido during fluvoxamine therapy.
|
[
{
"ade": "increased libido",
"drug": "fluvoxamine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: OBJECTIVE: The aim of this paper is to describe a case of increased libido during fluvoxamine therapy.",
"role": "user"
},
{
"content": "[{'ade': 'increased libido', 'drug': 'fluvoxamine'}]",
"role": "assistant"
}
] |
In one instance a systemic hypoglycemic reaction resulting in head trauma and confusion ended in an emegency hospital admission following the substitution of acetohexamide for acetazolamide.
|
[
{
"ade": "confusion",
"drug": "acetohexamide"
},
{
"ade": "head trauma",
"drug": "acetohexamide"
},
{
"ade": "systemic hypoglycemic reaction",
"drug": "acetohexamide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: In one instance a systemic hypoglycemic reaction resulting in head trauma and confusion ended in an emegency hospital admission following the substitution of acetohexamide for acetazolamide.",
"role": "user"
},
{
"content": "[{'ade': 'confusion', 'drug': 'acetohexamide'}, {'ade': 'head trauma', 'drug': 'acetohexamide'}, {'ade': 'systemic hypoglycemic reaction', 'drug': 'acetohexamide'}]",
"role": "assistant"
}
] |
Skin necrosis secondary to low-molecular weight heparin in a patient with antiphospholipid antibody syndrome.
|
[
{
"ade": "Skin necrosis",
"drug": "low-molecular weight heparin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Skin necrosis secondary to low-molecular weight heparin in a patient with antiphospholipid antibody syndrome.",
"role": "user"
},
{
"content": "[{'ade': 'Skin necrosis', 'drug': 'low-molecular weight heparin'}]",
"role": "assistant"
}
] |
Drug-induced psychosis resulted from the administration of quinacrine hydrochloride at a dosage of 100 mg twice daily for the treatment of discoid lupus.
|
[
{
"ade": "psychosis",
"drug": "quinacrine hydrochloride"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Drug-induced psychosis resulted from the administration of quinacrine hydrochloride at a dosage of 100 mg twice daily for the treatment of discoid lupus.",
"role": "user"
},
{
"content": "[{'ade': 'psychosis', 'drug': 'quinacrine hydrochloride'}]",
"role": "assistant"
}
] |
We describe a patient who developed acute cerebellar syndrome after prophylactic intrathecal methotrexate administration and recovered spontaneously.
|
[
{
"ade": "acute cerebellar syndrome",
"drug": "methotrexate"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We describe a patient who developed acute cerebellar syndrome after prophylactic intrathecal methotrexate administration and recovered spontaneously.",
"role": "user"
},
{
"content": "[{'ade': 'acute cerebellar syndrome', 'drug': 'methotrexate'}]",
"role": "assistant"
}
] |
We present a case of a 20-year-old woman who ingested 900 mg of glyburide causing refractory hypoglycemia resistant to treatment with intravenous dextrose, glucagon, and diazoxide.
|
[
{
"ade": "hypoglycemia",
"drug": "glyburide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We present a case of a 20-year-old woman who ingested 900 mg of glyburide causing refractory hypoglycemia resistant to treatment with intravenous dextrose, glucagon, and diazoxide.",
"role": "user"
},
{
"content": "[{'ade': 'hypoglycemia', 'drug': 'glyburide'}]",
"role": "assistant"
}
] |
TREATMENT/OUTCOME: Standard anti-tuberculosis therapy was administered but was complicated by interaction with cyclosporine and drug-induced cholestasis.
|
[
{
"ade": "cholestasis",
"drug": "cyclosporine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: TREATMENT/OUTCOME: Standard anti-tuberculosis therapy was administered but was complicated by interaction with cyclosporine and drug-induced cholestasis.",
"role": "user"
},
{
"content": "[{'ade': 'cholestasis', 'drug': 'cyclosporine'}]",
"role": "assistant"
}
] |
We present the management of agranulocytosis and neutropenic sepsis secondary to carbimazole with recombinant human granulocyte colony stimulating factor (G-CSF).
|
[
{
"ade": "neutropenic sepsis",
"drug": "carbimazole"
},
{
"ade": "agranulocytosis",
"drug": "carbimazole"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We present the management of agranulocytosis and neutropenic sepsis secondary to carbimazole with recombinant human granulocyte colony stimulating factor (G-CSF).",
"role": "user"
},
{
"content": "[{'ade': 'neutropenic sepsis', 'drug': 'carbimazole'}, {'ade': 'agranulocytosis', 'drug': 'carbimazole'}]",
"role": "assistant"
}
] |
Captopril is known to be associated with dermatologic, hematologic, and pulmonary adverse effects.
|
[
{
"ade": "dermatologic, hematologic, and pulmonary adverse effects",
"drug": "Captopril"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Captopril is known to be associated with dermatologic, hematologic, and pulmonary adverse effects.",
"role": "user"
},
{
"content": "[{'ade': 'dermatologic, hematologic, and pulmonary adverse effects', 'drug': 'Captopril'}]",
"role": "assistant"
}
] |
Clozapine-induced eosinophilia and switch to quetiapine in a patient with chronic schizophrenia with suicidal tendencies.
|
[
{
"ade": "eosinophilia",
"drug": "Clozapine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Clozapine-induced eosinophilia and switch to quetiapine in a patient with chronic schizophrenia with suicidal tendencies.",
"role": "user"
},
{
"content": "[{'ade': 'eosinophilia', 'drug': 'Clozapine'}]",
"role": "assistant"
}
] |
This report details the pulmonary pathologic findings in four patients with rheumatoid arthritis, who developed new onset of pulmonary signs and symptoms with alveolar infiltrates temporally related to the institution of etanercept therapy.
|
[
{
"ade": "pulmonary signs and symptoms with alveolar infiltrates",
"drug": "etanercept"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: This report details the pulmonary pathologic findings in four patients with rheumatoid arthritis, who developed new onset of pulmonary signs and symptoms with alveolar infiltrates temporally related to the institution of etanercept therapy.",
"role": "user"
},
{
"content": "[{'ade': 'pulmonary signs and symptoms with alveolar infiltrates', 'drug': 'etanercept'}]",
"role": "assistant"
}
] |
This is a rare case of ARDS associated with lithium intoxication.
|
[
{
"ade": "ARDS",
"drug": "lithium"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: This is a rare case of ARDS associated with lithium intoxication.",
"role": "user"
},
{
"content": "[{'ade': 'ARDS', 'drug': 'lithium'}]",
"role": "assistant"
}
] |
Metabolic acidosis induced by acetazolamide.
|
[
{
"ade": "Metabolic acidosis",
"drug": "acetazolamide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Metabolic acidosis induced by acetazolamide.",
"role": "user"
},
{
"content": "[{'ade': 'Metabolic acidosis', 'drug': 'acetazolamide'}]",
"role": "assistant"
}
] |
We report here a case of cardiovascular and neurological depression induced by oxymetalzoline in a toddler.
|
[
{
"ade": "neurological depression",
"drug": "oxymetalzoline"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We report here a case of cardiovascular and neurological depression induced by oxymetalzoline in a toddler.",
"role": "user"
},
{
"content": "[{'ade': 'neurological depression', 'drug': 'oxymetalzoline'}]",
"role": "assistant"
}
] |
It should be recognized that ibuprofen may be associated with salt and water retention in the same fashion as previously described with phenylbutazone and indomethacin.
|
[
{
"ade": "salt and water retention",
"drug": "indomethacin"
},
{
"ade": "salt and water retention",
"drug": "ibuprofen"
},
{
"ade": "salt and water retention",
"drug": "phenylbutazone"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: It should be recognized that ibuprofen may be associated with salt and water retention in the same fashion as previously described with phenylbutazone and indomethacin.",
"role": "user"
},
{
"content": "[{'ade': 'salt and water retention', 'drug': 'indomethacin'}, {'ade': 'salt and water retention', 'drug': 'ibuprofen'}, {'ade': 'salt and water retention', 'drug': 'phenylbutazone'}]",
"role": "assistant"
}
] |
A diagnosis of infliximab-induced lupus was made and the drug treatment was withdrawn.
|
[
{
"ade": "lupus",
"drug": "infliximab"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A diagnosis of infliximab-induced lupus was made and the drug treatment was withdrawn.",
"role": "user"
},
{
"content": "[{'ade': 'lupus', 'drug': 'infliximab'}]",
"role": "assistant"
}
] |
Magnesium tocolysis as the cause of urinary calculus during pregnancy.
|
[
{
"ade": "urinary calculus",
"drug": "Magnesium"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Magnesium tocolysis as the cause of urinary calculus during pregnancy.",
"role": "user"
},
{
"content": "[{'ade': 'urinary calculus', 'drug': 'Magnesium'}]",
"role": "assistant"
}
] |
This is the first case, to our knowledge, of onset of prolonged infliximab-induced lupus.
|
[
{
"ade": "lupus",
"drug": "infliximab"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: This is the first case, to our knowledge, of onset of prolonged infliximab-induced lupus.",
"role": "user"
},
{
"content": "[{'ade': 'lupus', 'drug': 'infliximab'}]",
"role": "assistant"
}
] |
Generalised pustular psoriasis induced by cyclosporin a withdrawal responding to the tumour necrosis factor alpha inhibitor etanercept.
|
[
{
"ade": "Generalised pustular psoriasis",
"drug": "cyclosporin a"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Generalised pustular psoriasis induced by cyclosporin a withdrawal responding to the tumour necrosis factor alpha inhibitor etanercept.",
"role": "user"
},
{
"content": "[{'ade': 'Generalised pustular psoriasis', 'drug': 'cyclosporin a'}]",
"role": "assistant"
}
] |
Extensive immunological investigations were performed in a patient with definite seronegative rheumatoid arthritis who developed hypogammaglobulinemia in the course of gold therapy.
|
[
{
"ade": "hypogammaglobulinemia",
"drug": "gold"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Extensive immunological investigations were performed in a patient with definite seronegative rheumatoid arthritis who developed hypogammaglobulinemia in the course of gold therapy.",
"role": "user"
},
{
"content": "[{'ade': 'hypogammaglobulinemia', 'drug': 'gold'}]",
"role": "assistant"
}
] |
This case supports the assessment that MH and diabetes are associated diseases and that cresol could possibly trigger MH.
|
[
{
"ade": "MH",
"drug": "cresol"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: This case supports the assessment that MH and diabetes are associated diseases and that cresol could possibly trigger MH.",
"role": "user"
},
{
"content": "[{'ade': 'MH', 'drug': 'cresol'}]",
"role": "assistant"
}
] |
Two days after administration of Kalimate enema, he had profuse hematochezia, and a sigmoidoscopy showed diffuse colonic mucosal necrosis in the rectum and sigmoid colon.
|
[
{
"ade": "profuse hematochezia",
"drug": "Kalimate"
},
{
"ade": "colonic mucosal necrosis in the rectum",
"drug": "Kalimate"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Two days after administration of Kalimate enema, he had profuse hematochezia, and a sigmoidoscopy showed diffuse colonic mucosal necrosis in the rectum and sigmoid colon.",
"role": "user"
},
{
"content": "[{'ade': 'profuse hematochezia', 'drug': 'Kalimate'}, {'ade': 'colonic mucosal necrosis in the rectum', 'drug': 'Kalimate'}]",
"role": "assistant"
}
] |
We present an AIDS patient with severe and prolonged lactic acidosis on stavudine and lamivudine.
|
[
{
"ade": "lactic acidosis",
"drug": "stavudine"
},
{
"ade": "lactic acidosis",
"drug": "lamivudine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We present an AIDS patient with severe and prolonged lactic acidosis on stavudine and lamivudine.",
"role": "user"
},
{
"content": "[{'ade': 'lactic acidosis', 'drug': 'stavudine'}, {'ade': 'lactic acidosis', 'drug': 'lamivudine'}]",
"role": "assistant"
}
] |
Our objective is to present a retrospective analysis of the DWI findings in four patients who suffered subacute neurotoxicity after intrathecal MTX.
|
[
{
"ade": "subacute neurotoxicity",
"drug": "MTX"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Our objective is to present a retrospective analysis of the DWI findings in four patients who suffered subacute neurotoxicity after intrathecal MTX.",
"role": "user"
},
{
"content": "[{'ade': 'subacute neurotoxicity', 'drug': 'MTX'}]",
"role": "assistant"
}
] |
We report on three patients who developed acute liver damage during therapy with itraconazole, and in whom liver biopsy specimens were obtained.
|
[
{
"ade": "liver damage",
"drug": "itraconazole"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We report on three patients who developed acute liver damage during therapy with itraconazole, and in whom liver biopsy specimens were obtained.",
"role": "user"
},
{
"content": "[{'ade': 'liver damage', 'drug': 'itraconazole'}]",
"role": "assistant"
}
] |
Insulin-induced lipohypertrophy: report of a case with histopathology.
|
[
{
"ade": "lipohypertrophy",
"drug": "Insulin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Insulin-induced lipohypertrophy: report of a case with histopathology.",
"role": "user"
},
{
"content": "[{'ade': 'lipohypertrophy', 'drug': 'Insulin'}]",
"role": "assistant"
}
] |
Possible mechanisms by which clonidine decreases spasticity are described, probable mechanisms of induced bradycardia are reviewed, and specific treatment recommendations for the use of clonidine in spinal cord injured patients are presented.
|
[
{
"ade": "bradycardia",
"drug": "clonidine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Possible mechanisms by which clonidine decreases spasticity are described, probable mechanisms of induced bradycardia are reviewed, and specific treatment recommendations for the use of clonidine in spinal cord injured patients are presented.",
"role": "user"
},
{
"content": "[{'ade': 'bradycardia', 'drug': 'clonidine'}]",
"role": "assistant"
}
] |
We suggest that objective evaluation of retinal function with electrophysiological methods should be performed in patients with visual disturbance during treatment with rifabutin.
|
[
{
"ade": "visual disturbance",
"drug": "rifabutin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We suggest that objective evaluation of retinal function with electrophysiological methods should be performed in patients with visual disturbance during treatment with rifabutin.",
"role": "user"
},
{
"content": "[{'ade': 'visual disturbance', 'drug': 'rifabutin'}]",
"role": "assistant"
}
] |
Fatal ventricular fibrillation after treatment with digoxin in a 27-year-old man with mitral leaflet prolapse syndrome.
|
[
{
"ade": "Fatal ventricular fibrillation",
"drug": "digoxin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Fatal ventricular fibrillation after treatment with digoxin in a 27-year-old man with mitral leaflet prolapse syndrome.",
"role": "user"
},
{
"content": "[{'ade': 'Fatal ventricular fibrillation', 'drug': 'digoxin'}]",
"role": "assistant"
}
] |
Because psoralens sensitize skin to ultraviolet A light, phototoxic reactions are the most frequent adverse effect of this treatment.
|
[
{
"ade": "phototoxic reactions",
"drug": "psoralens"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Because psoralens sensitize skin to ultraviolet A light, phototoxic reactions are the most frequent adverse effect of this treatment.",
"role": "user"
},
{
"content": "[{'ade': 'phototoxic reactions', 'drug': 'psoralens'}]",
"role": "assistant"
}
] |
Severe cardiomyopathy following treatment with the tumour necrosis factor-alpha inhibitor adalimumab for Crohn's disease.
|
[
{
"ade": "Severe cardiomyopathy",
"drug": "adalimumab"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Severe cardiomyopathy following treatment with the tumour necrosis factor-alpha inhibitor adalimumab for Crohn's disease.",
"role": "user"
},
{
"content": "[{'ade': 'Severe cardiomyopathy', 'drug': 'adalimumab'}]",
"role": "assistant"
}
] |
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