Entry stringlengths 6 10 | EC number stringclasses 260
values | Active site stringlengths 0 544 | Sequence stringlengths 20 2.05k | labels int16 1 260 |
|---|---|---|---|---|
A7F8C8 | 2.3.1.48 | ACT_SITE 394; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR602717-51" | MTGPSQDKDSNVGTPAPKQKSKATIDTLRVGCIAMVQKDGALRRAEILSIKETKSGRQFYCNFDNFNKRLDEWVPAIRIDFTQDVEWPAPEKPKDKSKAAPAGKKTSVGKKKNQKRPAQASKREDSVISESGSNAQPWSEFADSQRQTPDVDGDGDAKLTVALDLDATPEANDPMDVDEAAAEAANAKNEPVQHFSREEEIEKLRTGGSMTQNQAEISRIRNISKVQFGKFDLYPWYFSPYPEVFTQEDLMYICEFCLSYYGDLKSFTRHRHKCTLQHPPGNEIYRDDYVSFFEIDGRRQRTWCRNLCLISKMFLDHKTL... | 61 |
Q57WC8 | 2.7.11.1 | ACT_SITE 209; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR630616-1" | MVIWFSAGDGVGFPTPTPWEIQPPRGLTSADGCRGGLRDGGEPAVISRQQRQQKPSRHQQQHHCVRQPKPKVVIQQSDLRDEQFQRLSVLGEGSYSVVVAARHLPSRQVVALKELSRQRLRDAKLETQLQWEINLHRTLRHPNIVRLLSYYITPRSVVLVLELCRGGSLLRRLQATAERRFDEGRATRYIRHVAQALAYLHEHGIVHRDLKPGNILVDARGVARLADFGWSKGLAGSAAAAVITNGYDASEVAPRCAAGETDACSETEDGHGRLTVCGTLDYMPPELLGGTPCSYKADMWSLGALLVEILSGQPPFYRTS... | 99 |
A0A059BG26 | 3.4.21.92 | ACT_SITE 144; /evidence="ECO:0000256|PROSITE-ProRule:PRU10085"; ACT_SITE 169; /evidence="ECO:0000256|PROSITE-ProRule:PRU10086" | MAMAMLKRGSISTSRLLSSAAGRGPAAAAAAALGPAGAAAAAARRSYSLIPMVIEHSSRGERAYDIFSRLLKERIVCINGPISDDTAHVVVAQLLFLESENPSKPIHMYLNSPGGAVTAGLAIYDTMQYIKSPINTICLGQAASMGSLLLSAGAKGERRSLPNATIMIHQPSGGYSGQAKDMTIHTKQIIRVWDSLNALYAKHTGQSVDVIQKNMDRDYFMTPGEAKEFGIIDEVIDQRPIALVTDAVGHEGKDTDKSSS | 179 |
A9TX19 | 1.11.1.7 | ACT_SITE 85; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MARIHRDVSVLGSMALVALCLYCGVAGAVLNYTPGLRYDFYKNSCPRADDIVFEQMTEIFKTKPTAQDGDFGKNVAPDLLRLHFHDCFVRGCEGSVLMDKPGSEKTAPPNGRLEGFDAVDKIKAALEGECPGTVSCADLLAFAARDGVRLTGGFFYRVPAGRRDGYDSIAAEATKNLPDPRMNVDQLTLNFKNQGLTRDEMVILSGAHTIGDVACHHIDNRLYTYPGNNGVVPSLPRAFVKKLKGICPRPNLFDITVDMDQVTPIRFDSQYYKNLASKTSVLSSDQVLYDDVRTRPLVRVLESKLAFLSKFGPAMVRMGN... | 14 |
A0A9J7LH58 | 2.7.10.1 | ACT_SITE 713; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000615-1" | MMFVTLADVTVTVTAPQGVLVGQQAIINCTINPDQGAAVTWTKDGHVVPDASTTVLRHGAGPINNGRYNEYRDRDIDIVGRASLRIQNTSLSDNGEFYCTVTVSGPLVVGPDSAVLTVFGRTGPPTISLSGTPSTEYPLTLTCTTAGGYPAATISWYRGNENRTGEAEDQTDVEETDGSVTSSRQYTFTPTKNDTGVSYKCVVSQSVLQMDLEAETTFNVTYPAQITPTPPVTTSVIVGQTANFSCPAEGNPNNFTYIWKEGNRTINSAHEDQFSQSDGVLTISNVQRNQHDVTCEVTNNIGRADTASTTLDVQHAPDVS... | 97 |
A0A2C9W9W6 | 3.1.1.11 | ACT_SITE 377; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MASSIVLSLLLLLSPIFFVSTFALGDTSPASVDTHLSSLREFCNGTPYPDACFNSLKLSISINIDTDLISYLLHTLQTAISEVEKLTNLFSSAGGSNDIIEKQRGTIQDCQQLQQITLSKLQRISVSGIQLGDPRKLADARSYLSAALTNKKTCLEGLDSASGPLKSVLINSLTSTYTHVSNSLSMLPKQGPKKGGKNRRLLGFPRWISKKDRLFLQSGTSKYDTSEMIVVAADGSGNFSTITDAIKFAPSRSEYRIFIYLKEGVYKENVEIPANKPNIVLLGDGSDVTFITGSRSVGDGWTTFRSATLGVSGDGFLARD... | 125 |
A0A3Q1NDQ7 | 3.2.1.23 | ACT_SITE 189; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR006336-1"; ACT_SITE 269; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR006336-1" | GASDFWSVALSIVTFLLREMQGSSRNATQRTFQIDYRRNRFLKDGQPFRYISGSIHYFRVPRFYWKDRLLKMKMAGLNAIQTYVAWNFHELQPGRYNFSGDHDVEHFIQLAHELGLLVILRPGPYICAEWDMVSVANLASKKVCDGVKPGCFPDYLAAVDKWLGVLLPKMRPLLYKNGGPIITVQVENEYGSYLSCDYDYLRFLQKRFHDHLGEDVLLFTTDGVNERLLQCGALQGLYATVDFSPGTNLTAAFMLQRKFEPTGPLVNSEFYTGWLDHWGQRHSTVSSKAVAFTLHDMLALGANVNMYMFIGGTNFAYWNG... | 163 |
O94487 | 2.7.11.1 | ACT_SITE 285; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MDLLGLKELDNNKLVSKAKENGVEFSDLFLLSSGYLRDRENASASVSSKNERMVLNEERQNCWTKRNDPKGLTYYQLLKPSEVEILSRPETRRKRMACQVFFLNYYISTIEYHKLRKERLEEFTACTSSLKQSKQKRLWKEHCGRERAFLRKKRTKIQCSHFDLLVKLGQGGYGSVWLAKKRNTHELLAMKMMKKSTLQQLNEVKHILNERDILTNTNSEWLVKLYYAFQDKEKVYLAMEYVPGGDFRTFLTTKGLLHENQTRFYLAEMVAAISAVHKLGYMHRDLKPENFLIDQKGHIKLSDFGLSTAIVTSNQVNRLQ... | 99 |
Q86UX6 | 2.7.11.1 | ACT_SITE 216; /note="Proton acceptor"; /evidence="ECO:0000250|UniProtKB:Q60592, ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MRSGAERRGSSAAASPGSPPPGRARPAGSDAPSALPPPAAGQPRARDSGDVRSQPRPLFQWSKWKKRMGSSMSAATARRPVFDDKEDVNFDHFQILRAIGKGSFGKVCIVQKRDTEKMYAMKYMNKQQCIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICEMALALDYLRGQHIIHRDVKPDNILLDERGHAHLTDFNIATIIKDGERATALAGTKPYMAPEIFHSFVNGGTGYSFEVDWWSVGVMAYELLRGWRPYDIHSSNAVESLVQLFSTVSVQYVPT... | 99 |
C4M0I9 | 3.4.25.1 | ACT_SITE 15; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR600243-1" | MEFTHNAYQPISLGTTIIGVVYNGGVLLGADGRTSMGSIVVNRCKNKIRMVSDSIGMCTAGTAAHSETIGDYVKHALRMYTAQTGEEPTVLAAATSIKNIIYGNKSFLSSSVVCGGYDPVNGATLYRILQSGAMKQDDICVGGSGSTYIWGYCDAHFKKNMTFEEAKQFIVTAVSLAIYRDGSSGGIIHTVNITAEGVQSEFITGDKVPVPQN | 180 |
C0LGG9 | 2.7.11.1 | ACT_SITE 793; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MGFFFSTRKGLLLIIFICLDIFGSNAQLLPEDEVQTLRTIFRKLQNQTVNIERTSCLDRKWNFVAESTSKLPTSNITCDCTFNASSVCRVTNIQLRGFNLRGIIPPEFGNLTRLTEIDLVLNFLSGTIPTTLSQIPLEILAVTGNRLSGPFPPQLGQITTLTDVIMESNLFTGQLPPNLGNLRSLKRLLISSNNITGRIPESLSNLKNLTNFRIDGNSLSGKIPDFIGNWTRLVRLDLQGTSMEGPIPASISNLKNLTELRITDLRGPTSPFPDLQNMTNMERLVLRNCLIREPIPEYIGTSMTMLKLLDLSSNMLNGTI... | 99 |
A0A7M7N573 | 2.7.11.1 | ACT_SITE 211; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR630616-1" | MTSEYGKENSTQAHMSSKAHMTPVSVPRANAGPKRILKPNTTSSNVASSLNRGTTAQARTQPVKSAENGHGHDDKQMEPKKSWTLKDFDIGRPLGKGKFGSVYLAREKQTKYIVALKVLFKSQLQKAQVEHQLRREIEIQSHLRHPNILRLFGYFYDESRVYLILEYAPRGELYKQLQRAGRFDEQRTASYISQLADALKYCHSKKVIHRDIKPENLLLGLLGDLKIADFGWSVHAPSSRRNTLCGTMDYLPPEMIEGRMHDDKVDLWSLGVLCYEFLVGKPPFEAEGSTETYRRITKVHYQFPSYVSAGARDVIKRLLQ... | 99 |
A0A9J7NAB6 | 3.4.19.9 | ACT_SITE 132; /note="Nucleophile"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00607"; ACT_SITE 244; /evidence="ECO:0000256|PROSITE-ProRule:PRU00607"; ACT_SITE 375; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR615527-1, ECO:0000256|PROSITE-ProRule:PRU00607"; ACT_SITE 487; /evidence="ECO:0000256|PROSITE-ProRule:... | MMANLAVLNLVIVAVGIAQGLSVRDFPEVNDRPIIGVIAQASGGAIAKFGKTYIPASYIKYLESAGARVVPIRVNLTTAEYTKLFNSLNGVLYPGGSVNLFTSGYAKSAKIFYDLAIKAFDEGDYFPVWGTCMGFQQLTALTSDRNVLTTCKGTENKSYKLNFSKDYMSSRMFGKVPVDILTDLATLPLTPNFHKYCLTPQIFTDDAKLKSFYKILSTNTDDDGMEFVSSMEAIKYPVYGVQWHPEKNNFEFGSILKITHSDAATRVSQAMANFLVSEGVIAQASGEARAKFGKTYIPATYIKYLESAGARVVPIRVNLT... | 176 |
B8BTK3 | 1.1.1.100 | ACT_SITE 222; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR611284-1" | MDLSAMLHTLSAIDTHTFSLSSYNNTNTMKFSALFSFGLLATASAFAPATPLNLSTSTRQRASQISMVADDAKVILVTGASRGLGAAIAIDLGKQGQKVVVNYAGSKDKAEEVVEAVKAAGGDAIAVQADCSDPDSIKAMFKTIVEEYGTCDVLINNAGITQDGLVMRMKPSQWQAVIDTNLSGVFYTTQEFFKIASKKKTGRIINMSSVVGQIGNPGQANYAAAKAGVIGLSMSNAKEFSKRGITVNVVCPGFIESDMTGKLTDEYLEEVSNGIPLGRLGKPSEVAGMTRFLALDPAADYITGHCFNVDGGIAIGA | 2 |
A0E455 | 1.8.1.4 | ACT_SITE 467; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000350-2" | MFKTRYLITNQFTHFQRSSFSSQPFDLVVIGGGPGGYVAAIKAAQLGLKTACVEKRGSLGGTCLNVGCIPSKALLNISHKYEDAHKNFKGLGIKVDNLGVDWAQVQKKKGDIVGSLTKGIEGLFAKNKVSYYKGWGKFTSKNEIAIDLNDGKKETITTKNTLIATGSEPTPFPGLDFDEKIIISSTGALALQQIPKKLVVIGGGVIGVEMASVYQRLGTEVTVVEYLDNICGAIDLEVSKAFQKILTKQGMKFLIGHKVLGGKNLGNAAEVVIEPVKGGDKITLTADHVLVSTGRRPYTQGLNAESIGVKLDNRGRIQIG... | 36 |
Q7NH89 | 3.1.26.3 | ACT_SITE 60; /evidence="ECO:0000255|HAMAP-Rule:MF_00104"; ACT_SITE 131; /evidence="ECO:0000255|HAMAP-Rule:MF_00104" | MAESALTPLRLAQLRRFAARFALSEPEALSWELLHRALIHPSWSAQEGGEDNDRLEFLGDEILRLLAAEFLYRADPELTVGEMTAVRSVLVSDVALAELAEGYDLGEFLVVGRSASGDERGRITRLADGFEAVIGALYLSTGDLGLIRPWLLPHLAHLAESVMADPTRGNHKSALQELTQKLAAGELPEYRLVDPGPPFRYEVWALGRLWGSGEGPSKKLAQQRAARGAYAALRSAFDTALQ | 138 |
A0A804K800 | 3.5.4.5 | ACT_SITE 136; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR006334-1" | MPCPPPSPLFTSQLAGKTKDTNQFLSCICTFLSVCVRVISIRFLIGEREEMEKPARSTVGKFVIEAEEAQAMAKESGVAAVRELLPLLVPAAQRLARPPISNYRVGAVGLGASGRIFLGVNLEFPGLPLHHSVHAEQFLMANANAHGEPSIGCVAVSSVPCGHCRQFLQEIRGAAEIQILVTSDEDPAFRPLASLLPHPFGPPDLLHKDAPLLLEPHDNDFGALDATGVAVGGGGLCNGIGGGGLERRLREAAEGAARSSHAPYSGCAAGFAVADGGGRVYSGSYVESAAYNPSLGPAQAAMVACLAAGGGGEGEGGGWG... | 187 |
A0A0R0G2T3 | 3.1.1.11 | ACT_SITE 383; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | FVSSAIDRIIHGPFSRCIQNVMINMHISQQGTIEYREKKTYSYHKLFFLLFAIFFSHTCINSSNTSTTVQVDLSSIRSFCITTPYPEVCFNSLNVSIPIDTNPNSNSYFLQSLQVAIYETTKLLNLFNNVRPSNIKEKQKGAIQDCRELHQSTLASLKRSLSGISSFKITLIDARIYLSAALSNKNTCLEGLDSASGTMKPVLVKSVVNTYKHSLVGDSKWLSSTDLGFFQDSDGDGYDPNEVIVVAVDGTGKFSTITVRDRTVIRVKEGIYKENVVIQSYKINIVMLGDGSDVTVITGNRSVGDGCTTFNSATLAVSGE... | 125 |
H3GA77 | 3.1.1.11 | ACT_SITE 200; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MRVFASLLVLAGLATSATTAIDGACTGPNARTEPPVGAVVVDATGTYAGSFKTVSEGVAHLPNTTVEHTLFVFPGVYKEQVVVPKLKGSLVVQGYTCDAMSYADNEVTITHAMAQKDVPASITSGRDAYTSTLWLKPNNVKVYNLNVANTAGNVGQAIAMKVDGTNYGFYACNLTGYQDTLYANKGPELFARSYISGAVDFIFGLYAKAWFESCDFESVGKGCVTADGRNNDTNPSYYVFNNARVFGSGGAGTAFLGRPWKPYARVVWQNSELSDVINPQGWQEWNNDPNTQNVYFKEFNNSGPGATTDKRAAFSGQLAA... | 125 |
Q4QD53 | 1.1.1.205 | ACT_SITE 327; /note="Thioimidate intermediate"; /evidence="ECO:0000256|HAMAP-Rule:MF_03156, ECO:0000256|PIRSR:PIRSR000130-1"; ACT_SITE 425; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03156, ECO:0000256|PIRSR:PIRSR000130-1" | MATNNANYRIKTIKDGCTAEELFRGDGLTYNDFIILPGFIDFGAADVNISGQFTKRIRLHIPIVSSPMDTITENEMAKTMALMGGVGVLHNNCTVERQVEMVKSVKAYRNGFISKPKSVPPNTPISNIIRIKEEKGISGILVTENGDPHGKLLGIVCTKDIDYVKNKDTPVSAVMTRREKMTVERAPIQLEEAMDVLNRSRYGYLPIVNENGEVVNLCSRRDAVRARDYPHSTLDKSGRLICAAATSTRPEDKRRVAALADVGVDVLVLDSSQGNTIYQIAFIKWVKSTYPHLEVVAGNVVTQDQAKNLIDAGADGIRIG... | 3 |
B5YJI8 | 4.2.1.20 | ACT_SITE 52; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_00131"; ACT_SITE 63; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_00131" | MKQGFAVRKKIEEIKNQGKKAFIPYIMAGDPNLEETAKRLKILEQAGADLIELGVPFSDPLADGPTIQKAAERALNSGTTLRKILNFLEDFKKSINTPIILMTYLNPVFCYGIERFFHDAKGVNVGGVIFPDLTVEESKYYRTFAKKYGIDTIFLVAPTSTPERVKKIVKASTGFVYYVSITGITGTTLSLDKSFNDHINFVKSFGKPVCVGFGVSKPEEAKYISRIADGVIVGSAIVKIFHEKPEKASEFIKSLREAI | 202 |
P9WKE3 | 2.7.6.1 | ACT_SITE 202; /evidence="ECO:0000255|HAMAP-Rule:MF_00583" | MSHDWTDNRKNLMLFAGRAHPELAEQVAKELDVHVTSQDAREFANGEIFVRFHESVRGCDAFVLQSCPAPVNRWLMEQLIMIDALKRGSAKRITAVMPFYPYARQDKKHRGREPISARLIADLLKTAGADRIVTVDLHTDQIQGFFDGPVDHMRGQNLLTGYIRDNYPDGNMVVVSPDSGRVRIAEKWADALGGVPLAFIHKTRDPRVPNQVVSNRVVGDVAGRTCVLIDDMIDTGGTIAGAVALLHNDGAGDVIIAATHGVLSDPAAQRLASCGAREVIVTNTLPIGEDKRFPQLTVLSIAPLLASTIRAVFENGSVTG... | 114 |
A9WE57 | 2.6.1.16 | ACT_SITE 2; /note="Nucleophile; for GATase activity"; /evidence="ECO:0000256|HAMAP-Rule:MF_00164"; ACT_SITE 615; /note="For Fru-6P isomerization activity"; /evidence="ECO:0000256|HAMAP-Rule:MF_00164" | MCGIVGYIGGREATEVVLNGLQRLEYRGYDSAGIAIYHPDAGLQLRRSVGKLINLQQRVQADPPRGRVGIGHTRWATHGGVTEQNAHPHRDASGTIVVIQNGIVENYLSLKGRLIELGYQFESQTDTEVIAKLIGHYYQEQRDLVAATRQALQELRGGNAVVAFCIHEPDTLVAARLGNAGGIAIGLGDNEQFIASDIPAILDYTRNLIFLEDHDIAVVRRDEVTITRLDGTPVTRAVHSIAWDPVAAAKGDYRHFMHKEIDEQPRALMDVLRGRIDQERGLITLEDLRLDDQDLRRVRRIYAIACGTAWHAALVAKFMI... | 81 |
B7PF83 | 3.1.1.3 | ACT_SITE 151; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR000865-1"; ACT_SITE 174; /note="Charge relay system"; /evidence="ECO:0000256|PIRSR:PIRSR000865-1"; ACT_SITE 262; /note="Charge relay system"; /evidence="ECO:0000256|PIRSR:PIRSR000865-1" | MPDLGCFRNGGHWFHLLYRPLSLLPDDRYLVNTSFLLFTRNNPEVQEYLHTSSHRDMEETSFRPYKPTKLIVHGFMDNIIVGNWIFEMKDRFLDTMDCNVIVVDWRGGNVLPYTQATANCRVVGAEIAHLVKTLEQTFGAKQESFHCIGHSLGAQICGYAGARLQGLGRISGLDPAGPFFYRMPPEVRLDPSDAKFVDVIHSDASMPYMLIEGFGVNEMVGHVDFYPNNGNNQPGCQKYNFRKFVDKGGLIDGVRRFSSCDHIRSLDFYMESITNDMGCLPVAVSCASWEDFEAGRCSKCGSRGSDCAVMGFYSDRMRTG... | 128 |
D8SHJ0 | 3.2.1.52 | ACT_SITE 155; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR625705-1" | MGPYEDSSQICTYNAVERAVLLQGCPWNIFDEPRFSYRGLLIGCLALACCRRGVLPFGDSIVSKGSYSISQRYNLDDAKAIVKYARLRGIHVMPEIDVPGHARSWGVGYPELWPSENCKTPLDISKNFTFEVIDGIFSDLSKVFPFELLHIGGDEVNTRCWEITEPVNDWLRKHNLTPSQGYEFFVLQVQKLALKHGYVPVNWQEPFEKFGPSLSRKTIVHNWWGTQIPPNTVSSGLKSIVSEQFSWSH | 170 |
A0A8M3AS91 | 2.3.1.48 | ACT_SITE 408; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR602717-51" | MADHSVEITEGCRLPVLRRNQENEDEWPLAEILSVKDISGRKLYYVHYVDFNKRLDEWVTPDRLDIKKLQFPKKEAKTPMKNGLSGSRPSSPERDVKRKAESVSLATQVTAATPVPSLPASTEASQAALYTAIRDASFNIKSREEHEPLTSLTTNGTTSIQRHLIPPQPGRKRKNCGGTDEMVKVFQNNSPRCSTVYLLPGEDSQDSSDGIPSAPRMTGSLVSDRSHDDIVTRMKNIGCIELGRHRLKPWYFSPYPQELTSLPIIYLCEFCLKYLKSLKCLQRHLTKCNLRHPPGNEIYRKGTISFFEIDGRKNKAYSQN... | 61 |
Q8I2S7 | 1.1.1.100 | ACT_SITE 209; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR611284-1" | MSVLHRFYLFFLFTKFFHCYKISYVLKNAKLAPNHAIKNINSLNLLSENKKENYYYCGENKVALVTGAGRGIGREIAKMLAKSVSHVICISRTQKSCDSVVDEIKSFGYESSGYAGDVSKKEEISEVINKILTEHKNVDILVNNAGITRDNLFLRMKNDEWEDVLRTNLNSLFYITQPISKRMINNRYGRIINISSIVGLTGNVGQANYSSSKAGVIGFTKSLAKELASRNITVNAIAPGFISSDMTDKISEQIKKNIISNIPAGRMGTPEEVANLACFLSSDKSGYINGRVFVIDGGLSP | 2 |
A0A1U8FWC4 | 1.11.1.7 | ACT_SITE 75; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MNSKNGAFISVFSFLVFLPVMVQAVTVLPVSIPSLRYGYYDEKCDSVEDIVWSKMKKIVQLQHNAPAQLLRLMFHDCFIGGCDASVLLVGMNGTVERDAIPNKTLKGFDFIDMIKDEIEEACPGVVSCSDILVLATRDGIVLAGGPYYPVLTGRRDNNESFFDMANAEIPRPNGNISETLRLFSLRGFDERETVTLLGGHNIGRIGCEFIRPRLSNFTGTGLPDPTISPDFLEELKRKCPQDNNIINNMLNEHTTRGLSEFAISSAAFFDNHYYKTLMRGKGLLFSDQQLMANEKTAAAVTDYSYDDGTIFRTEFAHAMG... | 14 |
K7MB82 | 2.3.2.26 | ACT_SITE 999; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MFFSGDSSTRKRVDLGGRSSKERDRNNLLEQTRLERNRRMWLRQQNSAALRIQKCFRGRKVVRTEQSKLREKFLSIYGKNCQNLDRNAYAPGSDFLRQFLYFFNAENIDDFLILVQICRMLQRFVQDSGDVVRLFAGVDYSSTCALVNYRVKQFVYTCICAVHQNRNKLKDQLLLTPKDFNASAIPLLEILVLLIDPKLPWSCKTVVSLSQNNAFGLLREIILTGKDNAENCIYSEKGSSLECVLTVVMCHIGQKPCICSHTDPLYSFSSQILTIPFLWHVFPNLKQVFAKQGLSQHYVHQMATWVPNLISSLPKDISDE... | 65 |
B9IAC3 | 3.1.1.11 | ACT_SITE 425; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MYTMPKFFHANPRDKKTSFMAALSILLIIKILCLATFAEATTSKPLPSQFAKLSRSTTTPGAPSSTDTSPCKGTPYKAACQSLLLTLNTNNNADLPKTPKELFDYSVHFTSSQAHSAIDQLATTFLGQTYQEIDMTHLPGSGMRDCMELLDDTLDQLSNVINRKNDPTHTHNDVQTWLSAALTNQETCKESLLENVKKTHLEKFNVIDSMAKNLSQFISNSLALYVSSYGLPSTSPRGRKLLTDQSNIINDFPSWVSLSERKLLEASVGEIEAHAVVARDGSGTHTSIAEAIRQVAASLDGGGRNVIYIKAGTYKENLNI... | 125 |
Q8A1X6 | 5.1.3.3 | ACT_SITE 203; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1"; ACT_SITE 340; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1" | MKNLALWAVSALFVAACTPKAEQPTDSGLLRTNFQTEVGGKKTDLYTLRNKNNMEVCVTNFGGRIVSVMVPDKDGKMQDVVLGFDSIQDYISKPSDFGASIGRYANRINQGRFTLDSIEYQLPQNNYGHCLHGGPNGFQYRVFDAVQPNPQEVELTYVAADGEEGFPGNITCKVLMKLTDDNAIDIRYEAETDKPTIVNMTNHSYFNLDGDAASNADHLLMVDADYYTPVDSTFMTTGEIVPVEGTPMDFRTPTPVGARINDYDFVQLKNGNGYDHNWVLNAKGDISRKCASLESPKTGIVLDVYTNEPGVQVYAGNFLD... | 211 |
A0A7M7PQD5 | 2.3.1.286 | ACT_SITE 184; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR037938-1, ECO:0000256|PROSITE-ProRule:PRU00236" | MSAKNEGAAAGADDKEGDQSESVDSQVESLRNFLGRFHLSAGSSGQEEKPKPEQLLKELTLEGIADFIKEGKCKKVIVMSGAGISTSAGIPDFRTPGTGLYDNLQKYNLPNPQAIFEIGFFKENPEPFFTLSKELFPGAFYPTPSHFFIHLLHEKGILLRHYTQNIDGLDRMAGVPDELIMEAHGSFHTGHCLNCNEMYTEESMREKIMADLIPRCAKCNETGVVKPDVVFFGESLPPRFPTLVSEDFPQCDLLIVMGTSLVVQPFASLIDKVPEMTPRLLINMEKSGKADPMMMMFGFPSGMDFDSDDKYRDVAYIGPC... | 58 |
H2Y3K9 | 1.1.1.37 | ACT_SITE 187; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000102-1" | MADGLKVLVTGAAGQIAYSLLYSIANGDVFGKDKSITLVMLDIAPMAEALKGVVMELQDCALPSLKNVISTTDVKEAFTDIDFAILVGAMPRRQGMERKDLLKANAKIFVEQGQALEKYAKKTVKVLVVGNPANTNCLIALTCAPSIPKTNFTCLTRLDQNRAQSQIASRLGVSNDSVSNMIIWGNHSSTQFPDAAHASAVVGGSTANAVEAVKDDAWLNGDFISTVQKRGGAVIAARKLSSAMSAAKAICDHVRDWYFGTKGDKWTSMGIYSNGSHYGLPENIVYSVPVRIAPGGEYTVVEGLKISDFARSKMDATAQE... | 5 |
A0CPT1 | 3.4.19.9 | ACT_SITE 127; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR615527-1, ECO:0000256|PROSITE-ProRule:PRU00607"; ACT_SITE 239; /evidence="ECO:0000256|PROSITE-ProRule:PRU00607"; ACT_SITE 239; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR615527-1" | MKIILFFVLLIGIHHSLNLNPVIGILTIPSDEDYQDYPSSQYSYIAASYVKYVESSGARVMPIPYEADEATLDKYFSQINGLLLTGGTLELETEQGPSKYLQTVTHLLNKVLKANQQGDTFPLFAICLGHQTLHFILSNKDYDVLTPASGMETVNKKLLFKDKYSTIFIDLKESIFKSIETKEQVYFNTDWAVLPSYYDTHSQLNDFFKIVALVKDSQEVVSIAAAEAREYPIFSLAFHPEKAAFEFKSQSKHNQESIQFGRNLINQFTQIARENSHILQDSNSTIFKNNPIQLSSASFVQIYFFKLGELGI | 176 |
Q2FX12 | 3.1.3.48 | ACT_SITE 8; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:P11064"; ACT_SITE 14; /evidence="ECO:0000250|UniProtKB:P11064"; ACT_SITE 120; /note="Proton donor"; /evidence="ECO:0000250|UniProtKB:P11064" | MVDVAFVCLGNICRSPMAEAIMRQRLKDRNIHDIKVHSRGTGSWNLGEPPHEGTQKILNKHNIPFDGMISELFEATDDFDYIVAMDQSNVDNIKSINPNLKGQLFKLLEFSNMEESDVPDPYYTNNFEGVYDMVLSSCDNLIDYIVKDANLKEG | 149 |
A0A1U8A3K5 | 3.1.1.11 | ACT_SITE 414; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MFGINDLFARASDSDKCICKNKRPLLVLLASFLLVVTVIGVIARVTTHKNSSSDNGSLAHAILKSSCRSTLYPDLCYSAIATVPGAMDNLSTQKDIIEMSLNITTTAVEHNYFTIEKIIGSKNLTKREKTALHDCLEMVDETLDELHKTADDLKDYPSSKKSIFQHADDLKILVSAAMTNQESCIDGFSHDNADKDVRKKLLAGQEHVYRMCSNALAMIKNMTDTDMAQEQYKAKRRVEESSEEFPAWLSWGDRKLLQASMLVPDVTVAADGSGHYTTVSEAVAAAPEKSHKRYIIRIKAGVYRENVNVPKKKTNIMMVG... | 125 |
P50620 | 1.17.4.1 | ACT_SITE 380; /note="Proton acceptor"; /evidence="ECO:0000250"; ACT_SITE 382; /note="Cysteine radical intermediate"; /evidence="ECO:0000250"; ACT_SITE 384; /note="Proton acceptor"; /evidence="ECO:0000250" | MSQNQVPKWIQLNNEIMIQKDGKFQFDKDKEAVHSYFVDYINQNTVFFHNLKEKLDYLVENQYYEEEFLSLYSFEDIKEVFKTAYAKKFRFPSFMSAFKFYNDYALKTNDKKKILERYEDRISIVALFFANGDTEKAKEYVNLMINQEYQPSTPTFLNAGRKRRGELVSCFLLEVNDSLNDISRAIDISMQLSKLGGGVSLNLSKLRAKGEAIKDVENATKGVVGVMKLLDNAFRYADQMGQRQGSGAAYLNIFHRDINDFLDTKKISADEDVRVKTLSIGVVIPDKFVELAREDKAAYVFYPHTIYKEYGQHMDEMDMN... | 21 |
P22498 | 3.2.1.23 | ACT_SITE 206; /note="Proton donor"; /evidence="ECO:0000255"; ACT_SITE 387; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10055" | MYSFPNSFRFGWSQAGFQSEMGTPGSEDPNTDWYKWVHDPENMAAGLVSGDLPENGPGYWGNYKTFHDNAQKMGLKIARLNVEWSRIFPNPLPRPQNFDESKQDVTEVEINENELKRLDEYANKDALNHYREIFKDLKSRGLYFILNMYHWPLPLWLHDPIRVRRGDFTGPSGWLSTRTVYEFARFSAYIAWKFDDLVDEYSTMNEPNVVGGLGYVGVKSGFPPGYLSFELSRRAMYNIIQAHARAYDGIKSVSKKPVGIIYANSSFQPLTDKDMEAVEMAENDNRWWFFDAIIRGEITRGNEKIVRDDLKGRLDWIGVN... | 163 |
W5NHA0 | 3.1.3.48 | ACT_SITE 467; /note="Phosphocysteine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR001997-1" | LQTLQVDIRRLNVTLLRAFRDGVAAALDISPQQVHINRLNEKKNCIELYVSSEKLGEAEPVPSEEVIRSLNVNILHKSLSQFGITEVTPEKNVLQGQHERDNVWTNEGFYAVVIFLTIFVIIITCLMVLYRLKEKIEFPDRQYKEQSREIHLTPIPVHTKESQLKTANSMVQPELAPKPASIGADPQSQSTPEIKPCLSASPSPFRMKPVGLQERRGSNVSLTLDMSSLGNVEPLSSGQTPRERVAMEYLQTASRTLTRKQLREVVANTQILHAEFVEIPMNFVDPKDLDIPSHGTKNRYKTILPNPHSRVCLKTKNIYD... | 149 |
P9WJM5 | 1.8.4.11 | ACT_SITE 13; /evidence="ECO:0000255|HAMAP-Rule:MF_01401" | MTSNQKAILAGGCFWGLQDLIRNQPGVVSTRVGYSGGNIPNATYRNHGTHAEAVEIIFDPTVTDYRTLLEFFFQIHDPTTKDRQGNDRGTSYRSAIFYFDEQQKRIALDTIADVEASGLWPGKVVTEVSPAGDFWEAEPEHQDYLQRYPNGYTCHFVRPGWRLPRRTAESALRASLSPELGT | 39 |
E7F646 | 3.1.4.11 | ACT_SITE 305; /evidence="ECO:0000256|PIRSR:PIRSR628391-1"; ACT_SITE 350; /evidence="ECO:0000256|PIRSR:PIRSR628391-1" | MESPQACRQQGRQNLEAMKAGMFFRKVKSRMWRRQRHYKLQDDCKTIAYKSSWAINSYSTFSISDVEAVREGHQSEALLGVADEFPPDRCFTLVFRGRKGNLDLVAESAEEAQAWIQGVRGLMENMENMDESTKLDQWISDWFSKADRNKDGRINFKEAKKLLKMMNIDMNEEHACCLFKMADKSRSGTLEDQEFVEFYKMLTERREVLDLFQDYSSDGQILSQCDLEEFLREEQLEGESSYEHALQLIDRYEPSETARMNHSMSVDGFLMYLTSPEGSIFNPERQGIFQDMSQSLAHYYISSSHNTYLMEDQLKGPSSV... | 153 |
A0A804K9T6 | 3.1.1.11 | ACT_SITE 384; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MALTSDVLLLLLLFLPGIYAQWSQSSSLEEAKAFEESLLHQACLNTTDHEACTSRISIECHRQGRTGPISILHGAVRGTIDEALRAVGTLSGLAAVSSDLREEMAIHDCVELLGYSIDELGWSLEEISRLVLENRNIHHEANLRAWLSAALSNQDTCLEGFDGTDGRIRHYIHSRVAEVTQLVSNLLVMYRKMRSIIPHAPPRNGTKSDGNRDSPPWVVVDQELLHADPKALRADAVVASDGSGRYRSINEAVNRAPIHSSRRYVIYVKKGVYEENVELKKKKTNIMIVGDGMGITVISGSRNFMQGWTTFRTATFAVSG... | 125 |
Q9LXI4 | 3.1.3.2 | ACT_SITE 306; /note="Proton donor"; /evidence="ECO:0000250" | MKKMKIFGFLISFSLFFLSPFVCQANYDSNFTRPPPRPLFIVSHGRPKFYPQQVHISLAGKDHMRVTYTTDDLNVASMVEYGKHPKKYDKKTAGESTSYTYFFYNSGKIHHVKIGPLKPNTKYYYRCGGHGDEFSFKTPPSKFPIEFAVAGDLGQTDWTVRTLDQIRKRDFDVFLLPGDLSYADTHQPLWDSFGRLLETLASTRPWMVTEGNHEIESFPTNDHISFKSYNARWLMPHAESLSHSNLYYSFDVAGVHTVMLGSYTPYESHSDQYHWLQADLRKVDRKKTPWLVVVMHTPWYSTNKAHYGEGEKMRSALESL... | 145 |
P35761 | 2.7.12.1 | ACT_SITE 646; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MEAEELIGSSVTIDSIMSKMRDIKNKINEDCTDELSLSKICADHTETVNQIMRVGNTPENWLNFLLKLEKNSSPLNDDLLNKLIGRYSQAIEVLPPDKYGQNESFARIQVRLAELKAIQEPDDARDYFQMARENCKKFAFVHVSFAQFELSQGNLKKSEQLLHKAVETGAVPLQMLETAMRNLHLQKKQLLPEEDKKSVSASTVLSAQEPFSSSLGNVQNRSISCESRGQAGAARVLYGENLPPQDAEVRHQNPFKQTHAAKRSCPFGRVPVNLLNSPDFYVKTDSSAVTQLTTRLALSSVPLPYVTCLLHLQLLALAGL... | 107 |
T1G579 | 3.1.3.16 | ACT_SITE 109; /note="Phosphocysteine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR620405-1" | MKVILDGYPQHSPPIHPTKLTDQLYIGNQDNADDVILLQGLEITHVLNCAGTRNFDLTRSPYPLSSGITNFLMIPAQDYDEFDIMQFFEDAIGFLDSATLSGGRAFVHCSIGVNRSGAIVAAYMMISQKKRLLDVIVELKAKRLLILCNMGFRKQL | 144 |
P9WIS1 | 1.2.4.4 | ACT_SITE 151; /note="Proton acceptor"; /evidence="ECO:0000250" | MTQIADRPARPDETLAVAVSDITQSLTMVQAINRALYDAMAADERVLVFGEDVAVEGGVFRVTEGLADTFGADRCFDTPLAESAIIGIAVGLALRGFVPVPEIQFDGFSYPAFDQVVSHLAKYRTRTRGEVDMPVTVRIPSFGGIGAAEHHSDSTESYWVHTAGLKVVVPSTPGDAYWLLRHAIACPDPVMYLEPKRRYHGRGMVDTSRPEPPIGHAMVRRSGTDVTVVTYGNLVSTALSSADTAEQQHDWSLEVIDLRSLAPLDFDTIAASIQRTGRCVVMHEGPRSLGYGAGLAARIQEEMFYQLEAPVLRACGFDTP... | 25 |
A0NH65 | 1.11.1.24 | ACT_SITE 85; /note="Cysteine sulfenic acid (-SOH) intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR637944-1" | MHSFVRSSCAVVKNFFVLNQCGRPVLLNAAATFHTSKMVQIKEGDKIPSIDLFEDSPANKVNMADLCAGKKVILFAVPGAFTPGCSKTHLPGYVEKAGDLKSSGATEIVCVSVNDPFVMSAWGKQHNATGKVRMLADPAAAFTKALELGADLPPLGGLRSKRYSMVLEDGVVKSLNVEPDGTGLSCSLADKIKL | 12 |
F6T688 | 3.1.3.48 | ACT_SITE 565; /note="Phosphocysteine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR001997-1" | MIWSTARAALAVQAQSYHQGRLGLKPEAEHCFHQSLKARRAESLGIWALRGRSAIPSCVAWGGSLHFSESPLSPLEDTGVQGNHAADDSEGGALDMCCSERLPGLPEPGVMEALDQAEGLTDSQREMPPPPPPSPPSEPAQEPPPPGAGSHSLTVRSSLCLLAASQVLLACGMLWLSGYCPLWSQNATDLLSSLLALLEQLGPTAWLGIGTWDIPSLLLVSLTVVLVTTLVWHLLRAPPEPSAPLPPEDRRQSVSRQPSFTYSEWMEEKVEDDFLDLDPVPETPVFDCTMDIKPEADPASLTVKSMGLQERRGSNVSLTL... | 149 |
P14747 | 3.1.3.16 | ACT_SITE 205; /note="Proton donor"; /evidence="ECO:0000250" | MSSDAIRNTEQINAAIKIIENKTERPQSSTTPIDSKASTVAAANSTATETSRDLTQYTLDDGRVVSTNRRIMNKVPAITSHVPTDEELFQPNGIPRHEFLRDHFKREGKLSAAQAARIVTLATELFSKEPNLISVPAPITVCGDIHGQYFDLLKLFEVGGDPATTSYLFLGDYVDRGSFSFECLIYLYSLKLNFNDHFWLLRGNHECKHLTSYFTFKNEMLHKYNLDIYEKCCESFNNLPLAALMNGQYLCVHGGISPELNSLQDINNLNRFREIPSHGLMCDLLWADPIEEYDEVLDKDLTEEDIVNSKTMVPHHGKMA... | 144 |
A7SFL2 | 2.5.1.18 | ACT_SITE 16; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR006386-1" | MAVSRRTVELFYDVVSPYSWIAFEVLCRYRPKWNLDLKFRPCFLGGIMSSSGNRPPGLVPNKAKYMVKDIERQREYYGIPIAQPSNPVEVMFEKGSLSAMRLLTAIDIAHPDKIEQLSRELWMRIWSRDEDIVLPESLKQACLATGFSDTQSTAIISRLSDQDIKDKLKETTQEALDAGAFGAPTIIAHANGAKHMFFGSDRFFLIAHLYGKEMFLRDLSTDYHRYFFYRCTAQFRQI | 77 |
A0A0A0LYF5 | 3.1.1.11 | ACT_SITE 411; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MGYKDDDSQNKKRYAIIGVSSMLLVAMVVAVTVGVNLNQDETSDPATGNKSHEISSSMKAIKAICQPTDYKQECVASLKATGNNSSDPKELVQAGFKAAMKLIQAAANKSVALNQLEKDPRASKALAGCKELMDFAIDELKYSMNKLGEFDISKLDEMLIDIRIWLSATITYQETCLDGFANTTGNAAEKMKKALKTSMKLSSNGLAMVSQISSMLSELQIPGISRRRLLEIPVLGHDDYPDWANPGMRRLLAAGSKVKPNVVVAKDGSGQFKTIQEAIDQVPKRKNNATYVIHIKAGVYQEYVLVKKTLTHLMLIGDGP... | 125 |
Q9FKF3 | 3.1.1.11 | ACT_SITE 174; /note="Proton donor"; /evidence="ECO:0000250"; ACT_SITE 195; /note="Nucleophile"; /evidence="ECO:0000250" | MGYNYVSLIVTILLVVITSPVVFGNDAAPIPENKGRIEQWFNTNVKQNGRGHFKTITEAINSVRAGNTRRVIIKIGPGVYKEKVTIDRSKPFITLYGHPNAMPVLTFDGTAAQYGTVDSATLIVLSDYFMAVNIILKNSAPMPDGKRKGAQALSMRISGNKAAFYNCKFYGYQDTICDDTGNHFFKDCYIEGTFDFIFGSGRSLYLGTQLNVVGDGIRVITAHAGKSAAEKSGYSFVHCKVTGTGTGIYLGRSWMSHPKVVYAYTDMSSVVNPSGWQENREAGRDKTVFYGEYKCTGTGSHKEKRVKYTQDIDDIEAKYF... | 125 |
Q0UYX5 | 2.1.1.37 | ACT_SITE 614; /evidence="ECO:0000256|PROSITE-ProRule:PRU01016" | MLFDGFLCMGGVKHYVEGVPLNDFSIEGYGDSDDPTTATYVQSASAMKDPAYDIWYRLNEPTPAYARHHLPFLWVAQLAKHVLDFLDAKTRGSIGLDHFRSAFQPWLTARFIGQTTFDEWYHALHDRRDFRVCVNAYIDFLYQQAYNLPNSRSLLAHPLWADCMTGGLVQVEPQERIAKSTLATPDVYACFKHMYFGKVICPIALSKGVKAQQQQRSADMGFIAAATGPETTPTLHPYVQALVQVGDVVAFDPDRADKQKWRNADWEWLLHVTDVELTQNGAQRLFGLYLYRPRETNIFIAQYPRQNELFFSDNCNCDDG... | 47 |
Q4AAX7 | 5.4.99.25 | ACT_SITE 51; /note="Nucleophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_01080" | MTATNHPKLFKRPVDGVLLLDKPGGMTSNEALQRVKRLFHAKKAGHTGSLDPLATGLLPICLGEATKFSQFLLEADKSYSVKGRLGVRTASGDSESPILTERPIPKLTKRALEKTLFAFRGVIDQTPSMYSALKHKGQPLYKLARQGIEVERKTRQVTIYELTLLDWDNESIELYVHCSKGTYIRTLLDDVGEALGCGAHVVALRRLRVAHYHEDQMIKLAHLEREYDKANYTGLDRYLLPLETMVSHFPAIKLSSSTAFYLQQGQAVMVPNAPTHGFVRLRDQNDQFIGIGEILSDARIAPRRLIQKR | 218 |
Q6PCF7 | 2.3.2.23 | ACT_SITE 147; /note="Glycyl thioester intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00388" | MAESPAAEAIILPGAAAGGGVVPHLSGLQTPGTSLLTTSSVWDPSASADWDNERASTQCVLRIKRDIMSIYKEPPPGMFVVPDPHDMTKIHALITGPFDTPYEGGFFLFLFRCPPDYPIHPPRVKLMTTGNNTVRFNPNFYRNGKVCLSILGTWTGPAWSPAQSLSSVLISIQSLMTENPYHNEPGFEQERHSGDSKNYNECIRHETIRVAVCEMLEGKCQCPDALRSVMEKSFMEYYDFYEAVCKDRFHLQGQNMQDPFGEKRGHFDYQSLLSRLQTIHQRVREKHRRETVDIDSDSSSSETETDTQGSSNP | 64 |
Q4WD56 | 3.2.1.21 | ACT_SITE 446; /evidence="ECO:0000250" | MAPPDSTHGGSFRDHLKTNDRSSTSKGKQRYSPLQEAIPEEISSFRSPSEYADTDSDSDLERSGSYKLRPVDRYGSHHSSAFIPVIREENGVETYLDSITEAEQELLSASKQYDLVDDDDSSDFDSDEEATLRYRLKDRLKRRRARLQAWQPVKYARIWWRTLLAVVVTLVVVVWGFLSFAVSHREEPTVWPMVPSDSWFPSPKGGTLKHWEESYKKAQSLVRNMTLVEKVNITTGIGWQMGLCVGNTGPADIVKFPSLCLQDGPQGLRFADHVSAFPAGITTGSTWNRELMRERGVAMGREARLKGVNVLLGPSMGPLG... | 161 |
F6I7K1 | 2.7.1.11 | ACT_SITE 227; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03186" | MAAGDDECTASVGEITISPVKVQRLPHLTHYLPNLKTFPNPLDRNQFYRPSDGFYISPCDVILRQITYDLSGIFPLPPSHLAYHRAGPRKQIFFDPSMIRVAIVTCGGLCPGLNTVIRELVVGLWELYGVRQIYGIIAGYRGFYSFEPMALNPKLVEDWHKRGGSVLETSRGGFDLEKIVNSIKDHEFDQVYVIGGDGTMRGAVTIFDEICRQKLNVSIAGIPKTVDNDIGIIDRSFGFQTAVEMAQQAISAAHVEAESAVNGIGLVKLMGRSTGHIALHATLSSRDVDCCLIPENEFYLEGKGGLFEFLEQRLKQNGHA... | 84 |
A0A3B3I1N6 | 2.3.2.26 | ACT_SITE 491; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MKPNVTLNFPWGGKEVSSVCSNTCLYIMAEMEMPTQHRVFDTDDSDFESPTFQSRDLETLEQSNVDGPYEPMEADATNREHETEQGGTRFSDFIPLDFEEEEAVEEAIRRSLEEETVQVPQESRSIKTLTTEEITGIVKAHSEMVVTEGFRSIIVSRRNVWTSAIRQFRRPRFVESTDMLYVTFASDENTTEDAEDLGGPRREFFRLLVKAIFQESGAFEESPNGFIPRLNVSHVQNRVYRTIGQMMSTIIVQGGECPALLSSVVLDYLLTGRMFDIRVSPEDVADVELRDSLKTIDQATTDDDLQRAIESCESWRYQIE... | 65 |
C6XGA9 | 3.4.21.89 | ACT_SITE 44; /evidence="ECO:0000256|PIRSR:PIRSR600223-1"; ACT_SITE 105; /evidence="ECO:0000256|PIRSR:PIRSR600223-1" | MWIAKKWTCSIFGSDTLKSILQALFFAILIRTFLFQPSVIPSGSMIPTLLVGDYIIVNKFSYGYSKYSFPFSYNLFNGRIFNNQPRRGDVVVFRYPKDPSIDYVKRVIGLPGDRISLEKGIIYINGAPVVRHMEGYFSYHYKEDWSSNVPIFQEKLSNGVLYNVLSQDFLAPSSNISEFLVPKGHYFMMGDNRDKSKDSRWVEVGFVPEENLVGRASFVLFSIGGDTPFSKVWLWIPNMRWDRLFKIL | 178 |
A0A1U8EJI2 | 2.3.2.26 | ACT_SITE 780; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MQIHQTAAPVSSSFNVKSSNHQIIQIFVRLFCGKTLAIQVYPTDTVEVIHDKLLLITGIPISDQRLIYGGKQLQLDQTVSHYGIEKASELQLVGRLRSTMYPQTWKLMNDLYSLIFDFCKPEHGLFQSDVDHIMSVFSEFLSRTPGDFDLASEYLEIFIYSSVPKALVKLYTSRKIVADKCIYEIIGSYMTKSVTSIHSRYSIYITVLKFCKILGKEVEFEDNLYIFCRSSLGTIIQRLGIASCKADTKELASLQDVFPFVYQIAAQLYVELESIMKSTDSSLSVSLVDHFTAFMLPVRTVIQLQVLFDVPITFPLMKDE... | 65 |
H9GFY1 | 3.1.1.3 | ACT_SITE 171; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR000865-1"; ACT_SITE 194; /note="Charge relay system"; /evidence="ECO:0000256|PIRSR:PIRSR000865-1"; ACT_SITE 281; /note="Charge relay system"; /evidence="ECO:0000256|PIRSR:PIRSR000865-1" | MFAFWSLALLLISVARGKEVCYDRLGCFTDDIPWAGTTERPISKLPWSPERINTRFLLYTKKNPDNFQEITAIDPKTIGYSNFDANKTTRFITHGFVDQGEENWLSDMCRRMFQVEDVNCICIDWSKGSRCPYTQAANNIRVVGAEVAYFINVLVADYGYSPSKVHFIGHSLGAHAAAEMGQRIPGIKRITGIDPAQPYFEGTPVEIRLDKSDAEFVDVIHTDSAPTIPYLGFGMRAAVGHLDFYPNGGEQMPGCKKNALSQIVDIDGIWEGTRDFVACNHLRGYKYYSDSILYPDGFLGYPCAAYNLFETSCFPCPARG... | 128 |
F1QG30 | 3.1.4.12 | ACT_SITE 529; /note="Proton acceptor"; /evidence="ECO:0000305|PubMed:19429680" | MSLRESPFPNGFLEGLHAVGWGLIFPCFWFLDRLIAVCISTTLERMWRLEQECYLHPLKVVFGSILFFILFVISTPFALLGFILWAPLQAIRRPFSYHKQEQSIPMENRNARWEEMGKISFGFLTANVCLLPDGIARFNNLGHTQKRALIIGKSIVQGVTRPHIRIFVDSPSSCGTVTPSSSLIPQPNASSYGSVDASGELPDAIEVNEITPKPNCNQNSNHQKHPPRSLRTLLRDADIPMEVSALFPPSVDIVCLQEVFDKRAARKLTQALGPLYGHVLYDVGVYACHPAGSCSSFKFFNSGLFLASRFPIMEAEYRCF... | 154 |
D0ZVG2 | 2.3.2.27 | ACT_SITE 492; /note="Glycyl thioester intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01398, ECO:0000269|PubMed:24248594" | MFNIRNTQPSVSMQAIAGAAAPEASPEEIVWEKIQVFFPQENYEEAQQCLAELCHPARGMLPDHISSQFARLKALTFPAWEENIQCNRDGINQFCILDAGSKEILSITLDDAGNYTVNCQGYSEAHDFIMDTEPGEECTEFAEGASGTSLRPATTVSQKAAEYDAVWSKWERDAPAGESPGRAAVVQEMRDCLNNGNPVLNVGASGLTTLPDRLPPHITTLVIPDNNLTSLPELPEGLRELEVSGNLQLTSLPSLPQGLQKLWAYNNWLASLPTLPPGLGDLAVSNNQLTSLPEMPPALRELRVSGNNLTSLPALPSGLQ... | 66 |
G7KXH8 | 3.1.1.11 | ACT_SITE 419; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MSGGGDAKRNKRLAIIGVSTFLLVAMVVAVTVNVGFNNKKEPGEETSKESHVSQSVKAVKTLCAPTDYKKECEDSLIAHAGNITEPKELIKIAFNITIAKISEGLKKTHLLQEAEKDERTKQALDTCKQVMQLSIDEFQRSLERFSNFDLNSLDRVLTSLKVWLSGAITYQETCLDAFENTTTDAGKKMKEVLQTSMHMSSNGLSIINQLSKTFEEMKQPAGRRLLKESVDGEEDVLGHGGDFELPEWVDDRAGVRKLLNKMTGRKLQAHVVVAKDGSGNFTTITEALKHVPKKNLKPFVIYIKEGVYKEYVEVTKTMTH... | 125 |
Q7NIG8 | 2.6.1.16 | ACT_SITE 2; /note="Nucleophile; for GATase activity"; /evidence="ECO:0000255|HAMAP-Rule:MF_00164"; ACT_SITE 604; /note="For Fru-6P isomerization activity"; /evidence="ECO:0000255|HAMAP-Rule:MF_00164" | MCGIVGYIGGRTALPFLVDGLKRLEYRGYDSAGIATVGESGLELVRAKGKLHNLEEKLNGVAQSTGTVGIGHTRWATHGKPEEHNAHPHTDASGRLAVIQNGIIENYAELRLGLKERGCLFKSETDTEVIPHLIACRLAGHSLLEAVLAAVVELKGAFAIAVVSADFPDELIVVRQQAPLVIGFGEGENYFASDVPAIVSHTTRVLTLQDGECARLTRDEVQIHDFSGARLRRTPRSLNWNPSLVEKRGFRHFMLKEIHEQPGVIRDTLEDRIGDATGPIRLGLSSDLFADLERIYIIACGTSWHASLVGKYLIEELAGI... | 81 |
Q54QF1 | 2.3.2.26 | ACT_SITE 1091; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MFNLNIFGISNLINNSNNNKNKNNNNINNNNNNNNNNNNNNNNNNNNSNNNNSNNNNNNSTNTNSSIININSNSNSNNSQMELINNNSLINSSESFLVSKKKENMKSLSNDRIGSGLYSIVSGNGIVGNIGDVGEDFCFQVSSYHKNGVRKKQGGDIISVNIQGCDYQNIEEQIKSRVIDRMNGCHLVYYNVSKSGNYLISVFVNQVPVVGSPFKVFVSPIPYSICIKQKLSSPSSSSSSSSSSSFSSSSSSSSSSSSSSSSTLNNQIIAGNLITCEISPTRVSSHIINDKIDLTIFIKENGVLKKTNVEINSEILNSIN... | 65 |
Q9KST7 | 4.2.1.20 | ACT_SITE 49; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00131"; ACT_SITE 60; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00131" | MNRYQALFQRLSAAQQGAFVPFVTIGDPNPEQSLAIMQTLIDAGADALELGMPFSDPLADGPTIQGANLRALAAKTTPDICFELIAQIRARNPETPIGLLMYANLVYARGIDDFYQRCQKAGVDSVLIADVPTNESQPFVAAAEKFGIQPIFIAPPTASDETLRAVAQLGKGYTYLLSRAGVTGAETKANMPVHALLERLQQFDAPPALLGFGISEPAQVKQAIEAGAAGAISGSAVVKIIETHLDNPAKQLTELANFTQAMKKATKI | 202 |
Q7SG58 | 3.2.2.27 | ACT_SITE 166; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03166, ECO:0000256|PROSITE-ProRule:PRU10072" | MSSLKRKAGSSQPGPSPDAKKPNQNGNIMSFFGVPKPGGPLNSSSPTTRSTSRSQSQLSNSNSSTTTTATTTPDPATVTKKFNKEKWVASLTPEQRDLLQLEIDTLDESWLAHLKEEIVTKEFFDLKRFLKKEWETKTIFPPKEDIYSWSRHTPLPTVRVLILGQDPYHNHNQAHGLSFSVRPPTPAPPSLRNIFIGLARDYPSFTPPPSKSGLLTPWATRGVLLLNTCLTVRAHEANSHANRGWERFTQKVIDLVNERQKKGVVFMAWGAPAGKRMAKVDGKRHLVLRSVHPSPLSAHRGFFDAGHFKKGNEWLEGRYG... | 173 |
M4EJ94 | 2.3.2.26 | ACT_SITE 1410; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MENRGQKRMEVVGEPPADKRACNSQDFTSGASSAQAQQANGNTDADMDTSSSASPSSRSDGEQDREEEEEEESDYGSCDSDDEDPRRRVLQRYQRGRSTGDQLKLKSLASRLSEENDPSLQLTGLTELCEVLSFCTEDSLSIVMADLLSRVLVKLAKHESNADIMLLAIRAVTYLSDVYPRSVAFLVKHETIPALCQRLLTIEYLDVAEQCLQALEKISRDQPVACLNAGAIMAVLSYIDFFSTSIQRVAVSTVVNICRKLPPEPPSPVMDAVPVLCNLLQYEDRQLVESVAICLTKIADQGVIGLLRKLSSGSTLAFRT... | 65 |
Q6GNG3 | 5.3.4.1 | ACT_SITE 53; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:Q9H3N1"; ACT_SITE 56; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:Q9H3N1" | MAAAGLCFILAIVSSTSLLASVPVSALVEDLDDSFKENRKDDIWLVDFYAPWCGHCKKLEPVWNEVGIEIRTSGSPIRVGKIDATVYSSIASEFGVRGFPTIKALKGDMAYNYRGPRTKEDIVEFANRVAGPLIRPLPSQQMFDHVKKRHPVLFVYVGVESTLKEKFIEVASELIVYTYFFSASEDVLPKYVTLNEVPAVLVFKDSTYFVYDEYEDGDLSSWVNKERFEGYLHIDGFTLYELGDTGKLVAVAVIDEKNNSIEHTRIKSIAQDVAKNNRNNFHRDFQFGHMDGNDYINSLLMDELSIPTFVVLNTSNQQYF... | 215 |
Q8F352 | 3.4.21.92 | ACT_SITE 98; /note="Nucleophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_00444"; ACT_SITE 123; /evidence="ECO:0000255|HAMAP-Rule:MF_00444" | MSVIPYVIEQTSRGERSYDIFSRLLKDRIIFLGNAINDDYANVITAQLLFLEAENPERDIYLYLNSPGGYVSSGLAIYDTMQYIKPDVRTLCLGQASSMAALLLAGGAAGKRSALPNARIMMHQPMGGATGQASDIEIQAREVLKLKEILNSIYHKHTGKTVEQIQKDTERNFYMTADEAKNYGIIDTVIQIDRKQTE | 179 |
A1WIS6 | 2.2.1.2 | ACT_SITE 125; /note="Schiff-base intermediate with substrate"; /evidence="ECO:0000255|HAMAP-Rule:MF_00492" | MNQLDALKQFTTVVADTGDFKQLAQFQPQDATTNPSLILKAVQQPEYAPLLQDTVARCKGRTMDDIIDRLLVRFGCEILAIIPGRVSTEVDARLSFDTYASITRAERIIDLYQAEGIDIDRVLIKIAATWEGIKAAEKLEQRGIHTNLTLLFSFAQAVACGQARVQLISPFVGRIYDWHKKQAGAHWDEAAAAGANDPGVRSVTQIYNHYKHFGIATEVMGASFRNLGQITALAGCDLLTIAPELLARLVASAAPLQPALDAEAAKGMALPAVNYDEAGWRYALNEDAMATEKLAEGIRAFAADAVKLEQLILASG | 52 |
A0A1U8BIG9 | 3.1.1.11 | ACT_SITE 246; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MAWNNGINLLLLLLLLALCTLPSLQLQSQERKGDFEKWLSWNVRDHQKKTTLGAEATSSTGRRGARPAADLKGLDTKLKKAELNKVRVRVSQDGTGDYSSIQEALDDIPLKNTRRVILEINPGVYREKILIPRSQPFITFLGDSANPPTITGNDTASGTGRDGKPLKTFQSATVGVNADYFVAINIIFENTAPHDIGSTGEQAVALRISGNKAAFHNCSFYGSQDTLYDHKGLHYFNNCFIQGSVDFIFGYGRSLYENCYLNSISKKVASLTAQKRTNISLSSGFSFKDSVVTGSGLVYLGRAWGDRSRVIFSYTYMDKV... | 125 |
Q9W326 | 2.3.2.26 | ACT_SITE 1394; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MEPPAAPVPLQPLAASSACLADRSPVDPIAVRLQQEEQAEGDDEEEEEEEEDDDDDPKEEEAFYEARNGNESDELEQAFQSALTLTNDVHVSVSEVEEHEPPLASRNQEVAEVEEQQQQLGACALPQPSEASLTGSKETREPRHHQTLLSTKSCETPANNATLSPTNSYNGSIGSDGGSSVGGGARRKSWTLSPQSGGSTPLSGAKKKTKTGAPTTTLSNANGDGFNLWVARECFETVPAEMVDTLSMAEVDEEVDEEEDEEAAAVESLLGAAAALQASAHVQRRQQQQHHQHLRQPSPPQHRPLERSWPPRAVGRDLKL... | 65 |
A8WWF0 | 2.7.11.1 | ACT_SITE 299; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR038147-1"; ACT_SITE 316; /note="4-aspartylphosphate intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR038147-1" | MDKVEQLNLNLQNILDDVDIDSAESSLDDEEVTKQEESIENRNTEEPDYSESDYEDDEDIVDFAEATGDFTKKLNAARSNAIGPNAARNRLTVDVERHADTSEDRKRKRVKDRADRATVEQVLDPRTRLVLFRLLQRGTLLNIDGCISTGKEANVYHATGTENDLAVKIYKTSILTFKDRERYVTGEFRYRYDASVSAKRSVFRYRHGYCKSNPRKMVAVWAEKEMRNLARMHEVGLPVPKPHMLKGHVLVMDFLGKDGWPAPLLKNANLSTEEAEPMYVGLVRDMRRLYRECKLVHADLSEFNMLVHDGKLWIIDVSQS... | 99 |
Q814U0 | 2.7.1.21 | ACT_SITE 89; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00124" | MYLINQNGWIEVICGSMFSGKSEELIRRVRRTQFAKQHAIVFKPCIDNRYSEEDVVSHNGLKVKAVPVSASKDIFEHITEELDVIAIDEVQFFDGDIVEVVQVLANRGYRVIVAGLDQDFRGLPFGQVPQLMAIAEHVTKLQAVCSVCGSPASRTQRLIDGEPAAFDDPIILVGASESYEPRCRHCHAVPANKDK | 88 |
D8SF28 | 1.11.1.7 | ACT_SITE 65; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MGAKFLLVLVVVATVSSNCRVKGALDRGFYDDSCPPFEVIVSGTVQSFLDRDPSVAPGLLRMLFHDAFVGGLDGSPLLNSSGGSDPPERLATPNLSLHGFDLIDAIKSKLEGICPGIVSCADILATAARDAITLSGGPFWRLKFGRRDGRRSFFQGALKDLPSPFENTTALLKKFRNRGFSAEEMVVLQGGGHSIGVGHCPFFRDRYSNFSGTAQPDPALNPTHAIFLKASCDPNGNAAVANDHGSAHLLDNHYFLNIQKGKGLFNSDQEFYSDSRTRKSIDKYAASSEKFYLDFIKAMEKMSELGVLTGSHGSIRTHCA... | 14 |
A0A1Y1HPL7 | 2.3.1.181 | ACT_SITE 137; /note="Acyl-thioester intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR016262-1" | MAHKALQIMRLGRIPYGAGLRIQETLFSLRTQKSVPDTLLALEHPPVYTVILYPILNLHEAKIGARAYVEGLEEVMVQTAGVWGVKARGKVPAETGVWVEDRKIGAVGVRISRGVTSHGLALNATVDLGWFEHIVPCGIADKEVTSLERETGGAEVRFDDVMRESMRAFCRVFGYQHP | 55 |
A0A1D5QZE0 | 2.7.10.1 | ACT_SITE 778; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000615-1" | MGPGVLLLLLVVTAWHGQGIPVIEPSGPELVVKPGEMVTLRCVGNGSVEWDGPISPHWTLYSDGPSSVLTTTNATFQNTRTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAKEVVVFEDQDALLPCLLTDPVLEAGVSLVRLRGRPLLRHTNYSFSPWHGFTIHRAKFIQGQDYQCSALMGSRKVMSISIRLKVQKVIPGPPALTLVPEELVRIRGEAAQIVCSASNIDVDFDVFLQHNTTKLAIPQRSDFHDNRYQKVLTLSLGQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLDLSSEQNLIQEVTVGEGLN... | 97 |
Q7QK98 | 2.3.1.48 | ACT_SITE 469; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR602717-51" | MPGKVNHVSEDRWRECIVDAISFVLRQKQSATLPRISFALRKRHNLPEDTVADRLTDAVSSGWIVLRVRGQETSYRVAKQQQQQQQQQQKARKVPPPPAGVLLCIECLKPGGHSSPEPISSCDRCAIALHDACANRSNGSEADAIPLSRLVAAGNRWYCEECQPCDGCSTANESLSHPQRCVVECLDCRRRFHFQCMNPSVRLSAVQAWHCSDCIGSEHQQTVVEKIKQRQDSVKIAKGDNGARFYRSQPTEADLIGGRIEAMRLRLGDQVAGDDLDMFRDVLLMRCRLEEDDLARTPAAVRLGRYEIETWYSSPFPQEY... | 61 |
Q08BW3 | 4.6.1.16 | ACT_SITE 342; /evidence="ECO:0000256|PIRSR:PIRSR011789-1"; ACT_SITE 350; /evidence="ECO:0000256|PIRSR:PIRSR011789-1"; ACT_SITE 389; /evidence="ECO:0000256|PIRSR:PIRSR011789-1" | MTDAVFQAPKRRARVYECFEAALPVPLNSADDGDHTLLCRAEIIGHHVSVTDPAHIQQLYHRGYFGKGVFSRSRPEHMISPQWKYVGDRCLPVISLSEYQKRLSLARAALVMQDLEEESVNKALQILTEPVEFNTEEQQEPISKSNCDESLMDQTMDTDLIPDQTESAKPQRQGNPLYDPLAEIYPEKLDQSLKADEKCRDHNDWISQCGCRANEERMNRTMHKSQTYEYVLVEESEDERSQHITQENSSTDQPAELVCRINPFPMLEYLQLSYEEAFFLVYALGCLSIYYNGEALSVAQLWTMFRSLQPNFCFSYAAYH... | 207 |
P9WGC7 | 6.2.1.5 | ACT_SITE 259; /note="Tele-phosphohistidine intermediate"; /evidence="ECO:0000255|HAMAP-Rule:MF_01988" | MTHMSIFLSRDNKVIVQGITGSEATVHTARMLRAGTQIVGGVNARKAGTTVTHEDKGGRLIKLPVFGSVAEAMEKTGADVSIIFVPPTFAKDAIIEAIDAEIPLLVVITEGIPVQDTAYAWAYNLEAGHKTRIIGPNCPGIISPGQSLAGITPANITGPGPIGLVSKSGTLTYQMMFELRDLGFSTAIGIGGDPVIGTTHIDAIEAFERDPDTKLIVMIGEIGGDAEERAADFIKTNVSKPVVGYVAGFTAPEGKTMGHAGAIVSGSSGTAAAKQEALEAAGVKVGKTPSATAALAREILLSL | 247 |
O08911 | 2.7.11.24 | ACT_SITE 153; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MSSPPPARKGFYRQEVTKTAWEVRAVYQDLQPVGSGAYGAVCSAVDSRTGNKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDESLDDFTDFYLVMPFMGTDLGKLMKHETLSEDRIQFLVYQMLKGLKYIHAAGVIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKILFKGNDHLDQLKEIMKITGTPPPEFVQKLQSAEAKNYMEGLPELEKKDFASVLTNASPQAVNLLERMLVLDAEQRVTAAEALTHPYFESLRDTEDE... | 104 |
I1GU69 | 1.11.1.7 | ACT_SITE 98; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MRMRMPRSSVLSFLAVSAFVLAASVTADNYDKGGQQQQNKEACDDQYDRAYHKPAAGLVSEYYGKSCPDMERIVQAAVNRAIANDYTVAAGLIRLFFHDFAVRGCDGSILIDAPGSERHAAASKTLRGFELIEEIKAKLNARCNNTVSCADILTAATRDASMKVGVPYWSLKYGRKDGRDSHAEEADAQVPMGRERVTDLVQFFETRGLNVLDLVILSGAHTIGKASCGAVKRRVLTSKPETLDRKYGDFLLRKCHRGDDAERVELDGESPTTFDNRYYQNLERRMGLLETDQGMLEDSRTTRFVKEMAREPEVFKRQFA... | 14 |
B9IG41 | 3.4.19.12 | ACT_SITE 20; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331"; ACT_SITE 125; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331"; ACT_SITE 140; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331" | MEGESNGGMLYHEVQEAKLCAVHCVNTVLQGPFFSEFDLAALASDLDTKERQMMQEGTVSAAASGDFLSAESHNVSLGGDFSIQVLQKALEVWDLQVIASDSPVAEHAQIDPDLENAFICHLHDHWFCIRKVNGEWYNFDSLYAAPQHLSKFYLAAYLDSLKNSGWSIFLVRGNFPKEFPIASSEASNGYGQWLSPEDAERIIKSCNNTQSPQRINSTQQDSNPYQEILLEMEDQDMKAAIAASLMEPSQSMSRVETGSPQKDDEDTKDDNKDSEDKKPQ | 175 |
C5YIK0 | 3.1.1.11 | ACT_SITE 245; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MQMSAKINGAAAAAAFLLFYTHLYFPTTVHLYSSATPLLGALVNLTTPSLPLYPFSVDSTSTHHQYDCKYNPLCDDFPPDFPPPDIPAVSIFCVDPNGCCEFTTVQAAVDAVPNHSSKRNVVWINKGIYFEKVTVPASKPNITFQGQGFDLTAIAWNDTAKSANGTFYSASVSVFASGFIAKNISFINVAPIPRPGAVDAQAVAIRINGDQAAFWGCGFFGAQDTLHDDRGRHYFKECFIQGSIDFIFGDARSLYENCRLISIADPVPSGQRSITGSVTAHARVSEDDNTGYSFVNCSIGGTGWIWLGRAWRPYSRVIFA... | 125 |
G7K6B3 | 3.4.19.12 | ACT_SITE 18; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331"; ACT_SITE 132; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331"; ACT_SITE 147; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331" | MSTEKSHVYHERQRLQFCLIHTLNSLFQQKDAFTRANLNAISEKLALDESFNNESSWTPLSIFFKPHHNALTGNYDINVLTAALEEKGKSVVWHDRRKGGSSVDLDASEDVLMGVVINIAVKRFAGIWKSRHWIALRKIDGVWYNLDSDLSAPKSFRDTDEVREFLDSSIVRGGEVLLVMNQKQS | 175 |
H2MTX0 | 4.1.1.17 | ACT_SITE 356; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR600183-50" | MNTEVPTLEFSFLEEGFSAWDIVEQKINESSLTDDRDAFYVCDLGDVLKKHLRWTRALPRVTPFYAVKCNDSRAVVMTLASLGTGFDCASKTEIQLVQSLGVHPNRIIYANPCKQVSQMKYASAHGVEMMTFDSEVELMKVARYHDNAKLVLRIATDDSKAVCRLSVKFGAPIKACRGLLERAKELGLDVVGVSFHVGSGCTDAGTFVKAIADARCVFDMGEELGFQMDLLDIGGGFPGSEDTELSFEEITATINPALDKYFPVDSGVRIIAEPGRFYVASAYTLVVNIIAKKVIIDEEAPIDEEDNKTLMYYVNDGVYG... | 195 |
Q812X9 | 5.4.99.25 | ACT_SITE 38; /note="Nucleophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_01080" | MEGVVLLHKPKGMTSHDCVFKLRKILREKRIGHTGTLDPDVTGVLPICVGRATKIAQFLTSETKTYEGEVTLGFSTTTEDASGEVVETKNVDRTITRMEVEKVLAELTGTIEQMPPMFSAVKVNGKKLYEYARAGQEVERPVRTITIHEFVLLDDREVFEGENISFRFRVTCSKGTYVRTLAVMIGEKLGFPSHMSHLVRTASGEFLLEDCISFEEIEENVQNGTVESIFISIDEALSKFPKMVVDEKQAEKIKNGMFLKNELEITAPFITVFDKNDRCLAIYEHHPKHPGMLKPMKVLVNNQELKL | 218 |
A0A804HZD0 | 1.11.1.7 | ACT_SITE 65; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MRNVSVRCILICVVLSSLSCVRSDLELGFYDKSCPTAEKMIFGYVKRHVPNAPSLAAALLRMHFHDCFVRGCDGSVLINSTRKHQAEKSALPNQSLRGFDFLDRVKSLVEAECPGVVSCADIIALVARDSVVAIGGPYWNVPTGRRDGLISRSSEASKELPAPTFDFTALRSSFSSKGLNLKDLVVLSGAHTIGVSHCRSFSNRLYNFTGKGDEDPSLDSFYAADLRKNKCKTPKDTTTIVEMDPGSFRTFDLGYYKHLLQRRGLFRSDAALATDAATKSAIIQLVNSPMEVFFKEFGLSMEKMGRIEVKTGSAGEIRKN... | 14 |
B5DFP5 | 2.7.11.1 | ACT_SITE 269; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR630616-1" | MERAVKENLPSNVKVFHPTMEGPKRIPVTQPPSTQVRPPGTAVSAQRILGPSNVPQRVVSQAQKPVMSAQKPVMSTQKPMTQGPLRPVTHGHQAGKPQGPNENRTPQQTSHSSTPNVEKKGSTDQGKTLAVPKEEGKKKQWCLEDFEIGRPLGKGKFGNVYLARERESKFILALKVLFKTQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDAARVYLILDYAPGGELFRELQKVTRFDEQKSALYIKQLAEALLYCHSKNVIHRDIKPENLLLGANGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMHD... | 99 |
H3GXV0 | 4.1.1.50 | ACT_SITE 88; /note="Schiff-base intermediate with substrate; via pyruvic acid"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 102; /note="Proton donor; for catalytic activity"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 261; /note="Proton acceptor; for processing activity"; /evidence="ECO:0000256|PIR... | MTHTFPEPIKLHDDETSSTQSEASDSVPNTFEGPEKNLEIDFKHGVGHPRGFREVARADLDEMLEAGQCQILSRTSNEHIDAYVLSESSLFVYAHKVVLKTCGTTTLLKCLPFIKTFSERLGLSIEWVNYSRKNYTFPEEQKYPHTSFQTEVAFLSSYFPDGSAHVLGPLNRDHWYIYAWDADIHGEPGALTHNYALEEPGQNESTLHVLMQDMHPSVAKQFFKNNDSTLTSRRMTIESGIRDLVPGAVIDDFAFDPCGYSMNGILFDAYYTIHITPESDCSYVSFETNARLRSYQSLLKNVLRCFRPAKYSVSVYTERN... | 196 |
O43066 | 2.7.11.1 | ACT_SITE 187; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MTEVYSKAPATVGQVKLSNNGTSNKAYSVPKSPAPVRTDLFSKIPAGTKIQVGSHSVIIQRYLSEGGFSHVYLALLENEKPFVLKRIYVPDKTALQLVHGEIETMKRLKGHRHIVNYIDSSALYSKSENRYEVYLLMEFCAGGGLIDFMNTRLQHRLTEGEILKILADVCDAVAAMHYLDPPLIHRDLKIENVLLVAPNSYKLCDFGSACEPLAPATTPDTIMFLEQNIAAYTTPQYRAPEMIDINRRQGIDEKSDIWAIGVLAYKLCYYTTPFEQVGNSAILKASFSFPPFPRYSDRMKRFIATCLQEQPSHRPNIYQT... | 99 |
B8E223 | 2.6.1.16 | ACT_SITE 2; /note="Nucleophile; for GATase activity"; /evidence="ECO:0000256|HAMAP-Rule:MF_00164"; ACT_SITE 603; /note="For Fru-6P isomerization activity"; /evidence="ECO:0000256|HAMAP-Rule:MF_00164" | MCGIFGYIGNKNCIPFIISGLEKLEYRGYDSAGMAYIRNDSVLEIKKVVGKVQNLKEILDFSDFSKVGIGHTRWATHGGISVENAHPHTDCKGNIVVVHNGIIENYKELKELLINKGHVFKSQTDTEVIPHLLEEMVDKEEIGLEEAVKELFKKLEGAFALLIMDKRNPNILYALRKQSPLIVGFGIGENFIASDIPALGDYTDRFYYLKDNQMAKISANEIKVYDMGVGKYIGVEPIRIPQDRIRAEKNGYPHFMLKEIFEQPLVVRRILSTVNKNRDELQIEDIKSIDISWEKIKKVFIVACGTSYHAGYYAKFLWEE... | 81 |
P39525 | 2.3.1.41 | ACT_SITE 187; /note="For beta-ketoacyl synthase activity"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01348"; ACT_SITE 322; /note="For beta-ketoacyl synthase activity"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01348"; ACT_SITE 362; /note="For beta-ketoacyl synthase activity"; /evidence="ECO:0000255|PROSITE-ProRule:PRU0... | MSRRVVITGLGCVTPLGRSLSESWGNLLSSKNGLTPITSLPNYNEDYKLREKSIPSTITVGKIPENFQNENSAINKLLFTSQDERRTSSFIKLALRTTYEALHNAGLLNPNDITINTSLCNLDHFGCLIGSGIGSIQDIYQTSLQFHNDNKRINPYFVPKILTNMAAGNVSIKFNLRGLSHSVSTACATGNNSIGDAFNFIRLGMQDICVAGASETSLHPLSLAGFIRAKSITTNGISRPFDTQRSGFVLGEGCGMIVMESLEHAQKRNANIISELVGYGLSSDACHITSPPADGNGAKRAIEMALKMARLEPTDVDYVN... | 60 |
A0A2C9WN28 | 3.1.1.11 | ACT_SITE 397; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MLSTMYFLSARTKLLLTLLPVSVFLLILLTLPLKNSPTAEIPHLHIHKHFQIAHSACEGTLYPQLCVSTLLALPDLTSKSLPELISGTINRTMYEVGVSYSNCSGIRNKFRKIKKIENVALTDCLELFSETIDELKLALADLSTKASVSKHYHDLQTLLSAAMTNQYTCLDGFAYTRGNVRKTIKTSLYNISRHVSNSLVMLKKISGVNASKSAAFPDHGNMKRGFPSWLSSKDRKLLQAPPNATKFDLIVAKDGTGNFTTIGQAVAAAPNSSTTRFVIYIKAGAYFENVDVEKKKKMLMFIGDGIGKTVVKANRSVVDG... | 125 |
Q966Y3 | 2.7.11.24 | ACT_SITE 147; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MSSSDYYSQRVGDTVFTVQKRYTNLTNIGSGAQGVVCSAFDTVTQEKIAIKKLVKPFQNETYAKRAFRELRLMKMVDHKNIIGLKNLFTPAKSLDDFQDVYIVMELMDANLCRVIGIELDHDRMSYLLYQLLCGIKHLHSAGIIHRDLKPSNIVVKEDCSLKILDFGLARTADQTFNMTPYVVTRYYRAPEVIVGMKYKENVDIWSVGCIFAEMIRGDILLPGKDYIDQWNKVTQVLGTPPSVFFKQLSSSVRLYCESQPRYAGKSWKDLFPDDVFPNDTPEDKAKTRHGRDLLSKMLQIDPQNRITVEQALAHPYVSIW... | 104 |
Q0U6H2 | 3.1.1.11 | ACT_SITE 187; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MLSLLIVLALAVATVAAPPPPVSRAGRPSAPPGCLAVGSSSQYKTVQSAVNALSTTSTTAQCIFIAKGTYKEQVYVQALKSPLTIYGETTDTSSFSANTVTITQGKSQDDTPTNDETATLRAHTANLKVYNINLVNTRGSGSQALALSAYSGKQGYYGCQFKGFQDTILAQEGTQVYAKSYIEGATDFIFGQKGQAWFHAVDIRVLTASVGYITANGRESATNPSYYVINKSTISAASGNNVKAGTYFLGRPWRNFSRVVFQNTSMTNVINSAGWTIWNTGDPRTDNVEYGEFGNTGDGSKGTRASFSKKLSKAVAIETV... | 125 |
P11376 | 3.2.1.17 | ACT_SITE 35; /evidence="ECO:0000255|PROSITE-ProRule:PRU00680"; ACT_SITE 53; /evidence="ECO:0000255|PROSITE-ProRule:PRU00680" | KVFSKCELAHKLKAQEMDGFGGYSLANWVCMAEYESNFNTRAFNGKNANGSSDYGLFQLNNKWWCKDNKRSSSNACNIMCSKLLDENIDDDISCAKRVVRDPKGMSAWKAWVKHCKDKDLSEYLASCNL | 160 |
A0A1D6K434 | 1.11.1.7 | ACT_SITE 79; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MASKVPAALLSCAFLLLLGAACQAAAGHYSPPSPASCGLKVGYYDHKCPPAEAIVKSVVRAAVRRNPGIGAGLIRMLFHDCFVEGCDASVLLDPTPANPQPEKLGPPNNPSLRGFEVIDAAKAAVERACPGVVSCADIVAFAARDASSFLGGRRVDFDMPAGRLDGRASNASRTLDFLPPPTSSLPELVQSFAAKGLSAEDMVALSGAHTVGRSHCSSFVPDRLAVPSDISASFAASLKGQCPASPSSSDDPTVVQDVVTPDRLDNQYYKNVLAHRVLFTSDASLLTSPATAKLVDDNANVPGWWEDSFKVAMVKMASVE... | 14 |
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