Entry stringlengths 6 10 | EC number stringclasses 260
values | Active site stringlengths 0 544 | Sequence stringlengths 20 2.05k | labels int16 1 260 |
|---|---|---|---|---|
A0A1S3WZJ8 | 3.4.19.12 | ACT_SITE 25; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331"; ACT_SITE 134; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331"; ACT_SITE 149; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331" | MISSERVNMEGGTNIYHERQRLQFCLLHSLNNLFQGKDVFTRAELNSIAEKLDIDDPNRGIWNPVSIVFKPHHNAITGNYDINVLIAALEQKGKTVVWHDRRNGASSIVLDDRLMGIVVNVPVRKFGDLWRSRHWVTLRCIQGVWYNLDSDFAAPYAFKDSQEVGEFLDGIIAAGAEVLLVMNDK | 175 |
M4C9A1 | 3.1.1.11 | ACT_SITE 195; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MVRISTLYLIIIISVFSDFFASRTAISKSILQHDADGVKIRATVTVSKNGFGNFSRINDAVAMAPNNSNGDEGFFHIKIMEGEYEEYINIDQNKRYLMMSGAGINRTIITGNHSYEDGWGIDVSATFIASGSHFICKHLTIRNTAGPTKGQALALMCSGDLSVFYNCSIEGYQDTLWVRSGKQFYRECDVYGTIDFIFGNAVVVLQKCNLYARRPSKGNGNEITAQGRTNPKDQSGIVIQGCAIKPTHDLARSNYTVKTYLGRPWKNYSRTIIMQTYIDGFIEPAGWDKSSGEALRTLYFAEYNNYGTGSNTTNRVTWPS... | 125 |
D8TE96 | 3.4.21.92 | ACT_SITE 119; /evidence="ECO:0000256|PROSITE-ProRule:PRU10085"; ACT_SITE 144; /evidence="ECO:0000256|PROSITE-ProRule:PRU10086" | MLSPLRETPIGVPKVSFRISGEEDMVRIDTHCPVHRRQPIPTNRLYRERLLFLGQNMDDEIANQIICIMMYLNGENRSKDIYLYINSPGGAVLAGISVYDMMQFVVPDVHTICVGLAASMGSFILTGGGITKRIALPHARVMIHQPASSFYEGQAGECLMEAEEILKLRDCITSIYARKTGKPLWVVSEDMERDVFMSAREARVYGIIDLVVMDTSPPRPIVSS | 179 |
A0A067G0M2 | 3.1.1.11 | ACT_SITE 172; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | LTKKTVFDAPLLTEKLNTNRTIKVDINGDGDFKSIQDAINAVPKGNPNWIIIHVRKGVYREKVYIPEDKPYIFMRGNGKGKTAIVWSQSATNNKDSATFSVEAPHFIAFGISFKNEAPTGVAFTSQNQSVAAFVGADMNAFYHCAFYSTHNTLFDYKGRHYYHNCYIQGSIDFIFGRGRSIFQNCEIFVIDDKRVKIHGSITAQNREDNTDNSGFVFIEGKVYGTGDVYLGRAKGAYSRVVFAKTYLSRTIVPHGWTNWSYVGSTDNLFQAEYRCHGPGAEAKHRVPWSKQLSDQEAEKFMSIDFVDGKNWLPAWV | 125 |
Q59800 | 1.2.1.12 | ACT_SITE 152; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:P00362" | MTRIAINGFGRIGRNVLRALLERDSDLDVVAVNDLTEPATLARLLAYDTTSGRLGRPVTVEGNVLVVDGRRITVTAEREPANLPWAELGVDIVLEATGRFTSAKAARAHLDAGAKKVLVSAPADGADITLAFGVNTDAYDPDLHTIVSNASCTTNALAPLAKVLDDLAGIEHGFMTTVHAYTQEQNLQDGPHRDPRRARAAAVNIVPTTTGAAKAIGLVLPNLDGKLSGDSIRVPVPVGSIVELNTTVARDVTRDEVLDAYRAAAQGPLAGVLEYSEDPLVSSDITGNPASSIFDSELTRVDGRHIKVVAWYDNEWGFSN... | 22 |
A0A3B3H6X0 | 2.7.11.13 | ACT_SITE 384; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000554-1" | MDALTSNGSIMDLASKVVKIKAHFRGDMLITDLPASVTFLQLCAEVKSMCSVAKQQPITLKWIDDEGDPCTISSQMELDEAFRIYSRTRRSGLLLHVFPSIPERPGLPCPGEDKSIYRRGARRWRKLYRVNGHLFQAKRFNRKAYCGHCAERIWGLGTQGYKCITCKLLVHKRCHRLLPQTCQSLMDPVMPSQEPLSDAQSEEVDPPADDTEDADQIPFLPHNCVEEKTEDAETEDIKAVVDGLDGIKLSQGVTLKLSDFELIRVIGRGSYAKVLLVRLKKNEQVFAMKVVKKELVHDDEDIDWVQTEKHVFEQASTNPF... | 100 |
A0A9R0IH99 | 1.1.1.37 | ACT_SITE 232; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000102-1" | MENSQLVEKIGVYLNSELVEKIGVVSVCFILSYLLIKHIWSSVKMEKEPTRVLVTGAAGQIGYALVPMIARGLMLGPEQPVILHLLDIEPAAEALNGVKMELIDAAFPLLKDVIATTDVVEACEGVNIAIMLGGFPRKEGMERKEVMSKNISIYKAQATALELNAADNCKVLVVANPANTNALILKEFAPSIPENNITCLTMLDHNRAIAQIADKLNVHVSDVKNVIIWGNHSSTLYPDVNHATVTSTDGKKLVRELVANDHWVNKELVSRVQQRGAAIIKARKLSSALSAASAACDHVCTWVLGTKKGTWVSMGVYSDG... | 5 |
A7SL27 | 2.7.11.13 | ACT_SITE 507; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000551-50" | MVGFTGSLKLRIFEAIELKPAAKAHWGVKLTTIDPYLLVKVDDVQIAQTTSKTKTFTPVWNEEFIVEVENGRDLEFAVFHNAIMPPKPFIANTTVSLEEVIKSGSSEIWIPLEPHGQVHVNIELKPSNTAHQHYHDKEQRVFKENPGGINRRRGAMRRRIHQINSHKFMATYLRQPTFCSHCNDFIWGVIGKQGYQCQVCTCVVHKRCHKMVVTKCPGTRQDAETMPLGGGSLRFKMDVPHKFEKKSYNRPTFCELCGSLLYGIVRQGMQCTVCKMNVHRRCHQNVANNCGINPKKMAEILEEIGISPDRIHEESQQIKK... | 100 |
P27450 | 2.7.11.1 | ACT_SITE 218; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MGACISFFSSSSPSKTGLHSHATTNNHSNGTEFSSTTGATTNSSVGQQSQFSDISTGIISDSGKLLESPNLKVYNFLDLKTATKNFKPDSMLGQGGFGKVYRGWVDATTLAPSRVGSGMIVAIKRLNSESVQGFAEWRSEVNFLGMLSHRNLVKLLGYCREDKELLLVYEFMPKGSLESHLFRRNDPFPWDLRIKIVIGAARGLAFLHSLQREVIYRDFKASNILLDSNYDAKLSDFGLAKLGPADEKSHVTTRIMGTYGYAAPEYMATGHLYVKSDVFAFGVVLLEIMTGLTAHNTKRPRGQESLVDWLRPELSNKHRV... | 99 |
A0A2C9VTC4 | 3.1.1.11 | ACT_SITE 353; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MELRILLVLTLAPLLFSPPILGYKHVEVKSWCGKTPHPEPCEYFLSQNTKDTPITKESDFLKISMQLALDRALHAEANTYKLGTKCRNEHEKAAWTDCLELYEYVIDWLNQTTTSTCSKFDAQTWLSTALTNLETCRTGFIELGVPDYVLPLMQNNVSKLISNSLAINKVPYTEPSYQGGFPTWVKPGDRKLLQSSSPASQANIVVAQDGSGNYKTIAEAVAAASKRSGTGRYIIYVKAGTYKENIEIGKKLKNIMFVGDGIGKTIVTGSRSVGGGSTTFKSATFAAVGDGFIARDMTFRNTAGPQNHQAVAVRSGSDLS... | 125 |
P00762 | 3.4.21.4 | ACT_SITE 63; /note="Charge relay system"; ACT_SITE 107; /note="Charge relay system"; ACT_SITE 200; /note="Charge relay system" | MSALLILALVGAAVAFPLEDDDKIVGGYTCPEHSVPYQVSLNSGYHFCGGSLINDQWVVSAAHCYKSRIQVRLGEHNINVLEGDEQFINAAKIIKHPNYSSWTLNNDIMLIKLSSPVKLNARVAPVALPSACAPAGTQCLISGWGNTLSNGVNNPDLLQCVDAPVLSQADCEAAYPGEITSSMICVGFLEGGKDSCQGDSGGPVVCNGQLQGIVSWGYGCALPDNPGVYTKVCNFVGWIQDTIAAN | 177 |
W5M2U5 | 2.7.10.1 | ACT_SITE 686; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR620777-50" | MISSWKWRVMARLGFCWILLGLWRFSAACPAVCTCSTSRISCTSIDQEWGIKAFPVLNTDIEMENITEIYIANQSNLHAITDNDVKFYKSLRNLTVTNSGLTYISRLAFQNNVKLQYLNLKDNRLSSLSWRTFRHLNLTSFILSGNPLQCSCGNLWIKLWLGDETESQEIVCWDDKNRNKPLSKLSLPECVLPKVDISLSNVTIHEGKNVILECSATGSPTPLLEWNTDHLVSSYEMVNTSAQRSILKLTNISSHDNGKKIPCSAENIVWGSELSAVLNILFAPKITLLAQAMSDHHWCIPFSVRGNPKPTLHWFYEGAV... | 97 |
Q5NTA4 | 3.2.1.14 | ACT_SITE 142; /note="Proton donor"; /evidence="ECO:0000255|PIRSR:PIRSR001060-1, ECO:0000269|PubMed:28032262" | MQIMATQNSKSNIFWSSSASVVLVLLLLVDVGVCQNCGCNGLCCSQYGYCGSGEAYCGAGCKEGPCSSSSPPSTGTGVGSIVSSDVFNSIVGGAASGCAGNGFYTYDSFISAANAFNGFGTSGSSDVNKREIAAFFANAAHETGGFCYIEEQNPTSIYCDASNTQYPCASGKTYHGRGPLQLSWNYNYGAAGSYIQFDGLNNPEIVGTDSTISFKTAVWFWMVNSNCHTAITSGQGFGATIRAINSMECDGGNAATVASRVNYYQKFCQQLNVDTGSNLQC | 158 |
B9GPA5 | 1.1.1.37 | ACT_SITE 188; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000102-1" | MPKDAVRILVTGAAGQIGYALAPMIARGIMLGPDQPVILHLLDIQPVAESLKGVRMELIDAAFPLLQGILATTDVNEACKGVNIAVMVGGFPCKEGMERRDVMHKNVPIFKAQASALEQHAAPDCKILVVANPANTNALILKEFAPSIPVKNITCLTRLDHNRALSHISERLNVDVRDVKNVIIWGNHSSTQYPDANYAIATTDIGEKSVRELVADDHWIDYEYINSVRERGAEIIKARKLSSALSAASAACDHVHDWIIGTAKGTWVSMGVYSDGSYGIQPDIIYSFPVTCQKGEWSIVQGLKINEFSREKMDTSMKEL... | 5 |
A0A251N535 | 1.11.1.7 | ACT_SITE 62; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MKIIKTSLLAFFFLLPLVLADLRVGFYNATCPQAESIIQQVVQKQFATDSSITGGLLRMHFHDCFVRGCDASILIDSTPKKPSEKSAGPNLTVRGFELIDEAKKRLEAACPSTVSCADIITLATRDSVVLAGGQSYAAPTGRRDGLVSNPNDVNLPGPSFSVSQALQAFTAKGLTLNDMVTLLGAHTVGLVHCNFFQDRLSNFQGTGSPDPSMDPALVAKLSKLCASGNNPTTFLDQNTSSTFDNQYYNQLLLKRGILQIDQELASDRSTTGIVSGFASNGVRFSQSFATAIVKLGSLQVLVGNAGEIRKNCRVFNPK | 14 |
K3YG96 | 2.3.2.26 | ACT_SITE 783; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MATPGAAASEPDHGAPPTAAVQLLLRNIDSRTTVIRARREDTVGSVLDRLGNGVPPRGGELRAVHAGRELPRGATVGELGLPWDATIHVSYRLLSTPHADAWRLASEITAAARVAATATGGQQQPHEAAPLEKLVRRFLDSAGAAQQRRSHSALGPVADHLDIFLRSGAPGVLVQLYHSNDEHRRAVAERAIRCFLCPDAPSGKGIVRAWTAPVLLEFCGSIATGARTGDSLYTALRSMLATVLSDPEWTPERWHGVSWRRVAEQSTRLAGEMAKGIIQEIATAYRSCWSRPAAATRNLVEFKAFWSVLRRQVLELDDDR... | 65 |
B9GYH1 | 1.11.1.7 | ACT_SITE 144; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MKCSFSFGFLLILVLPLILASAQDGKYERAAYHDNYEGAVQKDQDYEGQYQDQEKGPAKYDKNYEKERTPAQNDQHYDQEEQDYHVPSLEISTLLDNLPSDDLLSFGYYSKSCPKAESIINKHVTKWVEEDRTLAASLLRLHFHDCAVHGCDGSILLNHEGSERTSEASKSLRGFEVIDAIKAEMEKECPRTVSCADILTAASRDATVLLGGPYWDVPYGRKDGKVSIDKDAELVPMGRENITTLIEFYQSNGLNVLDLVVLSGAHTIGRATCGSLQYRLYNYAGTGKQDESLDYRYANFLKRKCRWASEYVDLDATTPR... | 14 |
A0A7I4DXJ3 | 3.1.1.11 | ACT_SITE 290; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MEDFYHNMEPSIGRLQTSAACSGAIHAAGLLRQGWQTLAAAETCPVSSYLLACIKWLHSLRLHASFRSPVLLLHIVAASASSKEPQMGSALGMRCAGLFAFAALAIVGFACADTSEPSQGEFTTWLKYMSDTSDNDAVDDVAPVAEALDSIPLKSTHRTIIHIRAGVYKEKIVINETKHYITFLGDGMNKTVITWNDTAGDFDDQDVLLKTYRSATVGISSEWFIAKGVTFVNTAPSPPAGAILRQAVALRVTGDRAAFYNCSFYGYQDTLYDHRGRHYFENCYIQGSIDFIFGNGRSLYRSCKLHVVADTFGSLTAQKR... | 125 |
I1JBB4 | 3.1.1.11 | ACT_SITE 401; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MKGKVLGSAVSLILVVGVVIGVVAVVQSPKGVNNNNNGGELKTSNRAVTALCQGSDDQKLCHEVLSSSNSTDPKEYIATVVRTSMDSVIKAFNMSDRLTVEHGNSSAGMKMALEDCKDLLQSAIHDLEASGVLVKESSLQDVHQRTAELKNWLGAVVAYQQSCLDGFDTDGEKKVQEQLQSGSLDNVGKLTGLALDVVSGISHILQSLDLNLALKPASRRLLEVDQEGYPTWVSAADRKLLAQLNDGAVLPHATVAKDGSGQFTTVLDAINSYPKKHQGRYIIYVKAGIYDEYITVDKKKPNLFIYGDGPTNTIITGRKN... | 125 |
Q8F9Q1 | 2.1.1.33 | ACT_SITE 123; /evidence="ECO:0000250" | MVQDLEQKLWSIASGIPFSSDYFLQASPIRKLKKENLFSKVFETYFLELGSGWGEVAISMALQRPNTGFILMEKKFDRIRHTIREIEKHSLDNVKILCVNFNWFLEEVFEENLFSEILLNFPDPWPKKRHHKKRTVNSKFLESLKILLPEKGKFYFATDYGPYARKVIRLFRDSKAFSPEKVELKSERNEIPVSHFERKKREEGKRIYYIDRVLVQK | 45 |
A7RN88 | 2.7.10.1 | ACT_SITE 169; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000615-1" | HKLPYDPLWEYPRESNHIKYLLGSGAFGQVYLGETEGGIDYRRPSAISMRGNIKVAIKTLKGGATESEQKDLLSELKILIHVGSHKNIVNLLGACTKGPQRDLWIILEFCANGDLLSYLKKKRDIYDPAWCAPSEDHDVQFTQMELVSAAYQVARGMEFLASRRCIHRDLAARNVLIADDYVLKVADFGLARDVYKNEEYVKHTPGLVPIKWIAIESLTDKIYSQKSDVWSYGVLLWEIFTLGGNPYPDLHPSDVFEYLLDGKRMEKPVDCAQEIYNIMTDCWVLSPEDRPTFTELVKKLDKMI | 97 |
Q7VD64 | 2.2.1.2 | ACT_SITE 135; /note="Schiff-base intermediate with substrate"; /evidence="ECO:0000255|HAMAP-Rule:MF_00492" | MTSLLDQLSSMTVVVADTGDLEAIRTFKPQDATTNPSLILAAAQIPAYQNLIDKSLQASRQRVGSFASAKEVVDEALDEVCVTFGKEILKIIPGRVSTEVDARLSFNTQATINKARKIIDLYKKVDISKERVLIKVASTWEGIKAAEVLESEGIHCNLTLLFGFSQAVACAEAGVTLISPFVGRILDWYKAETGKDSYAGEEDPGVVSVTKIFNYYKSNNYKTEVMGASFRNIDEILELAGCDLLTIAPKFLEQLENSDSKLTRKLDSLKPLPSETKIHLEEYDFRNMLKLDRMATEKLEEGIINFSKAIEQLEQLLSKR... | 52 |
A0A3B6B707 | 3.1.1.11 | ACT_SITE 458; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MTNKAATASIIAAVGVVAVIGTIAAVTTSKKASEDGGNMSTSIKLSQLCSSTLYPAKCENSLTPVVNESSNPEEVLRAALQVAMNEVGAAFAKYSDVGKGATDKITLSAIGECKKLLDDAIVDLKDMAGLRADQVVVQVNDLRVWISGVMTYIYTCADGFDKPELKKAMDKLLTNSTELSSNALAIITRVGQFLHQGQDAKSGSTVGGSRRLLGWYMGDAHDVESRRHLLAINGRLDEIAVVRDASRRLLSETMDEEDQRVLATEVVGTIEDLPNNHRRKLLSAGIFPEWVSSHTRRLLRIPGGLQKPNAVVAADGSGNF... | 125 |
A0A022QP16 | 1.11.1.7 | ACT_SITE 76; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MKMGAGRGMIVGLLMMMVVVVAVEGGSREYEYDDALSYGYYHGNCPQLEGIIHRKLHNWFKNDSTLAPALMRLHFHDCSVRGCDASILLNHKGSERKAKASKTLRGFQVIDDIKSEVERVCPKIVSCADILTAAARDATVAAGGPFWSVPYGRKDGRISLAKEAESVPMGHEKITDLIELFQSKGLNILDLVVLSGAHTIGRTSCDSLQFRLYNYKGTSKPDPTIDPKYLNFLRRKCRWASEYVDLDAVTPKAFDVQYYKNLQKKMGILSTDQMLYSDSRTAPLVSAFASQSSVFHHQFAASMVKLGNIQDFLADQHSEI... | 14 |
Q24488 | 2.7.10.1 | ACT_SITE 539; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028" | MNKYSAFIVCISLVLLFTKKDVGSHNVDSRIYGFQQSSGICHIYNGTICRDVLSNAHVFVSPNLTMNDLEERLKAAYGVIKESKDMNANCRMYALPSLCFSSMPICRTPERTNLLYFANVATNAKQLKNVSIRRKRTKSKDIKNISIFKKKSTIYEDVFSTDISSKYPPTRESENLKRICREECELLENELCQKEYAIAKRHPVIGMVGVEDCQKLPQHKDCLSLGITIEVDKTENCYWEDGSTYRGVANVSASGKPCLRWSWLMKEISDFPELIGQNYCRNPGSVENSPWCFVDSSRERIIELCDIPKCADKIWIAIVG... | 97 |
A0A1W0VY79 | 3.5.1.98 | ACT_SITE 163; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR037913-1" | MDTSGNSLPSPSCPDGKKREVCYYYDAGIASVDYGEDHSMVPRRVDMAHALVRSYGLLHDMRRLRTRPATVTEITGDFHEPDYVRLLQNLTPESFYAGGATMSAAKAHNIGVLKEGETFYDNPPIAGLWDYCQRYAGGSLAAARALGEGKADIAINWSGGMHHACKAAASGFCFVNDIVLAIKDLLHHFRRVLYVDIDVHHGDGVETAFLDSNRVMTVSFHQRTKNFFPEERGHVNHVGEGAGLYRALNVPFMEGVGDEGYCEMFKAIMKRVVDVFQPEAIVMQCGSDSLSGDRLGQLNLSIAGHAQCVSYMRSFNLPLL... | 184 |
A0A067ELN8 | 2.7.1.11 | ACT_SITE 274; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03186" | MDSSSISSTAASFVTLKFRCFDPTYAYSATPNHRRSFVTSSRSLTPCATNSNGSMATTENSERKIITGEAGYVLEDVPHFSDYISDLPTHPNPLQDNPSYSVVKQHFVDVDDSVAQNIVVHQDSPRGRHFRRVGPREKVYFESDDVHACIVTCGGLCPGLNTVIREIVCGLYYMYGVHKVLGIEGGYRGFYARNTIPLTPKIVNGIHKRGGTILGTSRGGHDTSKIVDSIQDRGINQVYVLGGDGTQKGASAIFEEIRRRGLKVAVAGIPKTIDNDIPIIDKSFGFDTAVEEAQRAISAAHVEAESFENGIGVVKLMGRY... | 84 |
A0A1U7ZR74 | 1.11.1.7 | ACT_SITE 110; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MWELAKNLSVFLLAVSVLLSLGYQIGEPKNGLTSSSVTSTPMSHSSLHAFWYHPRVFNPKEFPFIDQPFLEYDFYRNSCPQAEYIIRSTVHQLYKTRSDVAPALLRLVFHDCFVQGCDASILLDASNGVESEKDAPPNETLKGFDLIDVIKSKLEEECPATVSCADILVLAARDGVALAGGPFYPLRTGRRDSILSFRQIAASELPSPHDELAQTLTTFATRGFDERETVTLLGAHSIGMIHCKFFRNRLFSYKGTNGPDPTLEPEFLNLMRSRCNRTGSSEPPSSTTSSEEEPGMDMDYEGTGQGFGTIYYKSLVQRRG... | 14 |
A0A1D8PU67 | 3.4.25.1 | ACT_SITE 30; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR600243-1" | MPGLNFDNYQRNAFLTSKGFATPKATSTGTTIVGCKFKDGVVIAADTRATSGPIVADKNCEKLHRLAPKIWCAGAGTAADTEMVTQLIASNLELHALSQNRQPRVIAALTMLKQHLFKYQGHLGAYLIVAGVDPTGAHLMSVQAHGSTDIGKYQSLGSGSLNAMAVLETNFKEDMTRDEAIKLCSDAILAGVWNDLGSGSNVDVCVMEVGKDAELYRNYITPNVRIKKCKDYKFPRGTTAVLKQSIRDICDVEETVVNFNDNGDNMEVDTQA | 180 |
A0A0K9NJZ3 | 1.11.1.7 | ACT_SITE 63; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MNVLVLVLFLFGSGFHQTHCQRLQRGFYSSSCPDAESIVSQVVKEGTDSDPTLPAALLRLHFHDCFVDGCDGSILIDTSSSNDERHASAHQGVRGFDIVETAKSRLEDACPGVVSCADIVALMARDSVSISRGPKYEVLTGRRDGLVSNSDDASEMPSVDDSVETLTDKFKKKGLSQRDLVLLTGAHTIGKAACFFITDRLYESNAPDLRIVPHFVPELMSMCPKNGVNSVKVSMDRGSDRRFDSQFYANVRGGFGIIKSDAALYGDSNTAEMVENYADNEDSFRNDFVGSILRMGNAGVNTGNSGEIRTTCSSFN | 14 |
Q12013 | 2.3.1.225 | ACT_SITE 476; /note="S-palmitoyl cysteine intermediate"; /evidence="ECO:0000250" | MTSMSIIDDENVKKTSNGAAVVTDVAQHAVSDSDNNKAQLLGDGSNTEYVVDIFIEAAKDGDLKVVKDVVESGAVDINNDRIDELSGLHWACINNRFSVAKFLLLRGANPNQAAGPGGATALHWAARYGNIYIVDLLLKHGADPTLKDEQGLNIMHFSVYSSNILLVVYVLYFVVNNNDNVDIDSKDNNNRTPLLWAAYQGDFLTVELLLKFGSTVAWTDNRGFNALHCALVGGDQRVICDLILSGANFYERNNQKQDCFDLAEGMGTKSLFEQALQHHGYDRLGNQKDKLFKKSSHAQFTIFLSPFLLMVYIYLISLVL... | 57 |
F6I565 | 2.3.2.26 | ACT_SITE 1601; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MRIEVEEAMTANPPMELGMDFMREEMDEGGVLHNTDQIEMTYHVENRADDDMGDEDDDMGDDGEDDEDDDDGEDEDEDIAEDGAGLMSLADTDVEDHDDGGLGDDYNDEMVDEEDDDFHENRVIEVRWREALHGLDHLQVLGQPGAASGLIEVAAEPFEGVNVDDLLSFRRPLGFERRRQTGRTSFERSVTEINGFQHPLLLRPSQSGDLVSMWSSGTNSSRDLEALSAGNFDVAHFYMFDAPVLPYDHMPTSLFGDRLGGAAPPPLTDYSIGMDSFQMVGRRGPGDGRWTDDGQPQGSSQATIIAQAVEEHFISQLRSI... | 65 |
A7EK43 | 1.11.1.6 | ACT_SITE 75; /evidence="ECO:0000256|PIRSR:PIRSR038928-1"; ACT_SITE 147; /evidence="ECO:0000256|PIRSR:PIRSR038928-1" | MSSQKTSGDQYRDYQDDRNAKSQDVVYTTANGVPMPHPYETQRVGENGPLLLQDFHLIDLLSHFDRERIPERVVHAKGGGAHGTYKTTNGLDDLCLADMFQEGKECPITVRFSTVGGESGSHDCARDPRGFSVKFKTDEGNWDLVANNTPVFFLRDPAKFPHFIHTQKRDPSTHLTHADDSTMFWDYLSQNPESVHQVMILMGDRGIPDGWRHMHGYFGHTIKLVNKAGEWVYCQFHMISQQGTKFFTQEESAEKSPDYAQKDLYEAIDKGDFPKWSLEVQTMTAKEAEDLWEKEKINVFDLTHVWPHKQFPLRKVGELT... | 13 |
B8C427 | 3.2.2.27 | ACT_SITE 111; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03166" | MPRSDRDSGANESSDDDEEKGNGTNASTTKKRPEPPTPHSFEEDLAHQLTDLGWQSVLSEHMKSESFKSLMSSIQSDIDAGATIYPPVGDIFSALNMCPLDNIKCVIVGQDPYHQPGQGHGLAFSVRKGVSIPPSLRNIFKEAIDDVGISPPEHGNLEGWARQGVLLLNTVLTVRRGEANSHAKLGWEEFTDFIINSINERNDSVVFMLWGAPAQKKACCVDEAKHAVIKTSHPSPLGATKTAFPFLGSRCFSRANAALIAYGKGPVDWHVR | 173 |
A0A7M7NQH6 | 3.1.1.4 | ACT_SITE 84; /evidence="ECO:0000256|PIRSR:PIRSR601211-1"; ACT_SITE 144; /evidence="ECO:0000256|PIRSR:PIRSR601211-1" | MDRKTLTSLILLVTICLSWAHKSGSSDDGSPVVTRNKRNIAQFASMIKCATGRSGLDYNNYGCHCGIGGGGTPVDATDRCCEAHDKCYDDIIADDSLGILGICSPYVATYKWSDSSCDDSPPTPTCITTGWLNTNCKKRTCQCDKDAADCFRAAQETYDGEKYKGYDKDNCS | 130 |
Q0U2W5 | 3.1.3.16 | ACT_SITE 116; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR033096-1" | MSIGGSDLDKAIQQLRACRPIPENQVRELCYKARELLIEEGNVVGVDAPVTICGDIHGQFHDLMELFRVGGDVPDTNYLFMGDFVDRGFYSLESFLLLLCLKVRYPDRITLIRGNHESRQITTVYGFYDECLRKYGSVNVWRYCCEVFDYLALGALVQGAATSLQPTDGPIAENSNLDSMPDLDQDIEIETLNANGEIMYRYARNSDSQSSVASQASANMGSSSPVAPSPSRVGPAGTGATSSANGSRRNDTGAILCVHGGLSPLVDSVDKIRLLDRKQEVPHEGAMCDLLWSDPDEIDGWGLSPRGAGFLFGADIVKTF... | 144 |
D6WYJ4 | 2.3.2.26 | ACT_SITE 882; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR001569-1, ECO:0000256|PROSITE-ProRule:PRU00104" | MSNAPTSRRNGAQKIRLTILCARNLVRKDLFRLPDPFAKISVDGSGQCHSTEFVKNTLEPKWNSHYDLYIGRNDSITISVWNHRKVIKKQGSGFLGCVRIVNSHIQRLRDTGYQCLDLGKACPADSEPVKGQIIISLLSRDGPCSGTPLAVVGPQGELRGPTDRDSSPSNNDDLPPGWEERRTENGRPYYVNHITRSTQWIKPQSTNKTRRRSTHQNDNNNTNNENTIGGTQMGVQEILNNNTGETLTPSSSTSPVSPVVSPQKTTSTPQTTDNRNNFITLSPTSTSVIPAPNNISCNAPNGENTNVVSPQMGQGQGQRA... | 65 |
C5X746 | 1.11.1.7 | ACT_SITE 82; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MAAAAAATTATTRTAPRPMVAVAVLIVVLCATSVAGQGQLQLQVGYYNKTCPAAEQIVRNETTAAIQASPDLAAALLRLHYHDCFVQGCDASVLLDSTPNNTAEKDSLPNGSLRGFDVVARVKDQLETACPGTVSCADILALMARDAVSLAKGPTWPVALGRRDGRTSSAASCGELPPLHGDIGLMVQAFAAKGLDVKDLAVLSGAHTLGKAHCSSYADRLYASASCATPDPALDARYAARLRMRCPSAGDGNNATAASELDPGSCTTFDTSYYRHVARRRGLLRSDASLLDHRFTRAYVLQVASGRIDGHYFHDFTVSM... | 14 |
A0A1U7ZAQ1 | 3.4.21.89 | ACT_SITE 188; /evidence="ECO:0000256|PIRSR:PIRSR600223-1"; ACT_SITE 238; /evidence="ECO:0000256|PIRSR:PIRSR600223-1" | MGCPRIINFIQRLYPVSDLEGRWRKEMTSLNFFPSTSTSSLKNPRLNSTPSLSTSRNPDCIVASFDPLTRNRYFKQTQLTSFFKNPSFLGFKRFFYPGTRLKRIGCNGARESTEGTKNRSLKVVNSNGGNGDGGGEDGDDGEAENKRGLMPEWLNLTSDDVKTIVTALAVSLAFRTFIAEPRYIPSLSMYPTFDVGDRIVAEKVSYYFRKPCPNDIVIFKSPPVLQEIGYTEEDVFIKRVVAKEGDVVEVHNGKLLVNGVVRNEDFILEPPSYDMTPIQIPANFVFVMGDNRNNSYDSHIWGPLPTKNIIGRSVFRYWPL... | 178 |
Q09815 | 2.7.11.1 | ACT_SITE 644; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MVGLISTSETLPKQESKSSSAPVSNFLSPNNLTEQTCSPLRAHSTFKEPVFLLSQRQYSHNSKILTELINSVKRPNKPDQNEEKSAVGIEEKSFKDEHLAQKKGLHHFADLKEIFLNKNLSTLDGLQDASLHDNIQSGKLDNPVISQNRRIVLEKLANPNSSKEYETIPTVENRHPLNKLSKTKTLAYEETINQLDETPGGTNYPMNKKKTLSSETNKYEYPQQSKFHECSQFASPRSSIVNGPRTLGKNSKRADDTARMASRMKPSNFNNNIQSSSYGHASQSTKLTSQRDNDHQKDLNFSPYKSIPLNNRPYSPMSEI... | 99 |
Q58600 | 2.1.1.37 | ACT_SITE 133; /evidence="ECO:0000255|PROSITE-ProRule:PRU01016" | MVIMLKFIDLFCGCGGFSRGFVEEGFEPLVAIELNEDAAFSYALNFNGQIYEKIRPGEFKLKELKGYVGIYPFKFPFEEEDIKWLKRLGTLNEKTKKLSPVVINDDIREIHAIEIEKFIKNKKVDVIIGGPPCEGYTGANPKREKNPYDRLYKDETGRLVLEYIRIVGDLQPKIFVMENVPGIKEVRGAIIKEFREIGYEDVYFNTLRAEDYGNPSVRRRVFVSNIEINPEKTQPKTVIEAIGDLMYKGRDVPNHEFAALPARFRKRVHKLGWGDAFIYFKGANRRLGNYIRLHPLKLAETVMGKRFFIHPYEDRLLTPR... | 47 |
A0A287A3L1 | 3.1.1.4 | ACT_SITE 83; /evidence="ECO:0000256|PIRSR:PIRSR601211-1"; ACT_SITE 128; /evidence="ECO:0000256|PIRSR:PIRSR601211-1" | MEGDFQQLPPLLCAGTMELPLLCFLVAFAGVIPAQGGILNLNKMIKQVTGKVPFFSYWPYGCHCGIGGRGEPKDATDWCCHAHDCCYSHLKGHGCRTHLDHYRYTFSQGTVQCSDKGSWCERELCACDKGVAFCMKRNLDSYKKHLRYYWRPHCKGQTPVC | 130 |
G1KNH7 | 3.1.3.48 | ACT_SITE 1120; /note="Phosphocysteine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR000934-1" | MPLPFGLKLKRTRRYTVSSKSCLVARIQLLNNEFVEFTLSVESTGQESLEAVAQRLELREITYFSLWYFNKQNLRRWIDLDKPLKKQLDKYALEPTVFFGVVFYVPSVSQLQQEITRYQYYLQLKKDILEGNIPCTFEQAIHLAGLAVQADFGDYDQYESQEFLQRFALFPVGWLQDEKILEEATQKVALLHQKYRGLLPPDAEMLYMQEVERMDGYGEESYPAKDSQGSDIFIGACLDGIFVKHKNGRPPDFLCNHLHSETSFFSNTASFQLSLTSISFFRQEDMETAKYVWRMCVARHKFYRLNKCSLQAHTVTVNPV... | 149 |
A0A1U8P0S6 | 3.1.1.11 | ACT_SITE 397; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MHNPRVSFRAFLLLFPISAFVLVLLSSAVILKKSPKTTQIGRFHVHNHLQRASSACDGTLYTELCVSTISILPDLASKSLPELISATLNRTMHEVRLSSTNITNIEKKLKSYNTLEEAAINDCLELFDNTMAELKVVRSGLGPKGTSVSENYHDLQTFLSAAMTNQQTCLDGFARSSGNVRSIIKKGLHNISHHVSNSLVMLNKVPGVNKSKPEVFPGYGRVKNGFPTWLSWRDRKLLQASLNETKFDLIVAKDGTGNFTNITDAVSAAPNNSDTRFVIYIKAGAYFENVDVDRKKTMLMLVGDGIGKTVVKASRNVVDG... | 125 |
Q92820 | 3.4.19.9 | ACT_SITE 134; /note="Nucleophile"; ACT_SITE 244; /note="Proton donor" | MASPGCLLCVLGLLLCGAASLELSRPHGDTAKKPIIGILMQKCRNKVMKNYGRYYIAASYVKYLESAGARVVPVRLDLTEKDYEILFKSINGILFPGGSVDLRRSDYAKVAKIFYNLSIQSFDDGDYFPVWGTCLGFEELSLLISGECLLTATDTVDVAMPLNFTGGQLHSRMFQNFPTELLLSLAVEPLTANFHKWSLSVKNFTMNEKLKKFFNVLTTNTDGKIEFISTMEGYKYPVYGVQWHPEKAPYEWKNLDGISHAPNAVKTAFYLAEFFVNEARKNNHHFKSESEEEKALIYQFSPIYTGNISSFQQCYIFD | 176 |
Q2FZ50 | 3.1.26.3 | ACT_SITE 63; /evidence="ECO:0000255|HAMAP-Rule:MF_00104"; ACT_SITE 135; /evidence="ECO:0000255|HAMAP-Rule:MF_00104" | MSKQKKSEIVNRFRKRFDTKMTELGFTYQNIDLYQQAFSHSSFINDFNMNRLDHNERLEFLGDAVLELTVSRYLFDKHPNLPEGNLTKMRATIVCEPSLVIFANKIGLNEMILLGKGEEKTGGRTRPSLISDAFEAFIGALYLDQGLDIVWKFAEKVIFPHVEQNELLGVVDFKTQFQEYVHQQNKGDVTYNLIKEEGPAHHRLFTSEVILQGEAIAEGKGKTKKESEQRAAESAYKQLKQIK | 138 |
A0A8J0TVN6 | 2.7.11.30 | ACT_SITE 368; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR037393-1" | MGTCWGTTGVTVLLLSLMAASHSNMRTNVCKWCDNSHPVCDGGICLTNCSLSSYCENPEEICVTIWKEENESLQLSTRCHHPLLLLENFLVPNYNTSLCVMSAMPSVSGRLYTCACTEEQECNDKLIFYNQSNGFSMLHSREVVPVAAISLLPPFLCAVMVTVLFYLYRTQRLSKIPHSWPDKRGHCPEELIEARRTDEYNCRLSSVLISNSPSDMSPMCANSINHNTELLPIELDQRVGKGRFAEVWRAKLRHSAPGHYEMVAVKIFPCQEFSSWKNESRIFADANLKHKNVLQFITTEIRGTSLQKEYWIITTYHAKG... | 106 |
Q74EA4 | 6.2.1.5 | ACT_SITE 247; /note="Tele-phosphohistidine intermediate"; /evidence="ECO:0000256|HAMAP-Rule:MF_01988, ECO:0000256|PIRSR:PIRSR001553-1" | MSILINSDSKIVVQGITGRSGLFHTQQCRDYGTRIVAGVTPGKGGIHIEGIPVFNSVEEAVRYTGANVSMIFVPPPAAADAILEAADAGLELAVCITEGIPVRDMVPVKRILQESRTRLVGPNCPGVITPGECKVGIMPGYIHKPGKIGVVSRSGTLTYEAVKQITEAGLGQSTCVGIGGDPIIGMNFIDVLKLFNEDKNTEAVFMIGEIGGTAEEEAAYWIKENMKKPVASFIAGVTAPPGKRMGHAGAIITGGKGKAEDKIRTLSECGVVVATSPTKMGVAMLEALGKG | 247 |
B3RY31 | 3.1.1.4 | ACT_SITE 40; /evidence="ECO:0000256|PIRSR:PIRSR601211-1"; ACT_SITE 90; /evidence="ECO:0000256|PIRSR:PIRSR601211-1" | MLQCSSKTSGFDLIDYGCFCGIGGKGSHPVDNIDRCCQQHDQCYGRAHSICKAHGTTSYLASYNWQCIAKKAICYDNHSHTCSHIVCRCDAKFSACIQKYIREYRIKYLGYDRTHCY | 130 |
P43704 | 5.6.2.1 | ACT_SITE 337; /note="O-(5'-phospho-DNA)-tyrosine intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01383" | MRLFIAEKPSLARAIADVLPKPHQRGDGFIKCGDNDVVTWCVGHLLEQAEPDAYDPKFKQWRLEHLPIIPEKWQLLPRKEVKKQLSVVEKLIHQADTLVNAGDPDREGQLLVDEVFSYANLSAEKRDKILRCLISDLNPSAVEKAVKKLQPNRNFIPLATSALARARADWLYGINMTRAYTIRGRQTGYDGVLSVGRVQTPVLGLIVRRDLEIEHFQPKDFFEVQAWVNPESKEEKTPEKSTALFSALWQPSKACEDYQDDDGRVLSKGLAEKVVKRITNQPAEVTEYKDVREKETAPLPYSLSALQIDAAKRFGMSAQA... | 221 |
A0A067FHK4 | 3.4.19.12 | ACT_SITE 18; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331"; ACT_SITE 130; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331"; ACT_SITE 145; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331" | MASENCKIYHERQKLQFCLLHSLNNLFQQEGAFTRASLNEIAEKLVLDYPNKQTWTPLSVVFKPHHNALTGNYDINVLIAALEGRGKSVVWHDRRNEASAIDLDGGENCLMGIVINVPVTRYAGLWKSRHWVALRKIDGVWYNLDSDFHAPQCFKDSKEVREFLDYIIGLGGEVLLVKNDKE | 175 |
Q8PBL0 | 1.11.1.6 | ACT_SITE 89; /evidence="ECO:0000256|PIRSR:PIRSR038927-1"; ACT_SITE 162; /evidence="ECO:0000256|PIRSR:PIRSR038927-1" | MAKSPSKPAQIPSVGSSASAHELRGTGDELHQKAGGSHPQLTTNQGIPVGDNQNSLRATPRGPTLLEDFILREKITHFDHERIPERIVHARGSAAHGYFELTKSLSQYTTAKLLTEVGEKTPLFTRFSTVAGGAGSVDTPRDVRGFAVKFYTKEGNWDLVGNNIPVFFIQDAMKFPDLIHAVKMEPDRGFPQAASAHDTFWDFISLTPESMHMIMWAMSDRTIPRSLRMIEGFGIHSFRLLNENGDSTFVKFHWRPKLGLQSTIWDEAVKLAGADPDFQRRDLFEAIQKGDFPEWELGVQLFTEAEAEAFPFDHLDSTKV... | 13 |
Q870Y1 | 5.3.1.8 | ACT_SITE 308; /evidence="ECO:0000250" | MLPVPLIQLQCGVNSYEWGKKGNSSRAAQFAAASLDDNEFKIDEEKPYAELWMGTHPSNPSKDKHTGRTLLELIQDNQALLSPAIAERYQNKLPFLFKVLSIQKALSIQAHPNKKLAEKLHARDPKNYPDDNHKPEMAIAISDFEGLCGFRPLKEIAHFLDNVPALRQLVGEDKAKAFVETVKRNDGNESDEATAENKKVLQSAFGALMASSEADMTAAADKLVQSAKSAGADFTGTAVPSPGGAKLSELVGRLHGQFGADYGLFVLFFLNFVEMKAGEAIYLRADDIHAYISGDIIECMASSDNVVRAGFTPKFKDVDN... | 214 |
A0A3B6D7N7 | 3.1.1.11 | ACT_SITE 430; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MPPPTPRTKRPEAARLLLLTTFLLLLLTFLFAQSAFAADDHHDGGHHARMLLDANADADADAEHAAAVDRHCAGMLHRDVCVSTLAGIQGLARKPLGEVISKVVERAASAVRAAASNCTSYLSRPHRLRLRDRLALSDCQELFGHTLNQLGTAAAELSAGNRSAEDSISGVQTVLSAAMTNQYTCLEGFAGPSASEDGRVRPFIQGRIYHVAHLVSNSLAMVRRLPQRRRGRALSARATRRSAAEAFEGYGPVRRGFPAWVAAADRRRLLQQQGVGVGVPDLVVAKDGSGNFTTVGEAVAAAPNNSDTRYVIHIKAGGYF... | 125 |
Q7NIR1 | 4.2.1.11 | ACT_SITE 204; /note="Proton donor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00318"; ACT_SITE 337; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00318" | MLITSIEAHEILDSRGNPTVEAQVALENGTTGSAIVPSGASTGEKEAVELRDSDPKRYGGKGVLSAVANVNDSIAPEIIGMEVTDQRSIDRKMIEIDGTANKATLGANAILAVSMAVARTAALSLGLPLYRYLGGTNASLLPVPCMNVINGGKHADNTVDFQEFMIAPHNAPNFAEALRMGAETFHALKSILRGKGYSTGVGDEGGFAPDLKSNEEAVEVILLAIEKAGYRPGEDISICLDPATSEMWKDGKYLFFKSDQSTKTSEEMVDLWASWAGQYPIVSLEDGMGENDWEGWKMLTDRIGATVELVGDDLFCTNAK... | 200 |
A0A5F8AMU1 | 2.7.1.11 | ACT_SITE 402; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03184" | MSTVYVEKNAQILVICPLSFHKPNTPCGQEAALPTTGSAPPGPGDQDFPKGPANVRKEGRKGGRGREECWLLSSAPFGFGLCRGLKAALRAPGWQGGVVAAADSKEPPETQSWARRATRAPALAKGHVRPHWMQPRPGPGHILKTTGVWGSAPGLSARGPRYIAQAQKRTAERWPRRAEGARFQLRPRSVLRGGARGGPGAGRAQGARGAGTGTGRGRRRGAGGGSASWARVSAAAMAAVDLEKLRASGAGKAIGVLTSGGDAQGMNAAVRAVTRMGIYVGAKVFLIYEGYEGLVEGGENIQQANWLSVSNIIQLGGTII... | 84 |
E9HY48 | 4.1.1.17 | ACT_SITE 360; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR600183-50" | MVDASADCQLADGTPKIHVLEPGKENWDVIRDVAHSGVQEEAFYVLDVGDIIRKHKEWKLKMPRVAPFYAVKCNDNRTVLETLASLGASFDCASKSEIAKVLDLGVETDRIIFANPAKQVSHIRYASSVNVQAMTFDNESELYKVKEHHPTAKMVLRIRCDAKRVQCPLGIKFGAFPKDAPRLVALAAKLGVDLVGISFHVGSGCDEPEVFERCIVIGRQIFDLAARDYGINMTLLDLGGGYPGNRGSSINSIAAIVNSSLDRHFPEGCGVDIIAEPGRYYVASAFTLATRIHGRRQLTNDDEDADGPRTPANTSYFYYI... | 195 |
B8E1V2 | 3.1.1.11 | ACT_SITE 291; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MEIKNIILLLTLILLLIITGCSAKESNLVFNVTVLNPPSSVVIDNPYTLNLISTQDAFVTVYLNDNIVFENYPIKANSTQSINISFSKSRGNNIRVEVRNRNQEKYEYAYENVLYLPKVDIVVDKNYTGEDGTEINGRKYFKSVLKAMVYITLNQSAYSGRRVYVFIKSGDYYEKVNIMSPNISLIGEDVNTTRIYYDLAAGSPGAGGTSGSASVTIAGSATGFTAENITFENAFDEIANANISSKQAVAVLSQSDKAVFKNCRFIGNQDTLYVRGGIHYFVDCYIEGDVDFIFGDGRAVFEKCVIFSVDRAGITPKGYV... | 125 |
F6TT57 | 3.1.1.4 | ACT_SITE 478; /note="Nucleophile"; /evidence="ECO:0000256|PROSITE-ProRule:PRU01161"; ACT_SITE 612; /note="Proton acceptor"; /evidence="ECO:0000256|PROSITE-ProRule:PRU01161" | MAYFLEKITGIISDPYSVKQIPDMGEYQRSNMADSHGILALHKVNQYFDLVLFPDSKASQRLIFRLFHLPLSKKKEALSVFEKYKEKLLPILQSTEKEFSVSIISKLCNMIRNNNIRSPMHIVVEAGLSDVKMKEGPMNQWLNSQSCENHSTPLNLACELKLKLVVEKLVEAGAVLNKADDYGNNPFHIAVLMDLKEILQILCTVESGVALNTLNKEEMTPLHIACRAKKLHLCKILLQNKADPFVVGKLGLPIHYALKYSSNEIVELLLKDYPSLVTMQCAKHGGLPLHWCKSQDAVNLLLEYKSPVEVRSWAMHLPLH... | 130 |
M4E4J6 | 4.1.1.50 | ACT_SITE 63; /note="Schiff-base intermediate with substrate; via pyruvic acid"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 77; /note="Proton donor; for catalytic activity"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 234; /note="Proton acceptor; for processing activity"; /evidence="ECO:0000256|PIRS... | MAVSGFEGFEKRLELRFSTTNNNPMGLRLIDFESLDQVLNEVQCTVVSAVANHSFDAYVLSESSLFVYPTKIIIKTCGTTQLLKSIRPFIHLARTLSLTLRACRYSRGSFIFPKKQPFPYTSFKDEVVIVEESLPNSLRYRKASVMTPSNNNNPSRAWHVFTASADVEPDEPLVVVEVCMTELDRVNARSFFRRKGDGKNSDAAGKEMTRLSGIDTINANAFICDFAFDPCGYSMNGVDGDRYSTIHVTPEDGFSYASFECGLSLYDDGHGDISEVLTRAIDVFRPDCVSVATTYGGEDYNHEVTKRVERMLAKKLGLTC... | 196 |
A0A0K9PU83 | 1.11.1.7 | ACT_SITE 62; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MICRAVVALLLCFFVVSDTAGLSYNFYQNTCPDAEKIVADIVKNKIFFDFRWSPRLLRLQFHDCFITGCDASILLDATPSGDKVEKEHKSHETLHGFEVVKDVKEELEKKCPGVVSCADIIVFAVREAIVNMGVDHFPVVSGRRDRRASLASNVEPNIPGEYDSVEKSAKLFASKGFSLDEMIILLGSHSTGVAHCPSIEKRLYGEDTDKYPAMTTALKWMLNLQCPAITANSLNENLFVLLTPMSIGRLSNSFYNSLLSNRGILASDQALTEYPPSEKTVKVLAENDSVWKQEFIKAMQKLGTVDVLTGDQGEIRKQCS... | 14 |
Q5ADN9 | 2.3.1.225 | ACT_SITE 168; /note="S-palmitoyl cysteine intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00067" | MATNNNNNNGNPILRSLETSCCFLATLFPKVFCTLVLTWSLYVLLFIIPNYIKSSLNSTILNIIGITLYVLCIISYYKIILIGPGSPLDYPELRINDLNRMINENPYNNNNNDEEPGDLPPESMIIHTMKVNGNQGYRYCTKCSVWKPDRSHHCSSSGKCILKMDHYCPWFSTCIGFHNYKFFIQFLSYVAIYCWFLFIISGKILYNFITEGLFEDEILSLNLVAVLILSFAFAIAVSVFAMFSIYLCCKNLTTIEFQEKRWNYRGQANDERFNYEFDNNGKRKKINTNIFDLGIMENWKSVMGPNWITWILPITVTVTA... | 57 |
B6K2E3 | 2.3.2.26 | ACT_SITE 618; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MTAMNDFTMSLPKLKSLVRQSMGGPPISTKTSGTTGKPHHKGHEMVIGNCFCCGSRLSYPRSVPCFRCTVCLTINDLPSAKTSLIPEHIQRIEPLSVKRLRHLVEKVKREAALGHASDDLEAVSLAHKPLRLWLSHAFRNSVILNKSFQSKEEPGKDHCGFDYDEISEFYRIVYSLHKCYKEDILQASEALLKRPLRYCTSVYDCRYILIFLQNPLLADSSSKNRMFRDSFLKRIFGLLSNLKPDMQYQFVMWFTQGPYKNASVFQQKVELVNSYISVRLSRIYSHAYLGYSYTSDWKINAAAQTLALLFSANNKMNLLD... | 65 |
A0A1U8FXV9 | 3.1.1.11 | ACT_SITE 246; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MLLTSIIFYFHQNCNTSRMKILELSFILMLLTISTSAKRGKYARRDSTLRVANEEKDYLNWINRMSSRNHSVFQEAKNKLEPCKFIKVNKNPKCGDFTTVQKAIDSIPIINSCRVVISVSPGTYREKIEIPATMAYITLEGAGSHKTTIKWDDTADRTGKDGQPMGTYGSATFAVNSPYFIAKNITFKNVAPAPPSGALGKQAVALRISADTAAFINCKFIGAQDTLYDHRGRHYFKNCYIQGSVDFIFGDGLSLYENCHLRAKTKSYGALTAQKRESLLEETGFSFLNCKVTGSGALYLGRAWGTFSRVVFAYTYMDKI... | 125 |
A0A3Q7G4D7 | 2.7.1.11 | ACT_SITE 226; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03186" | MGSLVDSFALHNLNKKIVMGDNGYVFEDVPHLSDYIPSLPTYPNPLKKNPSYSVVNQYFVDEDDTVAQNIVVRKNSPRGIHFRRAGPSQDVYFKADDVNACIVTCGGLCPGLNTVIREIVCGLYSMYGVARVMGIDGGYRGFYSKNTIPLTPNVVNDIHKRGGTILGSSRGGHVTKKIVDSIQDRGINQVYIIGGDGTLKGASLIFEEITRRGLNVVVVGIPKTIDNDIPVIDKSFGFDSAVEEAQRAISAAHVEATSFENGIGVVKLMGRDSGFIAMYASLASRDVDCCLIPESCFYLEGRGGLFEYIEQRLKENGHMV... | 84 |
A9A2A1 | 4.2.1.20 | ACT_SITE 49; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_00131"; ACT_SITE 60; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_00131" | MSKIKEKFAELQTRKEKALISYIMAGFPNEKSTMSVVRGLVKGGVDIIELGFPFSDPLADGPVIQNASTISLEKGTKIDKFFALVKKIRKETDIPLVLMTYTNILYHKGYSKFIAEAKKSGIDGFILPDMSIEESKDYLKAARKNADTIFLISPNTNKTRIQKIAKASSGFLYLVAVYGTTGVKTGIKNYTIDAIKNVKKQTKGKIPVGVGFGVSTPDDVKKYIKAGADGVIVGSAFLKLIEKTPQNKLESKIASFTKSLKKQTLQKK | 202 |
W5N5R8 | 3.4.19.12 | ACT_SITE 14; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331"; ACT_SITE 14; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR633865-1"; ACT_SITE 119; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331"; ACT_SITE 119; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR633865-1"; ACT_SITE 134; /evidence="ECO:0... | MDSIFHEKQEGSLCAQHCLNNLLQGEYFSPVELSSIAQQLDEEERIRMAEGGVTSEEYRTFLQQPSGNMDDSGFFSIQVISKALGVWGLELILFNSPEYQRLMIDPINEKAFICNYKEHWFTVRKLGQQWFNLNSLLTGPELISDTYLALFLAQLQQEGYSIFVINGNLPECDADQILGIMRVEQRQRPRLIGEEVAQSGSGQGLVMDRTLNSNQNLEAVPVDEDEENLRKALALSRQDIEVEDEEADLRRAIQLSMQGTTGNTKLPDPKDENIAHTSTSGQNETLTAEELRKRRQAYFDKQSTQQARATAPQQQESKST... | 175 |
P35885 | 5.6.2.2 | ACT_SITE 127; /note="O-(5'-phospho-DNA)-tyrosine intermediate"; /evidence="ECO:0000255|HAMAP-Rule:MF_01897" | MTTPEGDALAMRVEPVGLETEMQRSYLDYAMSVIVSRALPDVRDGLKPVHRRVLYAMYDGGYRPERGFYKCARVVGDVMGNYHPHGDSSIYDALVRLAQPWSMRMPLVDSNGNFGSPGNDPAAAMRYTECKMAPLSMEMVRDIDEETVDFTDNYDGRSQEPTVLPARFPNLLINGSAGIAVGMATNIPPHNLREVAAGAQWYLENYEASHEELLDALIERIKGPDFPTGALVVGRKGIEEAYRTGRGSITMRAVVEVEEIQNRQCLVVTELPYQTNPDNLAQKIADLVKDGKVGGIADVRDETSSRTGQRLVIVLKRDAV... | 222 |
G7I304 | 2.7.1.11 | ACT_SITE 287; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03186" | MDLSSSSSVYTSFSSLSKTPPSFSLSSSSSSSRQNSLQLLLLRSHLPQRALFLRNPILPPPFSRQNRLPLAPVRVSNQSENDDGFLLEDVPHLTNFLPNLPSYPNPLQTSQAYSIVKNTFVSPEDVVAQTIVVQKNSPRGVHFRRAGPREKVYFKAEEVRACIVTCGGLCPGINTVIREIVFGLKNMYGVEDILGIEEGYKGFYSKNTMRLTPKVVSDIHKLGGTFLRTSRGGHDTHKIVDNIEDRGINQVYIIGGDGTQKGAARIYEEVEKRRLQVAVAGIPKTIDNDIAVIDKSFGFDTAVEEAQRAINAAHVEVNSV... | 84 |
Q8P9V9 | 1.11.1.24 | ACT_SITE 48; /note="Cysteine sulfenic acid (-SOH) intermediate"; /evidence="ECO:0000305|PubMed:19477183, ECO:0000305|PubMed:27594682" | MTDAVLELPAATFDLPLSLSGGTQTTLRAHAGHWLVIYFYPKDSTPGCTTEGLDFNALLPEFDKAGAKILGVSRDSVKSHDNFCAKQGFAFPLVSDGDEALCRAFDVIKEKNMYGKQVLGIERSTFLLSPEGQVVQAWRKVKVAGHADAVLAALKAHAKQ | 12 |
A0A0D1C194 | 3.1.3.1 | ACT_SITE 92; /note="Phosphoserine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR601952-1" | MQLQGLFAQLGALMLVALAASAAPNNGAKWQHKKQPNVIQLISDGFGPASETFARSYLQSSKKLGWNVTMPLDRLLVGEVRTRSTNSLVTDSAASATAYSCGLKSVNAYIGVDSDKKPCGTVLEGAKAKGYNTALVTTSRITHATPASYSAHIDDRDAEDEIASQQIGDYVLGRQVDILWGGGLRHFLPNTTKPGIRTDSRNLVQEAKQRGFHIINNRTDFDALQAGNALKLPSLALFASSHMAYEIDRNATQEPSLKEMALTALNGLRNQDEPYFIMIEGARIDHAAHNNDPIGHIHDILAYNDMVQAVVDWVDANAAA... | 141 |
Q9FHX3 | 2.7.11.1 | ACT_SITE 500; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MNHHHYSLVIFHLILFLSLDFPTLSHRFSPPLQNLTLYGDAFFRDRTISLTQQQPCFPSVTTPPSKPSSSGIGRALYVYPIKFLEPSTNTTASFSCRFSFSIIASPSCPFGDGFAFLITSNADSFVFSNGFLGLPNPDDSFIAVEFDTRFDPVHGDINDNHVGIDVSSIFSVSSVDAISKGFDLKSGKKMMAWIEYSDVLKLIRVWVGYSRVKPTSPVLSTQIDLSGKVKEYMHVGFSASNAGIGSALHIVERWKFRTFGSHSDAIQEEEEEKDEECLVCSGEVSENPKEIHRKGFNFRVTVVGLKIPVWSLLPGLAAIV... | 99 |
A0A9R1XG85 | 3.1.1.11 | ACT_SITE 419; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MTHIKDFLAGILNSGKNINLTNKRKKIFLTAFASILLLSALIGIVVGVKSRNSTTETITVSAAHAVVRSSCSATLYPDLCYSVISSHPGMHKNIKKQKDVIELAVNITTNAVEHNYFHIKKLTTRKGRSQRQIAALHDCLEMVSETLDELHDVMKDLEEYQTKRSLRQHADDLKTLMSSTLTNQETCLDGFSHDTADKNLRRSLKKSNDWVEKMCSNALAMICNMTSIDLANERKLNGRNLKEEVNNVWPEWFSAGDRRLLQSETAVTPDVVVAADGSGDYDTVAAAVEAAPKKSKTRYVIRIKSGVYRENVEVAKSKTN... | 125 |
K7MZI7 | 3.1.1.11 | ACT_SITE 394; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MAFNSLYFRILCVSLVLSFLTSISIADNNHEAVPPETICYSTLDPSYCKSVLANQNGSIYDYCRISVRKSLSQSRKFLNNMYSYLQHPSSYSQPTIRALEDCQFLAELNFEYLSTTRGTVDKASDVLPTSQASDVHTLLSAVLTNQQTCLDGLQTSASDSRVKNDLSSQLSENAKLDSVSLYLFTKAWDSENKTSTSWQHQNERLPLKMPNKVRAIYDSARGQGKKLLQTMDDNESVLVSDIVVVSKDGSGNFITINDAIAAAPNNTAATDGYFIIFIAEGVYQEYVSIAKSKKFLMLIGDGINRTIITGDHNVVDGFTT... | 125 |
Q89NW1 | 1.8.1.4 | ACT_SITE 554; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000350-2" | MAQQIEVKVPDIGDFKDVAVIEVMVKPGETVAVDTSLIMVESDKASMEIPSSHAGIVKEVKVRVGDKVSEGSIILVLETAGAAAAPPPAPASKPAATSSAAAPVPASHSGKADIECEMLVLGAGPGGYSAAFRAADLGMKTVLVERYDTLGGVCLNVGCIPSKALLHTASVVDEVKHLPDHGISFGAPQIDLDKLRGFKDGVIKKLTGGLAGMAKARKVEVVTGVGAFLDPHHLEVVTAGGKKTIKFAKAIIAAGSQAVKLPFLPEDPRIVDSTGALLLKSIPKRMLVIGGGIIGLEMATVYSALGARIDVVEMLDGLMQ... | 36 |
A0A2C9W5Q3 | 1.11.1.7 | ACT_SITE 64; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MGMQLLAFLLLTCMVATMVQGQGTRVGFYSSSCPRVESIVRTTVETHFRSNPTIAPGLLRMHFHDCFVHGCDASILIDGANSEKTAGPNLPLRGFEVIDDAKSKLEAACPGVVSCADILALAARDSVVLTRGPTWPVPTGRRDGRVSLASDTANLPGFTDSIDVQKQKFAALGLNTQDLVTLVGGHTIGATACQFFRYRLYNFSGNGADPSIDPAFVPQLQALCPQNGDASKRIALDTGSSNTFDSTFFSNLRNGRGILESDQKLWTDATTRTFVQRFLGIRGLLGLTFNVEFARSMVKMSNIGVKTGSNGEIRKICTAI... | 14 |
Q7UQ38 | 5.1.3.3 | ACT_SITE 210; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1"; ACT_SITE 349; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1" | MFVASWRDGMNRFNAKWFAGLLMLGCLANPITAQDQMQVEDFDSIELYTLENQSGAKVQITNFGAIVTSIVVPDRDGKLGDVALGYDSVESYINAVDKPYFGAIVGRYGNRIANGEFSLNGETYSLATNNGPNHLHGGVIGFDKVVWDAEPTAVNGKPALKMTYLAKDGEEGYPGNLQVAVTYQWTDENKLIVRYEATTDKATPVNLTQHTYFNLAGEGNGTILDHELMLNASKFTPVDSTLIPTGELRNVEGTPFDFRKAKAIGRDVGMENEQLEFGLGYDHNFVLDSSDKEGDLTLAARVFEPTTGRTMEIHTSEPGI... | 211 |
H2RFJ6 | 2.7.10.1 | ACT_SITE 621; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000615-1" | MALRHSMGRLGLLLLPPQQLGLLLVALASLLLPESAAAGLKLVGVPAKLTVSQGQLVKLNCSVEGMEEPDIQWVKDGAVVQNLDQFIPVSEQHWISFLSLKSVERSDTGQYWCKVDGGEIQISQPVWLTVVGVPLFTVEPKDLAVPPNAPFQLSCKAVGPPEPVTIVWWRGTTKIGGPAPSPFVLNVTGVTQIHSLKCLASSRIATVLLQALPAVPFNITVTKLSSGNTSVAWMPGADGQALLQSCTVQVTQAPGGWEVLAVVVLVPPFTCLLRDLVPATSYSLRVCCASALGPSPYADWVPFQTKGLAPASAPQNLHAI... | 97 |
A0A067FFH2 | 3.2.1.1 | ACT_SITE 220; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR001028-1"; ACT_SITE 245; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001028-1" | MSPLCFLCFLLLSVFPPFTSPSPTILFQGFNWESCNKKGGWYNFLKKRIPDIASAGITHVWLSSTFSLCCSPRLFFHSIIHQAYSHASLAGYMPGRLYDLHASSYGSQNELKSLIQAFNKKGIKCLADIVINHRTAEKKDRRGIWCIFEGGTPDKRLDWGPSFICRDDTTYSDGRGHPDSGEPFGPAPDIDHLNPRVQKELSDWMNWLKTEIGFDGWRFDFVKGYAPSITRLYMKNTMPHFTVAEKWDSLSYRQDGKLDARQDAHRRNLKYWVQAAGRAVTAFDFTTKGILQAAPPGFIGLLPQNAVTFIDNHDTGSTQR... | 157 |
Q81CX0 | 3.4.21.89 | ACT_SITE 38; /evidence="ECO:0000256|PIRSR:PIRSR600223-1"; ACT_SITE 80; /evidence="ECO:0000256|PIRSR:PIRSR600223-1" | MKLFILKYWRNICGYIFIIIGVIFINKSFLFCMVEGISMQPTLNEKDYILVNKVNVCLSSFHHGDVVIIKKEDAPTYYVKRIIGLSGDNIQLKEDEVFINGKKRDESYIHLDMSQVSNRFSNFREIKVPTHKLFVLGDNRNHSKDSRNTLGLIDESNIIGKVEMVFYPFDHIKWIK | 178 |
A7LXS9 | 3.2.1.23 | ACT_SITE 437; /note="Proton donor"; /evidence="ECO:0000250|UniProtKB:P00722"; ACT_SITE 544; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:P00722" | MMIGKLKYLMLGGCLILGSCLALGGCLMLLGACSSSSLVSPRERSDFNADWRFHLGDGLQAAQPGFADNDWRVLDLPHDWAIEGDFSQENPSGTGGGALPGGVGWYRKTFSVDKADAGKIFRIEFDGVYMNSEVFINGVSLGVRPYGYISFSYDLTPYLKWDEPNVLAVRVDNAEQPNSRWYSGCGIYRNVWLSKTGPIHVGGWGTYVTTSSVDEKQAVLNLATTLVNESDTNENVTVCSSLQDAEGREVAETRSSGEAEAGKEVVFTQQLTVKQPQLWDIDTPYLYTLVTKVMRNEECMDRYTTPVGIRTFSLDARKGF... | 163 |
Q89UE2 | 2.7.1.25 | ACT_SITE 537; /note="Phosphoserine intermediate"; /evidence="ECO:0000256|HAMAP-Rule:MF_00065" | MNMIVTPASPATPNGTTRPQVRIVIVGHVDHGKSTLVGRLLHETGSLPDGKLEMLKAVSARRGMPFEWSFLLDALQTERDQGITIDTTQIRFRTNSRDIVLIDAPGHAEFLRNMITGASQADGAVLIIDALEGVRDQTRRHGYLLHLLGVKQVAIVVNKMDRVDFSADRFQAISDEISAHLNGLGVTPTAVIPISARDGDGVATRTDRIGWYKGPTVVEALDQLEPARPLEALALRLPVQAIYKFDDRRIVAGRIESGSLVAGDEIVIMPAGKIAKIKTVESWPATPIAGRQGAGRSVGITLDRELFIERGDIVAHAGSA... | 90 |
Q1L8G6 | 2.3.2.31 | ACT_SITE 531; /evidence="ECO:0000255|PROSITE-ProRule:PRU01221" | MGNTATKFRKALINGDEGLACQLYESNPQFKEALEPNASYGEPYQHNTPLHYASRHAMTRLIRSFLFCKDGNPNKCNVHNETALHLLCMGPQILLGEGALQPRFSRPQEDQQKRAECLQMILQWTGAKLDQGEYERANVNATDNKKSTCLHYAAAAGMKNCVELLVKNAADLFVENEDRETPCDCAEKQHHKDLALSLESQMVFSQVPGAQEIEAEYAALDRREPYEGLKLQDLRRLKDMLIVETADMLQAPLFTAEALLRAHDWDREKLLEDWMSNAEECCQRSGVQMPTPPPSGYNAWDTLPSPRTPRTTRSSVTSPD... | 67 |
A0A022QQW0 | 3.1.1.11 | ACT_SITE 192; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MNLKITSVFILVTLVTFLDSVHVVAENNVIDSPLLIQKIGSNRTIVVDANGQGDFKSVQAAINYVPNRNSKWIVIHIRKGVYREKVTIPRNKPYIFMKGDGKGKTSIVWSKISEKSYDSSTFKLEAQHFIAFGISFKNTALTHTTSHKAVAALVGGDKAAFYECAFFSNHNTLYDYKGTHYYDKCYIQGSVDFIFGQGQAIFHDCEILATNDLRHEIGGSITANYRQNHKERSGFVFINGKVYGIGNVYLGSAKGTHSRQFIQSRVQVPWAGIRPE | 125 |
B7QJ81 | 2.7.10.1 | ACT_SITE 665; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000666-1" | MDLREGNVPSVCHEDGIEGATWVEESFTNFEQGINWRSYVVCDVAYENVNNWLWTPFIERGPAHRIYIELKFSMRDCNLFPGMALSCKETFSLLYYEFDAATREPPPWEPESYRPVDRIAADEGRFTSNAEVIINTEVRSVPVTKKGVYFAFRDQGACLSLIAVKVYYMVCPNVTTSLAHFPETPTASEVTAIVATEGQCVANARVSQAPPRMLCKGDGNWTLPSGGCACLPGFRAVGSSCQKPPRAPQNLSASCVDQSSVTLSWQAPSHQGGREDTTYRVVCDMCSPSVTFSPARQGFNETSVTVTGLRPVTAYRFQVY... | 97 |
A0A1U8AWF3 | 1.11.1.7 | ACT_SITE 76; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MSSFRDFISSQMPTMLYCFICFLAISTMASGSTASLKVGFYSSTCPSAEAIVRKAVTKAISQNPGIGAGLIRMHFHDCFVRGCDASVLLDSTPGNDAEKSHPANNPSLRGFEVIDMAKAHIEAVCPQTVSCADIIAFAARDSAYKLGGINYAVPAGRRDGLISRSADIRANLPPPSFTAKQLEDRFAGKGLSLEEMVTLSGAHSIGVSHCSSFLNRLYNFNATHPQDPSMDPDYAAFLKTRCPPTSTAGSSLDPTVPLDVLTPNRLDNKYYKNLKNHHGLLTSDWTLMSSHSTAWMVRNNAKHPSAWASKFAAAMVHMGY... | 14 |
Q7UWB8 | 2.7.1.23 | ACT_SITE 88; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00361" | MSRSRFRGRITGWYLMASSSGEKLDWCGCGRPPRIVVLGAPDKLNVSSAWKRLRPTIQSHAELIAADFEFTYDFSDKEVDLVIVIGGDGSILQSARQMGENQTPVLGINCGRLGFLAALSPEDFLDAWPKVCQGDFSIIRHLMLEVQLIRDDEVIAQSMALNEAAILNGPPFAILDIDLYADGELATQYRCDGLIVATPVGSTAHNLSAGGPILRRQLQAIVISPISPHTLTYRPLVDSADTRLELAVTEPNESTSIVVDGRILGQLKSGDRVRVHRAPVSFEMLRVPGQNDYRTLREKLGWSGRLALRQL | 89 |
W1PM24 | 1.11.1.7 | ACT_SITE 60; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MALRYFLLPFFFLSLATAQLSFNFYRSTCPNAEFIIKTLVFNKFNKDPSITAALLRMHFHDCFVRGCDASILINSTSNNQAEKDAGPNETVRGYEFIDEIKTQLEKKCPNTVSCADIITAATRDAVALSGGPSYPIPTGRRDGLISNANDVNLPGPSLSVSQAFSFFRAKGFTLKEMVTLLGAHTVGVAHCGFFRGRLFNFQGTGKPDPSMDTALVSKLQKLCGSSSLPTVRDPTAFLDQNTSFRVDNEFYNQVLKKRGILQIDQALGNDRSSVGFVRQFSSDGNGFLKTFVDAMVKMGKLEVLVGNAGEIRKKCGVFNS... | 14 |
F6QNC0 | 2.3.1.48 | ACT_SITE 753; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR602717-51" | MVKLANPLYTEWILEAIQKVKKQKQRPSEERICHAVCASHGLDKKTVSEQLELSVQDGSVLKVTNKGLASYKDPDNPGRFSLVKPGTFPKSAKGARGSCNDLRNVDWNKLLRRAIEGLQEPNGSSLKNIEKYLRSQSDLSSTTNNPVFQQRLRLGAKRAVNNGRLLKDGPQYRVNYGSLEGKGASKYSSAFPSSLPPVSLLPHERDQPRADPIPICSFCLGTKESNREKKPEELLSCADCGSSGHPSCLKFCPELTTNVKALRWQCIECKTCSACRIQGKNAENMLFCDSCDRGFHMECCDPPLSRMPKGMWICQVCRPK... | 61 |
F1LP90 | 2.7.11.1 | ACT_SITE 153; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MGDPAPARQSDFIFLVALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFTDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKKRGEKEETE... | 99 |
Q9HR36 | 3.4.25.1 | ACT_SITE 49; /note="Nucleophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_02113" | MFNPNNGSEFARNRARLDDTPNPYEPEVGSLPEGDRSQAGSDTVNKTGTTIVGLTTQDGVLMASDMRASLGGRVISNKNVQKVEEIQPNAALSISGSVGGAQSFIRSLRAEANLYEARRGEYMSIDALSTMASNLLRGGPFFRVVPILGGVDDDGGHVFSLDPAGSSMSDTYTAQGSGMPYALGVLEQEYSEDLTMADAEQVAAHAVKSASERDTASGNGIHITKITHDGLTTVGHKEFDALL | 180 |
Q4WRD3 | 3.2.1.23 | ACT_SITE 196; /note="Proton donor"; /evidence="ECO:0000255"; ACT_SITE 308; /note="Nucleophile"; /evidence="ECO:0000255" | MAHIYRLLLLLLSNLWFSTAAQNQSETEWPLHDNGLSKVVQWDHYSFQVNGQRIFIFSGEFHYWRIPVPELWRDILEKVKATGFTAFAFYSSWAYHAPNNSTVDFSTGARDITPIFELAKELGMYMIVRPGPYVNAEASAGGFPLWLMTGEYGSLRNDDPRYTAAWTPYFANMSQITSKYQVTDGHNTLVYQIENEYGQQWIGDPKNRNPNKTAVAYMELLEASARENGITVPLTSNDPNMNSKSWGSDWSNAGGNVDVAGLDSYPSCWTCDVSQCTSTNGEYVPYKVIDYYDYFQEVQPTLPSFMPEFQGGSYNPWAGP... | 163 |
A0A0Q3J9U8 | 3.1.1.11 | ACT_SITE 422; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MPPPSQTQAPRRIIRTHQHLEPTTRTTAATFFFFLLLLLPTASSGQPTFPDDAAAVERHCGGMLLHGDVCAATLSAMPPGLSKKPLPEVISYVVSRAADAVRAAASNCTSYLAPERHSQLRVRDRLALADCLELFSHTLTQLATASSELELELSNSSRTAEERVAGVQTVLSAAMTNQFTCLDGFSDPTQTPGGPSPGPGPSDSSPGRVRPYIQGRILHVSHLLSNSLALLRRLPSSSRRRRRRVPNRAGGFPSWISAADRRRLEQQQVAAADATVAKDGSGDYATVGEAVAAAPNNSARRWVIRVKTGGYFENVEVGSE... | 125 |
A2DQ34 | 2.3.2.26 | ACT_SITE 676; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MIDTPSVESLIKGYFEQLTEGCDRIDCEQPECASSTNFHYHFRDPTEAAVRAVELTLNHPHNPCLCGHYSPLNRDKSILTKVSRFDSIVTDIIYNRASQIPDDQSLHNIKEVVSSEINISFILLSNQETLSISNISFDEDKLQDFNLVFQRGYKYFLPFYTDFNLMVKRFIKLPSTDTFSHVRGIILILLFEIYFNKDNYIDTFLPLLDHIIDLPSKSAMLFWSCLQCISTLLTRVVSLCETMLSIYVLKQSMINVVPKPIASLCNFITLLQRASDNSLHHLPNKVFSNSALSTRLNPLKELERYEFSKFSFLSFPSVLS... | 65 |
A0A0Q3P935 | 1.11.1.7 | ACT_SITE 77; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MAWSRAAMPLGMIVVVAALLSLPSALSLPSLISMPTAGKVDLALTDSCRDDIVRNAVQAARSSDIGVTAGLLRISFHDCFPQGCDGSILLTGPNTEQDIRPQNGGLRQTALDLIESIRDKVHRACGWRSVSCTDIMNLATREAVKQSGGPDYTVPTGRLDSLEPAPRTAVEQSLPAPFFDVSQLLENFGRKGMENLDLVALSGAHTIGKASCGSFSNRFGENTAFMQALSKTCRDIPGWRQDLDVTTPNDFDNAYFVNLLQGKGLLTSDMALVNDGRTRWLVEGFAGNHWWFFGQFGTSMSKLAHMQGDQGRNGQIRDNC... | 14 |
F7G4T3 | 3.2.1.35 | ACT_SITE 134; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR038193-1" | MCKLMRWLAMMMLCVLVDTQNFKPTKAPMFQNKPFIVFWNAPTSQCKNRHHVDLNLDTFGIAANSDEALNGDKVTIFYHNVFGYYPHISDSGESFHGGVPQNQSLSNHLSQVQKDINRVLPSKDFQGLAIIDWENWRPQWIRNWDNKVIYREHSINLVRSRHPSWPDSKVKTVAQKEFEKAGKNFMNSTLHLGLKMRSQGLWGYYLYPECYNYNYKNHPHKYTGKCPNIEISRNNQLLWLWKASTALFPSIYLPEILKSSTNVLKFVHHRVREAIRVATVARQDYVLPVFVYSRPFYSYSLIALSQMDLVHTIGESAALG... | 166 |
O51669 | 2.7.1.11 | ACT_SITE 210; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_01981" | MYRIKNENLDFKIDSLGECKQNNPLIDFYASEGSSHFVNEKNKIKFSVYRNEDKGDRYEDVLLEKAGPREKIYFVPRHVKAAITTCGGLCPGFNDVIRSIVRTLWKIYGVRNIYGVKFGYQGLLPESNSPFINLNPDVVDDINKFGGTILGSSRGGIKPVEIVDTLERMNINMIFNIGGDGTQKGSLLIAEEIEKRNLKIAVVGIPKTVDNDFMFVQKSFGFETAVEQAVAAVAGAHFEANSAYNGIGLVKVMGRDSGFIAAHTALSSNDVNFCLIPELDFDIEGPNGFLVHLERRLLEKESLEEIPHAVILIAEGAGQK... | 84 |
A0A1S3ZQF3 | 3.1.1.11 | ACT_SITE 402; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MYNIRHTSTLPLVILASTALVLLTFFLLLGNPNSSSSTAVATRTPHIHVHKNIQIAQSHCEGTLHPELCVSTLSSFPNLHRKSIAEIISSTVKVAVGEVRDSAHNCSDLRRNVPKLEPIEKRALQDCVELLGETIAELRTALTDLSPKKSASKHYNDIQTLLSAAMTNEDTCLDGLFYCTKNNLTRYVEDNLHTIAHHVSNSLAMLNKIKRTSVSSSEEVFPEYGAVKNGFPNWLKRRERALLQTPVSQTKLDLVVAKDGSGNFTTINEALSAAPNSSSTRFVIYIKEGSYFEYVEVDKKKTMIMFVGDGIGKTKIKGNR... | 125 |
A0A1Y1I1J9 | 1.1.1.37 | ACT_SITE 216; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000102-1" | MAASAERIRRLAAHLNPAGHAGQEGTLLMERTRARGASSGFKVAVLGAAGGIGQPLSLLLKTSPLVSTLHLFDVVNTPGVTADLSHINSSAVVRGFVGNDQLPAALDGVDLVVIPAGVPRKPGMTRDDLFNINAGIVQKLCEGIAKHCPRAVVNIISNPVNSTVPIAAEVFKRAGTWDPRKVLGVTALDVVRANTFVAEVIGVNPEIVDVPVVGGHAGVTILPLLSQVTPSFSFSKEETEKLTVRIQDAGTEVVQAKAGTGSATLSMAYAAAKFAEQCLRGLSGETGIVECAYVSSDVTELPFFATKVRLGRSGVEEIHP... | 5 |
Q7NEW2 | 3.4.21.92 | ACT_SITE 100; /note="Nucleophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_00444"; ACT_SITE 125; /evidence="ECO:0000255|HAMAP-Rule:MF_00444" | MPIGIPKVPYRLPGGQSQWIDIFNRLALDRIIFLGREVDDEIANAIIASMLYLDSEDPEKDIFLYINSPGGSVSAGLAIYDTMQHVRADVATMCVGLAASMGSFLLTAGAKGKRTSLPHSRIMIHQPLGGAQGQATDIGIQAKEILYTKDRLNQILSERTGQPLERIERDTDRDFFMSAEDAKQYGLIDQVVQHRPV | 179 |
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