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35,131,864
CD8[+]PD-1[+] to CD4[+]PD-1[+] ratio (PERLS) is associated with prognosis of patients with advanced NSCLC treated with PD-(L)1 blockers.
Journal for immunotherapy of cancer
J Immunother Cancer
10
2
10.1136/jitc-2021-004012
eng
2,022
2
null
null
null
null
[BACKGROUND] Programmed cell death protein-1 (PD-1) expression has been associated with activation and exhaustion of both the CD4 and CD8 populations in advanced non-small cell lung cancer (aNSCLC). Nevertheless, the impact of the balance between circulating CD8[+]PD-1[+] and CD4[+]PD-1[+] in patients treated with immu...
CD4-CD8 ratio; biomarkers; immunotherapy; lung neoplasms; tumor
3.403
136
Cancer Research; Immunology; Immunology and Allergy; Molecular Medicine; Oncology; Pharmacology
Biochemistry, Genetics and Molecular Biology; Immunology and Microbiology; Medicine; Pharmacology, Toxicology and Pharmaceutics
2,022
35,131,508
A practical laboratory method to determine ceftazidime-avibactam-aztreonam synergy in patients with New Delhi metallo-beta-lactamase (NDM)-producing Enterobacterales infection.
Journal of global antimicrobial resistance
J Glob Antimicrob Resist
29
null
10.1016/j.jgar.2022.01.025
eng
2,022
6
null
2,022
2
4
[OBJECTIVES] In response to infection with New Delhi metallo-beta-lactamase (NDM)-producing Enterobacterales, combination antimicrobial therapy with ceftazidime/avibactam (CAZ/AVI) plus aztreonam (ATM) has been explored. This study evaluated a practical laboratory method of testing for clinically significant synergy be...
Aztreonam; Ceftazidime-avibactam; Combination treatment; New Delhi metallo-beta-lactamase; Synergy
0.879
55
Immunology; Immunology and Allergy; Microbiology; Microbiology
Immunology and Microbiology; Medicine
2,022
35,131,375
Common variants in genes involved in islet amyloid polypeptide (IAPP) processing and the degradation pathway are associated with T2DM risk: A Chinese population study.
Diabetes research and clinical practice
Diabetes Res Clin Pract
185
null
10.1016/j.diabres.2022.109235
eng
2,022
3
null
2,022
2
5
[AIM] To explore the genetic effects of SLC30A8, IAPP, PCSK1, PCSK2, CPE, PAM and IDE, key genes involved in IAPP processing and degradation pathway on T2DM risk and metabolic traits in Chinese population. [METHODS] Common variants were genotyped in 10936 Chinese subjects by Asian Screening Array and Multi-Ethnic Globa...
GRS; Genetic risk score; IAPP; Islet amyloid polypeptide; T2DM; Type 2 diabetes mellitus
1.634
146
Endocrinology; Endocrinology, Diabetes and Metabolism; Internal Medicine; Medicine
Biochemistry, Genetics and Molecular Biology; Medicine
2,022
35,130,981
Cluster analysis of personality traits in psychiatric patients with borderline personality disorder.
Borderline personality disorder and emotion dysregulation
Borderline Personal Disord Emot Dysregul
9
1
10.1186/s40479-022-00178-w
eng
2,022
2
8
2,022
2
8
[BACKGROUND] Though the heterogeneous expression of symptoms of borderline personality disorder (BPD) is well-known, it is far from fully understood. Hybrid models combining dimensional and categorical ways of diagnosing BPD have been suggested to better handle this heterogeneity, but more research is needed. The aim o...
Alternative model for personality disorders (AMPD); Borderline personality disorder; Cluster analysis; Endophenotypes; ICD-11; Personality traits; Subtypes; Swedish universities scales of personality (SSP)
1.394
37
Clinical Psychology; Psychiatry and Mental Health; Biological Psychiatry
Medicine; Neuroscience; Psychology
2,022
35,130,910
Neuroprotective effects of alisol A 24-acetate on cerebral ischaemia-reperfusion injury are mediated by regulating the PI3K/AKT pathway.
Journal of neuroinflammation
J Neuroinflammation
19
1
10.1186/s12974-022-02392-3
eng
2,022
2
7
2,022
2
7
[BACKGROUND] Neuroinflammation and apoptosis are involved in the pathogenesis of ischaemic stroke. Alisol A 24-acetate (24A) exerts a strong inhibitory effect on inflammation and cell apoptosis. The neuroprotective effect of 24A on global cerebral ischaemia/reperfusion (GCI/R) injury remains unclear. [METHODS] GCI/R mi...
Alisol A 24-acetate; Apoptosis; GCI/R; PI3K/AKT; inflammation
2.439
168
Cellular and Molecular Neuroscience; Immunology; Neurology; Neuroscience
Immunology and Microbiology; Neuroscience
2,022
35,130,874
Novel detection of mutation in the TECPR2 gene in a Chinese hereditary spastic paraplegia 49 patient: a case report.
BMC neurology
BMC Neurol
22
1
10.1186/s12883-022-02572-x
eng
2,022
2
7
2,022
2
7
[BACKGROUND] Hereditary spastic paraplegia 49 (HSP49) is an autosomal recessive genetic disease first discovered in 2012; and which the mutation primarily affects Bukharian Jewish patients. [CASE PRESENTATION] The present case reports the first instance of HSP49 detected in China. The patient had normal mental developm...
Autosomal recessive inherited disease; Case report; Hereditary spastic paraplegia; Heterozygous mutations; Spastic ataxia
0.771
100
Medicine; Neurology
Medicine
2,022
35,130,851
A new variant of Abernethy malformation treated by transhepatic interventional closure: a case report.
BMC gastroenterology
BMC Gastroenterol
22
1
10.1186/s12876-022-02123-1
eng
2,022
2
7
2,022
2
7
[BACKGROUND] Congenital portosystemic shunts (CPSS) are rare vascular malformations and can be classified into extrahepatic and intrahepatic shunts. Extrahepatic CPSS, also termed Abernethy malformations are associated with severe long-term complications including portopulmonary hypertension, liver atrophy, hyperammoni...
Abernethy malformation; CPSS; Congenital portosystemic shunts; Pulmonary hypertension; Transhepatic closure
0.759
99
Gastroenterology; Medicine
Medicine
2,022
35,130,836
Patient-reported outcomes, health-related quality of life, and acute medication use in patients with a ≥ 75% response to eptinezumab: subgroup pooled analysis of the PROMISE trials.
The journal of headache and pain
J Headache Pain
23
1
10.1186/s10194-022-01386-z
eng
2,022
2
7
2,022
2
7
[BACKGROUND] PROMISE-1 and PROMISE-2 evaluated the preventive efficacy, tolerability, and safety of eptinezumab, a calcitonin gene-related peptide-targeted monoclonal antibody, in adults with episodic (EM) and chronic migraine (CM), finding significant reductions in migraine frequency. This post hoc analysis compared p...
CGRP monoclonal antibody; Eptinezumab; Responder analysis
1.593
97
Anesthesiology and Pain Medicine; Medicine; Neurology
Medicine
2,022
35,130,348
Dental arch changes after anterior open bite treatment in the mixed dentition produced by miniscrew-supported palatal crib vs conventional fixed palatal crib.
The Angle orthodontist
Angle Orthod
92
4
10.2319/082321-659.1
eng
2,022
7
1
null
null
null
[OBJECTIVES] To evaluate the dental arch changes produced by the miniscrew-supported palatal crib (MSPC) and the conventional fixed palatal crib (CFPC) after the treatment of patients with anterior open bite (AOB) attributed to the tongue-thrusting habit in the mixed dentition stage. [MATERIALS AND METHODS] A total of ...
Digital models; Early treatment; Miniscrews; Open bite; Palatal crib
1.167
113
Medicine; Orthodontics
Dentistry; Medicine
2,022
35,130,224
The role of Aescin versus Prednisolone in the management of symptomatic lower ureteral calculi: A comparative study.
JPMA. The Journal of the Pakistan Medical Association
J Pak Med Assoc
71(Suppl 8)
12
null
eng
2,021
12
null
null
null
null
[OBJECTIVE] To evaluate the efficacy and safety of aescin compared to prednisolone in the management of symptomatic distal ureteral stones. [METHODS] The prospective comparative study was conducted from April 2016 to December 2019 at Al-Yarmouk teaching hospital, Baghdad after approval from the Iraqi Board of Urology a...
null
null
null
null
null
null
35,129,733
Enhanced-view totally extraperitoneal repair in a patient with incisional hernia after robot-assisted laparoscopic radical prostatectomy: a case report.
Surgical case reports
Surg Case Rep
8
1
10.1186/s40792-022-01380-2
eng
2,022
2
7
2,022
2
7
[BACKGROUND] Although laparoscopic incisional hernia repair, especially laparoscopic intraperitoneal onlay mesh, is a widely used technique, it can cause serious complications, including mesh erosion, adhesive bowel obstruction, and chronic pain. The enhanced-view totally extraperitoneal (eTEP) technique has been repor...
Incisional hernia; RARP; Ventral hernia; eTEP
null
null
null
null
null
35,129,727
Response to neoadjuvant chemotherapy and survival in molecular subtypes of resectable gastric cancer: a post hoc analysis of the D1/D2 and CRITICS trials.
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association
Gastric Cancer
25
3
10.1007/s10120-022-01280-2
eng
2,022
5
null
2,022
2
7
[BACKGROUND] Epstein-Barr virus positivity (EBV+) and microsatellite instability (MSI-high) are positive prognostic factors for survival in resectable gastric cancer (GC). However, benefit of perioperative treatment in patients with MSI-high tumors remains topic of discussion. Here, we present the clinicopathological o...
Histopathological response; Microsatellite instability (MSI); Mucinous differentiation; Stomach neoplasms
2.118
106
Cancer Research; Gastroenterology; Medicine; Oncology
Biochemistry, Genetics and Molecular Biology; Medicine
2,022
35,129,531
Assessing Operative Skill in the Competency-based Education Era: Lessons From the UK and Ireland.
Annals of surgery
Ann Surg
275
4
10.1097/SLA.0000000000005242
eng
2,022
4
1
null
null
null
[INTRODUCTION] Decisions regarding the operative competence of surgical residents in the United Kingdom and Ireland are informed by operative workplace-based assessments (WBAs) and operative number targets for index procedures. This review seeks to outline the validity evidence of these assessment methods. [METHODS] A ...
null
2.951
360
Surgery
Medicine
2,022
35,129,507
Long-Term Outcomes Following Elective Repair of Intact Abdominal Aortic Aneurysms: A Comparison Between Open Surgical and Endovascular Repair Using Linked Administrative and Clinical Registry Data.
Annals of surgery
Ann Surg
277
4
10.1097/SLA.0000000000005259
eng
2,023
4
1
2,021
10
20
[OBJECTIVE] Compare long-term mortality, secondary intervention and secondary rupture following elective endovascular aneurysm repair (EVAR) and open surgical repair (OSR). [BACKGROUND] EVAR has surpassed OSR as the most common procedure used to repair abdominal aortic aneurysm (AAA), but evidence regarding long-term o...
null
2.729
360
Surgery
Medicine
2,023
35,129,475
Long-term Functional Outcomes Among Older Adults Undergoing Video-assisted Versus Open Surgery for Lung Cancer: A Population-based Cohort Study.
Annals of surgery
Ann Surg
277
6
10.1097/SLA.0000000000005387
eng
2,023
6
1
2,022
1
21
[OBJECTIVE] To examine the long-term healthcare dependency outcomes of older adults undergoing VATS compared to open lung cancer resection. [SUMMARY OF BACKGROUND DATA] Although the benefits of VATS for lung cancer resection have been reported, there is a knowledge gap related to long-term functional outcomes central t...
null
2.729
360
Surgery
Medicine
2,023
35,129,418
Risk Factors for Postoperative Ileus in Patients Undergoing Spine Surgery.
Global spine journal
Global Spine J
13
8
10.1177/21925682221075056
eng
2,023
10
null
2,022
2
7
[STUDY DESIGN] Retrospective Cohort Study. [OBJECTIVES] Postoperative ileus (POI) is a common complication following elective spinal surgeries. The aim of this study was to determine the incidence of POI and identify demographic and surgical risk factors for developing POI after elective instrumented fusion of the thor...
complications; ileus; opioid; spine surgery
1.264
59
Neurology; Orthopedics and Sports Medicine; Surgery
Medicine
2,023
35,129,245
Benign acute childhood myositis associated with influenza A/B in the paediatric emergency department and the efficacy of early-onset oseltamivir.
Journal of paediatrics and child health
J Paediatr Child Health
58
6
10.1111/jpc.15894
eng
2,022
6
null
2,022
2
7
[AIM] To investigate the association of benign acute childhood myositis (BACM) with respiratory viruses. Also, we aimed to assess the effect of antiviral treatment on the improvement and complications. [METHODS] This study was conducted at an urban-academic emergency department during four influenza-seasons (2016-2019)...
BACM; children; influenza; myositis; oseltamivir
0.475
90
Pediatrics, Perinatology and Child Health
Medicine
2,022
35,128,954
Acute Effects of Coffee on Peripapillary and Subfoveal Choroidal Parameters in Young Healthy Subjects.
European journal of ophthalmology
Eur J Ophthalmol
32
6
10.1177/11206721221078660
eng
2,022
11
null
2,022
2
7
[PURPOSE] To evaluate the acute effects of coffee on peripapillary and subfoveal choroidal structures using spectral-domain optical coherence tomography (SD-OCT). [MATERIALS AND METHODS] A total of 28 healthy individuals (study group) and 28 healthy controls were enrolled in this study. The peripapillary and subfoveal ...
choroidal vascularity index; coffee; optical coherence tomography; peripapillary choroidal thickness; subfoveal choroidal thickness
0.595
69
Medicine; Ophthalmology
Medicine
2,022
35,128,346
Pregnant women's views on the acceptability, enablers, and barriers of participation in a randomized controlled trial of maternal posture for fetal malposition in labor.
European journal of midwifery
Eur J Midwifery
6
null
10.18332/ejm/144057
eng
2,022
null
null
2,022
1
28
[INTRODUCTION] Fetal malposition in labor results in adverse maternal and infant health. Whilst evidence for effective interventions is inconclusive, based on the hypothesis that gravity corrects malposition, the feasibility and design of a randomized controlled trial (RCT) to improve maternal and infant health outcome...
labor presentation; posture; pregnant women; randomized controlled trial; survey
0.362
13
Maternity and Midwifery; Obstetrics and Gynecology; Pediatrics, Perinatology and Child Health
Medicine; Nursing
2,022
35,128,168
An unusual presentation of peripapillary pachychoroid syndrome.
American journal of ophthalmology case reports
Am J Ophthalmol Case Rep
25
null
10.1016/j.ajoc.2022.101338
eng
2,022
3
null
2,022
1
22
[PURPOSE] Peripapillary pachychoroid syndrome (PPS) is a recently described entity of the pachychoroid disease spectrum and is characterized by thickening of the nasal choroid and peripapillary fluid pockets. This case illustrates the remarkable natural history of this recently described disorder. [OBSERVATION] This ca...
Macular edema; Pachychoroid disease spectrum; Peripapillary pachychoroid syndrome
null
null
null
null
null
35,127,940
Application of Porcine Kidney-Derived Extracellular Matrix as Coating, Hydrogel, and Scaffold Material for Renal Proximal Tubular Epithelial Cell.
BioMed research international
Biomed Res Int
2022
null
10.1155/2022/2220641
eng
2,022
null
null
2,022
1
28
[BACKGROUND] Human renal proximal tubular epithelial (RPTE) cell is a very useful tool for kidney-related experiments in vitro/ex vivo. However, only a few primary RPTE cells can be obtained through kidney biopsy, the proliferation rate of primary cell is very low, and the cultured cell properties are easily altered in...
null
0.64
203
Biochemistry, Genetics and Molecular Biology; Immunology and Microbiology; Medicine
Biochemistry, Genetics and Molecular Biology; Immunology and Microbiology; Medicine
2,022
35,127,784
Prognostic Significance of Modified Advanced Lung Cancer Inflammation Index in Patients With Renal Cell Carcinoma Undergoing Laparoscopic Nephrectomy: A Multi-Institutional, Propensity Score Matching Cohort Study.
Frontiers in nutrition
Front Nutr
8
null
10.3389/fnut.2021.781647
eng
2,021
null
null
2,022
1
20
[BACKGROUND] We conducted a multi-institutional clinical study to assess the prognostic value of the advanced lung cancer inflammatory index (ALI) and modified ALI (mALI) in patients with renal cell carcinoma (RCC). [METHODS] We collected 440 patients who underwent laparoscopic nephrectomy at three centers from 2014 to...
advanced lung cancer inflammatory index; biomarker; modified advanced lung cancer inflammatory index; overall survival; renal cell carcinoma
1.024
94
Endocrinology, Diabetes and Metabolism; Food Science; Nutrition and Dietetics
Agricultural and Biological Sciences; Medicine; Nursing
2,021
35,127,489
The Clinical Aspects and Prognostic Factors Concerning Survival in Patients With Recurrent Cervical Cancer After Radical Hysterectomy and Adjuvant Chemoradiotherapy.
Frontiers in oncology
Front Oncol
11
null
10.3389/fonc.2021.782403
eng
2,021
null
null
2,022
1
21
[PURPOSE] To investigate the recurrence patterns and prognostic factors of patients with recurrent cervical cancer after radical hysterectomy with node dissection (RHND) followed by adjuvant radiotherapy (RT)/concurrent chemoradiotherapy (CCRT). [METHODS] The medical records of 153 patients with pre-operative Internati...
chemotherapy; prognostic factors; radical surgery; radiotherapy; recurrent cervical cancer; survival
1.291
156
Oncology; Cancer Research
Biochemistry, Genetics and Molecular Biology; Medicine
2,021
35,127,273
Can Community Gardens with Workshops Increase Gardening Behavior? A Navajo Wellness Collaboration.
Journal of health disparities research and practice
J Health Dispar Res Pract
14
2
null
eng
2,021
null
null
null
null
null
[UNLABELLED] This project evaluated the potential efficacy of a community gardening intervention on the Navajo Nation to increase gardening and healthy eating behaviors, which are potentially important in preventing obesity and related health conditions. Rates of obesity are high among American Indians, including those...
null
null
null
null
null
null
35,126,790
Tooth Loss after Jaw Curettage Surgery: Associated Factors and Potential Benefit of Splint Application.
Disease markers
Dis Markers
2022
null
10.1155/2022/7750229
eng
2,022
null
null
2,022
1
28
[BACKGROUND] This retrospective study is aimed at (I) assessment of tooth loss and related parameters after jaw curettage of benign lesions and (II) assessment of the outcome of jaw curettage supported by splint insertion after at least six months of follow-up. Material and Methods. For (I), patients who had jaw curett...
null
0.662
85
Biochemistry; Clinical Biochemistry; Medicine; Genetics; Molecular Biology
Biochemistry, Genetics and Molecular Biology; Medicine
2,022
35,126,538
A neuroanatomical study of the feline brain using MRI and mulligan staining: functional and pathological considerations.
Iranian journal of veterinary research
Iran J Vet Res
22
4
10.22099/ijvr.2021.39886.5785
eng
2,021
null
null
null
null
null
[BACKGROUND] Despite multiple studies describing accurate diagnoses using advanced neuroimaging techniques, low and mid-field magnetic resonance imaging (MRI) are still the most frequent scanners in veterinary clinics. To date, these studies in cats do not show a clear distinction of nerve centres in MRI data. [AIMS] T...
Feline; MRI; Mulligan staining; Nervous nuclei; Neuroanatomy
null
null
null
null
null
35,126,315
Status of Analgesic Drugs and Quality of Life Results for Diabetic Peripheral Neuropathy in China.
Frontiers in endocrinology
Front Endocrinol (Lausanne)
12
null
10.3389/fendo.2021.813210
eng
2,021
null
null
2,022
1
21
[OBJECTIVE] The purpose of this study is to describe the current clinical situation of patients with painful diabetic peripheral neuropathy (DPN) and related anxiety, depression, and the quality of life of patients in mainland China, and to report the current status of the use of analgesics. [METHODS] Between June 15, ...
GAD-7; NRS; PHQ-9; analgesics; diabetic peripheral neuropathy
1.375
138
Endocrinology, Diabetes and Metabolism
Medicine
2,021
35,126,285
Case Report: Four Cases of Cortical/Brainstem Encephalitis Positive for Myelin Oligodendrocyte Glycoprotein Immunoglobulin G.
Frontiers in neurology
Front Neurol
12
null
10.3389/fneur.2021.775181
eng
2,021
null
null
2,022
1
21
[AIM] Despite a significant improvement in the number of studies on myelin oligodendrocyte glycoprotein (MOG)-immunoglobulin G (IgG)-associated disorder (MOGAD) over the past few years, MOG-IgG-associated cortical/brainstem encephalitis remains a relatively uncommon and less-reported presentation among the MOGAD spectr...
brainstem encephalitis; cortical encephalitis; epileptic seizures; myelin oligodendrocyte glycoprotein; neuromyelitis optica spectrum disorder
1.027
118
Neurology; Neurology
Medicine; Neuroscience
2,021
35,126,214
Personality and Peripartum Changes in Perceived Social Support: Findings From Two Prospective-Longitudinal Studies in (Expectant) Mothers and Fathers.
Frontiers in psychiatry
Front Psychiatry
12
null
10.3389/fpsyt.2021.814152
eng
2,021
null
null
2,022
1
20
[OBJECTIVE] The aim of this study was to examine changes in perceived social support from early pregnancy to 2 years postpartum and to test whether these changes (a) differ between mothers and fathers or (b) vary as a function of the Big Five personality traits. [BACKGROUND] Higher peripartum social support in (expecta...
DREAM study; MARI study; longitudinal; personality; pregnancy; relationship processes; social support
1.279
134
Psychiatry and Mental Health
Medicine
2,021
35,125,892
Clinical Non-Adherence and Its Associated Factors Among HIV-Positive Pediatric Patients Attending HIV Care in South Gondar Zone Public Health Facilities, Northwest Ethiopia, 2021.
HIV/AIDS (Auckland, N.Z.)
HIV AIDS (Auckl)
14
null
10.2147/HIV.S352386
eng
2,022
null
null
2,022
1
29
[BACKGROUND] Poor clinical adherence is the main factor that hinders ART adherence level in children and its ultimate effect on viral load suppression and decreasing morbidity and mortality of children. Although data from different settings are necessary to tackle such types of problems, the pieces of evidence are limi...
Ethiopia; adherence; antiretroviral; pediatrics; south Gondar
null
null
null
null
null
35,125,863
Relationship Between Anti-DFS70 Autoantibodies and Oxidative Stress.
Biomarker insights
Biomark Insights
17
null
10.1177/11772719211066791
eng
2,022
null
null
2,022
1
30
[BACKGROUND] The anti-DFS70 autoantibodies are one of the most commonly and widely described agent of unknown clinical significance, frequently detected in healthy individuals. It is not known whether the DFS70 autoantibodies are protective or pathogenic. One of the factors suspected of inducing the formation of anti-D...
Antibodies; biomarkers; free radicals; oxidative stress
0.878
43
Biochemistry; Molecular Medicine; Pharmacology
Biochemistry, Genetics and Molecular Biology; Medicine; Pharmacology, Toxicology and Pharmaceutics
2,022
35,125,830
Knockdown of DEAD-box 51 inhibits tumor growth of esophageal squamous cell carcinoma via the PI3K/AKT pathway.
World journal of gastroenterology
World J Gastroenterol
28
4
10.3748/wjg.v28.i4.464
eng
2,022
1
28
null
null
null
[BACKGROUND] Esophageal squamous cell carcinoma (ESCC) is one of the most prevalent malignancies that seriously threaten people's health worldwide. DEAD-box helicase 51 (DDX51) is a member of the DEAD-box (DDX) RNA helicase family, and drives or inhibits tumor progression in multiple cancer types. [AIM] To determine wh...
DDX51; Esophageal squamous cell carcinoma; PI3K/AKT pathway; Therapeutic target; Tumor growth
null
null
null
null
null
35,125,798
Efficacy of Botulinum Toxin Injection in Exotropia Treatment.
Middle East African journal of ophthalmology
Middle East Afr J Ophthalmol
28
3
10.4103/meajo.meajo_269_21
eng
2,021
null
null
2,021
12
31
[PURPOSE] Botulinum toxin (Botox) therapy is a well-known option for strabismus management and is often used in managing esotropia. Exotropia is also a common type of strabismus; however, the effectiveness of Botox in improving exotropia is still ambiguous. In this study, we report our experience in using Botox to mana...
Botulinum toxin; exotropia; strabismus
0.34
39
Medicine; Ophthalmology
Medicine
2,021
35,125,411
The Effect of Gadolinium-Based Contrast Agents on Longitudinal Changes of Magnetic Resonance Imaging Signal Intensities and Relaxation Times in the Aging Rat Brain.
Investigative radiology
Invest Radiol
57
7
10.1097/RLI.0000000000000857
eng
2,022
7
1
2,022
2
4
[OBJECTIVES] The aim of the study was to investigate the possible influence of changes in the brain caused by age on relaxometric and relaxation time-weighted magnetic resonance imaging (MRI) parameters in the deep cerebellar nuclei (DCN) and the globus pallidus (GP) of Gd-exposed and control rats over the course of 1 ...
null
2.414
132
Medicine; Radiology, Nuclear Medicine and Imaging
Medicine
2,022
35,125,121
MCM6 versus Ki-67 in diagnosis of luminal molecular subtypes of breast cancers.
Diagnostic pathology
Diagn Pathol
17
1
10.1186/s13000-022-01209-4
eng
2,022
2
6
2,022
2
6
[BACKGROUND] Currently, breast cancers are divided into four major molecular subtypes. The distinction between the luminal A and luminal B subtypes is mainly based on the cellular proliferation indices and is assessed by the Ki-67 scoring. Due to the limitations in the assessment and expression of Ki-67, we hypothesize...
Biomarkers; Breast cancer; Diagnostic; Ki67; Luminal B; Luminal a; MCM6
0.677
66
Histology; Medicine; Pathology and Forensic Medicine
Medicine
2,022
35,125,113
Systematic review and meta-analysis of the diagnostic accuracy of prostate-specific antigen (PSA) for the detection of prostate cancer in symptomatic patients.
BMC medicine
BMC Med
20
1
10.1186/s12916-021-02230-y
eng
2,022
2
7
2,022
2
7
[BACKGROUND] Prostate-specific antigen (PSA) is a commonly used test to detect prostate cancer. Attention has mostly focused on the use of PSA in screening asymptomatic patients, but the diagnostic accuracy of PSA for prostate cancer in patients with symptoms is less well understood. [METHODS] A systematic database sea...
Diagnostic accuracy; LUTS; Lower urinary tract symptoms; PSA; Primary care; Prostate cancer; Prostate-specific antigen; Secondary care
3.447
199
Medicine
Medicine
2,022
35,124,922
Comparative Behaviour Problems Among Primary School Children Of Grade-5 In Public Private Schools Of Lahore: Teacher Parent Reporting.
Journal of Ayub Medical College, Abbottabad : JAMC
J Ayub Med Coll Abbottabad
33
4
null
eng
2,021
null
null
null
null
null
[BACKGROUND] The World Health Organization (WHO) estimated that about 10-20% of children worldwide have mental or behavioural problems. Objectives of the study were 1) To determine the prevalence of behavioural problems among primary school children of grade-5 in public and private schools of Lahore upon teachers and p...
Parents; Strength and Difficulty Questionnaire
null
null
null
null
null
35,124,913
Outcome Of Endodontic Procedures Performed By Dental Interns Using Stainless Steel And Niti Files: A 10- Year Retrospective Study.
Journal of Ayub Medical College, Abbottabad : JAMC
J Ayub Med Coll Abbottabad
33
4
null
eng
2,021
null
null
null
null
null
[BACKGROUND] Preparation of root canal according to its desired anatomy and complete disinfection is a laborious task. Several factors influence the endodontic treatment including operator's skill and knowledge, anatomy of the tooth, the instruments and equipment used. In the past stainless-steel instruments were used ...
Dental Interns; Endodontic performance; Nickle Titanium Protaper; Stainless steel
null
null
null
null
null
35,124,715
An increased posterior tibial slope is associated with a higher risk of graft failure following ACL reconstruction: a systematic review.
Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA
Knee Surg Sports Traumatol Arthrosc
30
7
10.1007/s00167-022-06888-6
eng
2,022
7
null
2,022
2
6
[PURPOSE] The posterior tibial slope (PTS) is considered a risk factor for anterior cruciate ligament (ACL) injury. However, the influence of PTS on graft failure following ACL reconstruction remains relatively unknown. Therefore, this systematic review was conducted to investigate whether PTS could be a potential risk...
Anterior cruciate ligament reconstruction; Graft failure; Posterior tibial slope; Systematic review
1.789
160
Orthopedics and Sports Medicine; Sports Science; Surgery
Health Professions; Medicine
2,022
35,124,620
Clinical value and application of preoperative CT-guided hookwire localization of solitary pulmonary nodules for video-assisted thoracic surgery.
Technology and health care : official journal of the European Society for Engineering and Medicine
Technol Health Care
30
S1
10.3233/THC-THC228042
eng
2,022
null
null
null
null
null
[BACKGROUND] Video-assisted thoracic surgery (VATS) is a minimally invasive technique for the diagnosis and management of small pulmonary nodular lesions However, the identification of some lung nodules remains difficult. [OBJECTIVE] This research aimed to investigate the clinical value of preoperative computed tomogra...
CT-guided; Solitary pulmonary nodules; hookwire; video-assisted thoracic surgery
null
null
null
null
null
35,124,601
Fisheye lens design for solar-powered mobile ultrasound devices.
Technology and health care : official journal of the European Society for Engineering and Medicine
Technol Health Care
30
S1
10.3233/THC-228023
eng
2,022
null
null
null
null
null
[BACKGROUND] Compared to benchtop ultrasound machines, mobile ultrasound machines require portable batteries when acquiring information regarding human tissues during outdoor activities. [OBJECTIVE] A novel fisheye lens type was designed to address the charging issue where it is difficult to constantly track the sun. T...
Mobile ultrasound machines; fisheye lens; solar power
null
null
null
null
null
35,123,504
Psychometric evaluation of the Coronary Revascularisation Outcome Questionnaire (CROQ) in Norwegian patients admitted to elective coronary angiography and possible percutaneous coronary intervention.
Health and quality of life outcomes
Health Qual Life Outcomes
20
1
10.1186/s12955-022-01927-9
eng
2,022
2
5
2,022
2
5
[BACKGROUND] The Coronary Revascularisation Outcome Questionnaire (CROQ) measures health-related quality of life and outcome of invasive revascularization procedures such as percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG). The CROQ has not been properly validated in Norwegian patient ...
Coronary heart disease; Coronary revascularisation outcome questionnaire; Health-related quality of life; Patient reported outcome measures; Percutaneous coronary intervention; Psychometric properties
0.993
144
Medicine; Public Health, Environmental and Occupational Health
Medicine
2,022
35,123,437
Long-term efficacy and safety of SARS-CoV-2 vaccination in patients with chronic kidney disease, on dialysis or after kidney transplantation: a national prospective observational cohort study.
BMC nephrology
BMC Nephrol
23
1
10.1186/s12882-022-02680-3
eng
2,022
2
5
2,022
2
5
[BACKGROUND] COVID-19 is associated with increased morbidity and mortality in patients with chronic kidney disease (CKD) stages G4-G5, on dialysis or after kidney transplantation (kidney replacement therapy, KRT). SARS-CoV-2 vaccine trials do not elucidate if SARS-CoV-2 vaccination is effective in these patients. Vacci...
Antibody response; Chronic kidney disease; Dialysis; Efficacy; Kidney transplantation; SARS-CoV-2; Safety; Vaccine
0.746
83
Nephrology
Medicine
2,022
35,123,404
Construction and comprehensive analysis of the competing endogenous RNA network in endometrial adenocarcinoma.
BMC genomic data
BMC Genom Data
23
1
10.1186/s12863-022-01028-y
eng
2,022
2
6
2,022
2
6
[BACKGROUND] Endometrial carcinoma (EC) is one of the most common gynecological malignant tumors. In this study, we constructed gene co-expression networks to identify key modules and hub genes involved in the pathogenesis of EC. [RESULTS] The MEturquoise module was found to be significantly related to hypertension and...
Competing endogenous RNAs co-expression; Endometrial carcinoma; Hub gene; Weighted gene co-expression network analysis
null
null
null
null
null
35,123,340
The impact of COVID-19 on patients with OCD: A one-year follow-up study.
Journal of psychiatric research
J Psychiatr Res
147
null
10.1016/j.jpsychires.2022.01.065
eng
2,022
3
null
2,022
2
1
[BACKGROUND] Since the onset of the COVID-19 pandemic, concerns regarding its psychological effects on people with preexisting psychiatric disorders have been raised, particularly obsessive-compulsive disorder (OCD). Nevertheless, only a few longitudinal studies have been performed, and a more longstanding follow-up of...
COVID-19; Obsessive-compulsive disorder; Psychological distress
1.554
172
Biological Psychiatry; Psychiatry and Mental Health
Medicine; Neuroscience
2,022
35,123,335
Neurocognitive functioning and impulsivity in first-episode psychosis with suicidal ideation and behavior: A systematic review.
Schizophrenia research
Schizophr Res
241
null
10.1016/j.schres.2022.01.042
eng
2,022
3
null
2,022
2
2
[BACKGROUND] The prevalence of suicidal ideation (SI) and behavior (SB) among people suffering from psychotic disorders is a public health issue. Most suicide attempts (SAs) occur before or during the early phases of first-episode psychosis (FEP). Improving knowledge about the suicide risk in the early stages is essent...
Impulsive behavior; Mental processes; Neuropsychology; Psychotic disorder; Self-injurious behavior; Suicide
1.429
204
Psychiatry and Mental Health; Biological Psychiatry
Medicine; Neuroscience
2,022
35,123,282
Multi-type childhood maltreatment exposure and substance use development from adolescence to early adulthood: A GxE study.
Child abuse neglect
Child Abuse Negl
126
null
10.1016/j.chiabu.2022.105508
eng
2,022
4
null
2,022
2
2
[BACKGROUND] Childhood maltreatment types can co-occur and are associated with increased substance use during adolescence and early adulthood. There is also a strong genetic basis for substance use which interacts with environmental factors (e.g., childhood maltreatment) to influence substance use phenotype. [OBJECTIVE...
Gene-environment interaction; Longitudinal; Polygenic risk score; Substance use
null
null
null
null
null
35,123,159
The Care Dependency Scale: A cross validation study in inpatients with cancer.
European journal of oncology nursing : the official journal of European Oncology Nursing Society
Eur J Oncol Nurs
56
null
10.1016/j.ejon.2021.102087
eng
2,022
2
null
2,021
12
22
[PURPOSE] Inpatients with cancer are likely to experience care dependency and would benefit from nurses' evaluation of such dependency. The Care Dependency Scale (CDS) is a 15-item instrument widely used to assess patients' dependency in different populations and settings. This study aimed to test the psychometric prop...
Adult; Cancer; Care dependency scale; Factor analysis; Nursing care; Psychometrics; Validation studies
0.68
74
Oncology; Medicine
Medicine; Nursing
2,022
35,123,122
Development of a Health Promotion Application on Cancer Survivorship as an Educational Content for Nursing Students.
Asian nursing research
Asian Nurs Res (Korean Soc Nurs Sci)
16
1
10.1016/j.anr.2022.01.002
eng
2,022
2
null
2,022
2
3
[PURPOSE] This study aimed to develop a health promotion application for cancer survivorship (CS app) based on the adult learning and self-efficacy theories and evaluated its usability as an educational tool for nursing students. [METHODS] The CS app was developed according to ADDIE (analysis, design, development, impl...
education; mobile applications; nursing; student
0.662
45
Nursing; Medicine
Medicine; Nursing
2,022
35,123,110
Risk factors for preterm birth among gravid individuals receiving buprenorphine for opioid use disorder.
American journal of obstetrics gynecology MFM
Am J Obstet Gynecol MFM
4
3
10.1016/j.ajogmf.2022.100582
eng
2,022
5
null
2,022
2
2
[BACKGROUND] Opioid use disorder (OUD) has dramatically increased over the last few decades, with 11.5 million American misusing opioids in 2016. Untreated OUD in pregnancy is associated with unique adverse obstetric and perinatal outcomes including insufficient prenatal care, preterm birth (PTB), fetal growth restrict...
buprenorphine; medication for opioid use disorder; opioid use disorder; preterm
null
null
null
null
null
35,123,013
Quantitative changes in peripapillary, macular, and choriocapillaris microvasculature of patients with non-ocular Behçet's disease and relationship with systemic vascular involvement, an optical coherence tomography angiography study.
Photodiagnosis and photodynamic therapy
Photodiagnosis Photodyn Ther
38
null
10.1016/j.pdpdt.2022.102749
eng
2,022
6
null
2,022
2
3
[BACKGROUND] To evaluate the changes in the peripapillary, macular and choriocapillaris microvasculatures in the eyes of patients with Behçet's disease (BD) without ocular involvement by optical coherence tomography angiography (OCT-A) and to investigate the relationship with systemic vascular involvement (SVI). [METHO...
Choriocapillaris; Optic nerve head analysis; Optical coherence tomography angiography; Radial peripapillary capillary vessel density; Systemic vascular involvement
0.633
73
Biophysics; Dermatology; Pharmacology; Oncology
Biochemistry, Genetics and Molecular Biology; Medicine
2,022
35,122,610
Coping strategies and quality of life in patients with chronic symptoms visiting a Lyme Center in a Dutch teaching hospital.
Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation
Qual Life Res
31
8
10.1007/s11136-022-03094-2
eng
2,022
8
null
2,022
2
5
[INTRODUCTION] Little is known on coping strategies in patients with chronic symptoms suspected of Lyme borreliosis (LB). Different coping strategies might influence quality of life (QoL). We assessed coping strategies and QoL in patients with chronic symptoms suspected of LB. [METHODS] Adult patients referred to the L...
Borrelia burgdorferi; Coping; Lyme borreliosis; Lyme disease; Quality of life; RAND-36; UCL
1.198
179
Public Health, Environmental and Occupational Health
Medicine
2,022
35,122,565
To share or not to share: communication of caregiver-reported outcomes when a patient has colorectal cancer.
Journal of patient-reported outcomes
J Patient Rep Outcomes
6
1
10.1186/s41687-022-00418-1
eng
2,022
2
5
2,022
2
5
[BACKGROUND] The importance of patient-centered measurement in cancer care has led to recognition of the potential for caregiver-reported outcomes to improve caregiver, patient and healthcare system outcomes. Yet, there is limited evidence to inform caregiver-reported outcome implementation. Our purpose was to generate...
Caregiver; Caregiver-reported outcomes; Colorectal cancer; Family; Interpretive description; Measurement; Oncology; Psychosocial; Qualitative research; Supportive care
0.729
35
Health Informatics; Health Information Management
Health Professions; Medicine
2,022
35,122,406
Multi-institutional expert update on the use of laparoscopic bile duct exploration in the management of choledocholithiasis: Lesson learned from 3950 procedures.
Journal of hepato-biliary-pancreatic sciences
J Hepatobiliary Pancreat Sci
29
12
10.1002/jhbp.1123
eng
2,022
12
null
2,022
2
17
[BACKGROUND] Recently there has been a growing interest in the laparoscopic management of common bile duct stones with gallbladder in situ (LBDE), which is favoring the expansion of this technique. Our study identified the standardization factors of LBDE and its implementation in the single-stage management of choledoc...
bile duct exploration; biliary tract; cystic duct; laparoscopy; lithiasis
0.903
108
Surgery; Hepatology
Medicine
2,022
35,122,318
Glandular odontogenic cysts: A collaborative investigation of 22 cases and proteins related to invasiveness.
Journal of oral pathology medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
J Oral Pathol Med
51
4
10.1111/jop.13283
eng
2,022
4
null
2,022
2
9
[BACKGROUND] A glandular odontogenic cyst (GOC) has an intriguing, aggressive behaviour whose mechanisms have not yet been clarified. [OBJECTIVE] To conduct a collaborative cross-sectional study on the clinical, demographic, microscopic and immunohistochemical characteristics of GOCs, emphasizing the histopathological ...
cortactin; glandular odontogenic cyst; immunohistochemistry; invadopodia; odontogenic cysts
null
null
null
null
null
35,122,134
Neovascular age-related macular degeneration: advancement in retinal imaging builds a bridge between histopathology and clinical findings.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
Graefes Arch Clin Exp Ophthalmol
260
7
10.1007/s00417-022-05577-x
eng
2,022
7
null
2,022
2
5
[PURPOSE] To provide a review of the salient histological and imaging features in neovascular age-related macular degeneration (AMD) that will be integrated in order to have a better comprehension of the pathogenesis and clinical aspects of this disease. [METHODS] A literature review of histology and imaging features i...
Age-related macular degeneration; Drusen; Geographic atrophy; Histology; Imaging; Macular neovascularization; Optical coherence tomography; Optical coherence tomography angiography
null
null
null
null
null
35,122,103
The value of fibular fixation in patients with stabilized distal tibia fractures.
European journal of trauma and emergency surgery : official publication of the European Trauma Society
Eur J Trauma Emerg Surg
48
4
10.1007/s00068-022-01888-0
eng
2,022
8
null
2,022
2
4
[PURPOSE] There is currently no consensus regarding the need for fixation of concomitant fibula fractures in patients with surgically treated distal tibia fracture. Although studies have shown it to be beneficial for fractures involving the syndesmosis, it remains unclear for suprasyndesmotic fractures. This study eval...
Distal tibia fracture; Fibula fracture; Osteosynthesis; Suprasyndesmotic
0.565
54
Critical Care and Intensive Care Medicine; Emergency Medicine; Orthopedics and Sports Medicine; Surgery
Medicine
2,022
35,121,608
Primary care-based interventions addressing social isolation and loneliness in older people: a scoping review.
BMJ open
BMJ Open
12
2
10.1136/bmjopen-2021-057729
eng
2,022
2
4
2,022
2
4
[OBJECTIVES] Primary care is well positioned to identify and address loneliness and social isolation in older adults, given its gatekeeper function in many healthcare systems. We aimed to identify and characterise loneliness and social isolation interventions and detect factors influencing implementation in primary car...
geriatric medicine; mental health; organisation of health services; primary care; social medicine
1.059
176
Medicine
Medicine
2,022
35,121,161
Ceftolozane-tazobactam vs. colistin for the treatment of infections due to multidrug-resistant Pseudomonas aeruginosa: a multicentre cohort study.
Journal of global antimicrobial resistance
J Glob Antimicrob Resist
28
null
10.1016/j.jgar.2022.01.023
eng
2,022
3
null
2,022
2
1
[OBJECTIVES] The aim of this study was to compare the safety and effectiveness of ceftolozane-tazobactam (C-T) to colistin-based regimen for treating infections caused by multidrug-resistant (MDR) Pseudomonas aeruginosa. [METHODS] This was a retrospective, multicentre, observational cohort study of inpatients who recei...
Ceftolozane-tazobactam; Colistin; Multidrug-resistant; Pseudomonas aeruginosa
0.879
55
Immunology; Immunology and Allergy; Microbiology; Microbiology
Immunology and Microbiology; Medicine
2,022
35,120,745
Reproductive function in men conceived with in vitro fertilization and intracytoplasmic sperm injection.
Fertility and sterility
Fertil Steril
117
4
10.1016/j.fertnstert.2021.12.026
eng
2,022
4
null
2,022
2
2
[OBJECTIVE] To determine the semen quality and reproductive hormones of men conceived by in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) compared with men conceived without assisted reproductive technology (ART). [DESIGN] Cohort study. [SETTING] IVF centers in Victoria and the Western Australia...
ICSI; fertility; male; reproductive health; semen analysis
1.579
252
Obstetrics and Gynecology; Reproductive Medicine
Medicine
2,022
35,120,532
Alcohol outlets and alcohol consumption in changing environments: prevalence and changes over time.
Substance abuse treatment, prevention, and policy
Subst Abuse Treat Prev Policy
17
1
10.1186/s13011-021-00430-6
eng
2,022
2
4
2,022
2
4
[BACKGROUND] To examine whether changes in density of neighborhood alcohol outlets affected changes in alcohol consumption 1-year after regulatory changes increased alcohol availability. [METHODS] Person-level data came from a population-based cohort (aged 21-64) residing in/around the Philadelphia, Pennsylvania metrop...
Alcohol consumption; Alcohol outlets; Epidemiology; Public health; Public policy
null
null
null
null
null
35,120,476
The effect of training the fathers to support their wives on stress and self-efficacy in mothers of premature newborns hospitalized in NICU: a quasi-experimental study.
BMC pregnancy and childbirth
BMC Pregnancy Childbirth
22
1
10.1186/s12884-022-04413-8
eng
2,022
2
4
2,022
2
4
[BACKGROUND] The birth of premature newborns and their separation from family due to their hospitalization in the Neonatal Intensive Care Unit (NICU) cause stress in the parents, especially mothers. We conducted this study aimed to evaluate whether training the fathers to support their wives impacts premature newborn m...
Fathers; Mothers; Neonatal intensive care units; Self-efficacy; Stress; Training
1.034
122
Obstetrics and Gynecology
Medicine
2,022
35,120,151
Influence of preoperative frailty on quality of life after cardiac surgery: Protocol for a systematic review and meta-analysis.
PloS one
PLoS One
17
2
10.1371/journal.pone.0262742
eng
2,022
null
null
2,022
2
4
[BACKGROUND] Frailty has emerged as an important prognostic marker of adverse outcomes after cardiac surgery, but evidence regarding its ability to predict quality of life after cardiac surgery is currently lacking. Whether frail patients derive the same quality of life benefit after cardiac surgery as patients without...
null
0.885
467
Multidisciplinary
Multidisciplinary
2,022
35,120,067
Utilization of Medications for Opioid Use Disorder Across US States: Relationship to Treatment Availability and Overdose Mortality.
Journal of addiction medicine
J Addict Med
16
1
10.1097/ADM.0000000000000820
eng
null
null
null
null
null
null
[OBJECTIVE] Availability of medications for opioid use disorder (MOUD) remains sparse. To date, there has been no national, state-by-state comparison of patient MOUD utilization relative to treatment availability and burden of overdose deaths. We aimed to quantify, for each state, the number of MOUD patients relative t...
null
null
null
null
null
null
35,119,908
Sex Differences in Risk of Severe Adverse Events in Patients Receiving Immunotherapy, Targeted Therapy, or Chemotherapy in Cancer Clinical Trials.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
J Clin Oncol
40
13
10.1200/JCO.21.02377
eng
2,022
5
1
2,022
2
4
[PURPOSE] Women have more adverse events (AEs) from chemotherapy than men, but few studies have investigated sex differences in immune or targeted therapies. We examined AEs by sex across different treatment domains. [METHODS] We analyzed treatment-related AEs by sex in SWOG phase II and III clinical trials conducted b...
null
10.163
646
Cancer Research; Medicine; Oncology
Biochemistry, Genetics and Molecular Biology; Medicine
2,022
35,119,799
High score of dizziness-handicap-inventory (DHI) in patients with chronic musculoskeletal pain makes a chronic vestibular disorder probable.
Scandinavian journal of pain
Scand J Pain
22
3
10.1515/sjpain-2021-0102
eng
2,022
7
26
2,022
2
7
[OBJECTIVES] In patients with a vestibular disorder a high score of dizziness-handicap-inventory (DHI) is common. Patients with chronic lithiasis of multiple canals benign paroxysmal positional vertigo (mc-BPPV) can have incapacitating symptoms, e.g. headache, neck pain, musculoskeletal pain, and cognitive dysfunction....
benign paroxysmal positional vertigo; biopsychosocial disorder; dizziness; headache; vertigo
0.534
39
Anesthesiology and Pain Medicine; Neurology
Medicine
2,022
35,119,703
Cancer disparities among non-Hispanic urban American Indian and Alaska Native populations in the United States, 1999-2017.
Cancer
Cancer
128
8
10.1002/cncr.34122
eng
2,022
4
15
2,022
2
4
[BACKGROUND] Disparities in cancer incidence have not been described for urban American Indian/Alaska Native (AI/AN) populations. The purpose of the present study was to examine incidence rates (2008-2017) and trends (1999-2017) for leading cancers in urban non-Hispanic AI/AN (NH AI/AN) compared to non-Hispanic White (...
Alaska Native; American Indian; cancer incidence; health disparity; trends; urban
2.736
349
Cancer Research; Oncology
Biochemistry, Genetics and Molecular Biology; Medicine
2,022
35,119,607
Visual functional defects in patients with type 2 diabetes mellitus: a questionnaire based cross-sectional study.
International ophthalmology
Int Ophthalmol
42
7
10.1007/s10792-022-02220-w
eng
2,022
7
null
2,022
2
4
[PURPOSE] To determine the impact of type 2 diabetes mellitus (T2DM) on visual functions, identify different modifiers as risk or protective factors, and find out how these factors affect patients' visual symptoms and visual functions as a whole. [METHODS] We performed an online survey among 1030 participants (400 pati...
Quality of life; Retinopathy; Type 2 diabetes; Visual functions
0.587
57
Ophthalmology
Medicine
2,022
35,119,513
Long-Term Outcome of Patients with Postoperative Refractory Diarrhea After Tailored Nerve Plexus Dissection Around the Major Visceral Arteries During Pancreatoduodenectomy for Pancreatic Cancer.
World journal of surgery
World J Surg
46
5
10.1007/s00268-022-06457-5
eng
2,022
5
null
2,022
2
4
[BACKGROUND] For pancreatic ductal adenocarcinoma (PDAC) surgery, extended dissection of the nerve plexus (pl) around the superior mesenteric artery (SMA) or celiac artery (CA) is sometimes necessary. This consequently results in postoperative refractory diarrhea. This study aimed to evaluate the clinical impact of ext...
null
0.902
176
Surgery
Medicine
2,022
35,119,486
Ipsilateral femoral neck and shaft fractures: case series from a single Level-I trauma centre and review of literature.
European journal of orthopaedic surgery traumatology : orthopedie traumatologie
Eur J Orthop Surg Traumatol
33
4
10.1007/s00590-021-03199-3
eng
2,023
5
null
2,022
2
4
[INTRODUCTION] Uncommon but increasingly diagnosed, ipsilateral femoral neck and shaft fracture represents a complex injury pattern with challenging management. The conundrum involves optimal diagnostic modality, timing of surgery, sequence of fixation, and the choice of implant. [METHODOLOGY] A retrospective review wa...
Dual vs single implant; Ipsilateral femoral neck and shaft fracture
null
null
null
null
null
35,119,089
Higher rate of COVID-19 mortality in patients with type 1 than type 2 diabetes: a nationwide study.
Endokrynologia Polska
Endokrynol Pol
73
1
10.5603/EP.a2022.0008
eng
2,022
null
null
2,022
2
4
[INTRODUCTION] COVID-19 disease has a worse prognosis in patients with diabetes, but comparative data about the course of COVID-19 in patients with type 1 (T1DM) and type 2 diabetes (T2DM) are lacking. The purpose of this study was to find out the relative clinical severity and mortality of COVID-19 patients with T1DM ...
COVID-19; T1DM; Turkey; coronavirus; diabetes mellitus; mortality; type 1 diabetes
0.346
39
Endocrinology, Diabetes and Metabolism; Endocrinology
Biochemistry, Genetics and Molecular Biology; Medicine
2,022
35,119,039
Angiogenin and MMP-2 as potential biomarkers in the differential diagnosis of gestational trophoblastic diseases.
Medicine
Medicine (Baltimore)
101
5
10.1097/MD.0000000000028768
eng
2,022
2
4
null
null
null
[BACKGROUND] Gestational trophoblastic diseases (GTDs) are characterized by vascular abnormalities of the trophoblast, but their pathogenesis is unknown. Angiogenin (ANG) and matrix metalloproteinase (MMP)-2, which are molecules implicated in the angiogenic process, may play some role in this process. [MATERIAL AND MET...
null
null
null
null
null
null
35,118,960
Effect of focal and diffuse hypervascularization as cystoscopic findings on predicting intravesical therapy response in patients with bladder pain syndrome.
Turkish journal of urology
Turk J Urol
47
4
10.5152/tju.2021.21093
eng
2,021
7
null
null
null
null
[OBJECTIVE] To define the relationship between cystoscopic findings, including novel findings such as the hypervascularization, of bladder pain syndrome/interstitial cystitis (BPS/IC) and the response to intravesical therapy. [MATERIAL AND METHODS] We retrospectively evaluated cystoscopy findings in patients who had a ...
null
0.322
0
Urology
Medicine
2,021
35,118,895
Ophthalmological findings in children with unicoronal craniosynostosis.
European journal of ophthalmology
Eur J Ophthalmol
32
6
10.1177/11206721221077548
eng
2,022
11
null
2,022
2
4
[INTRODUCTION] Among non-syndromic, single-suture craniosynostoses, unicoronal craniosynostosis (UCS) presents the highest rate of ophthalmic manifestations requiring a visual follow-up, due to the high risk of amblyopia. After birth or during childhood, children with UCS have a high risk to present an aniso-astigmatis...
amblyopia; craniofacial abnormalities; genetic disease; orbital disease; strabismus
0.595
69
Medicine; Ophthalmology
Medicine
2,022
35,118,586
Efficacy, safety, and optimal timing of single-trocar video-assisted flexible thoracoscopic debridement under local anesthesia for complicated parapneumonic empyema.
General thoracic and cardiovascular surgery
Gen Thorac Cardiovasc Surg
70
7
10.1007/s11748-022-01780-z
eng
2,022
7
null
2,022
2
3
[OBJECTIVE] Thoracoscopic debridement under local anesthesia is a useful approach for complicated parapneumonic effusion or empyema (CPE) and is a less invasive procedure than video-assisted thoracoscopic surgery under general anesthesia. There are various methods of thoracoscopic debridement under local anesthesia, al...
Empyema; Local anesthesia; Pleural infection; Thoracoscopy; Video-assisted thoracoscopic surgery
0.481
50
Surgery; Cardiology and Cardiovascular Medicine; Medicine; Pulmonary and Respiratory Medicine
Medicine
2,022
35,118,569
Identification and characterization of stress responsive homeodomain leucine zipper transcription factors in Medicago truncatula.
Molecular biology reports
Mol Biol Rep
49
5
10.1007/s11033-022-07197-4
eng
2,022
5
null
2,022
2
3
[BACKGROUND] Homeodomain leucine zipper (HD-ZIP) transcription factors play roles in regulating plant development and responses to abiotic stresses; however, how HD-ZIP genes in Medicago truncatula are involved in abiotic stress response remains elusive. [METHODS AND RESULTS] The HD-ZIP I genes in Medicago truncatula w...
Abiotic stresses; Expression profile; HD-ZIP I transcription factor; Medicago truncatula
0.578
96
Medicine; Genetics; Molecular Biology
Biochemistry, Genetics and Molecular Biology; Medicine
2,022
35,118,351
Hesitancy towards a COVID-19 vaccine among midwives in Turkey during the COVID-19 pandemic: A cross-sectional web-based survey.
European journal of midwifery
Eur J Midwifery
6
null
10.18332/ejm/143874
eng
2,022
null
null
2,022
1
26
[INTRODUCTION] One of the most significant barriers to social immunization, which is critical in combating the COVID-19 pandemic, is vaccine hesitancy or rejection. The purpose of this study was to determine the acceptance, hesitancy and barriers to COVID-19 vaccines among midwives in Turkey. [METHODS] A total of 806 m...
COVID-19; midwives; vaccine acceptance; vaccine hesitancy
0.362
13
Maternity and Midwifery; Obstetrics and Gynecology; Pediatrics, Perinatology and Child Health
Medicine; Nursing
2,022
35,117,854
The antitumor effect of miR-448 in epithelial ovarian cancer.
Translational cancer research
Transl Cancer Res
9
8
10.21037/tcr-20-2464
eng
2,020
8
null
null
null
null
[BACKGROUND] Ovarian cancer (OC) is the seventh most commonly diagnosed cancer in the world and the tenth most common in China. Target agents such as bevacizumab and poly (ADP-ribose) polymerase (PARP) inhibitors show efficacy only in the early stages of some cases; therefore, more effective molecular targeting agents ...
Ovarian cancer (OC); cellular proliferation; miR-448; zinc finger E-box-binding homeobox 2 (ZEB2)
0.254
43
Cancer Research; Oncology; Radiology, Nuclear Medicine and Imaging
Biochemistry, Genetics and Molecular Biology; Medicine
2,020
35,141,580
Osteoporotic burst fracture-clinical, radiological and functional outcome of three-column reconstruction using single posterior approach (Instrumentation, Corpectomy, Arthroscope Assisted Transpedicular Decompression and Mesh Cage).
North American Spine Society journal
N Am Spine Soc J
1
null
10.1016/j.xnsj.2020.100009
eng
2,020
5
null
2,020
5
29
[PURPOSE] To evaluate a novel effective procedure utilizing three-column reconstruction via a posterior approach with a technique that utilizes an arthroscope to visualize the anterior surface of the dura during decompression. [METHODS] A Prospective Study. 80 Osteoporotic vertebral burst fracture patients with similar...
Arthroscope Assisted Transpedicular decompression; Mesh CageIntroduction; Osteoporotic fracture; Posterior approach; three-column reconstruction
null
null
null
null
null
35,172,309
The Socio-Demographics and Health Service Use of Opioid Overdose Decedents in Wales: A Cross-Sectional Data Linkage Study.
European addiction research
Eur Addict Res
28
3
10.1159/000521614
eng
2,022
null
null
2,022
2
16
[BACKGROUND] Fatal opioid overdose is a significant public health problem with increasing incidence in developed countries. This study aimed to describe demographic and service user characteristics of decedents of opioid overdose in Wales to identify possible targets for behaviour modification and life-saving intervent...
Emergency department; Epidemiology; Opioids; Overdose
1.114
64
Health; Medicine; Psychiatry and Mental Health
Medicine; Social Sciences
2,022
35,172,264
Serum molecular biomarkers in neuromyelitis optica and multiple sclerosis.
Multiple sclerosis and related disorders
Mult Scler Relat Disord
59
null
10.1016/j.msard.2022.103527
eng
2,022
3
null
2,022
1
20
[BACKGROUND] Neuromyelitis optica spectrum disorder (NMOSD) is a rare and severe inflammatory demyelinating disorder of the central nervous system (CNS), which mainly affects the optic nerves and spinal cord. The aims of this study were to determine whether the expression levels of serological cytokines could distingui...
AQP4; EGF; IL-17B; MS; NMOSD
0.92
70
Medicine; Neurology; Neurology
Medicine; Neuroscience
2,022
35,171,982
Associations Among Daily Living Skills, Motor, and Sensory Difficulties in Autistic and Nonautistic Children.
The American journal of occupational therapy : official publication of the American Occupational Therapy Association
Am J Occup Ther
76
2
10.5014/ajot.2022.045955
eng
2,022
3
1
null
null
null
[IMPORTANCE] Motor and sensory challenges are commonly reported among autistic individuals and have been linked to challenges with daily living skills (DLS). To best inform clinical intervention, greater specificity in how sensory and motor challenges relate to DLS is needed. [OBJECTIVE] To evaluate the relationship be...
null
null
null
null
null
null
35,171,700
Validating Automatic Diadochokinesis Analysis Methods Across Dysarthria Severity and Syllable Task in Amyotrophic Lateral Sclerosis.
Journal of speech, language, and hearing research : JSLHR
J Speech Lang Hear Res
65
3
10.1044/2021_JSLHR-21-00503
eng
2,022
3
8
2,022
2
16
[PURPOSE] Oral diadochokinesis (DDK) is a standard dysarthria assessment task. To extract automatic and semi-automatic DDK measurements, numerous DDK analysis algorithms based on acoustic signal processing are available, including amplitude based, spectral based, and hybrid. However, these algorithms have been predomin...
null
0.867
164
Linguistics and Language; Speech and Hearing; Medicine
Health Professions; Medicine; Social Sciences
2,022
35,171,365
Altered levels of circulating CD8[+]CXCR5[+]PD-1[+]T follicular cytotoxic cells in primary Sjögren's syndrome.
Clinical rheumatology
Clin Rheumatol
41
6
10.1007/s10067-022-06098-y
eng
2,022
6
null
2,022
2
16
[BACKGROUND] Circulating CD8[+] T-cells expressing the C-X-C chemokine receptor type 5 (CXCR5) (CD8[+]CXCR5[+]T), a recently identified follicular cytotoxic T cell subset, are involved in antiviral immunity and autoimmunity, but their abundance and role in the pathogenesis of primary Sjögren syndrome (pSS) are unknown....
CD8+ regulatory T cells; CD8+CXCR5+ follicular cytotoxic T subsets; Lung involvement; OPLS-DA
0.864
104
Medicine; Rheumatology
Medicine
2,022
35,171,348
Identification of pathology-confirmed vulnerable atherosclerotic lesions by coronary computed tomography angiography using radiomics analysis.
European radiology
Eur Radiol
32
6
10.1007/s00330-021-08518-0
eng
2,022
6
null
2,022
2
16
[OBJECTIVES] To explore whether radiomics-based machine learning (ML) models could outperform conventional diagnostic methods at identifying vulnerable lesions on coronary computed tomographic angiography (CCTA). [METHODS] In this retrospective study, 36 heart transplant recipients with coronary heart disease (CAD) and...
Atherosclerosis; Computed tomography angiography; Coronary artery disease; Machine learning; Pathology
1.733
182
Medicine; Radiology, Nuclear Medicine and Imaging
Medicine
2,022
35,171,203
Association Between Short-term Exposure to Environmental Air Pollution and Psoriasis Flare.
JAMA dermatology
JAMA Dermatol
158
4
10.1001/jamadermatol.2021.6019
eng
2,022
4
1
null
null
null
[IMPORTANCE] Psoriasis is a chronic inflammatory disease with a relapsing-remitting course. Selected environmental factors such as infections, stressful life events, or drugs may trigger disease flares. Whether air pollution could trigger psoriasis flares is still unknown. [OBJECTIVE] To investigate whether short-term ...
null
null
null
null
null
null
35,170,835
Epigenetic conditioning induces intergenerational resilience to dementia in a mouse model of vascular cognitive impairment.
Alzheimer's & dementia : the journal of the Alzheimer's Association
Alzheimers Dement
18
10
10.1002/alz.12616
eng
2,022
10
null
2,022
2
16
[INTRODUCTION] Epigenetic stimuli induce beneficial or detrimental changes in gene expression, and consequently, phenotype. Some of these phenotypes can manifest across the lifespan-and even in subsequent generations. Here, we used a mouse model of vascular cognitive impairment and dementia (VCID) to determine whether ...
chronic cerebral hypoperfusion; epigenetics; hypoxic conditioning; intergenerational; resilience; vascular cognitive impairment and dementia
null
null
null
null
null
35,170,775
Utilization and in-hospital complications of catheter ablation for atrial fibrillation in patients with obesity and morbid obesity.
Clinical cardiology
Clin Cardiol
45
4
10.1002/clc.23795
eng
2,022
4
null
2,022
2
16
[BACKGROUND] Real-world data on atrial fibrillation (AF) ablation outcomes in obese populations have remained scarce, especially the relationship between obesity and in-hospital AF ablation outcome. [HYPOTHESIS] Obesity is associated with higher complication rates and higher admission trend for AF ablation. [METHODS] W...
ablation; atrial fibrillation; complications; obesity
0.806
89
Cardiology and Cardiovascular Medicine; Medicine
Medicine
2,022
35,170,531
Somatosensory assessments in patients with inflammatory bowel disease: a cross-sectional study examining pain processing pathways and the role of multiple patient factors.
European journal of gastroenterology & hepatology
Eur J Gastroenterol Hepatol
34
5
10.1097/MEG.0000000000002354
eng
2,022
5
1
null
null
null
[BACKGROUND] Pain affects the majority of patients with inflammatory bowel disease (IBD), where pain experiences may be influenced by multiple patient factors and changes within central pain processing pathways, termed central sensitization. The current study aimed to investigate pain processing pathways in patients wi...
null
null
null
null
null
null
35,170,501
Outcomes of Telehealth for Wound Care: A Scoping Review.
Advances in skin & wound care
Adv Skin Wound Care
35
7
10.1097/01.ASW.0000821916.26355.fa
eng
2,022
7
1
2,022
2
14
[OBJECTIVE] To synthesize the literature on delivering wound care via telehealth and compare clinical, healthcare utilization, and cost outcomes when wound care is provided via telehealth (telewound) modalities compared with in-person care. [DATA SOURCES] An electronic search of PubMed, CINAHL, and Cochrane Clinical Tr...
null
null
null
null
null
null
35,170,192
Effect of bremelanotide on body weight of obese women: Data from two phase 1 randomized controlled trials.
Diabetes, obesity & metabolism
Diabetes Obes Metab
24
6
10.1111/dom.14672
eng
2,022
6
null
2,022
3
15
[AIMS] The melanocortin 4 receptor (MC4R) plays a central role in appetite regulation, and agonistic activity at this receptor promotes satiety. Results from two randomized controlled clinical trials examine the effects of bremelanotide's agonism at MC4R on caloric intake and body weight. [METHODS] Premenopausal women ...
MC4r agonist; bremelanotide; melanocortin; obesity; weight loss
null
null
null
null
null
35,170,083
Ultrasonographic patterns, clinical findings, and prognostic variables in dogs from Asia with gallbladder mucocele.
Journal of veterinary internal medicine
J Vet Intern Med
36
2
10.1111/jvim.16384
eng
2,022
3
null
2,022
2
15
[BACKGROUND] Gallbladder mucocele (GBM) is a common biliary disorder in dogs that can be categorized into 6 types, but the value of this classification scheme remains unknown. Cholecystectomy is associated with high death rates and warrants additional interrogation. [OBJECTIVES] Investigate the clinical value of ultras...
biliary; blood pressure; canine; cholecystectomy; hypotension; survival
1.171
130
Medicine; Veterinary
Medicine; Veterinary
2,022
35,169,959
Role of Surfactants on Release Performance of Amorphous Solid Dispersions of Ritonavir and Copovidone.
Pharmaceutical research
Pharm Res
39
2
10.1007/s11095-022-03183-4
eng
2,022
2
null
2,022
2
15
[PURPOSE] To understand the role of different surfactants, incorporated into amorphous solid dispersions (ASDs) of ritonavir and copovidone, in terms of their impact on release, phase behavior and stabilization of amorphous precipitates formed following drug release. [METHODS] Ternary ASDs with ritonavir, copovidone an...
amorphous solid dispersion; droplets; release; surfactant
0.644
235
Biotechnology; Organic Chemistry; Pharmaceutical Science; Pharmacology; Pharmacology; Molecular Medicine
Biochemistry, Genetics and Molecular Biology; Chemistry; Medicine; Pharmacology, Toxicology and Pharmaceutics
2,022
35,169,693
Availability of the core components of the World Health Organization infection prevention and control strategies in health facilities in Southwestern Uganda: Implications for control of COVID-19.
Infection prevention in practice
Infect Prev Pract
4
2
10.1016/j.infpip.2022.100206
eng
2,022
6
null
2,022
2
10
[BACKGROUND] Infection prevention and control (IPC) practices are required to prevent nosocomial infection by severe acute respiratory syndrome coronavirus 2. In low- and middle-income countries, where resources are often limited, IPC practices are infrequently assessed. [AIM] To assess the availability of the core com...
Africa; COVID-19; Infection prevention and control; Uganda
0.544
16
Public Health, Environmental and Occupational Health; Infectious Diseases
Medicine
2,022
35,168,463
Comparing the use of mathematical calculation to a measuring wheel to determine distance walked in three different course configurations of the 6 minute Walk Test in healthy adults.
Annals of medicine
Ann Med
54
1
10.1080/07853890.2022.2041209
eng
2,022
12
null
null
null
null
[INTRODUCTION] A recent clinical practice guideline set forth recommendations for the administration of the 6 Minute Walk Test, including course set-up and using mathematical calculation to obtain the distance walked. In clinical practice and research, however, deviations from these protocols exist. [PURPOSE] To assess...
Walking capacity; gait; outcome measures; walking test
1.052
133
Medicine
Medicine
2,022
35,167,911
Orthohepevirus C infection as an emerging cause of acute hepatitis in Spain: First report in Europe.
Journal of hepatology
J Hepatol
77
2
10.1016/j.jhep.2022.01.028
eng
2,022
8
null
2,022
2
12
[BACKGROUND AND AIM] Hepatitis E virus (HEV) was considered the only member of the Hepeviridae family with zoonotic potential. Nevertheless, this consideration has been reassessed owing to several reported cases of acute and chronic hepatitis linked to the Orthohepevirus C genus. Because the circulation of Orthohepevir...
Hepatitis E; Orthohepevirus C; acute hepatitis; rodent; zoonosis
7.398
319
Hepatology
Medicine
2,022
35,167,597
Rationales and functions of disliked music: An in-depth interview study.
PloS one
PLoS One
17
2
10.1371/journal.pone.0263384
eng
2,022
null
null
2,022
2
15
[BACKGROUND AND OBJECTIVES] With a few exceptions, musical taste has been researched via likes or preferences of certain types of music. The present study focuses on disliked music and takes a broad approach to cover explanatory strategies related to personal dislikes. [METHODS] In-depth interviews were conducted with ...
null
0.885
467
Multidisciplinary
Multidisciplinary
2,022
35,167,125
Quality of life, psychological distress, and prognostic perceptions in patients with multiple myeloma.
Cancer
Cancer
128
10
10.1002/cncr.34134
eng
2,022
5
15
2,022
2
15
[BACKGROUND] Multiple myeloma (MM) is an incurable hematologic malignancy requiring long-term, continuous therapy. Despite its chronic and unrelenting course, studies examining quality of life (QOL), psychological distress, and perceptions of prognosis by line of therapy are lacking. [METHODS] The authors conducted a c...
multiple myeloma; perceptions of prognosis; psychological distress; quality of life; supportive care
2.736
349
Cancer Research; Oncology
Biochemistry, Genetics and Molecular Biology; Medicine
2,022
35,166,716
Surgical Reduction of Chronic Bilateral Traumatic Dislocation of the Mandibular Condyles With Erosion of the Middle Fossa Floor: Case Report With Surgical Video.
Operative neurosurgery (Hagerstown, Md.)
Oper Neurosurg
22
3
10.1227/ONS.0000000000000048
eng
2,022
3
1
null
null
null
[BACKGROUND] Dislocation of the mandibular condyle (MC) is not a common condition, but when a traumatic case involves erosion of the middle fossa floor, it becomes a much more complicated and even rarer pathology. [OBJECTIVE] To describe the management of traumatic dislocation of the MCs with erosion of the middle foss...
null
0.502
44
Surgery; Neurology
Medicine
2,022
35,166,648
Temporal context effects and energy drink consumption: the moderating role of behavioral status.
Journal of American college health : J of ACH
J Am Coll Health
72
1
10.1080/07448481.2022.2032087
eng
2,024
1
null
2,022
2
15
[OBJECTIVE] This study investigated the factors that impact the effectiveness of energy drink-related health messages. Specifically, this study examined how behavioral status moderates the effects of the temporal contexts described in messages related to energy drink consumption. [PARTICIPANTS] A total of 823 college s...
attitudes; behavioral status; descriptive norms; perceived behavioral control; subjective norms; temporal context
1.028
117
Public Health, Environmental and Occupational Health
Medicine
2,024