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pair_32865370 | Decompression and curettage can result are effective as treatments for large jaw cysts, which are common diseases in the clinic. Based on a treatment used in a previous study, this paper proposes a 'three-step method' to treat large jaw cyst and repair the bone defect by decompression, curettage, and autologous dental ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 颌骨较大囊肿是临床中常见的疾病，通过开窗减压及二次刮治可以取得良好的效果。本文在前期治疗的基础上，提出了一种“三步法”，即通过开窗减压、二次刮治及自体牙骨粉植入临床治愈颌骨较大囊肿并修复骨缺损，现就该方法的手术过程、操作要点进行介绍。. | zh-cn |
pair_32865371 | Mixed reality (MR), characterized by the ability to integrate digital data into human real feeling, is a new technique in medical imaging and surgical navigation. MR has tremendous value in surgery, but its application in oromaxillofacial head and neck oncology surgery is not yet reported. This paper reports the applic... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 混合现实技术是一种全新的医学影像及手术导航技术，其特点是可以将数字化信息整合至人的真实感受中从而打破虚拟和现实世界的界限。混合现实技术在外科领域有着巨大的应用价值，但其在口腔颌面-头颈肿瘤外科的应用尚未见报道。本文报道了应用混合现实技术进行口腔颌面-头颈肿瘤手术的经验，并结合相关文献，对混合现实技术的优缺点、应用现状及未来发展进行了讨论。. | zh-cn |
pair_32865372 | This study aims to apply a new expert system to design removable partial denture (RPD) framework. The RPD design is completed in three steps, namely, 'selecting missing teeth', 'selecting abutment condition', and 'selecting personalized clasp'. The system can help auxiliary dentists develop personalized treatment plans... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 运用专家系统辅助口腔可摘局部义齿支架的设计，通过“缺失牙位”、“基牙状况”和“个性部件替换”3个步骤逐次多级地完成可摘局部义齿支架设计，辅助医生快速制定个性化的治疗方案，优化临床路径，减轻临床工作量。通过本系统生成牙体预备方案以指导临床备牙，防止医生在繁忙的椅旁工作中遗漏牙体预备，减少由此带来的义齿返工率。同时本系统可生成规范的支架设计电子图纸，降低手工图纸带来的不便利性，以利医技沟通，减少返工率。. | zh-cn |
pair_32865834 | Maternal mortality related to placenta accreta spectrum (PAS) disorders remains substantial when diagnosed unexpectedly at delivery. The aim of this study was to evaluate the effectiveness of a routine contingent ultrasound screening program for PAS. This was a retrospective study of data obtained between 2009 and 2019... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 基于持续性低置胎盘和以前的子宫手术对胎盘植入性疾病(PAS)进行酌情筛查的有效性 目的: 在分娩时出乎意料地诊断为胎盘植入性疾病(PAS)时，与之相关的产妇死亡率仍然较高。本研究旨在为PAS评估一项常规超声酌情筛查计划的有效性。 方法: 这是对2009年至2019年之间所获数据进行的一项回顾性研究，涉及两组:一组为筛检队列，由未经选择的参加常规孕中期超声评估的孕妇组成；另一组为诊断队列，由因疑似PAS诊断而被转介至PAS诊断服务的孕妇组成。在筛检队列中，孕中期评估时有低置胎盘的妇女得到了晚期妊娠随访，而那些有持续性低置胎盘(如前置胎盘)和以前经历过子宫手术的妇女则被转介至PAS诊断服务。由PAS诊断服务进行的超声评估包括二维灰度图和... | zh-cn |
pair_32865834 | Maternal mortality related to placenta accreta spectrum (PAS) disorders remains substantial when diagnosed unexpectedly at delivery. The aim of this study was to evaluate the effectiveness of a routine contingent ultrasound screening program for PAS. This was a retrospective study of data obtained between 2009 and 2019... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Eficacia de la detección contingente para los trastornos del espectro de la placenta acreta a partir de la placenta baja persistente y en la cirugía uterina previa OBJETIVOS: La mortalidad materna relacionada con los trastornos de la gama espectral de la placenta acreta (EPA) sigue siendo considerable cuando se diagnos... | es |
pair_32865846 | To explore how the patient is constructed and socially positioned in discourses of web-based pathways information available to people with cancer in Norway. Mixed qualitative and quantitative design, using Corpus-Assisted Critical Discourse Analysis. The study, conducted in January 2020, examined the language of one ge... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目标: 探讨挪威癌症患者在基于网络的路径信息中如何进行话语构建和进行社会定位。 设计: 使用语料库辅助的批判性话语分析,采取定性和定量方法混合的设计。 方法: 该研究于2020年1月进行,研究了一本基于网络的通用癌症路径信息手册和六本基于网络的特定癌症路径信息手册的语言。该方法利用语料库分析软件对词频和一致行进行分析,识别文本的“语言指纹”或“相关性”,然后再进行定性的批评话语分析。 结果: 分析确定了三个核心话语,其构建了不同的患者:(a) 以简短、包容性话语描述的一位积极参与的人员;(b)以主导的、医学的和跨专业的专家话语中描述的缺乏对自身情况认知或感知的被动性人员;以及(c)变成路径话语中的一个疾病和代码。 结论: 该研究提供... | zh-cn |
pair_32865848 | To explore the palliative care experiences of forced migrant children, families, and healthcare professionals (HCPs) highlighting successes, challenges, and associated practice implications. Systematic literature review. The following search engines were searched from 2008 - 2018: Allied and Complementary Medicine Data... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目标: 探讨被迫移民儿童、家庭和医疗专业人员(HCP)的姑息治疗经验,强调成功、挑战和相关实践意义。 设计: 系统文献回顾。 数据来源: 搜索2008年至2018年以下搜索引擎中的内容:英国联合补充医学数据库、CINAHL护理学全文权威数据库、联机医学文献分析和检索系统(MEDLINE),荷兰医学文摘数据库(Embase)、ProQuest学位论文文摘索引数据库、Scopus电子数据库、心理学文摘(PsycINFO)和科学网。此外,还进行了广泛的参考文献和引文检查。 评审方法: 系统回顾遵循PRISMA指南,编制PROSPERO注册协议编号是CRD42019129200。入选标准为英语类的定性、定量或混合方法研究。采用混合方法评价工... | zh-cn |
pair_25342037 | MicroRNAs (miRNAs) is a group of non-coding small RNA molecules, which play important roles in the development of tumor. The mechanisms of various kinds of miRNAs in lung cancer still need to be further elucidated. This study investigated the function of miR-614 on lung cancer cell invasion and proliferation. Real-time... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 背景与目的 MicroRNAs（miRNAs）是一种非编码的小分子RNA，在肿瘤的发生发展过程中发挥着重要的作用，各种miRNAs对肺癌的作用及机制仍需进一步阐明。本研究探讨了miR-614对肺癌细胞增殖和侵袭的作用及机制。方法 应用实时定量PCR检测miR-614在高低不同转移能力肺癌PGCL3和PGLH7细胞中的表达水平；脂质体2000介导分别转染miR-614类似物和抑制物入PGCL3和PGLH7细胞，应用Transwell实验检测miR-614对肺癌细胞侵袭的作用；应用CCK8实验和BrdU掺入实验检测miR-614对肺癌细胞增殖的作用；生物信息学软件预测miR-614潜在的靶基因，双荧光素酶报告基因验证miR-614是否作... | zh-cn |
pair_25342038 | It is unclear how could endostatin effect tumor lymphangiogenesis? The aim of this study is to explore inhibitory effect of recombinant human endostatin injection (endostar) on lymphangiogenesis in non-small cell lung cancer (NSCLC) tissue and its effect on circulating tumor cells (CTC) in peripheral blood. Tumor-beari... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 背景与目的 血管内皮抑素可以抑制肿瘤新生血管的生成，但对肿瘤微淋巴管的形成与发展是否存在抑制效应引起我们关注。本研究旨在探讨重组人血管内皮抑素（recombinant human endostatin injection）对非小细胞肺癌组织中血管内皮生长因子（vascular endothelial growth factor, VEGF）-C、VEGF-D和VEGF受体（VEGFR）-3表达及对外周血循环肿瘤细胞数目的影响。方法 荷瘤裸鼠随机分为空白对照组、顺铂组、不同浓度重组人血管内皮抑素组及重组人血管内皮抑素+顺铂组，连续给药2周。1周后检测肿瘤组织中VEGF-C、VEGF-D、VEGFR-3的表达水平和微淋巴管密度。免疫荧光... | zh-cn |
pair_25342039 | It has been proven that video assited thoracoscopic surgery (VATS) achieved the same survival rates compared with traditional open chest operation in the treatment of early stage of lung cancer. but it is unclear if there is any difference of body inflammatory reaction between the two operation. The aim of this study i... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 背景与目的 胸腔镜治疗早期肺癌在预后方面取得与传统开胸手术方式相同的效果，患者在这两种术式术后恢复方面是否存在差别是最近研究的热点。本研究旨在探讨胸腔镜治疗早期周围型肺癌根治术患者机体术后炎性状态变化。方法 选取71例于天津医科大学总医院行早期周围型肺癌根治术的患者为研究对象，根据手术方式不同分为胸腔镜组35例和开胸手术组36例，比较两组患者手术时间、出血量、淋巴结清扫个数、术后胸管留置时间、胸引量及术前1 d，术后3 d和术后7 d的C-反应蛋白（C-reactive protein, CRP）、α-肿瘤坏死因子（tumor necrosis factor-α, TNF-α）、白介素-6（interleukin-6, IL-6）、... | zh-cn |
pair_25342041 | Chemotherapy is one of the primary treatment for malignant tumors. Tumor multidrug resistance (MDR) is a major cause of clinical failure of chemotherapy; however the mechanisms of chemo-resistance have not been fully elucidated. Recently, microRNA is one of the new hotspots in life science. MicroRNA regulates the expre... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 化学药物治疗（简称化疗）是目前治疗恶性肿瘤的主要手段之一，但肿瘤的多药耐药（multidurg resistance, MDR）是临床化疗失败的主要原因之一，然而肿瘤的耐药机制至今尚未被完全阐明。microRNA是近年来生命科学新的研究热点之一，microRNA通过在转录后水平调控基因表达而参与调控一系列的生命活动，包括细胞增殖、凋亡、脂肪代谢、神经元发育、激素分泌、肿瘤血管生成、干细胞分化、肿瘤细胞浸润及转移等多种生理和病理过程。最近的研究表明，microRNA对多基因表达的调控具有高效性和特异性，对靶基因的异常调控可能构成肿瘤耐药机制，是肿瘤耐药复杂性调控的重要构成部分。因此，对microRNA与肿瘤耐药性的研究具有现实意义。本... | zh-cn |
pair_25342042 | Lung cancer is the leading cause of cancer-related mortality in the worldwide. The discovery of drive gene makes tumor treatment is no longer 'one-size-fits-all'. Targeted therapy to change the present situation of cancer drugs become 'bullet' with eyes, the effect is visible and bring a revolution in the treatment of ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 肺癌是癌症死亡的重要原因。驱动基因的发现使肿瘤治疗不再“一刀切”。靶向治疗改变了癌症药物治疗的现状成为“带眼睛的子弹”，其疗效可见并为肺癌治疗带来一场革命。驱动基因及靶向治疗已经成为非小细胞肺癌（non-small cell lung cancer, NSCLC）新的代名词。2013年中国美国临床肿瘤学会（American Society of Clinical Oncology, ASCO）年会发布了关于NSCLC的11种驱动基因突变频率，本文将就此11种NSCLC驱动基因突变的结构、功能及靶向药物治疗进行阐述。 | zh-cn |
pair_25342044 | Nano-silicon dioxide widely distributed in plastic, rubber, ceramics, paint, adhesives, and many other fields, and it is the product of coal combustion. A growing evidence shows that nano-silicon dioxide has certain correlation with respiratory system disease. In this paper, we synthesized existing researches of domest... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 纳米二氧化硅广泛分布于塑料、橡胶、陶瓷、涂料、粘合剂等众多领域，也是煤、石油等物质的燃烧的产物之一。越来越多的证据显示纳米二氧化硅与呼吸系统病变存在一定的相关性。本文综合国内外研究，对纳米颗粒的肺毒性进行概述，并从纳米二氧化硅的理化性质、暴露条件及其在肺部疾病的致病机制等方面进行综述。 | zh-cn |
pair_25342045 | Primary pulmonary lymphoma (PPL) is an extranodally original disorder, which is involving the lung parenchyma and (or) bronchial with clonal lymph cell abnormal proliferation. PPL is very rare in clinics, accounting for only 0.5%-1% of primary lung tumors, and can easily be misdiagnosed or missed due to the nonspecific... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 原发性肺淋巴瘤（primary pulmonary lymphoma, PPL）是一种起源于淋巴结外，累及肺实质和（或）支气管的克隆性淋巴细胞增殖性疾病。PPL临床非常罕见，仅占肺部原发性恶性肿瘤的0.5%-1%，常因其临床特征及影像学特征无特异性而容易被误诊或漏诊。该病的治疗存在争议，手术及术后的辅助化疗为目前多数患者的治疗方案。本文将报道1例罕见的原发性肺淋巴瘤，并初步讨论其诊断和治疗。 | zh-cn |
pair_26932207 | To study the safety and efficiency of the transfection of antisense oligonucletide into kidney mediated by lipid microbubbles, and to evaluate its potential clinical application. The potential and conditions regarding the transfection self-made lipid microbubbles (CY5)-labeled-oligonucleotide (ODN) or CY5-labeled-ODN c... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的：探讨超声联合自制脂质体微泡(lipid contrast agent，LCA)转染肾脏的条件和效率。方法：HE染色、肝肾功能检测评价其安全性；荧光显微镜评价其转染效率；RT-PCR和Western印迹检测其对结缔组织生长因子(connective tissue growth factor，CTGF)表达的影响。结果：超声联合LCA显著增强基因在肾脏内的转导效率，CY5标记的寡核苷酸主要表达在85%~90%的肾小球、肾小管和间质区；血液生化指标无明显改变；转染后第7天的LDH水平均低于0天(P<0.05)；转染至肾脏的CTGF反义寡核苷酸成功抑制了CTGF的表达。结论：超声联合LCA的基因转移系统显著增强基因转移和表达的效率，该... | zh-cn |
pair_26932210 | To explore the effect of compound malt pills (CMP) on polycystic ovarian syndrome (PCOS) rat model induced by letrozole and the underlying mechanisms.
To establish a PCOS rat model, 48 female SD rats aged 6 weeks were randomly divided into 6 groups (n=8): A normal group, a model control group, a positive control group... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的：观察复方麦芽丸对来曲唑诱导的多囊卵巢综合征(polycystic ovarian syndrome，PCOS)大鼠模型雌激素受体α亚型(estrogen receptor α，ERα)和雌激素受体β亚型(estrogen receptor β，ERβ)的影响，探讨其对PCOS的作用机制。方法：建立PCOS大鼠模型，48只6周龄雌性SD大鼠随机均分为6组(正常组、模型对照组、阳性对照组、复方低剂量组、复方中剂量组、复方高剂量组)，21 d造模成功后，灌胃治疗21 d。观察治疗后各组大鼠卵巢组织形态变化，采用免疫组织化学、Western 印迹和RT-PCR检测各组大鼠卵巢组织中ERα和ERβ蛋白的表达。结果：模型对照组大鼠卵巢囊状... | zh-cn |
pair_26932212 | To explore the prognosis and surgical method for diffuse-type advanced gastric cancer (AGC).
The clinicopathological data of patient, who underwent curative gastrectomy in the Second Hospital Affiliated to Lanzhou University from 2005 to 2010, were analyzed retrospectively. The prognostic factors of diffuse-type AGC w... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的：探讨弥漫型进展期胃癌(advanced gastric cancer，AGC)的预后及手术方式的选择。方法：回顾性分析2005年至2010年兰州大学第二医院行根治性胃癌切除术的287例AGC患者的临床病理资料，采用Cox回归模型分析弥漫型AGC预后的影响因素。根据手术方式的不同将其分为全胃切除组(n=120)和部分胃切除组(n=167)，采用Kaplan-Meier法计算其生存率，生存率的比较采用Log-rank法检验。结果：单因素分析显示体质量指数、淋巴结切除数、Borrmann分型、肿瘤大小、T分期、N分期、TNM分期、切除范围、手术切缘、神经及脉管浸润、术后并发症均与弥漫型AGC预后相关(均P<0.01)；多因素分析显示... | zh-cn |
pair_26932213 | To evaluate the efficacy and safety of peroral endoscopic myotomy (POEM) for achalasia cardia (AC).
A total of 62 patients with AC were enrolled and treated with POEM in the Third Xiangya Hospital, Central South University from April 2012 to October 2014. The symptoms and complications were retrospectively analyzed.
... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的：探讨经口内镜下肌切开术(peroral endoscopic myotomy，POEM)在贲门失弛缓症(achalasia cardia，AC)治疗中的疗效及安全性。方法：分析2012年4月至2014年10月期间62例确诊为AC行POEM治疗的患者的疗效、并发症及复发情况。结果：62例患者中男32例，女30例，年龄14~68 (43.2±5.6)岁，Eckardt评分II级(4~6分)25例，III级(≥7分)37例(其中Eckardt评分12分者20例)，有13例曾行贲门球囊扩张2~3次。1例因黏膜下层严重粘连改行经胸贲门肌层切开术。POEM操作时间为(60.8±15.1) min，术后有14例出现轻微皮下气肿，5例气腹经腹... | zh-cn |
pair_26932214 | To explore the compliance of extramural hospital treatment and the long-term survival status in patients with acute myocardial infarction (AMI) in Chongqing.
A total of 636 patients with AMI, from grade 3 and first-class hospitals in Chongqing during Jan 2005 and Jan 2009, were enrolled for this study. The patients we... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的：探讨重庆地区急性心肌梗死患者院外治疗依从性及其对远期生存状况的影响。方法：本研究收集了重庆部分三甲医院2005年1月至2009年1月确诊为急性心肌梗死且治疗后出院的患者636例。通过不同方式对其进行5年的随访，了解患者在院外的治疗情况及影响因素。结果：最终574例入选，心因性死亡180例，病死率为31.4%，院外用药依从性差为死亡患者的主要特征。结论：治疗依从性差为本地急性心肌梗死患者5年预后的独立影响因素。. | zh-cn |
pair_26932215 | To evaluate the change in accommodative lag and accommodation convergence/accommodation (AC/A) after patients with myopia wear orthokeratology lenses.
A total of 48 myopic subjects (a test group), who wore orthokeratology lenses regularly, and 48 myopic subjects (a control group), who wore spectacles regularly, were ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的：研究近视患者配戴角膜塑形镜后调节滞后量及调节性集合与调节的比值(accommodative convergence/accomodation，AC/A)的改变。方法：收集2011年10月至2013年10月在长沙市第四医院视光中心规范验配、随诊的低、中度青少年近视患者96例，其中配戴角膜塑形镜者(试验组)和配戴框架眼镜者各48例(对照组)，使用融像性交叉柱镜法(FCC 法)测量其注视眼前40 cm处视标时的调节滞后量，采用Von Grafe 法检查视近处斜视度，梯度法测AC/A值。对两组的调节滞后量和AC/A值进行统计学分析。结果：与对照组比较，低、中度近视患者试验组在随访的1，3，6，12个月时AC/A值均减小，调节滞后量均减... | zh-cn |
pair_26932216 | To compare the results of the three methods of Suresight handheld autorefractor, table-mounted autorefractor and retinoscopy in examination of juveniles patients with or without cycloplegia.
Firstly, 156 eyes of 78 juveniles (5 to 17 years old) were examined by using WelchAllyn Suresight handheld autorefractor and NID... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的：使用视力筛查仪、电脑验光仪与视网膜检影等3种常用验光方法比较分析青少年屈光不正患者散瞳前后的检测结果。方法：对78例(156只眼)53~17岁青少年分别在自然瞳孔下应用WelchAllyn Suresight手持式视力筛查仪及NIDEK ARK-510A型自动电脑验光仪进行验光。充分睫状肌麻痹散瞳后，行视力筛查仪、电脑验光仪和视网膜检影3种验光法。结果：各方法散瞳前球镜代数值均低于散瞳后，数值更偏近视(P<0.05)；散瞳前视力筛查仪与散瞳后的检影验光比较，球镜值、柱镜值和散光轴位差异均无统计学意义(P>0.05)，两者的一致性优于电脑验光与视网膜检影，但是所得数值偏近视倾向；散瞳前电脑验光与检影验光比较，球镜值和柱镜值差异均... | zh-cn |
pair_26932217 | To evaluate the prescription behavior for outpatients in primary health care institutions of Yiyang and to provide scientific basis for promoting the rational use of drugs.
A multi-stage random sampling method was conducted in 21 primary health care institutions from Yiyang. Fifteen prescriptions were randomly selecte... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的：分析益阳市基层医疗机构门诊处方行为及影响因素，并对其行为进行综合评价，为提高合理用药水平提供科学依据。方法：采用多阶段随机抽样的方法，随机抽取益阳市21家基层医疗机构，每家机构每月随机抽取15张处方，一年共3 780张，逐一登记处方信息，分析评价处方行为。结果：每张处方平均用药种数和注射剂处方百分率超过国际标准。未成年患者多重用药、抗生素、激素和注射剂处方使用率较高，女性患者基本药物使用率较高，夏、秋季抗生素、激素使用率较高，乡镇卫生院多重用药、抗生素、注射剂和基本药物使用率较高，皮肤和皮下组织疾病多重用药处方使用率较高，呼吸系统疾病抗生素、激素和静脉注射处方使用率较高。大部分基层医疗机构合理用药水平为中上等。结论：益阳市基层... | zh-cn |
pair_26932218 | To understand the associated factors on human immunodeficiency virus (HIV) transmission via heterosexual contact and to provide evidence for decision-maker for prevention of HIV.
Questionnaire survey was conducted in 250 HIV-positive persons to understand their socio-demographic characteristics and sexual behavior. Me... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的：了解经异性性接触途径感染人类免疫缺陷病毒(HIV)/获得性免疫缺乏综合征(AIDS)的患者作为艾滋病传染源传播HIV情况，为艾滋病防治决策提供依据。方法：对250名HIV阳性人员进行问卷调查，了解其社会人口学特征、异性性行为等有关情况，同时溯源调查与其性行为密切接触的易感人群，检测、了解其艾滋病感染情况，计算续发率和增长率。采用病例对照分析方法探讨传染源继续传播HIV的相关因素。结果：250名传染源的431名易感接触者有59人HIV阳性，续发率为13.7%(59/431)，增长率为23.6%(59/250)。传染源继续传播HIV的相关因素为：艾滋病防治知识知晓情况、知晓感染后心理反映、与配偶/固定性伴安全套使用情况、与非固定性... | zh-cn |
pair_26932219 | Next generation sequencing (NGS) has developed very rapidly in the last decade. Compared with Sanger sequencing, NGS has the advantages of high sensitivity and high throughput. Movement disorders are a common type of neurological disease. Although traditional linkage analysis has become a standard method to identify th... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 在过去10年中，下一代测序技术(next generation sequencing，NGS)得到了十分迅速的发展。与传统测序相比，NGS具有高通量和高灵敏性等优点。孟德尔型运动障碍是一类常见的神经疾病。由于样本较少等原因，通过连锁分析等传统方法寻找新的孟德尔型运动障碍尤其是罕见疾病的致病基因已经变得越来越困难，而NGS则可作为发现新的致病基因的理想手段。目前NGS已被应用于多种孟德尔型运动障碍的研究。本文将从基因组和转录组的角度对NGS在孟德尔型运动障碍中的最新应用进行综述，并展望NGS在罕见孟德尔型疾病中的应用。. | zh-cn |
pair_26932220 | Embryonic stem cells (ESCs) is one of the best cell types for regenerative medicine. It is derived from inner cell mass of the blastocyst stage and characterized by self-renewal and pluripotency, which are regulated by kinds of signal molecules, such as the Wnt/β-catenin signaling pathway. β-catenin is a multifunctiona... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 胚胎干细胞来源于胚胎发育过程中的囊胚内细胞团，是再生医学研究中的“种子细胞”，具有自我更新能力和多能性。这种特性受到多种信号通路的调控，其中Wnt/β-catenin信号通路在此调控过程中发挥着十分重要的作用。β-catenin是一种多功能蛋白，是Wnt/β-catenin信号通路中的开关分子，其参与的调控网络在时间和空间上调控胚胎干细胞自我更新和向三胚层分化的能力。因此，明确β-catenin对胚胎干细胞自我更新与多能性的调控机制，能够为胚胎干细胞的研究和应用提供有益的借鉴。. | zh-cn |
pair_26932221 | Obstructive sleep apnea syndrome (OSAS) is a complicated chronic disease caused by certain reasons, characterized by obstruction of the upper airway and apnea or hypopnea during sleep, which can be followed by anoxia, snoring and daytime sleepiness. Recent studies have shown that hypertension is closely connected to OS... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 阻塞性睡眠呼吸暂停综合征(obstructive sleep apnea syndrome，OSAS)是一种常见但易被忽视的疾病，是由于某些原因引起上呼吸道阻塞而出现睡眠呼吸暂停并伴有缺氧、鼾声、白天嗜睡等症状的慢性睡眠呼吸障碍性疾病。OSAS与高血压密切相关，可能通过多种机制引起高血压的发生。OSAS的诊断主要依据患者的病史、体征及多导睡眠图监测结果，如睡眠呼吸暂停和低通气次数。主要可通过持续气道内正压通气、口腔矫正、药物及改变生活方式等进行改善与治疗。. | zh-cn |
pair_26932222 | Long-term therapy should be administrated for patients with schizophrenia and the medication adherence is very important for the prognosis and outcome in these patients. In this study, we screened the literatures from various databases in accordance with our search criteria. A total of 11 literatures with the results o... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 大多数精神分裂症患者需要长期维持治疗，服药依从性是影响精神分裂症患者预后及转归非常重要的因素。笔者采用关键词检索中英文数据库，对检索到的文献进行初筛，然后回顾已检索文献的参考文献，综合专家建议，纳入样本人群为精神分裂症患者并且报告了信度和效度的参考文献，共11篇。将这11篇文献中服药依从性的测量方法进行归类，可分为主观和客观两类，主观方法包括药物态度问卷、服药影响因素评定量表、服药影响因素和信念的简易评价、简明依从性评定量表、药物依从性评定量表和Morisky量表；客观方法包括血(尿)药浓度的检测、药片计数、药房记录和电子药瓶计数。精神分裂症患者服药依从性的测量方法都有其局限性，研究者在进行服药依从性的测量时，推荐选择两种或者两种以... | zh-cn |
pair_26937311 | Chronic pain remains a daunting clinical challenge, affecting 30% of people in the United States and 20% of the global population. People meeting this challenge by achieving wellbeing while living with pain are a virtually untapped source of wisdom about this persistent problem. Employing a concurrent mixed-methods des... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 慢性疼痛仍然是一项艰巨的临床挑战，它影响美国人口的 30% 和全球人口的 20%。在经受疼痛的同时还能活得幸福的人们实际上是应对这种持续性问题的、尚未开发的智慧源泉。我们应用并行的混合方法设计，通过半结构化的访谈和标准化的问卷，研究了 80 名经受慢性疼痛但有“积极的故事要讲述”的人们。深度访谈的重点内容是哪些方法有用、面临哪些困难、发生了什么变化以及对情况类似的其他人有什么建议。主要定义主题包括无怨接受、开放、自我效能感、希望、毅力、自律、肌肉运动知觉、整体方法和综合疗法、自我保健、精神、社会支持和治疗性生活习惯，如音乐、写作、美术、园艺和感受大自然。成长与智慧的主题包括改善关系、观点、明晰、力量、感激、同情、新方向和精神变化。根... | zh-cn |
pair_26937311 | Chronic pain remains a daunting clinical challenge, affecting 30% of people in the United States and 20% of the global population. People meeting this challenge by achieving wellbeing while living with pain are a virtually untapped source of wisdom about this persistent problem. Employing a concurrent mixed-methods des... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | El dolor crónico sigue siendo un desafío clínico abrumador, que afecta al 30 % de las personas de los Estados Unidos y al 20 % de la población mundial. Las personas que se enfrentan a este reto logrando bienestar mientras conviven con el dolor son una fuente prácticamente sin explotar de sabiduría sobre este persistent... | es |
pair_26937312 | Mindfulness- and acceptance-based interventions are increasingly studied as a potential treatment for a variety of mental conditions. To assess the effects of mindfulness- and acceptance-based interventions on psychotic symptoms and hospitalization in patients with psychosis. MEDLINE/PubMed, Embase, the Cochrane Librar... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 背景：作为各种精神疾病的潜在治疗，基于正念和无怨接受的干预正得到越来越多的研究。目的：评估基于正念和无怨接受的干预对精神病患者的精神病症状和住院治疗的影响方法：从开始到 2015 年 4 月筛选了MEDLINE/PubMed、Embase, Cochrane Library 和 PsycINFO。评估精神病患者的精神病症状或住院治疗时，分析了随机对照试验 (Randomized Controlled Trial, RCT)；情绪反应、无怨接受、正念以及安全被定义为次要结果。结果：包括 8 项 RCT，共计 434名患者，对基于正念（4 项 RCT）或基于无怨接受（4 项 RCT）的干预与常规治疗或注意力控制进行了比较。6 项 RCT... | zh-cn |
pair_26937312 | Mindfulness- and acceptance-based interventions are increasingly studied as a potential treatment for a variety of mental conditions. To assess the effects of mindfulness- and acceptance-based interventions on psychotic symptoms and hospitalization in patients with psychosis. MEDLINE/PubMed, Embase, the Cochrane Librar... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Las intervenciones basadas en la conciencia plena y la aceptación se estudian cada vez más como posible tratamiento para varios trastornos mentales. Evaluar los efectos de las intervenciones basadas en la conciencia plena y la aceptación en los síntomas psicóticos y en la hospitalización de los pacientes con psicosis. ... | es |
pair_26937313 | Integrative medicine (IM) approaches are sometimes used to manage sickle cell disease (SCD)-related pain. The purpose of this research is to (1) understand provider perspective towards the use of IM for pain in children with SCD at a large urban children's hospital and (2) provide recommendations on how to better promo... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 目的：综合医学 (Integrative Medicine, IM) 方法有时用于管理 镰状细胞病 (Sickle Cell Disease, SCD) 相关疼痛。本研究的目的在 于：(1) 了解提供者关于在大城市 儿童医院应用 IM 管理儿童 SCD 患 者疼痛的看法；(2) 提出关于如何 更好地为儿童和青少年 SCD 患者推 广使用 IM 的建议。方法：经过机构审查委员会批准 后，结合标准型立意抽样，使用 定性个案研究方法从血液专科选 择提供者，以便为研究充分提供 信息。用录音磁带完成半结构化 的访谈，以便转录。用 NVivo10 分析软件（澳大利亚维多利亚州 唐卡斯特市 QSR International Pty Ltd）将数... | zh-cn |
pair_26937313 | Integrative medicine (IM) approaches are sometimes used to manage sickle cell disease (SCD)-related pain. The purpose of this research is to (1) understand provider perspective towards the use of IM for pain in children with SCD at a large urban children's hospital and (2) provide recommendations on how to better promo... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Los enfoques de la medicina integral se usan a menudo para tratar el dolor relacionado con la drepanocitosis. El propósito de esta investigación es (1) entender el punto de vista del personal sanitario en cuanto al uso de la medicina integral para el dolor en los niños con drepanocitosis en un gran hospital infantil y ... | es |
pair_26937315 | Beneficial correlations are suggested between food preparation and home food preparation of healthy choices. Therefore, there is an emergence of culinary medicine (CM) programs directed at both patients and medical professionals which deliver education emphasizing skills such as shopping, food storage, and meal prepara... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 背景：食品制备与健康消费之间存在有益的相关性。因此，有越来越多的烹饪医学 (Culinary Medicine, CM) 项目向患者提供医学教育课程，重点介绍购物、食品存储和膳食准备等方面的技能。目的：本文章的目的在于介绍新兴的 CM 项目，并设想本领域如何才能走向成熟。方法：2015 年 4 月，通过 CM 和生活方式医学领导者调查确定了 10 个 CM项目。项目主管进行了叙述，介绍了各自项目的结构、课程、教育设计、提供方式、资金来源和成本。进行了访谈，以优化数据采集。结果：所有 10 个项目提供的医疗教育课程每年共计培训 2654 名卫生保健专业人员。教育目标不尽相同，大致领域为（1）提供者的自我行为；（2）营养知识；（3）营养... | zh-cn |
pair_26937315 | Beneficial correlations are suggested between food preparation and home food preparation of healthy choices. Therefore, there is an emergence of culinary medicine (CM) programs directed at both patients and medical professionals which deliver education emphasizing skills such as shopping, food storage, and meal prepara... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Se sugieren correlaciones beneficiosas entre la preparación de la comida y el consumo de opciones saludables. Por consiguiente, están creciendo los programas de medicina culinaria que proporcionan conocimientos sobre los pacientes y la educación médica enfatizando habilidades como la compra, la conservación de los alim... | es |
pair_26937316 | Many people suffering from low back pain (LBP) have found conventional medical treatments to be ineffective for managing their LBP and are increasingly turning to complementary and alternative medicine (CAM) to find pain relief. A comprehensive picture of CAM use in the LBP population, including all of the most commonl... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 背景：许多有腰背痛 (Low Back Pain, LBP) 的人都发现常规药物治疗不足以管理其腰背痛，并越来越多地转向补充和替代医学 (Complementary and Alternative Medicine, CAM) 来疼痛缓解。需要全面描绘 CAM 在 LBP 人群中的使用情况，包括所有最常用的方式。研究目标：通过限制性与非限制性 LBP 考察在美国 LBP 人群中使用 CAM 的普遍性和感知利益，同时评估去年在 LBP 人群中使用 CAM 的几率。方法：数据来自于 2012 年国家健康访谈调查，替代健康补充。我们考察了美国成人 LBP 患者的全国代表性样本（N=9665，未加权）。使用多次逻辑回归估计去年使用 CAM的... | zh-cn |
pair_26937316 | Many people suffering from low back pain (LBP) have found conventional medical treatments to be ineffective for managing their LBP and are increasingly turning to complementary and alternative medicine (CAM) to find pain relief. A comprehensive picture of CAM use in the LBP population, including all of the most commonl... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Muchas personas que sufren lumbalgia han descubierto que los tratamientos médicos convencionales no son eficaces para tratarla y están cambiando a la medicina complementaria y alternativa para encontrar el alivio a su dolor. Es necesario tener una imagen completa del uso de la medicina complementaria y alternativa en l... | es |
pair_26937317 | Traditional Chinese medicine, as it is understood and adopted by those with a growing interest in complementary and alternative practices to biomedicine, is often used as an umbrella term for traditional medical practices from regions within and bordering the People's Republic of China. However, there are multiple dist... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 背景：传统中药为越来越多的人们所理解，并将其作为生物医学的补充和替代医疗，它通常涵盖中华人民共和国境内各地区的传统医疗实践。然而，中国有许多独特的医学传统，其中包括维吾尔族、藏族和蒙古族。目的：了解中国境内三种不同文化践行的独特医疗体系之共性与差异非常重要。方法：我们通过深度分析形成各个体系之基础的各种信念与理论，追踪了融入维吾尔族、藏族和蒙古族医疗体系的概念之根源。此外，我们比较了这三种体系之间的诊断技术和对照治疗模式。讨论：我们讨论了体液学说、体质学说、元素学说、器官学说和阴阳学说。我们发现，失衡是疾病的常见病因，但在维吾尔族、藏族和蒙古族体系中，解释此类失衡的条件和外部因素不尽相同。通过这些比较，我们力求突出这些文化使用的独特... | zh-cn |
pair_26937317 | Traditional Chinese medicine, as it is understood and adopted by those with a growing interest in complementary and alternative practices to biomedicine, is often used as an umbrella term for traditional medical practices from regions within and bordering the People's Republic of China. However, there are multiple dist... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | La medicina tradicional china, tal y como está entendida y adoptada por un interés creciente en prácticas complementarias y alternativas a la biomedicina, se usa a menudo como un término paraguas para las prácticas médicas tradicionales procedentes de las regiones internas y limítrofes a la República Popular China. Sin... | es |
pair_26937318 | Excessive gestational weight gain (EGWG) places women at increased risk for complications during pregnancy and also increases the likelihood that they will remain overweight after pregnancy. The Institute of Medicine (IOM) has recommended weight gain guidelines based on pre-pregnancy body mass index (BMI), but evidence... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 背景： 孕期体重过度增加（Excessive Gestational Weight Gain，EGWG）使得女性在怀孕期间的并发症风险升高，还增大了其在怀孕后超重的可能性。医学研究所 (Institute of Medicine, IOM) 已根据怀孕前的体重指数（Body Mass Index，BMI）提出体重增加指南，但以证据为基础以实现这些目标的策略有限。目的：本次回顾讨论了 EGWG 相关的因素，目的在于确定未来干预的目标。方法：利用 PubMed 数据库进行搜索，找到 1995 年至 2014 间发表的、与孕期体重过度增加有关的所有英语论文。论文按主题进行 分组：孕前 BMI、社会人口特征、饮食与锻炼、心理特征和产前保健的... | zh-cn |
pair_26937318 | Excessive gestational weight gain (EGWG) places women at increased risk for complications during pregnancy and also increases the likelihood that they will remain overweight after pregnancy. The Institute of Medicine (IOM) has recommended weight gain guidelines based on pre-pregnancy body mass index (BMI), but evidence... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | El aumento de peso excesivo durante el periodo gestacional hace que las mujeres tengan un mayor riesgo de complicaciones durante el embarazo y también aumenta la probabilidad de que mantengan el sobrepeso tras el embarazo. El Instituto de Medicina ha recomendado unas pautas de aumento de peso basadas en el índice de ma... | es |
pair_26937320 | Postdural puncture headache (PDPH) is a recognized complication of neuraxial anesthesia. This case report documents 1 patient who developed PDPH following epidural anesthesia for postoperative pain control. The patient declined conventional treatments, including an epidural blood patch and intravenous caffeine. This re... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 后硬脑膜穿刺头痛（ PDPH ）是椎管内麻醉的一个公认的并发症。这起案件的报告文件一个病人谁开发PDPH以下硬膜外麻醉术后疼痛控制。患者拒绝常规治疗方法，包括硬膜外血液补丁和静脉注射咖啡因。该报告记录成功利用辅助针灸治疗PDPH的管理。有必要对针灸作为一种潜在的辅助治疗PDPH进行更多的研究，特别是对病人谁也不愿意接受更多侵入性治疗。. | zh-cn |
pair_26937320 | Postdural puncture headache (PDPH) is a recognized complication of neuraxial anesthesia. This case report documents 1 patient who developed PDPH following epidural anesthesia for postoperative pain control. The patient declined conventional treatments, including an epidural blood patch and intravenous caffeine. This re... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Dolor de cabeza posterior a la punción dural (CPPD) es una complicación reconocida de la anestesia neuroaxial. Este informe documenta casos de un paciente que desarrolló CPPD después de la anestesia epidural para el control del dolor postoperatorio. El paciente se negó tratamientos convencionales, incluyendo un parche ... | es |
pair_26937321 | The association between gastroesophageal reflux disease (GERD) and asthma, although well established in adults, is less strong in the pediatric age group. Benefits of proton pump therapy are limited across age ranges. While there is a growing body of literature on the use of complementary treatments for both asthma and... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 胃食管反流病（Gastroesophageal Reflux Disease，GERD）与哮喘之间的关系虽然在成人中非常明确，但在儿科年龄组中则不甚明确。质子泵疗法的好处在各年龄段有限。尽管有关对哮喘和 GERD 两者使用补充治疗的文献越来越多，但重点关注对 GERD-哮喘关系的治疗好处的研究很少。我们介绍了一位罹患哮喘和 GERD 的 2 岁男孩的病例，他对吸入式低剂量糖皮质激素、β 模拟疗法和 6 周质子泵抑制剂疗程无反应。我们注意到，对他使用健胃散联合颠茄草粉口服制剂（一种含有洋甘菊、颠茄草、铋和亚锑酸盐的人智学药物）时，症状逐渐消失。洋甘菊和铋已知具有胃部保护特性，颠茄草含有具有支气管舒张作用的抗胆碱能药物。这些补充药物似乎... | zh-cn |
pair_26937321 | The association between gastroesophageal reflux disease (GERD) and asthma, although well established in adults, is less strong in the pediatric age group. Benefits of proton pump therapy are limited across age ranges. While there is a growing body of literature on the use of complementary treatments for both asthma and... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | La asociación entre la enfermedad por reflujo gastroesofágico (ERGE) y el asma, aunque está bien establecida en adultos, es menos fuerte en el grupo de niños. Los beneficios del tratamiento de bomba de protones está limitado entre rangos de edad. A pesar de que existe un aumento en el volumen de bibliografía acerca del... | es |
pair_26937322 | Cancer-related gastrectomy can cause post-gastrectomy syndrome, which includes weight loss, dumping syndrome, and reflux esophagitis and negatively affects the quality of life. Comprehensive and individualized patient management is required; however, there is a limit to Western medicine's ability to treat these symptom... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 癌症相关胃切除术可能导致胃切除后综合征，其中包括体重下降、倾倒综合征、反流性食管炎和对生活质量的负面影响。需要全面和个性化的病患管理；但西药治疗这些症状的效果有限。日本传统汉方医学采用适应每一个人的症状和体质的疗法。我们用汉方药物旋复花代赭石汤 (senpukukataishasekito)治疗过一名 68 岁的胃切除后综合征男性患者。他在 66 岁时被诊断患有 II-A 期胃癌，并接过了保留幽门腹腔镜胃切除术，然后接受化疗 13 个月。他因为化疗相关的疲劳、术后体重下降和肢体麻木前来我们诊所就诊。给他开了八味地黄丸 (hachimijiogan) 和补中益气汤 (hochuekkito)。第二次就诊时，他主诉胃部不适，因此我们给他... | zh-cn |
pair_26937322 | Cancer-related gastrectomy can cause post-gastrectomy syndrome, which includes weight loss, dumping syndrome, and reflux esophagitis and negatively affects the quality of life. Comprehensive and individualized patient management is required; however, there is a limit to Western medicine's ability to treat these symptom... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | La gastrectomía relacionada con el cáncer puede provocar el síndrome de evacuación gástrica rápida, que incluye pérdida de peso, evacuación gástrica rápida y esofagitis por reflujo gastroesofágico, y afecta negativamente a la calidad de vida. Es necesario el tratamiento completo e individualizado del paciente; sin emba... | es |
pair_26937323 | Pediatric obsessive-compulsive disorder (OCD) is prevalent in 1% to 2% of the population. Emerging studies have correlated non-celiac gluten sensitivity with psychiatric conditions such as schizophrenia, depression, mania, and anxiety. This case study is the first reported case of OCD associated with non-celiac gluten ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 儿科强迫症 (Obsessivecompulsive Disorder, OCD) 在该人群中的发生率为 1% 到 2%。新兴研究将非腹腔麸质敏感性与精神分裂症、抑郁、躁狂症和焦虑等精神疾病联系在一起。本病例研究是首次报告的 OCD 与非腹腔麸质敏感性相关联的病例。本病例报告的目的在于：(1) 确定麸质敏感性是有些患者中可能的 OCD 促成因素；(2) 指出在标准治疗方案效果欠佳的患者中，综合医学方法对 OCD 管理的可能好处。一名 7 岁男孩在美国接受了多医师综合医学实践治疗，在接受包括避免麸质及其他综合医学方式在内的治疗后，OCD 症状和焦虑明显减轻，社会行为和学业成绩显著改善。患者反应迅速且没有副作用，医学研究界因此需要进一步... | zh-cn |
pair_26937323 | Pediatric obsessive-compulsive disorder (OCD) is prevalent in 1% to 2% of the population. Emerging studies have correlated non-celiac gluten sensitivity with psychiatric conditions such as schizophrenia, depression, mania, and anxiety. This case study is the first reported case of OCD associated with non-celiac gluten ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | El trastorno obsesivo compulsivo (TOC) en niños es prevalente en entre un 1 % y un 2 % de la población. Los estudios emergentes han relacionado la sensibilidad al gluten no celíaca con trastornos psiquiátricos como la esquizofrenia, la depresión, la manía y la ansiedad. Este estudio de un caso es el primer caso comunic... | es |
pair_26937324 | Stress is widely believed to play a role in the development and pathogenesis of inflammatory bowel disease (IBD), and several studies of mind-body programs have suggested benefits in this patient population. Here we describe a case report of a young man with a flare in Crohn's disease-related symptoms that improved in ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 广泛认为，压力对炎症性肠病 (Inflammatory Bowel Disease, IBD) 的进展和发病机理有影响，并且多项身心方案研究已表明在本患者人群中的好处。我们在此介绍克罗恩病症状突然发作的一名年轻男性的病例报告，他对综合多模态身心方案和新型 IBD 治疗中心的出现反应良好，症状改善。上述治疗中心融合身心方法、营养及其他方式，为罹患 IBD 的人们提供更加全面、以患者为本的护理。. | zh-cn |
pair_26937324 | Stress is widely believed to play a role in the development and pathogenesis of inflammatory bowel disease (IBD), and several studies of mind-body programs have suggested benefits in this patient population. Here we describe a case report of a young man with a flare in Crohn's disease-related symptoms that improved in ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Se cree ampliamente que el estrés juega un papel en el desarrollo y patogenia de la enfermedad intestinal inflamatoria (EII) y varios estudios de programas mente-cuerpo han sugerido beneficios en esta población de pacientes. Aquí describimos un informe de un caso de un hombre joven con reagudización de los síntomas rel... | es |
pair_26957676 | To assess progress in the provision of drinking water and sanitation in relation to national socioeconomic indicators. We used household survey data for 73 countries - collected between 2000 and 2012 - to calculate linear rates of change in population access to improved drinking water (n = 67) and/or sanitation (n = 61... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 旨在评估饮用水和卫生设施供应的进展与国家社会经济指标的相关性。. 我们使用了 73 个国家在 2000 年至 2012 年之间收集的家庭调查数据，以计算人们获得改善的饮用水 (<i>n </i>= 67) 和/或卫生设施 (<i>n</i> = 61) 的线性变化率。 为了对不同初始水平国家之间的进展进行比较，将变化的计算率规范化为 -1 至 1。在回归分析中，我们研究了人们获得的规范化的变化率和国家社会经济指标的相关性： 人均国民收入、政府效率、官方发展援助、淡水资源、教育、扶贫、基尼系数、儿童死亡率和人类发展指数。. 规范化的变化率说明大多数参与调查的国家不断取得进步，正逐步实现普及改善饮用水和卫生设施。 然而，只有大约三分之一... | zh-cn |
pair_26957676 | To assess progress in the provision of drinking water and sanitation in relation to national socioeconomic indicators. We used household survey data for 73 countries - collected between 2000 and 2012 - to calculate linear rates of change in population access to improved drinking water (n = 67) and/or sanitation (n = 61... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Évaluer les progrès réalisés dans la fourniture d'eau potable et de services d'assainissement par rapport aux indicateurs socioéconomiques nationaux. Nous avons utilisé les données d'enquêtes réalisées auprès des ménages dans 73 pays entre 2000 et 2012 pour calculer les taux de changement linéaires de l'accès de la pop... | fr |
pair_26957676 | To assess progress in the provision of drinking water and sanitation in relation to national socioeconomic indicators. We used household survey data for 73 countries - collected between 2000 and 2012 - to calculate linear rates of change in population access to improved drinking water (n = 67) and/or sanitation (n = 61... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Evaluar el progreso del suministro de agua potable y saneamiento en relación con indicadores socioeconómicos nacionales. Se utilizaron los datos de una encuesta domiciliaria realizada en 73 países (recogidos entre los años 2000 y 2012) para calcular la tasa de variación lineal del acceso mejorado de la población al agu... | es |
pair_26957676 | To assess progress in the provision of drinking water and sanitation in relation to national socioeconomic indicators. We used household survey data for 73 countries - collected between 2000 and 2012 - to calculate linear rates of change in population access to improved drinking water (n = 67) and/or sanitation (n = 61... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Оценить прогресс в снабжении питьевой водой и в вопросах санитарии в связи с национальными социально-экономическими показателями. Были использованы данные опроса семей в 73 странах, полученные в период между 2000 и 2012 годами, и по этим данным были рассчитаны линейные показатели изменения доступа населения к питьевой ... | ru |
pair_34517449 | Liver disease-associated infection is a common condition in clinic. The existence of underlying liver disease increases the morbidity, mortality, and other adverse consequences of various infections, which in turn aggravates the liver disease-associated infections progression. Therefore, liver disease and infection sho... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 肝病相关感染是临床常见情况，基础肝病的存在使多种感染的发生率和病死等不良结局增加，感染反过来也会加重肝病的进展。临床管理中既要关注肝病，也要重视感染。肝病的评估方面包括其病原学、严重程度和并发症，感染的评估方面重点关注病原学和病变部位。治疗时，肝病方面应尽可能清除病原并及时治疗并发症，感染方面应及时进行经验性病原治疗，避免应用肝损伤风险高的抗感染药物，一旦明确病原尽快转为目标治疗。. | zh-cn |
pair_34517450 | China has the highest disease burden of viral hepatitis. After understanding the epidemic characteristics of viral hepatitis in China and putting forward scientific prevention and control strategies, the Chinese government has been effectively practicing the policy of 'prevention first with combination of prevention an... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 我国是病毒性肝炎疾病负担最重的国家。在摸清我国病毒性肝炎流行特征，提出科学防控策略后，我国政府有力践行了'预防为主、防治结合'的政策。尤其是近40多年来的努力，我国在推行预防接种、加强血液筛查、规范诊疗服务、加强监管方面都采取了有力措施，并取得显著成效。甲型肝炎发病率从1990年的52.6/10万降至2019年的1.38/10万，5岁以下儿童乙型肝炎病毒表面抗原携带率从1992年的9.67%下降到2014年的0.32%，慢性丙型肝炎感染者治愈率已经实现95%以上，戊型肝炎的发病率也呈下降趋势。但是，估计2019年乙型肝炎患者的诊断率为25%，治疗率为17%；估计丙型肝炎诊断率为30%，治疗率为9%。这与达到2030年90%诊断率和8... | zh-cn |
pair_34517451 | Metabolic-associated fatty liver disease is a hepatic manifestation of systemic metabolic disorders, with a high prevalence. Moreover, it often coexists and evidently interacts with liver injury caused by a variety of viral infections in association with specific bacterial or fungal infectious diseases, and thus united... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 代谢相关脂肪性肝病是全身性代谢紊乱的肝脏表现，其患病率高，除经常与多种病毒感染导致的肝损害共存并相互作用外，还与特定细菌或真菌感染性疾病存在关联，共同影响肝内和肝外临床结局。现对二者合并共存时的相互影响、肝病自然进程和疾病肝外表现等做一阐述。. | zh-cn |
pair_34517452 | Patients with severe alcoholic hepatitis is sensitive to concurrent infection and impact glucocorticoid response and disease prognosis. Glucocorticoids can increase the incidence and of serious infections and fungal infections. Among them, Gram-negative bacterial infections are the major one, and invasive fungal infect... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 重症酒精性肝炎易合并感染，与糖皮质激素的应答及预后相关。糖皮质激素可增加严重感染和真菌感染的发生。其中细菌感染以革兰阴性菌为主，侵袭性真菌感染亦不少见。早期诊断和经验性抗感染治疗是重症酒精性肝炎合并感染的重要手段，在确定多重耐药菌感染的高风险后应及时制定覆盖多重耐药菌的抗感染策略。. | zh-cn |
pair_34517453 | Inherited metabolic liver disease is a wide-range of diseases that cause abnormal metabolism, resulting from genetic defects. Notably, some inherited metabolic liver diseases are closely associated to infection on account of specific substances abnormal metabolism or key enzyme activities deficiency. Therefore, underst... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 遗传代谢性肝病是因基因缺陷导致代谢异常的一大类疾病。一些遗传代谢性肝病由于特定物质代谢异常或关键酶活性缺乏，与感染关系密切。了解遗传代谢性肝病相关感染，有助于指导临床实践、改善患者预后。. | zh-cn |
pair_34517465 | Nucleic acid testing is the gold standard for diagnosing HCV infection, and it is of great significance to guide the treatment of HCV patients and change the follow-up strategy. In recent years, its detection technology has become increasingly mature. This article summarizes the necessity and current status of nucleic ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 核酸检测是丙型肝炎病毒（HCV）感染确诊的金标准，对指导HCV感染者治疗、改变随访策略有重要意义，近年来其检测技术也日益成熟。通过分析国内外文献，对HCV核酸检测必要性和检测现状进行综述，旨在为我国制定消除丙型肝炎的相关政策提供参考性依据。. | zh-cn |
pair_34517466 | Non-alcoholic fatty liver disease has now become a common hepatic metabolic disease, but there is no universally approved therapeutic drug on the market, so there is an urgent need to explore relevant therapeutic drugs. Several studies have shown that the thyroid hormone receptor β, which is specifically expressed in t... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 非酒精性脂肪性肝病现已成为常见的肝脏代谢性疾病，但尚无公认获批的治疗药物上市，探索相关治疗药物迫在眉睫。多项研究结果显示肝脏特异性表达的甲状腺激素受体β在脂质代谢中发挥重要作用。针对甲状腺激素受体β开发的T3类似物和甲状腺激素受体β特异性激动剂，在多个研究结果中显示能抑制肝脏甘油三酯合成，增加肝脏胆固醇清除，减少脂质沉积，同时部分增加胰岛素敏感性，促进糖代谢，改善炎症，成为治疗非酒精性脂肪性肝病极具潜力的治疗药物。现对以甲状腺激素受体β为靶点治疗非酒精性脂肪性肝病的机制、临床研究及药物研发现状进行综述，以期提供治疗非酒精性脂肪性肝病的新思路。. | zh-cn |
pair_34517467 | In recent years, with the changes in living standards and dietary structure, the incidence of non-alcoholic fatty liver disease has been increasing year by year in China, and the incidence rate in the general population is as high as 29.81%. An increasingly epidemiological evidence suggests that non-alcoholic fatty liv... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 近年来，随着生活水平和饮食结构的改变，非酒精性脂肪性肝病的发病率呈逐年上升的趋势，在一般人群中的发病率高达29.81%。越来越多的流行病学证据表明，非酒精性脂肪性肝病已成为日益增长的肝硬化和肝癌的原因之一。但其病因和发病机制复杂，至今尚未完全阐明。构建非酒精性脂肪性肝病合适的动物模型进行临床前研究，对于阐明其发病机制至关重要。现就近年来国内外常见的非酒精性脂肪性肝病动物模型的最新研究进展进行综述。. | zh-cn |
pair_34519120 | The pathogenesis of feline allergic dermatitis (FAD) is unclear, with several differences from allergic dermatitis in dogs and humans. To survey cytokine expression levels in healthy cats and cats affected with allergic dermatitis or asthma. Formalin-fixed, paraffin-embedded skin biopsies from 22 cats with allergic der... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 背景: 猫过敏性皮炎(FAD)的发病机制尚不清楚, 与犬和人过敏性皮炎存在一些差异。 假设/目的: 调查患有过敏性皮炎或哮喘的健康猫和猫的细胞因子表达水平。 动物: 对22只过敏性皮炎猫和21只无过敏性皮炎猫进行皮肤试验, 将皮肤活检组织进行福尔马林固定、石蜡包埋。血清取自17只健康猫、18只过敏性皮炎猫和18只推定诊断为哮喘的猫。 方法和材料: 使用定量PCR[白介素(IL)-31和IL-31受体A]和RNA原位杂交(ISH)[IL-5、IL-31、IL-31RA、IL-33和制瘤素M受体(OSMR)-β]评价皮肤mRNA表达。采用酶联免疫吸附试验评价血清中的IL-31蛋白浓度。使用Luminex试剂盒评价19种其他细胞因子的血清... | zh-cn |
pair_34519120 | The pathogenesis of feline allergic dermatitis (FAD) is unclear, with several differences from allergic dermatitis in dogs and humans. To survey cytokine expression levels in healthy cats and cats affected with allergic dermatitis or asthma. Formalin-fixed, paraffin-embedded skin biopsies from 22 cats with allergic der... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | La pathogénie de la dermatite allergique féline (FAD) n’est pas claire, avec plusieurs différences par rapport à la dermatite allergique de l’homme et du chien. HYPOTHÈSES/OBJECTIFS: Etudier le niveau d’expression des cytokines chez les chats sains et les chats atteints de dermatite allergique ou d’asthme. Des biopsies... | fr |
pair_34519120 | The pathogenesis of feline allergic dermatitis (FAD) is unclear, with several differences from allergic dermatitis in dogs and humans. To survey cytokine expression levels in healthy cats and cats affected with allergic dermatitis or asthma. Formalin-fixed, paraffin-embedded skin biopsies from 22 cats with allergic der... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Die Pathogenese der felinen allergischen Dermatitis (FAD) ist unklar, wobei einige Unterschiede zur allergischen Dermatitis von Hunden und Menschen bestehen. Ein Überblick über die Zytokin Exprimierung von gesunden Katzen und Katzen mit allergischer Dermatitis oder Asthma. In Formalin-fixierte und in Paraffin-eingebett... | de |
pair_34519120 | The pathogenesis of feline allergic dermatitis (FAD) is unclear, with several differences from allergic dermatitis in dogs and humans. To survey cytokine expression levels in healthy cats and cats affected with allergic dermatitis or asthma. Formalin-fixed, paraffin-embedded skin biopsies from 22 cats with allergic der... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | A patogênese da dermatite alérgica felina (DAF) não é clara, apresentando várias diferenças em comparação com a dermatite alérgica em cães e humanos. HIPÓTESE/OBJETIVOS: Estudar os níveis de expressão de citocinas em gatos saudáveis e gatos afetados por dermatite alérgica ou asma. Amostras de biópsia parafinadas e fixa... | pt |
pair_34519120 | The pathogenesis of feline allergic dermatitis (FAD) is unclear, with several differences from allergic dermatitis in dogs and humans. To survey cytokine expression levels in healthy cats and cats affected with allergic dermatitis or asthma. Formalin-fixed, paraffin-embedded skin biopsies from 22 cats with allergic der... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | la patogenia de la dermatitis alérgica felina (FAD) no está clara, con varias diferencias con la dermatitis alérgica en perros y seres humanos. HIPÓTESIS/OBJETIVOS: Estudiar los niveles de expresión de citoquinas en gatos sanos y gatos afectados por dermatitis alérgica o asma. ANIMALES: para los ensayos cutáneos se uti... | es |
pair_34519121 | A defective skin barrier occurs in dogs with atopic dermatitis, and there is controversy over whether this defect pre-exists, or is secondary to allergic inflammation. To study if an allergen challenge decreases the natural moisturising factor (NMF), which contains the main filaggrin degradation products. Four house du... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 背景: 特应性皮炎犬的皮肤屏障存在缺陷, 对于该缺陷是预先存在还是继发于过敏性炎症存在争议。 目的: 研究过敏原激发是否会降低含有主要丝聚蛋白降解产物的天然保湿因子(NMF)。 动物: 来自一个研究种群的4只屋尘螨(HDM)致敏的成年特应性犬。 方法: 在犬右侧腹部用HDM进行皮外激发, 同时左胸作为对照。我们在激发前和激发后第(D)1、D2、D3、D7和D28天, 在两个选定部位擦拭皮肤表面; 将拭子浸泡在洗涤剂中并冷冻直至测定。通过液相色谱-串联质谱法(LC/MS-MS)测定NMF组分。 结果: 过敏原激发在用药部位引起中度皮肤病变, 在对照区域也引起轻度红斑。过敏原激发导致两个位点的总NMF及其组分反式尿烷酸(t-UCA)、吡... | zh-cn |
pair_34519121 | A defective skin barrier occurs in dogs with atopic dermatitis, and there is controversy over whether this defect pre-exists, or is secondary to allergic inflammation. To study if an allergen challenge decreases the natural moisturising factor (NMF), which contains the main filaggrin degradation products. Four house du... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Un défaut de barrière cutanée existe chez le chien atopique et il y a controverse si ce défaut préexiste ou s’il est secondaire à une inflammation allergique. Etudier si une provocation allergénique diminue le NMF (natural moisturising factor) qui contient les principaux produits de dégradation de la filaggrine. Quatre... | fr |
pair_34519121 | A defective skin barrier occurs in dogs with atopic dermatitis, and there is controversy over whether this defect pre-exists, or is secondary to allergic inflammation. To study if an allergen challenge decreases the natural moisturising factor (NMF), which contains the main filaggrin degradation products. Four house du... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Bei Hunden mit atopischer Dermatitis besteht eine defekte Hautbarriere und es besteht eine Kontroverse darüber, ob dieser Defekt wirklich vor-existiert oder ob er sekundär durch die allergische Entzündung verursacht wird. Es sollte untersucht werden, ob eine Provokation mit dem Allergen den natürlichen Feuchthalte-Fakt... | de |
pair_34519121 | A defective skin barrier occurs in dogs with atopic dermatitis, and there is controversy over whether this defect pre-exists, or is secondary to allergic inflammation. To study if an allergen challenge decreases the natural moisturising factor (NMF), which contains the main filaggrin degradation products. Four house du... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Defeitos de barreira cutânea ocorrem em cães com dermatite atópica, e há controvérsias se esse defeito é pré-existente, ou secundário à inflamação alérgica. Estudar se um desafio alergênico é capaz reduzir o fator hidratante natural (NMF), que contém os principais produtos de degradação de filagrina. Quatro cães atópic... | pt |
pair_34519121 | A defective skin barrier occurs in dogs with atopic dermatitis, and there is controversy over whether this defect pre-exists, or is secondary to allergic inflammation. To study if an allergen challenge decreases the natural moisturising factor (NMF), which contains the main filaggrin degradation products. Four house du... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | en perros con dermatitis atópica se observa una barrera cutánea defectuosa, y existe controversia sobre si este defecto existe antes o es secundario a la inflamación alérgica. OBJETIVOS: Estudiar si una exposición con alérgenos disminuye el factor de hidratación natural (NMF), que contiene los principales productos de ... | es |
pair_34519123 | The pathogenesis of human atopic dermatitis (AD) is complex. Like humans, dogs develop spontaneous AD so this species could be a useful model of study. However, AD has been less characterised in dogs than in humans. To compare the epidermis of normal and spontaneously atopic dogs at the functional and structural levels... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 背景: 人类特应性皮炎(AD)的发病机制复杂。与人类一样, 犬也会出现自发性AD, 因此该物种可能是有用的研究模型。然而, 犬中的AD特征少于人。 目的: 在功能和结构水平上, 比较正常和自发性特应性犬的表皮。 动物: 6只健康和5只特应性实验室比格犬。 方法和材料: 通过全身检查、犬特应性皮炎程度和严重指数、第4版(CADESI-04)评价和经表皮水分流失(TWEL)测量对犬进行临床表征。从正常犬的健康皮肤以及特应性犬的非病变和病变皮肤上进行皮肤活检。使用透射电子显微镜(TEM)分析样品。提取角化包膜并检查其外观 (平滑与褶皱) 。 结果: CADESI-04和TWEL在特应性犬中显著较高。通过组织病理学评估可区分健康和非病变皮肤... | zh-cn |
pair_34519123 | The pathogenesis of human atopic dermatitis (AD) is complex. Like humans, dogs develop spontaneous AD so this species could be a useful model of study. However, AD has been less characterised in dogs than in humans. To compare the epidermis of normal and spontaneously atopic dogs at the functional and structural levels... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | La pathogénie de la dermatite atopique de l’homme (AD) est complexe. Comme l’homme, le chien développe une AD spontanée, cette espèce pourrait donc être un modèle d’étude utile. Cependant l’AD a été moins caractérisée chez le chien que chez l’homme. Comparer l’épiderme de chiens sains et spontanément atopiques au nivea... | fr |
pair_34519123 | The pathogenesis of human atopic dermatitis (AD) is complex. Like humans, dogs develop spontaneous AD so this species could be a useful model of study. However, AD has been less characterised in dogs than in humans. To compare the epidermis of normal and spontaneously atopic dogs at the functional and structural levels... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Die Pathogenese der atopischen Dermatitis (AD) des Menschen ist komplex. Wie der Mensch entwickeln auch Hunde spontan AD, daher könnte diese Spezies ein nützliches Modell zur Untersuchung darstellen. Die AD ist jedoch beim Hund weniger genau beschrieben wie beim Menschen. Ein Vergleich der Epidermis von normalen und sp... | de |
pair_34519123 | The pathogenesis of human atopic dermatitis (AD) is complex. Like humans, dogs develop spontaneous AD so this species could be a useful model of study. However, AD has been less characterised in dogs than in humans. To compare the epidermis of normal and spontaneously atopic dogs at the functional and structural levels... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | A patogênese da dermatite atópica humana (DA) é complexa. Como seres humanos, os cães desenvolvem DA espontaneamente o que torna esta espécie um modelo útil de estudo. No entanto, DA foi tem sido menos caracterizada em cães do que em humanos. Comparar a epiderme de cães normais e espontaneamente atópicos nos níveis fun... | pt |
pair_34519123 | The pathogenesis of human atopic dermatitis (AD) is complex. Like humans, dogs develop spontaneous AD so this species could be a useful model of study. However, AD has been less characterised in dogs than in humans. To compare the epidermis of normal and spontaneously atopic dogs at the functional and structural levels... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | la patogenia de la dermatitis atópica en seres humanos (AD) es compleja. Al igual que en humanos, los perros desarrollan AD espontánea, por lo que esta especie podría ser un modelo de estudio útil. Sin embargo, la AD se ha caracterizado menos en perros que en humanos. Comparar la epidermis de perros normales y espontán... | es |
pair_34519392 | The involvement of interleukin (IL)-33 produced by keratinocytes has been suggested in the pathogenesis of canine atopic dermatitis (cAD). House dust mite (HDM)-derived proteases induce the production of various cytokines and chemokines in keratinocytes via protease-activated receptor-2 (PAR-2); however, their effects ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 背景: 角质细胞产生的白介素(IL)-33参与了犬特应性皮炎(cAD)的发病机制。屋尘螨(HDM)衍生的蛋白酶通过蛋白酶激活受体-2(PAR-2)诱导角质细胞产生各种细胞因子和趋化因子; 然而, 尚未确定其对犬角质细胞中IL-33 mRNA表达的影响。 假设/目的: 阐明HDM衍生的蛋白酶是否通过PAR-2诱导犬角质细胞表达IL-33 mRNA。 方法和材料: 用粉尘螨(Der f)全身提取物、用半胱氨酸蛋白酶和丝氨酸蛋白酶抑制剂预处理的Der f, 以及用胰蛋白酶预处理的Der f刺激的犬祖细胞表皮角质细胞(CPEK)的细胞系, 并通过实时PCR定量IL-33 mRNA的表达。在用PAR-2拮抗剂处理的CPEK细胞中也测定了胰蛋白... | zh-cn |
pair_34519392 | The involvement of interleukin (IL)-33 produced by keratinocytes has been suggested in the pathogenesis of canine atopic dermatitis (cAD). House dust mite (HDM)-derived proteases induce the production of various cytokines and chemokines in keratinocytes via protease-activated receptor-2 (PAR-2); however, their effects ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | L’implication de l’interleukine (IL)-33 produite par les kératinocytes a été suggérée dans la pathogénie de la dermatite atopique canine (cAD). Les protéases dérivées des acariens de poussière de maison (HDM) induisent la production de cytokines et chimiokines variées dans les kératinocytes via PAR-2 (protease-activate... | fr |
pair_34519392 | The involvement of interleukin (IL)-33 produced by keratinocytes has been suggested in the pathogenesis of canine atopic dermatitis (cAD). House dust mite (HDM)-derived proteases induce the production of various cytokines and chemokines in keratinocytes via protease-activated receptor-2 (PAR-2); however, their effects ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Eine Beteiligung von Interleukin (IL)-31, welches von Keratinozyten produziert wird, an der Pathogenese der atopischen Dermatitis des Hundes (cAD), wird vermutet. Proteasen aus Hausstaubmilben (HDM) induzieren die Produktion verschiedener Zytokine und Chemokine in Keratinozyten über den Protease-Activated Rezeptor-2 (P... | de |
pair_34519392 | The involvement of interleukin (IL)-33 produced by keratinocytes has been suggested in the pathogenesis of canine atopic dermatitis (cAD). House dust mite (HDM)-derived proteases induce the production of various cytokines and chemokines in keratinocytes via protease-activated receptor-2 (PAR-2); however, their effects ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | O envolvimento da interleucina (IL) -33 produzido por queratinócitos tem sido sugerido na patogênese da dermatite atópica canina (CAD). As proteases derivadas de ácaros da poeira doméstica (HDM) induz a produção de várias citocinas e quimiocinas por queratinócitos via receptor-2 ativado por protease (PAR-2); Entretanto... | pt |
pair_34519392 | The involvement of interleukin (IL)-33 produced by keratinocytes has been suggested in the pathogenesis of canine atopic dermatitis (cAD). House dust mite (HDM)-derived proteases induce the production of various cytokines and chemokines in keratinocytes via protease-activated receptor-2 (PAR-2); however, their effects ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | Se ha sugerido la participación de la interleuquina (IL) -33 producida por los queratinocitos en la patogenia de la dermatitis atópica canina (cAD). Las proteasas derivadas de ácaros del polvo doméstico (HDM) inducen la producción de diversas citoquinas y quimioquinas en los queratinocitos a través del receptor 2 activ... | es |
pair_34521189 | Immune checkpoint inhibitors (ICIs) is a negative regulatory factor antibody, which activates T cells to play an anti-tumor effect in immunotherapy, and can also cause immune-related adverse responses, thereby inducing a series of immune related adverse events (irAEs). Among these irAEs, although the incidence of ICIs-... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 【中文题目：免疫检查点抑制剂相关心肌炎的研究进展】 【中文摘要：免疫检查点抑制剂（immune checkpoint inhibitors, ICIs）是一种负性调节因子抗体，激活T细胞发挥免疫治疗抗肿瘤作用的同时，也可引起免疫相关的不良应答，从而诱导出一系列免疫相关不良反应（immune related adverse events, irAEs）。在这些irAEs中，ICIs相关心肌炎的发病率虽然很低，但致死率却明显高于其他不良反应，接近50%，临床医生应用ICIs时应提高警惕，但目前ICIs相关心肌炎的发病机制仍不明确。本文结合近期ICIs的研究成果对ICIs相关性心肌炎的发生机制及临床表现等方面作一综述，以提高临床医生对该不... | zh-cn |
pair_34521190 | Lung cancer is a malignant tumor with high incidence rate and mortality rate in China and even the whole world, of which non-small cell lung cancer accounts for about 80%. Anaplastic lymphoma kinase (ALK) gene mutation accounts for about 5%. Alectinib, ALK-tyrosine kinase inhibitor (ALK-TKI), has great performance in c... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 【中文题目：阿来替尼治疗ALK阳性非小细胞肺癌：
1例报告及文献复习】 【中文摘要：肺癌是我国乃至全球发病率及死亡率均较高的恶性肿瘤，其中非小细胞肺癌占80%左右，间变性淋巴瘤激酶（anaplastic lymphoma kinase, ALK）基因突变的患者约占5%。ALK抑制剂阿来替尼的疗效优异，药物治疗不良反应的及时发现、及早治疗能极大地提高患者的临床获益。现报道包头市中心医院2020年4月收治的1例ALK阳性非小细胞肺癌的诊断、治疗及药物副反应处理，并文献复习。
】 【中文关键词：间变性淋巴瘤激酶；肺肿瘤；阿来替尼；不良反应】. | zh-cn |
pair_34523270 | To summarize the patterns and research progress of the concomitant ipsilateral fractures of intracapsular femoral neck and extracapsular trochanter, and to provide a common language among orthopedic surgeons for scientific exchange. According to related literature and authors own experiences concerning the anatomic bor... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 总结同时累及同侧股骨颈与转子间两个解剖区域骨折的相关研究进展，归纳骨折分型。. 查阅国内外相关文献并结合自身经验，从股骨颈与转子间的解剖分界、股骨转子间线及关节囊附着、临床分型、治疗方法选择等方面进行分析总结。. 同时累及同侧股骨颈与转子间两个解剖区域的股骨近端粉碎骨折，在老年髋部骨折人群中比例有逐渐增高趋势，但其概念和含义并不明确。按股骨颈骨折的部位、骨折中心位置和骨折复位后股骨距或前内下角皮质能否直接接触砥住，可以将其分为 3 种亚型：① 节段性股骨颈骨折（股骨颈为头下型骨折，同时具有两个独立的骨折中心）；② 股骨颈骨折向转子间外上方延伸（股骨颈为经颈型骨折，一个骨折中心）；③ 股骨转子间粉碎骨折向股骨颈内下方延伸（粉碎的股骨颈... | zh-cn |
pair_34523271 | To formulate the classification criteria of femoral intertrochanteric fractures based on irreducibility or not in order to predict the difficulty of fracture recovery. A clinical data of 244 patients with closed femoral intertrochanteric fractures admitted between January 2017 and March 2020 was retrospectively analyze... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 制定基于难复与否的股骨转子间骨折分型标准，为术前预判股骨转子间骨折复位难易程度提供参考标准。. 回顾性分析 2017 年 1 月—2020 年 3 月收治的 244 例闭合性股骨转子间骨折患者临床资料。男 116 例，女 128 例；年龄 45～100 岁，平均 77.9 岁。致伤原因：摔伤 190 例，交通事故伤 36 例，砸伤 13 例，高处坠落伤 5 例。受伤至手术时间 1～14 d，平均 3.6 d。根据国际内固定研究协会/美国骨创伤协会（AO/OTA）分型标准：31-A1 型 38 例，31-A2 型 160 例，31-A3 型 46 例。根据术中闭合牵引复位是否困难，将患者分为易复位组和难复位组；结合文献以及两组患者术前... | zh-cn |
pair_34523272 | To investigate the morphology of coronal femoral intertrochanteric fracture and its effect on reduction and internal fixation. The clinical and imaging data of 46 patients with femoral intertrochanteric fracture who met the selection criteria between August 2017 and October 2018 were reviewed. There were 15 males and 3... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 研究股骨转子间冠状位骨折形态，并探讨其对复位内固定技术的影响。. 回顾分析 2017 年 8 月—2018 年 10 月收治的符合选择标准的 46 例股骨转子间骨折患者临床及影像学资料。男 15 例，女 31 例；年龄 62～91 岁，平均 72.8 岁。致伤原因：行走摔伤 35 例，坠床致伤 4 例，交通事故伤 7 例。国际内固定研究协会/美国骨创伤协会（AO/OTA）分型为 31-A1 型 11 例，31-A2 型 35 例。所有患者均行闭合复位髓内钉内固定，术中根据术前评估结果进行骨折复位与固定。根据患者术前 X 线片和 CT 三维重建图像，观察股骨转子间冠状位骨折线的走向和骨折块形态特征；并对不同 AO/OTA 分型的骨折进... | zh-cn |
pair_34523273 | To investigate the mid-term effectiveness of periacetabular osteotomy (PAO) through modified ilioinguinal approach for acetabular dysplasia in adults. Between January 2016 and December 2018, 39 patients (43 hips) with acetabular dysplasia who met the selection criteria were enrolled in the study and their clinical data... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 探讨经改良髂腹股沟入路行髋臼周围截骨术（periacetabular osteotomy，PAO）治疗成人髋臼发育不良的中期疗效。. 回顾分析 2016 年 1 月—2018 年 12 月收治且符合选择标准的 39 例（43 髋）髋臼发育不良患者临床资料，均经改良髂腹股沟入路（首先以传统髂腹股沟入路切开皮肤和浅筋膜，深层采用改良髂股入路）行 PAO 治疗。其中男 3 例（3 髋），女 36 例（40 髋）；年龄 18～51 岁，平均 36 岁。单髋 35 例，双髋 4 例。病程 4～96 个月，中位数 18 个月。改良 Tönnis 骨关节炎分期，0 期 35 髋、Ⅰ期 6 髋、Ⅱ期 2 髋。患者均有不同程度髋关节疼痛，术前疼痛视觉... | zh-cn |
pair_34523274 | To explore the different imaging manifestations of osteonecrosis of the femoral head (ONFH) and their correlation with the occurrence of pain during the peri-collapse period. The 372 patients (624 hips) with ONFH in the peri-collapse stage who were admitted between December 2016 and October 2019 and met the selection c... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 探讨围塌陷期股骨头坏死（osteonecrosis of the femoral head，ONFH）的影像学表现及与疼痛发生的相关性。. 以 2016 年 12 月—2019 年 10 月收治且符合选择标准的 372 例（624 髋）围塌陷期 ONFH 患者作为研究对象。其中男 270 例，女 102 例；年龄 15～65 岁，平均 35.3 岁。单髋 120 例，双髋 252 例。ONFH 类型：创伤性 39 例（39 髋）、激素性 196 例（346 髋）、酒精性 102 例（178 髋）、特发性 35 例（61 髋）。其中，有疼痛症状 482 髋，疼痛时间≤3 个月 212 髋、3～6 个月 124 髋、6～12 个月 11... | zh-cn |
pair_34523275 | To compare the effectiveness of the femoral neck system (FNS) and inverted triangle cannulated screws (ITCS) for the treatment of Pauwels type Ⅲ femoral neck fractures. The clinical data of 59 patients with Pauwels type Ⅲ femoral neck fractures treated between May 2019 and November 2020 were retrospectively analysed. T... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 比较股骨颈动力交叉钉系统（femoral neck system，FNS）和倒三角空心钉（inverted triangle cannulated screws，ITCS）治疗 Pauwels Ⅲ型股骨颈骨折的临床疗效。. 回顾分析 2019 年 5 月—2020 年 11 月收治的 59 例 Pauwels Ⅲ型股骨颈骨折患者临床资料，根据内固定方式不同分为 FNS 组（28 例）和 ITCS 组（31 例）。两组患者性别、年龄、侧别、身体质量指数、致伤原因、吸烟史、酗酒史、Pauwels 角、Garden 分型、国际内固定研究协会/美国骨创伤协会（AO/OTA）分型及受伤至手术时间等一般资料比较差异均无统计学意义（ <i>P</... | zh-cn |
pair_34523277 | To compare the effectiveness of unicompartmental knee arthroplasty (UKA) and total knee arthroplasty (TKA) in the treatment of severe medial compartment osteoarthritis (OA). A clinical data of 69 patients (69 knees), who underwent joint replacement due to severe medial compartment OA between February 2015 and September... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 比较单髁关节置换术（unicompartmental knee arthroplasty，UKA）和全膝关节置换术（total knee arthroplasty，TKA）治疗膝关节内侧间室重度骨关节炎（osteoarthritis，OA）的疗效。. 回顾分析 2015 年 2 月—2018 年 9 月，69 例（69 膝）因膝关节内侧间室重度 OA 接受关节置换术且符合选择标准的患者临床资料。其中，UKA 治疗 38 例（UKA 组），TKA 治疗 31 例（TKA 组）。两组患者性别、年龄、身体质量指数、病程、病变侧别以及术前疼痛视觉模拟评分（VAS）、美国特种外科医院（HSS）评分、美国西部 Ontario 与 McMaste... | zh-cn |
pair_34523279 | To investigate the effectiveness of arthroscopic 360° capsular release for frozen shoulder. Between April 2018 and April 2019, 42 patients with frozen shoulders were treated with arthroscopic 360° capsular release. There were 13 males and 29 females, with an average age of 52.3 years (range, 45-56 years). There were 14... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 探讨关节镜下 360° 关节囊松解治疗冻结肩的疗效。. 2018 年 4 月—2019 年 4 月，采用关节镜下 360° 关节囊松解治疗 42 例冻结肩患者。男 13 例，女 29 例；年龄 45～56 岁，平均 52.3 岁。左肩 14 例，右肩 28 例。病程 5～18 个月，平均 11.1 个月。主要临床症状为肩关节主、被动活动受限伴严重疼痛。所有患者均排除肩峰撞击综合征及肩关节骨关节炎。术前肩关节活动度为前屈（93.2±15.4）°、体侧外旋（15.9±6.0）°、外展 90° 外旋（18.4±9.9）°，以及内旋达股骨大转子 5 例、臀部 20 例、S <sub>1</sub> 水平 17 例。疼痛视觉模拟评分（VAS）... | zh-cn |
pair_34523281 | To investigate the effectiveness of synchronous unilateral percutaneous kyphoplasty (PKP) in the treatment of double noncontiguous thoracolumbar osteoporotic vertebral compression fracture (OVCF). Between December 2018 and September 2020, 27 patients with double noncontiguous thoracolumbar OVCF were treated by synchron... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 探讨同步单侧穿刺经皮椎体后凸成形术（percutaneous kyphoplasty，PKP）治疗胸腰椎跳跃型双节段骨质疏松性椎体压缩骨折（osteoporotic vertebral compression fracture，OVCF）的疗效。. 2018 年 12 月—2020 年 9 月，采用同步单侧穿刺 PKP 治疗 27 例胸腰椎跳跃型双节段 OVCF。其中男 11 例，女 16 例；年龄 66～92 岁，平均 75.4 岁。致伤原因：摔伤 22 例，扭伤 5 例。受伤至入院时间 0.5～7.0 d，平均 2.1 d。骨折椎体节段：T <sub>9</sub> 2 个，T <sub>10</sub> 3 个，T <sub>... | zh-cn |
pair_34523282 | To compare the refracture risk between sandwich vertebrae and ordinary adjacent vertebrae, and to explore the risk factors related to refracture. Retrospective analysis was performed on the data of patients who received percutaneous vertebral augmentation (PVA) and formed sandwich vertebrae between April 2015 and Octob... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 比较夹心椎与普通邻椎的再骨折风险，探讨再骨折相关危险因素。. 回顾性分析 2015 年 4 月—2019 年 10 月采用椎体强化术治疗并形成夹心椎的患者临床资料，其中 115 例符合选择标准纳入研究。男 27 例，女 88 例；年龄 53～89 岁，平均 73.9 岁。单因素分析患者一般资料、椎体强化术相关指标以及夹心椎相关指标；对患者 T <sub>4</sub>～L <sub>5</sub> 范围内夹心椎与普通邻椎从椎体水平进行生存分析，比较夹心椎与普通邻椎再骨折风险曲线及不发生再骨折的概率，并以 Cox 比例风险回归模型分析再骨折危险因素。. 115 例患者椎体强化术后获随访 12.6～65.9 个月，平均 36.2 个月。... | zh-cn |
pair_34523283 | To investigate the effects of gender and age on the posterior cranial fossa linear volume and cerebellar tonsil position in normal populations. A total of 180 normal adults who underwent cervical MRI examination at the physical examination center were selected, including 90 males and 90 females; the age ranged from 20 ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 探讨性别及年龄对正常成人后颅窝线性容积及小脑扁桃体下缘位置的影响。. 选取体检中心行颈椎 MRI 检查的正常成人 180 例，男 90 例，女 90 例；年龄 20～79 岁，平均 50.4 岁。由 2 名脊柱外科医师于颈椎 MRI T2 加权像正中矢状位层面上行后颅窝线性容积及小脑扁桃体下缘位置影像学测量。后颅窝线性容积指标包括：斜坡长度（AB）、枕骨大孔前后径（BC）、枕骨鳞部长度（CD）、后颅窝矢状径（DA）、后颅窝高径（BE）、斜坡倾斜角（∠α）；小脑扁桃体下缘位置指标为 MN，即小脑扁桃体下缘至基线的距离。比较男女性别组间各指标差异，并行 Pearson 相关分析年龄与各指标的关系。. 后颅窝线性容积指标 AB、BC、CD... | zh-cn |
pair_34523284 | To explore the effectiveness of the modified designed bilobed latissimus dorsi myocutaneous flap in chest wall reconstruction of locally advanced breast cancer (LABC) patients. Between January 2016 and June 2019, 64 unilateral LABC patients were admitted. All patients were female with an average age of 41.3 years (rang... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 探讨优化设计分叶背阔肌皮瓣修复局部晚期乳腺癌术后胸壁缺损的效果。. 2016 年 1 月—2019 年 6 月，收治 64 例单侧局部晚期乳腺癌女性患者。患者年龄 34～50 岁，平均 41.3 岁。病程 6～32 个月，平均 12.3 个月。原发肿瘤直径 4.8～14.2 cm，平均 8.59 cm。首先行乳腺癌改良根治术/根治术，遗留胸壁皮肤软组织缺损范围为 16 cm×15 cm～20 cm×20 cm；采用顺行法（34 例）或逆行法（30 例）设计并切取分叶背阔肌皮瓣移植修复缺损，皮岛切取范围为 13 cm×5 cm～17 cm×6 cm；皮瓣供区均直接闭合。. 术后 2 例（5.8%，2/34）顺行皮瓣、6 例（20%，6... | zh-cn |
pair_34523285 | To explore the effectiveness of free-style perforator pedicled propeller flap to repair the wound after extensive resection of skin malignant tumor on the thigh. Between December 2016 and June 2019, 12 patients with skin malignant tumor on the thigh were treated. There were 9 males and 3 females, aged from 8 to 65 year... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 探讨自由式穿支蒂螺旋桨皮瓣修复大腿皮肤软组织恶性肿瘤扩大切除后创面的疗效。. 2016 年 12 月—2019 年 6 月，收治 12 例大腿皮肤软组织恶性肿瘤患者。男 9 例，女 3 例，年龄 8～65 岁，中位数 38.5 岁。其中皮肤基底细胞癌 3 例，鳞状细胞癌 7 例，纤维肉瘤 1 例，黑色素瘤 1 例。病程 5 个月～10 年，中位数 7.5 年。术前应用彩色多普勒超声探测并标记至少 1 条穿支血管备用。术中行肿瘤扩大切除后，遗留创面范围为 5.0 cm×3.5 cm～8.5 cm×6.5 cm。在病灶缘 1～3 cm 范围自深筋膜深面再次探查确认穿支血管并标记，以距离病灶缘最近、口径>0.5 mm 的穿支血管为皮瓣旋转... | zh-cn |
pair_34523286 | To explore the feasibility and effectiveness of free transplantation of medial plantar Flow-through venous flap for primary repairing children's finger wounds with digital artery defect. Between July 2016 and October 2020, 9 children who suffered finger wounds with digital artery defect were primary repaired with free ... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 探讨足底内侧 Flow-through 静脉皮瓣游离移植一期修复儿童指动脉缺损创面的可行性和临床效果。. 2016 年 7 月—2020 年 10 月，采用足底内侧 Flow-through 静脉皮瓣游离移植一期修复儿童指动脉缺损创面 9 例。男 6 例，女 3 例；年龄 4～13 岁，平均 6.8 岁。致伤原因：重物压砸伤 5 例，绞伤 4 例。其中示指 3 例，中指 3 例，环指 2 例，小指 1 例。创面范围为 1.8 cm×1.5 cm～4.0 cm×2.5 cm。受伤至手术时间 1.3～8.6 h，平均 4.8 h。皮瓣切取范围为 2.0 cm×1.6 cm～4.2 cm×2.6 cm。9 例皮瓣倒置后均采用静脉桥接指动脉... | zh-cn |
pair_34523287 | The incidence of primary malignant bone tumors is low, and clinical cognition is insufficient. The establishment of diagnostic criteria is of great significance for prognosis of tumors. National Comprehensive Cancer Network (NCCN) regularly publishes 'Clinical Practice Guidelines for Bone Tumors' to summarize the lates... | en | lexi-ml/wmt_22_dataset_en_zh-cn | train | text | 原发性恶性骨肿瘤发病率较低，临床认知存在不足，形成诊疗规范对促进疾病预后意义重大。美国国家综合癌症网络（NCCN）会定期发布《骨肿瘤临床实践指南》，总结骨肿瘤的最新治疗进展。在 2020 年 11 月最新发布的指南中描述，软骨肉瘤、脊索瘤和骨巨细胞瘤治疗以手术为主，可联合放疗或靶向治疗；Ewing 肉瘤和骨肉瘤采用手术联合化疗的综合治疗；免疫治疗可用于治疗骨高级别未分化多形性肉瘤。对于复发性肿瘤，可以采用手术联合放疗、化疗或靶向治疗进行控制。新版指南为骨肿瘤的规范治疗提供了参考依据。. | zh-cn |
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