Entry stringlengths 6 10 | EC number stringclasses 260
values | Active site stringlengths 0 544 | Sequence stringlengths 20 2.05k | labels int16 1 260 |
|---|---|---|---|---|
A0CN86 | 3.2.1.52 | ACT_SITE 309; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001093-1" | MIFVQLFFLAVNAIMPMPNSIIQGYQTARISSICQVKFFSNQEFPDHVIQLLLHYHELITQDEDCEFEESIQNTNIKIEGALKFEISIENYEQLYWVTSTKEEAYELQIDENLNVKIQAKNHWGLARALDTVNQLAINNEIQNLPIQISDEPQYVHRGIMIDTARNYLPVKLIKRTIDALVINKLNVLHWHITDDESFPLLLSKYSQITNNSKFWKDGFFTKKDVQEIIEYASIRAVQIIPEIDTPAHVHSWGISPDLQSIVITCDTNIRQYGQLDPTLDQTYEVLTSILQDLNDMFDKVQFIHFGGDEASNQCFEQKPS... | 170 |
Q9C7S5 | 2.7.11.1 | ACT_SITE 929; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MIDEKMRSKSIGPFVRQVKPLSPHMVLFVLLYVLSISVFFLTVSEAVCNLQDRDSLLWFSGNVSSPVSPLHWNSSIDCCSWEGISCDKSPENRVTSIILSSRGLSGNLPSSVLDLQRLSRLDLSHNRLSGPLPPGFLSALDQLLVLDLSYNSFKGELPLQQSFGNGSNGIFPIQTVDLSSNLLEGEILSSSVFLQGAFNLTSFNVSNNSFTGSIPSFMCTASPQLTKLDFSYNDFSGDLSQELSRCSRLSVLRAGFNNLSGEIPKEIYNLPELEQLFLPVNRLSGKIDNGITRLTKLTLLELYSNHIEGEIPKDIGKLSK... | 99 |
F0ZUU2 | 2.3.2.26 | ACT_SITE 1434; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MRNLSGALLDELQTPLRGGNPAAVGLLNTLIEGRNRSKLLLQGLKSDDENKQMESLLEVCDLLSIATEETIAGFPSDSFAPALINLLNMDHNPDMMLLAGRALSNMIEALPSSISSVVNHGAVSILCSKLLSIEYIDLAEQCLQTLEKISQEQPTVVLRAGGLMATLSFIDFFSTGVQRMAITTASNICRQVPKDCFDMVREPIQILTNLLQYQDQKVVELSCLCFSRLIESFYDSPQKLEIIASHGLISNLVRIISGMYNSTTSLSPNTYSQIIRIMATVCHGCPNITQTLLEEGIISIIQSIMYPSNDNANGSNSNVN... | 65 |
Q8C0V0 | 2.7.11.1 | ACT_SITE 586; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MSVQSSSGSLEGPPSWSRLSTSPTPGSAAAARSLLNHTPPSGRPREGAMDELHSLDPRRQELLEARFTGVATGSTGSTGSCSVGAKASTNNESSNHSFGSLGSLSDKESETPEKKQSESSRGRKRKAESQNESSQGKSIGGRGHKISDYFEYQGGNGSSPVRGIPPAIRSPQNSHSHSTPSSSVRPNSPSPTALAFGDHPVVQPKQLSFKITQTDLTMLKLAALESTKNQDLEKKEGRIDDLLRANCDLRRQIDDQQKLLEKYKERLNKCISMSKKLLIEKSTQEKLSSREKSMQDRLRLGHFTTVRHGASFTEQWTDGF... | 99 |
Q9LZV4 | 2.7.11.1 | ACT_SITE 308; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MASLLSPATPTATSAAFHSCSTAGFSTPTHISSQNSSLSLLSRRGCMMRCSFSPQDIPVDSLSHLPPFLDFQNSLATFSDTQKWGFFVSAGIVWFYLTARPGVLIGAIDAYLLAPLQLGLDTLIGRRLKRSDFLVTEKLGEGSFGVVYAGVLLPKNSTLVDDVRVSKARAKAMDFTGEFKQRVILKKVKVGVRGAEEFGEYEEWFNYRLSRAAPDTCAEFLGSFVADKTNTMFTKGGKWLVWRFEGDRDLADYMKDRSFPSNLESIMFGRVLQGVESVKRRALIIKQIMRQIITSLRKIHGTGIVHRDVKPANLVVTKKG... | 99 |
B9RZW1 | 2.3.2.26 | ACT_SITE 1002; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MFFSGDPTTRKRVDLGGRSSKERDRQKLLEQTRLERNRRLWLRQQNASAIKIQKCFRGRKAVEIERSKVRDQFYQTYGKHCQNVDWHCFGPDSEFLRQLFFFFNAQNSGDFAVLVETCQRLLQFVRDGGDIISLFGGIDYSTNRALVDYRVKQLSFCCIQAVYQNREQLKNQLLMTLWESSEPVAVLLEVVVLLIDQKLPWACKIVGYLFQRNAFNLCREIVLVAKENMKACNFTGKLSSLERMLSLIISHIGQKPCICPHIDPQCSFISQILTIPFLWRLFPSLKEVFATRGLSEHYIHQMALCVGGNANVLPNDVSVE... | 65 |
P00634 | 3.1.3.1 | ACT_SITE 124; /note="Phosphoserine intermediate" | MKQSTIALALLPLLFTPVTKARTPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPT... | 141 |
P16911 | 2.7.11.1 | ACT_SITE 168; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MSQHTSQYVFNSKEDYNVILDNMSREFEERWNHQTQSPYTNLENYITRAVLGNGSFGTVMLVREKSGKNYYAAKMMSKEDLVRLKQVAHVHNEKHVLNAARFPFLIYLVDSTKCFDYLYLILPLVNGGELFSYHRRVRKFNEKHARFYAAQVALALEYMHKMHLMYRDLKPENILLDQRGYIKITDFGFTKRVDGRTSTLCGTPEYLAPEIVQLRPYNKSVDWWAFGILVYEFVAGRSPFAIHNRDVILMYSKICICDYKMPSYFTSQLRSLVESLMQVDTSKRLGNSNDGSSDVKSHPWFQGVDWFGILNQEVTAPYQP... | 99 |
A6KQT9 | 3.4.21.92 | ACT_SITE 210; /evidence="ECO:0000256|PROSITE-ProRule:PRU10085"; ACT_SITE 235; /evidence="ECO:0000256|PROSITE-ProRule:PRU10086" | MGQRRGFSLFIRTPINEDPTHRLTPPSSAPPISFSEVDEPAAPAKHAGCCSSGNQAWMHGGMWPRVLLRDGRAAAGGCRALLSRFAVRFSPPWSTGSDSPLRSNLHGTATRAFPLIPIVVEQTGRGERAYDIYSRLLRERIVCVMGPIDDSVASLVIAQLLFLQSESNKKPIHMYINSPGGVVTAGLAIYDTMQYILNPICTWCVGQAASMGSLLLAAGSPGMRHSLPNSRIMIHQPSGGARGQATDIAIQAEEIMKLKRQLYNIYAKHTKQSLQVIESAMERDRYMSPMEAQEFGILDKVLVHPPQDGEDEPELVQKET... | 179 |
Q8PBR6 | 6.3.4.4 | ACT_SITE 14; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00011"; ACT_SITE 42; /note="Proton donor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00011" | MGQSVVVLGAQWGDEGKGKIVDLLTEEIGAVVRFQGGHNAGHTLVINGKKTVLHLIPSGILRDDALCLIGNGVVISPAALIKEIGELESAGVEVRSRLKISPAAPLIMPYHIALDQAREKAAGGKAIGTTGRGIGPAYEDKVARRGIRIADLHYPAQLEELLRTALDYHNFVLTKYLGVEAVDFQKTFDEALAFGEYVQPMKSDVAGILHDLRKQGKRVLFEGAQGALLDIDHGTYPYVTSSNTTVGGALAGTGVGADAIDYVLGIAKAYATRVGGGPFPTELDDEVGQGIRDRGAEYGASTGRPRRCGWMDIVALKRAV... | 253 |
P35832 | 3.1.3.48 | ACT_SITE 682; /note="Phosphocysteine intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00160, ECO:0000255|PROSITE-ProRule:PRU10044" | MPRPQHHALLRAMLKLLLFASIAEHCATALPTNSSNSPSSPSPFTVASLPPTTASSSSSPAVISTSSFDRNLADLVNPEAETSGSGWESLETEFNLATTVDSSTQKTAKEPVLGTAATSIEQQDQPPDVPATTLAFANAFPVPVAGEMGNGNGNYNDATPPYAAVDDNYVPSKPQNLTILDVSANSITMSWHPPKNQNGAIAGYHVFHIHDNQTGVEIVKNSRNSVETLIHFELQNLRPYTDYRVIVKAFTTKNEGEPSDQIAQRTDVGGPSAPAIVNLTCHSQESITIRWRRPYEFYNTIDFYIIKTRLAGQDTHRDIR... | 149 |
Q6C9C2 | 2.7.7.7 | ACT_SITE 449; /note="Nucleophile; Schiff-base intermediate with DNA; for 5'-dRP lyase activity"; /evidence="ECO:0000256|PIRSR:PIRSR622312-50" | MGPRATRNSSKNTEGAETASKDAQSQHNAASDTKQASKEVSSTATSPKVALKRQHRTAASTNSDESSSKPSTPTGSVTSTVESPRKAKKTDAVVEGEQPETTVKQEPDFESTVKIEPIEVVKTEDPGHDIKVEDRDIKTEEDTKAGGNASREEIKNEYHSTPNLPLFHAITVMFIPLSKTNKHRAELCSRHGGTVVTSYSDKVTHIIVANGVTVPQLMKTLGVDTLPASVTVVNENWFADCIEAGKIVGFGGKEVLGVPRGGDKRTAETTSDDTDAKKRRRASDAPSRSTTPPASPKSRSELRSDVSSDVIKARGKSMLE... | 121 |
Q8WTX9 | 2.3.1.225 | ACT_SITE 164; /note="S-palmitoyl cysteine intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00067" | MYKMNICNKPSNKTAPEKSVWTAPAQPSGPSPELQGQRSRRNGWSWPPHPLQIVAWLLYLFFAVIGFGILVPLLPHHWVPAGYACMGAIFAGHLVVHLTAVSIDPADANVRDKSYAGPLPIFNRSQHAHVIEDLHCNLCNVDVSARSKHCSACNKCVCGFDHHCKWLNNCVGERNYRLFLHSVASALLGVLLLVLVATYVFVEFFVNPMRLRTNRHFEVLKNHTDVWFVFLPAAPVETQAPAILALAALLILLGLLSTALLGHLLCFHIYLMWHKLTTYEYIVQHRPPQEAKGVHRELESCPPKMRPIQEMEFYMRTFRH... | 57 |
A0A0A0KC15 | 3.1.3.16 | ACT_SITE 352; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR033096-1" | MSNNNSNVTPAEKIKCRANKAFAAHKYAQAIDLYTQAIELNNQNAIYWANRAFAHIKLEEYGSALEDASKAIEVNPRYSKGYYRRGAAYLAMGKFKEALKDFQQLKKMCPNDPDTIQKLKECEKAIGKLNSEEAVAAPLPETDSVANSIDVHRVGVSSTSVPTQMAIVAAAVATTAIAISTLSTKVATVVAAIAVVVLIIMGTRWWGGSGCVINAKTLDVDPQYSGARIEGDIITLDFVKKMIDNFKNQKPLHRRYVFQILQQTKKILKALPSLVDITIPEGKRLTVCGDVHGQFYDLLNIFELNGLPSEDNPYLFNGDF... | 144 |
Q8RHB2 | 5.6.2.2 | ACT_SITE 118; /note="O-(5'-phospho-DNA)-tyrosine intermediate"; /evidence="ECO:0000256|HAMAP-Rule:MF_01897" | MSNVDNRYIEEELKESYLDYSMSVIVSRALPDVRDGLKPVHRRILFAMNEMGMTNDKPFKKSARIVGEVLGKYHPHGDSAVYGTMVRMAQDFNYRYLLVEGHGNFGSIDGDSAAAMRYTEARMEKITAELLEDIDKDTIDWRKNFDDSLDEPTVLPAKLPNLLLNGAIGIAVGMATNIPPHNLGELVDGILAIIDNKDIEILELMNYIKGPDFPTGAIIDGRVGIIDAYKTGRGKIKVRGKVDIEELKNGKSNIIVSEIPYQLNKANLIEKIANLVKEKKITEISDLRDESNREGIRILIEVKKGEEPELVLNKLYKYTD... | 222 |
Q8P8H6 | 3.1.1.11 | ACT_SITE 256; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MSASHIRTTCLATALLSLISLDAAALTGTASRPQLTSSEAGTYTISKALAKAGPITALVTDNWNPTAGVALLTADFAVAADGSTRYRTVQSAIDAAVAAGGSTRRYISVKAGTYTELVCVPSGAPPLTLFGLGSATTDTVIRYNNANPTPKPTGTASHPCASNASAATVGTSNSATVTVRASGFQARHLRFDNNYVEGTYADNNQSAVALAVRGDQASFEDVLVTGNQDTLLISATNAANVIRAYFKSSTIEGDVDFIFGSGIGVFDNAIIRSAGARLGSSRGGYIFAPSTRPGSGYGFLAINSRFVAGSGSPDNQTYLG... | 125 |
A0A6P9EVX0 | 3.1.1.11 | ACT_SITE 422; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MTQIKELLTGKLQISHNYISVVKRKKKLVLAFSVTLLLVAAIVGIAAGVHSRGKNSGNRELSASAHAIVKSSCSSTLYPDLCYSALASVPGASAKLSSQKDVIEASLNITTEAVEHNFFTVKKLIKTRKDLTKREKTALHDCLETIDDTLDELHQAVEDLHEYPNKKSLSLHADDLKTLISSAITNQETCLDGFSHDEADKRVRKVLLAGQVHVEHMCSNALAMIKNMTDTDIANEGKTTSRKLKEEVDGVKWPEWLSAADRRLLQSSSVTPDAVVAADGSGDYKTVSEAVAAAPDNSKTRYVIRIKAGVYRENVEVTKK... | 125 |
A0A9R0HUN7 | 1.11.1.7 | ACT_SITE 64; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MAISAAVVFSSILIFSAFSLGNALSLNHYVKACPEVENIIKNAVTEGFHKDKTVPAALLRLHFHDCFIRGCDASVLLDKDENNKVEKSGPPNLSLHAFFVIDNAKKAVEAACPGVVSCADILALAARDAVVAAGGPNWDVPKGRKDGRTSLASDTLQLPAPTFNLSQLQQSFARRGLNLGDLVALSGGHSLGFSHCSSFQNRLHNFDAAHNIDPSINPSFAANLNKVCPAHNKVKNAGSNMDPSPTLFDNTYYKLILQGKSLFSSDQALFTAPSTKHLVYKYAGSKEAFYKAFVKSMIKMSSITGGQEIRKHCRKVNS | 14 |
A0A0K9PT86 | 5.1.3.15 | ACT_SITE 168; /evidence="ECO:0000256|PIRSR:PIRSR016020-1"; ACT_SITE 272; /evidence="ECO:0000256|PIRSR:PIRSR016020-1" | MAESEEFLFMEKCKGVNGIDKIVLRQGRGISVEIYLYGAHVTSWKNDGEELLFMSSKTNFKPPKPIRGGIPICFPQFSDMGNLDKHGFARNKFWSIDDDPPSFPAMPSHKAFVDLILKPSGEDLRIWPHSYEFRLRIILGPGGDLMFTSRIKNTNTDGKPFSFKFAFHTYFSVSDISEVRVEGLETLDYLDNLKNRDHYTEQGDSIMFESEIDKIYLDTPSKIAIIDHGQKKTLVLKKEGLPDAVVWNPWEKKAKSLVDFGDDEYKTMLCVEAAAIEKSIVLKPGEEWQGKMDLMVNFSSYSSGYLDPKSAVL | 210 |
A0A251VRS6 | 3.1.1.11 | ACT_SITE 253; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MNTKKSILFWLSVIAIALFSIILSFYTTNSTIPTFEVTFVKRVIEQSGFYDLFSFISQITGRHRHHGHHHHHHRRRKVSCDADTWKNSRLISEYGVQLVLTVDQNGCGNFTTLQQAVDAVPDSSLNTTLIILDSGTYREKVLVNQTKTNLIIQGQGFLNTAIAWNDTANSTGGTIYSATVSVFAQNFIAYNISFKNTAPSPAQGVVGAQAVALRISGDQAAFYGCGFYGAQDTLLDDRGRHYFKECFIEGSIDFIFGNGRSLYEGCMLHSVASDVPSGGGISGAITAHGRNSVDEKTGFSFVYCIIRGSGRVWLGRAWGA... | 125 |
A0A9J7MKE3 | 2.4.1.18 | ACT_SITE 347; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR000463-1"; ACT_SITE 402; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR000463-1" | MATKMDVDEDVGPAPPDLNRLYDLDSYLKPFDKEIKRRYKCFVEVLEHINQHEGGLEKFSRGYENFGIHVTEDGGLVMREWAPGAVELYLMGDFNGWNKTSHSFEKKPFGKWELVLPPKDDGSCPLDHLSKYKLVVKDKNGHLLERICPWAKYTIPSNETKIYEAMFWNPPEKYVFQQSRPATPRSLRIYESHVGISSWEGKVADYKHFAYNVIPRIKKQGYNCIQMMAIMEHAYYASFGYQITSFFAASSRYGPPDDLKLLIDTAHKEGITVLLDVVHSHASKNVLDGLNQFDGTNACFFHAGSRGNHDLWDSRCFDYT... | 73 |
P05653 | 5.6.2.2 | ACT_SITE 123; /note="O-(5'-phospho-DNA)-tyrosine intermediate"; /evidence="ECO:0000255|HAMAP-Rule:MF_01897" | MSEQNTPQVREINISQEMRTSFLDYAMSVIVSRALPDVRDGLKPVHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSVDGDSAAAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDITIPELMEVIPGPDFPTAGQILGRSGIRKAYESGRGSITIRAKAEIEQTSSGKERIIVTELPYQVNKAKLIEKIADLVRDKKIEGITDLRDESDRTGMRIVIEIRRDANANVILNNL... | 222 |
Q39183 | 2.7.11.1 | ACT_SITE 316; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MASTRKPSGHGAEVEAQKRSSSNSSTKSAKAETFEPMQLQRSVTNPRAVGIPESKRLPESFRKRSSDPAVCKPDFSSLSTVLEHVDSLTIDEKKTSGFGSVKTSSASAKLSDGTSSLGKTSGSAKLSGRLDFMESGKSSICRGSTSSDVSDESSCSSFSSTVNKPHKANDLRWEAIQAVRVRDGLLGLSHFRLLKRLGCGDIGSVYLSELSGTKCYFAMKVMDKTSLASRKKLLRAQTEREILQSLDHPFLPTLYTHFETEKFSCLVMEFCPGGDLHTLRQRQPGKHFSEQAVKFYIAESLLALEYLHMLGIVYRDLKPE... | 99 |
A0A1U7YTJ2 | 5.1.3.3 | ACT_SITE 192; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1"; ACT_SITE 324; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1" | MANLSQLLCFIFVAFALLHVSSANEANVGIYQIKKGNFYVNLTNWGARITSIVLPDKQGNLGDIVLGYDTLDEYKTDTSYFGAIVGRVANRIKGAQFTLNDTTYNLVANDGKNTLHGGQKGFSDVVWQVKKHSPASHCPYVRFHYQSADGEQGFPGKVIVSVNYMITVENQLSVTMKAKALNKATPVNLAQHTYWNLGGHNSGDILSETLQIFASQYTPVDSELIPTGEIAPVKGTPYDFGEPQTVGSRIDQLPNGYDINYVVDAEGGPRTMKKAAILSDSKSGRVMELRTSAPGLQLYTADKLKDIKGKNGAVYKPHAG... | 211 |
Q6DHD6 | 5.1.3.3 | ACT_SITE 173; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1"; ACT_SITE 307; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1" | MTEVHKEEFGTALGPVERWILRSASVSVEIISLGCVIKSIKTADRSGQSADIVLGFDDIEGYFSNPRYFGAVVGRVANRISKGRFVIDEKEYKLAINNGPNALHGGLKGFDKAVWSTEAVDNGVKLSHSSPDGDEGYPGNLKVSVTYTLEKSTLSVLYHAQTDHTTPINLTNHSYFNLAGEGTPDIYDHEVTISAESYLPVDDTVIPTGEVKPVEKTPFDLRKPVILGFRLKELSGPGFDHNFCLYLPGEPPLERKCARVVHPGTGRVLEVSTTQPGVQFYTSNFLDGSVKGKGGAAYSKHSAFCLETQNWPDAVNQPHF... | 211 |
H3GWW5 | 2.3.2.26 | ACT_SITE 643; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MDNERSTEASMLYQGVGMLLLCIIFFVVWLMACRRNRHLLDMEVPLLSGESVDHRIDAATREAEAGYSVCASCAFENFKRFEYCVLCGDKLPSLSFATADDESDDEQLKPEDTCSSRGGAINMAMSATHLLSPRPRKMSSLSRQQRRARSRREWTRKLDVEGNLFWYRSGGGGHVPANSDVDTLLPGYTLSFKLPEEVEQQELAEEQEQERTKEQEEQETMTETEPVPSLAVEQPQSEKENADDKPMLPTDVELELVEASVSDPADFATGKSTLADAGAERRKEVVSLATSDFPSKYAHFVVSTASLIVPAEVEFLKLSV... | 65 |
A0A022RLC9 | 3.1.1.11 | ACT_SITE 347; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MQSRIEGHDVHTPQTVLKAALQNTIKEAMLAIDTISTFNTLSISYREQIAIEDCKELLDFSVSELTWSLSEMNKIRAGSKNPRSDGNLKAWLSAALSNQDTCLEGFEGTDRRLERFVRGSVSQVTQLIGNVLTLYVQMHRLPFRPPRSYTNATSTNYDDDNNGDENGDGRDFPTWMTDGDKELLVSERSNNNNGMHVDSVVALDGSGRYRSIGQAIFEAPSYSKRRYVIYVKKGVYQENIDMKKKKSNIMLVGDGIGKTIITGNRNFMQGWTTFRTATLAVSGKGFIARDMTFRNTAGPEKHQGVAIRVDSDQSAFYRCS... | 125 |
A0A0D1BX81 | 3.4.25.1 | ACT_SITE 45; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR600243-1" | MSAAMAHAFPGSSTSSSGFDFSNYSRNTFLSNQGLGGFTATSTGTTIVGCIFKDGVVLGADTRATEGPIVADKNCEKIHYISDNIRCCGAGTAADTEFVTQLISSNMQLHELNTGRQPRVVTAMTMLKQRLFQYQGHIGAALVLGGYDATGPHLFTVAPHGSTDKLPYVTMGSGSLAAMAVFESGWVKDMERADAIGLVAAAISSGIFNDLGSGSNVDVCVIEKGKTEYLRNYETPNERVSKEQRYQFPRGTTAFTKQQIYDMIRKEDVLEIGNKAAVPVPAAAPGEERMDTS | 180 |
Q0U8Y6 | 3.1.3.3 | ACT_SITE 174; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR604469-1"; ACT_SITE 176; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR604469-1" | MATRPPALDVSPTHLVATLFYKSDSPHFFQHADLSPRSPNDQLPSASLEALKDGAAPTENLADYPLEPPTPGPSALDNLYGSYLSQSCLTDFFVTLTNILPGLEQSTITSRKLEAAKLCRVVEVTFPLPSASPIALETLRRDEAVSRFEREWNVECVFQADNIYRRYKRLAVFDMDSTLIQQEVIDEIASLIGVEKEVSAITAAAMNGELDFEASLRARCKLLKGVPSTVFETLRPRITLNEGVKELITGLKKLGFKTAVLSGGFTPLTSWMGQQLGLDYAFANHLVVSEDGKTLTGELTGEIVHAQKKRQHVLEIAEKE... | 147 |
Q9FM79 | 3.1.1.11 | ACT_SITE 221; /note="Proton donor"; /evidence="ECO:0000250|UniProtKB:P0C1A9"; ACT_SITE 242; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:P0C1A9" | MKVEAFIPAVLLLCFGVMLCLKSSCALQIGNNNELKNYISWEDLRVVEDGRIERSFSIKENSNWVTTNANANANATNVRRVIVVDKNGGGDSVTVQGAVDMVPDSNSQRVKIFILPGIYREKVIVPKSKPYISFIGNESYAGDTVISWSDKASDLGCDGKELGTYRTASVSIESDFFCATAITFENTVVAEAGEQGRQAVALRIIGDKAVFYRVRVLGSQDTLFDDNGSHYFYQCYIQGNVDFIFGNAKSLYQDCDIHSTAKRYGAIAAHHRDSETEDTGFSFVNCDISGTGQIYLGRAWGNYSRTVYSNCFIADIITPV... | 125 |
Q9X0I1 | 6.3.4.4 | ACT_SITE 12; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00011"; ACT_SITE 40; /note="Proton donor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00011" | MNRVVVGLQWGDEGKGKVVTYLSRYHDIVARFSGGANAGHTVNYGDFKVIHHLLPSADFTKNRGIAIGSGVLLDPQVLTEELRELKEKFPDYSGEIFISESAHVVLPVHKEMDRIIDEVLKIGTTKRGIGPACADRVMRVNVRVAELGNEEKLRYFLEKNLSLKKIYGVDFDAEKMMGDLSTFYETIKDFVVSPVQLKRILEEKSVLFEGTQGVLLDLDVGTYPYVTSMNCSSSGVSAGMGFPVEVDEVLGVFKAYTTRVGEGPFPTELTGEEGEKLRKAGHEYGSTTGRPRRCGWLDLPLLRYAIEISGVDSLVMTKAD... | 253 |
A0A3Q7IKN3 | 6.3.4.4 | ACT_SITE 638; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03125"; ACT_SITE 684; /note="Proton donor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03125"; ACT_SITE 784; /evidence="ECO:0000256|PROSITE-ProRule:PRU10134" | MQMRQKLLFRSSPAICPHIVWGFVPVCLKHHINPVKHKLLHTSCQLILQSRGKRFGFLVNCLNGTIENSNNEQQTCYRNGEEISYDLYNESICELCTEGDIDKAMRLLSEMEALGFHPSFVSYSSLIAALGSVGRTSEADAIFQEMLCSSRKPRIKVFNILLRSFLRKGLLRLADKVLMLLDDLAVDRNQETYEILLEYYVSAGRLEDTWLIVAKMRRESYPLNSFVYSKIIELYRDNGMWKKALGIVEEIREMGLRLDKRLFNSIIDTFGKYGELGEALGMFDKMRQEGIKPDFRTWNSLIRWHCKYGHLDTAIELFNE... | 253 |
A0A6I8NK18 | 3.1.4.11 | ACT_SITE 327; /evidence="ECO:0000256|PIRSR:PIRSR000956-1"; ACT_SITE 374; /evidence="ECO:0000256|PIRSR:PIRSR000956-1" | MSLLSPILLPPEVKSYLSRGERFIKWDDDTTLASPVILRVDPKGFYLYWTYQSKEMEFLDITSIRDTRFGKFAKMPKTQKLREVFNLDFPDNTFLLKALTVVSGPDMVDLTFHNFVSYKENVGQTWAKDVLTLAKDPLTANASRSTFLEKILVKLKMQLNPEGKIPVKNFFQMFPADRKRVEAALSACHLAKGKNDSINPEDFPEPVYRSFLMNLCPRPEIDEIFTSYHAKAKPYMTKDHLTEFINKKQRHSGLNSLLFPPARPEQVQGLIDKYEPSGLNIQRGQLSPEGMVWFLSGPENSVVAQDKLLLHQDMSQPLNH... | 153 |
Q9V4E5 | 2.7.10.1 | ACT_SITE 868; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000666-1" | MKMVGCHPNDKKVKYDGIKSKTSSVTILTSVLNDAISALKSAFYKNQAPISEQNRSQIVSRMSLLRTILLIIISIHFKLAHADQVVLLDTTREATLEWTRYPYGPQAQTPGWVEESFTDFVKGINWRSYVVCDVAYHNVNNWLWSPFIDRGSANRLYIEIQFTIRDCSLFPGNALSCKETFSLLFYEFDAATREPPPWQTDSYRLIARIAAGEGRFNQNSDVDINTEVKSIAVNKKGVYFAFRDQGACISVLAVKVYYITCPAVTENFAHFNETPTGREITIIEKQNGTCVDNAEPYETPTYLCKGDGKWTILTGGCRCK... | 97 |
Q2UIM2 | 3.2.1.55 | ACT_SITE 229; /note="Nucleophile"; /evidence="ECO:0000250"; ACT_SITE 305; /note="Proton donor"; /evidence="ECO:0000250" | MSSGLSLERACAVALGIVASASLVAAGPCDIYSSGGTPCVAAHSTTRALYSAYTGALYQVKRGSDGSTTDIAPLSAGGVADAAIQDSFCANTTCLITIIYDQSGRGNHLTQAPPGGFNGPESNGYDNLASAVGAPVTLNGKKAYGVFMSPGTGYRNNAASGTATGDKAEGMYAVLDGTHYNSACCFDYGNAEVSNTDTGNGHMEAIYYGDNTVWGSGAGSGPWIMADLENGLFSGLSSTNNAGDPSISYRFVTAVVKGEANQWSIRGANAASGSLSTYYSGARPSASGYNPMSKEGAIILGIGGDNSNGAQGTFYEGVMT... | 171 |
W5NJ28 | 3.1.3.48 | ACT_SITE 1116; /note="Phosphocysteine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR000934-1" | MPFRLKLCRTRRYNVLSKNCFVTRIHLLDNNVIECTLSVESTGQECLEAVAQRLELRETHYFGLWFHSKSQLQRWVELEKALKKQLDKFGNEPLLFFGVMFYVPNVSRLEQEVTRYQYYLQVKKEVLDGRLQCTVEQGIRLAGLAVQADFGDFNHFQSQDFLREYVLFPVKWTQDEEVLEELTQKVAEEHKSHCRMPPAEAELLYIKEVERLEGFGQESFTAKDNFASDIYLGVSFMGVFVKHRNGRSTIVYRWNDIGNITHNKSAITIELTNKEETVLFHTDDMEMAKYISRLFTARHKFYKQNKICTEQSNSPAPIRR... | 149 |
F6HGE3 | 1.11.1.7 | ACT_SITE 92; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MHFSTPSCFLLPILALLLISASSAQYEEHEEELTDPLTYLENPSLNEMLPGLSFSYYRQTCPDLEAIINRKVKEWIDKDYTLAASLIRLHFHDCAVKGCDASILLDHPGSERWADASKTLRGFQVIDDIKAEVERKCPKTVSCADILTAAARDATILSPAPGDATGLDLVRVPFWMVPYGRKDGRVSIDKEAQTVPMGRENVTALLEFFQSKGLNVLDLVVLSGAHTIGRTTCGAMQHRLYDFHGTGEPDPSISPKYLKFLRRKCRWASEYVDLDAITPRTFDVMYYKNLQHNMGLLATDQMLGSDSRTSDLVATLVSKP... | 14 |
Q819W7 | 3.4.21.89 | ACT_SITE 39; /evidence="ECO:0000256|PIRSR:PIRSR600223-1"; ACT_SITE 80; /evidence="ECO:0000256|PIRSR:PIRSR600223-1" | MKKEKSSLWEWIKAILIAVVLAGVIRQFFFAPILVDGVSMAPTLHDRDRMIVNKIGYHIGDPKRFDIIVFRATEDKDYIKRIIGLPGDEIEYRNDKLYVNGKAYEEPYLDKQKKQIADGPLTYDFNLEEMTGKKTVPKDQLFVLGDNRRFSKDSRSIGTISMDQVIGKANMLYWPLEDARIVK | 178 |
A0A9R0IGR7 | 3.1.1.11 | ACT_SITE 264; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MKLKSTTLFWLLAFVTALVSIAFTTTFFNSPSSNLSVVIKKATTLDEFLGVVKEIADGLLRRHHHHHHHHHSHHHHHHHHHHHHREMPDMACSESKWGSTLSSSYRVSLTITVDLHGCGNFSSVQKAVDAVPDFSSSFTLIILDSGLYKEKVMINANKTNLIFQGQGYQNTAIAWNDTSNSTGGTANSASVTIFAPGFIAYNISFQNTAPEPSPGDKGGQAVALKISSDKAAFYGCGFYGSQDTLNDDRGRHYFKDCFIQGSIDFIFGEARSLYQNCTINSIAQGNEQGVDGSITAHGRQSEDESTGFSFVNCKIGGIGR... | 125 |
Q9HN88 | 2.7.6.1 | ACT_SITE 185; /evidence="ECO:0000255|HAMAP-Rule:MF_00583" | MLLSGSSSQSLAAALAAATGERLGDVTYDSFPDGEQLVTVPPAVDGERAVIVASTPTSDAHIEVLQLQDAARDAGASEIITVLPYMGYARQDDAFDPGQPVSARAVARAISTGTDRVLTVNPHEDGVLECFDVPAAGVDAAPQLAAPLPADLTDPVFLSPDHGATDLATSVRDAYGTGVTDHFQKVRHSGSDVTVEPSEIQTAGRDVVVTDDIVATGTTMSEAITALDDPARVFVATVHPLLAGSARLKLARAGVEAVYGTDTIECAVSEVSAAPAIADAL | 114 |
A0A8V0ZBR9 | 2.7.7.7 | ACT_SITE 168; /note="Nucleophile; Schiff-base intermediate with DNA; for 5'-dRP lyase activity"; /evidence="ECO:0000256|PIRSR:PIRSR622312-50" | MHRCMRTAGSRPEPLIDHPRRALIQPREHRTSLLAAASPLRRRNGERRPRSLPAAAQQKSDPRLPHCVPQPVAVSARHRRRCCRVIFRCWSLPLPAMSKRKAPQESLNQGITDFLMELANYERNVSRAIHKYNAYRKAASVISRYPSRIRSGAEAKKLDGVGAKIAEKIDEFLSTGKLRKLEKIRQDDTSASINFLTRVTGIGPAAARKFVEEGIKTLEDLRKNEHKLTHHQRIGLKYFEDFEKRIPREEMLQMQEIVLKEVKNVDPNYIATVCGSFRRGAESSGDMDVLLTHPTFTSESSKQSKLLHQVIEQLEKVHFV... | 121 |
B1L6Y5 | 5.3.1.1 | ACT_SITE 93; /note="Electrophile"; /evidence="ECO:0000256|HAMAP-Rule:MF_00147"; ACT_SITE 141; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_00147" | MHIPRLLINFKAYMESSGDRAVEISKSAERIWREMGVLIGVSPNIVDLRLISSSVEIPVFAQHVDPIPAGAYTGHVPPILVKEAGARGSLLNHSEKQIPLRHIAESINMMRDLNLISIVCSPTPSESAAVAALLPDAIAVEPPELIGSGIPVSKAKPEVILNSLRSVKAINSAIPLLCGAGISSGDDVKAALELGSYGVLVASAVTKSPDPQRKIRELAEPIASFTRA | 213 |
W1NDS0 | 2.1.1.33 | ACT_SITE 148; /evidence="ECO:0000256|HAMAP-Rule:MF_03055" | MASSKGLPRKRFYRARAHSNPLSDSHFPIPITPSDFNYSLHFPHFSNVNSNSEGQQKDSPLLVRFADVGCGFGGLLVRLSPLFPTTLMLGMELRDKVTEYVKERISALRDANPGQYGNISVVRTNSMKYLPNYIGKAQLQKLFFLFPDPHFKEKNHRRRVISPHLLAEYAYVLAPGGIIYTLTDVEELGAWMEGCLDAHPLFEPLSEEEVCTDPVAAILDSATEEGQKVARNEGQTFRSVYRRRVLPPTECSSG | 45 |
Q9LM33 | 2.7.11.24 | ACT_SITE 230; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MGGGGNLVDGVRRWLFQRPSSSSSSSSSNNNNNNHEQPIFNSSSFSSSSNPNHSANSGELIIEEDLDFSGLTLINVPKRNHLPMDPHKKGETEFFTEYGEANRYQIQEVVGKGSYGVVASAVDSHTGERVAIKKINDVFEHVSDATRILREIKLLRLLRHPDVVEIKHIMLPPSRREFRDIYVVFELMESDLHQVIKANDDLTPEHYQFFLYQLLRGLKYVHAANVFHRDLKPKNILANADCKLKICDFGLARVSFNDAPTAIFWTDYVATRWYRAPELCGSFFSKYTPAIDIWSVGCIFAEMLLGKPLFPGKNVVHQLD... | 104 |
O23304 | 2.7.11.1 | ACT_SITE 139; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MARNKLEFPLDAEAYEIICKIGVGVSASVYKAICIPMNSMVVAIKAIDLDQSRADFDSLRRETKTMSLLSHPNILNAYCSFTVDRCLWVVMPFMSCGSLHSIVSSSFPSGLPENCISVFLKETLNAISYLHDQGHLHRDIKAGNILVDSDGSVKLADFGVSASIYEPVTSSSGTTSSSLRLTDIAGTPYWMAPEVVHSHTGYGFKADIWSFGITALELAHGRPPLSHLPPLKSLLMKITKRFHFSDYEINTSGSSKKGNKKFSKAFREMVGLCLEQDPTKRPSAEKLLKHPFFKNCKGLDFVVKNVLHSLSNAEQMFMES... | 99 |
B9SEV4 | 3.4.19.9 | ACT_SITE 200; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR615527-1, ECO:0000256|PROSITE-ProRule:PRU00607"; ACT_SITE 313; /evidence="ECO:0000256|PROSITE-ProRule:PRU00607"; ACT_SITE 313; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR615527-1" | MPSHSLSNSSSTPSIRPSSDLSNDAVALPSPPSSSSTPSDMWNYLWIPILISLSKELSLAKASRSNINSNNSNILLPSQLDDEPVPRCLAPDPKLNYRPVIGIVSHPGDGASGRLSNATNASYIAASYVKFVESAGARVIPLIYNEPPDILFEKLNLVNGVLFTGGWAKNGLYYDIVKAIFKKVLDKNDAGYHFPLYAICLGFELLTMIISKDRNILESFNAADQASTLQFMGNINIEGTVFQRFPPGLLKKLSTDCLVMQNHHYGISPERLQENQDLSGFFKILTTSADADNKVYVSTVQALSYPVTAFQWHPEKNAFE... | 176 |
M9PCU5 | 3.1.1.3 | ACT_SITE 214; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR000862-1"; ACT_SITE 388; /note="Charge relay system"; /evidence="ECO:0000256|PIRSR:PIRSR000862-1"; ACT_SITE 419; /note="Charge relay system"; /evidence="ECO:0000256|PIRSR:PIRSR000862-1" | MCINSKNNTHIHPSGVVDCTLIALSLCLLQSGIVEGISLSLGDITLFNVNFKTPTFLGRSVAVDSNVRLENDVDPNIQEDSHLNTYSLIKKYGYPAENHTLETDDGYILTLHRIARPGATPVLLVHGLLDSSATWVMMGPNKGLGYLLYDQGYDVWMANVRGNTYSRKHVKYSTHHAKFWDFTFHEMGKHDIPATMDYILNSTGVSQLHYIGHSQGTVVFWIMASEKPEYMDKIILMQGLAPVAFLKHCRSPVVNFLAEWHLSVSLVLKLIGVHEFLPKNEFISMFNRIICDETTITKEICSNVIFLTTGFDKLQLNETM... | 128 |
D8RDK1 | 3.1.1.11 | ACT_SITE 157; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | VVVDQDGNGDHASVQEAIDAVPVNNTVPITIFVSPGVYQEKVKIVESKPYITLQGSGADLTTIVWDDYAGKLGVDGSHLGTFHTATVHVSAPYFSARGITFKNSAPVQPAGSQAVAFQITGDMAAFYECNFIGAQDTLYDHSGRHYFKSCFIQGSVDFIFGNGRSLYKDCELNAIGSGALTAQKRQNASDNTGFSFVNCRILGNGLVYLGRAWGPFSRVVFLYCYMDSVINPGGWDDWGDSSRDMTVFYGEFNCTGPGANGMRRVPWSYVLTEAEAQPFLDERFIEGDAWLQ | 125 |
A0A072U0A6 | 3.1.1.11 | ACT_SITE 424; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MSSFKAYGKVDESAQAMFEVRRKSRKRITIICLSTVVLIGIVFAAVFGTIAHNNARNDDNNNNENDNNDQSLSSAIKAVCDVTLYKDSCEKSLSPLVQPGQQIRPEELFKLSIQVALTAVSKGVEYLSDHATFNDLNLNLDNRTKEALINCKDLFGLAVDDLNSSLSYGGKSSLLDVLEDLETWLSASGTYQQTCIDGLEQAEEALKSSITTNLKNSTEFTSNSLAIITWLNKAASSVNFRRLLSLSHQNEEPNWLHHKDRKLLQKDSDLKKKADIVVAKDGSGKYKTISAALKHVPNKSDKRTVIYVKKGIYYENVRVE... | 125 |
A0A2I3RN08 | 3.1.3.3 | ACT_SITE 20; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR604469-1"; ACT_SITE 22; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR604469-1" | MISHSELRKLFYSADAVCFDVDSTVISEEGIGELAKICGVEDAVSEMTWRAMGGAVSFKVALTEHLAPIQPSREQVQRLIAEHPPHLTPSISKRSRCSSRLQERNVQVFLISGGFRSIVEHVASKLNIPATNVFASRLKFYFNGKMSGVRDHPGQRGEAPTLLKKKKKKKKIGKLDAFIGFGGNVIRQQVKDNAKWYITDFVELLGEPKE | 147 |
H3G8B9 | 3.2.1.21 | ACT_SITE 168; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR617736-1"; ACT_SITE 381; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR617736-1" | MTKEIRFPDGFLWGAATASYQVEGAVNEGGRGASIWDAFSHTPGKTVNGDTGDVAIDHYHRYKEDVQLMKSMGLKAYRFSIAWPRIIPAGVGQVNEEGVQFYNNLINELLANGIEPMATLYHWDLPLALQTEFDGFLGEQIHDHFAQYARVCFEKFGDRVKNWITMNEPWVANYMGFGTGMLAPGRKHNKHFEPYLAGHNMLLAHARAVEVYRKEFQETQGGQIGITLSAEWKEPGPTDDPEQEKKNIAAAERAMAWSFGWFAEPVYYGDYPQIMKDRCGDRLPKFTEEQKKLLKGSSDFFGLNNYSSNFVKPSPEFEAG... | 161 |
A0A3B6PEM1 | 2.1.1.37 | ACT_SITE 411; /evidence="ECO:0000256|PROSITE-ProRule:PRU01016" | MAPAPAGASPTRKRRSADEPPRVVTERATRGRPPREDGGPELVGDPIPADEARAKFPNRYHHQRRNGEGEEEEVEARCHYRAAKVEGTVYNLGDDAYVVAEEGRPHFIGRITELFEGTDRVKYFNCRWFFRSEDTVISTAELVGDHSHDPKRVFLSDERNDNPLDCIVSKVKVLQVDPKLDLEAKARLAADSDLYYDMSYTVPYSTFENITNDINEMSGISSDADSEADTSVATATLLDLYSGCGGMSTGLCLGAALAGLKLETRWAVDFNSHACKSLKSNHPKTEVRNEKADDFLSLLKEWAVLCDQYVHGNNAEAPPP... | 47 |
A0A078J5S8 | 3.2.1.143 | ACT_SITE 280; /evidence="ECO:0000256|PIRSR:PIRSR607724-1"; ACT_SITE 298; /evidence="ECO:0000256|PIRSR:PIRSR607724-1"; ACT_SITE 299; /evidence="ECO:0000256|PIRSR:PIRSR607724-1" | MSFWKFGKAKRMEKKEYLGSFLKYLPLVAQSSSLAWPPSVEQELQTISEGPTKSMVNSGEVLASHITNMRKSLSLDACDLSPNPLLQGYATFFDKKISREESAKFFGEVVPALCGLLLQLPSMLETHYQNADHVLDGVTSGLRLLAPQEAGVVFLSQELIAALLACSFFCLFPEADRRSKHLQSINFDDLIWFPFMSYCSKRENKIRCLLHYFERVCQCMPTGFVSFERKVLPRGHKHNPHYVSYPDAEYWAKSTTPLCSVEIHTSGAIEDQPGEALEVDFADEYIGGLTLSYDTLQEEIRFVINPELIAGMIFLPRMDV... | 159 |
B7Q2F1 | 3.1.3.16 | ACT_SITE 230; /note="Phosphocysteine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR620405-1" | MFAQSLPVGCKNYLEYCCFGLNSTANKNKIKRLKSLKSATMTTSLARGYGTRTLPPRSRFLGSSTSRTRQADQRRSLNLSCNPSSVYSCDREWRSPKYFSMSMARPAKKLCSIEELIRILVAPSNGYYELPTDPYNEVYPNIFISDGTTALCTGLLRRLGVTHVLNAAMGRDRMYCLINTSPSFYKSSGIEFHGVEALDLSSFKLDRFFQESADFIDKAIASGGKVLVHCKEGISRSATLVLAFLMLKRNLTAQEAVRLVRGRREIIPNQGFLQQLCELNERIHGRGSNEII | 144 |
Q9RD27 | 3.5.1.88 | ACT_SITE 169; /evidence="ECO:0000255|HAMAP-Rule:MF_00163" | MGTPSDRVPLAERVEELLAVGGPLPIVAAGDPVLRRAAEPYDGQVAPALFERFVEALRLTMHAAPGVGLAAPQVGVGLRVAVIEDPAPVPDEVRVARGRVPQPFRVLVNPSYEPAGAGRAAFFEGCLSVPGWQAVVARHAEVRLRAHDEHGRAVDEVFAGWPARIVQHETDHLDGTLYLDRAELRSLASNAAMAELWSQPTPRRAASALGFELPGPAA | 183 |
F5HBY2 | 4.1.1.17 | ACT_SITE 383; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR600183-50" | MAPSAITTTEEYQTLKDSLQSLNSQTLGSVENHGAWKSKQLIGSALKSRVEAIDHDSCDVGDEDAFFIADLGEVYRQHLRWKKNLARVKPHYAVKCNPDTQVLRLMSELGMGFDCASKNEIETVLKLGVDPARIIYAQPCKTKSYVRYAANSGVKQMTFDNADELYKTKQLFPDAELYLRILTDDSGSLCRLSQKFGASLDTTAELLELAHKLELNVVGVAFHVGSGASDPKAFIKAVQDARFVFDQAAAFGFDMHTLDVGGGFTGDITFEPMAAVLSASLDEYFPPHIRVIGEPGRYYVSTAFTIACHVIARRTVADAT... | 195 |
F7CT78 | 3.4.19.12 | ACT_SITE 335; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR016308-1"; ACT_SITE 795; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR016308-1" | MAELSEEALLSVLPTIRVPKAGDRVHKDECAFSFDTPESEGGLYICMNTFLGFGKQYVERHFNKTGQRVYLHLRRTRRLKEEDPATGTGDPPRKKPTRLAIGVEGGFDLSEEKFELDEDVKIVILPDYLEIARDGLGGLPDIVRDRVTSAVEALLSADSASRKQEVQAWDGEVRQVSKHAFSLKQLDNPARIPPCGWKCSKCDMRENLWLNLTDGSILCGRRYFDGSGGNNHAVEHYRETGYPLAVKLGTITPDGADVYSYDEDDMVLDPSLAEHLSHFGIDMLKMQKTDKTMTELEIDMNQRIGEWELIQESGVPLKPL... | 175 |
A0A9J7HD29 | 2.3.2.26 | ACT_SITE 764; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR001569-1, ECO:0000256|PROSITE-ProRule:PRU00104" | MVQTRTIKKTLNPKWNEDFYFRVDPRCRLLFEVFDENRVTRDDFLGLVDLPLNNQIPTEYPDRERPYSHKDYLLRQRRAKNNTKSRVSGHLRLKLAYVPAVGWAEGQQQPNAEQQEDRDEVQIQNPGWEIVDMDTEPRQPQVQGNSPSQPSQPAAMPQGWEERQDANGRTYYVDHNTRQTTWHRPSISHAPGGLTAQAAEAAATTAQESNNRQAAQIFRQRRQISEDMSTPGGAGAAAAAAALVELPAQIASQPRQGPPPPKIHRMSVRSESQPHGQSDRGAEIEALPPGWEMRYTEGGRPFYIDHNTRTTSWHDPRQAA... | 65 |
A7F1Y2 | 2.7.1.11 | ACT_SITE 164; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03184" | MAPQPPPPLEGKKRRIAIMTSGGDSPGMNGVVRACVRMAIYKGCEPYCIYEGYEGLVQGGKLIQKMGWEDVRGWQSEGGTLIGTARCMAFYERPGRLQAAKNMVLNGIDALIICGGDGSLTGADKFRAEWPGLIKELIEKKELSEEQVAPFKHLNIVGLVGSIDNDMSGTDATIGCFSALGKICEMVDYIEQTASSHSRAFVIEVMGRHCGWLALMAGVATGADFVFIPEKPRADNWKEEMCKIIQKHRQLGKRKTIVIVAEGAHDQGGNKISPDMIKDLLADKNGLALDTRISTLGHVQRGGSACAYDRYLSTLQGIEA... | 84 |
B9RSX6 | 1.11.1.7 | ACT_SITE 68; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MMARDGILIAISSLLVLAAVGVSNADGLSLRFYNTSCPDAELIVRNITRNRAQSDSALGAKLLRMHFHDCFVRGCDASILLDAVGIQSEKDTIPNQSLSGFDVIDEIKTQLEQVCPGVVSCADILALASRDAVSLSFQKPLWDVLTGRRDGTVSLASEVNGNIPSPFADFNTLMQQFSNKGLDVNDLVVLSGGHTIGVAHCATFTNRLYNFTGIGDMDPSLDKTYAELLKTKCPNPSNPATTVEMDPQSSLTFDKNYYDILLQNKGLFQSDAALLENTQSARIVRQLKTSNAFFAKFAISMKKMGAIEVLTGNAGQIRQN... | 14 |
Q8DRP3 | 3.5.4.33 | ACT_SITE 59; /note="Proton donor"; /evidence="ECO:0000256|HAMAP-Rule:MF_00972" | MYYTLEEKEVFMREALREAEIALEHDEIPIGCVIVKDGEIIGRGHNAREELQRAVMHAEIMAIEDANLSEESWRLLDCTLFVTIEPCVMCSGAIGLARIPNVVYGAKNQKFGAAGSLYDILTDERLNHRVEVETGILEDECAAIMQDFFRNRRKK | 186 |
W1PTM9 | 2.1.1.37 | ACT_SITE 497; /evidence="ECO:0000256|PROSITE-ProRule:PRU01016" | MAAKKGVKRSRAVYGSSIAPSPCPTPLSEIGASEEEEAFLEDEEMEEMEEMEEMEEMGEMLAKKREPQRRKPTTASTSKASSKKARTSDEVPDSRLLGDPVPVSEAQRRWSHRYNKQKDKRGSTSSNGDNGGETALNVKCHYEQCEVDGCIYILNDSAIVKGEEGGEDYIGKIVELFETTDGQRYFTAQWFFKAQDTVIKEEAADFHDKKRVFYSDMKDDNLLDCIISKLHIVQVAPNVDLVAKAASIPPCDYYYDMSYSIPYSTFSNLKSDNLKFNSDSSTISSEAAVDGAEKSDSDGGCSSESYEKSGFSLLDLYSGC... | 47 |
Q54PX0 | 2.7.11.1 | ACT_SITE 158; /note="Proton acceptor"; /evidence="ECO:0000250|UniProtKB:P28523, ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MIEINNNHNNGNGKQFPSSQIMPDSKKKSIVKIGEYTLGEKIGRGAFGQVFKGLNGKTGEFVAIKQIDSNKIDESSLQSVKGEVEILHKLRHNNIVKVLGVVEVQAQLNFILEYVENGSLRDVIEKFGPLSEELCIIYLYQMLQGLAYLHSNKVIHRDIKASNILITKEGVIKLADFGVASQIDSESQLRFSVVGTPYWMAPESIEISGCSSASDIWSLGSTMIELLTGNPPYYTLQPMAAMFRIVSDQHPPFPTDISKEFLDYFQQSFKKDPTQRPTAQELLQHPIFFTLQKVPPTLSELQSTLKTLNGGRSRLRTSVN... | 99 |
C5X3C5 | 1.11.1.7 | ACT_SITE 110; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MDAKLAALIALLALLGPVACHGATVICLGGWVRPVPSLLGGLVCPGNLLPNPSLNPIPAPSSSVLKVGYYNNSSNSNACPNAEDIVRKVVEDAVSKDPGTGAGLIRLFFHDCFVRGCDASVLLRNTSGGSTSEQTEMFGLPNVNSLRGFEVIDAAKAALESACPGVVSCADTLAFAARDASSVLSGGRISSAFAMPAGRLDGRVSLANETTDNLPGPFCDLDALTNFFAAKGLDRDDMVTLSGAHTIGQARCAFVSNRTDMNATLAKDLRRDKCRSGGNTKVALDYKTPDTMDVQYYQNVNDDDVVLDSDAALSSPATKP... | 14 |
O22040 | 2.7.11.25 | ACT_SITE 197; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MQDFFGSVRRSLVFRPSSDDDNQENQPPFPGVLADKITSCIRKSKIFIKPSFSPPPPANTVDMAPPISWRKGQLIGRGAFGTVYMGMNLDSGELLAVKQVLIAANFASKEKTQAHIQELEEEVKLLKNLSHPNIVRYLGTVREDDTLNILLEFVPGGSISSLLEKFGPFPESVVRTYTRQLLLGLEYLHNHAIMHRDIKGANILVDNKGCIKLADFGASKQVAELATMTGAKSMKGTPYWMAPEVILQTGHSFSADIWSVGCTVIEMVTGKAPWSQQYKEVAAIFFIGTTKSHPPIPDTLSSDAKDFLLKCLQEVPNLRP... | 105 |
A0A2I4EGC8 | 3.2.1.14 | ACT_SITE 94; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001060-1" | MKLFSLILLFSFLLEASAQSGNRTPNPTPSTDGGDVSSIISSSLFDQLLKYKNEFYTYNDFIAATRSFNDFGTTGDVNTRKREIAAFLGQTSHETRGGWPNATDGPYAWGYFFVKENNTTDYCTPSATWPCAPGKQYYGRGPIQLTHNYNYGQAGNATGYDLLNNPDLVATNATISFKTAIWFWMTTQEKKPSSHDVIIGNWTPSAADKSAGRVPGYGVITNIINGGIECGGHAADESVADRIGFYKRYCDAFEVSTGDNLDCYNQSPFT | 158 |
F2Z6G2 | 4.1.1.17 | ACT_SITE 387; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR600183-50" | MAPHILGPEPVQADSSFLGTRPCPTLSYPASFVDEVSASIDQGLSESEKLIANAMKTRIEAIDLETCSPGSEDSFFVADLGIVYSQFMRWSNCLPRVTPFYAMKCNGDPKVLQLLAALGTGFDCASRNEIQTILDLGVSQDRIIYAHPCKVASYIRYASSVGVEKMVFDNAEELYKCAKYHPTAKLFLRIVTDDSQSLCQFSVKYGAALENTQSLLQLAKDLGLNVAGVSFHVGSGAGDPNAFLDAVRNAKRVFDQGAAIGMHLNTLDVGGGFSDDSFESSAAVLGDALDKYFPEESGVNLMAEPGRFFVSEAFTIASHV... | 195 |
W5N1L8 | 3.1.3.48 | ACT_SITE 143; /note="Phosphocysteine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR037322-1" | RWWYVLLNNMRNSEFDSSDEEDAAEEQTPLLISWLPLSVVEWSQFLGICALPGCKYKDVRRNLQKDIGELRGQGVEEVFVFCTRGELQKYRVPQLIEVYKQQGLSVHHRPFPDGGTPELEQCCQILEELQYSLQNNRRVVMHCYGGLGRSGLMAACLLLQLSGSMTPDKAIEILRELRGAGAIQTVKQYNFLHDFRERSAAYQATKEVAAERSVSR | 149 |
H2MK46 | 4.1.1.50 | ACT_SITE 72; /note="Schiff-base intermediate with substrate; via pyruvic acid"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 86; /note="Proton donor; for catalytic activity"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 233; /note="Proton acceptor; for processing activity"; /evidence="ECO:0000256|PIRS... | MMMEDQDNGAHFFEGTEKLLEVWFCRQDDTKGTGDLRSIPRFEWDKLLENVHCLIISVTKTDKQEAYILSESSMFVSKRRFILKTCGTTLLLQALVPLLELAREYCGFDSIENFFYSRKNFMKPAHQEFPHRNFQEEVDFLSQIFPNGAAYCMGRLNSDCWYLFTLDLPEYWENNQADQTLEVLMSDLDPAIMDQFYMKDGVSASDVTRMSGIRDLIPGSVIDATLFNPCGYSMNGMKTDGTYWTIHITPEPEFSYVSFETNLSQTSYDELVRKVVEVFKPGKFVTTLFVNQRSKCRSVFSSNQKLDGYKRLDRQLAQFN... | 196 |
A0E5N5 | 2.3.2.26 | ACT_SITE 871; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MQGIMKTNTIISIKETKKYANILIYKPGPINSDLKSDEVFLFNYPNNHSFNQKIVKLDPEDYVLVNHTNIQQVGSDLMNMWHLEFGSELTIFRQITFDENSKPITNVNLLRQDIYMKIQNSTRGTIQVDEKCLIKQWIMLIKSALKSEFQLNCENIRLWKHKHFPANQAIKQLEQHNGKFHGQILDENQSVGYYKADLIIIDIQLNGKWQFELLDLKTASLEEFKHVFNKAYKGCGKFYCDKNYCNSNPVFNQLQFEKASLQQFLIESFKEDSIDWSEVCWNSDYELKPIQQIEEDIIQQISKVSIYPNSFGGSFVQDFN... | 65 |
I1MVE2 | 3.1.3.48 | ACT_SITE 31; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR628472-1"; ACT_SITE 33; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR628472-1" | MATASGMPEQETQVFSGNNDQYPRLDVYVWDMDETLVLLNSLLKSSYAEAFNGLKDVQKGVEIGRTWENLILQICDDYFFYEQIENYNKPFLDALAQYDDGRDLSDYDFNQDELGSPHEDDANNRKLAYRHRVIAQKYLQGLRNILDHETIKLWDELYDKTDEYTDRWLSSARTFLKECSGEDKDAVSSVAFANTSSNSTNSNHVNVLVTSGSIVPSLVKCMLFHLDSLITHGNVYSSWEVGKIQCFRWIKERFNHPNVRFCAIGDGWEECEAAEIMRWPFVKIDPRPGKLHRFPGLTLTTVSHYFSVVYGRPGNENDEE | 149 |
P44997 | 3.1.3.3 | ACT_SITE 109; /note="Nucleophile"; /evidence="ECO:0000250"; ACT_SITE 111; /note="Proton donor"; /evidence="ECO:0000250" | MQIQCFESITQKYPQFPTALLANEEPIQNGEPFILYGTKLDITKLEKFQQKCGQNFQIFDVWMVAKNIIVLLKGQWFSDFIKFTHDVEVDIAKLDFSPKLSQAGLLVMDMDSTAIQIECIDEIAKLAGVGELVSAITESAMRGELDFEQSLRCRVGTLKGAPESILQQVRENLPLMSGLVETIQTLQKYGWKTAIASGGFTYFADYLKALLQLDFAASNQFDIEDGKLTGLVKGDVVDAQYKAKTLQHLLEEYGIDSRHSIAIGDGANDLAMMNVAGLGVAFHAKPKVQPQAQIVVNFADLTALLCLLSANDRI | 147 |
H0YY17 | 2.7.10.1 | ACT_SITE 662; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR620777-50" | MVSWRRRPGPGLAQLWGLCCLVLGCWPAALGCPASCGCSSWRIWCTGSSPGIASFPVPQRSAEGDNVTEIYIANQPNLESINDNEVGFYVGLKNLTVVDSGLRFVSRHAFVKNVNLQYINLSRNKLSSLSKKPFRHLGLSDLILVDNPFKCSCEIMWIKKFQETKFYTETQDLYCIDDNNKKTALLDMKVPNCDLPSANLSNYNITVVEGKSITLYCDTTGGPPPNVSWVVTNLVSNHESDTNKNPASLTIKNVSSMDSGLEISCVAENIVGEDQASAELTVFFAPNITFIESPTPDHHWCIPFTVKGNPKPTLQWFYEG... | 97 |
P09394 | 3.1.4.46 | ACT_SITE 36; /note="Proton acceptor"; /evidence="ECO:0000250|UniProtKB:Q8RB32"; ACT_SITE 78; /note="Proton donor"; /evidence="ECO:0000250|UniProtKB:Q8RB32" | MKLTLKNLSMAIMMSTIVMGSSAMAADSNEKIVIAHRGASGYLPEHTLPAKAMAYAQGADYLEQDLVMTKDDNLVVLHDHYLDRVTDVADRFPDRARKDGRYYAIDFTLDEIKSLKFTEGFDIENGKKVQTYPGRFPMGKSDFRVHTFEEEIEFVQGLNHSTGKNIGIYPEIKAPWFHHQEGKDIAAKTLEVLKKYGYTGKDDKVYLQCFDADELKRIKNELEPKMGMELNLVQLIAYTDWNETQQKQPDGSWVNYNYDWMFKPGAMKQVAEYADGIGPDYHMLIEETSQPGNIKLTGMVQDAQQNKLVVHPYTVRSDKL... | 156 |
A0A8I6X2M8 | 1.11.1.7 | ACT_SITE 80; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MAALSRAAMVLTMMGLAATSALSQPSLISMTTDVPLPDGLSYDFHALSCNNLQNMVRDAVQGAIARDAGVVPGLLRLFFHDCFPQGCDASILLTGGNSEQNMGQNVGLRRSVLDLIESIRATVHRACGPTVSCADITSLATKEAVMQSRLPGYDVPLGRRDSLTPATAQQVGILPGPDSNVQQLVRTFADRGFDKMDLVALSGAHTVGKASCGSFRSRAGENADFVRMLQQVCARNPRHLQDLDVATPNTFDNRYYNNLQVGRGVLNSDMALTLDGDTKNWVNNFAGNQGWFFSQFSTSMRKLAHLPGGNIGEIRNNCFR... | 14 |
A0A1S3XSQ7 | 1.11.1.7 | ACT_SITE 246; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MAAKARIFAGLFLICTILPSLSSAFADHLPEVLLANNSDKNIDVPIHVNNVAHVSDDDDTIFELDGKKGKKLKRALKKRAQKQHDLWEKILDHDIIEESQPEEDAAPVTPTPVPVNPTPTPVPVDPTPNPVPINPTPNPVTVNPTPTNVPAGYPGATLPPVTIGYGGAPQTPNPSATQTPVPVQPAPGQKHPTPEEIKELRKHARLKVGFYDEICPKAEKIIKDGMIRAFGNDSSIAAAIPRLLLHDCFVNGCDASLLLDQTPSGARVEKLANSNGPTVRGFDLIDQIKAELEAECPRVVSCTDLLVYLSRDAFVVSGVP... | 14 |
I1K8L0 | 1.11.1.7 | ACT_SITE 68; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | METRTGTLSITVCSLVMFSFVSLVKGSLSFNFYAASCPSAESIIRNIVSSSSSTDPTIPGKLLRLVFHDCFVEGCDASLMLQGNNTEQSDPGNRSVGGFTVIDSAKRILEKFCPGTVSCADIIALAARDAVEIAGGPRTMIPTGRRDGMVSVASNVRPNIVDTSFSMDEMVKLFASKGLSLLDLVILSGAHTIGTAHCSSFRDRFQEDSKGKLRLIDKTLNSDYANELIKQCPAGVQPSVTVNNDPETSMAFDNMYYQNLLAHKGLFQSDSVLISNDSTRKLVVDFANDQELFFENWDQSFLKLTSVGVKTGDKGEIRIS... | 14 |
A0A2K3CVA1 | 5.1.3.15 | ACT_SITE 204; /evidence="ECO:0000256|PIRSR:PIRSR016020-1"; ACT_SITE 302; /evidence="ECO:0000256|PIRSR:PIRSR016020-1" | MALRSVAMRGQARPSVSAARRSAVSAHRAVNVVASSVADLNKKHGIPGSVEFKEGKSGSPVVVLKHACGASAEMYLFGACVTSWKQPSGDEVLYVRPDAVFDKSKPISGGVPHCFPQFGPGAMQQHGFARNLDWAVSTTSADPNPDEKDPSVEVVLTESDYTLKMWPHKFKAVYTVSLHGEQLNLQLRVINTDDKPFDFTAALHTYIEVLEIAKAKVTGLKGLTYLCKAVDPKVPETKKEDRDAVTFTGYTDSVYLNSPAHVELEVGTGAAVALDSTGWEDTVVWNPHLTMKDCYQHFCCVENAKFGKAATVKPGESWTA... | 210 |
K3ZUL4 | 1.11.1.7 | ACT_SITE 103; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MRTPPPAISPFLAVSALLLLLFATSVAANGYGGGDGASSGPKGNGEQEGVYHIPAYEKPVKGLDAGFYRKSCPEMEGIVQKAVRKAIRDDYTLAASLIRLFFHDFAVQGVDASVLIDEPKKSEKYAEASRTLRGFDLIEKIKKEMESKCHATVSCADILTAAARDAATAVGVPYWPLRYGRRDGKNSIAAEADLHVPMGGKSVTDLVRFFESKGLTIFDLVVLSGAHTIGRATCGAVKPGLCKRKDKPALLDRRYGDFLRRKCGAGGDGEYVELDGETPTAFDNQYYKNLMHGRGVLDTDQKLLLDSRTGDHVRAFANQP... | 14 |
Q8A6N4 | 6.3.4.4 | ACT_SITE 13; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00011"; ACT_SITE 41; /note="Proton donor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00011" | MKVDVLLGLQWGDEGKGKVVDVLTPKYDVVARFQGGPNAGHTLEFEGQKYVLRSIPSGIFQGDKVNIIGNGVVLDPALFKAEAEALEASGHPLKERLHISKKAHLILPTHRILDAAYEAAKGDAKVGTTGKGIGPTYTDKVSRNGVRVGDILHNFEQKYGAAKARHEQILKSLNYEYDLTELEKAWMEGIEYLKQFHFVDSEHEVNNYLKDGKSVLCEGAQGTMLDIDFGSYPFVTSSNTVCAGACTGLGVAPNRIGEVFGIFKAYCTRVGAGPFPTELFDETGDKMCTLGHEFGSVTGRKRRCGWIDLVALKYSVMING... | 253 |
Q9USJ4 | 3.1.1.5 | ACT_SITE 1044; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"; ACT_SITE 1163; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01161" | MDITDRILQNRIVSKVIFFVLRSVTLSLVSVTRFSLFLLSFATITVPKWAYKIVTYSLTIQFNFKSLLFLFFVSICVVILVVRYRYLNKYARLPHEAPIKEAKLGPDTNIRPSEPRIGFQNYLDEFLSAISIFGYLEKPVFVELARHIRTQRVAEGNTIYLGEQSSFILVVDGCFQVFTAPEKDSAEVVEEAGQPEYRLLTEVSNGAPLSSFFTVLELFTELIPEATSKENPFKSTTSSLRPGSSTTTEAGANNASKPHMPQPKKARIIAKAKIDTTIAVIPANAFHHLVHKFPNSSAQIVQVILTRFQRVTFSTGYEYL... | 131 |
D6W9J7 | 2.3.1.286 | ACT_SITE 133; /note="Proton acceptor"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00236" | MSCNYADGLSPYEHKGVLGAPERFDPPERVQEKCEMLADWIRNARHVVLHTGAGISTSAGIPDFRGPNGVWTLEKQGKKPNIDISFKDAIPTKTHMAIKKLVEENYVHYIISQNIDGLHLRSGITRKYIAELHGNMFVEQCNFCDSQFVRNLPTATVGKKCLEINCKRILRGRPCRGKLCDTILDWEHNLPEKDLEMSDYHSSVADLNICLGTTLQIVPSGNLPLRCKKFGGKVVIINLQPTKHDKKADLIINTYVDDVLEKVMKRLGLEIVEYCEKGDPTMNPLEGLNWNITKCNIKEVKALYDLYCKKTKKRKLEMKK... | 58 |
A0A1L8G4Y4 | 2.7.10.1 | ACT_SITE 789; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000666-1" | MSFWWIYLALLTLAFSHNTQALRTYPSNEVLTSDALHPCVQSSCSVTLLDSMSAIGDLGWVAYPPDGWEEISVMDERNTPMRTYQVCNVLEVSQNNWLRTSWIPRGNAQRVYIEIKFTLRDCNSLPGVSGTCKETFNMYYYESNNSNLKFIKENQYVKIDTIAADESFTQVDVGDRVMKLNTEVRDISNLYKKGFYLAFQDVGACIALVSVRVFYKKCPMTIRNLALFPDTVTGGDSALVEVKGSCVNNSVEFDVPKMYCSADGGWLVPIGRCACKPGYEEKREACIPCRPGFYKALLTDTYCTKCPPRSSSLQDSAAEC... | 97 |
Q0UQJ0 | 1.1.1.37 | ACT_SITE 200; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000102-1" | MFAARQAFSQASRRAFSSSARQSSKVTVLGAAGGIGQPLSLLLKLNPRVTKLSLYDIRLAPGVAADIGHINTKSEVTGHEATPSGLADALKGAEIVVIPAGVPRKPGMTRDDLFNTNASIVRDLAKAAAEHAPEANILIISNPVNSTVPITAEIFKSKGVYNPKRLFGVTTLDVVRASRFISQLKNTDPSSENITVVGGHSGATIVPLLSQSGYNLEGEKLDSYVNRVQFGGDEVVKAKDGAGSATLSMAMAGARFAESLLKAAQGQKNVIEPTFVDSPLYKDQGCEYFASNVELGPNGVEKIHPVGKITDYEQKLLDAC... | 5 |
A0A1S3ZRV9 | 3.2.1.14 | ACT_SITE 74; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001060-1" | PPPTPSQDITEIISSNLFDELLLHRNNVACPARGFYTYDAFVQAARNFIGFGTTGNTTDRKREVAAFLAQTSHETTGGWDTAPDGPYAWGYCFKAEVGNPDDMPSYCEPNVEWPCAPGKKYYGRGPIQISYNYNYGPCGVAIGENLLGDPDLVAANTVISFETALWFWMTPQPPKPSSHDVILGIWEPTPSDIAANRLPGYGVITNIINGGLECGHGPDKRVQSRIGFYLRYCQILDVSPGENLDCSDQRSFADGLLFNSM | 158 |
A0A8U0WPL4 | 1.1.1.37 | ACT_SITE 193; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000102-1" | MQQPIPWEKVNRTEPLHVLITGAAGQIGYNLCFLIGRGFLFDCDVILHLYDLNDMALKGLSMELTDCCLPKLKGIISTTEIALAFSNVDVAIIVAGVPRKPGMQRSDLINVNKKVMEMNGKALGTYSNKDVRVVVVANPANTNAYVICKTSGIPPEHITALTRLDQNRATAFVANEVGCQPEFVHNIIVWGNHSNTMQPDLSYSYLADQNGIKPLANCIEDFDAFTEKVRCRGEEVISTRKASSAGSAAHAICQHIKDWIYGTKPGIMVSMGVSSNGEYGIDTGLFYSMPVTCSEGEYHIVDSLVIEPRIKDSLILSELE... | 5 |
Q7S8J1 | 3.1.1.5 | ACT_SITE 1245; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"; ACT_SITE 1363; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01161" | MESLSNLGNAMSSVLSETTSTTATAILADPTEALSSVVALASDAVSKATSDVVPEHTPTSWFTIILWLLHRISSVLYFVIKLTTITTPTFLFNIFSTSLTVTMNATTLVLIMLFMMAGVTWVVRYRYLNMYSRLPPEPQRKEPAVDLFPETQEEGVKSGLASYFDEFLSAIKIFGYLERPVFHELTRSMQTRKLIAGETLNLEEEQGFCLVVDGMVEIFVKSARDGRRSSSGPSFESDDEEGFAPGRQRYQLLTEVRNGAPMSSLFSIMSLFTEDIQMHDTDDDDSPDPTPSAPGTAMPGYPMNANFQQSNDTLPSIPGT... | 131 |
Q5A6T5 | 2.7.12.2 | ACT_SITE 374; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MTRTTRIDTQEATKHKDLPPVPSPLSLSSNPNPECLMESKSLGRKNFKKLSLDASPVKSTSGSLRSSDMMSIKEPTSLRQKRQRPPPILHLPTASSSATSTPTSNITGSSSASSIQFAQKSPGSGVIVSQTLSRPSSAGGIPSSGYSSLNVNQSNRNVDPDNVVSTDMILNQISNLDLTSMNHHRQHYQNSHHHLPTTNRKRQTVISSISPTKSSAASSSLEPQIQSLPASSQSPIATTSSLKLNNKDLLTLKQLGSGNSGSVSKILHIPTQKTMAKKIIHIDSKSVIQTQIIRELRILHECHSPYIIEFYGACLNNNNT... | 108 |
A0A9J7KG07 | 3.1.3.16 | ACT_SITE 152; /note="Phosphocysteine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR620405-1" | MGQVATKVLKPFLPTGCFLGMEEDYEDSIPKTFSVSQMKDVLFAYSHGQYVVPSRHYNEVYKNIFVGDESSARNKHRLMGLGVTHVLNAAEGKSPFMHVQTGPEFYEDVGIDYYGVRASDFEQYNLMQHFEDAAKYIHKAVDEEGGKILVHCREGYSRSPSLVMAYLMIYKEHNVEDALIAVRQKREIGPNTGFLKQLCLFNDKLEAEKQRRMAEEYQAEMEGRNEKGEEESRKEDKTEDSKPEETQDENKEKSKTEANEESRENVQEKDEHVLVS | 144 |
Q9X8I9 | 3.6.1.1 | ACT_SITE 89; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00209" | MEFDVTIEIPKGSRNKYEVDHETGRIRLDRRLFTSTAYPTDYGFVENTLGEDGDPLDALVILDEPTFPGCLIRCRAIGMFRMTDEAGGDDKLLCVPSTDPRVEHLRDIHHVSEFDRLEIQHFFEVYKDLEPGKSVEGADWVGRTEAEAEIERSYKRFKDQGGH | 188 |
A0A2C9VBM5 | 3.1.1.11 | ACT_SITE 387; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MASKFSAIPLLLILFFSLSHARFSPIFTSPETLCNSTPHPSFCKSSLPYNNPGTIHDYAKVSISQSLTNARNFLSLVQYYLTLPSTSYESTIRALEDCQFLAQLNIDSLSYAFETIDNSYDLPGSHSDDLLTLLSATLTNVETCLDGLQSTASASSILKAFSAPLSNGTQCYSVSLSLFRGGWVPKTAEGRLLTERKSINFPNFEKGARKFLPLQSTNGRKLLERFTDGVSVSKMVVVNPYGNGDFATITDAVNSAPNNTGSGDGYFVIYVVAGVYNEYVSIPKNKKYLMMIGDGINQTIITGNRSVVDGWTTFNSSTFA... | 125 |
Q8A8S8 | 2.3.1.181 | ACT_SITE 183; /note="Acyl-thioester intermediate"; /evidence="ECO:0000255|HAMAP-Rule:MF_00013" | MKTVLVDWNLIPYAEAWQRQTEWFDTLVRAKAQGEAYENRIIMCEHPHVYTLGRSGKENNMLLNDDQLKAIQATLFHIDRGGDITYHGPGQLVCYPILNLEEFHLGLKEYVHLLEEAVIRVCASYGIEAGRLEKATGVWLEGSTPRARKICAIGVRSSHYVTMHGLALNVNTDLRYFSYIHPCGFIDKGVTSLRQELKHEVPMDEVKQRLECELGRLLNEKKQQIAQ | 55 |
K4A924 | 6.3.4.4 | ACT_SITE 79; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03125"; ACT_SITE 107; /note="Proton donor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03125"; ACT_SITE 207; /evidence="ECO:0000256|PROSITE-ProRule:PRU10134" | MSLSTLSHPAAAAAAAAGSGKSLSPAFPAAQSARLPKTRPHAPAAVSAAAAAAVHADSAEDRVSALSQVSGVLGSQWGDEGKGKLVDVLAPRFDIVARCQGGANAGHTIYNAEGKKFALHLVPSGILHEGTLCVVGNGAVIHVPGFFGEIDGLESNGVRCDGRILVSDRAHLLFDLHQVVDGLREAELENSFIGTTKRGIGPCYSSKVTRNGLRVCDLRHMDTFGDKLDVLFKDAASRFQGFEYSKSMLKEEVERYKRFAERLEPFIADTVHVLNESIQQKKKILVEGGQATMLDIDFGTYPFVTSSSPSAGGICTGLGI... | 253 |
Q9WXZ5 | 2.6.1.16 | ACT_SITE 2; /note="Nucleophile; for GATase activity"; /evidence="ECO:0000255|HAMAP-Rule:MF_00164"; ACT_SITE 601; /note="For Fru-6P isomerization activity"; /evidence="ECO:0000255|HAMAP-Rule:MF_00164" | MCGIVGMVGENLKLEDLVTSLQKLEYRGYDSAGIAYLGDSFGVYKKKGRIDVLKNGLKQKLNDRFFVGIAHTRWATHGEPNDMNAHPHMDCKEEIAVVHNGIIENYREIREFLEQRGHVFSSETDTEVIAHLVEEEFEGDLLDAVLKAVKKLKGAYAIAVVHKNVPDTIVAARKGSPLVAGIGSGVGILASDVTPLLRFTKDVVFLEDGDVMVLRKDGFEIYNTDGVKQQRRVYHVNWDEKAAEKGGYKHFMYKEIMEDPQALVNALVGRVKNDRPFFEELEYYEELLKNADRIRVVSCGTSYYAGLVFKYFLENHTDID... | 81 |
A0A9R1XII7 | 2.1.1.37 | ACT_SITE 480; /evidence="ECO:0000256|PROSITE-ProRule:PRU01016" | MPRAKRRSSSASKDDALVSSEKRPKIEEKKEEDEEVSVVPDLVSPAKSSGGKSEKPKVRSKAKEKVKDEVEDAEESRFVGDPVPAEEARQRWPLRYLQKNKAGKTESLETPKGVEPPKELMQAKRHFTEALVDGRVLFKLGDDGYVQAGEGEDSYICRVVEMFEGVDGTSYFSAQWFYRAKDTIIQACSNLIDDKRVFLSEIRDDNPLDCLLQKLQIVRVPLDADVSEKQAKLGDGDYYYDMSYLVPYSTYQNLPPDAEADGNESDSTISSESDVNGAVNEESQSQNNKRSEMRMLDLYSGCGAMSTGLCLGANMADVNL... | 47 |
B8E0W1 | 4.2.1.11 | ACT_SITE 204; /note="Proton donor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00318"; ACT_SITE 336; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00318" | MPAILDVHGREVLDSRGNPTVEAEVYLEDGSVGRAIVPSGASTGSREALELRDNDPKRYKGKGVLQAVKNINEIIAQELIGLEALNQYTVDKTMLELDGTENKSRLGANAILAVSLATARAAAASLGVPLYVYLGGVQARELPTPLMNVINGGKHADNPLDFQEYMIVPLASTFKESLRWAVEVFHTLRSILKSKGLNTNVGDEGGFAPYLEKNEDPLAILVEAIQKAGFEPGKDVALALDLAASEFYEDGKYILKAEGKELTSDEMISLLEYLCDKYPIVSIEDGLSEKDWDGWKKLTDKLGKRVQLVGDDIFVTNPQI... | 200 |
Q3U4H6 | 3.2.1.52 | ACT_SITE 149; /note="Proton donor"; /evidence="ECO:0000250" | MSSPTPFKMRLVHLDLKGAPPKVSYLSEVFPLFHALGANGLLIEYEDMFPYEGHLRLLRAKHAYSPSEVTEILRLARLSELEVIPLVQTFGHMEFVLKHAAFAHLREVALFPNTLNPHEAESLALVQAMIDQILELHRDVRWLHIGCDEVYYLGEGETSKQWLQQEQNSHAKLCLSHMQAVASHVLTQHPGVTPLVWDDMLRDIPQEQLKASGVPQLVEPVLWDYGADLDVHGKVFLIGKYQECGFQRLWAASAFKGATGASQALPPVEHHIRNHELWLQVAGSGPKDALQGIILTGWQRYDHFSVLCELLPVGIPSLAA... | 170 |
Q83EK2 | 2.7.7.7 | ACT_SITE 157; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR606309-1" | MGNLMRQIVLDTETTGLVPEEGHRIIEIGALEMVNRRLTGNHLHFYINPERSIERDAIEIHGITDSFLIDKPLFKDIATELISFLKGAELIIHNAPFDVGFLNHELKLTGQSFKTLTHYCQVLDTLTIARQKHPGQHNNLDALCRRYHVDNSNRDYHGALLDAELLAQVYLLMTGGQTVLFEQQGFAVASRSVSVRPLGTDRDSLSVIRANAAETEAHRAFLQLLTENGLCLWNDQ | 121 |
A0A8R1Z3M1 | 3.5.1.98 | ACT_SITE 150; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR037913-1" | MSATGAALTQVTQEQSRRRVAYYYDSNIGNYYYGQGHVMKPHRIRMTHHLLLNYGIYRDLEVYRPFPASFDEMTRFHSEEYMTFLKTATPDNLKLYNKQMLKFNVGEDCPLFDGLYEFCQLSSGGSLAAAVKLNKQKADIAINWMGGLHHAKKSEASGFCYTNDIVLGILELLKYHKRVLYVDIDVHHGDGVEEAFYTTDRVMTVSFHKYGEFFPGTGDLKDVGAGKGRYYSLNVPLRDGVTDESYQSIFKPVMTRVMDRFQPSAVVLQCGADSLNGDRLGPFNLTLRGHGECVKFFRSYNIPLMMVGGGGYTPRNVARC... | 184 |
Q9HR24 | 3.5.4.5 | ACT_SITE 55; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR606262-1" | MDTDDLLAAARDATAAAHVPYSEYKVGAALDTASGAVYTGCNIENANYSNSLHAEEVAVGKAVSAGDTDFQRLAVTSSQRDAVTPCGMCRQTLAEFAADDLTILCDSGDDTAGVVTYTLGELLPDTITASNLDA | 187 |
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