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A DNA-binding domain (DBD) is an independently folded protein domain that contains at least one structural motif that recognizes double- or single-stranded DNA. A DBD can recognize a specific DNA sequence (a recognition sequence) or have a general affinity to DNA. Some DNA-binding domains may also include nucleic acid... | Wikipedia/DNA-binding_domain |
Protein tyrosine phosphatases (EC 3.1.3.48, systematic name protein-tyrosine-phosphate phosphohydrolase) are a group of enzymes that remove phosphate groups from phosphorylated tyrosine residues on proteins:
[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate
Protein tyrosine (pTyr) phosphorylation... | Wikipedia/Protein_tyrosine_phosphatase |
In molecular biology, fibrous proteins or scleroproteins are one of the three main classifications of protein structure (alongside globular and membrane proteins). Fibrous proteins are made up of elongated or fibrous polypeptide chains which form filamentous and sheet-like structures. This kind of protein can be distin... | Wikipedia/Scleroprotein |
Sickle cell disease (SCD), also simply called sickle cell, is a group of inherited haemoglobin-related blood disorders. The most common type is known as sickle cell anemia. Sickle cell anemia results in an abnormality in the oxygen-carrying protein haemoglobin found in red blood cells. This leads to the red blood cells... | Wikipedia/Sickle_cell_disease |
Translational neuroscience is the field of study which applies neuroscience research to translate or develop into clinical applications and novel therapies for nervous system disorders. The field encompasses areas such as deep brain stimulation, brain machine interfaces, neurorehabilitation and the development of devic... | Wikipedia/Translational_neuroscience |
Biological neuron models, also known as spiking neuron models, are mathematical descriptions of the conduction of electrical signals in neurons. Neurons (or nerve cells) are electrically excitable cells within the nervous system, able to fire electric signals, called action potentials, across a neural network. These m... | Wikipedia/Biological_neuron_model |
The British Neuroscience Association (BNA) is a scientific society with around 2,500 members. Starting out as an informal gathering of scientists meeting at the Black Horse Public House in London to discuss brain-related topics (the 'London Black Horse Group'), on 23 February 1968 it was formerly established as the Bra... | Wikipedia/British_Neuroscience_Association |
Cellular neuroscience is a branch of neuroscience concerned with the study of neurons at a cellular level. This includes morphology and physiological properties of single neurons. Several techniques such as intracellular recording, patch-clamp, and voltage-clamp technique, pharmacology, confocal imaging, molecular biol... | Wikipedia/Cellular_neuroscience |
The Morris–Lecar model is a biological neuron model developed by Catherine Morris and Harold Lecar to reproduce the variety of oscillatory behavior in relation to Ca++ and K+ conductance in the muscle fiber of the giant barnacle . Morris–Lecar neurons exhibit both class I and class II neuron excitability.
== History ... | Wikipedia/Morris–Lecar_model |
The FitzHugh–Nagumo model (FHN) describes a prototype of an excitable system (e.g., a neuron).
It is an example of a relaxation oscillator because, if the external stimulus
I
ext
{\displaystyle I_{\text{ext}}}
exceeds a ce... | Wikipedia/FitzHugh–Nagumo_model |
A motor neuron (or motoneuron), also known as efferent neuron is a neuron whose cell body is located in the motor cortex, brainstem or the spinal cord, and whose axon (fiber) projects to the spinal cord or outside of the spinal cord to directly or indirectly control effector organs, mainly muscles and glands. There ar... | Wikipedia/Motor_neuron |
Sensory neuroscience is a subfield of neuroscience which explores the anatomy and physiology of neurons that are part of sensory systems such as vision, hearing, and olfaction. Neurons in sensory regions of the brain respond to stimuli by firing one or more nerve impulses (action potentials) following stimulus presenta... | Wikipedia/Sensory_neuroscience |
In neuroscience, functional specialization is a theory which suggests that different areas in the brain are specialized for different functions. It is opposed to the anti-localizationist theories and brain holism and equipotentialism.
== Historical origins ==
Phrenology, created by Franz Joseph Gall (1758–1828) and ... | Wikipedia/Functional_specialization_(brain) |
Integrative neuroscience is the study of neuroscience that works to unify functional organization data to better understand complex structures and behaviors. The relationship between structure and function, and how the regions and functions connect to each other. Different parts of the brain carrying out different task... | Wikipedia/Integrative_neuroscience |
Neuroscience is the scientific study of the nervous system (the brain, spinal cord, and peripheral nervous system), its functions, and its disorders. It is a multidisciplinary science that combines physiology, anatomy, molecular biology, developmental biology, cytology, psychology, physics, computer science, chemistry,... | Wikipedia/Brain_science |
Nutritional neuroscience is the scientific discipline that studies the effects various components of the diet such as minerals, vitamins, protein, carbohydrates, fats, dietary supplements, synthetic hormones, and food additives have on neurochemistry, neurobiology, behavior, and cognition.
Research on nutritional mecha... | Wikipedia/Nutritional_neuroscience |
Principles of Neural Science is a neuroscience textbook edited by Columbia University professors Eric R. Kandel, James H. Schwartz, and Thomas M. Jessell. First published in 1981 by McGraw-Hill, the original edition was 468 pages, and has now grown to 1646 pages on the sixth edition. The second edition was published in... | Wikipedia/Principles_of_Neural_Science |
Global neurosurgery is a field at the intersection of public health and clinical neurosurgery. It aims to expand provision of improved and equitable neurosurgical care globally.
== Definition and history ==
Global neurosurgery is "the clinical and public health practice of neurosurgery with the primary purpose of ens... | Wikipedia/Global_neurosurgery |
Large-scale brain networks (also known as intrinsic brain networks) are collections of widespread brain regions showing functional connectivity by statistical analysis of the fMRI BOLD signal or other recording methods such as EEG, PET and MEG. An emerging paradigm in neuroscience is that cognitive tasks are performed ... | Wikipedia/Large-scale_brain_network |
Molecular neuroscience is a branch of neuroscience that observes concepts in molecular biology applied to the nervous systems of animals. The scope of this subject covers topics such as molecular neuroanatomy, mechanisms of molecular signaling in the nervous system, the effects of genetics and epigenetics on neuronal d... | Wikipedia/Molecular_neuroscience |
The neuron doctrine is the concept that the nervous system is made up of discrete individual cells, a discovery due to decisive neuro-anatomical work of Santiago Ramón y Cajal and later presented by, among others, H. Waldeyer-Hartz. The term neuron (spelled neurone in British English) was itself coined by Waldeyer as a... | Wikipedia/Neuron_doctrine |
Biomedical sciences are a set of sciences applying portions of natural science or formal science, or both, to develop knowledge, interventions, or technology that are of use in healthcare or public health. Such disciplines as medical microbiology, clinical virology, clinical epidemiology, genetic epidemiology, and bio... | Wikipedia/Biomedical_sciences |
I of the Vortex: From Neurons to Self is a popular science book by the Colombian neuroscientist Rodolfo Llinás, published in February 2002 by MIT Press. and whose Spanish edition features a prologue by his friend, Nobel laureate Gabriel García Márquez.
The book is considered a best seller for scientific dissemination a... | Wikipedia/I_of_the_vortex:_from_neurons_to_self |
Biological neuron models, also known as spiking neuron models, are mathematical descriptions of the conduction of electrical signals in neurons. Neurons (or nerve cells) are electrically excitable cells within the nervous system, able to fire electric signals, called action potentials, across a neural network. These m... | Wikipedia/Biological_neuron_models |
A mathematical model is an abstract description of a concrete system using mathematical concepts and language. The process of developing a mathematical model is termed mathematical modeling. Mathematical models are used in applied mathematics and in the natural sciences (such as physics, biology, earth science, chemis... | Wikipedia/Mathematical_Modeling |
Neurosurgery or neurological surgery, known in common parlance as brain surgery, is the medical specialty that focuses on the surgical treatment or rehabilitation of disorders which affect any portion of the nervous system including the brain, spinal cord, peripheral nervous system, and cerebrovascular system. Neurosur... | Wikipedia/Neurosurgery |
The development of the nervous system, or neural development (neurodevelopment), refers to the processes that generate, shape, and reshape the nervous system of animals, from the earliest stages of embryonic development to adulthood. The field of neural development draws on both neuroscience and developmental biology ... | Wikipedia/Neuronal_migration |
A neural network, also called a neuronal network, is an interconnected population of neurons (typically containing multiple neural circuits). Biological neural networks are studied to understand the organization and functioning of nervous systems.
Closely related are artificial neural networks, machine learning models ... | Wikipedia/Neural_network_(biology) |
Neurotherapy is medical treatment that implements systemic targeted delivery of an energy stimulus or chemical agents to a specific neurological zone in the body to alter neuronal activity and stimulate neuroplasticity in a way that develops (or balances) a nervous system in order to treat different diseases, restore a... | Wikipedia/Neurotherapy |
Psychosurgery, also called neurosurgery for mental disorder (NMD), is the neurosurgical treatment of mental disorders. Psychosurgery has always been a controversial medical field. The modern history of psychosurgery begins in the 1880s under the Swiss psychiatrist Gottlieb Burckhardt. The first significant foray into ... | Wikipedia/Psychosurgery |
Neuroscience is a peer-reviewed scientific journal of neuroscience. It was established in 1976 with P.G. Kostyuk, Rodolfo Llinás, and A.D. Smith as founding editors-in-chief and originally published by Pergamon Press. The current editor-in-chief is Juan Lerma Gómez (Spanish National Research Council). The journal is pu... | Wikipedia/Neuroscience_(journal) |
Cultural neuroscience is a field of research that focuses on the interrelation between a human's cultural environment and neurobiological systems. The field particularly incorporates ideas and perspectives from related domains like anthropology, psychology, and cognitive neuroscience to study sociocultural influences o... | Wikipedia/Cultural_neuroscience |
A neurodegenerative disease is caused by the progressive loss of neurons, in the process known as neurodegeneration. Neuronal damage may also ultimately result in their death. Neurodegenerative diseases include amyotrophic lateral sclerosis, multiple sclerosis, Parkinson's disease, Alzheimer's disease, Huntington's dis... | Wikipedia/Neurodegenerative_disease |
The Hodgkin–Huxley model, or conductance-based model, is a mathematical model that describes how action potentials in neurons are initiated and propagated. It is a set of nonlinear differential equations that approximates the electrical engineering characteristics of excitable cells such as neurons and muscle cells. It... | Wikipedia/Hodgkin–Huxley_model |
A clinical research associate (CRA), also called a clinical monitor or trial monitor, is a health-care professional who performs many activities related to medical research, particularly clinical trials. Clinical research associates work in various settings, such as pharmaceutical companies, medical research institutes... | Wikipedia/Clinical_research_associate |
A neural network, also called a neuronal network, is an interconnected population of neurons (typically containing multiple neural circuits). Biological neural networks are studied to understand the organization and functioning of nervous systems.
Closely related are artificial neural networks, machine learning models ... | Wikipedia/Neural_networks_(biology) |
Computational neurogenetic modeling (CNGM) is concerned with the study and development of dynamic neuronal models for modeling brain functions with respect to genes and dynamic interactions between genes. These include neural network models and their integration with gene network models. This area brings together knowl... | Wikipedia/Computational_neurogenetic_modeling |
Consumer neuroscience is the combination of consumer research with modern neuroscience. The goal of the field is to find neural explanations for consumer behaviors in individuals both with or without disease.
== Consumer research ==
Consumer research has existed for more than a century and has been well established ... | Wikipedia/Consumer_neuroscience |
The neuroscience of religion, also known as "neurotheology" or "spiritual neuroscience," seeks to explain the biological and neurological processes behind religious experience. Researchers in this field study correlations of the biological neural phenomena, in addition to subjective experiences of spirituality, in orde... | Wikipedia/Neuroscience_of_religion |
Clinical neuroscience is a branch of neuroscience that focuses on the scientific study of fundamental mechanisms that underlie diseases and disorders of the brain and central nervous system. It seeks to develop new ways of conceptualizing and diagnosing such disorders and ultimately of developing novel treatments.
A c... | Wikipedia/Clinical_neuroscience |
Models of neural computation are attempts to elucidate, in an abstract and mathematical fashion, the core principles that underlie information processing in biological nervous systems, or functional components thereof. This article aims to provide an overview of the most definitive models of neuro-biological computatio... | Wikipedia/Models_of_neural_computation |
Nanoneuroscience is an interdisciplinary field that integrates nanotechnology and neuroscience. One of its main goals is to gain a detailed understanding of how the nervous system operates and, thus, how neurons organize themselves in the brain. Consequently, creating drugs and devices that are able to cross the blood ... | Wikipedia/Nanoneuroscience |
Functional neuroimaging is the use of neuroimaging technology to measure an aspect of brain function, often with a view to understanding the relationship between activity in certain brain areas and specific mental functions. It is primarily used as a research tool in cognitive neuroscience, cognitive psychology, neurop... | Wikipedia/Functional_neuroimaging |
The development of the nervous system, or neural development (neurodevelopment), refers to the processes that generate, shape, and reshape the nervous system of animals, from the earliest stages of embryonic development to adulthood. The field of neural development draws on both neuroscience and developmental biology ... | Wikipedia/Developmental_neuroscience |
Golgi's method is a silver staining technique that is used to visualize nervous tissue under light microscopy. The method was discovered by Camillo Golgi, an Italian physician and scientist, who published the first picture made with the technique in 1873. It was initially named the black reaction (la reazione nera) by... | Wikipedia/Golgi's_method |
Magnetoencephalography (MEG) is a functional neuroimaging technique for mapping brain activity by recording magnetic fields produced by electrical currents occurring naturally in the brain, using very sensitive magnetometers. Arrays of SQUIDs (superconducting quantum interference devices) are currently the most common ... | Wikipedia/Magnetoencephalography |
Hydrolyzed vegetable protein (HVP) products are foodstuffs obtained by the hydrolysis of protein, and have a meaty, savory taste similar to broth (bouillon).
Regarding the production process, a distinction can be made between acid-hydrolyzed vegetable protein (aHVP), enzymatically produced HVP, and other seasonings, e.... | Wikipedia/Acid-hydrolyzed_vegetable_protein |
The Food Information and Control Agency (Spanish: Agencia de Información y Control Alimentarios, AICA), known between 1988 and 2014 as the Olive Oil Agency, is the Spanish Department of Agriculture, Fisheries and Food autonomous agency responsible for managing the information and control systems of the olericulture, da... | Wikipedia/Food_Information_and_Control_Agency |
Nutritional rating systems are used to communicate the nutritional value of food in a more-simplified manner, with a ranking (or rating), than nutrition facts labels. A system may be targeted at a specific audience. Rating systems have been developed by governments, non-profit organizations, private institutions, and c... | Wikipedia/Nutritional_rating_systems |
Minamata disease (Japanese: 水俣病, Hepburn: Minamata-byō) is a neurological disease caused by severe mercury poisoning. Signs and symptoms include ataxia, numbness in the hands and feet, general muscle weakness, loss of peripheral vision, and damage to hearing and speech. In extreme cases, insanity, paralysis, coma, and ... | Wikipedia/Minamata_disease |
A parasitic disease, also known as parasitosis, is an infectious disease caused by parasites. Parasites are organisms which derive sustenance from its host while causing it harm. The study of parasites and parasitic diseases is known as parasitology. Medical parasitology is concerned with three major groups of parasite... | Wikipedia/Parasitic_disease |
Variant Creutzfeldt–Jakob disease (vCJD), formerly known as new variant Creutzfeldt–Jakob disease (nvCJD) and referred to colloquially as "mad cow disease" or "human mad cow disease" to distinguish it from its BSE counterpart, is a fatal type of brain disease within the transmissible spongiform encephalopathy family. I... | Wikipedia/Variant_Creutzfeldt–Jakob_disease |
Clinical nutrition centers on the prevention, diagnosis, and management of nutritional changes in patients linked to chronic diseases and conditions primarily in health care. Clinical in this sense refers to the management of patients, including not only outpatients at clinics and in private practice, but also inpatien... | Wikipedia/Clinical_nutrition |
3-Phosphoglyceric acid (3PG, 3-PGA, or PGA) is the conjugate acid of 3-phosphoglycerate or glycerate 3-phosphate (GP or G3P). This glycerate is a biochemically significant metabolic intermediate in both glycolysis and the Calvin-Benson cycle. The anion is often termed as PGA when referring to the Calvin-Benson cycle. ... | Wikipedia/3-Phosphoglycerate |
Bisphosphoglycerate mutase (EC 5.4.2.4, BPGM) is an enzyme expressed in erythrocytes and placental cells. It is responsible for the catalytic synthesis of 2,3-Bisphosphoglycerate (2,3-BPG) from 1,3-bisphosphoglycerate. BPGM has both a mutase and a phosphatase function, but these are much less active, in contrast to i... | Wikipedia/Bisphosphoglycerate_mutase |
Phosphoglycerate mutase 2 (PGAM2), also known as muscle-specific phosphoglycerate mutase (PGAM-M), is a phosphoglycerate mutase that, in humans, is encoded by the PGAM2 gene on chromosome 7.
Phosphoglycerate mutase (PGAM) catalyzes the reversible reaction of 3-phosphoglycerate (3-PGA) to 2-phosphoglycerate (2-PGA) in t... | Wikipedia/Glycogen_storage_disease_type_X |
2,3-Bisphosphoglyceric acid (conjugate base 2,3-bisphosphoglycerate) (2,3-BPG), also known as 2,3-diphosphoglyceric acid (conjugate base 2,3-diphosphoglycerate) (2,3-DPG), is a three-carbon isomer of the glycolytic intermediate 1,3-bisphosphoglyceric acid (1,3-BPG).
D-2,3-BPG is present in human red blood cells (RBC; e... | Wikipedia/2,3-Bisphosphoglycerate |
E3 binding protein also known as pyruvate dehydrogenase protein X component, mitochondrial is a protein that in humans is encoded by the PDHX gene. The E3 binding protein is a component of the pyruvate dehydrogenase complex found only in eukaryotes. Defects in this gene are a cause of pyruvate dehydrogenase deficiency ... | Wikipedia/E3_binding_protein |
2,3-Bisphosphoglyceric acid (conjugate base 2,3-bisphosphoglycerate) (2,3-BPG), also known as 2,3-diphosphoglyceric acid (conjugate base 2,3-diphosphoglycerate) (2,3-DPG), is a three-carbon isomer of the glycolytic intermediate 1,3-bisphosphoglyceric acid (1,3-BPG).
D-2,3-BPG is present in human red blood cells (RBC; e... | Wikipedia/2,3-bisphosphoglycerate |
The biochemical systems equation is a compact equation of nonlinear differential equations for describing a kinetic model for any network of coupled biochemical reactions and transport processes.
The equation is expressed in the following form:
... | Wikipedia/Biochemical_systems_equation |
Cancer systems biology encompasses the application of systems biology approaches to cancer research, in order to study the disease as a complex adaptive system with emerging properties at multiple biological scales. Cancer systems biology represents the application of systems biology approaches to the analysis of how t... | Wikipedia/Cancer_systems_biology |
Functional genomics is a field of molecular biology that attempts to describe gene (and protein) functions and interactions. Functional genomics make use of the vast data generated by genomic and transcriptomic projects (such as genome sequencing projects and RNA sequencing). Functional genomics focuses on the dynamic... | Wikipedia/Functional_genomics |
In biochemistry, metabolic control analysis (MCA) is a mathematical framework for describing
metabolic, signaling, and genetic pathways. MCA quantifies how variables, such as fluxes and species concentrations, depend on network parameters.
In particular, it is able to describe how network-dependent properties,
called ... | Wikipedia/Metabolic_Control_Analysis |
BioSystems is a monthly peer-reviewed scientific journal covering experimental, computational, and theoretical research that links biology, evolution, and the information processing sciences. It was established in 1967 as Currents in Modern Biology by Robert G. Grenell and published by North-Holland Publishing Company ... | Wikipedia/BioSystems |
Drug design, often referred to as rational drug design or simply rational design, is the inventive process of finding new medications based on the knowledge of a biological target. The drug is most commonly an organic small molecule that activates or inhibits the function of a biomolecule such as a protein, which in tu... | Wikipedia/Structure-based_drug_design |
Neural coding (or neural representation) is a neuroscience field concerned with characterising the hypothetical relationship between the stimulus and the neuronal responses, and the relationship among the electrical activities of the neurons in the ensemble. Based on the theory that
sensory and other information is rep... | Wikipedia/Neuroelectrodynamics |
Metabolic network modelling, also known as metabolic network reconstruction or metabolic pathway analysis, allows for an in-depth insight into the molecular mechanisms of a particular organism. In particular, these models correlate the genome with molecular physiology. A reconstruction breaks down metabolic pathways (s... | Wikipedia/Metabolic_network_modelling |
Computer simulation is the running of a mathematical model on a computer, the model being designed to represent the behaviour of, or the outcome of, a real-world or physical system. The reliability of some mathematical models can be determined by comparing their results to the real-world outcomes they aim to predict. C... | Wikipedia/Computational_modeling |
DNA polymerase I (or Pol I) is an enzyme that participates in the process of prokaryotic DNA replication. Discovered by Arthur Kornberg in 1956, it was the first known DNA polymerase (and the first known of any kind of polymerase). It was initially characterized in E. coli and is ubiquitous in prokaryotes. In E. coli ... | Wikipedia/DNA_polymerase_I |
Phosphoglycerate kinase (EC 2.7.2.3) (PGK 1) is an enzyme that catalyzes the reversible transfer of a phosphate group from 1,3-bisphosphoglycerate (1,3-BPG) to ADP producing 3-phosphoglycerate (3-PG) and ATP :
1,3-bisphosphoglycerate + ADP ⇌ glycerate 3-phosphate + ATP
Like all kinases it is a transferase. PGK is a ma... | Wikipedia/Phosphoglycerate_kinase_deficiency |
DNA polymerase eta (Pol η), is a protein that in humans is encoded by the POLH gene.
DNA polymerase eta is a eukaryotic DNA polymerase involved in the DNA repair by translesion synthesis. The gene encoding DNA polymerase eta is POLH, also known as XPV, because loss of this gene results in the disease xeroderma pigmento... | Wikipedia/DNA_polymerase_eta |
DNA polymerase lambda, also known as Pol λ, is an enzyme found in all eukaryotes. In humans, it is encoded by the POLL gene.
== Function ==
Pol λ is a member of the X family of DNA polymerases. It is thought to resynthesize missing nucleotides during non-homologous end joining (NHEJ), a pathway of DNA double-strand ... | Wikipedia/DNA_polymerase_lambda |
DNA Polymerase V (Pol V) is a polymerase enzyme involved in DNA repair mechanisms in bacteria, such as Escherichia coli. It is composed of a UmuD' homodimer and a UmuC monomer, forming the UmuD'2C protein complex. It is part of the Y-family of DNA Polymerases, which are capable of performing DNA translesion synthesis (... | Wikipedia/DNA_polymerase_V |
DNA polymerase epsilon is a member of the DNA polymerase family of enzymes found in eukaryotes. It is composed of the following four subunits: POLE (central catalytic unit), POLE2 (subunit 2), POLE3 (subunit 3), and POLE4 (subunit 4). Recent evidence suggests that it plays a major role in leading strand DNA synthesis... | Wikipedia/DNA_polymerase_epsilon |
DNA polymerase III holoenzyme is the primary enzyme complex involved in prokaryotic DNA replication. It was discovered by Thomas Kornberg (son of Arthur Kornberg) and Malcolm Gefter in 1970. The complex has high processivity (i.e. the number of nucleotides added per binding event) and, specifically referring to the rep... | Wikipedia/DNA_polymerase_III_holoenzyme |
In enzymology, a protein-histidine pros-kinase (EC 2.7.13.1) is an enzyme that catalyzes the chemical reaction
ATP + protein L-histidine
⇌
{\displaystyle \rightleftharpoons }
ADP + protein Nπ-phospho-L-histidine
Thus, the two substrates of this enzyme are ATP and protein L-h... | Wikipedia/Protein-histidine_pros-kinase |
Cell Biochemistry and Biophysics is a peer-reviewed scientific journal covering all aspects of the biology of cells, especially their biochemistry and biophysics. It was established in 1979 as Cell Biophysics with Nicholas Catsimpoolas as founding editor-in-chief, obtaining its current name in 1996. The journal is publ... | Wikipedia/Cell_Biochemistry_and_Biophysics |
A serine/threonine protein kinase (EC 2.7.11.-) is a kinase enzyme, in particular a protein kinase, that phosphorylates the OH group of the amino-acid residues serine or threonine, which have similar side chains. At least 350 of the 500+ human protein kinases are serine/threonine kinases (STK).
In enzymology, the term... | Wikipedia/Serine/threonine-specific_protein_kinase |
DNA polymerase mu is a polymerase enzyme found in eukaryotes. In humans, this protein is encoded by the POLM gene.
== Function ==
Pol μ is a member of the X family of DNA polymerases. It participates in resynthesis of damaged or missing nucleotides during the non-homologous end joining (NHEJ) pathway of DNA repair. ... | Wikipedia/DNA_polymerase_mu |
1,3-Bisphosphoglyceric acid (1,3-Bisphosphoglycerate or 1,3BPG) is a 3-carbon organic molecule present in most, if not all, living organisms. It primarily exists as a metabolic intermediate in both glycolysis during respiration and the Calvin cycle during photosynthesis. 1,3BPG is a transitional stage between glycerate... | Wikipedia/1,3-Bisphosphoglycerate |
DNA polymerase IV is a prokaryotic polymerase that is involved in mutagenesis and is encoded by the dinB gene. It exhibits no 3′→5′ exonuclease (proofreading) activity and hence is error prone. In E. coli, DNA polymerase IV (Pol 4) is involved in non-targeted mutagenesis. Pol IV is a Family Y polymerase expressed by th... | Wikipedia/DNA_polymerase_IV |
A protein kinase is a kinase which selectively modifies other proteins by covalently adding phosphates to them (phosphorylation) as opposed to kinases which modify lipids, carbohydrates, or other molecules. Phosphorylation usually results in a functional change of the target protein (substrate) by changing enzyme activ... | Wikipedia/Protein_kinase |
DNA polymerase delta (DNA Pol δ) is an enzyme complex found in eukaryotes that is involved in DNA replication and repair. The DNA polymerase delta complex consists of 4 subunits: POLD1, POLD2, POLD3, and POLD4. DNA Pol δ is an enzyme used for both leading and lagging strand synthesis. It exhibits increased processivity... | Wikipedia/DNA_polymerase_delta |
DNA polymerase alpha also known as Pol α is an enzyme complex found in eukaryotes that is involved in initiation of DNA replication. The DNA polymerase alpha complex consists of 4 subunits: POLA1, POLA2, PRIM1, and PRIM2.
Pol α has limited processivity and lacks 3′ exonuclease activity for proofreading errors. Thus it ... | Wikipedia/DNA_polymerase_alpha |
In enzymology, a protein-histidine tele-kinase (EC 2.7.13.2) is an enzyme that catalyzes the chemical reaction
ATP + protein L-histidine
⇌
{\displaystyle \rightleftharpoons }
ADP + protein Nτ-phospho-L-histidine
Thus, the two substrates of this enzyme are ATP and protein L-h... | Wikipedia/Protein-histidine_tele-kinase |
DNA polymerase II (also known as DNA Pol II or Pol II) is a prokaryotic DNA-dependent DNA polymerase encoded by the PolB gene.
DNA Polymerase II is an 89.9-kDa protein and is a member of the B family of DNA polymerases. It was originally isolated by Thomas Kornberg in 1970, and characterized over the next few years. Th... | Wikipedia/DNA_polymerase_II |
DNA polymerase beta, also known as POLB, is an enzyme present in eukaryotes. In humans, it is encoded by the POLB gene.
== Function ==
In eukaryotic cells, DNA polymerase beta (POLB) performs base excision repair (BER) required for DNA maintenance, replication, recombination, and drug resistance.
The mitochondrial DN... | Wikipedia/DNA_polymerase_beta |
T7 DNA polymerase is an enzyme used during the DNA replication of the T7 bacteriophage. During this process, the DNA polymerase “reads” existing DNA strands and creates two new strands that match the existing ones. The T7 DNA polymerase requires a host factor, E. coli thioredoxin, in order to carry out its function. Th... | Wikipedia/T7_DNA_polymerase |
Pfu DNA polymerase is an enzyme found in the hyperthermophilic archaeon Pyrococcus furiosus, where it functions to copy the organism's DNA during cell division (thermostable DNA polymerase). In the laboratory setting, Pfu is used to amplify DNA in the polymerase chain reaction (PCR), where the enzyme serves the central... | Wikipedia/Pfu_DNA_polymerase |
The management of HIV/AIDS normally includes the use of multiple antiretroviral drugs as a strategy to control HIV infection. There are several classes of antiretroviral agents that act on different stages of the HIV life-cycle. The use of multiple drugs that act on different viral targets is known as highly active ant... | Wikipedia/Antiretroviral_drugs |
Agnatha (; from Ancient Greek ἀ- (a-) 'without' and γνάθος (gnáthos) 'jaws') or jawless fish is a paraphyletic infraphylum of animals in the subphylum Vertebrata of the phylum Chordata, characterized by the lack of jaws. The group consists of both living (cyclostomes such as hagfishes and lampreys) and extinct clades... | Wikipedia/Jawless_vertebrates |
Marine vertebrates are vertebrates that live in marine environments, which include saltwater fish (including pelagic, coral and deep sea fish) and marine tetrapods (primarily marine mammals and marine reptiles, as well as semiaquatic clades such as seabirds). As a subphylum of chordates, all vertebrates have evolved a ... | Wikipedia/Marine_vertebrate |
Gnathostomata (; from Ancient Greek: γνάθος (gnathos) 'jaw' + στόμα (stoma) 'mouth') are jawed vertebrates. Gnathostome diversity comprises roughly 60,000 species, which accounts for 99% of all extant vertebrates, including all living bony fishes (both ray-finned and lobe-finned, including their terrestrial tetrapod re... | Wikipedia/Jawed_vertebrate |
The taxonomy of the vertebrates presented by John Zachary Young in The Life of Vertebrates (1962) is a system of classification with emphasis on this group of animals.
== Phylum Chordata ==
Phylum Chordata [p. 24]
Subphylum 1. Hemichordata (e.g., Balanoglossus, Cephalodiscus, Rhabdopleura)
Subphylum 2. Cephalochordat... | Wikipedia/Taxonomy_of_the_vertebrates_(Young,_1962) |
Invertebrates are animals that neither develop nor retain a vertebral column (commonly known as a spine or backbone), which evolved from the notochord. It is a paraphyletic grouping including all animals excluding the chordate subphylum Vertebrata, i.e. vertebrates. Well-known phyla of invertebrates include arthropods,... | Wikipedia/Invertebrate |
Gnathostomata (; from Ancient Greek: γνάθος (gnathos) 'jaw' + στόμα (stoma) 'mouth') are jawed vertebrates. Gnathostome diversity comprises roughly 60,000 species, which accounts for 99% of all extant vertebrates, including all living bony fishes (both ray-finned and lobe-finned, including their terrestrial tetrapod re... | Wikipedia/Jawed_vertebrates |
The Integrated Taxonomic Information System (ITIS) is an American partnership of federal agencies designed to provide consistent and reliable information on the taxonomy of biological species. ITIS was originally formed in 1996 as an interagency group within the US federal government, involving several US federal agenc... | Wikipedia/Integrated_Taxonomic_Information_System |
In biochemistry, non-coded or non-proteinogenic amino acids are distinct from the 22 proteinogenic amino acids (21 in eukaryotes), which are naturally encoded in the genome of organisms for the assembly of proteins. However, over 140 non-proteinogenic amino acids occur naturally in proteins and thousands more may occur... | Wikipedia/Non-proteinogenic_amino_acids |
In computational biology, protein pKa calculations are used to estimate the pKa values of amino acids as they exist within proteins. These calculations complement the pKa values reported for amino acids in their free state, and are used frequently within the fields of molecular modeling, structural bioinformatics, and ... | Wikipedia/Protein_pKa_calculations |
In chemistry, the rate equation (also known as the rate law or empirical differential rate equation) is an empirical differential mathematical expression for the reaction rate of a given reaction in terms of concentrations of chemical species and constant parameters (normally rate coefficients and partial orders of rea... | Wikipedia/Rate_law |
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