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text stringlengths 22 455	relations listlengths 1 24	messages listlengths 2 2
Etoposide-related myocardial infarction.	[ { "ade": "myocardial infarction", "drug": "Etoposide" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Etoposide-related myocardial infarction.", "role": "user" }, { "content": "[{'ade': 'myocardial infarction', 'drug': 'E...
Case studies in heparin-induced thrombocytopenia.	[ { "ade": "thrombocytopenia", "drug": "heparin" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Case studies in heparin-induced thrombocytopenia.", "role": "user" }, { "content": "[{'ade': 'thrombocytopenia', 'drug'...
We report the first case of chlorambucil-induced DRESS syndrome in a 70-year-old man recently diagnosed with chronic lymphocytic leukaemia.	[ { "ade": "DRESS syndrome", "drug": "chlorambucil" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We report the first case of chlorambucil-induced DRESS syndrome in a 70-year-old man recently diagnosed with chronic lymphocytic le...
The cases of CBZ-induced SLE reported in the literature were reviewed.	[ { "ade": "SLE", "drug": "CBZ" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The cases of CBZ-induced SLE reported in the literature were reviewed.", "role": "user" }, { "content": "[{'ade': 'SLE'...
The increasing prevalence of methamphetamine abuse and the severity of the associated ulcers should alert ophthalmologists to the problem of methamphetamine-related keratitis.	[ { "ade": "keratitis", "drug": "methamphetamine" }, { "ade": "ulcers", "drug": "methamphetamine" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The increasing prevalence of methamphetamine abuse and the severity of the associated ulcers should alert ophthalmologists to the p...
Linezolid-induced dyserythropoiesis: chloramphenicol toxicity revisited.	[ { "ade": "dyserythropoiesis", "drug": "Linezolid" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Linezolid-induced dyserythropoiesis: chloramphenicol toxicity revisited.", "role": "user" }, { "content": "[{'ade': 'dy...
Methemoglobinemia: an occupational hazard of phenylpropanolamine production.	[ { "ade": "Methemoglobinemia", "drug": "phenylpropanolamine" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Methemoglobinemia: an occupational hazard of phenylpropanolamine production.", "role": "user" }, { "content": "[{'ade':...
Bilateral acoustic (VIII) nerve palsy in this patient was most likely a manifestation of vincristine neurotoxicity.	[ { "ade": "neurotoxicity", "drug": "vincristine" }, { "ade": "Bilateral acoustic (VIII) nerve palsy", "drug": "vincristine" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Bilateral acoustic (VIII) nerve palsy in this patient was most likely a manifestation of vincristine neurotoxicity.", "role": "...
Tumor lysis syndrome after transcatheter arterial infusion of cisplatin and embolization therapy for liver metastases of melanoma.	[ { "ade": "Tumor lysis syndrome", "drug": "cisplatin" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Tumor lysis syndrome after transcatheter arterial infusion of cisplatin and embolization therapy for liver metastases of melanoma."...
Acute renal failure with severe tubulointerstitial changes in a patient with minimal change nephrotic syndrome treated with enalapril.	[ { "ade": "severe tubulointerstitial changes", "drug": "enalapril" }, { "ade": "Acute renal failure", "drug": "enalapril" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Acute renal failure with severe tubulointerstitial changes in a patient with minimal change nephrotic syndrome treated with enalapr...
Ibopamine-induced reversible leukopenia during treatment for congestive heart failure.	[ { "ade": "leukopenia", "drug": "Ibopamine" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Ibopamine-induced reversible leukopenia during treatment for congestive heart failure.", "role": "user" }, { "content":...
NMS is a drug-related response to various medications, such as Haloperidol, which the patient was receiving.	[ { "ade": "NMS", "drug": "Haloperidol" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: NMS is a drug-related response to various medications, such as Haloperidol, which the patient was receiving.", "role": "user" ...
We describe 2 patients with severe erosive rheumatoid arthritis and rheumatoid vasculitis, respectively, in whom infliximab therapy was associated with peripheral neuropathy due to necrotizing vasculitis in one patient and to progression of preexisting mononeuritis multiplex in the other.	[ { "ade": "necrotizing vasculitis", "drug": "infliximab" }, { "ade": "peripheral neuropathy", "drug": "infliximab" }, { "ade": "progression of preexisting mononeuritis multiplex", "drug": "infliximab" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We describe 2 patients with severe erosive rheumatoid arthritis and rheumatoid vasculitis, respectively, in whom infliximab therapy...
She developed neurotoxicity with an adjustment dosage of valacyclovir for a cutaneous zoster infection.	[ { "ade": "neurotoxicity", "drug": "valacyclovir" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: She developed neurotoxicity with an adjustment dosage of valacyclovir for a cutaneous zoster infection.", "role": "user" }, ...
CONCLUSION: Anterior ischemic optic neuropathy may complicate treatment with interferon alfa.	[ { "ade": "Anterior ischemic optic neuropathy", "drug": "interferon alfa" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: CONCLUSION: Anterior ischemic optic neuropathy may complicate treatment with interferon alfa.", "role": "user" }, { "co...
Increased libido in a woman treated with fluvoxamine: a case report.	[ { "ade": "Increased libido", "drug": "fluvoxamine" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Increased libido in a woman treated with fluvoxamine: a case report.", "role": "user" }, { "content": "[{'ade': 'Increa...
To our knowledge, no prior cases of penicillamine-induced TTP in RA have been reported.	[ { "ade": "TTP", "drug": "penicillamine" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: To our knowledge, no prior cases of penicillamine-induced TTP in RA have been reported.", "role": "user" }, { "content"...
Vancomycin is the most frequently implicated drug, but other agents have been reported to cause LABD.	[ { "ade": "LABD", "drug": "Vancomycin" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Vancomycin is the most frequently implicated drug, but other agents have been reported to cause LABD.", "role": "user" }, {...
The patient was initially treated with hydration and furosemide but developed congestive heart failure.	[ { "ade": "congestive heart failure", "drug": "furosemide" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The patient was initially treated with hydration and furosemide but developed congestive heart failure.", "role": "user" }, ...
We report a case of hypoglycaemia after mefloquine therapy (1,500 mg over two days) for severe gastrointestinal cryptosporidiasis in a cachectic AIDS patient with protracted diarrhoea.	[ { "ade": "hypoglycaemia", "drug": "mefloquine" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We report a case of hypoglycaemia after mefloquine therapy (1,500 mg over two days) for severe gastrointestinal cryptosporidiasis i...
The most common side effects associated with amifostine are nausea, vomiting, hypotension, hypocalcemia and allergic reactions.	[ { "ade": "nausea", "drug": "amifostine" }, { "ade": "hypocalcemia", "drug": "amifostine" }, { "ade": "vomiting", "drug": "amifostine" }, { "ade": "allergic reactions", "drug": "amifostine" }, { "ade": "hypotension", "drug": "amifostine" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The most common side effects associated with amifostine are nausea, vomiting, hypotension, hypocalcemia and allergic reactions.", ...
In 2 of the 3 cases the patients were also taking lithium carbonate and beta-blockers, both of which could have contributed to the incontinence.	[ { "ade": "incontinence", "drug": "lithium carbonate" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: In 2 of the 3 cases the patients were also taking lithium carbonate and beta-blockers, both of which could have contributed to the ...
This report suggests that bleomycin lung toxicity may be reversible if treated aggressively.	[ { "ade": "lung toxicity", "drug": "bleomycin" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: This report suggests that bleomycin lung toxicity may be reversible if treated aggressively.", "role": "user" }, { "con...
The events of non-convulsive status epilepticus subsided following reduction in tiagabine dosages.	[ { "ade": "non-convulsive status epilepticus", "drug": "tiagabine" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The events of non-convulsive status epilepticus subsided following reduction in tiagabine dosages.", "role": "user" }, { ...
The case of a 4-year-old girl with valproate-induced stupor and electroencephalographic pattern of increased fast activity is reported.	[ { "ade": "stupor", "drug": "valproate" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The case of a 4-year-old girl with valproate-induced stupor and electroencephalographic pattern of increased fast activity is repor...
Loperamide poisoning in the dog.	[ { "ade": "Loperamide poisoning", "drug": "Loperamide" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Loperamide poisoning in the dog.", "role": "user" }, { "content": "[{'ade': 'Loperamide poisoning', 'drug': 'Loperamide...
A 22-year-old drug-abuser injected flunitrazepam tablets dissolved in tap water into her left femoral artery and presented with clinical signs of acute ischaemia of the left leg.	[ { "ade": "acute ischaemia of the left leg", "drug": "flunitrazepam" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A 22-year-old drug-abuser injected flunitrazepam tablets dissolved in tap water into her left femoral artery and presented with cli...
Probable propafenone-induced transient global amnesia.	[ { "ade": "transient global amnesia", "drug": "propafenone" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Probable propafenone-induced transient global amnesia.", "role": "user" }, { "content": "[{'ade': 'transient global amn...
This case represents the third example of erythroid aplasia associated with an anti-inflammatory agent and the first instance due to fenoprofen.	[ { "ade": "erythroid aplasia", "drug": "fenoprofen" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: This case represents the third example of erythroid aplasia associated with an anti-inflammatory agent and the first instance due t...
CONCLUSIONS: The value of multihormonal therapy in breast carcinoma is not established, and the addition of progestogens to tamoxifen may not reduce of developing endometrial lesions, including carcinoma.	[ { "ade": "carcinoma", "drug": "tamoxifen" }, { "ade": "endometrial lesions", "drug": "tamoxifen" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: CONCLUSIONS: The value of multihormonal therapy in breast carcinoma is not established, and the addition of progestogens to tamoxif...
Hypokalemia after normal doses of neubulized albuterol (salbutamol).	[ { "ade": "Hypokalemia", "drug": "salbutamol" }, { "ade": "Hypokalemia", "drug": "albuterol" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Hypokalemia after normal doses of neubulized albuterol (salbutamol).", "role": "user" }, { "content": "[{'ade': 'Hypoka...
We report the case of a 43-year-old man with ITP refractory to steroids and intravenous immunoglobulin who developed acute respiratory distress syndrome (ARDS) after a single infusion of rituximab.	[ { "ade": "acute respiratory distress syndrome", "drug": "rituximab" }, { "ade": "ARDS", "drug": "rituximab" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We report the case of a 43-year-old man with ITP refractory to steroids and intravenous immunoglobulin who developed acute respirat...
It is concluded that SIADH is an important side effect of lorcainide therapy.	[ { "ade": "SIADH", "drug": "lorcainide" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: It is concluded that SIADH is an important side effect of lorcainide therapy.", "role": "user" }, { "content": "[{'ade'...
In summary, we report herein the first case of SIADH believed to be an adverse effect of mizoribin, which may therefore needed to be added to the list of drugs which can induce SIADH.	[ { "ade": "SIADH", "drug": "mizoribin" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: In summary, we report herein the first case of SIADH believed to be an adverse effect of mizoribin, which may therefore needed to b...
The patient whose case is reviewed had migraine headaches and received methysergide maleate for 13 years.	[ { "ade": "migraine headaches", "drug": "methysergide" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The patient whose case is reviewed had migraine headaches and received methysergide maleate for 13 years.", "role": "user" },...
Exacerbation of schizophrenia associated with amantadine.	[ { "ade": "schizophrenia", "drug": "amantadine" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Exacerbation of schizophrenia associated with amantadine.", "role": "user" }, { "content": "[{'ade': 'schizophrenia', '...
Disulfiram-induced hepatitis.	[ { "ade": "hepatitis", "drug": "Disulfiram" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Disulfiram-induced hepatitis.", "role": "user" }, { "content": "[{'ade': 'hepatitis', 'drug': 'Disulfiram'}]", "rol...
It is tempting to speculate that interferon alpha may be involved in the pathogenesis of lichen nitidus.	[ { "ade": "lichen nitidus", "drug": "interferon alpha" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: It is tempting to speculate that interferon alpha may be involved in the pathogenesis of lichen nitidus.", "role": "user" }, ...
Our cases constitute the most severe cases of benzarone hepatotoxicity reported so far, and comprise the first cases of (sub)fulminant hepatitis and cirrhosis related to benzarone.	[ { "ade": "hepatotoxicity", "drug": "benzarone" }, { "ade": "cirrhosis", "drug": "benzarone" }, { "ade": "(sub)fulminant hepatitis", "drug": "benzarone" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Our cases constitute the most severe cases of benzarone hepatotoxicity reported so far, and comprise the first cases of (sub)fulmin...
CONCLUSION: Atovaquone should be added to the list of agents causing vortex keratopathy involving the corneal epithelium.	[ { "ade": "vortex keratopathy", "drug": "Atovaquone" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: CONCLUSION: Atovaquone should be added to the list of agents causing vortex keratopathy involving the corneal epithelium.", "ro...