Datasets:
mrlom
/
ec-active

Dataset card Data Studio Files
xet
Community
1
Entry
stringlengths
6
10
EC number
stringclasses
260 values
Active site
stringlengths
0
544
Sequence
stringlengths
20
2.05k
labels
int16
1
260
A0CN86
3.2.1.52
ACT_SITE 309; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001093-1"
MIFVQLFFLAVNAIMPMPNSIIQGYQTARISSICQVKFFSNQEFPDHVIQLLLHYHELITQDEDCEFEESIQNTNIKIEGALKFEISIENYEQLYWVTSTKEEAYELQIDENLNVKIQAKNHWGLARALDTVNQLAINNEIQNLPIQISDEPQYVHRGIMIDTARNYLPVKLIKRTIDALVINKLNVLHWHITDDESFPLLLSKYSQITNNSKFWKDGFFTKKDVQEIIEYASIRAVQIIPEIDTPAHVHSWGISPDLQSIVITCDTNIRQYGQLDPTLDQTYEVLTSILQDLNDMFDKVQFIHFGGDEASNQCFEQKPSIKEFMNQHGISNYFDLQVYYRKKQKDIWKNQIKSKKKIIYWYNKNDQLPADQDDIIQWWGLSSQLSEVKGRSNQFILSDYHPLYLDTGVGNAFGDRYDRYQAWKDVYKWRPSIPRNFEGTILGGESLLWGETNNQNTHFQKLFLRSSILADTLWNPDQKQDELFPKFTKRLSDMEDRMNKYGFPVSPFTHSYCKRQLDLCFPELYSTKLKLFFMFVLFYSI
170
Q9C7S5
2.7.11.1
ACT_SITE 929; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MIDEKMRSKSIGPFVRQVKPLSPHMVLFVLLYVLSISVFFLTVSEAVCNLQDRDSLLWFSGNVSSPVSPLHWNSSIDCCSWEGISCDKSPENRVTSIILSSRGLSGNLPSSVLDLQRLSRLDLSHNRLSGPLPPGFLSALDQLLVLDLSYNSFKGELPLQQSFGNGSNGIFPIQTVDLSSNLLEGEILSSSVFLQGAFNLTSFNVSNNSFTGSIPSFMCTASPQLTKLDFSYNDFSGDLSQELSRCSRLSVLRAGFNNLSGEIPKEIYNLPELEQLFLPVNRLSGKIDNGITRLTKLTLLELYSNHIEGEIPKDIGKLSKLSSLQLHVNNLMGSIPVSLANCTKLVKLNLRVNQLGGTLSAIDFSRFQSLSILDLGNNSFTGEFPSTVYSCKMMTAMRFAGNKLTGQISPQVLELESLSFFTFSDNKMTNLTGALSILQGCKKLSTLIMAKNFYDETVPSNKDFLRSDGFPSLQIFGIGACRLTGEIPAWLIKLQRVEVMDLSMNRFVGTIPGWLGTLPDLFYLDLSDNFLTGELPKELFQLRALMSQKAYDATERNYLELPVFVNPNNVTTNQQYNQLSSLPPTIYIKRNNLTGTIPVEVGQLKVLHILELLGNNFSGSIPDELSNLTNLERLDLSNNNLSGRIPWSLTGLHFLSYFNVANNTLSGPIPTGTQFDTFPKANFEGNPLLCGGVLLTSCDPTQHSTTKMGKGKVNRTLVLGLVLGLFFGVSLILVLLALLVLSKRRVNPGDSENAELEINSNGSYSEVPPGSDKDISLVLLFGNSRYEVKDLTIFELLKATDNFSQANIIGCGGFGLVYKATLDNGTKLAVKKLTGDYGMMEKEFKAEVEVLSRAKHENLVALQGYCVHDSARILIYSFMENGSLDYWLHENPEGPAQLDWPKRLNIMRGASSGLAYMHQICEPHIVHRDIKSSNILLDGNFKAYVADFGLSRLILPYRTHVTTELVGTLGYIPPEYGQAWVATLRGDVYSFGVVMLELLTGKRPMEVFRPKMSRELVAWVHTMKRDGKPEEVFDTLLRESGNEEAMLRVLDIACMCVNQNPMKRPNIQQVVDWLKNIEAEKNQNNREEPEEEEET
99
F0ZUU2
2.3.2.26
ACT_SITE 1434; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
MRNLSGALLDELQTPLRGGNPAAVGLLNTLIEGRNRSKLLLQGLKSDDENKQMESLLEVCDLLSIATEETIAGFPSDSFAPALINLLNMDHNPDMMLLAGRALSNMIEALPSSISSVVNHGAVSILCSKLLSIEYIDLAEQCLQTLEKISQEQPTVVLRAGGLMATLSFIDFFSTGVQRMAITTASNICRQVPKDCFDMVREPIQILTNLLQYQDQKVVELSCLCFSRLIESFYDSPQKLEIIASHGLISNLVRIISGMYNSTTSLSPNTYSQIIRIMATVCHGCPNITQTLLEEGIISIIQSIMYPSNDNANGSNSNVNRNSQQCYEVLSLINELLPPLPQEFANLLTPNRSIPNSLQSPELLKTLGEDLFVVLVEMFTSNVNTSVRYKSLGCICKVLYYSSSEQIKDLLKEFAFSSFLASLLGSRDMIIVATAIKIVELMMERLPVIFDRYFKREGVVYEVDRLSKLEQPSPPQIPSSLSTSSSLPSTPSSASTATSTTTTIIPTTQEELKSFVCKEAKKLKDTYFPKLQTMMGATNENFSTKELSILKNLSQKLNKCEKEEGVEILEEIKSLLIDTEGISAFEFLHSDLVGSILNYLTRGNIKKHAECFAKVFLVPYQKSGASSMTPLKTSSPNPLLLSLLIEKLHDALNKVERFNINISDVSGTSSGLKYLTQPFKLKLQKEGTDPNLKDYSGNIVLIEPLANITAIEEFLNSKVIVTPNLASAVPASLSCTTTTVGLTTTTSNTNKDGTTEKPVEKEKDSIMDEDDEDEEDTPPTANTSPTASTSTTATGSTTKTPSKLGIFVDGQRLTNSITIFQAVQRIARVQQIATLNSNNNNNNNNDYESSLNVQTNRLWDSTHPPIRELGSSKLIDFLTDDHSFQLTSNDTATYEILSLLRCLYMFNLDPASVNAGSILSNSSMILSSASLFTSERSLLNASEFISQKLTAKIMRQLQDPLALCGGVFPDWCKQLLNSCSFLFPFDCKRLFFYSTSFGIARALSTLQQRQDLIRQTNGSAVSSNNDRGGDFRVGRIQRQKVRIYRNKILESAIKVMDLYGKSKSMLEVEYFGEAGTGLGPTLEFFTLVSKEIQRKDLNLWYTDNTTTTTTTIISEPEKMEIDSLSSPSSSKTPTTPTTTEIIHEYIYCPGGLFPRPINPSTTIDKKLLDYFKFLGSFIAKTFFDQRLIDLPLSKPFYKYMIEQELEFEDLRQLSPAYASSLNNLYSLVLRIKEIKSKSDLSDTQKKEEIDQLRIEGAKIEDLCLDFTLPGFQGWELKEGGENIPVTLENLEEYLNLIVKNFLYDGVIRQFNSFKEGFNQTFSISSLKPFTIAEVESLLCGSLTGSDSDWSIESLMESTKADHGYTLQSKSVQNIFQIMSEFTPEQRKQFLLFISGSPHLPLQGFKGLIPRLTIVKKHHFPPLTPDDYLLSVMSCTNYIKLPDYSNKEVMKEKLLYAMNEGQSSFHLS
65
Q8C0V0
2.7.11.1
ACT_SITE 586; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MSVQSSSGSLEGPPSWSRLSTSPTPGSAAAARSLLNHTPPSGRPREGAMDELHSLDPRRQELLEARFTGVATGSTGSTGSCSVGAKASTNNESSNHSFGSLGSLSDKESETPEKKQSESSRGRKRKAESQNESSQGKSIGGRGHKISDYFEYQGGNGSSPVRGIPPAIRSPQNSHSHSTPSSSVRPNSPSPTALAFGDHPVVQPKQLSFKITQTDLTMLKLAALESTKNQDLEKKEGRIDDLLRANCDLRRQIDDQQKLLEKYKERLNKCISMSKKLLIEKSTQEKLSSREKSMQDRLRLGHFTTVRHGASFTEQWTDGFAFQNLVKQQEWVNQQREDIERQRKLLGKRKPPTANNSQAPATNSEAKQRKTKAVNGAENDPFVRPNLPQLLTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRINNEDNSQFKDHPTLNERYLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATEVQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYLLPHMRRSNSSGNLHMSGLTATPTPPSSSIITY
99
Q9LZV4
2.7.11.1
ACT_SITE 308; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MASLLSPATPTATSAAFHSCSTAGFSTPTHISSQNSSLSLLSRRGCMMRCSFSPQDIPVDSLSHLPPFLDFQNSLATFSDTQKWGFFVSAGIVWFYLTARPGVLIGAIDAYLLAPLQLGLDTLIGRRLKRSDFLVTEKLGEGSFGVVYAGVLLPKNSTLVDDVRVSKARAKAMDFTGEFKQRVILKKVKVGVRGAEEFGEYEEWFNYRLSRAAPDTCAEFLGSFVADKTNTMFTKGGKWLVWRFEGDRDLADYMKDRSFPSNLESIMFGRVLQGVESVKRRALIIKQIMRQIITSLRKIHGTGIVHRDVKPANLVVTKKGQIKLIDFGAAADLRIGKNYIPERTLLDPDYCPPELYVLPEETPSPPPEPIAALLSPILWQLNSPDLFDMYSAGIVLLQMAVPTLRSTAGLKNFNLEIKSVEYDLNRWRERTRTRPDLSILDLDSGRGWDLVTKLISERGSLRRGRLSAAAALRHPYFLLGGDQAAAVLSKLSFSK
99
B9RZW1
2.3.2.26
ACT_SITE 1002; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
MFFSGDPTTRKRVDLGGRSSKERDRQKLLEQTRLERNRRLWLRQQNASAIKIQKCFRGRKAVEIERSKVRDQFYQTYGKHCQNVDWHCFGPDSEFLRQLFFFFNAQNSGDFAVLVETCQRLLQFVRDGGDIISLFGGIDYSTNRALVDYRVKQLSFCCIQAVYQNREQLKNQLLMTLWESSEPVAVLLEVVVLLIDQKLPWACKIVGYLFQRNAFNLCREIVLVAKENMKACNFTGKLSSLERMLSLIISHIGQKPCICPHIDPQCSFISQILTIPFLWRLFPSLKEVFATRGLSEHYIHQMALCVGGNANVLPNDVSVEYPGYACLLGNMLETAGVSLSQPECSFDMAINFAAVATFLLETLPPIVSSSRESKESSALDEDDGIPDDMEIVMNRDLEQQITNAIDSRFLLQLTNVLFGGLSVLSGSEYGLEEKEIMAVGAACAFLHVTFNTLPLERIMTVLAYRTDLVRVLWNFMKQCHEKQKWSSLPEQLSHLPADAPGWLLPLVVFCPVYKHMLTIVDNEEFYEQEKPLSLKDIRCLIVILRQALWQLLWVNMNPTAHNSAVKPITNIPAYKRNPVESVKQRVSVVASELLSQLQDWNNRRQFTPPSDFHADGVDDFFISQAVIEGTKANDIMKRAPFLVPFTSRVKIFNSQLLAARQRHGSNSVFTRNRFRIRRDRILEDAYNQMSTLSEEDLRGLIRVTFVNEFGVEEAGIDGGGIFKDFMENITRAAFDVQYGLFKETADHLLYPNPGSGMIHEQHLQFFHFLGTLLAKAMFEGILVDIPFATFFLSKLKQKFNYLNDLPSLDPELYRHLIFLKHYQGDISNLELYFVIVNNEYGEQTEEELLPGGRNLRVSNENVITFIHLVSNHRLNFQIRQQSSHFLRGFQQLIQKDWIDMFNEHELQLLISGSLESLDVDDLRHHTHYAGGYHSEHYVIEIFWEVLKSFSLENQKKFLKFVTGCSRGPLLGFKYLEPLFCIQRAAGSASEEALDRLPTSATCMNLLKLPPYRRLCLDITKWGKNQSSYLVMAIIIPVLMSFYDCQVLCRRRDLWKPRVKADQNQVLL
65
P00634
3.1.3.1
ACT_SITE 124; /note="Phosphoserine intermediate"
MKQSTIALALLPLLFTPVTKARTPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
141
P16911
2.7.11.1
ACT_SITE 168; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MSQHTSQYVFNSKEDYNVILDNMSREFEERWNHQTQSPYTNLENYITRAVLGNGSFGTVMLVREKSGKNYYAAKMMSKEDLVRLKQVAHVHNEKHVLNAARFPFLIYLVDSTKCFDYLYLILPLVNGGELFSYHRRVRKFNEKHARFYAAQVALALEYMHKMHLMYRDLKPENILLDQRGYIKITDFGFTKRVDGRTSTLCGTPEYLAPEIVQLRPYNKSVDWWAFGILVYEFVAGRSPFAIHNRDVILMYSKICICDYKMPSYFTSQLRSLVESLMQVDTSKRLGNSNDGSSDVKSHPWFQGVDWFGILNQEVTAPYQPTISGAEDLSNFENFEFKDRYKSRINRHPELFANF
99
A6KQT9
3.4.21.92
ACT_SITE 210; /evidence="ECO:0000256|PROSITE-ProRule:PRU10085"; ACT_SITE 235; /evidence="ECO:0000256|PROSITE-ProRule:PRU10086"
MGQRRGFSLFIRTPINEDPTHRLTPPSSAPPISFSEVDEPAAPAKHAGCCSSGNQAWMHGGMWPRVLLRDGRAAAGGCRALLSRFAVRFSPPWSTGSDSPLRSNLHGTATRAFPLIPIVVEQTGRGERAYDIYSRLLRERIVCVMGPIDDSVASLVIAQLLFLQSESNKKPIHMYINSPGGVVTAGLAIYDTMQYILNPICTWCVGQAASMGSLLLAAGSPGMRHSLPNSRIMIHQPSGGARGQATDIAIQAEEIMKLKRQLYNIYAKHTKQSLQVIESAMERDRYMSPMEAQEFGILDKVLVHPPQDGEDEPELVQKETTTAPADPPAPAGT
179
Q8PBR6
6.3.4.4
ACT_SITE 14; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00011"; ACT_SITE 42; /note="Proton donor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00011"
MGQSVVVLGAQWGDEGKGKIVDLLTEEIGAVVRFQGGHNAGHTLVINGKKTVLHLIPSGILRDDALCLIGNGVVISPAALIKEIGELESAGVEVRSRLKISPAAPLIMPYHIALDQAREKAAGGKAIGTTGRGIGPAYEDKVARRGIRIADLHYPAQLEELLRTALDYHNFVLTKYLGVEAVDFQKTFDEALAFGEYVQPMKSDVAGILHDLRKQGKRVLFEGAQGALLDIDHGTYPYVTSSNTTVGGALAGTGVGADAIDYVLGIAKAYATRVGGGPFPTELDDEVGQGIRDRGAEYGASTGRPRRCGWMDIVALKRAVAINGISGLCITKLDVLDGMEKLKVCIAYEYRGKRTEYAPLDAQGWEECTPVYLEFPGWTENTHGITEWDKLPVAARAYLRALEELAGCPISIVSTGPDRDHTMVLQDPFA
253
P35832
3.1.3.48
ACT_SITE 682; /note="Phosphocysteine intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00160, ECO:0000255|PROSITE-ProRule:PRU10044"
MPRPQHHALLRAMLKLLLFASIAEHCATALPTNSSNSPSSPSPFTVASLPPTTASSSSSPAVISTSSFDRNLADLVNPEAETSGSGWESLETEFNLATTVDSSTQKTAKEPVLGTAATSIEQQDQPPDVPATTLAFANAFPVPVAGEMGNGNGNYNDATPPYAAVDDNYVPSKPQNLTILDVSANSITMSWHPPKNQNGAIAGYHVFHIHDNQTGVEIVKNSRNSVETLIHFELQNLRPYTDYRVIVKAFTTKNEGEPSDQIAQRTDVGGPSAPAIVNLTCHSQESITIRWRRPYEFYNTIDFYIIKTRLAGQDTHRDIRINASAKELETAMILQNLTTNSYYEVKVAAATFSVINPKKIVLGKFSESRIIQLQPNCEKLQPLLRQSHNDYNLAVLVGIIFSCFGIILIIMAFFLWSRKCFHAAYYYLDDPPHHPNAPQVDWEVPVKIGDEIRAAVPVNEFAKHVASLHADGDIGFSREYEAIQNECISDDLPCEHSQHPENKRKNRYLNITAYDHSRVHLHPTPGQKKNLDYINANFIDGYQKGHAFIGTQGPLPDTFDCFWRMIWEQRVAIIVMITNLVERGRRKCDMYWPKDGVETYGVIQVKLIEEEVMSTYTVRTLQIKHLKLKKKKQCNTEKLVYQYHYTNWPDHGTPDHPLPVLNFVKKSSAANPAEAGPIVVHCSAGVGRTGTYIVLDAMLKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAIASGETNLMAEQVEELKNCTPYLEQQYKNIIQFQPKDIHIASAMKQVNSIKNRGAIFPIEGSRVHLTPKPGEDGSDYINASWLHGFRRLRDFIVTQHPMAHTIKDFWQMVWDHNAQTVVLLSSLDDINFAQFWPDEATPIESDHYRVKFLNKTNKSDYVSRDFVIQSIQDDYELTVKMLHCPSWPEMSNPNSIYDFIVDVHERCNDYRNGPIVIVDRYGGAQACTFCAISSLAIEMEYCSTANVYQYAKLYHNKRPGVWTSSEDIRVIYNILSFLPGNLNLLKRTALRTEFEDVTTATPDLYSKICSNGNVPQHVILQQQQLHMLQLQQQHLETQQQQQQQQQQQQQQQQTALNETVSTPSTDTNPSLLPILSLLPPTVAPLSSSSSTTPPTPSTPTPQPPQTIQLSSHSPSDLSHQISSTVANAASPVTPATASASAGATPTTPMTPTVPPTIPTIPSLASQNSLTLTNANFHTVTNNAADLMEHQQQQMLALMQQQTQLQQQYNTHPQQHHNNVGDLLMNNADNSPTASPTITNNNHITNNNVTSAAATDAQNLDIVG
149
Q6C9C2
2.7.7.7
ACT_SITE 449; /note="Nucleophile; Schiff-base intermediate with DNA; for 5'-dRP lyase activity"; /evidence="ECO:0000256|PIRSR:PIRSR622312-50"
MGPRATRNSSKNTEGAETASKDAQSQHNAASDTKQASKEVSSTATSPKVALKRQHRTAASTNSDESSSKPSTPTGSVTSTVESPRKAKKTDAVVEGEQPETTVKQEPDFESTVKIEPIEVVKTEDPGHDIKVEDRDIKTEEDTKAGGNASREEIKNEYHSTPNLPLFHAITVMFIPLSKTNKHRAELCSRHGGTVVTSYSDKVTHIIVANGVTVPQLMKTLGVDTLPASVTVVNENWFADCIEAGKIVGFGGKEVLGVPRGGDKRTAETTSDDTDAKKRRRASDAPSRSTTPPASPKSRSELRSDVSSDVIKARGKSMLEALHDVRMQDHAHAFASEWEDDGDDDADTDDDDADEPHKHKKSQPQKQGDWVDNFLCMSGPERDPVDKNPNWKTIEVLSRLLKYYEDKHDQWRAQSYRKALNVLKRQPKKITTKKEAVKLPGIGDSIGSKIQEIVETNGLKLLNVTKLDTSVKVTSLFEGIWGVGKATARKWYKEGYRTLDDIAKKATLTPNQKVGLEHYDDFQERIPRDEVTRHFMVVQKAAHEIDPEVDAHIMGSYRRGAASSGDIDMIFTKKGATLDELQPFLKELVHKLTEQGFLKCGLTGASTKWYGCSKLKDIPQWRRIDFLLVPWAEKGAAFIYFTGNVLFNRSIRLLANKKGYSLNQHGLYAGVLRGERGSKLNDGYLVEGESEHKIFEILGVPYWEPWERNV
121
Q8WTX9
2.3.1.225
ACT_SITE 164; /note="S-palmitoyl cysteine intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00067"
MYKMNICNKPSNKTAPEKSVWTAPAQPSGPSPELQGQRSRRNGWSWPPHPLQIVAWLLYLFFAVIGFGILVPLLPHHWVPAGYACMGAIFAGHLVVHLTAVSIDPADANVRDKSYAGPLPIFNRSQHAHVIEDLHCNLCNVDVSARSKHCSACNKCVCGFDHHCKWLNNCVGERNYRLFLHSVASALLGVLLLVLVATYVFVEFFVNPMRLRTNRHFEVLKNHTDVWFVFLPAAPVETQAPAILALAALLILLGLLSTALLGHLLCFHIYLMWHKLTTYEYIVQHRPPQEAKGVHRELESCPPKMRPIQEMEFYMRTFRHMRPEPPGQAGPAAVNAKHSRPASPDPTPGRRDCAGPPVQVEWDRKKPLPWRSPLLLLAMWGPQAPPCLCRKRGRGACIKCERLRPRIRRRGLGPPAAAPARRRIPRTPALCTPLALPAPTTRRRQSPWTRFQWRRRAWAAPLWPPRGAGADSPRWRGRRVRPPFS
57
A0A0A0KC15
3.1.3.16
ACT_SITE 352; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR033096-1"
MSNNNSNVTPAEKIKCRANKAFAAHKYAQAIDLYTQAIELNNQNAIYWANRAFAHIKLEEYGSALEDASKAIEVNPRYSKGYYRRGAAYLAMGKFKEALKDFQQLKKMCPNDPDTIQKLKECEKAIGKLNSEEAVAAPLPETDSVANSIDVHRVGVSSTSVPTQMAIVAAAVATTAIAISTLSTKVATVVAAIAVVVLIIMGTRWWGGSGCVINAKTLDVDPQYSGARIEGDIITLDFVKKMIDNFKNQKPLHRRYVFQILQQTKKILKALPSLVDITIPEGKRLTVCGDVHGQFYDLLNIFELNGLPSEDNPYLFNGDFVDRGSFSLEVILTLFAVKCMSPSAIHLSRGNHESKTMNKMYGFEGEVKTKLNGTFVELFAEVFCCLPLAYVLNEKVFVVHGGLFSVDGVKLSDIRMINRFCEPPEKGLMSDMLWSDPQPYPGRGPSKRGVGLSFGADVTKRFLEDNKLDLLVRSHEVKDEGYEIAHDGKLITIFSAPNYCDQMGNKGAFIRFETPDMKPNIVTFSAVPHPDVKPMAYANFFQFFQ
144
Q8RHB2
5.6.2.2
ACT_SITE 118; /note="O-(5'-phospho-DNA)-tyrosine intermediate"; /evidence="ECO:0000256|HAMAP-Rule:MF_01897"
MSNVDNRYIEEELKESYLDYSMSVIVSRALPDVRDGLKPVHRRILFAMNEMGMTNDKPFKKSARIVGEVLGKYHPHGDSAVYGTMVRMAQDFNYRYLLVEGHGNFGSIDGDSAAAMRYTEARMEKITAELLEDIDKDTIDWRKNFDDSLDEPTVLPAKLPNLLLNGAIGIAVGMATNIPPHNLGELVDGILAIIDNKDIEILELMNYIKGPDFPTGAIIDGRVGIIDAYKTGRGKIKVRGKVDIEELKNGKSNIIVSEIPYQLNKANLIEKIANLVKEKKITEISDLRDESNREGIRILIEVKKGEEPELVLNKLYKYTDLQTTFGVIMLSLVNNVPRVLNLKEMLNEYIKHRFDVITRRTAFDLDKAEKRAHILKGYQIALENIDRIIELIRASSDGTVAREQLIEKYAFTDIQARSILDMKLQRLTGLEREKIDTEFKEIETLIKELREVLEDNNKIYDIMKKELLELKEKYGDKRRTKIEEERMEILPEDLIKDEEIIITYTNKGYVKRIEASKYKAQRRGGKGVSALNTIEDDYAEKITSASTLDTIMVFTDRGKVYNIRAYEIPDLSRQSRGRLLSNIINLSEGEKVRDTIVIKEFSPEKEVVFITKKGLIKKTSLGEFKNINNSGLIAIKTREDDDLIFVGLIEDVNKEEILIATHDGYCTRFLTDTIRATGRSTQGVKAITLREGDAVVSAMLIKNPETDILTITENGYGKRTSLDEYPQYNRGGKGVINLKASEKTGKVVSVLEVTEDEELMCITSNGIVIRTSISEISRIGRATQGVRIMKVADDEKVAAITKIKKEEELED
222
Q8P8H6
3.1.1.11
ACT_SITE 256; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MSASHIRTTCLATALLSLISLDAAALTGTASRPQLTSSEAGTYTISKALAKAGPITALVTDNWNPTAGVALLTADFAVAADGSTRYRTVQSAIDAAVAAGGSTRRYISVKAGTYTELVCVPSGAPPLTLFGLGSATTDTVIRYNNANPTPKPTGTASHPCASNASAATVGTSNSATVTVRASGFQARHLRFDNNYVEGTYADNNQSAVALAVRGDQASFEDVLVTGNQDTLLISATNAANVIRAYFKSSTIEGDVDFIFGSGIGVFDNAIIRSAGARLGSSRGGYIFAPSTRPGSGYGFLAINSRFVAGSGSPDNQTYLGRAWDEGVSGLSAYVNGTSPNGQVTIRDSTLGSHIRKTAPWNASTASRPFCSRNCTNSANRFFSNTATAVLAVPTDPGRSVR
125
A0A6P9EVX0
3.1.1.11
ACT_SITE 422; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MTQIKELLTGKLQISHNYISVVKRKKKLVLAFSVTLLLVAAIVGIAAGVHSRGKNSGNRELSASAHAIVKSSCSSTLYPDLCYSALASVPGASAKLSSQKDVIEASLNITTEAVEHNFFTVKKLIKTRKDLTKREKTALHDCLETIDDTLDELHQAVEDLHEYPNKKSLSLHADDLKTLISSAITNQETCLDGFSHDEADKRVRKVLLAGQVHVEHMCSNALAMIKNMTDTDIANEGKTTSRKLKEEVDGVKWPEWLSAADRRLLQSSSVTPDAVVAADGSGDYKTVSEAVAAAPDNSKTRYVIRIKAGVYRENVEVTKKKKNIMFLGDGRTTTIITASRNVVDGSTTFTSATVAAVGERFLARGITFQNTAGPSKHQAVALRVGSDLSAFYECDMLAYQDTLYVHSNRQFFVNCLVAGTVDFIFGNAAVVFQDCDIHARRPNSGQKNMVTAQGRTDPNQNTGIIIQKSRIGATSDLEQVKSNFRTYLGRPWKEYSRTVIMQSSISDVIDPAGWHIWDGTFALDTLFYGEYQNTGAGAGTSKRVTWKGYKVITSASEAGAYTPGNFLAGSSWLGSTGFPYSLGL
125
A0A9R0HUN7
1.11.1.7
ACT_SITE 64; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MAISAAVVFSSILIFSAFSLGNALSLNHYVKACPEVENIIKNAVTEGFHKDKTVPAALLRLHFHDCFIRGCDASVLLDKDENNKVEKSGPPNLSLHAFFVIDNAKKAVEAACPGVVSCADILALAARDAVVAAGGPNWDVPKGRKDGRTSLASDTLQLPAPTFNLSQLQQSFARRGLNLGDLVALSGGHSLGFSHCSSFQNRLHNFDAAHNIDPSINPSFAANLNKVCPAHNKVKNAGSNMDPSPTLFDNTYYKLILQGKSLFSSDQALFTAPSTKHLVYKYAGSKEAFYKAFVKSMIKMSSITGGQEIRKHCRKVNS
14
A0A0K9PT86
5.1.3.15
ACT_SITE 168; /evidence="ECO:0000256|PIRSR:PIRSR016020-1"; ACT_SITE 272; /evidence="ECO:0000256|PIRSR:PIRSR016020-1"
MAESEEFLFMEKCKGVNGIDKIVLRQGRGISVEIYLYGAHVTSWKNDGEELLFMSSKTNFKPPKPIRGGIPICFPQFSDMGNLDKHGFARNKFWSIDDDPPSFPAMPSHKAFVDLILKPSGEDLRIWPHSYEFRLRIILGPGGDLMFTSRIKNTNTDGKPFSFKFAFHTYFSVSDISEVRVEGLETLDYLDNLKNRDHYTEQGDSIMFESEIDKIYLDTPSKIAIIDHGQKKTLVLKKEGLPDAVVWNPWEKKAKSLVDFGDDEYKTMLCVEAAAIEKSIVLKPGEEWQGKMDLMVNFSSYSSGYLDPKSAVL
210
A0A251VRS6
3.1.1.11
ACT_SITE 253; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MNTKKSILFWLSVIAIALFSIILSFYTTNSTIPTFEVTFVKRVIEQSGFYDLFSFISQITGRHRHHGHHHHHHRRRKVSCDADTWKNSRLISEYGVQLVLTVDQNGCGNFTTLQQAVDAVPDSSLNTTLIILDSGTYREKVLVNQTKTNLIIQGQGFLNTAIAWNDTANSTGGTIYSATVSVFAQNFIAYNISFKNTAPSPAQGVVGAQAVALRISGDQAAFYGCGFYGAQDTLLDDRGRHYFKECFIEGSIDFIFGNGRSLYEGCMLHSVASDVPSGGGISGAITAHGRNSVDEKTGFSFVYCIIRGSGRVWLGRAWGAYATVVFLKTYMSEVVSSDGWNDWRDPSRDQTVFFGEYGCLGVGANTTFRVPYMKTLSDEEATPFMDISFIDGNDWLLRNDKNI
125
A0A9J7MKE3
2.4.1.18
ACT_SITE 347; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR000463-1"; ACT_SITE 402; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR000463-1"
MATKMDVDEDVGPAPPDLNRLYDLDSYLKPFDKEIKRRYKCFVEVLEHINQHEGGLEKFSRGYENFGIHVTEDGGLVMREWAPGAVELYLMGDFNGWNKTSHSFEKKPFGKWELVLPPKDDGSCPLDHLSKYKLVVKDKNGHLLERICPWAKYTIPSNETKIYEAMFWNPPEKYVFQQSRPATPRSLRIYESHVGISSWEGKVADYKHFAYNVIPRIKKQGYNCIQMMAIMEHAYYASFGYQITSFFAASSRYGPPDDLKLLIDTAHKEGITVLLDVVHSHASKNVLDGLNQFDGTNACFFHAGSRGNHDLWDSRCFDYTNWEVLRFLLSNLRWWMEEYQFDGFRFDGVTSMLYHSHGIAHGFSGGLGEYFGLPTDSESLTYLTLANHMLHELYPNCITIAEDVSGMPALCRPVSEGGNGFDYRLGMAIPDKWIKILKEYKDEDWNIGDIVHTLINRRHGEKTIAYAESHDQALVGDKTLAFWLMDAEMYTNMSCSSEMTVTVDRGLALHKMIRLITHGLGGEGWLNFIGNEFGHPEWLDFPRVGNNSSFHYARRQWNLVDDDLLRYKFLNNFDRDMNLTENHFGWLADKQAYVSSKHEGDKVVVFERGGCVFVFNFHTHQSYTGYRIGCDVPGKYKIVLDTDDPAYGGHSRLDHTTEFFTEPIEHDKRANSIQVYMPARTGFILAKQDD
73
P05653
5.6.2.2
ACT_SITE 123; /note="O-(5'-phospho-DNA)-tyrosine intermediate"; /evidence="ECO:0000255|HAMAP-Rule:MF_01897"
MSEQNTPQVREINISQEMRTSFLDYAMSVIVSRALPDVRDGLKPVHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSVDGDSAAAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDITIPELMEVIPGPDFPTAGQILGRSGIRKAYESGRGSITIRAKAEIEQTSSGKERIIVTELPYQVNKAKLIEKIADLVRDKKIEGITDLRDESDRTGMRIVIEIRRDANANVILNNLYKQTALQTSFGINLLALVDGQPKVLTLKQCLEHYLDHQKVVIRRRTAYELRKAEARAHILEGLRVALDHLDAVISLIRNSQTAEIARTGLIEQFSLTEKQAQAILDMRLQRLTGLEREKIEEEYQSLVKLIAELKDILANEYKVLEIIREELTEIKERFNDERRTEIVTSGLETIEDEDLIERENIVVTLTHNGYVKRLPASTYRSQKRGGKGVQGMGTNEDDFVEHLISTSTHDTILFFSNKGKVYRAKGYEIPEYGRTAKGIPIINLLEVEKGEWINAIIPVTEFNAELYLFFTTKHGVSKRTSLSQFANIRNNGLIALSLREDDELMGVRLTDGTKQIIIGTKNGLLIRFPETDVREMGRTAAGVKGITLTDDDVVVGMEILEEESHVLIVTEKGYGKRTPAEEYRTQSRGGKGLKTAKITENNGQLVAVKATKGEEDLMIITASGVLIRMDINDISITGRVTQGVRLIRMAEEEHVATVALVEKNEEDENEEEQEEV
222
Q39183
2.7.11.1
ACT_SITE 316; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MASTRKPSGHGAEVEAQKRSSSNSSTKSAKAETFEPMQLQRSVTNPRAVGIPESKRLPESFRKRSSDPAVCKPDFSSLSTVLEHVDSLTIDEKKTSGFGSVKTSSASAKLSDGTSSLGKTSGSAKLSGRLDFMESGKSSICRGSTSSDVSDESSCSSFSSTVNKPHKANDLRWEAIQAVRVRDGLLGLSHFRLLKRLGCGDIGSVYLSELSGTKCYFAMKVMDKTSLASRKKLLRAQTEREILQSLDHPFLPTLYTHFETEKFSCLVMEFCPGGDLHTLRQRQPGKHFSEQAVKFYIAESLLALEYLHMLGIVYRDLKPENVLVREDGHIMLSDFDLSLRCLVSPTLVKSAAIESDPLRKNVYCVQPACIEPSCIQPSCTVPTTCFSPRLFSSKSKKDRKPKNDTANQVRPLPELVAEPTDARSMSFVGTHEYLAPEIIKGEGHGSAVDWWTFGIFLYELLFGRTPFKGSGNRQTLFNVVGQPLRFPETPVVSFAARDLIRGLLMKEPQQRLGFKRGATEVKQHPFFEGVNWALIRCATPPEIPKPVELEKGAVSVAEAPSSQKTAAGLVLNAQKGSDNYLEFDFF
99
A0A1U7YTJ2
5.1.3.3
ACT_SITE 192; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1"; ACT_SITE 324; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1"
MANLSQLLCFIFVAFALLHVSSANEANVGIYQIKKGNFYVNLTNWGARITSIVLPDKQGNLGDIVLGYDTLDEYKTDTSYFGAIVGRVANRIKGAQFTLNDTTYNLVANDGKNTLHGGQKGFSDVVWQVKKHSPASHCPYVRFHYQSADGEQGFPGKVIVSVNYMITVENQLSVTMKAKALNKATPVNLAQHTYWNLGGHNSGDILSETLQIFASQYTPVDSELIPTGEIAPVKGTPYDFGEPQTVGSRIDQLPNGYDINYVVDAEGGPRTMKKAAILSDSKSGRVMELRTSAPGLQLYTADKLKDIKGKNGAVYKPHAGLCLETQGFPDSLHHPDFPSQIITPKKTYKHFILYTFKTTKPSTN
211
Q6DHD6
5.1.3.3
ACT_SITE 173; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1"; ACT_SITE 307; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1"
MTEVHKEEFGTALGPVERWILRSASVSVEIISLGCVIKSIKTADRSGQSADIVLGFDDIEGYFSNPRYFGAVVGRVANRISKGRFVIDEKEYKLAINNGPNALHGGLKGFDKAVWSTEAVDNGVKLSHSSPDGDEGYPGNLKVSVTYTLEKSTLSVLYHAQTDHTTPINLTNHSYFNLAGEGTPDIYDHEVTISAESYLPVDDTVIPTGEVKPVEKTPFDLRKPVILGFRLKELSGPGFDHNFCLYLPGEPPLERKCARVVHPGTGRVLEVSTTQPGVQFYTSNFLDGSVKGKGGAAYSKHSAFCLETQNWPDAVNQPHFPDALLRPGETYSHTTRFTFSVV
211
H3GWW5
2.3.2.26
ACT_SITE 643; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
MDNERSTEASMLYQGVGMLLLCIIFFVVWLMACRRNRHLLDMEVPLLSGESVDHRIDAATREAEAGYSVCASCAFENFKRFEYCVLCGDKLPSLSFATADDESDDEQLKPEDTCSSRGGAINMAMSATHLLSPRPRKMSSLSRQQRRARSRREWTRKLDVEGNLFWYRSGGGGHVPANSDVDTLLPGYTLSFKLPEEVEQQELAEEQEQERTKEQEEQETMTETEPVPSLAVEQPQSEKENADDKPMLPTDVELELVEASVSDPADFATGKSTLADAGAERRKEVVSLATSDFPSKYAHFVVSTASLIVPAEVEFLKLSVHREYMLEESMDHMYCIQPKNLRSFMRINFLDESGVDAGGVHREWFMLVNELLASPTLRLFTCTNKADQSYFLNPQSRSEVGEDHLAYYFATGRLIGRALLEGGIWGFHLALPLLKVILGMPVTFADMEYLDPEAYRSLRWLMDNDGVDDLGLDFSLTEQVNETEKIVVDLIPNGRDIAVTDANKREYLDRRFRYVLFESVADQLHAFLKGLYEVIPREMLLIFDPEEFDYLLCGSPEVDVTDWETHTVLSPNLEGVSVTRWFWEIVRQMPNEYRRRLLLFATGSACVPLSGFRGLTSYDGRLCPFNLKGVPYRSTQYISSHACFNRLDLPLYHSKKELKSMLYATLDTDLTGFTTA
65
A0A022RLC9
3.1.1.11
ACT_SITE 347; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MQSRIEGHDVHTPQTVLKAALQNTIKEAMLAIDTISTFNTLSISYREQIAIEDCKELLDFSVSELTWSLSEMNKIRAGSKNPRSDGNLKAWLSAALSNQDTCLEGFEGTDRRLERFVRGSVSQVTQLIGNVLTLYVQMHRLPFRPPRSYTNATSTNYDDDNNGDENGDGRDFPTWMTDGDKELLVSERSNNNNGMHVDSVVALDGSGRYRSIGQAIFEAPSYSKRRYVIYVKKGVYQENIDMKKKKSNIMLVGDGIGKTIITGNRNFMQGWTTFRTATLAVSGKGFIARDMTFRNTAGPEKHQGVAIRVDSDQSAFYRCSFEGHQDTLYAHSLRQFYRECTISGTIDFIFGNGAAVLQNCKIFTRDPLPLQKVTITAQGRKDPHQSTGFTIQDSYVYATRPTYLGRPWKQYSRTVYMNTYMSSMVQPRGWLEWYGDFALGTLWYGEYRNYGPGSSTSGRVQWPGYHIIGDASTAGFFTVGRFLDGVSWLPATGVKFTAGLTN
125
A0A0D1BX81
3.4.25.1
ACT_SITE 45; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR600243-1"
MSAAMAHAFPGSSTSSSGFDFSNYSRNTFLSNQGLGGFTATSTGTTIVGCIFKDGVVLGADTRATEGPIVADKNCEKIHYISDNIRCCGAGTAADTEFVTQLISSNMQLHELNTGRQPRVVTAMTMLKQRLFQYQGHIGAALVLGGYDATGPHLFTVAPHGSTDKLPYVTMGSGSLAAMAVFESGWVKDMERADAIGLVAAAISSGIFNDLGSGSNVDVCVIEKGKTEYLRNYETPNERVSKEQRYQFPRGTTAFTKQQIYDMIRKEDVLEIGNKAAVPVPAAAPGEERMDTS
180
Q0U8Y6
3.1.3.3
ACT_SITE 174; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR604469-1"; ACT_SITE 176; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR604469-1"
MATRPPALDVSPTHLVATLFYKSDSPHFFQHADLSPRSPNDQLPSASLEALKDGAAPTENLADYPLEPPTPGPSALDNLYGSYLSQSCLTDFFVTLTNILPGLEQSTITSRKLEAAKLCRVVEVTFPLPSASPIALETLRRDEAVSRFEREWNVECVFQADNIYRRYKRLAVFDMDSTLIQQEVIDEIASLIGVEKEVSAITAAAMNGELDFEASLRARCKLLKGVPSTVFETLRPRITLNEGVKELITGLKKLGFKTAVLSGGFTPLTSWMGQQLGLDYAFANHLVVSEDGKTLTGELTGEIVHAQKKRQHVLEIAEKEGILLDQVIAIGDGANDLPMMGVAGLGVAFHAKPNVQMQAPARLNSKSMQDVLYLFGITKEEQQVLLQ
147
Q9FM79
3.1.1.11
ACT_SITE 221; /note="Proton donor"; /evidence="ECO:0000250|UniProtKB:P0C1A9"; ACT_SITE 242; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:P0C1A9"
MKVEAFIPAVLLLCFGVMLCLKSSCALQIGNNNELKNYISWEDLRVVEDGRIERSFSIKENSNWVTTNANANANATNVRRVIVVDKNGGGDSVTVQGAVDMVPDSNSQRVKIFILPGIYREKVIVPKSKPYISFIGNESYAGDTVISWSDKASDLGCDGKELGTYRTASVSIESDFFCATAITFENTVVAEAGEQGRQAVALRIIGDKAVFYRVRVLGSQDTLFDDNGSHYFYQCYIQGNVDFIFGNAKSLYQDCDIHSTAKRYGAIAAHHRDSETEDTGFSFVNCDISGTGQIYLGRAWGNYSRTVYSNCFIADIITPVGWSDWKHPERQRKVMFGEYNCRGRGAERGGRVPWSKTLTRDEVKPFLGREFIYGDQWLRL
125
Q9X0I1
6.3.4.4
ACT_SITE 12; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00011"; ACT_SITE 40; /note="Proton donor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00011"
MNRVVVGLQWGDEGKGKVVTYLSRYHDIVARFSGGANAGHTVNYGDFKVIHHLLPSADFTKNRGIAIGSGVLLDPQVLTEELRELKEKFPDYSGEIFISESAHVVLPVHKEMDRIIDEVLKIGTTKRGIGPACADRVMRVNVRVAELGNEEKLRYFLEKNLSLKKIYGVDFDAEKMMGDLSTFYETIKDFVVSPVQLKRILEEKSVLFEGTQGVLLDLDVGTYPYVTSMNCSSSGVSAGMGFPVEVDEVLGVFKAYTTRVGEGPFPTELTGEEGEKLRKAGHEYGSTTGRPRRCGWLDLPLLRYAIEISGVDSLVMTKADVLNGFEKIKVCVRYSDGRDLVSLRDLEKKEPVYEVFDGWKSLEDKNFERFVDFIERETGRPVRYISTGEKLEDIVEV
253
A0A3Q7IKN3
6.3.4.4
ACT_SITE 638; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03125"; ACT_SITE 684; /note="Proton donor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03125"; ACT_SITE 784; /evidence="ECO:0000256|PROSITE-ProRule:PRU10134"
MQMRQKLLFRSSPAICPHIVWGFVPVCLKHHINPVKHKLLHTSCQLILQSRGKRFGFLVNCLNGTIENSNNEQQTCYRNGEEISYDLYNESICELCTEGDIDKAMRLLSEMEALGFHPSFVSYSSLIAALGSVGRTSEADAIFQEMLCSSRKPRIKVFNILLRSFLRKGLLRLADKVLMLLDDLAVDRNQETYEILLEYYVSAGRLEDTWLIVAKMRRESYPLNSFVYSKIIELYRDNGMWKKALGIVEEIREMGLRLDKRLFNSIIDTFGKYGELGEALGMFDKMRQEGIKPDFRTWNSLIRWHCKYGHLDTAIELFNEMQEQGLYPDPKIFIIINTHLVEQGRWDDIDTILESMQGRGHHKSGAIYAVLVDIYGQQGRFEDAEYCLNALKLEGLQLSPSIFCVLAHAYAQQGLCEQTVKVLQIMEAEGMEPNLIMLNMLINAFGNAGRHMEAQSIYQHIKEMGITPDVITYSTLMKAFLRAKKFDQFLQSEDDVQHQKLKTLLMLLSVIFEDFDAQPQMYFSSSAILLYQQRNRTPPGAATMNMSTMRLDASSITTAKATATAKVSHRSGTIGYNGTNSCRLIQFQQRKKKASSMIVCSKNPLASVVDRQGVNESGLSRIESLSQVSGVLGCQWGDEGKGKLVDILAKHFDIVARCQINLLTMLAELFNNVFGCKGGANAGHTIYNSEGKKFALHLVPSGILNEETLCVIGNGVVVHLPGLFNEIDNLESNGVSCQGRILVSDRAHLLFDFHQEVDGLREAELDKSFIGTTKRGIGPSYSSKVIRNGIRVSDLRHMDTFPQKLDLLLSDAASRFQGFKYCPDMLREEVERYKKFAERLEPFVTDTVHFMNDAISQKKKILVEGGQATMLDIDFGTYPFVTSSSPSAGGICTGLGIAPRVVGDLVGVVKAYTTRVGSGPFPTELMGEYGDLLRSAGQEFGTTTGRPRRCGWLDIVALRYCCQINGFASLNLTKLDVLSDLSEIQLGVTYRHPDGSTLNSFPSDLSLLEQIKVEYEVLPGWKTDISSIRKYSDLPKAAREYVERIEELVGVPIHYIGIGPGRDALIYK
253
A0A6I8NK18
3.1.4.11
ACT_SITE 327; /evidence="ECO:0000256|PIRSR:PIRSR000956-1"; ACT_SITE 374; /evidence="ECO:0000256|PIRSR:PIRSR000956-1"
MSLLSPILLPPEVKSYLSRGERFIKWDDDTTLASPVILRVDPKGFYLYWTYQSKEMEFLDITSIRDTRFGKFAKMPKTQKLREVFNLDFPDNTFLLKALTVVSGPDMVDLTFHNFVSYKENVGQTWAKDVLTLAKDPLTANASRSTFLEKILVKLKMQLNPEGKIPVKNFFQMFPADRKRVEAALSACHLAKGKNDSINPEDFPEPVYRSFLMNLCPRPEIDEIFTSYHAKAKPYMTKDHLTEFINKKQRHSGLNSLLFPPARPEQVQGLIDKYEPSGLNIQRGQLSPEGMVWFLSGPENSVVAQDKLLLHQDMSQPLNHYFINSSHNTYLTAGQFSGISSPEMYRQVLLSGCRCVELDCWKGKPPDEEPIITHGFTMTTEIPFRDAIEAIAESAFKTSLYPVILSFENHVDSPRQQAKMAEYCRTMFGDMLVTEPLDKFPLKPGVPLPSPQDLLGKILIKNKKNQFSASPPPPEEEDSSGEPLSSGDNPRVQGGDTARASEEEAEEVEEEEQEESGSLDEEEMKKMQSDEGTAGLEVTAYKEMSSLVNYIQPTKFISFEFSAQKNRSYVISSFTEMKAYDLLTKAPVQFVDYNKRQMSRIYPKGTRMDSSNYLPQMFWNAGCQMVALNFQTPDLPMQQNMALFEFNGQSGYLLKHEFMRRPDKQFDPFSVDRIDVVVASTLSITVISGQFLSERSVRTYVEVELFGLPGDPKRRYRTKLTPSANSINPVWNEEPFVFEKILMPELASLRVAVLEEGGKFIGHRIIPVNAVHSGYHHLCLRSESNVPLTMPALFIFLEMKDYVPDTWADLTVALANPIKFFNAHDKKSVKLKEAGDTPPEPFQLRTSAPAQANGTSTSTGSSAAPSSNGPAAALVWAKEEALREAAEPQTASLEELQQLKSFVKLQKRQEKELKELERRGGRRREEVLSKYATLLAELDAQGGGKKVSCGKSIRKKRSLPWEEGGGTWQGEGSDDSDSRVREQLREKLETELLQHGEDHYRGLLKRKEQHIGEQMAKVTELARERHTAELKALKESAESDTKEMKKKLEARRLERVQATSKSASDKMAQERVKREINNSHIQEVVHIIKQITDNLVRHQEKLEEKQLACLEQIREKEKRVQKEALSEYEERMNGLGDEVQEAIRACLGGCLPPTAQPRKPEALDLRGRPSPA
153
Q9V4E5
2.7.10.1
ACT_SITE 868; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000666-1"
MKMVGCHPNDKKVKYDGIKSKTSSVTILTSVLNDAISALKSAFYKNQAPISEQNRSQIVSRMSLLRTILLIIISIHFKLAHADQVVLLDTTREATLEWTRYPYGPQAQTPGWVEESFTDFVKGINWRSYVVCDVAYHNVNNWLWSPFIDRGSANRLYIEIQFTIRDCSLFPGNALSCKETFSLLFYEFDAATREPPPWQTDSYRLIARIAAGEGRFNQNSDVDINTEVKSIAVNKKGVYFAFRDQGACISVLAVKVYYITCPAVTENFAHFNETPTGREITIIEKQNGTCVDNAEPYETPTYLCKGDGKWTILTGGCRCKAGYEPNYTNKTCTECPLGTFKSPEVTKCTPCPPNSNASKTGSPFCKCASGFYRHPNDGRHMPCYSPPAAPTNLTLLFVDQTSAIISWSAPAKNESFSSETNSKIYHSDIVYKIKCNICSPNVVYNPSTDTFNETKITLTNLEPVTTYTVQIHAINSVSHINEFKRHSNESSLVAVSDIVFSNTSLLNIPLDLNEVKTGQAEIVFTTESVLLSTVFNLRILAITNKDADLEWDKPVQSDFPLEFYEVRWFPKVELDAINKSALNTKETKAHIVGLLENTEYGFQVRCKTNNGFGSYSNMIYAQTLQSVGSVYDDSVQIRFIAGAIVTGVLFLVIFIIATVYFMRSKHQDDLDKKSTNHLPLPLDYASNEVNSMDTTPIVKKLHLNVTTPLFGNSRSYVDPHTYEDPNQAIREFAREIDANYITIEAIIGGGEFGDVCRGRLKIPPNFVQDIDVAIKTLKPGSSEKARCDFLTEASIMGQFDHPNVIYLQGVVTRSNPVMIITEYMENGSLDTFLRVNDGKFQTLQLIVMLRGIASGMSYLSDMNYVHRDLAARNVLVNAQLICKIADFGLSREIENASDAYTTRGGKIPVRWTAPEAIAFRKFTSASDVWSYGVVLWEVMSYGERPYWNWSNQDVIKSIEKGYRLPAPMDCPEALYQLMLDCWQKQRTHRPTFASIVSTLDNLARQPQSLLTTRPSPESDGNHILDGQRGQNIFISTDLWLEHIKMSRYCHHFKEANLINAQQISRLTAQQLSDMGITLVGHQKKILHQARQLDTII
97
Q2UIM2
3.2.1.55
ACT_SITE 229; /note="Nucleophile"; /evidence="ECO:0000250"; ACT_SITE 305; /note="Proton donor"; /evidence="ECO:0000250"
MSSGLSLERACAVALGIVASASLVAAGPCDIYSSGGTPCVAAHSTTRALYSAYTGALYQVKRGSDGSTTDIAPLSAGGVADAAIQDSFCANTTCLITIIYDQSGRGNHLTQAPPGGFNGPESNGYDNLASAVGAPVTLNGKKAYGVFMSPGTGYRNNAASGTATGDKAEGMYAVLDGTHYNSACCFDYGNAEVSNTDTGNGHMEAIYYGDNTVWGSGAGSGPWIMADLENGLFSGLSSTNNAGDPSISYRFVTAVVKGEANQWSIRGANAASGSLSTYYSGARPSASGYNPMSKEGAIILGIGGDNSNGAQGTFYEGVMTSGYPSDATENSVQADIVAAKYAIASLTSGPALTVGSSISLQVTTAGYTTRYLAHDGSTVNTQVVSSSSTTALRQQASWTVRTGLANSACLSFESVDTPGSYIRHYNFALLLNANDGTKQFYEDATFCPQAGLNGQGNSIRSWSYPTRYFRHYENVLYVASNGGVQTFDATTSFNDDVSWVVSTGFA
171
W5NJ28
3.1.3.48
ACT_SITE 1116; /note="Phosphocysteine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR000934-1"
MPFRLKLCRTRRYNVLSKNCFVTRIHLLDNNVIECTLSVESTGQECLEAVAQRLELRETHYFGLWFHSKSQLQRWVELEKALKKQLDKFGNEPLLFFGVMFYVPNVSRLEQEVTRYQYYLQVKKEVLDGRLQCTVEQGIRLAGLAVQADFGDFNHFQSQDFLREYVLFPVKWTQDEEVLEELTQKVAEEHKSHCRMPPAEAELLYIKEVERLEGFGQESFTAKDNFASDIYLGVSFMGVFVKHRNGRSTIVYRWNDIGNITHNKSAITIELTNKEETVLFHTDDMEMAKYISRLFTARHKFYKQNKICTEQSNSPAPIRRRPTWSRSSLQRPQSYILQPMHTQYGEHYQETRTSQDSIFHEDINPYYKSQTSLDRCPVDYAFMNGTVPNGSVYSTPSMNSLNHSQTFIQASPMSSNLSIPGSDIMRQDYIPSHRHSAIIAPSYRPTPEYEAVMRQKRGIVHMDHSQSLRNLNISNTFAYRQPEGMVYSQPEMRERQYPSPYGPQVSYSKPVAPSAHVNPSNSAASQAAASAISHTVSTPELANMKQQGTQGYSTAHMLRNHFSRPPPPYPRFRPATSTPDLASHRHKYISGSSPELVTRKVQLSVKTFQPDSSPVVHQSLQEVSEPLTAVKHHPSVNKRHSLEVISSMVRGMEAMALKTLNAPLPRRNTLREQVQPKESIQKAQEATAQYQHKKTLSNATMLIHSSESEEEEEETPDYDVQIPGLNEDISAQLQAALAKIPNKPPPEYPGPRKTVSNGTLRHERNQGTEEAARMRMMKAGQSQVTPHSRSEQIAVSGSLLGPSISEPDLTSVKERVKKEPVKERPVSEMFSIEDSIVEREIMQRTLEKQKMAMDSLKRPLMMAALNGLYVSRMPVPENQQDDSSKVTTDERCKILERKLEEDRVFTEYEQIPKKKVDCVITTAILPENVERNRFRDVVPYEENRVELVPTKENNTGYINASHIKVTISGEEWHYIATQGPLPGTCQDFWQMVWEQGVNVIAMVTAEEEGGRPKSHRYWPKLGSKHNSATYGKFKVTTKFRTDSGCYATTGLKVKHLLSGQERTVWQLQYTDWPDHGSPEDVQGFLSYLEEIQSVRRHTNSMLDTSKSLNPPIVVHCSAGVGRTGVVILTELMISCLEHNQKVDVPMMLGKLRQQRMLMVQTISQYQFVYQVLIQFLRNSRLI
149
F6HGE3
1.11.1.7
ACT_SITE 92; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MHFSTPSCFLLPILALLLISASSAQYEEHEEELTDPLTYLENPSLNEMLPGLSFSYYRQTCPDLEAIINRKVKEWIDKDYTLAASLIRLHFHDCAVKGCDASILLDHPGSERWADASKTLRGFQVIDDIKAEVERKCPKTVSCADILTAAARDATILSPAPGDATGLDLVRVPFWMVPYGRKDGRVSIDKEAQTVPMGRENVTALLEFFQSKGLNVLDLVVLSGAHTIGRTTCGAMQHRLYDFHGTGEPDPSISPKYLKFLRRKCRWASEYVDLDAITPRTFDVMYYKNLQHNMGLLATDQMLGSDSRTSDLVATLVSKPSIFYSQFALSMEKLGNTQVLTGEDGEIRVNCNFVNP
14
Q819W7
3.4.21.89
ACT_SITE 39; /evidence="ECO:0000256|PIRSR:PIRSR600223-1"; ACT_SITE 80; /evidence="ECO:0000256|PIRSR:PIRSR600223-1"
MKKEKSSLWEWIKAILIAVVLAGVIRQFFFAPILVDGVSMAPTLHDRDRMIVNKIGYHIGDPKRFDIIVFRATEDKDYIKRIIGLPGDEIEYRNDKLYVNGKAYEEPYLDKQKKQIADGPLTYDFNLEEMTGKKTVPKDQLFVLGDNRRFSKDSRSIGTISMDQVIGKANMLYWPLEDARIVK
178
A0A9R0IGR7
3.1.1.11
ACT_SITE 264; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MKLKSTTLFWLLAFVTALVSIAFTTTFFNSPSSNLSVVIKKATTLDEFLGVVKEIADGLLRRHHHHHHHHHSHHHHHHHHHHHHREMPDMACSESKWGSTLSSSYRVSLTITVDLHGCGNFSSVQKAVDAVPDFSSSFTLIILDSGLYKEKVMINANKTNLIFQGQGYQNTAIAWNDTSNSTGGTANSASVTIFAPGFIAYNISFQNTAPEPSPGDKGGQAVALKISSDKAAFYGCGFYGSQDTLNDDRGRHYFKDCFIQGSIDFIFGEARSLYQNCTINSIAQGNEQGVDGSITAHGRQSEDESTGFSFVNCKIGGIGRIWLGRAWGVYATVVFSNTYMSDVVSPDGWNDWRDPSRDSTVLFGEYECTGPGATYTNRVSYSKQLKLSEATPFLDISYIDGNDWLLPHQTTHSFYSPHTNKQTDFYLDSL
125
Q9HN88
2.7.6.1
ACT_SITE 185; /evidence="ECO:0000255|HAMAP-Rule:MF_00583"
MLLSGSSSQSLAAALAAATGERLGDVTYDSFPDGEQLVTVPPAVDGERAVIVASTPTSDAHIEVLQLQDAARDAGASEIITVLPYMGYARQDDAFDPGQPVSARAVARAISTGTDRVLTVNPHEDGVLECFDVPAAGVDAAPQLAAPLPADLTDPVFLSPDHGATDLATSVRDAYGTGVTDHFQKVRHSGSDVTVEPSEIQTAGRDVVVTDDIVATGTTMSEAITALDDPARVFVATVHPLLAGSARLKLARAGVEAVYGTDTIECAVSEVSAAPAIADAL
114
A0A8V0ZBR9
2.7.7.7
ACT_SITE 168; /note="Nucleophile; Schiff-base intermediate with DNA; for 5'-dRP lyase activity"; /evidence="ECO:0000256|PIRSR:PIRSR622312-50"
MHRCMRTAGSRPEPLIDHPRRALIQPREHRTSLLAAASPLRRRNGERRPRSLPAAAQQKSDPRLPHCVPQPVAVSARHRRRCCRVIFRCWSLPLPAMSKRKAPQESLNQGITDFLMELANYERNVSRAIHKYNAYRKAASVISRYPSRIRSGAEAKKLDGVGAKIAEKIDEFLSTGKLRKLEKIRQDDTSASINFLTRVTGIGPAAARKFVEEGIKTLEDLRKNEHKLTHHQRIGLKYFEDFEKRIPREEMLQMQEIVLKEVKNVDPNYIATVCGSFRRGAESSGDMDVLLTHPTFTSESSKQSKLLHQVIEQLEKVHFVTDVLSKGDTKFMGVCQLPNKEDGTLYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRTHALEMGFTINEYTIRPLGVTVSVMCLQELLGRPYQ
121
B1L6Y5
5.3.1.1
ACT_SITE 93; /note="Electrophile"; /evidence="ECO:0000256|HAMAP-Rule:MF_00147"; ACT_SITE 141; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_00147"
MHIPRLLINFKAYMESSGDRAVEISKSAERIWREMGVLIGVSPNIVDLRLISSSVEIPVFAQHVDPIPAGAYTGHVPPILVKEAGARGSLLNHSEKQIPLRHIAESINMMRDLNLISIVCSPTPSESAAVAALLPDAIAVEPPELIGSGIPVSKAKPEVILNSLRSVKAINSAIPLLCGAGISSGDDVKAALELGSYGVLVASAVTKSPDPQRKIRELAEPIASFTRA
213
W1NDS0
2.1.1.33
ACT_SITE 148; /evidence="ECO:0000256|HAMAP-Rule:MF_03055"
MASSKGLPRKRFYRARAHSNPLSDSHFPIPITPSDFNYSLHFPHFSNVNSNSEGQQKDSPLLVRFADVGCGFGGLLVRLSPLFPTTLMLGMELRDKVTEYVKERISALRDANPGQYGNISVVRTNSMKYLPNYIGKAQLQKLFFLFPDPHFKEKNHRRRVISPHLLAEYAYVLAPGGIIYTLTDVEELGAWMEGCLDAHPLFEPLSEEEVCTDPVAAILDSATEEGQKVARNEGQTFRSVYRRRVLPPTECSSG
45
Q9LM33
2.7.11.24
ACT_SITE 230; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
MGGGGNLVDGVRRWLFQRPSSSSSSSSSNNNNNNHEQPIFNSSSFSSSSNPNHSANSGELIIEEDLDFSGLTLINVPKRNHLPMDPHKKGETEFFTEYGEANRYQIQEVVGKGSYGVVASAVDSHTGERVAIKKINDVFEHVSDATRILREIKLLRLLRHPDVVEIKHIMLPPSRREFRDIYVVFELMESDLHQVIKANDDLTPEHYQFFLYQLLRGLKYVHAANVFHRDLKPKNILANADCKLKICDFGLARVSFNDAPTAIFWTDYVATRWYRAPELCGSFFSKYTPAIDIWSVGCIFAEMLLGKPLFPGKNVVHQLDLMTDFLGTPPPESISRIRNEKARRYLSSMRKKQPVPFSHKFPKADPLALRLLERLLAFDPKDRASAEDALADPYFSGLSNSEREPTTQPISKLEFDFERKKLVKDDVRELIYREILEYHPQMLEEYLRGGDQLSFMYPSGVDRFKRQFAHLEENQGKPGAAGGGRSTALHRHHASLPRERVPAPNGETAEESSDVERRAAAAVASTLESEEADNGGGYSARNLMKSASISGSKCIGVQSKTDKEDTIAEEEDNETVAELTDKVASLHNS
104
O23304
2.7.11.1
ACT_SITE 139; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
MARNKLEFPLDAEAYEIICKIGVGVSASVYKAICIPMNSMVVAIKAIDLDQSRADFDSLRRETKTMSLLSHPNILNAYCSFTVDRCLWVVMPFMSCGSLHSIVSSSFPSGLPENCISVFLKETLNAISYLHDQGHLHRDIKAGNILVDSDGSVKLADFGVSASIYEPVTSSSGTTSSSLRLTDIAGTPYWMAPEVVHSHTGYGFKADIWSFGITALELAHGRPPLSHLPPLKSLLMKITKRFHFSDYEINTSGSSKKGNKKFSKAFREMVGLCLEQDPTKRPSAEKLLKHPFFKNCKGLDFVVKNVLHSLSNAEQMFMESQILIKSVGDDDEEEEEEDEEIVKNRRISGWNFREDDLQLSPVFPATESDSSESSPREEDQSKDKKEDDNVTITGYELGLGLSNEEAKNQEGEVVGFDKDLVLEKLKVLKKSLEHQRARVSIIIEALSGDKEEKSREEELLEMVEKLKIELETEKLKTLRADKDSVLG
99
B9SEV4
3.4.19.9
ACT_SITE 200; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR615527-1, ECO:0000256|PROSITE-ProRule:PRU00607"; ACT_SITE 313; /evidence="ECO:0000256|PROSITE-ProRule:PRU00607"; ACT_SITE 313; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR615527-1"
MPSHSLSNSSSTPSIRPSSDLSNDAVALPSPPSSSSTPSDMWNYLWIPILISLSKELSLAKASRSNINSNNSNILLPSQLDDEPVPRCLAPDPKLNYRPVIGIVSHPGDGASGRLSNATNASYIAASYVKFVESAGARVIPLIYNEPPDILFEKLNLVNGVLFTGGWAKNGLYYDIVKAIFKKVLDKNDAGYHFPLYAICLGFELLTMIISKDRNILESFNAADQASTLQFMGNINIEGTVFQRFPPGLLKKLSTDCLVMQNHHYGISPERLQENQDLSGFFKILTTSADADNKVYVSTVQALSYPVTAFQWHPEKNAFEWGLSMIPHSEDAIQVTQHVANFFVSEARKSLNRPPARKVLDNLIYNFSPTYCGKAGKGYDEVYIFTEE
176
M9PCU5
3.1.1.3
ACT_SITE 214; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR000862-1"; ACT_SITE 388; /note="Charge relay system"; /evidence="ECO:0000256|PIRSR:PIRSR000862-1"; ACT_SITE 419; /note="Charge relay system"; /evidence="ECO:0000256|PIRSR:PIRSR000862-1"
MCINSKNNTHIHPSGVVDCTLIALSLCLLQSGIVEGISLSLGDITLFNVNFKTPTFLGRSVAVDSNVRLENDVDPNIQEDSHLNTYSLIKKYGYPAENHTLETDDGYILTLHRIARPGATPVLLVHGLLDSSATWVMMGPNKGLGYLLYDQGYDVWMANVRGNTYSRKHVKYSTHHAKFWDFTFHEMGKHDIPATMDYILNSTGVSQLHYIGHSQGTVVFWIMASEKPEYMDKIILMQGLAPVAFLKHCRSPVVNFLAEWHLSVSLVLKLIGVHEFLPKNEFISMFNRIICDETTITKEICSNVIFLTTGFDKLQLNETMLPVIVGHSPAGASTKQMQHFGQLNRSGGFRQYDHGWLRNHWIYGTIDPPSYHLENVRAKVALYYGQNDWLAPPEDVEMLNRKLPNVVEKYLVDDKEFNHLDFIWGIDARELLWDRMLEIMRNHENSII
128
D8RDK1
3.1.1.11
ACT_SITE 157; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
VVVDQDGNGDHASVQEAIDAVPVNNTVPITIFVSPGVYQEKVKIVESKPYITLQGSGADLTTIVWDDYAGKLGVDGSHLGTFHTATVHVSAPYFSARGITFKNSAPVQPAGSQAVAFQITGDMAAFYECNFIGAQDTLYDHSGRHYFKSCFIQGSVDFIFGNGRSLYKDCELNAIGSGALTAQKRQNASDNTGFSFVNCRILGNGLVYLGRAWGPFSRVVFLYCYMDSVINPGGWDDWGDSSRDMTVFYGEFNCTGPGANGMRRVPWSYVLTEAEAQPFLDERFIEGDAWLQ
125
A0A072U0A6
3.1.1.11
ACT_SITE 424; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MSSFKAYGKVDESAQAMFEVRRKSRKRITIICLSTVVLIGIVFAAVFGTIAHNNARNDDNNNNENDNNDQSLSSAIKAVCDVTLYKDSCEKSLSPLVQPGQQIRPEELFKLSIQVALTAVSKGVEYLSDHATFNDLNLNLDNRTKEALINCKDLFGLAVDDLNSSLSYGGKSSLLDVLEDLETWLSASGTYQQTCIDGLEQAEEALKSSITTNLKNSTEFTSNSLAIITWLNKAASSVNFRRLLSLSHQNEEPNWLHHKDRKLLQKDSDLKKKADIVVAKDGSGKYKTISAALKHVPNKSDKRTVIYVKKGIYYENVRVEKTKWNVMIIGDGMNVTIVSGSLNFIDGTPTFSTATFAVFGRNFIARDIGFKNTAGPQKHQAVALMTSADQAVFYKCSMDAYQDTLYAHSNRQFYRECNIYGTVDFIFGNSAVVLQNCNILPRQPMPGQQNTITAQGKTDPNMNTGISIQNCNVSPFGNLSSVKTYLGRPWKNYSTTVFMQSNLGNFISPNGWLPWVGDSAPDTIFYAEFQNVGGGASMKNRVKWKGLKTITSKQANKFTVKAFLNGDRWIPASGATFKSSL
125
A0A2I3RN08
3.1.3.3
ACT_SITE 20; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR604469-1"; ACT_SITE 22; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR604469-1"
MISHSELRKLFYSADAVCFDVDSTVISEEGIGELAKICGVEDAVSEMTWRAMGGAVSFKVALTEHLAPIQPSREQVQRLIAEHPPHLTPSISKRSRCSSRLQERNVQVFLISGGFRSIVEHVASKLNIPATNVFASRLKFYFNGKMSGVRDHPGQRGEAPTLLKKKKKKKKIGKLDAFIGFGGNVIRQQVKDNAKWYITDFVELLGEPKE
147
H3G8B9
3.2.1.21
ACT_SITE 168; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR617736-1"; ACT_SITE 381; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR617736-1"
MTKEIRFPDGFLWGAATASYQVEGAVNEGGRGASIWDAFSHTPGKTVNGDTGDVAIDHYHRYKEDVQLMKSMGLKAYRFSIAWPRIIPAGVGQVNEEGVQFYNNLINELLANGIEPMATLYHWDLPLALQTEFDGFLGEQIHDHFAQYARVCFEKFGDRVKNWITMNEPWVANYMGFGTGMLAPGRKHNKHFEPYLAGHNMLLAHARAVEVYRKEFQETQGGQIGITLSAEWKEPGPTDDPEQEKKNIAAAERAMAWSFGWFAEPVYYGDYPQIMKDRCGDRLPKFTEEQKKLLKGSSDFFGLNNYSSNFVKPSPEFEAGIPPPNDNTGGLEADEGVTGYHDPSWVQTGAPWNYVTPWGLKKLCAYIHEKYHPKNGIYITENGSAWPDVTKEEAQQDTQREDCYRQYIANVHEAITEGADVRGYFAWSFFDNYEWSMGYGIRFGMVWVDYKTQERVPKKSSYWYKQAIENNGFTV
161
A0A3B6PEM1
2.1.1.37
ACT_SITE 411; /evidence="ECO:0000256|PROSITE-ProRule:PRU01016"
MAPAPAGASPTRKRRSADEPPRVVTERATRGRPPREDGGPELVGDPIPADEARAKFPNRYHHQRRNGEGEEEEVEARCHYRAAKVEGTVYNLGDDAYVVAEEGRPHFIGRITELFEGTDRVKYFNCRWFFRSEDTVISTAELVGDHSHDPKRVFLSDERNDNPLDCIVSKVKVLQVDPKLDLEAKARLAADSDLYYDMSYTVPYSTFENITNDINEMSGISSDADSEADTSVATATLLDLYSGCGGMSTGLCLGAALAGLKLETRWAVDFNSHACKSLKSNHPKTEVRNEKADDFLSLLKEWAVLCDQYVHGNNAEAPPPMDDEEEEGELEKDEYVVQKLTDICYGGIDRKSCIYFKVQWKGYGPEEDTWEPIENLSHCPLKIKEFVQEGHMRKVLPLPGDVDVLCGGPPCQGISGLNRFRNRDDPLNDDKNRQLVTFMNIVSYLRPKFVLMENVVDILQFAEGYLGRYAVSRLVAMNYQSRLGIMLAGCYGLPQFRMRTFLWGALTTMVLPKHPLPTHNVVIRGGAPNAFTQSIVAYDETQNPTLKNALVLEDAISDLPKVGNDQADDVLEYLVKPKTEFQRYIRLSRKEMLDYSFGDKTGPGEGKLMDHCPLKLNKDDYERVKQIPFKKGANFRDLEGVRVGPNNVAEFDPEIPRVYLESGNPLVPEYAIKFRSGKSLRPFGRLWWDETVPTVVTAARPHSQRILHPGQARVLTVRENARLQGFPDYYRLDGPIKERYTQVGNAVAVPVARALGYSLGLAYLRKHDGSDDGPTLVLPANFFSPGQTEAAVAPAEADEVAEE
47
A0A078J5S8
3.2.1.143
ACT_SITE 280; /evidence="ECO:0000256|PIRSR:PIRSR607724-1"; ACT_SITE 298; /evidence="ECO:0000256|PIRSR:PIRSR607724-1"; ACT_SITE 299; /evidence="ECO:0000256|PIRSR:PIRSR607724-1"
MSFWKFGKAKRMEKKEYLGSFLKYLPLVAQSSSLAWPPSVEQELQTISEGPTKSMVNSGEVLASHITNMRKSLSLDACDLSPNPLLQGYATFFDKKISREESAKFFGEVVPALCGLLLQLPSMLETHYQNADHVLDGVTSGLRLLAPQEAGVVFLSQELIAALLACSFFCLFPEADRRSKHLQSINFDDLIWFPFMSYCSKRENKIRCLLHYFERVCQCMPTGFVSFERKVLPRGHKHNPHYVSYPDAEYWAKSTTPLCSVEIHTSGAIEDQPGEALEVDFADEYIGGLTLSYDTLQEEIRFVINPELIAGMIFLPRMDVNEAIEIVGVERFSRYTGYGPSFQYAGDYTDEKDFDAFKRRKTRVIAIDALPNPGSTQYKPERLLREINKAFSGYLHQCKHQAGPPPSSAVESSKRWCMDDHEEKIGVATGNWGCGVFGGDPEVKIMLQWLAISQSGRPFMSYYTFGLQALQNVNQVIERIGLQEMKVGELWSKLVEYSAERLSRSTRLGFFSWFMASLSATN
159
B7Q2F1
3.1.3.16
ACT_SITE 230; /note="Phosphocysteine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR620405-1"
MFAQSLPVGCKNYLEYCCFGLNSTANKNKIKRLKSLKSATMTTSLARGYGTRTLPPRSRFLGSSTSRTRQADQRRSLNLSCNPSSVYSCDREWRSPKYFSMSMARPAKKLCSIEELIRILVAPSNGYYELPTDPYNEVYPNIFISDGTTALCTGLLRRLGVTHVLNAAMGRDRMYCLINTSPSFYKSSGIEFHGVEALDLSSFKLDRFFQESADFIDKAIASGGKVLVHCKEGISRSATLVLAFLMLKRNLTAQEAVRLVRGRREIIPNQGFLQQLCELNERIHGRGSNEII
144
Q9RD27
3.5.1.88
ACT_SITE 169; /evidence="ECO:0000255|HAMAP-Rule:MF_00163"
MGTPSDRVPLAERVEELLAVGGPLPIVAAGDPVLRRAAEPYDGQVAPALFERFVEALRLTMHAAPGVGLAAPQVGVGLRVAVIEDPAPVPDEVRVARGRVPQPFRVLVNPSYEPAGAGRAAFFEGCLSVPGWQAVVARHAEVRLRAHDEHGRAVDEVFAGWPARIVQHETDHLDGTLYLDRAELRSLASNAAMAELWSQPTPRRAASALGFELPGPAA
183
F5HBY2
4.1.1.17
ACT_SITE 383; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR600183-50"
MAPSAITTTEEYQTLKDSLQSLNSQTLGSVENHGAWKSKQLIGSALKSRVEAIDHDSCDVGDEDAFFIADLGEVYRQHLRWKKNLARVKPHYAVKCNPDTQVLRLMSELGMGFDCASKNEIETVLKLGVDPARIIYAQPCKTKSYVRYAANSGVKQMTFDNADELYKTKQLFPDAELYLRILTDDSGSLCRLSQKFGASLDTTAELLELAHKLELNVVGVAFHVGSGASDPKAFIKAVQDARFVFDQAAAFGFDMHTLDVGGGFTGDITFEPMAAVLSASLDEYFPPHIRVIGEPGRYYVSTAFTIACHVIARRTVADATLGTTSYMLYLNDGVYGNFSSIIFDHQHPVPRVLKSGNDVLYDVRTSGYDTPSQVEYSIWGPTCDGIDIISSSCSFPELLDVGDWLYFEDMGAYTKCSATKFNGFTDSHDVVYVCSEPGAKALMGM
195
F7CT78
3.4.19.12
ACT_SITE 335; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR016308-1"; ACT_SITE 795; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR016308-1"
MAELSEEALLSVLPTIRVPKAGDRVHKDECAFSFDTPESEGGLYICMNTFLGFGKQYVERHFNKTGQRVYLHLRRTRRLKEEDPATGTGDPPRKKPTRLAIGVEGGFDLSEEKFELDEDVKIVILPDYLEIARDGLGGLPDIVRDRVTSAVEALLSADSASRKQEVQAWDGEVRQVSKHAFSLKQLDNPARIPPCGWKCSKCDMRENLWLNLTDGSILCGRRYFDGSGGNNHAVEHYRETGYPLAVKLGTITPDGADVYSYDEDDMVLDPSLAEHLSHFGIDMLKMQKTDKTMTELEIDMNQRIGEWELIQESGVPLKPLFGPGYTGIQNLGNSCYLNSVVQVLFSIPDFQRKYVDKLEKIFQNAPTDPTQDFSTQVAKLGHGLLSGEYSKPVPESGDGERVPEQKEVQDGIAPRMFKALIGKGHPEFSTNRQQDAQEFFLHLINMVERNCRSSENPNEVFRFLVEEKIKCLATEKVKYTQRVDYIMQLPVPMDAALNKEELLEYEEKKRQAEEEKMPLPELVRAQVPFSSCLEAYGAPEQVDDFWSTALQAKSVAVKTTRFASFPDYLVIQIKKFTFGLDWVPKKLDVSIEMPEELDISQLRGTGLQPGEEELPDIAPPLVTPDEPKAPMLDESVIIQLVEMGFPMDACRKAVYYTGNSGAEAAMNWVMSHMDDPDFANPLILPGSSGPGSTSAAADPPPEDCVTTIVSMGFSRDQALKALRATNNSLERAVDWIFSHIDDLDAEAAMDISEGRSAADSISESVPVGPKVRDGPGKYQLFAFISHMGTSTMCGHYVCHIKKEGRWVIYNDQKVCASEKPPKDLGYIYFYQRVAS
175
A0A9J7HD29
2.3.2.26
ACT_SITE 764; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR001569-1, ECO:0000256|PROSITE-ProRule:PRU00104"
MVQTRTIKKTLNPKWNEDFYFRVDPRCRLLFEVFDENRVTRDDFLGLVDLPLNNQIPTEYPDRERPYSHKDYLLRQRRAKNNTKSRVSGHLRLKLAYVPAVGWAEGQQQPNAEQQEDRDEVQIQNPGWEIVDMDTEPRQPQVQGNSPSQPSQPAAMPQGWEERQDANGRTYYVDHNTRQTTWHRPSISHAPGGLTAQAAEAAATTAQESNNRQAAQIFRQRRQISEDMSTPGGAGAAAAAAALVELPAQIASQPRQGPPPPKIHRMSVRSESQPHGQSDRGAEIEALPPGWEMRYTEGGRPFYIDHNTRTTSWHDPRQAAAASPQPHRSMMPRAATVTSPAAGTLDTPQVRQRAGSNPDLSHLGPLPSGWEERVHTDGRTFFIDHNTKNTTWEDPRLSRAFQNAALAGPAVPYSRDYKRKYEYFRSKLRRPANMPQNQKFEMKLHRNSILEDSYRTIMACKKADNLKAKLWIDFEGEKGLDYGGVAREWFYLLSHEMFNPYYGLFEYSANDNYTLQINPNSGLCNEEHLSYFKFIGRVAGMAVYHGKLLDAFFIRPFYKMMLKKPITLKDMESVDSEYYNSLVWITENDPEDLDLRFCVEEDQFGQMVTKNLKANGEDILVTNSNKKEYIDLVIKWRFSSRVQEQMKALMDGFNELVQQELLSIFDEREVELLMCGLGDIDVNDWRKHTAYRGDYSDKHPIIQWFWKAVILMDPETRVRLLQFVTGTSRVPMNGFAELWGSNGPQKFTIEKWGNPDQLPRAHTCFNRVDLPPYRSFQELWDKLKIAIENTEGFEGVD
65
A7F1Y2
2.7.1.11
ACT_SITE 164; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03184"
MAPQPPPPLEGKKRRIAIMTSGGDSPGMNGVVRACVRMAIYKGCEPYCIYEGYEGLVQGGKLIQKMGWEDVRGWQSEGGTLIGTARCMAFYERPGRLQAAKNMVLNGIDALIICGGDGSLTGADKFRAEWPGLIKELIEKKELSEEQVAPFKHLNIVGLVGSIDNDMSGTDATIGCFSALGKICEMVDYIEQTASSHSRAFVIEVMGRHCGWLALMAGVATGADFVFIPEKPRADNWKEEMCKIIQKHRQLGKRKTIVIVAEGAHDQGGNKISPDMIKDLLADKNGLALDTRISTLGHVQRGGSACAYDRYLSTLQGIEAVNAVLEATPETVTPFIAINENKITRKPLVQSVIDTQEVAKAIEARDFDRAMALRDAEFSDFHDSYMTTTATDLNNDMRLPDKKHMRIAIVHVGAPAGGVNAATRAAVAYCLTRGHTPIAIHNGFAGFARHHQDNPGSVREFDWLEVDGWASKGGSEIGMNRELPSESGMPLIASLFEKFKIDGLLIIGGFEGFHALSELRQAREKYSSLCIPMTLLPATISNNVPGTEYSIGTDTCLNELVRYCDTIKQSASASRRRVFVIETQGGRCGYVATMAGLAVGASAVYTPEEGVSIAMLSADIAHLREVFEQDRGQTRAGRLILINEKASKVYHAKLIADMIREEAGERFESRDSIPGHVQQGGTPSPMDRTRAVRLAIKCIEHLEKYEAKTDKEIIADKQSSTVIGIKGAQVVFSNMADVEENETDWPNRRPKDEFWSGVKGAVDILAGRPDVPRPVRRLVGWKAKDVKRGLM
84
B9RSX6
1.11.1.7
ACT_SITE 68; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MMARDGILIAISSLLVLAAVGVSNADGLSLRFYNTSCPDAELIVRNITRNRAQSDSALGAKLLRMHFHDCFVRGCDASILLDAVGIQSEKDTIPNQSLSGFDVIDEIKTQLEQVCPGVVSCADILALASRDAVSLSFQKPLWDVLTGRRDGTVSLASEVNGNIPSPFADFNTLMQQFSNKGLDVNDLVVLSGGHTIGVAHCATFTNRLYNFTGIGDMDPSLDKTYAELLKTKCPNPSNPATTVEMDPQSSLTFDKNYYDILLQNKGLFQSDAALLENTQSARIVRQLKTSNAFFAKFAISMKKMGAIEVLTGNAGQIRQNCRVVNP
14
Q8DRP3
3.5.4.33
ACT_SITE 59; /note="Proton donor"; /evidence="ECO:0000256|HAMAP-Rule:MF_00972"
MYYTLEEKEVFMREALREAEIALEHDEIPIGCVIVKDGEIIGRGHNAREELQRAVMHAEIMAIEDANLSEESWRLLDCTLFVTIEPCVMCSGAIGLARIPNVVYGAKNQKFGAAGSLYDILTDERLNHRVEVETGILEDECAAIMQDFFRNRRKK
186
W1PTM9
2.1.1.37
ACT_SITE 497; /evidence="ECO:0000256|PROSITE-ProRule:PRU01016"
MAAKKGVKRSRAVYGSSIAPSPCPTPLSEIGASEEEEAFLEDEEMEEMEEMEEMEEMGEMLAKKREPQRRKPTTASTSKASSKKARTSDEVPDSRLLGDPVPVSEAQRRWSHRYNKQKDKRGSTSSNGDNGGETALNVKCHYEQCEVDGCIYILNDSAIVKGEEGGEDYIGKIVELFETTDGQRYFTAQWFFKAQDTVIKEEAADFHDKKRVFYSDMKDDNLLDCIISKLHIVQVAPNVDLVAKAASIPPCDYYYDMSYSIPYSTFSNLKSDNLKFNSDSSTISSEAAVDGAEKSDSDGGCSSESYEKSGFSLLDLYSGCGGMSTGLCFGAKLCGVNLVTRWAVDMNKSACDSLKLNHPETEVRNESAEDFLKLLRKWEELCKEYSLIGTEKSRWRLEATDNGYDEESDDDTKLSPGEFEVGKLVGICYGDPSETGKIGLKFKVRWKGYGPSDDTWEPLDGLSNCKERIKEFVRNGYRARILPLPGDVDVICGGPPCQGISGFNRFRNYAEPLNDPKNHQMVVFMDVVDYLKPKYVLMENVGDILKFANGFLGRYALSRLVHMNYQARLGMMAAGCYGLPQFRLRVFLWGAQPTEKLPQYPLPTHDVVVRNHVPVEFDGHLVACDADQSRELQQPLFLGDAISDLPEVTNFETRDEFPYERPPRTEFQKYIRLGKHQMMGECSNGNGSSEKALLYDHQPLQLNEDDYQRVCRIPKKKGANFRDLPGVLVRQDKTVYLDSSVERAYLPSGKPLVPDYAITFVRGRSKKPFGRLWWDVTVPTVVTRAEPHNQAILHPEQDRVLTIRENARLQGFPDYYKLCGSVKDRYIQVGNAVAVPVGRALGHALALAIQKLGSYDEPLMALPPKFPQCLHRVSSSTIDVLEHC
47
Q54PX0
2.7.11.1
ACT_SITE 158; /note="Proton acceptor"; /evidence="ECO:0000250|UniProtKB:P28523, ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MIEINNNHNNGNGKQFPSSQIMPDSKKKSIVKIGEYTLGEKIGRGAFGQVFKGLNGKTGEFVAIKQIDSNKIDESSLQSVKGEVEILHKLRHNNIVKVLGVVEVQAQLNFILEYVENGSLRDVIEKFGPLSEELCIIYLYQMLQGLAYLHSNKVIHRDIKASNILITKEGVIKLADFGVASQIDSESQLRFSVVGTPYWMAPESIEISGCSSASDIWSLGSTMIELLTGNPPYYTLQPMAAMFRIVSDQHPPFPTDISKEFLDYFQQSFKKDPTQRPTAQELLQHPIFFTLQKVPPTLSELQSTLKTLNGGRSRLRTSVNSIDWGSSSSTSGSSTPLSSSSSSSNIKSIVSDEDFNKLQTTIKQQAQTISNLSEEILILKKELKEKPKLEEQQFYKEYFMALAISVKVNQCYQDKTCEPKDMQQLYEMARSQEIPWYKLIEWIPSQLISNDNIPQLTPSSSRENISLSNSSSSIPNPNQNQNQNNKSKSKKFGFFS
99
C5X3C5
1.11.1.7
ACT_SITE 110; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MDAKLAALIALLALLGPVACHGATVICLGGWVRPVPSLLGGLVCPGNLLPNPSLNPIPAPSSSVLKVGYYNNSSNSNACPNAEDIVRKVVEDAVSKDPGTGAGLIRLFFHDCFVRGCDASVLLRNTSGGSTSEQTEMFGLPNVNSLRGFEVIDAAKAALESACPGVVSCADTLAFAARDASSVLSGGRISSAFAMPAGRLDGRVSLANETTDNLPGPFCDLDALTNFFAAKGLDRDDMVTLSGAHTIGQARCAFVSNRTDMNATLAKDLRRDKCRSGGNTKVALDYKTPDTMDVQYYQNVNDDDVVLDSDAALSSPATKPLVDTYAAGSSLSLWETKFAAAMVKMGSIEVKTSPGADAEIRKKCSIYN
14
O22040
2.7.11.25
ACT_SITE 197; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MQDFFGSVRRSLVFRPSSDDDNQENQPPFPGVLADKITSCIRKSKIFIKPSFSPPPPANTVDMAPPISWRKGQLIGRGAFGTVYMGMNLDSGELLAVKQVLIAANFASKEKTQAHIQELEEEVKLLKNLSHPNIVRYLGTVREDDTLNILLEFVPGGSISSLLEKFGPFPESVVRTYTRQLLLGLEYLHNHAIMHRDIKGANILVDNKGCIKLADFGASKQVAELATMTGAKSMKGTPYWMAPEVILQTGHSFSADIWSVGCTVIEMVTGKAPWSQQYKEVAAIFFIGTTKSHPPIPDTLSSDAKDFLLKCLQEVPNLRPTASELLKHPFVMGKHKESASTDLGSVLNNLSTPLPLQINNTKSTPDSTCDDVGDMCNFGSLNYSLVDPVKSIQNKNLWQQNDNGGDEDDMCLIDDENFLTFDGEMSSTLEKDCHLKKSCDDISDMSIALKSKFDESPGNGEKESTMSMECDQPSYSEDDDELTESKIKAFLDEKAADLKKLQTPLYEEFYNSLITFSPSCMESNLSNSKREDTARGFLKLPPKSRSPSRGPLGGSPSRATDATSCSKSPGSGGSRELNINNGGDEASQDGVSARVTDWRGLVVDTKQELSQCVALSEIEKKWKEELDQELERKRQEIMRQAGLGSSPRDRGMSRQREKSRFASPGK
105
A0A2I4EGC8
3.2.1.14
ACT_SITE 94; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001060-1"
MKLFSLILLFSFLLEASAQSGNRTPNPTPSTDGGDVSSIISSSLFDQLLKYKNEFYTYNDFIAATRSFNDFGTTGDVNTRKREIAAFLGQTSHETRGGWPNATDGPYAWGYFFVKENNTTDYCTPSATWPCAPGKQYYGRGPIQLTHNYNYGQAGNATGYDLLNNPDLVATNATISFKTAIWFWMTTQEKKPSSHDVIIGNWTPSAADKSAGRVPGYGVITNIINGGIECGGHAADESVADRIGFYKRYCDAFEVSTGDNLDCYNQSPFT
158
F2Z6G2
4.1.1.17
ACT_SITE 387; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR600183-50"
MAPHILGPEPVQADSSFLGTRPCPTLSYPASFVDEVSASIDQGLSESEKLIANAMKTRIEAIDLETCSPGSEDSFFVADLGIVYSQFMRWSNCLPRVTPFYAMKCNGDPKVLQLLAALGTGFDCASRNEIQTILDLGVSQDRIIYAHPCKVASYIRYASSVGVEKMVFDNAEELYKCAKYHPTAKLFLRIVTDDSQSLCQFSVKYGAALENTQSLLQLAKDLGLNVAGVSFHVGSGAGDPNAFLDAVRNAKRVFDQGAAIGMHLNTLDVGGGFSDDSFESSAAVLGDALDKYFPEESGVNLMAEPGRFFVSEAFTIASHVIARRIIENQNKAMLYLNDGVYGNMNCILFDHQEPVPKVLTYQGKFMYGERYQKQKSSQDVSVWGPTCDGIDCISKSCQLPVLLDVGDWMYFTSFGAYTVAASTTFNGFNSDCETLYVCSKKEVEQYIKL
195
W5N1L8
3.1.3.48
ACT_SITE 143; /note="Phosphocysteine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR037322-1"
RWWYVLLNNMRNSEFDSSDEEDAAEEQTPLLISWLPLSVVEWSQFLGICALPGCKYKDVRRNLQKDIGELRGQGVEEVFVFCTRGELQKYRVPQLIEVYKQQGLSVHHRPFPDGGTPELEQCCQILEELQYSLQNNRRVVMHCYGGLGRSGLMAACLLLQLSGSMTPDKAIEILRELRGAGAIQTVKQYNFLHDFRERSAAYQATKEVAAERSVSR
149
H2MK46
4.1.1.50
ACT_SITE 72; /note="Schiff-base intermediate with substrate; via pyruvic acid"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 86; /note="Proton donor; for catalytic activity"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 233; /note="Proton acceptor; for processing activity"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 247; /note="Proton acceptor; for processing activity"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"
MMMEDQDNGAHFFEGTEKLLEVWFCRQDDTKGTGDLRSIPRFEWDKLLENVHCLIISVTKTDKQEAYILSESSMFVSKRRFILKTCGTTLLLQALVPLLELAREYCGFDSIENFFYSRKNFMKPAHQEFPHRNFQEEVDFLSQIFPNGAAYCMGRLNSDCWYLFTLDLPEYWENNQADQTLEVLMSDLDPAIMDQFYMKDGVSASDVTRMSGIRDLIPGSVIDATLFNPCGYSMNGMKTDGTYWTIHITPEPEFSYVSFETNLSQTSYDELVRKVVEVFKPGKFVTTLFVNQRSKCRSVFSSNQKLDGYKRLDRQLAQFNDYNFVFSSYTKNRQQNQQS
196
A0E5N5
2.3.2.26
ACT_SITE 871; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
MQGIMKTNTIISIKETKKYANILIYKPGPINSDLKSDEVFLFNYPNNHSFNQKIVKLDPEDYVLVNHTNIQQVGSDLMNMWHLEFGSELTIFRQITFDENSKPITNVNLLRQDIYMKIQNSTRGTIQVDEKCLIKQWIMLIKSALKSEFQLNCENIRLWKHKHFPANQAIKQLEQHNGKFHGQILDENQSVGYYKADLIIIDIQLNGKWQFELLDLKTASLEEFKHVFNKAYKGCGKFYCDKNYCNSNPVFNQLQFEKASLQQFLIESFKEDSIDWSEVCWNSDYELKPIQQIEEDIIQQISKVSIYPNSFGGSFVQDFNGSYESILSHNNHPRLNTTVINEINKVIDFNVLKGWINNLYKTKESSPFKLRSIFIILHFDCFTQIIPEKSNSFLEFVFNLDIQSKNQLSQYLTHLPNQQFQNIIEALIKNLILFIKYQQQLPIQLLLKADIRYLMQQLELLQIFYKSNEKVKRIINEKFIIKEITKLYPRQAELLEFKQFACLNNKSLENYYFTFCLYPWIIPIEFKYQILTMDSNINQRNQGDFIWQQIGLAPSLKLLIDRNDIVNSALEQLSRKGINLKSKLSIVFKGEQGIDQGGLTREFFSILTQKLFDVQFTMFVTRNNNTVLWFNKHHMEMPIKYELIGMLLGLALYNQVLLDVSFPQLVFKKLMNETVQFEDLKELDLDTYKALNLLSQYEKDDIEQAFAFNFSITEYDNWGQPLQVDLIQNGSQIMVTQKNKEQYIKLCTEYYLNQSIQKEFQRFHAGFWKVVDGNGIKLLTGAELQTMILGQKDLNMYELEESTKYDGFDKNSEYIRTFWAYIHSLDEQQKKRFLFFCTGSDRVPVGGLKSLKFVIQKHGENTEQLPSAHTCFNVFLLPQYDCLNKMMEKLNIALENSEGFGLM
65
I1MVE2
3.1.3.48
ACT_SITE 31; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR628472-1"; ACT_SITE 33; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR628472-1"
MATASGMPEQETQVFSGNNDQYPRLDVYVWDMDETLVLLNSLLKSSYAEAFNGLKDVQKGVEIGRTWENLILQICDDYFFYEQIENYNKPFLDALAQYDDGRDLSDYDFNQDELGSPHEDDANNRKLAYRHRVIAQKYLQGLRNILDHETIKLWDELYDKTDEYTDRWLSSARTFLKECSGEDKDAVSSVAFANTSSNSTNSNHVNVLVTSGSIVPSLVKCMLFHLDSLITHGNVYSSWEVGKIQCFRWIKERFNHPNVRFCAIGDGWEECEAAEIMRWPFVKIDPRPGKLHRFPGLTLTTVSHYFSVVYGRPGNENDEE
149
P44997
3.1.3.3
ACT_SITE 109; /note="Nucleophile"; /evidence="ECO:0000250"; ACT_SITE 111; /note="Proton donor"; /evidence="ECO:0000250"
MQIQCFESITQKYPQFPTALLANEEPIQNGEPFILYGTKLDITKLEKFQQKCGQNFQIFDVWMVAKNIIVLLKGQWFSDFIKFTHDVEVDIAKLDFSPKLSQAGLLVMDMDSTAIQIECIDEIAKLAGVGELVSAITESAMRGELDFEQSLRCRVGTLKGAPESILQQVRENLPLMSGLVETIQTLQKYGWKTAIASGGFTYFADYLKALLQLDFAASNQFDIEDGKLTGLVKGDVVDAQYKAKTLQHLLEEYGIDSRHSIAIGDGANDLAMMNVAGLGVAFHAKPKVQPQAQIVVNFADLTALLCLLSANDRI
147
H0YY17
2.7.10.1
ACT_SITE 662; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR620777-50"
MVSWRRRPGPGLAQLWGLCCLVLGCWPAALGCPASCGCSSWRIWCTGSSPGIASFPVPQRSAEGDNVTEIYIANQPNLESINDNEVGFYVGLKNLTVVDSGLRFVSRHAFVKNVNLQYINLSRNKLSSLSKKPFRHLGLSDLILVDNPFKCSCEIMWIKKFQETKFYTETQDLYCIDDNNKKTALLDMKVPNCDLPSANLSNYNITVVEGKSITLYCDTTGGPPPNVSWVVTNLVSNHESDTNKNPASLTIKNVSSMDSGLEISCVAENIVGEDQASAELTVFFAPNITFIESPTPDHHWCIPFTVKGNPKPTLQWFYEGAVLNESEYICTKIHVINQSEYHGCLQLDNPTHLNNGAYTLLAKNDYGEDEKRVDAHFMSVPGDGNGPILDPDVYGPHLMILEMPQITVIKSLQRMFPTVYVVVGIAALVCTGLVITLIILKFGRHSKFGMKGPSSVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVHHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQGKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAGLMAEGNRPAELTQSQMLHIAQQIASGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPKEVYDLMLGCWQREPHMRLNIKEIHSLLQNLAKASPVYLDILG
97
P09394
3.1.4.46
ACT_SITE 36; /note="Proton acceptor"; /evidence="ECO:0000250|UniProtKB:Q8RB32"; ACT_SITE 78; /note="Proton donor"; /evidence="ECO:0000250|UniProtKB:Q8RB32"
MKLTLKNLSMAIMMSTIVMGSSAMAADSNEKIVIAHRGASGYLPEHTLPAKAMAYAQGADYLEQDLVMTKDDNLVVLHDHYLDRVTDVADRFPDRARKDGRYYAIDFTLDEIKSLKFTEGFDIENGKKVQTYPGRFPMGKSDFRVHTFEEEIEFVQGLNHSTGKNIGIYPEIKAPWFHHQEGKDIAAKTLEVLKKYGYTGKDDKVYLQCFDADELKRIKNELEPKMGMELNLVQLIAYTDWNETQQKQPDGSWVNYNYDWMFKPGAMKQVAEYADGIGPDYHMLIEETSQPGNIKLTGMVQDAQQNKLVVHPYTVRSDKLPEYTPDVNQLYDALYNKAGVNGLFTDFPDKAVKFLNKE
156
A0A8I6X2M8
1.11.1.7
ACT_SITE 80; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MAALSRAAMVLTMMGLAATSALSQPSLISMTTDVPLPDGLSYDFHALSCNNLQNMVRDAVQGAIARDAGVVPGLLRLFFHDCFPQGCDASILLTGGNSEQNMGQNVGLRRSVLDLIESIRATVHRACGPTVSCADITSLATKEAVMQSRLPGYDVPLGRRDSLTPATAQQVGILPGPDSNVQQLVRTFADRGFDKMDLVALSGAHTVGKASCGSFRSRAGENADFVRMLQQVCARNPRHLQDLDVATPNTFDNRYYNNLQVGRGVLNSDMALTLDGDTKNWVNNFAGNQGWFFSQFSTSMRKLAHLPGGNIGEIRNNCFRRNGNGDSVVLASEGFAASV
14
A0A1S3XSQ7
1.11.1.7
ACT_SITE 246; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MAAKARIFAGLFLICTILPSLSSAFADHLPEVLLANNSDKNIDVPIHVNNVAHVSDDDDTIFELDGKKGKKLKRALKKRAQKQHDLWEKILDHDIIEESQPEEDAAPVTPTPVPVNPTPTPVPVDPTPNPVPINPTPNPVTVNPTPTNVPAGYPGATLPPVTIGYGGAPQTPNPSATQTPVPVQPAPGQKHPTPEEIKELRKHARLKVGFYDEICPKAEKIIKDGMIRAFGNDSSIAAAIPRLLLHDCFVNGCDASLLLDQTPSGARVEKLANSNGPTVRGFDLIDQIKAELEAECPRVVSCTDLLVYLSRDAFVVSGVPHYDVPGGRRDGMESLEANVHGNLPLPDNTVDTLIDLFKRKGLNEEDLAVLIGAHSIGVAHCFSFLYRLDNPQKAAMVDPRLAGVMRFTCTNQMNTLAFDTTTQYKMDSIYYKQLAEKRGLLESDVLLSEDPRTKDYIQKFGDDQSGWFNKLGKAMNKLASMQVLTGDQGQIRKQCRAVN
14
I1K8L0
1.11.1.7
ACT_SITE 68; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
METRTGTLSITVCSLVMFSFVSLVKGSLSFNFYAASCPSAESIIRNIVSSSSSTDPTIPGKLLRLVFHDCFVEGCDASLMLQGNNTEQSDPGNRSVGGFTVIDSAKRILEKFCPGTVSCADIIALAARDAVEIAGGPRTMIPTGRRDGMVSVASNVRPNIVDTSFSMDEMVKLFASKGLSLLDLVILSGAHTIGTAHCSSFRDRFQEDSKGKLRLIDKTLNSDYANELIKQCPAGVQPSVTVNNDPETSMAFDNMYYQNLLAHKGLFQSDSVLISNDSTRKLVVDFANDQELFFENWDQSFLKLTSVGVKTGDKGEIRISCASTNA
14
A0A2K3CVA1
5.1.3.15
ACT_SITE 204; /evidence="ECO:0000256|PIRSR:PIRSR016020-1"; ACT_SITE 302; /evidence="ECO:0000256|PIRSR:PIRSR016020-1"
MALRSVAMRGQARPSVSAARRSAVSAHRAVNVVASSVADLNKKHGIPGSVEFKEGKSGSPVVVLKHACGASAEMYLFGACVTSWKQPSGDEVLYVRPDAVFDKSKPISGGVPHCFPQFGPGAMQQHGFARNLDWAVSTTSADPNPDEKDPSVEVVLTESDYTLKMWPHKFKAVYTVSLHGEQLNLQLRVINTDDKPFDFTAALHTYIEVLEIAKAKVTGLKGLTYLCKAVDPKVPETKKEDRDAVTFTGYTDSVYLNSPAHVELEVGTGAAVALDSTGWEDTVVWNPHLTMKDCYQHFCCVENAKFGKAATVKPGESWTATVTMSVVDVSN
210
K3ZUL4
1.11.1.7
ACT_SITE 103; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MRTPPPAISPFLAVSALLLLLFATSVAANGYGGGDGASSGPKGNGEQEGVYHIPAYEKPVKGLDAGFYRKSCPEMEGIVQKAVRKAIRDDYTLAASLIRLFFHDFAVQGVDASVLIDEPKKSEKYAEASRTLRGFDLIEKIKKEMESKCHATVSCADILTAAARDAATAVGVPYWPLRYGRRDGKNSIAAEADLHVPMGGKSVTDLVRFFESKGLTIFDLVVLSGAHTIGRATCGAVKPGLCKRKDKPALLDRRYGDFLRRKCGAGGDGEYVELDGETPTAFDNQYYKNLMHGRGVLDTDQKLLLDSRTGDHVRAFANQPSQLFVHQFARSMRKIGEALVRTGNEGEVRRKCSAFNY
14
Q8A6N4
6.3.4.4
ACT_SITE 13; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00011"; ACT_SITE 41; /note="Proton donor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00011"
MKVDVLLGLQWGDEGKGKVVDVLTPKYDVVARFQGGPNAGHTLEFEGQKYVLRSIPSGIFQGDKVNIIGNGVVLDPALFKAEAEALEASGHPLKERLHISKKAHLILPTHRILDAAYEAAKGDAKVGTTGKGIGPTYTDKVSRNGVRVGDILHNFEQKYGAAKARHEQILKSLNYEYDLTELEKAWMEGIEYLKQFHFVDSEHEVNNYLKDGKSVLCEGAQGTMLDIDFGSYPFVTSSNTVCAGACTGLGVAPNRIGEVFGIFKAYCTRVGAGPFPTELFDETGDKMCTLGHEFGSVTGRKRRCGWIDLVALKYSVMINGVTKLIMMKSDVLDTFDTIKACVAYKVDGEEIDYFPYDITEGVEPVYAELPGWKTDMTKMQSEDEFPEEFNAYLTFLEEQLGVEIKIVSVGPDRAQTIERYTEE
253
Q9USJ4
3.1.1.5
ACT_SITE 1044; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"; ACT_SITE 1163; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"
MDITDRILQNRIVSKVIFFVLRSVTLSLVSVTRFSLFLLSFATITVPKWAYKIVTYSLTIQFNFKSLLFLFFVSICVVILVVRYRYLNKYARLPHEAPIKEAKLGPDTNIRPSEPRIGFQNYLDEFLSAISIFGYLEKPVFVELARHIRTQRVAEGNTIYLGEQSSFILVVDGCFQVFTAPEKDSAEVVEEAGQPEYRLLTEVSNGAPLSSFFTVLELFTELIPEATSKENPFKSTTSSLRPGSSTTTEAGANNASKPHMPQPKKARIIAKAKIDTTIAVIPANAFHHLVHKFPNSSAQIVQVILTRFQRVTFSTGYEYLGLSDAIFSIEKNFNSLTAYELPNYIRSDIIDDFKKEAMSEHLSQASNESFIVLRSKGAQSRLSNQYFSKAFDKEHGNFVSDIDRSTANAGDLLSSTNPHSTLLSTSVGPLRKFPLNRSYSREVGDYDISASFRDGLLQCIFKSLGVFNYELKEDNDDLCTENDSSEGDSDSLKKVDFLGQIAMMSATDREEVKSSIVVSTKKSTILEFAKEIEIIFYKKGTTIVRQGDHADGLYYIIDGFLDATCPSKLTFSTSYDTDLGMHSFMIKPGGIVNYQACVSNYRSFINVTARSDVLVGFLPRSCLERIIDQEPLISLTIAKRLISLVPSLLLKLDFAVGWIHLNPDQVVYEKNDPSDCVYVVLNGRLRSIEDERGSARTQVDYFNEYGKGDSVGELEMLLNNRRSSTLFAIRDSELAKIPETLFNALSLSHPAVGLQLSKIIANRMNLLLNNKSMDGMQHQPHEKHSIRTLAIVPSSSTGLLILFSQKLTSVLSVMGKSVKVLRQSSVLEHLGKHAFSRMGRFKLSSYLSDLEDKYDILIYVADSGVGSAWLQTCIRQADCIYILAEADQNPNIGEYEQHLIAMKSTARKELVLLHPERFCPSGLTRLWLKERPWVYAHHHVQLRIGLDNEISQNNEAKVFLNIIRAKVQNLHYGFRKYIDWKHLHPVYQANRAQDSDFARLARRICGKAIALVLGGGGARGISQIGILYALEEAGIPFDIIGGTSIGAFNGGLYAWEADLVPMFGRAKKFCGRMANLWRFVLDVTYPQAAYTTGHEFNRGIWKTFGEIHIEDFWLPFYANTTNITHSRMDIHSSGYAWRYIRASMSLAGLVPPMLSDSGDMLLDGGYMDNLTVSHMQSLGASSIFAIDVGSEDSREPMHYGDTVSGVWALISRWIPFIPKTSFPSLAEIQSRLTYVTSVATGEKVKSMPGCFYMRPPVKDFPTLEFGSFEKIYNVGYNYGKEYVEKLKTSHKLDDILSPRDTSKRHPKFLSSRRNSL
131
D6W9J7
2.3.1.286
ACT_SITE 133; /note="Proton acceptor"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00236"
MSCNYADGLSPYEHKGVLGAPERFDPPERVQEKCEMLADWIRNARHVVLHTGAGISTSAGIPDFRGPNGVWTLEKQGKKPNIDISFKDAIPTKTHMAIKKLVEENYVHYIISQNIDGLHLRSGITRKYIAELHGNMFVEQCNFCDSQFVRNLPTATVGKKCLEINCKRILRGRPCRGKLCDTILDWEHNLPEKDLEMSDYHSSVADLNICLGTTLQIVPSGNLPLRCKKFGGKVVIINLQPTKHDKKADLIINTYVDDVLEKVMKRLGLEIVEYCEKGDPTMNPLEGLNWNITKCNIKEVKALYDLYCKKTKKRKLEMKKQRDSKTKKEEKTEIIDLM
58
A0A1L8G4Y4
2.7.10.1
ACT_SITE 789; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000666-1"
MSFWWIYLALLTLAFSHNTQALRTYPSNEVLTSDALHPCVQSSCSVTLLDSMSAIGDLGWVAYPPDGWEEISVMDERNTPMRTYQVCNVLEVSQNNWLRTSWIPRGNAQRVYIEIKFTLRDCNSLPGVSGTCKETFNMYYYESNNSNLKFIKENQYVKIDTIAADESFTQVDVGDRVMKLNTEVRDISNLYKKGFYLAFQDVGACIALVSVRVFYKKCPMTIRNLALFPDTVTGGDSALVEVKGSCVNNSVEFDVPKMYCSADGGWLVPIGRCACKPGYEEKREACIPCRPGFYKALLTDTYCTKCPPRSSSLQDSAAECACDKNFYRAESDPKSAACTKPPSAPDNPVITVNETSVIMDWSPPDNTGGRLDVSYNIHCRRCYAEMQKCSPCGSGIHYIPRQFGLDLPRVLITDLLPYTNYTFDIEAVNGVSELSSGPKQFISVNVTTSQVVNVILKERKSKDSVTLAFQAPEKSSDMVVEYEVIYYEKYQKDQNYTVLKTRSSSMTVDGLKPGTIYIFRVKAHTLGGQGIYGGEIELETSTEDMVAIADVGHITILAITVAGGLILLIFLVTCFFLSGRSVYMRSCCGSNPPHPDPKKNRGYEPLKIHCGYIKAKQDPDEDKMQFQHGRVKLPGSRTYIHPHTYEDPNQAVRDFAKEIDASAIGIERVIGAGEFGEVCSGHLRLPSKRDICVAIKSLKAGYSEKQRRDFLGEASIMGQFDHPNIIRLEGVVTKCKPVMIITEFMENGSLDTFLKKHDGQFTVIQLVGMLRGIASGMKYLSDMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVISYGERPYWEMSNQDVIKAIDEGYRLPPPMDCPVVLHQLMLDCWQKCRSDRPKFGQIVNILDKYIRSPSCLNELANSSTWQDPSMHDSLPVTTVEQWLEAIKMSQYIDNFTMAGYVTLESVLYLSSNELSKMGIALAGHQKKILASTQNLQVLGTHLQI
97
Q0UQJ0
1.1.1.37
ACT_SITE 200; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000102-1"
MFAARQAFSQASRRAFSSSARQSSKVTVLGAAGGIGQPLSLLLKLNPRVTKLSLYDIRLAPGVAADIGHINTKSEVTGHEATPSGLADALKGAEIVVIPAGVPRKPGMTRDDLFNTNASIVRDLAKAAAEHAPEANILIISNPVNSTVPITAEIFKSKGVYNPKRLFGVTTLDVVRASRFISQLKNTDPSSENITVVGGHSGATIVPLLSQSGYNLEGEKLDSYVNRVQFGGDEVVKAKDGAGSATLSMAMAGARFAESLLKAAQGQKNVIEPTFVDSPLYKDQGCEYFASNVELGPNGVEKIHPVGKITDYEQKLLDACLADLAKNIKKGVEFVKQNP
5
A0A1S3ZRV9
3.2.1.14
ACT_SITE 74; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001060-1"
PPPTPSQDITEIISSNLFDELLLHRNNVACPARGFYTYDAFVQAARNFIGFGTTGNTTDRKREVAAFLAQTSHETTGGWDTAPDGPYAWGYCFKAEVGNPDDMPSYCEPNVEWPCAPGKKYYGRGPIQISYNYNYGPCGVAIGENLLGDPDLVAANTVISFETALWFWMTPQPPKPSSHDVILGIWEPTPSDIAANRLPGYGVITNIINGGLECGHGPDKRVQSRIGFYLRYCQILDVSPGENLDCSDQRSFADGLLFNSM
158
A0A8U0WPL4
1.1.1.37
ACT_SITE 193; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000102-1"
MQQPIPWEKVNRTEPLHVLITGAAGQIGYNLCFLIGRGFLFDCDVILHLYDLNDMALKGLSMELTDCCLPKLKGIISTTEIALAFSNVDVAIIVAGVPRKPGMQRSDLINVNKKVMEMNGKALGTYSNKDVRVVVVANPANTNAYVICKTSGIPPEHITALTRLDQNRATAFVANEVGCQPEFVHNIIVWGNHSNTMQPDLSYSYLADQNGIKPLANCIEDFDAFTEKVRCRGEEVISTRKASSAGSAAHAICQHIKDWIYGTKPGIMVSMGVSSNGEYGIDTGLFYSMPVTCSEGEYHIVDSLVIEPRIKDSLILSELELIDERNIVN
5
Q7S8J1
3.1.1.5
ACT_SITE 1245; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"; ACT_SITE 1363; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"
MESLSNLGNAMSSVLSETTSTTATAILADPTEALSSVVALASDAVSKATSDVVPEHTPTSWFTIILWLLHRISSVLYFVIKLTTITTPTFLFNIFSTSLTVTMNATTLVLIMLFMMAGVTWVVRYRYLNMYSRLPPEPQRKEPAVDLFPETQEEGVKSGLASYFDEFLSAIKIFGYLERPVFHELTRSMQTRKLIAGETLNLEEEQGFCLVVDGMVEIFVKSARDGRRSSSGPSFESDDEEGFAPGRQRYQLLTEVRNGAPMSSLFSIMSLFTEDIQMHDTDDDDSPDPTPSAPGTAMPGYPMNANFQQSNDTLPSIPGTPLSDNHVMQRGMASAESLTMSPLAHDSSRIPSLSLVNTRPAVPRRPVPKRLNTTSAHPDIIARATVDTTIAIIPASAFRRLIKIYPKATAHIVHVILSRFQRVTLATAYNYLGLSGEVLQMERNILKHTVRQLPNHLRGDALDRLKEKFKRERERIGEKEVEKGIALHNAHAARRRRSAASLRKEVALQAYSKRRQSIVTATPAFGTRRERPSPDMPSPGDLLTNTQQLKSGPASQLDLARDATSPRPQRNLSPFSTPRNAHVSLDTREALDEDDMFRESVLECMFRAIGLTGNGSVNPDSTQASPRFVPTDQRRSRGGPGHTAFGFMDAFDPFDNDTESVTSCGFSSSSPVPNPQLLAHDMKDEVEIVFFPKGSVLVEQGERNPGLYYVIDGFLDICVPGDDSSHDLLQSSAKVDHGHDSATGADAFGANSSRFPEPNMNNNFGAEQKKGKQGRRSVALIKPGGLAGYVGTISSYRSFIDVVARTDVCVGFLPLASIDRIVDRYPIVMLTMAKRLTELLPRLLLHIDFALEWVQVNSGQVLFREGDESEAIYLVLNGRLRLVEDQKDGGMNVKAEFGQGESIGELEVLTESARTGTLHAIRETELVKFPRTLFNSLAQEHPNITIKISKIIAARMRAFIDDPSRMGLKDNVVRSYKSSSTLNLRTVAILPVTAGVPVVEFGNRLMNALSQVGPPNGATCLNQAAILNHLGKLAFNRMGKLKLSQYLADLEEKYGLVVYVADTNVNTPWTQTCITQADCLLFVGLADSSPEIGEYERFMLGMKSTARKILVLVHQERYSNPGLTRQWLKNRMWINGGHFHVQMAYTSNTVPIHPPTKRFGPSLKQRVQILQAEIQKYTSRKVRHVPFYSPDAPFKGDFHRLARRLCGKSVGLVLGGGGARGIAHVGIIRAMEEAGIPIDMVGGTSIGAFIGGLYARHADVVPIFGLAKKFAGRMASMWRFAFDLTYPSASYTTGHEFNRGIFKTFGKTQIEDFWLEYYCNTTNISKSRVEFHTSGYAWRYIRASMSLAGLLPPLCDEGSMLLDGGYIDNLTVSRMKSLGSDVIFAVDVGSLDDNTPQAFGDSLSGVWAFFNRWNPFSSVPNPPTLAEIQARLAYVSSVGELERAKTMPGCIYMRPPIDDYGTLDFGKFDEIYGVGYKYGQEFLQKLREQGVLPLVEETEAKKALRRTMAPRRASI
131
Q5A6T5
2.7.12.2
ACT_SITE 374; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MTRTTRIDTQEATKHKDLPPVPSPLSLSSNPNPECLMESKSLGRKNFKKLSLDASPVKSTSGSLRSSDMMSIKEPTSLRQKRQRPPPILHLPTASSSATSTPTSNITGSSSASSIQFAQKSPGSGVIVSQTLSRPSSAGGIPSSGYSSLNVNQSNRNVDPDNVVSTDMILNQISNLDLTSMNHHRQHYQNSHHHLPTTNRKRQTVISSISPTKSSAASSSLEPQIQSLPASSQSPIATTSSLKLNNKDLLTLKQLGSGNSGSVSKILHIPTQKTMAKKIIHIDSKSVIQTQIIRELRILHECHSPYIIEFYGACLNNNNTIVICMEYCNCGSLDKILPLCENKQFPTFVLKKLSFAILSGLTYLYTTHKIIHRDIKPNNVLMTHKGEFKLCDFGVSRELTNSLAMADTFVGTSMYMSPERIQGLDYGVKSDVWSTGLMLIELASGVPVWSEDDNNNDDDEDDEDDAYVRQGSIAAERNGQNSPSRSRKNKQKGNGYNSYNGPEGILDLLQRIVNEDAPTLTNKINPVTKLPYDKYLCQFIDLCLIKDDSVRKTPWQLLEDKEHFFKGVEEGVYDKEHKSWAKKIRKCKV
108
A0A9J7KG07
3.1.3.16
ACT_SITE 152; /note="Phosphocysteine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR620405-1"
MGQVATKVLKPFLPTGCFLGMEEDYEDSIPKTFSVSQMKDVLFAYSHGQYVVPSRHYNEVYKNIFVGDESSARNKHRLMGLGVTHVLNAAEGKSPFMHVQTGPEFYEDVGIDYYGVRASDFEQYNLMQHFEDAAKYIHKAVDEEGGKILVHCREGYSRSPSLVMAYLMIYKEHNVEDALIAVRQKREIGPNTGFLKQLCLFNDKLEAEKQRRMAEEYQAEMEGRNEKGEEESRKEDKTEDSKPEETQDENKEKSKTEANEESRENVQEKDEHVLVS
144
Q9X8I9
3.6.1.1
ACT_SITE 89; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00209"
MEFDVTIEIPKGSRNKYEVDHETGRIRLDRRLFTSTAYPTDYGFVENTLGEDGDPLDALVILDEPTFPGCLIRCRAIGMFRMTDEAGGDDKLLCVPSTDPRVEHLRDIHHVSEFDRLEIQHFFEVYKDLEPGKSVEGADWVGRTEAEAEIERSYKRFKDQGGH
188
A0A2C9VBM5
3.1.1.11
ACT_SITE 387; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MASKFSAIPLLLILFFSLSHARFSPIFTSPETLCNSTPHPSFCKSSLPYNNPGTIHDYAKVSISQSLTNARNFLSLVQYYLTLPSTSYESTIRALEDCQFLAQLNIDSLSYAFETIDNSYDLPGSHSDDLLTLLSATLTNVETCLDGLQSTASASSILKAFSAPLSNGTQCYSVSLSLFRGGWVPKTAEGRLLTERKSINFPNFEKGARKFLPLQSTNGRKLLERFTDGVSVSKMVVVNPYGNGDFATITDAVNSAPNNTGSGDGYFVIYVVAGVYNEYVSIPKNKKYLMMIGDGINQTIITGNRSVVDGWTTFNSSTFAVVGKGFVAVNITFQNTAGAIKHQAVAVRNGADLSAFYNCSFEGYQDTLYTHSLRQFYRDCEIYGTIDYIFGNAAVVFQNCKIYSRLPLSGQFNTVTAQGRTDPNQNTGTSIQNCSILAAEDLASSNGTTKSYLGRPWKEYSRTVVMQSFIDSLIDPSGWAPWSGDFALDTLYYAEFDNTGPGSKTTERVTWPGYHLINATDAANFTVSNFTQGDVWLPATGVPYFDGLL
125
Q8A8S8
2.3.1.181
ACT_SITE 183; /note="Acyl-thioester intermediate"; /evidence="ECO:0000255|HAMAP-Rule:MF_00013"
MKTVLVDWNLIPYAEAWQRQTEWFDTLVRAKAQGEAYENRIIMCEHPHVYTLGRSGKENNMLLNDDQLKAIQATLFHIDRGGDITYHGPGQLVCYPILNLEEFHLGLKEYVHLLEEAVIRVCASYGIEAGRLEKATGVWLEGSTPRARKICAIGVRSSHYVTMHGLALNVNTDLRYFSYIHPCGFIDKGVTSLRQELKHEVPMDEVKQRLECELGRLLNEKKQQIAQ
55
K4A924
6.3.4.4
ACT_SITE 79; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03125"; ACT_SITE 107; /note="Proton donor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03125"; ACT_SITE 207; /evidence="ECO:0000256|PROSITE-ProRule:PRU10134"
MSLSTLSHPAAAAAAAAGSGKSLSPAFPAAQSARLPKTRPHAPAAVSAAAAAAVHADSAEDRVSALSQVSGVLGSQWGDEGKGKLVDVLAPRFDIVARCQGGANAGHTIYNAEGKKFALHLVPSGILHEGTLCVVGNGAVIHVPGFFGEIDGLESNGVRCDGRILVSDRAHLLFDLHQVVDGLREAELENSFIGTTKRGIGPCYSSKVTRNGLRVCDLRHMDTFGDKLDVLFKDAASRFQGFEYSKSMLKEEVERYKRFAERLEPFIADTVHVLNESIQQKKKILVEGGQATMLDIDFGTYPFVTSSSPSAGGICTGLGIAPRVVGDLIGVVKAYTSRVGSGPFPTELFGEEGDRLRKAGMEFGTTTGRPRRCGWLDIVALKYCCQINGFSSLNLTKLDVLSGLSEIKVGVSYNQADGQKLQSFPGDLDTLEQVQVNYEVLPGWQSDISSIRSYNELPQAARLYVERIEELVGVPVHYIGVGPGRDALIYK
253
Q9WXZ5
2.6.1.16
ACT_SITE 2; /note="Nucleophile; for GATase activity"; /evidence="ECO:0000255|HAMAP-Rule:MF_00164"; ACT_SITE 601; /note="For Fru-6P isomerization activity"; /evidence="ECO:0000255|HAMAP-Rule:MF_00164"
MCGIVGMVGENLKLEDLVTSLQKLEYRGYDSAGIAYLGDSFGVYKKKGRIDVLKNGLKQKLNDRFFVGIAHTRWATHGEPNDMNAHPHMDCKEEIAVVHNGIIENYREIREFLEQRGHVFSSETDTEVIAHLVEEEFEGDLLDAVLKAVKKLKGAYAIAVVHKNVPDTIVAARKGSPLVAGIGSGVGILASDVTPLLRFTKDVVFLEDGDVMVLRKDGFEIYNTDGVKQQRRVYHVNWDEKAAEKGGYKHFMYKEIMEDPQALVNALVGRVKNDRPFFEELEYYEELLKNADRIRVVSCGTSYYAGLVFKYFLENHTDIDVEIEVSSEFRYKRPHIKEGDVLIAISQSGETADTLESVRLAKKHGAKIVSIVNVVGSTLDRESDVTLFMNAGPEIGVAATKTYVAELAVLYLLGLKIMEINGYWDREAEEILDKLVRMPELLENVLRKDPQIRELSEKYKDYRNFMYIGRGYGYPTALEGALKLKEITYIHATAYQAGELKHGPIALLDVDFPVFAVMPDDSLFFKTKSNVIESKSRNAPVIVLGTEGNRSLEEITGDIIHVPPTHESLYPLMMAPVIQLFAYHIADLKGLDPDKPRNLAKSVTVE
81
A0A9R1XII7
2.1.1.37
ACT_SITE 480; /evidence="ECO:0000256|PROSITE-ProRule:PRU01016"
MPRAKRRSSSASKDDALVSSEKRPKIEEKKEEDEEVSVVPDLVSPAKSSGGKSEKPKVRSKAKEKVKDEVEDAEESRFVGDPVPAEEARQRWPLRYLQKNKAGKTESLETPKGVEPPKELMQAKRHFTEALVDGRVLFKLGDDGYVQAGEGEDSYICRVVEMFEGVDGTSYFSAQWFYRAKDTIIQACSNLIDDKRVFLSEIRDDNPLDCLLQKLQIVRVPLDADVSEKQAKLGDGDYYYDMSYLVPYSTYQNLPPDAEADGNESDSTISSESDVNGAVNEESQSQNNKRSEMRMLDLYSGCGAMSTGLCLGANMADVNLVTRWAVDLNQYACQSLKLNHPETEVRNESAEDFLQLLKEWEKLCQSYSLVGGGESQQKEEPAVIEEDEEEEDDVDVDNVEIFEVEQILSICYGDPKELKKPGVYLKIRWKGYGPEEDTWEPIEGLSDCHDKIKEFVVNGFKSKLLPLPGDVDVITGGPPCQGISGFNRFRNKDKPLEDEKNKQLVVYMDIVEYLKPRFALMENVVDIVKFAKGFLGRYALGRLVSMNYQARVGLMVAGSYGLPQFRRRMFMWGARPSEKLPQYPLPTHNVVTRGVSPLEFESNTVVHDDGLKVELEKELYLGDAISDLPPVPNDETRDEMPYGGKPKTEFQKFISLKKTDMPGCVASGKEASDHLLYDHRPLKLNDDDYQRVCQIPKKKGANFRDLKGVRVKADNHVEWDPDVERVYLPSGKPLVPDYAMTFVDGRSQKPFGRLWWDETVPTVVTRAEPHNQAILHPLQDRVLTIRENARLQGFPDYYKLLGPIKERYIQVGNAVAVPVARALGYSLGMSCKGNAGGEPVFSLPPKFPNLQPVTSPSVVQENE
47
B8E0W1
4.2.1.11
ACT_SITE 204; /note="Proton donor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00318"; ACT_SITE 336; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00318"
MPAILDVHGREVLDSRGNPTVEAEVYLEDGSVGRAIVPSGASTGSREALELRDNDPKRYKGKGVLQAVKNINEIIAQELIGLEALNQYTVDKTMLELDGTENKSRLGANAILAVSLATARAAAASLGVPLYVYLGGVQARELPTPLMNVINGGKHADNPLDFQEYMIVPLASTFKESLRWAVEVFHTLRSILKSKGLNTNVGDEGGFAPYLEKNEDPLAILVEAIQKAGFEPGKDVALALDLAASEFYEDGKYILKAEGKELTSDEMISLLEYLCDKYPIVSIEDGLSEKDWDGWKKLTDKLGKRVQLVGDDIFVTNPQILAEGIEKGIANAILVKVNQIGSLTETLDTIRIAHQAGYRTVISHRSGETEDTFIADLAVAVNSGQIKTGSLSRTDRIAKYNQLLRIEEDLGEAALYRGILNFKR
200
Q3U4H6
3.2.1.52
ACT_SITE 149; /note="Proton donor"; /evidence="ECO:0000250"
MSSPTPFKMRLVHLDLKGAPPKVSYLSEVFPLFHALGANGLLIEYEDMFPYEGHLRLLRAKHAYSPSEVTEILRLARLSELEVIPLVQTFGHMEFVLKHAAFAHLREVALFPNTLNPHEAESLALVQAMIDQILELHRDVRWLHIGCDEVYYLGEGETSKQWLQQEQNSHAKLCLSHMQAVASHVLTQHPGVTPLVWDDMLRDIPQEQLKASGVPQLVEPVLWDYGADLDVHGKVFLIGKYQECGFQRLWAASAFKGATGASQALPPVEHHIRNHELWLQVAGSGPKDALQGIILTGWQRYDHFSVLCELLPVGIPSLAACLQSLVHGGFAEDVRLRAERFLGVSSLEIADTVSEGAGSFPGSDIHALVTQISLHLRSSVDTLLERNRYVTGWFSPYHRRRKLVHPVMIQHIQPEALSLLSRWNNLVQQLEVALQPVFYPDTIEEWLEENVLPSLQRLQDLLQDLGEAAARQPPPTSPGWDTGQNP
170
Q83EK2
2.7.7.7
ACT_SITE 157; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR606309-1"
MGNLMRQIVLDTETTGLVPEEGHRIIEIGALEMVNRRLTGNHLHFYINPERSIERDAIEIHGITDSFLIDKPLFKDIATELISFLKGAELIIHNAPFDVGFLNHELKLTGQSFKTLTHYCQVLDTLTIARQKHPGQHNNLDALCRRYHVDNSNRDYHGALLDAELLAQVYLLMTGGQTVLFEQQGFAVASRSVSVRPLGTDRDSLSVIRANAAETEAHRAFLQLLTENGLCLWNDQ
121
A0A8R1Z3M1
3.5.1.98
ACT_SITE 150; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR037913-1"
MSATGAALTQVTQEQSRRRVAYYYDSNIGNYYYGQGHVMKPHRIRMTHHLLLNYGIYRDLEVYRPFPASFDEMTRFHSEEYMTFLKTATPDNLKLYNKQMLKFNVGEDCPLFDGLYEFCQLSSGGSLAAAVKLNKQKADIAINWMGGLHHAKKSEASGFCYTNDIVLGILELLKYHKRVLYVDIDVHHGDGVEEAFYTTDRVMTVSFHKYGEFFPGTGDLKDVGAGKGRYYSLNVPLRDGVTDESYQSIFKPVMTRVMDRFQPSAVVLQCGADSLNGDRLGPFNLTLRGHGECVKFFRSYNIPLMMVGGGGYTPRNVARCWTYETALAVDKDIPDELPYNDYFEYFGPNYRLHIDPSNATNDNSSDYLKKLQENVVQNLEKLTFAPSVQMHPTPDDAILCLNDTSLNQDMANPDVRLHPSIMDGVTQDPGEFYDGETEGDDRRNEHNAKRAAEGGGDDAAKRARNDN
184
Q9HR24
3.5.4.5
ACT_SITE 55; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR606262-1"
MDTDDLLAAARDATAAAHVPYSEYKVGAALDTASGAVYTGCNIENANYSNSLHAEEVAVGKAVSAGDTDFQRLAVTSSQRDAVTPCGMCRQTLAEFAADDLTILCDSGDDTAGVVTYTLGELLPDTITASNLDA
187