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In healthcare, a differential diagnosis (DDx) is a method of analysis that distinguishes a particular disease or condition from others that present with similar clinical features. Differential diagnostic procedures are used by clinicians to diagnose the specific disease in a patient, or, at least, to consider any immin... | Wikipedia/Differential_diagnosis |
A non-communicable disease (NCD) is a disease that is not transmissible directly from one person to another. NCDs include Parkinson's disease, autoimmune diseases, strokes, heart diseases, cancers, diabetes, chronic kidney disease, osteoarthritis, osteoporosis, Alzheimer's disease, cataracts, and others. NCDs may be ch... | Wikipedia/Non-infectious_disease |
A male genital disease is a condition that affects the male reproductive system. The human male genitals consist of testicles and epididymides, ductus deferentes, seminal vesicles and ejaculatory ducts, prostate, bulbourethral glands, and penis.
== Classification by type of disease ==
=== Infection ===
==== Aetio... | Wikipedia/Male_genital_disease |
Disseminated disease can refer to disseminated cancer which is the movement of cancerous cells from the original tumor to other areas of the body, or disseminated infection which is the pathogen's entry into the host, growth, and dissemination, which results in illness.
After exiting the main tumor, cancer cells circul... | Wikipedia/Disseminated_disease |
Airborne transmission or aerosol transmission is transmission of an infectious disease through small particles suspended in the air. Infectious diseases capable of airborne transmission include many of considerable importance both in human and veterinary medicine. The relevant infectious agent may be viruses, bacteria,... | Wikipedia/Airborne_disease |
Endocrine diseases are disorders of the endocrine system. The branch of medicine associated with endocrine disorders is known as endocrinology. Interconnected
== Types of disease ==
Broadly speaking, endocrine disorders may be subdivided into three groups:
Endocrine gland hypofunction/hyposecretion (leading to hormo... | Wikipedia/Endocrine_disease |
Maternal–fetal medicine (MFM), also known as perinatology, is a branch of medicine that focuses on managing health concerns of the mother and fetus prior to, during, and shortly after pregnancy.
Maternal–fetal medicine specialists are physicians who subspecialize within the field of obstetrics. Their training typically... | Wikipedia/Fetal_disease |
There are several scoring systems in intensive care units (ICUs) today.
== Adult scoring systems ==
APACHE II was designed to provide a morbidity score for a patient. It is useful to decide what kind of treatment or medicine is given. Methods exist to derive a predicted mortality from this score, but these methods ar... | Wikipedia/ICU_scoring_systems |
Hematologic diseases are disorders which primarily affect the blood and blood-forming organs. Hematologic diseases include rare genetic disorders, anemia, HIV, sickle cell disease and complications from chemotherapy or transfusions.
== Myeloid ==
Hemoglobinopathies (congenital abnormality of the hemoglobin molecule o... | Wikipedia/Hematologic_disease |
Lifestyle diseases can be defined as the diseases linked to the manner in which a person lives their life. These diseases are non-communicable, and can be caused by lack of physical activity, unhealthy eating, alcohol, substance use disorders and smoking tobacco, which can lead to heart disease, stroke, obesity, type ... | Wikipedia/Lifestyle_disease |
A systemic disease is one that affects a number of organs and tissues, or affects the body as a whole. It differs from a localized disease, which is a disease affecting only part of the body (e.g., a mouth ulcer).
== Examples ==
Mastocytosis, including mast cell activation syndrome and eosinophilic esophagitis
Chron... | Wikipedia/Systemic_disease |
Disease burden is the impact of a health problem as measured by financial cost, mortality, morbidity, or other indicators. It is often quantified in terms of quality-adjusted life years (QALYs) or disability-adjusted life years (DALYs). Both of these metrics quantify the number of years lost due to disability (YLDs), s... | Wikipedia/Disease_burden |
An infection is the invasion of tissues by pathogens, their multiplication, and the reaction of host tissues to the infectious agent and the toxins they produce. An infectious disease, also known as a transmissible disease or communicable disease, is an illness resulting from an infection.
Infections can be caused by a... | Wikipedia/Communicable_disease |
A chronic condition (also known as chronic disease or chronic illness) is a health condition or disease that is persistent or otherwise long-lasting in its effects or a disease that comes with time. The term chronic is often applied when the course of the disease lasts for more than three months.
Common chronic disease... | Wikipedia/Chronic_diseases |
A genetic disorder is a health problem caused by one or more abnormalities in the genome. It can be caused by a mutation in a single gene (monogenic) or multiple genes (polygenic) or by a chromosome abnormality. Although polygenic disorders are the most common, the term is mostly used when discussing disorders with a s... | Wikipedia/Hereditary_disease |
Geographic information science (GIScience, GISc) or geoinformation science is a scientific discipline at the crossroads of computational science, social science, and natural science that studies geographic information, including how it represents phenomena in the real world, how it represents the way humans understand ... | Wikipedia/Geographic_Information_Science |
Lymphatic disease is a class of disorders which directly affect the components of the lymphatic system.
Examples include Castleman's disease and lymphedema.
== Types ==
Diseases and disorder
Hodgkin's Disease/Hodgkin's Lymphoma
Hodgkin lymphoma This is a type of cancer of the lymphatic system. It can start almost any... | Wikipedia/Lymphatic_disease |
Progressive disease or progressive illness is a disease or physical ailment whose course in most cases is the worsening, growth, or spread of the disease. This may happen until death, serious debility, or organ failure occurs. Some progressive diseases can be halted and reversed by treatment (surgical, dietary, or life... | Wikipedia/Progressive_disease |
An idiopathic disease is any disease with an unknown cause or mechanism of apparent spontaneous origin.
For some medical conditions, one or more causes are somewhat understood, but in a certain percentage of people with the condition, the cause may not be readily apparent or characterized. In these cases, the origin ... | Wikipedia/Idiopathic_disease |
A sexually transmitted infection (STI), also referred to as a sexually transmitted disease (STD) and the older term venereal disease (VD), is an infection that is spread by sexual activity, especially vaginal intercourse, anal sex, oral sex, or sometimes manual sex. STIs often do not initially cause symptoms, which res... | Wikipedia/Sexually_transmitted_disease |
Mitochondrial disease is a group of disorders caused by mitochondrial dysfunction. Mitochondria are the organelles that generate energy for the cell and are found in every cell of the human body except red blood cells. They convert the energy of food molecules into the ATP that powers most cell functions.
Mitochondrial... | Wikipedia/Mitochondrial_disease |
Connective tissue diseases (also termed connective tissue disorders, or collagen vascular diseases), are medical conditions that affect connective tissue.
Connective tissues protect, support, and provide structure for the body's other tissues and structures. They hold the body's structures together. Connective tissues... | Wikipedia/Connective_tissue_disease |
Urologic diseases or conditions include urinary tract infections, kidney stones, bladder control problems, and prostate problems, among others. Some urologic conditions do not affect a person for that long and some are lifetime conditions. Kidney diseases are normally investigated and treated by nephrologists, while th... | Wikipedia/Urologic_disease |
Breast diseases make up a number of conditions. The most common symptoms are a breast mass, breast pain, and nipple discharge.
A majority of breast diseases are noncancerous.
Although breast disease may be benign, or non-life threatening there remains an associated risk with potentially a higher risk of developing brea... | Wikipedia/Breast_disease |
This is a partial list of human eye diseases and disorders.
The World Health Organization (WHO) publishes a classification of known diseases and injuries, the International Statistical Classification of Diseases and Related Health Problems, or ICD-10. This list uses that classification.
== H00-H06 Disorders of eyeli... | Wikipedia/Eye_disease |
In medicine, describing a disease as acute denotes that it is of recent onset; it occasionally denotes a short duration. The quantification of how much time constitutes "short" and "recent" varies by disease and by context, but the core denotation of "acute" is always qualitatively in contrast with "chronic", which den... | Wikipedia/Acute_disease |
The Autobots are a fictional faction of sentient robots in the Transformers multimedia franchise. The Autobots are living robots from the planet Cybertron who, like most Transformers, are each imbued with a unique "life force" known as a "spark." Led by Optimus Prime in most stories, the Autobots believe that "freedom ... | Wikipedia/Flareup_(Transformers) |
Cerebrovascular disease includes a variety of medical conditions that affect the blood vessels of the brain and the cerebral circulation. Arteries supplying oxygen and nutrients to the brain are often damaged or deformed in these disorders. The most common presentation of cerebrovascular disease is an ischemic stroke o... | Wikipedia/Cerebrovascular_disease |
A contagious disease is an infectious disease that can be spread rapidly in several ways, including direct contact, indirect contact, and droplet contact.
These diseases are caused by organisms such as parasites, bacteria, fungi, and viruses. While many types of organisms live on the human body and are usually harmles... | Wikipedia/Contagious_disease |
Otology is a branch of medicine which studies normal, pathological anatomy and physiology of the ear (hearing). Otology also studies vestibular sensory systems, related structures and functions, as well as their diseases, diagnosis and treatment. Otologic surgery generally refers to surgery of the middle ear and mastoi... | Wikipedia/Ear_disease |
Malnutrition occurs when an organism gets too few or too many nutrients, resulting in health problems. Specifically, it is a deficiency, excess, or imbalance of energy, protein and other nutrients which adversely affects the body's tissues and form.
Malnutrition is a category of diseases that includes undernutrition an... | Wikipedia/Deficiency_disease |
A medical condition is a broad term that includes all diseases and disorders.
A disease is an abnormal condition affecting the body of an organism.
A disorder is a functional abnormality or disturbance.
Lists of animal diseases
List of autoimmune diseases
List of cancer types
List of childhood diseases and disorders
L... | Wikipedia/Lists_of_diseases |
Diseases of affluence, previously called diseases of rich people, is a term sometimes given to selected diseases and other health conditions which are commonly thought to be a result of increasing wealth in a society. Also referred to as the "Western disease" paradigm, these diseases are in contrast to "diseases of pov... | Wikipedia/Diseases_of_affluence |
Respiratory diseases, or lung diseases, are pathological conditions affecting the organs and tissues that make gas exchange difficult in air-breathing animals. They include conditions of the respiratory tract including the trachea, bronchi, bronchioles, alveoli, pleurae, pleural cavity, the nerves and muscles of respi... | Wikipedia/Respiratory_disease |
Asymptomatic (or clinically silent) is an adjective categorising the medical conditions (i.e., injuries or diseases) that patients carry but without experiencing their symptoms, despite an explicit diagnosis (e.g., a positive medical test).
Pre-symptomatic is the adjective categorising the time periods during which the... | Wikipedia/Subclinical |
Functional disorders are a group of recognisable medical conditions which are due to changes to the functioning of the systems of the body rather than due to a disease affecting the structure of the body.
Functional disorders are common and complex phenomena that pose challenges to medical systems. Traditionally in med... | Wikipedia/Functional_disorder |
An infection is the invasion of tissues by pathogens, their multiplication, and the reaction of host tissues to the infectious agent and the toxins they produce. An infectious disease, also known as a transmissible disease or communicable disease, is an illness resulting from an infection.
Infections can be caused by a... | Wikipedia/Infectious_disease |
Metastasis is a pathogenic agent's spreading from an initial or primary site to a different or secondary site within the host's body; the term is typically used when referring to metastasis by a cancerous tumor. The newly pathological sites, then, are metastases (mets). It is generally distinguished from cancer invasi... | Wikipedia/Metastatic_disease |
A localized disease is an infectious or neoplastic process that originates in and is confined to one organ system or general area in the body, such as a sprained ankle, a boil on the hand, an abscess of finger.
A localized cancer that has not extended beyond the margins of the organ involved can also be described as lo... | Wikipedia/Localized_disease |
Terminal illness or end-stage disease is a disease that cannot be cured or adequately treated and is expected to result in the death of the patient. This term is more commonly used for progressive diseases such as cancer, rather than fatal injury. In popular use, it indicates a disease that will progress until death wi... | Wikipedia/Terminal_disease |
Your Disease Risk is a publicly available health risk assessment tool on the Internet. Launched in early 2000 and continually updated, the site offers risk assessments for twelve different cancers and four other important chronic diseases: heart disease, stroke, diabetes, and osteoporosis.
The site began in 1998 as a ... | Wikipedia/Your_Disease_Risk |
Anti-citrullinated protein antibodies (ACPAs) are autoantibodies (antibodies to an individual's own proteins) that are directed against peptides and proteins that are citrullinated. They are present in the majority of patients with rheumatoid arthritis. Clinically, cyclic citrullinated peptides (CCP) are frequently use... | Wikipedia/Anti–citrullinated_protein_antibody |
Anti-glycoprotein-210 antibodies (AGPA, anti-gp210, anti-nup210, anti-np210) are directed at gp210 and are found within primary biliary cirrhosis (PBC) patients in high frequency. AGPA recognize the cytoplasmic-oriented carboxyl terminus (tail) of the protein. While AGPA is found as a prognostic marker in only a minori... | Wikipedia/Anti-glycoprotein-210_antibodies |
Coeliac disease (British English) or celiac disease (American English) is a long-term autoimmune disorder, primarily affecting the small intestine. Patients develop intolerance to gluten, which is present in foods such as wheat, rye, spelt and barley. Classic symptoms include gastrointestinal problems such as chronic ... | Wikipedia/Coeliac_disease |
FORCE11 is an international coalition of researchers, librarians, publishers and research funders working to reform or enhance the research publishing and communication system. Initiated in 2011 as a community of interest on scholarly communication, FORCE11 is a registered 501(c)(3) organization based in the United Sta... | Wikipedia/FORCE11 |
Hemolytic disease of the newborn, also known as hemolytic disease of the fetus and newborn, HDN, HDFN, or erythroblastosis fetalis, is an alloimmune condition that develops in a fetus at or around birth, when the IgG molecules (one of the five main types of antibodies) produced by the mother pass through the placenta. ... | Wikipedia/Hemolytic_disease_of_the_newborn |
An immune complex, sometimes called an antigen-antibody complex or antigen-bound antibody, is a molecule formed from the binding of multiple antigens to antibodies. The bound antigen and antibody act as a unitary object, effectively an antigen of its own with a specific epitope. After an antigen-antibody reaction, the ... | Wikipedia/Antigen-antibody_complex |
Extracellular matrix protein 1 is a protein that in humans is encoded by the ECM1 gene.
This gene encodes an extracellular protein containing motifs with a cysteine pattern characteristic of the cysteine pattern of the ligand-binding "double-loop" domains of the albumin protein family. This gene maps outside the epider... | Wikipedia/Extracellular_matrix_protein_1 |
A heavy-chain antibody is an antibody which consists only of two heavy chains and lacks the two light chains usually found in antibodies.
In common antibodies, the antigen binding region consists of the variable domains of the heavy and light chains (VH and VL). Heavy-chain antibodies can bind antigens despite having o... | Wikipedia/Heavy-chain_antibody |
Retinol-binding proteins (RBP) are a family of proteins with diverse functions. They are carrier proteins that bind retinol. Assessment of retinol-binding protein is used to determine visceral protein mass in health-related nutritional studies.
Retinol and retinoic acid play crucial roles in the modulation of gene expr... | Wikipedia/Retinol_binding_protein |
Plasma proteins, sometimes referred to as blood proteins, are proteins present in blood plasma. They perform many different functions, including transport of hormones, vitamins and minerals in activity and functioning of the immune system. Other blood proteins act as enzymes, complement, components, protease inhibitors... | Wikipedia/Blood_proteins |
Protein A/G is a recombinant fusion protein that combines IgG binding domains of both protein A and protein G. Protein A/G contains four Fc binding domains from protein A and two from protein G, yielding a final mass of 50,460 daltons. The binding of protein A/G is less pH-dependent than protein A, but otherwise has th... | Wikipedia/Protein_A/G |
Anti-mitochondrial antibodies (AMA) are autoantibodies, consisting of immunoglobulins formed against mitochondria, primarily the mitochondria in cells of the liver.
The presence of AMA in the blood or serum of a person may be indicative of the presence of, or the potential to develop, the autoimmune disease primary bil... | Wikipedia/Anti-mitochondrial_antibody |
Synthetic antibodies are affinity reagents generated entirely in vitro, thus completely eliminating animals from the production process. Synthetic antibodies include recombinant antibodies, nucleic acid aptamers and non-immunoglobulin protein scaffolds. As a consequence of their in vitro manufacturing method the antige... | Wikipedia/Synthetic_antibody |
A trifunctional antibody is a monoclonal antibody with binding sites for two different antigens, typically CD3 and a tumor antigen, making it a type of bispecific monoclonal antibody. In addition, its intact Fc-part can bind to an Fc receptor on accessory cells like conventional monospecific antibodies. The net effect ... | Wikipedia/Trifunctional_antibody |
A neutralizing antibody (NAb) is an antibody that defends a cell from a pathogen or infectious particle by neutralizing any effect it has biologically. Neutralization renders the particle no longer infectious or pathogenic.
Neutralizing antibodies are part of the humoral response of the adaptive immune system against ... | Wikipedia/Neutralizing_antibody |
Antithyroid autoantibodies (or simply antithyroid antibodies) are autoantibodies targeted against one or more components on the thyroid. The most clinically relevant anti-thyroid autoantibodies are anti-thyroid peroxidase antibodies (anti-TPO antibodies, TPOAb), thyrotropin receptor antibodies (TRAb) and thyroglobulin ... | Wikipedia/Anti-thyroid_peroxidase_antibody |
Anti-double stranded DNA (Anti-dsDNA) antibodies are a group of anti-nuclear antibodies (ANA) the target antigen of which is double stranded DNA. Blood tests such as enzyme-linked immunosorbent assay (ELISA) and immunofluorescence are routinely performed to detect anti-dsDNA antibodies in diagnostic laboratories. They ... | Wikipedia/Anti-dsDNA |
Antibody mimetics are organic compounds that, like antibodies, can specifically bind antigens, but that are not structurally related to antibodies. They are usually artificial peptides or proteins with a molar mass of about 3 to 20 kDa. (Antibodies are ~150 kDa.)
Nucleic acids and small molecules are sometimes consider... | Wikipedia/Antibody_mimetic |
Alcoholic liver disease (ALD), also called alcohol-related liver disease (ARLD), is a term that encompasses the liver manifestations of alcohol overconsumption, including fatty liver, alcoholic hepatitis, and chronic hepatitis with liver fibrosis or cirrhosis.
It is the major cause of liver disease in Western countries... | Wikipedia/Alcoholic_liver_disease |
In autoimmune disease, anti-apolipoprotein H (AAHA) antibodies, also called anti-β2 glycoprotein I antibodies, comprise a subset of anti-cardiolipin antibodies and lupus anticoagulant. These antibodies are involved in sclerosis and are strongly associated with thrombotic forms of lupus. As a result, AAHA are strongly i... | Wikipedia/Anti-apolipoprotein_antibodies |
Bence Jones protein is a monoclonal globulin protein or immunoglobulin light chain found in the urine, with a molecular weight of 22–24 kDa. Detection of Bence Jones protein may be suggestive of multiple myeloma, or Waldenström's macroglobulinemia.
Bence Jones proteins are particularly diagnostic of multiple myeloma ... | Wikipedia/Bence-Jones_protein |
Antibody-dependent cellular cytotoxicity (ADCC), also referred to as antibody-dependent cell-mediated cytotoxicity, is a mechanism of cell-mediated immune defense whereby an effector cell of the immune system kills a target cell, whose membrane-surface antigens have been bound by specific antibodies. It is one of the m... | Wikipedia/Antibody-dependent_cell-mediated_cytotoxicity |
Serum protein electrophoresis (SPEP or SPE) is a laboratory test that examines specific proteins in the blood called globulins. The most common indications for a serum protein electrophoresis test are to diagnose or monitor multiple myeloma, a monoclonal gammopathy of uncertain significance (MGUS), or further investiga... | Wikipedia/Serum_protein_electrophoresis |
Rh disease (also known as rhesus isoimmunization, Rh (D) disease, or rhesus incompatibility, and blue baby disease) is a type of hemolytic disease of the fetus and newborn (HDFN). The term "Rh disease" is commonly used to refer to HDFN due to anti-D antibodies (the D antigen being only one of more than 50 in the Rh com... | Wikipedia/Rh_disease |
An autoantibody is an antibody (a type of protein) produced by the immune system that is directed against one or more of the individual's own proteins. Many autoimmune diseases (notably lupus erythematosus) are associated with such antibodies.
== Production ==
Antibodies are produced by B cells in two ways: (i) rando... | Wikipedia/Autoantibody |
The side-chain theory (German, Seitenkettentheorie) is a theory proposed by Paul Ehrlich (1854–1915) to explain the immune response in living cells. Ehrlich theorized from very early in his career that chemical structure could be used to explain why the immune response occurred in reaction to infection. He believed tha... | Wikipedia/Side-chain_theory |
A monoclonal antibody (mAb, more rarely called moAb) is an antibody produced from a cell lineage made by cloning a unique white blood cell. All subsequent antibodies derived this way trace back to a unique parent cell.
Monoclonal antibodies are identical and can thus have monovalent affinity, binding only to a particul... | Wikipedia/Monoclonal_antibody |
Immunology is a branch of biology and medicine that covers the study of immune systems in all organisms.
Immunology charts, measures, and contextualizes the physiological functioning of the immune system in states of both health and diseases; malfunctions of the immune system in immunological disorders (such as autoimm... | Wikipedia/Clinical_immunology |
Protein primary structure is the linear sequence of amino acids in a peptide or protein. By convention, the primary structure of a protein is reported starting from the amino-terminal (N) end to the carboxyl-terminal (C) end. Protein biosynthesis is most commonly performed by ribosomes in cells. Peptides can also be sy... | Wikipedia/Protein_sequences |
In drug development, preclinical development (also termed preclinical studies or nonclinical studies) is a stage of research that begins before clinical trials (testing in humans) and during which important feasibility, iterative testing and drug safety data are collected, typically in laboratory animals.
The main goa... | Wikipedia/Preclinical |
A single-domain antibody (sdAb), also known as a Nanobody, is an antibody fragment consisting of a single monomeric variable antibody domain. Like a whole antibody, it is able to bind selectively to a specific antigen. With a molecular weight of only 12–15 kDa, single-domain antibodies (sdAbs) are much smaller than com... | Wikipedia/Single-domain_antibody |
A microantibody is an artificial short chain of amino acids copied from a fully functional natural antibody. Microantibodies can stop viruses such as HIV from infecting cells in vitro.
Antibodies are produced naturally by the body and play a key role in fighting infections caused by bacteria and viruses. They can also ... | Wikipedia/Microantibody |
Anti-neutrophil cytoplasmic antibodies (ANCAs) are a group of autoantibodies, mainly of the IgG type, against antigens in the cytoplasm of neutrophils (the most common type of white blood cell) and monocytes. They are detected as a blood test in a number of autoimmune disorders, but are particularly associated with sys... | Wikipedia/Anti-neutrophil_cytoplasmic_antibody |
Antinuclear antibodies (ANAs, also known as antinuclear factor or ANF) are autoantibodies that bind to contents of the cell nucleus. In normal individuals, the immune system produces antibodies to foreign proteins (antigens) but not to human proteins (autoantigens). In some cases, antibodies to human antigens are produ... | Wikipedia/Anti-nuclear_antibody |
The immune network theory is a theory of how the adaptive immune system works, that has been developed since 1974 mainly by Niels Jerne and Geoffrey W. Hoffmann. The theory states that the immune system is an interacting network of lymphocytes and molecules that have variable (V) regions. These V regions bind not only ... | Wikipedia/Immune_network_theory |
A tetrameric protein is a protein with a quaternary structure of four subunits (tetrameric). Homotetramers have four identical subunits (such as glutathione S-transferase), and heterotetramers are complexes of different subunits. A tetramer can be assembled as dimer of dimers with two homodimer subunits (such as sorbit... | Wikipedia/Tetramer_protein |
Vitamin D-binding protein (DBP), also/originally known as gc-globulin (group-specific component), is a protein that in humans is encoded by the GC gene. DBP is genetically the oldest member of the albuminoid family and appeared early in the evolution of vertebrates.
== Structure ==
Human GC is a glycosylated alpha-gl... | Wikipedia/Vitamin_D-binding_protein |
Carbohydrate–protein interactions are the intermolecular and intramolecular interactions between protein and carbohydrate moieties. These interactions form the basis of specific recognition of carbohydrates by lectins. Carbohydrates are important biopolymers and have a variety of functions. Often carbohydrates serve a ... | Wikipedia/Protein–carbohydrate_interaction |
Protein sequencing is the practical process of determining the amino acid sequence of all or part of a protein or peptide. This may serve to identify the protein or characterize its post-translational modifications. Typically, partial sequencing of a protein provides sufficient information (one or more sequence tags) t... | Wikipedia/Protein_sequencing |
Dirigent proteins are members of a class of proteins which dictate the stereochemistry of a compound synthesized by other enzymes. The first dirigent protein was discovered in Forsythia intermedia. This protein has been found to direct the stereoselective biosynthesis of (+)-pinoresinol from coniferyl alcohol monomers:... | Wikipedia/Dirigent_protein |
Glycan-Protein interactions represent a class of biomolecular interactions that occur between free or protein-bound glycans and their cognate binding partners. Intramolecular glycan-protein (protein-glycan) interactions occur between glycans and proteins that they are covalently attached to. Together with protein-prote... | Wikipedia/Glycan-protein_interactions |
Protein targeting or protein sorting is the biological mechanism by which proteins are transported to their appropriate destinations within or outside the cell. Proteins can be targeted to the inner space of an organelle, different intracellular membranes, the plasma membrane, or to the exterior of the cell via secreti... | Wikipedia/Protein_translocation |
In biochemistry, globular proteins or spheroproteins are spherical ("globe-like") proteins and are one of the common protein types (the others being fibrous, disordered and membrane proteins). Globular proteins are somewhat water-soluble (forming colloids in water), unlike the fibrous or membrane proteins. There are mu... | Wikipedia/Globular_proteins |
Protein quinary structure refers to the features of protein surfaces that are shaped by evolutionary adaptation to the physiological context of living cells. Quinary structure is thus the fifth level of protein complexity, additional to protein primary, secondary, tertiary and quaternary structures. As opposed to the f... | Wikipedia/Protein_quinary_structure |
Motor proteins are a class of molecular motors that can move along the cytoskeleton of cells. They do this by converting chemical energy into mechanical work by the hydrolysis of ATP.
== Cellular functions ==
Motor proteins are the driving force behind most active transport of proteins and vesicles in the cytoplasm... | Wikipedia/Motor_protein |
Protein structure is the three-dimensional arrangement of atoms in an amino acid-chain molecule. Proteins are polymers – specifically polypeptides – formed from sequences of amino acids, which are the monomers of the polymer. A single amino acid monomer may also be called a residue, which indicates a repeating unit ... | Wikipedia/Protein_conformation |
The Bradford protein assay (also known as the Coomassie protein assay) was developed by Marion M. Bradford in 1976. It is a quick and accurate spectroscopic analytical procedure used to measure the concentration of protein in a solution. The reaction is dependent on the amino acid composition of the measured proteins.
... | Wikipedia/Bradford_protein_assay |
A protein microarray (or protein chip) is a high-throughput method used to track the interactions and activities of proteins, and to determine their function, and determining function on a large scale. Its main advantage lies in the fact that large numbers of proteins can be tracked in parallel. The chip consists of a ... | Wikipedia/Protein_microarray |
The hierarchical equations of motion (HEOM) technique derived by Yoshitaka Tanimura and Ryogo Kubo in 1989, is a non-perturbative approach developed to study the evolution of a density matrix
ρ
(
t
)
{\displaystyle \rho (t)}
of quantum dissipative syst... | Wikipedia/Hierarchical_equations_of_motion |
Homology modeling, also known as comparative modeling of protein, refers to constructing an atomic-resolution model of the "target" protein from its amino acid sequence and an experimental three-dimensional structure of a related homologous protein (the "template"). Homology modeling relies on the identification of one... | Wikipedia/Homology_modeling |
Protein electrophoresis is a method for analysing the proteins in a fluid or an extract. The electrophoresis may be performed with a small volume of sample in a number of alternative ways with or without a supporting medium, namely agarose or polyacrylamide. Variants of gel electrophoresis include SDS-PAGE, free-flow e... | Wikipedia/Gel_electrophoresis_of_proteins |
Protein toxicity is the effect of the buildup of protein metabolic waste compounds, like urea, uric acid, ammonia, and creatinine. Protein toxicity has many causes, including urea cycle disorders, genetic mutations, excessive protein intake, and insufficient kidney function, such as chronic kidney disease and acute kid... | Wikipedia/Protein_toxicity |
ENA/VASP homology proteins or EVH proteins are a family of closely related proteins involved in cell motility in vertebrate and invertebrate animals. EVH proteins are modular proteins that are involved in actin polymerization, as well as interactions with other proteins. Within the cell, ENA/VASP proteins are found at ... | Wikipedia/Ena/Vasp_homology_proteins |
In cell biology, protein turnover refers to the replacement of older proteins as they are broken down within the cell. Different types of proteins have very different turnover rates.
A balance between protein synthesis and protein degradation is required for good health and normal protein metabolism. More synthesis tha... | Wikipedia/Protein_turnover |
In thermodynamics, the thermodynamic free energy is one of the state functions of a thermodynamic system. The change in the free energy is the maximum amount of work that the system can perform in a process at constant temperature, and its sign indicates whether the process is thermodynamically favorable or forbidden. ... | Wikipedia/Free_energy_(thermodynamics) |
DNA-binding proteins are proteins that have DNA-binding domains and thus have a specific or general affinity for single- or double-stranded DNA. Sequence-specific DNA-binding proteins generally interact with the major groove of B-DNA, because it exposes more functional groups that identify a base pair.
== Examples ==... | Wikipedia/Protein–DNA_interaction |
Protein–lipid interaction is the influence of membrane proteins on the lipid physical state or vice versa.
The questions which are relevant to understanding of the structure and function of the membrane are: 1) Do intrinsic membrane proteins bind tightly to lipids (see annular lipid shell), and what is the nature of th... | Wikipedia/Protein–lipid_interaction |
A transmembrane protein is a type of integral membrane protein that spans the entirety of the cell membrane. Many transmembrane proteins function as gateways to permit the transport of specific substances across the membrane. They frequently undergo significant conformational changes to move a substance through the mem... | Wikipedia/Transmembrane_protein |
Materials that are used for biomedical or clinical applications are known as biomaterials. The following article deals with fifth generation biomaterials that are used for bone structure replacement. For any material to be classified for biomedical applications, three requirements must be met. The first requirement is ... | Wikipedia/Mechanical_properties_of_biomaterials |
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