input stringlengths 2 974 | output dict | schema listlengths 0 0 |
|---|---|---|
Therefore, it would be advantageous to identify such persons and treat them preferentially. | {
"entities": {}
} | [] |
On the basis of these unique properties, the newly characterized hemagglutinin has been termed Limulus 18K agglutination-aggregation factor (18K-LAF). | {
"entities": {
"gene": [
{
"text": "hemagglutinin",
"start": 65,
"end": 78
},
{
"text": "Limulus 18K agglutination-aggregation factor",
"start": 95,
"end": 139
},
{
"text": "18K-LAF",
"start": 141,
"end": 148
... | [] |
The shift to the nonpermissive temperature is accompanied by the loss of guanyl nucleotide-dependent activity of adenylylcyclase in vitro. | {
"entities": {
"gene": [
{
"text": "adenylylcyclase",
"start": 113,
"end": 128
}
]
}
} | [] |
Clin. | {
"entities": {}
} | [] |
The data indicate that the minimal catalytic domain of Nmt1p is located between Ile59--> Phe96 and Gly451--> Leu455. | {
"entities": {
"gene": [
{
"text": "Nmt1p",
"start": 55,
"end": 60
}
]
}
} | [] |
It corresponds to the complete mitochondrial presequence and the lipoyl-bearing domain that are encoded by exons I through IV of the functional E2 gene. | {
"entities": {
"gene": [
{
"text": "E2 gene",
"start": 144,
"end": 151
}
]
}
} | [] |
Human neutrophil response to short-term exposure to F-75 cobalt-based alloy. | {
"entities": {}
} | [] |
Disruption of microtubules did not affect the fidelity or kinetics of vacuolar protein sorting, indicating that Vps1p function is not dependent on microtubules. | {
"entities": {
"gene": [
{
"text": "Vps1p",
"start": 112,
"end": 117
}
]
}
} | [] |
A mutant form of Vps1p lacking the entire GTP-binding domain interfered with vacuolar protein sorting in wild-type cells. | {
"entities": {
"gene": [
{
"text": "Vps1p",
"start": 17,
"end": 22
}
]
}
} | [] |
According to out field research, the tick fauna was very rich throughout that area, and it was permissible enough to determine ticks as the vectors, based on arising of anti-SF group rickettsiae (SFGR) antibody in mice inoculated with some tick emulsions, findings of rickettsiae reactive to patient sera or a species-sp... | {
"entities": {
"gene": [
{
"text": "anti-SF group rickettsiae",
"start": 169,
"end": 194
},
{
"text": "SFGR",
"start": 196,
"end": 200
},
{
"text": "JSFR",
"start": 350,
"end": 354
},
{
"text... | [] |
Nucleotide sequence and transcriptional analysis of the polyhedrin gene of Spodoptera exigua nuclear polyhedrosis virus. | {
"entities": {
"gene": [
{
"text": "polyhedrin gene",
"start": 56,
"end": 71
}
]
}
} | [] |
Validation of automated systems--system definition. | {
"entities": {}
} | [] |
As a consequence of dark rearing, the numerical density of cortical neurons in area 17 amounted to about double of the value observed in normally reared kittens and was also significantly higher in area 18. | {
"entities": {}
} | [] |
These results suggest that decreased class I enhancer activity in Ad12-transformed cells may, at least in part, be due to the higher levels of an enhancer-specific factor, possibly acting as a repressor. | {
"entities": {}
} | [] |
A second domain, located in the C-terminal 437 amino acids of IE1, is required for inhibitory and DNA-binding activities. | {
"entities": {
"gene": [
{
"text": "IE1",
"start": 62,
"end": 65
}
]
}
} | [] |
In order to investigate the blood compatibility of autogenous vein graft (AVG), changes in prostacyclin (PGI2) production following harvesting and arterial implantation were studied experimentally. | {
"entities": {}
} | [] |
Subcutaneous administration of the somatostatin analogue, octreotide, 100 micrograms thrice daily, resulted in a sustained improvement in diarrhoea and disappearance of faecal incontinence without reducing calcitonin levels. | {
"entities": {
"gene": [
{
"text": "somatostatin",
"start": 35,
"end": 47
},
{
"text": "calcitonin",
"start": 206,
"end": 216
}
]
}
} | [] |
205, 285-290] and was subsequently cloned and sequenced [J. | {
"entities": {}
} | [] |
Nonreplicating vaccinia vector efficiently expresses recombinant genes. | {
"entities": {}
} | [] |
Interferon type I in protective body reactions in an experimental Klebsiella infection | {
"entities": {
"gene": [
{
"text": "Interferon type I",
"start": 0,
"end": 17
}
]
}
} | [] |
No other changes in hematopoietic differentiation status were observed in association with Id-SCL expression. | {
"entities": {
"gene": [
{
"text": "Id-SCL",
"start": 91,
"end": 97
}
]
}
} | [] |
For pressure greater than 121 atm abs, an increased excitability of the tadpoles made it difficult to distinguish the righting reflex from involuntary movements. | {
"entities": {}
} | [] |
One air embolism occurred; this was the only filter-or retrieval-related complication. | {
"entities": {}
} | [] |
The 5' region of ADH5 contains consensus binding sites for the transcriptional regulatory proteins, Sp1, AP2, LF-A1, NF-1, NF-A2, and NF-E1. | {
"entities": {
"gene": [
{
"text": "ADH5",
"start": 17,
"end": 21
},
{
"text": "Sp1",
"start": 100,
"end": 103
},
{
"text": "AP2",
"start": 105,
"end": 108
},
{
"text": "LF-A1",
"star... | [] |
These data indicate that RNK-Met-1 is a serine protease with unique activity that is expressed in the granules of large granular lymphocytes. | {
"entities": {
"gene": [
{
"text": "RNK-Met-1",
"start": 25,
"end": 34
},
{
"text": "serine protease",
"start": 40,
"end": 55
}
]
}
} | [] |
Purification and cloning of a novel serine protease, RNK-Met-1, from the granules of a rat natural killer cell leukemia. | {
"entities": {
"gene": [
{
"text": "serine protease",
"start": 36,
"end": 51
},
{
"text": "RNK-Met-1",
"start": 53,
"end": 62
}
]
}
} | [] |
We describe here 17 dominant GCN2 mutations that lead to derepression of GCN4 expression in the absence of amino acid starvation. | {
"entities": {
"gene": [
{
"text": "dominant GCN2 mutations",
"start": 20,
"end": 43
},
{
"text": "GCN4",
"start": 73,
"end": 77
}
]
}
} | [] |
Administration of growth hormone leads to faster growth, but also faster bone maturation. | {
"entities": {
"gene": [
{
"text": "growth hormone",
"start": 18,
"end": 32
}
]
}
} | [] |
Comparisons with the available amino acid residue (aa) sequence information from the complete CPMV RNA 1 sequence and the partial sequence of red clover mottle virus RNA 1 suggest that CPSMV RNA 1 specifies the expected set of five mature proteins: 32K proteinase cofactor, 58K presumed helicase, VPg 5'-linked protein o... | {
"entities": {
"gene": [
{
"text": "CPMV RNA 1 sequence",
"start": 94,
"end": 113
},
{
"text": "red clover mottle virus RNA 1",
"start": 142,
"end": 171
},
{
"text": "CPSMV RNA 1",
"start": 185,
"end": 196
... | [] |
In addition, the utility of beta 2 transferrin assay in the diagnosis of cerebrospinal fluid otorrhea is presented. | {
"entities": {
"gene": [
{
"text": "beta 2 transferrin",
"start": 28,
"end": 46
}
]
}
} | [] |
The addition of diatrizoate to the IPRK led to a dose-dependent biphasic change in RPF and GFR characterized by an initial transient increase followed by a marked and sustained decrease. | {
"entities": {}
} | [] |
To prepare for analyses with the family variables, we next present descriptive data based on separate principal components analysis (PCA) and multidimensional scaling analysis (MDS) of 14 self-reported health scores for husbands and for wives. | {
"entities": {}
} | [] |
The structural genes encoding glyceraldehyde-3-phosphate dehydrogenase (GAPDH), 3-phosphoglycerate kinase (PGK) and the N-terminal part of triosephosphate isomerase (TIM) from mesophilic Bacillus megaterium DSM319 have been cloned as a gene cluster (gap operon) by complementation of an Escherichia coli gap amber mutant... | {
"entities": {
"gene": [
{
"text": "glyceraldehyde-3-phosphate dehydrogenase",
"start": 30,
"end": 70
},
{
"text": "GAPDH",
"start": 72,
"end": 77
},
{
"text": "3-phosphoglycerate kinase",
"start": 80,
"end": 10... | [] |
Pseudomonas aeruginosa exotoxin A: its role in retardation of wound healing: the 1992 Lindberg Award. | {
"entities": {
"gene": [
{
"text": "Pseudomonas aeruginosa exotoxin A",
"start": 0,
"end": 33
}
]
}
} | [] |
Laboratory studies showed that the direct fluorescent-antibody kits were the least sensitive in this case and did not detect fewer than 10 (4) elementary bodies per ml, while most ELISA kits detected between 130 and 600 elementary bodies per ml. | {
"entities": {}
} | [] |
To study the significance of these domains and the overall evolutionary conservation of the gene, the homolog from Drosophila melanogaster was isolated by low stringency hybridizations using two flanking probes of the human ERCC3 cDNA. | {
"entities": {
"gene": [
{
"text": "human ERCC3 cDNA",
"start": 218,
"end": 234
}
]
}
} | [] |
Mono-ADP-ribosylation is a reversible modification of proteins, with NAD: arginine ADP-ribosyltransferases (EC 2. 4. 2. 31) and ADP-ribosylarginine hydrolases (EC 3. 2. 2. 19) catalyzing the opposing reactions in an ADP-ribosylation cycle. | {
"entities": {
"gene": [
{
"text": "arginine ADP-ribosyltransferases",
"start": 74,
"end": 106
},
{
"text": "EC 2. 4. 2. 31",
"start": 108,
"end": 122
},
{
"text": "ADP-ribosylarginine hydrolases",
"start": 128,
... | [] |
For this reason, the particle forming capacity of derivatives of the HIV-1 group specific core antigen p55 gag was assayed and compared dependent on various expression systems: recombinant bacteria, vaccinia-and baculoviruses were established encoding the entire core protein p55 either in its authentic sequence or lack... | {
"entities": {
"gene": [
{
"text": "HIV-1 group specific core antigen p55 gag",
"start": 69,
"end": 110
},
{
"text": "core protein p55",
"start": 263,
"end": 279
}
]
}
} | [] |
The tramtrack (ttk) gene of Drosophila encodes 69-kDa and 88-kDa proteins through alternative splicing of the primary ttk transcript. | {
"entities": {
"gene": [
{
"text": "tramtrack",
"start": 4,
"end": 13
},
{
"text": "ttk",
"start": 15,
"end": 18
},
{
"text": "ttk transcript",
"start": 118,
"end": 132
}
]
}
} | [] |
Removal of beta 2-microglobulin by hemodialysis and hemofiltration: a four year follow up. | {
"entities": {
"gene": [
{
"text": "beta 2-microglobulin",
"start": 11,
"end": 31
}
]
}
} | [] |
Removal of beta 2-microglobulin by hemodialysis and hemofiltration: a four year follow up. | {
"entities": {
"gene": [
{
"text": "beta 2-microglobulin",
"start": 11,
"end": 31
}
]
}
} | [] |
Adapromine was established to evoke a decrease of the amplitude of the dominant peak and dominant theta-activity in power spectra of the EEG in the cortex and hippocamp, with an increase of rapid wave activity in the beta 2 range in the right cortex and hippocamp. | {
"entities": {}
} | [] |
These sequences were then used to clone the full-length genes from a yeast genomic library. | {
"entities": {}
} | [] |
GAL4-VP16-mediated antirepression required an auxiliary factor, denoted as a co-antirepressor, which was partially purified from Drosophila embryos. | {
"entities": {
"gene": [
{
"text": "GAL4",
"start": 0,
"end": 4
},
{
"text": "VP16",
"start": 5,
"end": 9
}
]
}
} | [] |
After 28 days of haloperidol treatment, similar changes were observed for delta, together with an increase of alpha 1, and a decrease of fast beta. | {
"entities": {}
} | [] |
Four ruminally and duodenally cannulated Hampshire wethers were used in a 4 x 4 Latin square experiment to determine whether linoleoyl methionine and calcium linoleate would increase duodenal flow of unsaturated fatty acids (C18: 2 + cis C18: 1). | {
"entities": {}
} | [] |
Truncated ICSBP lacking the first 33 amino-terminal amino acids fails to bind to the ICS, indicating that at least part of the DNA binding domain is located within the well conserved amino terminus. | {
"entities": {
"gene": [
{
"text": "Truncated ICSBP",
"start": 0,
"end": 15
},
{
"text": "ICS",
"start": 85,
"end": 88
}
]
}
} | [] |
Therefore, ICSBP may be involved in maintaining submaximal transcriptional activity of IFN-inducible genes in hematopoietic cells. | {
"entities": {
"gene": [
{
"text": "ICSBP",
"start": 11,
"end": 16
},
{
"text": "IFN",
"start": 87,
"end": 90
}
]
}
} | [] |
A case of chronic hepatitis C with primary hypothyroidism manifested during interferon treatment | {
"entities": {
"gene": [
{
"text": "interferon",
"start": 76,
"end": 86
}
]
}
} | [] |
Dynamic decision making: human control of complex systems. | {
"entities": {}
} | [] |
A coiled-coil related protein specific for synapsed regions of meiotic prophase chromosomes. | {
"entities": {
"gene": [
{
"text": "coiled-coil related protein",
"start": 2,
"end": 29
}
]
}
} | [] |
Abstracts. | {
"entities": {}
} | [] |
These results indicate a possible involvement of endogenous opioid peptides in the cardiac effects due to myocardial ischaemia and reperfusion, mediated by opiate receptors through opiate antagonism. | {
"entities": {
"gene": [
{
"text": "opiate receptors",
"start": 156,
"end": 172
}
]
}
} | [] |
Since CENP-B gene is conserved in mammalian species and CENP-B boxes are found also in mouse centromere satellite DNA (minor satellite), this sequence-specific DNA-protein interaction may be important for some kind of common centromere function. | {
"entities": {
"gene": [
{
"text": "CENP-B gene",
"start": 6,
"end": 17
},
{
"text": "CENP-B boxes",
"start": 56,
"end": 68
}
]
}
} | [] |
Interestingly, a portion of the tail domain (aa, 1, 094-1, 830) shares 58% amino acid sequence identity with a 723-aa protein from mouse brain reported to be a glutamic acid decarboxylase. | {
"entities": {
"gene": [
{
"text": "glutamic acid decarboxylase",
"start": 160,
"end": 187
}
]
}
} | [] |
However, in the subgroup with normal Ht (< 0. 45 l/l; n = 201) there was a significant reduction (p < 0. 05) of the mortality after 3 months (27% and 16%, respectively) and an increase of independence at home (35% and 48%, respectively) due to a reduction of the viscosity by means of haemodilution with albumin (a speci... | {
"entities": {
"gene": [
{
"text": "albumin",
"start": 304,
"end": 311
}
]
}
} | [] |
Distribution and changing morphological course | {
"entities": {}
} | [] |
The appropriate use and benefits of bile acid sequestrants, nicotinic acid, fibric acids, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, and probucol are individually discussed, whereas nonpharmacologic approaches used in conjunction with the drugs are recommended emphatically. | {
"entities": {
"gene": [
{
"text": "3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase",
"start": 90,
"end": 147
}
]
}
} | [] |
This may result in more reabsorption and hence reduced renal clearance. | {
"entities": {}
} | [] |
The major pathological findings of the placenta were prematuration and hypoplasia. | {
"entities": {}
} | [] |
Green pepper significantly inhibited N-nitrosothiazolidine-carboxylic acid formation relative to ascorbic acid alone. | {
"entities": {}
} | [] |
A genomic clone, pTt21, containing DNA apparently transcribed specifically in Trypanosoma cruzi trypomastigotes, was obtained by differentially screening a genomic library with trypomastigote and epimastigote cDNA. | {
"entities": {}
} | [] |
Brucellosis--1990 | {
"entities": {}
} | [] |
Assay of urea by immobilized urease coupled to a differential pH-meter. | {
"entities": {
"gene": [
{
"text": "urease",
"start": 29,
"end": 35
}
]
}
} | [] |
RESULTS: In the AGA group, both fetal and maternal serum prolactin concentration increased significantly with gestation (P < 0. 001 and P < 0. 01, respectively). | {
"entities": {
"gene": [
{
"text": "prolactin",
"start": 57,
"end": 66
}
]
}
} | [] |
One phage clone contains a junction between alpha satellite DNA and a novel low-copy repeated sequence. | {
"entities": {}
} | [] |
The 5'-flanking region of the human lactoferrin gene was isolated from a human placental genomic library. | {
"entities": {
"gene": [
{
"text": "human lactoferrin gene",
"start": 30,
"end": 52
}
]
}
} | [] |
Therefore, the molecular mechanisms of the estrogen action that govern the lactoferrin gene expression differ between mouse and human. | {
"entities": {
"gene": [
{
"text": "lactoferrin gene",
"start": 75,
"end": 91
}
]
}
} | [] |
The CEM receives registration updates via an HL7 message and evaluates data dependencies in rules via an interface to the relational database. | {
"entities": {}
} | [] |
Magnetic resonance spectroscopy (MRS) and imaging (MRI) are now well established techniques for the study of cellular metabolism and gross structure of muscle. | {
"entities": {}
} | [] |
Simultaneously a greater NA was found with no change in plasma epinephrine response. | {
"entities": {}
} | [] |
We investigated the diagnostic value of a new in vitro test, Pharmacia CAP System (Pharmacia Diagnostics AB, Uppsala, Sweden), for the quantitative measurement of allergen-specific IgE antibodies by comparison with RAST in 2 groups of patients, 71 atopic and 48 non-atopic. | {
"entities": {
"gene": [
{
"text": "allergen-specific IgE antibodies",
"start": 163,
"end": 195
}
]
}
} | [] |
Patients receiving VPA showed differences in attention, visuomotor performance, verbal span and sensory discrimination tasks at T1, in visuomotor performance at T2 and in spatial span at T3, whereas no differences were detected at T4. | {
"entities": {}
} | [] |
We found that the gene segment containing the mu m poly (A) signals, along with 536 bp of downstream flanking sequence, acted as a transcription terminator in both myeloma cells and L cell fibroblasts. | {
"entities": {}
} | [] |
Alena is a nurse in Prague--she dreams of higher wages and a trip across the ocean | {
"entities": {}
} | [] |
Dopamine neurons in subjects that received 6-OHDA were protected by pre-treatment with GBR-12909. | {
"entities": {}
} | [] |
The results of this study demonstrate that strongyloidiasis was the cause of sudden death. | {
"entities": {}
} | [] |
A second large group of disorders in pregnancy is caused by effects of infections of the mother without pathogens being transmitted to the embryo or the placenta. | {
"entities": {}
} | [] |
Four short nucleotide sequences (boxes I to IV) contribute to the light responsiveness of the parsley chalcone synthase promoter. | {
"entities": {
"gene": [
{
"text": "parsley chalcone synthase promoter",
"start": 94,
"end": 128
}
]
}
} | [] |
The case described is that of a 72-year-old man with ochronosis who suffered a hyperextension injury to his spine in a fall, resulting in a fracture through an ankylosed L2-L3 disk space. | {
"entities": {}
} | [] |
The mean blood flow in the penile foreskin was estimated to be 15 ml/min/100 g and it increased to 150-200% after the induction of anesthesia, and then decreased to 72% at the tip of the created parameatal foreskin flap. | {
"entities": {}
} | [] |
Exogenous LHRH is also known to facilitate mating behavior in several species. | {
"entities": {
"gene": [
{
"text": "LHRH",
"start": 10,
"end": 14
}
]
}
} | [] |
The first 146 consecutive patients treated with EVL during the period from August, 1986 to July, 1989 are reported. | {
"entities": {}
} | [] |
Replacing the aspartic acid with a lysine but not with an alanine or valine residue allowed formation of disulfide-linked dimers. | {
"entities": {}
} | [] |
During V-A bypass, hemodynamics were stable. | {
"entities": {}
} | [] |
Greater rupture force was required in the adult pigs than in the young pigs. | {
"entities": {}
} | [] |
At rest AFF was significantly higher in UT (29%) as compared to AT (25%) and UEA (25%). | {
"entities": {}
} | [] |
We investigated the smoking habits of relapsers 1 year after quitting in a smoking cessation trial using nicotine or placebo patches. | {
"entities": {}
} | [] |
Exposure to hepatitis B virus in the general population of Hisayama, Japan: significance of isolated antibody to hepatitis B surface antigen in general population. | {
"entities": {
"gene": [
{
"text": "hepatitis B surface antigen",
"start": 113,
"end": 140
}
]
}
} | [] |
Because of this latter phenomenon, we were able to identify a particular cysteine motif that was repeated multiple times in Dfurin2 but present only twice in mammalian furin. | {
"entities": {
"gene": [
{
"text": "Dfurin2",
"start": 124,
"end": 131
},
{
"text": "mammalian furin",
"start": 158,
"end": 173
}
]
}
} | [] |
On the other hand, neither phosphate buffered saline injection into the ES nor primary KLH challenges of the ES were capable of elevating the threshold level and changing the latency. | {
"entities": {
"gene": [
{
"text": "KLH",
"start": 87,
"end": 90
}
]
}
} | [] |
A newly developed broad-spectrum fluoroquinolone, levofloxacin (LVFX, DR-3355), was evaluated in vitro and in vivo in comparison with ciprofloxacin (CPFX), ofloxacin (OFLX) and norfloxacin (NFLX). | {
"entities": {}
} | [] |
The mean serum creatinine levels were similar at one year (SPK 1. 8, KTA 1. 9 mg/d). (ABSTRACT TRUNCATED AT 250 WORDS) | {
"entities": {}
} | [] |
Model predictions were in accord with the nine-year survival experience of women in the HIP trial, and, with the exception of women 40-44 years old, with HIP data on 18-year survival. | {
"entities": {}
} | [] |
High-resolution computed tomography in the diagnosis of miliary tuberculosis. | {
"entities": {}
} | [] |
Previously, we showed that SNF2, SNF5, and SNF6 function interdependently in transcriptional activation, possibly forming a heteromeric complex. | {
"entities": {
"gene": [
{
"text": "SNF2",
"start": 27,
"end": 31
},
{
"text": "SNF5",
"start": 33,
"end": 37
},
{
"text": "SNF6",
"start": 43,
"end": 47
}
]
}
} | [] |
We show that LexA-GAL4 and LexA-Bicoid fusion proteins are both dependent on SNF2, SNF5, and SNF6 for activation of target genes containing one or multiple lexA operators. | {
"entities": {
"gene": [
{
"text": "LexA",
"start": 13,
"end": 17
},
{
"text": "GAL4",
"start": 18,
"end": 22
},
{
"text": "LexA",
"start": 27,
"end": 31
},
{
"text": "Bicoid",
"start... | [] |
George T. | {
"entities": {}
} | [] |
A lambda gt10 cDNA library was constructed from poly (A) + RNA of young green leaves of spinach. | {
"entities": {}
} | [] |
NE and PR3 assist in the destruction of phagocytosed microorganisms, cleave the important connective-tissue protein elastin, and generate chemotactic activities by forming alpha 1-proteinase inhibitor complexes and elastin peptides. | {
"entities": {
"gene": [
{
"text": "NE",
"start": 0,
"end": 2
},
{
"text": "PR3",
"start": 7,
"end": 10
},
{
"text": "connective-tissue protein elastin",
"start": 90,
"end": 123
},
{
"text": ... | [] |
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