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2,669 | Frontiers in antiviral therapy and immunotherapy
https://doi.org/10.1002/cti2.1115
SHA: facbfdfa7189ca9ff83dc30e5d241ab22e962dbf
Authors: Heaton, Steven M
Date: 2020
DOI: 10.1002/cti2.1115
License: cc-by
Abstract: nan
Text: Globally, recent decades have witnessed a growing disjunction, a 'Valley of Death' 1,2 no l... | What has CRISPR/Cas antiviral immune system of prokaryotes been repurposed as? | false | 4,163 | {
"text": [
"as a revolutionary gene-editing biotechnology in plants and animals."
],
"answer_start": [
7513
]
} |
2,504 | Respiratory Viral Infections in Exacerbation of Chronic Airway Inflammatory Diseases: Novel Mechanisms and Insights From the Upper Airway Epithelium
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7052386/
SHA: 45a566c71056ba4faab425b4f7e9edee6320e4a4
Authors: Tan, Kai Sen; Lim, Rachel Liyu; Liu, Jing; Ong, Hsiao Hui; ... | What do the acute exacerbations cause? | false | 3,867 | {
"text": [
"morbidity and sometimes mortality in patients, as well as resulting in major economic burdens worldwide"
],
"answer_start": [
3168
]
} |
2,504 | Respiratory Viral Infections in Exacerbation of Chronic Airway Inflammatory Diseases: Novel Mechanisms and Insights From the Upper Airway Epithelium
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7052386/
SHA: 45a566c71056ba4faab425b4f7e9edee6320e4a4
Authors: Tan, Kai Sen; Lim, Rachel Liyu; Liu, Jing; Ong, Hsiao Hui; ... | What are IFV infection shown to do? | false | 4,015 | {
"text": [
"increase miR-125a and b, and miR-132 in COPD epithelium which inhibits A20 and MAVS; and p300 and IRF3, respectively, resulting in increased susceptibility to viral infections"
],
"answer_start": [
30018
]
} |
1,628 | Evidence for the Convergence Model: The Emergence of Highly Pathogenic Avian Influenza (H5N1) in Viet Nam
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4580613/
SHA: ee5b43d20a640664510cb7a540caaae4a8e19933
Authors: Saksena, Sumeet; Fox, Jefferson; Epprecht, Michael; Tran, Chinh C.; Nong, Duong H.; Spencer, James H.;... | How does land use fragmentation increase the risk of flu-like diseases? | false | 594 | {
"text": [
"Landscape fragmentation produces ecotones, defined as abrupt edges or transitions zones between different ecological systems, thought to facilitate disease emergence by increasing the intensity and frequency of contact between host species [31] Furthermore, fragmentation of natural habitat tends to i... |
1,571 | Community-acquired pneumonia in children — a changing spectrum of disease
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608782/
SHA: eecb946b106a94f26a79a964f0160e8e16f79f42
Authors: le Roux, David M.; Zar, Heather J.
Date: 2017-09-21
DOI: 10.1007/s00247-017-3827-8
License: cc-by
Abstract: Pneumonia remains the lea... | What is the effect of childhood tuberculosis in childhood pneumonia? | false | 536 | {
"text": [
"A recent systematic review of tuberculosis as a comorbidity of childhood pneumonia reported culture-confirmed disease in about 8% of cases [50] . Because intrathoracic tuberculosis disease is only culture-confirmed in a minority of cases, the true burden could be even higher; tuberculosis could there... |
1,595 | Severe Acute Respiratory Syndrome Coronavirus Viroporin 3a Activates the NLRP3 Inflammasome
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361828/
SHA: f02d0c1e8b0109648e578662dc250abe349a033c
Authors: Chen, I-Yin; Moriyama, Miyu; Chang, Ming-Fu; Ichinohe, Takeshi
Date: 2019-01-29
DOI: 10.3389/fmicb.2019.00050
Licens... | Where does the NLRP3 inflammasome activate after a SARS-CoV infection? | false | 280 | {
"text": [
"in lipopolysaccharide-primed macrophages"
],
"answer_start": [
889
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} |
2,684 | 1918 Influenza: the Mother of All Pandemics
Jeffery K. Taubenberger" and David M. Morens1-
The “Spanish" influenza pandemic of 1918—1919,
which caused :50 million deaths worldwide, remains an
ominous warning to public health. Many questions about its
origins, its unusual epidemiologic features, and the basis of
its p... | What descendant lineages of the swine flu (Spanish Influenza) virus were identified in 2006? | false | 1,068 | {
"text": [
"2 major descendant lineages of the 1918\nH1N1 Virus, as well as 2 additional reassortant lineages,\npersist naturally: a human epidemic/endemic H1N1 line-\nage, a porcine enzootic H1N1 lineage (so-called classic\nswine flu), and the reassorted human H3N2 Virus lineage,\nwhich like the human H1N1 Virus... |
185 | CDC Summary 21 MAR 2020,
https://www.cdc.gov/coronavirus/2019-ncov/cases-updates/summary.html
This is a rapidly evolving situation and CDC will provide updated information and guidance as it becomes available.
Updated March 21, 2020
CDC is responding to a pandemic of respiratory disease spreading from person-to-pers... | What are the phases of a pandemic? | false | 233 | {
"text": [
"investigation phase, followed by recognition, initiation, and acceleration phases"
],
"answer_start": [
7253
]
} |
1,592 | Pretreatment Hepatitis C Virus NS5A/NS5B Resistance-Associated Substitutions in Genotype 1 Uruguayan Infected Patients
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6112080/
SHA: f01ad3545245b4f884b48aa2b69c9deb942c3e77
Authors: Aldunate, Fabián; Echeverría, Natalia; Chiodi, Daniela; López, Pablo; Sánchez-Cicerón, Ad... | Was written consent obtained? | false | 3,899 | {
"text": [
"was obtained"
],
"answer_start": [
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} |
2,486 | Potential Rapid Diagnostics, Vaccine and Therapeutics for 2019 Novel Coronavirus (2019-nCoV): A Systematic Review
https://doi.org/10.3390/jcm9030623
SHA: 9b0c87f808b1b66f2937d7a7acb524a756b6113b
Authors: Pang, Junxiong; Wang, Min Xian; Ang, Ian Yi Han; Tan, Sharon Hui Xuan; Lewis, Ruth Frances; Chen, Jacinta I. Pei;... | What are roles of the period and type of specimens? | false | 3,633 | {
"text": [
"It was found that the respiratory specimens were positive for the virus while serum was negative in the early period. It has also suggested that in the early days of illness, patients have high levels of virus despite the mild symptoms."
],
"answer_start": [
7413
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} |
2,683 | Estimating the number of infections and the impact of non-
pharmaceutical interventions on COVID-19 in 11 European countries
30 March 2020 Imperial College COVID-19 Response Team
Seth Flaxmani Swapnil Mishra*, Axel Gandy*, H JulietteT Unwin, Helen Coupland, Thomas A Mellan, Harrison
Zhu, Tresnia Berah, Jeffrey W Eato... | What is an alternative way to estimate the course of an epidemic? | false | 837 | {
"text": [
"back-calculate infections from\nobserved deaths"
],
"answer_start": [
9002
]
} |
2,683 | Estimating the number of infections and the impact of non-
pharmaceutical interventions on COVID-19 in 11 European countries
30 March 2020 Imperial College COVID-19 Response Team
Seth Flaxmani Swapnil Mishra*, Axel Gandy*, H JulietteT Unwin, Helen Coupland, Thomas A Mellan, Harrison
Zhu, Tresnia Berah, Jeffrey W Eato... | Why is it hard to know the true incidence of infections number? | false | 1,074 | {
"text": [
"underreporting as well as systematic and country-specific changes in testing"
],
"answer_start": [
28430
]
} |
1,687 | Interactome analysis of the lymphocytic choriomeningitis virus nucleoprotein in infected cells reveals ATPase Na(+)/K(+) transporting subunit Alpha 1 and prohibitin as host-cell factors involved in the life cycle of mammarenaviruses
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834214/
SHA: efbd0dfc426da5dd25ce29411d... | How are Mammarenaviruses spread from rodents to humans? | false | 5,149 | {
"text": [
"mucosal exposure to aerosols or by direct contact of abraded skin with infectious material"
],
"answer_start": [
2592
]
} |
1,602 | High Burden of Non-Influenza Viruses in Influenza-Like Illness in the Early Weeks of H1N1v Epidemic in France
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3157400/
SHA: f4c1afe385e9e31eb5678e15a3c280ba97326554
Authors: Schnepf, Nathalie; Resche-Rigon, Matthieu; Chaillon, Antoine; Scemla, Anne; Gras, Guillaume; Semou... | What network of physicians provides real-time clinical data on the spread of influenza in France? | false | 5,263 | {
"text": [
"Réseau Sentinelles"
],
"answer_start": [
2654
]
} |
650 | Role of S-Palmitoylation on IFITM5 for the Interaction with FKBP11 in Osteoblast Cells
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776769/
Tsukamoto, Takashi; Li, Xianglan; Morita, Hiromi; Minowa, Takashi; Aizawa, Tomoyasu; Hanagata, Nobutaka; Demura, Makoto
2013-09-18
DOI:10.1371/journal.pone.0075831
License:cc-by... | What regulates the antiviral activity of IFITM3? | false | 573 | {
"text": [
"S-palmitoylation on the protein"
],
"answer_start": [
3574
]
} |
1,719 | Virus-Vectored Influenza Virus Vaccines
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147686/
SHA: f6d2afb2ec44d8656972ea79f8a833143bbeb42b
Authors: Tripp, Ralph A.; Tompkins, S. Mark
Date: 2014-08-07
DOI: 10.3390/v6083055
License: cc-by
Abstract: Despite the availability of an inactivated vaccine that has been lic... | What did the clinical trial with VRP show? | false | 1,574 | {
"text": [
"vaccine was safe and despite high vector-specific immunity after initial immunization, continued to boost transgene-specific immune responses upon boost"
],
"answer_start": [
19091
]
} |
2,634 | Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067204/
SHA: c097a8a9a543d69c34f10e5c3fd78019e560026a
Authors: Chan, Jasper Fuk-Woo; Kok, Kin-Hang; Zhu, Zheng; Chu, Hin; To, Kelv... | What is the relation between the new2019-nCOV and the conserved orf8? | false | 3,735 | {
"text": [
"the new 2019-nCoV orf8 is distant from the conserved orf8"
],
"answer_start": [
12762
]
} |
1,645 | Pre-existing immunity against vaccine vectors – friend or foe?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3542731/
SHA: f5bdf18567bb3760e1ce05008135f0270badbd5c
Authors: Saxena, Manvendra; Van, Thi Thu Hao; Baird, Fiona J.; Coloe, Peter J.; Smooker, Peter M.
Date: 2013-01-27
DOI: 10.1099/mic.0.049601-0
License: cc... | What are important criteria for selecting vaccine delivery vectors? | false | 845 | {
"text": [
"long-lasting cellular and (where appropriate) humoral immune responses to the vectored antigen must be induced following administration of these vaccines, preferably with a single dose"
],
"answer_start": [
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]
} |
1,679 | Venezuelan Equine Encephalitis Virus Induces Apoptosis through the Unfolded Protein Response Activation of EGR1
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4794670/
SHA: f4aa788ab898b28b00ee103e4d4ab24a2c684caf
Authors: Baer, Alan; Lundberg, Lindsay; Swales, Danielle; Waybright, Nicole; Pinkham, Chelsea; Dinman, Jo... | What is EGR1? | false | 943 | {
"text": [
"a transcription factor"
],
"answer_start": [
33378
]
} |
2,643 | Responding to the COVID-19 pandemic in complex humanitarian crises
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7085188/
SHA: d013e42811c6442b184da3b9bbfd9e334031a975
Authors: Poole, Danielle N.; Escudero, Daniel J.; Gostin, Lawrence O.; Leblang, David; Talbot, Elizabeth A.
Date: 2020-03-21
DOI: 10.1186/s12939-020-0... | What resources need to be identified? | false | 1,920 | {
"text": [
"to protect healthcare workers, develop and deploy rapid testing, improve surveillance, and enact quarantine and isolation of contacts and cases."
],
"answer_start": [
3037
]
} |
1,686 | Nucleolar Protein Trafficking in Response to HIV-1 Tat: Rewiring the Nucleolus
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499507/
SHA: efa871aeaf22cbd0ce30e8bd1cb3d1afff2a98f9
Authors: Jarboui, Mohamed Ali; Bidoia, Carlo; Woods, Elena; Roe, Barbara; Wynne, Kieran; Elia, Giuliano; Hall, William W.; Gautier, Virgin... | How long is the nuclear protein PARP-1? | false | 5,141 | {
"text": [
"113 kDa"
],
"answer_start": [
10640
]
} |
2,683 | Estimating the number of infections and the impact of non-
pharmaceutical interventions on COVID-19 in 11 European countries
30 March 2020 Imperial College COVID-19 Response Team
Seth Flaxmani Swapnil Mishra*, Axel Gandy*, H JulietteT Unwin, Helen Coupland, Thomas A Mellan, Harrison
Zhu, Tresnia Berah, Jeffrey W Eato... | What is the population-averaged infection fatality ratio? | false | 1,086 | {
"text": [
"adjusted for the age structure and contact patterns of\neach country"
],
"answer_start": [
32785
]
} |
1,741 | MERS coronavirus: diagnostics, epidemiology and transmission
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687373/
SHA: f6fcf1a99cbd073c5821d1c4ffa3f2c6daf8ae29
Authors: Mackay, Ian M.; Arden, Katherine E.
Date: 2015-12-22
DOI: 10.1186/s12985-015-0439-5
License: cc-by
Abstract: The first known cases of Middle East ... | How was the first culture of the new Coronavirus announced? | false | 4,190 | {
"text": [
"An email from Dr Ali Mohamed Zaki, an Egyptian virologist working at the Dr Soliman Fakeeh Hospital in Jeddah in the Kingdom of Saudi Arabia (KSA)"
],
"answer_start": [
2831
]
} |
1,628 | Evidence for the Convergence Model: The Emergence of Highly Pathogenic Avian Influenza (H5N1) in Viet Nam
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4580613/
SHA: ee5b43d20a640664510cb7a540caaae4a8e19933
Authors: Saksena, Sumeet; Fox, Jefferson; Epprecht, Michael; Tran, Chinh C.; Nong, Duong H.; Spencer, James H.;... | What is the relationship between HIN1 viral transmission and poultry production. | false | 587 | {
"text": [
"landscapes where intensive and extensive forms of poultry production overlap were found at greater risk"
],
"answer_start": [
1877
]
} |
1,660 | Hantaviruses in the Americas and Their Role as Emerging Pathogens
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185593/
SHA: efe13a8d42b60ef9f7387ea539a1b2eeb5f80101
Authors: Hjelle, Brian; Torres-Pérez, Fernando
Date: 2010-11-25
DOI: 10.3390/v2122559
License: cc-by
Abstract: The continued emergence and re-emergenc... | What is N-protein? | false | 4,494 | {
"text": [
"a structural component of the viral nucleocapsid"
],
"answer_start": [
10217
]
} |
2,628 | Haunted with and hunting for viruses
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7089303/
SHA: c51c4f6146d0c636bc4dc3839c16b9e3ef52849a
Authors: Gao, George Fu; Wu, Ying
Date: 2013-08-07
DOI: 10.1007/s11427-013-4525-x
License: cc-by
Abstract: nan
Text: pecially with next-generation sequencing (NGS) for new virus ... | What assay played an important role? | false | 3,850 | {
"text": [
"reverse transcription polymerase chain reaction (RT-PCR)"
],
"answer_start": [
2606
]
} |
1,741 | MERS coronavirus: diagnostics, epidemiology and transmission
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687373/
SHA: f6fcf1a99cbd073c5821d1c4ffa3f2c6daf8ae29
Authors: Mackay, Ian M.; Arden, Katherine E.
Date: 2015-12-22
DOI: 10.1186/s12985-015-0439-5
License: cc-by
Abstract: The first known cases of Middle East ... | How has the vast majority of MERS-CoV transmission occurred? | false | 4,376 | {
"text": [
"from infected to uninfected humans in close and prolonged contact"
],
"answer_start": [
66077
]
} |
2,643 | Responding to the COVID-19 pandemic in complex humanitarian crises
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7085188/
SHA: d013e42811c6442b184da3b9bbfd9e334031a975
Authors: Poole, Danielle N.; Escudero, Daniel J.; Gostin, Lawrence O.; Leblang, David; Talbot, Elizabeth A.
Date: 2020-03-21
DOI: 10.1186/s12939-020-0... | What is essential when pandemics threaten vulnerable populations? | false | 1,933 | {
"text": [
"Transparent and credible information-sharing mechanisms"
],
"answer_start": [
5416
]
} |
2,683 | Estimating the number of infections and the impact of non-
pharmaceutical interventions on COVID-19 in 11 European countries
30 March 2020 Imperial College COVID-19 Response Team
Seth Flaxmani Swapnil Mishra*, Axel Gandy*, H JulietteT Unwin, Helen Coupland, Thomas A Mellan, Harrison
Zhu, Tresnia Berah, Jeffrey W Eato... | Which Western European country is estimated to have the lowest attack rate? | false | 844 | {
"text": [
"Germany"
],
"answer_start": [
12748
]
} |
1,578 | Inhibitory Effect and Possible Mechanism of Action of Patchouli Alcohol against Influenza A (H2N2) Virus
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264369/
SHA: f2d842780b9928cc70f38a4458553f2431877603
Authors: Wu, Huaxing; Li, Beili; Wang, Xue; Jin, Mingyuan; Wang, Guonian
Date: 2011-08-03
DOI: 10.3390/molecules... | What was the conclusion of this study? | false | 4,076 | {
"text": [
"patchouli alcohol possesses anti-influenza A (H2N2) virus activity"
],
"answer_start": [
18530
]
} |
2,668 | 2019-nCoV: The Identify-Isolate-Inform (3I) Tool Applied to a Novel Emerging Coronavirus
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081861/
SHA: f323af9a07cc54faf9bdbabadaacb0e8b46f99a2
Authors: Koenig, Kristi L.; Beÿ, Christian K.; McDonald, Eric C.
Date: 2020-01-31
DOI: 10.5811/westjem.2020.1.46760
License: cc-... | When was the second COVID19 case reported in the US? | false | 2,188 | {
"text": [
"January 24, 2020"
],
"answer_start": [
4723
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} |
1,629 | The Intranasal Application of Zanamivir and Carrageenan Is Synergistically Active against Influenza A Virus in the Murine Model
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459876/
SHA: f0b1fa4036434b57c8307d43c39a4193f7e8053a
Authors: Morokutti-Kurz, Martina; König-Schuster, Marielle; Koller, Christiane; Graf, Chr... | What percentage of people infected with influenza have a viral coinfection? | false | 2,153 | {
"text": [
"Analysis by qRT-PCR revealed that 54.5-83.3% of influenza A or B positive patients were found to have at least one concomitant respiratory viral infection [9] [10] [11] [12] . The detection frequency with immunofluorescence was found to be even higher (90-100%) [13, 14] ."
],
"answer_start": [
... |
1,629 | The Intranasal Application of Zanamivir and Carrageenan Is Synergistically Active against Influenza A Virus in the Murine Model
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459876/
SHA: f0b1fa4036434b57c8307d43c39a4193f7e8053a
Authors: Morokutti-Kurz, Martina; König-Schuster, Marielle; Koller, Christiane; Graf, Chr... | What is the recovery benefit of carageenan in patients with any respiratory virus? | false | 2,158 | {
"text": [
"1.9 day faster recovery from common cold symptoms than placebo treated patients in the intention-to-treat population"
],
"answer_start": [
6219
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} |
630 | Functional Genetic Variants in DC-SIGNR Are Associated with Mother-to-Child Transmission of HIV-1
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752805/
Boily-Larouche, Geneviève; Iscache, Anne-Laure; Zijenah, Lynn S.; Humphrey, Jean H.; Mouland, Andrew J.; Ward, Brian J.; Roger, Michel
2009-10-07
DOI:10.1371/journal.... | Why do low levels of DC-SIGNR enhance Mother to Child Transmission of HIV-1? | false | 307 | {
"text": [
"in placenta containing low levels of DC-SIGNR, HIV-1 would preferentially binds CCR5 on endothelial cells resulting in a loss of placental barrier integrity and enhanced passage of maternal HIV-1-infected cells in foetal circulation leading to MTCT of HIV-1"
],
"answer_start": [
29090
]
} |
2,669 | Frontiers in antiviral therapy and immunotherapy
https://doi.org/10.1002/cti2.1115
SHA: facbfdfa7189ca9ff83dc30e5d241ab22e962dbf
Authors: Heaton, Steven M
Date: 2020
DOI: 10.1002/cti2.1115
License: cc-by
Abstract: nan
Text: Globally, recent decades have witnessed a growing disjunction, a 'Valley of Death' 1,2 no l... | What do Australia's Medical Research and Innovation Priorities include? | false | 4,170 | {
"text": [
"antimicrobial resistance, global health and health security, drug repurposing and translational research infrastructure,"
],
"answer_start": [
9226
]
} |
1,606 | Serological Assays Based on Recombinant Viral Proteins for the Diagnosis of Arenavirus Hemorrhagic Fevers
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3497043/
SHA: f1d308db379b3c293bcfc8fe251c043fe8842358
Authors: Fukushi, Shuetsu; Tani, Hideki; Yoshikawa, Tomoki; Saijo, Masayuki; Morikawa, Shigeru
Date: 2012-10-12... | What diagnostic test has been show to have excellent sensitivity in detecting viral infections? | false | 5,276 | {
"text": [
"PCR assays"
],
"answer_start": [
16937
]
} |
641 | RNAi Therapeutic Platforms for Lung Diseases
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816685/
Fujita, Yu; Takeshita, Fumitaka; Kuwano, Kazuyoshi; Ochiya, Takahiro
2013-02-06
DOI:10.3390/ph6020223
License:cc-by
Abstract: RNA interference (RNAi) is rapidly becoming an important method for analyzing gene functions... | What are the essential conditions in siRNA delivery to effectively produce gene silencing in the lungs? | false | 1,621 | {
"text": [
"delivered to their site of action, be stable, enter the target cells, and be present in the cytoplasm at sufficient concentration"
],
"answer_start": [
10025
]
} |
1,660 | Hantaviruses in the Americas and Their Role as Emerging Pathogens
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185593/
SHA: efe13a8d42b60ef9f7387ea539a1b2eeb5f80101
Authors: Hjelle, Brian; Torres-Pérez, Fernando
Date: 2010-11-25
DOI: 10.3390/v2122559
License: cc-by
Abstract: The continued emergence and re-emergenc... | When does the cleavage appear to be signaled? | false | 4,471 | {
"text": [
"after the conserved peptide signal WAASA at the C-terminal of Gn"
],
"answer_start": [
5471
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} |
2,634 | Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067204/
SHA: c097a8a9a543d69c34f10e5c3fd78019e560026a
Authors: Chan, Jasper Fuk-Woo; Kok, Kin-Hang; Zhu, Zheng; Chu, Hin; To, Kelv... | What COVs were known to infect humans before December 2019? | false | 3,702 | {
"text": [
"6 CoVs were known to infect human, including 2 αCoV (HCoV-229E and HKU-NL63) and 4 βCoV (HCoV-OC43 ["
],
"answer_start": [
3165
]
} |
1,660 | Hantaviruses in the Americas and Their Role as Emerging Pathogens
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185593/
SHA: efe13a8d42b60ef9f7387ea539a1b2eeb5f80101
Authors: Hjelle, Brian; Torres-Pérez, Fernando
Date: 2010-11-25
DOI: 10.3390/v2122559
License: cc-by
Abstract: The continued emergence and re-emergenc... | What leads to death in most fatal cases of HCPS? | false | 4,557 | {
"text": [
"intoxication of the heart by as-yet-undefined mediators that leads to the low cardiac output state and the associated shock syndrome"
],
"answer_start": [
17586
]
} |
1,719 | Virus-Vectored Influenza Virus Vaccines
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147686/
SHA: f6d2afb2ec44d8656972ea79f8a833143bbeb42b
Authors: Tripp, Ralph A.; Tompkins, S. Mark
Date: 2014-08-07
DOI: 10.3390/v6083055
License: cc-by
Abstract: Despite the availability of an inactivated vaccine that has been lic... | How did the VEE based replicon system incorporating HA from PR8perform? | false | 1,569 | {
"text": [
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1,566 | Aetiology of Acute Respiratory Tract Infections in Hospitalised Children in Cyprus
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2,683 | Estimating the number of infections and the impact of non-
pharmaceutical interventions on COVID-19 in 11 European countries
30 March 2020 Imperial College COVID-19 Response Team
Seth Flaxmani Swapnil Mishra*, Axel Gandy*, H JulietteT Unwin, Helen Coupland, Thomas A Mellan, Harrison
Zhu, Tresnia Berah, Jeffrey W Eato... | What are examples of social distancing? | false | 811 | {
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2,526 | Epidemiological research priorities for public health control of the ongoing global novel coronavirus (2019-nCoV) outbreak
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Authors: Cowling, Benjamin J; Leung, Gabriel M
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2,620 | Estimating the Unreported Number of Novel Coronavirus (2019-nCoV) Cases in China in the First Half of January 2020: A Data-Driven Modelling Analysis of the Early Outbreak
https://doi.org/10.3390/jcm9020388
SHA: bf20dda99538a594eafc258553634fd9195104cb
Authors: Zhao, Shi; Musa, Salihu S.; Lin, Qianying; Ran, Jinjun; ... | What was the result of under-reporting? | false | 1,875 | {
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186 | Identifying Locations with Possible Undetected Imported Severe Acute Respiratory Syndrome Coronavirus 2 Cases by Using Importation Predictions,
https://wwwnc.cdc.gov/eid/article/26/7/20-0250_article
Volume 26, Number 7—July 2020
Research
Pablo Martinez De Salazar1Comments to Author , René Niehus, Aimee Taylor1, Caroli... | What factor positively correlates with imported-and-reported cases counts of SARS-CoV-2 infection? | false | 247 | {
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2,504 | Respiratory Viral Infections in Exacerbation of Chronic Airway Inflammatory Diseases: Novel Mechanisms and Insights From the Upper Airway Epithelium
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Authors: Tan, Kai Sen; Lim, Rachel Liyu; Liu, Jing; Ong, Hsiao Hui; ... | What happens in the case of COPD? | false | 3,952 | {
"text": [
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1,698 | Accelerated viral dynamics in bat cell lines, with implications for zoonotic emergence
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7064339/
SHA: f2cc0d63ff2c4aaa127c4caae21d8f3a0067e3d5
Authors: Brook, Cara E; Boots, Mike; Chandran, Kartik; Dobson, Andrew P; Drosten, Christian; Graham, Andrea L; Grenfell, Bryan T; ... | What was the finding in this study? | false | 2,742 | {
"text": [
"that bat cell lines demonstrated a signature of enhanced interferon-mediated immune response, of either constitutive or induced form, which allowed for establishment of rapid within-host, cell-to-cell virus transmission rates"
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1,671 | Host resilience to emerging coronaviruses
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7079962/
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Authors: Jamieson, Amanda M
Date: 2016-07-01
DOI: 10.2217/fvl-2016-0060
License: cc-by
Abstract: Recently, two coronaviruses, severe acute respiratory syndrome coronavirus an... | What is the role of statins in increasing host resilience to viral lung infections? | false | 1,278 | {
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1,690 | Viruses and Evolution – Viruses First? A Personal Perspective
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433886/
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Authors: Moelling, Karin; Broecker, Felix
Date: 2019-03-19
DOI: 10.3389/fmicb.2019.00523
License: cc-by
Abstract: The discovery of exoplanets within putat... | Which are the most abundant biological entities on Earth? | false | 1,175 | {
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1,741 | MERS coronavirus: diagnostics, epidemiology and transmission
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687373/
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Authors: Mackay, Ian M.; Arden, Katherine E.
Date: 2015-12-22
DOI: 10.1186/s12985-015-0439-5
License: cc-by
Abstract: The first known cases of Middle East ... | When did the first known cases of Middle East respiratory syndrome (MERS) occur? | false | 4,173 | {
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2,684 | 1918 Influenza: the Mother of All Pandemics
Jeffery K. Taubenberger" and David M. Morens1-
The “Spanish" influenza pandemic of 1918—1919,
which caused :50 million deaths worldwide, remains an
ominous warning to public health. Many questions about its
origins, its unusual epidemiologic features, and the basis of
its p... | Do seasonal temperatures and humidity explain the appearance of the three waves of the 1918 swine flu? | false | 1,101 | {
"text": [
"such factors cannot explain the 3 pandemic\nwaves of 1918-1919, which occurred in the spring-sum-\nmer, summer—fall, and winter (of the Northern\nHemisphere), respectively. The first 2 waves occurred at a\ntime of year normally unfavorable to influenza Virus\nspread. The second wave caused simultaneous... |
1,698 | Accelerated viral dynamics in bat cell lines, with implications for zoonotic emergence
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7064339/
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Authors: Brook, Cara E; Boots, Mike; Chandran, Kartik; Dobson, Andrew P; Drosten, Christian; Graham, Andrea L; Grenfell, Bryan T; ... | Why may the bats have this unique adaptation? | false | 2,727 | {
"text": [
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1,553 | Development of an ELISA-array for simultaneous detection of five encephalitis viruses
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3305475/
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"text": [
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1,591 | Whole genome sequencing and phylogenetic analysis of human metapneumovirus strains from Kenya and Zambia
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941262/
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Authors: Kamau, Everlyn; Oketch, John W.; de Laurent, Zaydah R.; Phan, My V. T.; Agoti, Charles N.; Nokes, D. Ja... | How many open reading frames are in the HMPV genome? | false | 4,064 | {
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2,668 | 2019-nCoV: The Identify-Isolate-Inform (3I) Tool Applied to a Novel Emerging Coronavirus
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081861/
SHA: f323af9a07cc54faf9bdbabadaacb0e8b46f99a2
Authors: Koenig, Kristi L.; Beÿ, Christian K.; McDonald, Eric C.
Date: 2020-01-31
DOI: 10.5811/westjem.2020.1.46760
License: cc-... | What symptoms might people experience with COVID19? | false | 2,194 | {
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1,741 | MERS coronavirus: diagnostics, epidemiology and transmission
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687373/
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Authors: Mackay, Ian M.; Arden, Katherine E.
Date: 2015-12-22
DOI: 10.1186/s12985-015-0439-5
License: cc-by
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"text": [
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1,603 | Genome Sequences of Porcine Epidemic Diarrhea Virus: In Vivo and In Vitro Phenotypes
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4056290/
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Authors: Lawrence, Paulraj K.; Bumgardner, Eric; Bey, Russell F.; Stine, Douglas; Bumgarner, Roger E.
Date: 2014-06-12
DOI: 10.1128/... | How does PEDV cause illness? | false | 5,267 | {
"text": [
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2,592 | A mathematical model for simulating the phase-based transmissibility of a novel coronavirus
https://doi.org/10.1186/s40249-020-00640-3
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Authors: Yin, Tian-Mu Chen; Jia, Rui; Qiu-Peng, Wang; Ze-Yu, Zhao; Jing-An, Cui; Ling
Date: 2020
DOI: 10.1186/s40249-020-00640-3
License... | What compartments were the host animals divided into? | false | 2,761 | {
"text": [
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1,689 | Chikungunya: A Potentially Emerging Epidemic?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2860491/
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Authors: Thiboutot, Michelle M.; Kannan, Senthil; Kawalekar, Omkar U.; Shedlock, Devon J.; Khan, Amir S.; Sarangan, Gopalsamy; Srikanth, Padma; Weiner, David B.; Muthumani... | What is te chronic stage characterized by? | false | 2,500 | {
"text": [
"by polyarthralgia that can last from weeks to years beyond the acute stage"
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188 | The Battle Against Coronavirus Disease 2019 (COVID-19): Emergency Management
and Infection Control in a Radiology Department
https://www.jacr.org/article/S1546-1440(20)30285-4/pdf
Journal Pre-proof
Zixing Huang, Shuang Zhao, Zhenlin Li, Weixia Chen, Lihong Zhao, Lipeng Deng, Bin
Song
PII: S1546-1440(20)30285-4
DOI: htt... | What must the data gathering include? | false | 2,458 | {
"text": [
"up-to-date case definitions and information about\nconfirmatory tests to all staff with direct patient contact to allow appropriate barrier precautions\nto be taken."
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1,561 | Acute Hemorrhagic Encephalitis Responding to Combined Decompressive Craniectomy, Intravenous Immunoglobulin, and Corticosteroid Therapies: Association with Novel RANBP2 Variant
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5857578/
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1,625 | Rotavirus A in wild and domestic animals from areas with environmental degradation in the Brazilian Amazon
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298726/
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Authors: de Barros, Bruno de Cássio Veloso; Chagas, Elaine Nunes; Bezerra, Luna Wanessa; Ribeiro, Laila Grazie... | Is Rotavirus single or double-stranded? | false | 431 | {
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2,684 | 1918 Influenza: the Mother of All Pandemics
Jeffery K. Taubenberger" and David M. Morens1-
The “Spanish" influenza pandemic of 1918—1919,
which caused :50 million deaths worldwide, remains an
ominous warning to public health. Many questions about its
origins, its unusual epidemiologic features, and the basis of
its p... | Are the modern day Influenza viruses related to the 1918 Spanish Influenza virus? | false | 1,062 | {
"text": [
"All influenza A pandemics since that time, and\nindeed almost all cases of influenza A worldwide (except-\ning human infections from avian Viruses such as H5N1 and\nH7N7), have been caused by descendants of the 1918\nVirus, including “drifted” H1N1 Viruses and reassorted\nH2N2 and H3N2 Viruses."
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1,645 | Pre-existing immunity against vaccine vectors – friend or foe?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3542731/
SHA: f5bdf18567bb3760e1ce05008135f0270badbd5c
Authors: Saxena, Manvendra; Van, Thi Thu Hao; Baird, Fiona J.; Coloe, Peter J.; Smooker, Peter M.
Date: 2013-01-27
DOI: 10.1099/mic.0.049601-0
License: cc... | What are methods to avoid the effect of vector immune response on the efficacy of vaccination? | false | 878 | {
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"The inhibitory effect of pre-existing immunity can also be avoided by masking the Ad vector inside dendritic cells (DCs) (Steffensen et al., 2012) . In addition, mucosal vaccination or administration of higher vaccine doses can overcome pre-existing immunity problems (Alexander et al., 2012; Belyakov... |
1,620 | A missense mutation in Katnal1 underlies behavioural, neurological and ciliary anomalies
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5761721/
SHA: f4cebabd74b16e710fb41a737d8ef84b7d565d8d
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"text": [
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1,595 | Severe Acute Respiratory Syndrome Coronavirus Viroporin 3a Activates the NLRP3 Inflammasome
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361828/
SHA: f02d0c1e8b0109648e578662dc250abe349a033c
Authors: Chen, I-Yin; Moriyama, Miyu; Chang, Ming-Fu; Ichinohe, Takeshi
Date: 2019-01-29
DOI: 10.3389/fmicb.2019.00050
Licens... | How does NLRP3 detect RNA viral infection? | false | 292 | {
"text": [
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1,698 | Accelerated viral dynamics in bat cell lines, with implications for zoonotic emergence
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7064339/
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Authors: Brook, Cara E; Boots, Mike; Chandran, Kartik; Dobson, Andrew P; Drosten, Christian; Graham, Andrea L; Grenfell, Bryan T; ... | What is presented in this study? | false | 2,752 | {
"text": [
"general methods to study cross-scale viral dynamics, which suggest that within-host persistence is supported by robust antiviral responses characteristic of bat immune processes."
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} |
2,684 | 1918 Influenza: the Mother of All Pandemics
Jeffery K. Taubenberger" and David M. Morens1-
The “Spanish" influenza pandemic of 1918—1919,
which caused :50 million deaths worldwide, remains an
ominous warning to public health. Many questions about its
origins, its unusual epidemiologic features, and the basis of
its p... | What was the death toll in the 1918-1919 Spanish Influenza epidemic? | false | 1,057 | {
"text": [
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1,583 | A super-spreading ewe infects hundreds with Q fever at a farmers' market in Germany
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1618839/
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Authors: Porten, Klaudia; Rissland, Jürgen; Tigges, Almira; Broll, Susanne; Hopp, Wilfried; Lunemann, Mechthild; van Treeck, Ulrich; ... | What was the interquartile range of the incubation period? | false | 5,204 | {
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2,461 | Mucosal immune responses induced by oral administration recombinant Bacillus subtilis expressing the COE antigen of PEDV in newborn piglets
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418403/
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Authors: Wang, Jialu; Huang, Lulu; Mou, Chunxiao; Zhang, En; Wang, Yongheng; ... | What type of cells form the intestinal mucosal barrier? | false | 610 | {
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1,595 | Severe Acute Respiratory Syndrome Coronavirus Viroporin 3a Activates the NLRP3 Inflammasome
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361828/
SHA: f02d0c1e8b0109648e578662dc250abe349a033c
Authors: Chen, I-Yin; Moriyama, Miyu; Chang, Ming-Fu; Ichinohe, Takeshi
Date: 2019-01-29
DOI: 10.3389/fmicb.2019.00050
Licens... | What is the genus of the SARS coronavirus? | false | 283 | {
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1,663 | Effectiveness of zinc supplementation on diarrhea and average daily gain in pre-weaned dairy calves: A double-blind, block-randomized, placebo-controlled clinical trial
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6619766/
SHA: ef20a0cd67ce018cf061f154bd8be9d0e58d0f23
Authors: Feldmann, Hillary R.; Williams, Deniece... | What preventative measure has been taken to decrease the incidence of diarrhea in children? | false | 5,174 | {
"text": [
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2,620 | Estimating the Unreported Number of Novel Coronavirus (2019-nCoV) Cases in China in the First Half of January 2020: A Data-Driven Modelling Analysis of the Early Outbreak
https://doi.org/10.3390/jcm9020388
SHA: bf20dda99538a594eafc258553634fd9195104cb
Authors: Zhao, Shi; Musa, Salihu S.; Lin, Qianying; Ran, Jinjun; ... | Who release the time series data from 10th to 20th January 2020? | false | 1,893 | {
"text": [
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2,437 | Screening of FDA-Approved Drugs for Inhibitors of Japanese Encephalitis Virus Infection
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5640845/
SHA: 1bd2f6497996fc0fccd8dffd7f84846d3d36f964
Authors: Wang, Shaobo; Liu, Yang; Guo, Jiao; Wang, Peilin; Zhang, Leike; Xiao, Gengfu; Wang, Wei
Date: 2017-10-13
DOI: 10.1128/jv... | What is the mechanism of action for manidipine? | false | 1,224 | {
"text": [
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"answer_start": [
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2,527 | On the Coronavirus (COVID-19) Outbreak and the Smart City Network: Universal Data Sharing Standards Coupled with Artificial Intelligence (AI) to Benefit Urban Health Monitoring and Management
https://doi.org/10.3390/healthcare8010046
SHA: 90d04764b497a224a1d969f4e317fc19a5feab35
Authors: Allam, Zaheer; Jones, David ... | What platform was instrumental in rapid sharing of COVID-19 information? | false | 1,240 | {
"text": [
"Global Initiative on Sharing All Influenza Data (GISAID)"
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"answer_start": [
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2,486 | Potential Rapid Diagnostics, Vaccine and Therapeutics for 2019 Novel Coronavirus (2019-nCoV): A Systematic Review
https://doi.org/10.3390/jcm9030623
SHA: 9b0c87f808b1b66f2937d7a7acb524a756b6113b
Authors: Pang, Junxiong; Wang, Min Xian; Ang, Ian Yi Han; Tan, Sharon Hui Xuan; Lewis, Ruth Frances; Chen, Jacinta I. Pei;... | Who are the majority of cases? | false | 3,620 | {
"text": [
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2,486 | Potential Rapid Diagnostics, Vaccine and Therapeutics for 2019 Novel Coronavirus (2019-nCoV): A Systematic Review
https://doi.org/10.3390/jcm9030623
SHA: 9b0c87f808b1b66f2937d7a7acb524a756b6113b
Authors: Pang, Junxiong; Wang, Min Xian; Ang, Ian Yi Han; Tan, Sharon Hui Xuan; Lewis, Ruth Frances; Chen, Jacinta I. Pei;... | What are key limtations of genetic detection? | false | 3,661 | {
"text": [
"lack of knowledge of the presence of viable virus, the potential cross-reactivity with non-specific genetic regions and the short timeframe for accurate detection during the acute infection phase."
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1,698 | Accelerated viral dynamics in bat cell lines, with implications for zoonotic emergence
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7064339/
SHA: f2cc0d63ff2c4aaa127c4caae21d8f3a0067e3d5
Authors: Brook, Cara E; Boots, Mike; Chandran, Kartik; Dobson, Andrew P; Drosten, Christian; Graham, Andrea L; Grenfell, Bryan T; ... | What difference bats demonstrate compared to most non-Chiropteran mammals? | false | 2,722 | {
"text": [
"no obvious disease symptoms upon infection with pathogens that are highly virulent in non-volant mammals (Schountz et al., 2017) but may, instead, support viruses as longterm persistent infections, rather than transient, immunizing pathologies"
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1,656 | Improved Pharmacological and Structural Properties of HIV Fusion Inhibitor AP3 over Enfuvirtide: Highlighting Advantages of Artificial Peptide Strategy
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4541410/
SHA: f2fcc16391f946c99717b63ec9a24e5384aac381
Authors: Zhu, Xiaojie; Zhu, Yun; Ye, Sheng; Wang, Qian; Xu, Wei; ... | What do the results suggest? | false | 2,257 | {
"text": [
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1,686 | Nucleolar Protein Trafficking in Response to HIV-1 Tat: Rewiring the Nucleolus
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499507/
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Authors: Jarboui, Mohamed Ali; Bidoia, Carlo; Woods, Elena; Roe, Barbara; Wynne, Kieran; Elia, Giuliano; Hall, William W.; Gautier, Virgin... | How many proteins were shown to change the amount of Jurkat T-cell nucleolus significantly? | false | 5,132 | {
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2,634 | Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067204/
SHA: c097a8a9a543d69c34f10e5c3fd78019e560026a
Authors: Chan, Jasper Fuk-Woo; Kok, Kin-Hang; Zhu, Zheng; Chu, Hin; To, Kelv... | What do the results indicate? | false | 3,730 | {
"text": [
"that different orf3b proteins display different IFN antagonist activities and this function is independent of the protein's nuclear localization, suggesting a potential link between bat SARS-related-CoV orf3b function and pathogenesis."
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2,463 | SARS to novel coronavirus – old lessons and new lessons
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026896/
SHA: 5d254ed178c092d3639ce70ae9653593acc471f9
Authors: McCloskey, Brian; Heymann, David L.
Date: 2020-02-05
DOI: 10.1017/s0950268820000254
License: cc-by
Abstract: The response to the novel coronavirus outb... | How long did it take to publish the full genomic sequence of SARS-CoV-2 after it was identified? | false | 1,210 | {
"text": [
"2 weeks"
],
"answer_start": [
5951
]
} |
2,461 | Mucosal immune responses induced by oral administration recombinant Bacillus subtilis expressing the COE antigen of PEDV in newborn piglets
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418403/
SHA: 5caced13bcb8a42cca41369c5a71ae7df5381ca8
Authors: Wang, Jialu; Huang, Lulu; Mou, Chunxiao; Zhang, En; Wang, Yongheng; ... | What is the role of dendritic cells in the immune response? | false | 607 | {
"text": [
"antigen-presenting cells"
],
"answer_start": [
4887
]
} |
1,572 | iNR-Drug: Predicting the Interaction of Drugs with Nuclear Receptors in Cellular Networking
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3975431/
SHA: ee55aea26f816403476a7cb71816b8ecb1110329
Authors: Fan, Yue-Nong; Xiao, Xuan; Min, Jian-Liang; Chou, Kuo-Chen
Date: 2014-03-19
DOI: 10.3390/ijms15034915
License: cc-by... | What are the shortcomings of X-ray crystallography? | false | 3,264 | {
"text": [
"time-consuming and expensive"
],
"answer_start": [
3293
]
} |
2,504 | Respiratory Viral Infections in Exacerbation of Chronic Airway Inflammatory Diseases: Novel Mechanisms and Insights From the Upper Airway Epithelium
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7052386/
SHA: 45a566c71056ba4faab425b4f7e9edee6320e4a4
Authors: Tan, Kai Sen; Lim, Rachel Liyu; Liu, Jing; Ong, Hsiao Hui; ... | What is another area of interest? | false | 3,991 | {
"text": [
"the relationship between asthma and COPD exacerbations and their association with the airway microbiome."
],
"answer_start": [
23156
]
} |
1,604 | Emergent severe acute respiratory distress syndrome caused by adenovirus type 55 in immunocompetent adults in 2013: a prospective observational study
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4243941/
SHA: f5b706d0529bfcf7e2d1dfc037df5b6f95fc5ec0
Authors: Sun, Bing; He, Hangyong; Wang, Zheng; Qu, Jiuxin; Li, Xuya... | What is the mortality rate of severe ARDS from human adenovirus type 55 (HAdV-55)? | false | 3,255 | {
"text": [
"HAdV-55-induced severe ARDS has a very high mortality rate (80%) despite appropriate respiratory support."
],
"answer_start": [
13514
]
} |
1,662 | The Evolutionary Dynamics of the Lion Panthera leo Revealed by Host and Viral Population Genomics
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2572142/
SHA: f2af8027b6801850481d09ad0d4c5eb8e31c7d7f
Authors: Antunes, Agostinho; Troyer, Jennifer L.; Roelke, Melody E.; Pecon-Slattery, Jill; Packer, Craig; Winterbach, C... | When did lions first occupy Europe? | false | 5,171 | {
"text": [
"By Mid Pleistocene (,500,000 years ago)"
],
"answer_start": [
2506
]
} |
2,504 | Respiratory Viral Infections in Exacerbation of Chronic Airway Inflammatory Diseases: Novel Mechanisms and Insights From the Upper Airway Epithelium
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7052386/
SHA: 45a566c71056ba4faab425b4f7e9edee6320e4a4
Authors: Tan, Kai Sen; Lim, Rachel Liyu; Liu, Jing; Ong, Hsiao Hui; ... | Why should future studies be performed using metagenomics in addition to PCR analysis ? | false | 3,968 | {
"text": [
"to determine the contribution of the microbiome and mycobiome to viral infections."
],
"answer_start": [
16507
]
} |
1,660 | Hantaviruses in the Americas and Their Role as Emerging Pathogens
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185593/
SHA: efe13a8d42b60ef9f7387ea539a1b2eeb5f80101
Authors: Hjelle, Brian; Torres-Pérez, Fernando
Date: 2010-11-25
DOI: 10.3390/v2122559
License: cc-by
Abstract: The continued emergence and re-emergenc... | What do diminished pulse pressures, tachycardia, and hypotension in ANDV infected hamsters appear to closely mimic? | false | 4,568 | {
"text": [
"the shock that is believed to be the proximate cause of demise in patients who succumb to HCPS"
],
"answer_start": [
21133
]
} |
2,437 | Screening of FDA-Approved Drugs for Inhibitors of Japanese Encephalitis Virus Infection
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5640845/
SHA: 1bd2f6497996fc0fccd8dffd7f84846d3d36f964
Authors: Wang, Shaobo; Liu, Yang; Guo, Jiao; Wang, Peilin; Zhang, Leike; Xiao, Gengfu; Wang, Wei
Date: 2017-10-13
DOI: 10.1128/jv... | Where is Q130 located in the NS4B protein? | false | 1,223 | {
"text": [
"transmembrane domain 3"
],
"answer_start": [
1250
]
} |
187 | Preparation for Possible Sustained Transmission of 2019 Novel Coronavirus
Lessons From Previous Epidemics
https://jamanetwork.com/journals/jama/fullarticle/2761285
February 11, 2020
David L. Swerdlow, MD1; Lyn Finelli, DrPH, MS2
Author Affiliations Article Information
JAMA. 2020;323(12):1129-1130. doi:10.1001/jama.2020... | How many ventilators have past studies projected will be required for a pandemic in the United States? | false | 1,657 | {
"text": [
"35 000 to 60 000"
],
"answer_start": [
6331
]
} |
2,642 | First cases of coronavirus disease 2019 (COVID-19) in the WHO European Region, 24 January to 21 February 2020
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7068164/
SHA: ce358c18aac69fc83c7b2e9a7dca4a43b0f60e2e
Authors: Spiteri, Gianfranco; Fielding, James; Diercke, Michaela; Campese, Christine; Enouf, Vincent; Gayma... | What symptoms were reported? | false | 3,820 | {
"text": [
"Of the remaining 29, 20 reported fever, 14 reported cough and eight reported weakness. Additional symptoms reported included headaches (6 cases), sore throat (2), rhinorrhoea (2), shortness of breath (2), myalgia (1), diarrhoea (1) and nausea (1)"
],
"answer_start": [
7275
]
} |
1,656 | Improved Pharmacological and Structural Properties of HIV Fusion Inhibitor AP3 over Enfuvirtide: Highlighting Advantages of Artificial Peptide Strategy
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4541410/
SHA: f2fcc16391f946c99717b63ec9a24e5384aac381
Authors: Zhu, Xiaojie; Zhu, Yun; Ye, Sheng; Wang, Qian; Xu, Wei; ... | What is the serum half-life of T20? | false | 2,260 | {
"text": [
"about 2 h"
],
"answer_start": [
7917
]
} |
2,463 | SARS to novel coronavirus – old lessons and new lessons
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026896/
SHA: 5d254ed178c092d3639ce70ae9653593acc471f9
Authors: McCloskey, Brian; Heymann, David L.
Date: 2020-02-05
DOI: 10.1017/s0950268820000254
License: cc-by
Abstract: The response to the novel coronavirus outb... | Where did SARS-CoV-2 originate? | false | 1,199 | {
"text": [
"Wuhan City, China"
],
"answer_start": [
981
]
} |
2,669 | Frontiers in antiviral therapy and immunotherapy
https://doi.org/10.1002/cti2.1115
SHA: facbfdfa7189ca9ff83dc30e5d241ab22e962dbf
Authors: Heaton, Steven M
Date: 2020
DOI: 10.1002/cti2.1115
License: cc-by
Abstract: nan
Text: Globally, recent decades have witnessed a growing disjunction, a 'Valley of Death' 1,2 no l... | What is included in RBPs? | false | 4,141 | {
"text": [
"tristetraprolin and AUF1"
],
"answer_start": [
4182
]
} |
1,689 | Chikungunya: A Potentially Emerging Epidemic?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2860491/
SHA: f7c3160bef4169d29e2a8bdd79dd6e9056d4774c
Authors: Thiboutot, Michelle M.; Kannan, Senthil; Kawalekar, Omkar U.; Shedlock, Devon J.; Khan, Amir S.; Sarangan, Gopalsamy; Srikanth, Padma; Weiner, David B.; Muthumani... | What does Chikungunya mean in Swahili? | false | 2,480 | {
"text": [
"the illness of the bended walker"
],
"answer_start": [
1921
]
} |
1,571 | Community-acquired pneumonia in children — a changing spectrum of disease
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608782/
SHA: eecb946b106a94f26a79a964f0160e8e16f79f42
Authors: le Roux, David M.; Zar, Heather J.
Date: 2017-09-21
DOI: 10.1007/s00247-017-3827-8
License: cc-by
Abstract: Pneumonia remains the lea... | Case Fatality Rates for Childhood Pneumonia in high income vs low and middle income countries. | false | 515 | {
"text": [
"the case fatality rate is estimated to be almost 10-fold higher in low-and middle-income countries as compared to high-income countries"
],
"answer_start": [
3872
]
} |
1,595 | Severe Acute Respiratory Syndrome Coronavirus Viroporin 3a Activates the NLRP3 Inflammasome
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361828/
SHA: f02d0c1e8b0109648e578662dc250abe349a033c
Authors: Chen, I-Yin; Moriyama, Miyu; Chang, Ming-Fu; Ichinohe, Takeshi
Date: 2019-01-29
DOI: 10.3389/fmicb.2019.00050
Licens... | How many amino acids are in the SARS-CoV E protein? | false | 293 | {
"text": [
"76 amino acids"
],
"answer_start": [
5672
]
} |
2,634 | Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067204/
SHA: c097a8a9a543d69c34f10e5c3fd78019e560026a
Authors: Chan, Jasper Fuk-Woo; Kok, Kin-Hang; Zhu, Zheng; Chu, Hin; To, Kelv... | What is the RNA of the 2019-nCOV? | false | 3,713 | {
"text": [
"29891 nucleotides in size, encoding 9860 amino acids"
],
"answer_start": [
7519
]
} |
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