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The male patient was treated with 225-mg/day clozapine and the time to the diagnosis of agranulocytosis was 6 weeks.	[ { "ade": "agranulocytosis", "drug": "clozapine" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The male patient was treated with 225-mg/day clozapine and the time to the diagnosis of agranulocytosis was 6 weeks.", "role": ...
The clinical course suggests that the interstitial pneumonitis was induced by hydroxyurea.	[ { "ade": "interstitial pneumonitis", "drug": "hydroxyurea" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The clinical course suggests that the interstitial pneumonitis was induced by hydroxyurea.", "role": "user" }, { "conte...
Severe hepatocellular dysfunction following cyproterone acetate therapy.	[ { "ade": "Severe hepatocellular dysfunction", "drug": "cyproterone acetate" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Severe hepatocellular dysfunction following cyproterone acetate therapy.", "role": "user" }, { "content": "[{'ade': 'Se...
BACKGROUND: Hypersensitivity reactions to cyclosporine are rare.	[ { "ade": "Hypersensitivity reactions", "drug": "cyclosporine" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: BACKGROUND: Hypersensitivity reactions to cyclosporine are rare.", "role": "user" }, { "content": "[{'ade': 'Hypersensi...
Statin-associated myasthenia gravis: report of 4 cases and review of the literature.	[ { "ade": "myasthenia gravis", "drug": "Statin" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Statin-associated myasthenia gravis: report of 4 cases and review of the literature.", "role": "user" }, { "content": "...
Cefuroxime-induced acute renal failure.	[ { "ade": "acute renal failure", "drug": "Cefuroxime" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Cefuroxime-induced acute renal failure.", "role": "user" }, { "content": "[{'ade': 'acute renal failure', 'drug': 'Cefu...
A patient with Parkinson's disease, initially treated with bromocriptine and subsequently with cabergoline, developed progressive pleuropulmonary abnormalities during the latter therapy.	[ { "ade": "pleuropulmonary abnormalities", "drug": "bromocriptine" }, { "ade": "pleuropulmonary abnormalities", "drug": "cabergoline" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A patient with Parkinson's disease, initially treated with bromocriptine and subsequently with cabergoline, developed progressive p...
On the fifth day of tocolysis with magnesium sulfate, nifedipine, terbutaline and betamethasone, edema developed in both labia.	[ { "ade": "edema", "drug": "magnesium sulfate" }, { "ade": "edema", "drug": "terbutaline" }, { "ade": "edema", "drug": "nifedipine" }, { "ade": "edema", "drug": "betamethasone" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: On the fifth day of tocolysis with magnesium sulfate, nifedipine, terbutaline and betamethasone, edema developed in both labia.", ...
To our knowledge this is the first report that demonstrates histological abnormalities of the glomerulus associated with postoperative IFN-beta therapy for the malignant melanoma.	[ { "ade": "histological abnormalities of the glomerulus", "drug": "IFN-beta" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: To our knowledge this is the first report that demonstrates histological abnormalities of the glomerulus associated with postoperat...
CONCLUSION: The results suggest that olanzapine may be useful in treating patients with clozapine-induced granulocytopenia without the risk of recurrence of hematologic side effects.	[ { "ade": "granulocytopenia", "drug": "clozapine" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: CONCLUSION: The results suggest that olanzapine may be useful in treating patients with clozapine-induced granulocytopenia without ...
Beneficial effect of low-dose mianserin on fluvoxamine-induced akathisia in an obsessive-compulsive patient.	[ { "ade": "akathisia", "drug": "fluvoxamine" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Beneficial effect of low-dose mianserin on fluvoxamine-induced akathisia in an obsessive-compulsive patient.", "role": "user" ...
Allergic contact angioedema to benzoyl peroxide.	[ { "ade": "Allergic contact angioedema", "drug": "benzoyl peroxide" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Allergic contact angioedema to benzoyl peroxide.", "role": "user" }, { "content": "[{'ade': 'Allergic contact angioedem...
To our knowledge, this recurrence of amiodarone pulmonary toxicity has not been reported previously.	[ { "ade": "pulmonary toxicity", "drug": "amiodarone" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: To our knowledge, this recurrence of amiodarone pulmonary toxicity has not been reported previously.", "role": "user" }, { ...
Interferon-alpha (IFN-alpha) may precipitate or exacerbate the occurrence of MPGN.	[ { "ade": "MPGN", "drug": "Interferon-alpha" }, { "ade": "MPGN", "drug": "IFN-alpha" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Interferon-alpha (IFN-alpha) may precipitate or exacerbate the occurrence of MPGN.", "role": "user" }, { "content": "[{...
Ulcerating enteritis associated with flucytosine therapy.	[ { "ade": "Ulcerating enteritis", "drug": "flucytosine" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Ulcerating enteritis associated with flucytosine therapy.", "role": "user" }, { "content": "[{'ade': 'Ulcerating enteri...
We describe a patient who developed granulocytopenia and fever after taking dipyrone and discuss the available literature.	[ { "ade": "granulocytopenia", "drug": "dipyrone" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We describe a patient who developed granulocytopenia and fever after taking dipyrone and discuss the available literature.", "r...
We report a 13 year-old male who developed life-threatening anaphylaxis early in the course of Increlex therapy.	[ { "ade": "anaphylaxis", "drug": "Increlex" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We report a 13 year-old male who developed life-threatening anaphylaxis early in the course of Increlex therapy.", "role": "use...
Listeria brain abscess, Pneumocystis pneumonia and Kaposi's sarcoma after temozolomide.	[ { "ade": "Pneumocystis pneumonia", "drug": "temozolomide" }, { "ade": "Listeria brain abscess", "drug": "temozolomide" }, { "ade": "Kaposi's sarcoma", "drug": "temozolomide" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Listeria brain abscess, Pneumocystis pneumonia and Kaposi's sarcoma after temozolomide.", "role": "user" }, { "content"...
Thus, tardive seizures in our cases are thought to be related to piperacillin and cefotiam.	[ { "ade": "tardive seizures", "drug": "piperacillin" }, { "ade": "tardive seizures", "drug": "cefotiam" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Thus, tardive seizures in our cases are thought to be related to piperacillin and cefotiam.", "role": "user" }, { "cont...
The most commonly recognized toxic effect of ethambutol is optic neuropathy, which generally is considered uncommon and reversible in medical literature.	[ { "ade": "optic neuropathy", "drug": "ethambutol" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The most commonly recognized toxic effect of ethambutol is optic neuropathy, which generally is considered uncommon and reversible ...
Lymphoma developing in a patient with rheumatoid arthritis taking methotrexate.	[ { "ade": "Lymphoma", "drug": "methotrexate" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Lymphoma developing in a patient with rheumatoid arthritis taking methotrexate.", "role": "user" }, { "content": "[{'ad...
Inadvertent subsequent rechallenge with celiprolol led to recurrence of the pneumonitis, 10 weeks after drug readministration.	[ { "ade": "pneumonitis", "drug": "celiprolol" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Inadvertent subsequent rechallenge with celiprolol led to recurrence of the pneumonitis, 10 weeks after drug readministration.", ...
Development of persistent late onset asthma following treatment with captopril.	[ { "ade": "persistent late onset asthma", "drug": "captopril" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Development of persistent late onset asthma following treatment with captopril.", "role": "user" }, { "content": "[{'ad...
Minor electrocardiographical changes were noted in five out of six patients who were not receiving a cardiac glycoside and four out of six who were receiving ouabain, and none of the 16 who were receiving digoxin.	[ { "ade": "Minor electrocardiographical changes", "drug": "ouabain" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Minor electrocardiographical changes were noted in five out of six patients who were not receiving a cardiac glycoside and four out...
Cutaneous sarcoidosis during interferon alfa and ribavirin treatment of hepatitis C virus infection: two cases.	[ { "ade": "Cutaneous sarcoidosis", "drug": "ribavirin" }, { "ade": "Cutaneous sarcoidosis", "drug": "interferon alfa" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Cutaneous sarcoidosis during interferon alfa and ribavirin treatment of hepatitis C virus infection: two cases.", "role": "user...
This progressed to tracheal compression with stridor after he had taken some aspirin for relief of the neck pain.	[ { "ade": "tracheal compression", "drug": "aspirin" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: This progressed to tracheal compression with stridor after he had taken some aspirin for relief of the neck pain.", "role": "us...
Drug-induced hepatitis in an acromegalic patient during combined treatment with pegvisomant and octreotide long-acting repeatable attributed to the use of pegvisomant.	[ { "ade": "hepatitis", "drug": "pegvisomant" }, { "ade": "hepatitis", "drug": "octreotide" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Drug-induced hepatitis in an acromegalic patient during combined treatment with pegvisomant and octreotide long-acting repeatable a...
She had just finished a 3-week course of intravenous tobramycin for bronchiectasis and had an elevated serum tobramycin trough level 1 week before the onset of tetany.	[ { "ade": "tetany", "drug": "tobramycin" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: She had just finished a 3-week course of intravenous tobramycin for bronchiectasis and had an elevated serum tobramycin trough leve...
Cerebrovascular complications of L-asparaginase therapy in children with leukemia: aphasia and other neuropsychological deficits.	[ { "ade": "Cerebrovascular complications", "drug": "L-asparaginase" }, { "ade": "neuropsychological deficits", "drug": "L-asparaginase" }, { "ade": "aphasia", "drug": "L-asparaginase" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Cerebrovascular complications of L-asparaginase therapy in children with leukemia: aphasia and other neuropsychological deficits.",...
ARA-C is frequently associated with dermatologic toxicity, but this is only the second case of toxic epidermal necrolysis described in connection with this drug.	[ { "ade": "dermatologic toxicity", "drug": "ARA-C" }, { "ade": "toxic epidermal necrolysis", "drug": "ARA-C" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: ARA-C is frequently associated with dermatologic toxicity, but this is only the second case of toxic epidermal necrolysis described...
MI related to the use of activated and non-activated PCCs predominantly affects young patients who often have no preceding history of, or risk factors for, MI and tends to be associated with large cumulative doses of concentrate.	[ { "ade": "MI", "drug": "PCCs" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: MI related to the use of activated and non-activated PCCs predominantly affects young patients who often have no preceding history ...
Mechanism of topiramate-induced acute-onset myopia and angle closure glaucoma.	[ { "ade": "angle closure glaucoma", "drug": "topiramate" }, { "ade": "acute-onset myopia", "drug": "topiramate" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Mechanism of topiramate-induced acute-onset myopia and angle closure glaucoma.", "role": "user" }, { "content": "[{'ade...
Edema associated with ibuprofen therapy.	[ { "ade": "Edema", "drug": "ibuprofen" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Edema associated with ibuprofen therapy.", "role": "user" }, { "content": "[{'ade': 'Edema', 'drug': 'ibuprofen'}]", ...
Rapidly developing hyperglycemia during treatment with olanzapine.	[ { "ade": "hyperglycemia", "drug": "olanzapine" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Rapidly developing hyperglycemia during treatment with olanzapine.", "role": "user" }, { "content": "[{'ade': 'hypergly...
Tacrolimus-induced HUS: an unusual cause of acute renal failure in nephrotic syndrome.	[ { "ade": "acute renal failure", "drug": "Tacrolimus" }, { "ade": "HUS", "drug": "Tacrolimus" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Tacrolimus-induced HUS: an unusual cause of acute renal failure in nephrotic syndrome.", "role": "user" }, { "content":...
Relapse in the external auditory canal of acute promyelocytic leukemia after treatment with all-trans retinoic acid.	[ { "ade": "Relapse in the external auditory canal of acute promyelocytic leukemia", "drug": "all-trans retinoic acid" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Relapse in the external auditory canal of acute promyelocytic leukemia after treatment with all-trans retinoic acid.", "role": ...
Protamine-induced fatal anaphylaxis.	[ { "ade": "fatal anaphylaxis", "drug": "Protamine" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Protamine-induced fatal anaphylaxis.", "role": "user" }, { "content": "[{'ade': 'fatal anaphylaxis', 'drug': 'Protamine...
Our findings suggest that hyperkalemia can develop with the use of low-dose heparin, within seven days of initiating heparin therapy, and that patients with diabetes mellitus or chronic renal insufficiency are especially predisposed to this complication.	[ { "ade": "hyperkalemia", "drug": "heparin" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Our findings suggest that hyperkalemia can develop with the use of low-dose heparin, within seven days of initiating heparin therap...
The noted increase in the theophylline level after zafirlukast administration is in contrast to the original reports by the manufacturer.	[ { "ade": "increase in the theophylline level", "drug": "zafirlukast" }, { "ade": "increase in the theophylline level", "drug": "theophylline" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The noted increase in the theophylline level after zafirlukast administration is in contrast to the original reports by the manufac...
To the best of our knowledge, corneoscleral melting in the first postoperative week after a single intraoperative application of mitomycin C has not been reported.	[ { "ade": "corneoscleral melting", "drug": "mitomycin C" } ]	[ { "content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: To the best of our knowledge, corneoscleral melting in the first postoperative week after a single intraoperative application of mi...