Entry stringlengths 6 10 | EC number stringclasses 260
values | Active site stringlengths 0 544 | Sequence stringlengths 20 2.05k | labels int16 1 260 |
|---|---|---|---|---|
F7GAE4 | 5.4.99.12 | ACT_SITE 66; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR001430-1" | MGSVQAAGSVRARYLVYFQYVGTDFNGVAAVRGTQRAIGVQNYLEEAAERLNSVVPVRFTISSRTDAGVHALSNAAHLDVQRRSGRPPFPPEVLAEALNTHLRHPAIRVLRAFRVPSDFHARHAATSRTYLYRLVTGCHRLAELPVFERNLCWTLQADCLDVAAMQEAAQHLLGTHDFSAFQSAGSPVPSPVRTLRRVSVSPGQASPLVTPEESRKLRFWSLEFESQSFLYRQVRRMTAVLVAVGLGALAPAQVKTILESQDPLGKHQARVAPAHGLFLKSVLYGSLGAASCTLQGPQFGSHK | 217 |
A7S521 | 2.7.11.1 | ACT_SITE 192; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000605-50" | MAEVFPPDINDVALAAGEDELSSDDEFDEGQVYDEPMDGDERMETLQLSEETVNPKDEKVGPESFELLKVLGKGGYGKVFLVKKNHGHSKEKIFAMKVLKKAAIIRSQKDTAHTKAERNILECVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFLEDTACFYLSEISMALEHLHKQGIVYRDLKPENILLDANGHVKLTDFGLCKESIFENSLTHTFCGTIEYMAPEILTRSGHGKAVDWWSLGALMYDMLTGTPPFCADNRKKTIDKILKGKLIIPPYLTPEAKDFIRKLLKRHPQARLGGMAGDANPI... | 99 |
A0A2K1YJU2 | 3.1.1.11 | ACT_SITE 388; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MASSTHQPLLNTTNNTKSHVKILIFAISLFAVIFSSVFLASRLIKVSQSSPSTPQICNQARDPQECLSILSEAVSTEGVQESNGVGLLKTFLVKSLSQMRMAKAAANAVNSKINGHKHQAALADCVELMDMSIDRVTDTLSALANWGSQSDASDANTWLSGVLTNHVTCLDGIDTIDQPSMKKLLQDLISRMRTSLAAVSSLSASDTDLVQPLNGGFPSWILGRDRKLLESSVSTVEANVVVAQDGSGDNTTIQESVNSVPDKSKSRYVIYVKSGIYKENVEVGKKKKNVMIVGDGMDSTILTGNLNVVDGSTTFRSATL... | 125 |
A0A9K3DG92 | 2.3.1.41 | ACT_SITE 180; /note="For beta-ketoacyl synthase activity"; /evidence="ECO:0000256|PIRSR:PIRSR000447-1" | MAALNISPPKRETDPKKRVVITGMGVVSVFGNDVNTFYEKLLEGQSGITLIDKFDASSFTVRFAGQIRNFSSAGYIDGKSDRRLDDCWRYCLVAGRKALDDANLGPQVLETIDRTRIGVLVGSGMGGLTTFSNGVEALIQKGFKKITPFFIPYSITNMGSALLAIDRGLMGPNYSISTACATANYCFYAAANHIRRGEANIMVVGGTEAAVNPTGVGGFIACRALSQRNDEPHKASRPWDQDRDGFVIGEGAGVLIMESLEHATKRGANIIAEYLGGAITCDAHHMTDPRKDGLGISSCITKCLEHAGVSPEEVTLVQFN... | 60 |
F4NVE6 | 6.3.4.4 | ACT_SITE 40; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03125"; ACT_SITE 68; /note="Proton donor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03125"; ACT_SITE 167; /evidence="ECO:0000256|PROSITE-ProRule:PRU10134" | MSSSISTSTSDIAAATTTHAHTQSTPRPGVTVVLGSQWGDEGKGKLVDVLAQDIDVCARCQGGNNAGHTIVVNGVKFDFHLLPSGLINPACQNIVGNGVVVHLPSFFQEIETTVSKGIKVAGRLFLSSRAHLVFDFHQIVDGLKEDELGRGSIGTTKKGIGPAYSSKASRSGLRVHHLFEFEEFEASFRQMVANKKKRYGDFQYDVDAEIARYRDYAARLPEYVIDSIKFMHDQINSGKRVLIEGANALMLDLDLGTYPYVTSSNTNIGGVCTGLGIPPQKIGRVIGVAKAYTTRVGAGPFPTEQLNASGDILQTVGQEF... | 253 |
Q9RQI6 | 3.4.21.92 | ACT_SITE 98; /note="Nucleophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_00444"; ACT_SITE 123; /evidence="ECO:0000255|HAMAP-Rule:MF_00444" | MNLIPTVIEQTSRGERAYDIYSRLLKDRIIMLGSAIDDNVANSIVSQLLFLDAQDPEKDIFLYINSPGGSISAGMAIYDTMNFVKADVQTIGMGMAASMGSFLLTAGANGKRFALPNAEIMIHQPLGGAQGQATEIEIAARHILKIKERMNTIMAEKTGQPYEVIARDTDRDNFMTAQEAKDYGLIDDIIINKSGLKG | 179 |
Q9P7J8 | 2.7.11.1 | ACT_SITE 353; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MSWKLTKKLKETHLASAIGLNSGGSSFTRGLKNSTLSSTSSRKSSDEKSRKSSEDKRSPQSTVVQPGLLQVTIIEARNLKLPSGHVPANYGVSIDNSLLAPPLSNGSGHARSRSHAWWLPYIVVEFDKNEILVDALNTASLENPCWDYQATFDVSRYSKLSLNIYLRSSSSRSRNGMGNDAFLGGIKLSPSFIVNKLTDEWVPLHGGSGELRVQMLYKPNQSTPLTIDAFELLKVVGKGSFGKVMQVRKRDTSRIYALKTMKKAHIVSRSEVDHTLAERTVLAQVNNPFIVPLKFSFQSPGKLYLVLAFVNGGELFHHLQ... | 99 |
Q5U1G1 | 1.11.1.7 | ACT_SITE 71; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MGRSGGGGGGPAMLLVAAVLVAGAAVSNAQLKVGFYSKSCPTAESTVASAVRQFADADSTILPALVRLQFHDCFAKGCDGSVLIKGVGNNAEVNNNKHQGLRGLDVVDSIKQQLESECPGVVSCADIVVLASRDAIAFTGGPSFDVPTGRRDGRTSSLRDADVLPDVKDSIDVLRSKFAANGLDDKDLVLLSSAHTVGTTACFFLQDRLYNFPLAGGGRGADPSIPEAFLSELQSRCAPGDFNTRLPLDRGSEAEFDTSILRNIRNGFAVIASDAALYNATATVGVVDTYSSMLSAFFGPYFRQDFADAMVKMGSVGVLT... | 14 |
A0A078H8F6 | 1.11.1.7 | ACT_SITE 105; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MISYYKIDPPLLLYILSLFSDTKPESIEKQDRGSYSIKTMKLLHVMAAFAAMFLMGMFVSSDGQLQMNFYAKSCPKAEKIISDHIEKHIHNGPSLAAPLIRMHFHDCFVRGCDGSVLINSTSGNAEKDAPPNLTLRGFGFVERIKTILEAECSRTVSCADIIALTARDAVVATGGPWWSVPTGRRDGRISNLTEASNNIPPPTSNFTTLQRLFANQGLNLKDLVLLSGAHTIGVSHCSSMNTRLYNFSTTVKQDPALDSEYAANLKANKCKSLNDNTTILEMDPGSRKSFDLSYYRLVLKRRGLFQSDSALTTNSATLKM... | 14 |
A0A1U8M244 | 3.1.1.11 | ACT_SITE 395; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MGKLPAIIGICSVLVVAMVAAIAVGVSRAKDSDNDDAKVSTSEKAVQSICQTTDYRETCENSLSNANTTDPKELIKVGFQAAIQEIGKVIANSSTIQNAAKDPMTRQAVDNCKELMGYAIDDLKASFNQLGAFDISKLDEYVENLKIWMGGAITYQQTCLDGFMNVSSETGVKMKALLNTSQQLTSNGLAMVTDITKIIKDLNIPGMEGVSTGSKRKLMAEDGFPSWVSFKQRQLLQQNVADMKPNVVVAKDGSGKFNNINEALKEVPMKNTAPFVIHIKAGVYNEQVLVAKTMTNVVFVGDGPTKTVITGRMNFVDGTV... | 125 |
F6PVM8 | 3.1.1.4 | ACT_SITE 129; /evidence="ECO:0000256|PIRSR:PIRSR601211-1"; ACT_SITE 180; /evidence="ECO:0000256|PIRSR:PIRSR601211-1" | MGHVLEFAVLLILIVGLSQANANTVFSIFEDHHVSKVKEVNSTDKFYNRTSVSFNRTYVLKNEHHRGIKISRGVAVYNLGFQISCYYGWSYTSYTSATIAAEYGRYGCWCGYKGSGQPVDATDRCCRSHDRCYGAALSRIQLVVAPAVKSFITSYVTVCQNRTSTCVGGFDVGRRLCDCDRKLAKCLYAARTSWSFWHSGVFARRRCGANAK | 130 |
Q9KNX8 | 6.3.4.4 | ACT_SITE 14; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00011"; ACT_SITE 42; /note="Proton donor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00011" | MGNNVVVLGTQWGDEGKGKIVDLLTEDAKYVVRYQGGHNAGHTLVIDGQKTVLHLIPSGILRNNVKCIIGNGVVLSPEALIKEMSGLEDRGVPVRERLFISEACPLILPYHVALDQAREAARGKKAIGTTGRGIGPAYEDKVARRGLRVGDLFDMASFAEKLQEVMAFHNFQLEHFYKVEPVSYEAVLEQAKGYAELLTSMVIDVTNELDAARKRGDKIMFEGAQGTLLDIDHGTYPYVTSSNTTAGGVAAGSGFGPRHLGYILGIAKAYCTRVGAGPFPTELFDEVGDHLGTKGHEFGATTGRKRRCGWFDAVAMRRAI... | 253 |
E3KAQ7 | 5.3.1.8 | ACT_SITE 308; /evidence="ECO:0000256|PIRSR:PIRSR001480-1" | MSSPSPIVELIPQVQSYDWGKLGKDGSKVAEYSKHLPNFHYDPEKPYAELWMGTHSSLPSKLIDGKLLSDHLASDPAQLLGKQISNQYGSHLPFLFKVLAIGKALSIQAHPDRQLAIKLHKERPDVYKDDNHKPEMAIAITPFSGFCGFRPLNQISQYLEKVPEFATVIGQETSSRFLEAIPSDASMPSIISSTSTDQTDVKNYQAVLKELFGKLMNASSELVTEQVRKLIKRIEAEGGRDKPFGTDEELLLRLNDQFPDDVGIFCTFVLNVVRLEPGQAAFLQADEPHAYLTGDIVECMASSDNVVRAGLTPKLRDVPT... | 214 |
F7DJ54 | 2.7.11.1 | ACT_SITE 321; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR038147-1"; ACT_SITE 338; /note="4-aspartylphosphate intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR038147-1" | MNFRELVMSRAVPGQFDDADSSDSEPTAAGGTTEEGDIGENQDWNWNEGEGDELDLGEDDDFDDEDWDWDDAVGKLTKGCASAGGSNPQANRQTSNYNSAKMSTPADKALRKFENRINLDKLNLADSIINKVTEKSRQKEADMYRVKDKADRATVEQVLDPRTRMILFKMLTRGVISEINGCISTGKEANVYHASTTTGESRAIKIYKTSILMFKDRDKYVSGEFRFRHGYCKGNPRKMVRTWAEKEMRNLIRLNTAKIPCPEPVMLRSHVLVMGFIGKDNMPAPLLKNAQLSESKARELYLLVIQYMRRMYQDARLVHA... | 99 |
F0ZMN9 | 2.3.2.26 | ACT_SITE 691; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MSFENSNNNNSSNSIGNSKSNDTVEKEKERLRFIISQYFQQITKGCGEKISHHSEYCCHNPNFQKILDPTQAAMKSLKLGKDYQEKYLCSYLYSSTAEKLIITNRYMKTLVDLSSNAKNYSNIVDFIVNYFSTPSSIITSFKSEKKQDYDDETYFEGLDINDINQIFSLLTGLNNKKVDESLKSATRLLSNNLKYNSVSYKEKEQLKPLVFLLANDFIHDLDNRTILSNVFVAFSLLQDPMKDVIIKWYNSLSKEYFIKTIINYEQFISVRIMSDEVDLHKDPAIKGACSALQLLSKINDLKRYVPFTDFYNDAINEDLD... | 65 |
A0A9R0JKG8 | 3.1.1.11 | ACT_SITE 253; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MISLKYASFVLLISVGLSLNSTNYLSNYPPLLSLKHIYKVAPNINMMLSRHHGHGSHNHHHHHHHHHHKDKDDHQNITVNICDDFPPDFPPADTNLTSILCVDSKGCCNYTTVQSAVDAAPLLSQKRVIIWINSGLYYEKVMVPKNKANITFQGQGYASTAIVWNDTANSAHGTFSSASLEVFGPNFVAKNISFMNVAPIPSPGAVGAQAVAIRIGGDLAAFWGCGFFGAQDTLHDDRGRHYFKDCYIQGSIDFIFGNGRSFYENCALISIASPIPAGQRNINGVVTASGRGSEEEKSGFVFYNCSIGGTGRIWLGRAWR... | 125 |
P08761 | 1.8.4.11 | ACT_SITE 48; /note="Cysteine sulfenic acid (-SOH) intermediate"; /evidence="ECO:0000305|PubMed:30529269" | MSLTITSSVTHPELKDLSTVRNEQKELNISPVHDVNVTKATATFGMGCFWGAESLYGATRGVLRTTVGYAGGSSDLPTYRKMGDHTEVLEIDYDPTVISFKELLDLFWNNHEYGLTTPIKRQYASLILYHDEEQKQVAHASKLEEQERRAPEIITTEIASKENFYPAEAYHQKYRLQGHKDLASSLNLSPKLLQTSYVATKLNGYLAGVGGIEQFKAEAETMGLTPTQRQYCYYHVEQNEGQGLYC | 39 |
B9ICS9 | 3.1.1.11 | ACT_SITE 358; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MATKFGLSVLFISFCSLFSPTLSSITSNEIDSWCNKIPHPEPCKYSMKQNPNPFIPNQEFESRKVAIELALKSALTAQNHHQRLWPTLRNEKEKNAWKHCLNFYNKTIDELILALDSNIKSTNFDTQTWLSAASTYLECCKDTINDLGVSDSMLPLMMSNNVSKLITNSLALHNKASSVFPQTYQDDLPTWVKASDRKLLQEPSPSPDLVVAQDGSGDYSNIKAALEAAEKSSGNGRFVIYIKSGVYKEYLEIGKKLENIMLVGDGMTKTIITGNKRSGGGVDTFHTATVGVDGHGFIARDITFQNTAGPQNHQAVALRS... | 125 |
Q61152 | 3.1.3.48 | ACT_SITE 229; /note="Phosphocysteine intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00160, ECO:0000255|PROSITE-ProRule:PRU10044" | MSRHTDLVRSFLEQLEARDYREGAILAREFSDIKARSVAWKSEGVCSTKAGSRLGNTNKNRYKDVVAYDETRVILSLLQEEGHGDYINANFIRGIDGSQAYIATQGPLPHTLLDFWRLVWEFGVKVILMACQETENGRRKCERYWAREQEPLKAGPFCITLTKETTLNADITLRTLQVTFQKEFRSVHQLQYMSWPDHGVPSSSDHILTMVEEARCLQGLGPGPLCVHCSAGCGRTGVLCAVDYVRQLLLTQTIPPNFSLFQVVLEMRKQRPAAVQTEEQYRFLYHTVAQLFSRTLQDTSPHYQNLKENCAPICKEAFSL... | 149 |
P36003 | 2.7.11.1 | ACT_SITE 580; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MFTSQRQLRQNGSPMSSSRSSQHSSGTASPISDSPASNRSYGRDLRGLMGIDIPANEPAFNRANSSDTIYFRPKKIYKMEHEHPSRSTLVQLQTRSQPDDVASSQVNPEGGTDDLELGDPCGNQSLYTIGAEYVPDLDFTKLVNEWQKSTEDLYEFRSSATPQVQIKDSGKGNYELWSSPDAILTQNKLRRDSFSQENSDSLSPEDSILSRNLHSKVKPIPLPRNSQQIFTPLSNLEAERRSSYTTSSNNNSITQNNKFSFAKLKYSLPTQSSAVPASFDSNASSLNFLPTTTLSTLSELQISPNDMMDLIQKLPRNFLN... | 99 |
A7REY1 | 1.1.1.205 | ACT_SITE 341; /note="Thioimidate intermediate"; /evidence="ECO:0000256|HAMAP-Rule:MF_03156, ECO:0000256|PIRSR:PIRSR000130-1"; ACT_SITE 439; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03156, ECO:0000256|PIRSR:PIRSR000130-1" | MASSPSKSAPKADYLISGPTSYVPEDGLTANALFGGGQGLTYDDFLILPGFIDFSADVVELNSALTREITLKTPFVSSPMDTVTESAMAVAMALHGGIGIIHHNCSIEFQADEVKKVKKYKQGFINDPLVLSPRHTVKDVIEIKKKNGFSGIPLTENGCMGGVLAGIITSRDIDFLGPEQIDEPLSEFMTPLNDLVVAKDDCTLQEANRILQQSKKGKLPIVNENGELVSLIAYSDLRKNREFPLASKDSKKQLLVGAAIGTRAEDKLRVEALIHAGVDVIILDSSQGNSAYQIDMIKNIKELCPRLQVVAGNVVTACQA... | 3 |
Q9AK82 | 2.7.7.7 | ACT_SITE 106; /evidence="ECO:0000255|HAMAP-Rule:MF_01113" | MRTAPTILHLDMDAFFASVEQASKPSLRGKAVVVGGLGPRGVVATCSYEARVFGVHSAMPMGQARRLAPHAAYLVPRFELYRSISEQVMRLLRELSPLVEPLSLDEAFVDLDAGGAARDAETARLAGTKLRTDIRTVTGLTGSVGLAASKMLAKIASEAAKPDGLVLIPPGTERAMLEPMTVRTLPGVGPATGDHLRRAGITTVGEIAEAGEDELVRLLGKAHGHALYAMALARDERPVVAERETKSVSVEDTYDVDIHDRVRVGVEVGRLADRCVRRLRASGLSGRTIVLKVRRYDFSTLTRSETLRGPTDDPAVVREA... | 121 |
A0A022QTH9 | 3.4.21.89 | ACT_SITE 130; /evidence="ECO:0000256|PIRSR:PIRSR600223-1"; ACT_SITE 180; /evidence="ECO:0000256|PIRSR:PIRSR600223-1" | MISLQLRLLHPLPSLQNPNDISFNSCSKPIIHFNQIHSKSLFKSYNRNKRLTLHCSNGSNKETTAKETRSGGGGGGGGGGDDGETEKSSGPLPEWLNFNGDDAKTVIAALVISLAFRSFVAEPRFIPSLSMYPTFDVGDRLVAEKVSYYFRNPCPNDVVIFKSPPVLQQVGYTDEDVFIKRIIAKEGDTVEVHDGKLIVNGVVRSEDYILEAPKYEMTQIRVPEKSVFVMGDNRNNSYDSHVWGPLPSKNIIGRSVFRYWPPNRIGGTVLAESCAIDKETATSTDQAVAK | 178 |
A0A2I4FMK9 | 3.2.1.21 | ACT_SITE 188; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR617736-1"; ACT_SITE 392; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR617736-1" | MVKKKDYLKEYEAADASKNDISRSDFPPNFVFGVATSAYQVEGACKEGGRGPSIWDAFSHTEGKIVDKSNGDSAVDQYHRYKEDVELIAKLGFDAYRFSISWSRIFPDGLGTKVNDEGIAYYNNVINALLEKGIQPCVTLYHWDLPLHLHETMGGWLNKQIVKYFAIYAETCFASFGDRVKTWITINEPLQTSVNGYDAGIFAPGRREHSLTEPYLVSHHQILAHAAAVSIYRNKYKDKQGGQIGLVLDCEWAEANSDKMEDNSAAARRLDFQFGWFLHPICYGEYPNVMHERLGERLPKFSEEDKELIRNSIDFVGLNH... | 161 |
A0A3B6ET60 | 1.11.1.7 | ACT_SITE 125; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MIDRAPCQPDKIHGECTRAYKNPRTPPTSTQAQPQPQPHPTITMASSSSPSAARALLVLAAAALVLSYVSAAAGAGDSPPLAKGLSFDFYSAKCPQAEAIVFAFLKDAIRKDVGLAAALLRIHFHDCFVQGCDGSVLLDKTNGVDSEKVSPPNVTLRPSAFKAINDIRALLQRACGGPVVSCADIAALAARDSVHLAGGPRYAVPLGRRDGLAPASLDTILGALPPPTSKVPVLLSFLAKIGLDADDLVALSGAHTLGIAHCGSFEERLFPKEDTTMNKWFAGHLKLTCPRLKVDNSTANDIRTPDVFDNKYYVDLLNRQ... | 14 |
Q5AK53 | 2.7.1.11 | ACT_SITE 378; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03184" | MPSSSDAINRISYISLVTSDNDKFNQTFQFYSQLGFRLTKSFSKVSSYGSGLGANHPEFQLGVSHDSLKEVWLESYPLQNVDSNGNLRPWQEMEVYDGDNCERLNESTVIKVRLLGETPLKSISQKQFVFFTTQLNKIEKILTDANVKYGKVVDNVILAEDPLSNIISFSNTQNELCKTRFQSPEEYVEKTTAEILAKRKKSQLGSKFGSFEEISPSEVGGGNGLRKKKIGVMTSGGDAPGMNPAVRAVVRAGIYYGCDVYAVYEGYEGLVKGGDLLKKMEWSDVRSYMSLGGTSIGTARCKEFRERAGRLQGAYNMIKN... | 84 |
H2MDC6 | 2.7.10.2 | ACT_SITE 279; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR630220-1" | MGESYMYQRLPYARGEGEGDEEEERSRSVGGKMMQCEEGTEWLLELLTDVQLQQYFLRIRDELNVTRLSHFDYVKNEDLEKIGMGRPGQRRLWEAVKRRRALYKRKSWMSKVFPVKRLDSDSPQTFPSGAASLAGPAGSEPGASLTCLIREPELQLLERLGDGTFGVVRRGEWTAPNGRVLSVAVKCLKTGVLDSDGLDDFIREVNAMHSLNHQNLIRLYGIVLTQPMKMVTELAPLGSLQDRLRKRQGHILILLLCNYAIQVACGMAYLEKRRFLHRDLAARNVLLSSNEAVKIGDFGLMRALPSHTDHYIMEEGHKIP... | 98 |
T1G8W6 | 6.3.4.4 | ACT_SITE 23; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03125"; ACT_SITE 51; /note="Proton donor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03125"; ACT_SITE 151; /evidence="ECO:0000256|PROSITE-ProRule:PRU10134" | MCEHANKTVGSKAIVILGTQWGDEGKGKIVDLLSQSAHVVCRCQGGNNAGHTVVVNGVMYDFHLLPSGLLNPDCLNVIGNGVVIHLPGLFDEIEKNESKGLTNWHDRLFVSSRAHLVFDFHQAADSMEESGKGQNQIGTTKKGIGPAYSCKAARSGIRVCDLIHDFCLFSERFKWLANLYMQRYPTLKVDIDSELKRYKEFRDRLAPLVRDTITFLSNEFRQPNRRIIVEGANATMLDIDFGTYPMVTSSNCSVGGVYTGLGIPPHVVGKIYGVAKAYCTRVGRGVFPTEMDKKTDEIVRKRGNEYGVTTQRARRCGWFD... | 253 |
Q83DK5 | 4.1.1.17 | ACT_SITE 326; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR600183-50" | MYAKMKLQTITSIAESRPIQPVFAFRPAALGRAVNYFCTQFDGRVLYAVKTNPEKHVIQAVHAHGVTAFDVASYEEIRIIKEYAPGAELYFMHPVKSPHAIREAYFEYGVRHFSLDCLEELHKILRHTENAKDLCLHLRLAIPNTFAEFNLAEKFGINLHEAPELLKQLRKAAYQLGVTFHVGSQCMHPDAYRIAIRMADKVINEAQVEIESFNVGGGFPSIYPGMIPPALTIYFEAIHDEFAKVAQRHPGIQLLCEPGRSLVAESTSVIVNVELRKDDILYINDGTYGSLFDAGIPHFIFPVHLLRPKHTADVDLLPFS... | 195 |
T1EDH7 | 2.3.2.26 | ACT_SITE 1681; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MLEARGLPTHLFGALGSRMQQLLQRSMAGGPVHKAQQHLQAIQSKDSSQQLQGVIEMCQILVMGNEDTLAGFPIRQAVPTLAGLLRNPTNSSGLPMASSSNHDAPIGNFDLMHHACRALTYMMEALPRSVGVVVEVVPAFLEKLQSIQCMDVAEQSLQALDMLSRKHHKAILHADGVSACLTFLDFFSITAQRTALSITANCCQNLTVEEFMFIKPSLSVLVNRLSQSDKKSLDSVCLSLSRMVDSYQSETNILRDLAADKFFEYIIQLMMASPTIISSNMFVTVIHMLVVMATSCPDLAVQLLKLNIADTLCHLLIGGS... | 65 |
Q2UCU3 | 3.2.1.23 | ACT_SITE 200; /note="Proton donor"; /evidence="ECO:0000305|PubMed:23688418"; ACT_SITE 298; /note="Nucleophile"; /evidence="ECO:0000305|PubMed:23688418" | MKLLSVAAVALLAAQAAGASIKHRLNGFTILEHPDPAKRDLLQDIVTWDDKSLFINGERIMLFSGEVHPFRLPVPSLWLDIFHKIRALGFNCVSFYIDWALLEGKPGDYRAEGIFALEPFFDAAKEAGIYLIARPGSYINAEVSGGGFPGWLQRVNGTLRSSDEPFLKATDNYIANAAAAVAKAQITNGGPVILYQPENEYSGGCCGVKYPDADYMQYVMDQARKADIVVPFISNDASPSGHNAPGSGTGAVDIYGHDSYPLGFDCANPSVWPEGKLPDNFRTLHLEQSPSTPYSLLEFQAGAFDPWGGPGFEKCYALVN... | 163 |
Q8BW96 | 2.7.11.17 | ACT_SITE 144; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MARENGESSSSWKKQAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIAGDTALSKNIHESVSAQIRKNFAKSKWRQAFNATAVVRHMR... | 101 |
E9FZB6 | 2.7.10.1 | ACT_SITE 221; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000615-1" | NNQSPIEEQVEFLPYDRRWEFPRSRLKLGSFQIGVGCFGRVVKAEAVGLKGSEETVKTVAVKMVRSEANVSAMEALISELKILVYLGSHLNVVNLLGACTKQIHKELLVMVEYCRFGNLQTFLINHRNNFINLVDEFGNLKTQDEMEREKMPSQVETSELQPDDHPGVNSSSEILDISNSTQQHLDGNLDRPISTTDLISWAFQIARGMDYLVSKKVLHGDLAARNILLADDGVAKVADFGMAKKMYYEENYEKRGQGLMPVKWMAIESLVDRIFSSQSDVWSYGVVLWEIFSLGQVPYPGMDVGHILMKEILRGYRMDK... | 97 |
Q9UB00 | 3.2.1.45 | ACT_SITE 256; /note="Proton donor"; /evidence="ECO:0000250"; ACT_SITE 361; /note="Nucleophile"; /evidence="ECO:0000250" | MILNISVSLLIFLAFYGFSSDAKSLPCSEVKKEYGIVCRCNATYCDTIEPLGTVTSGKAVVYTTSRNGKRMNRSELKHTTSSTAKTKVYVNTTQSFQPVMGFGAAFTDAAGINMKMLPQTMQDQIIQQYFSDDGLGYVFGRVPMASTDFSTHEYSYDDVKFDFDLKNFNLTVEDLQYKIPFIKKAMTASGGKLKLFATPWSSPGWMKTSGRMVGAGELLGDQNGKYYQTWAQYFVKFFEAYHAQGIDFWSLTPQNEPTTGIDPLWKWQTLFFDASMERNFIKKLLGPALASSPVTKNLKIMINDDQRINLPHWPNVILTD... | 168 |
Q5TT05 | 5.1.3.3 | ACT_SITE 237; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1"; ACT_SITE 404; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1" | MSSSSAEGNGSPDNNNSRPSGASVTIKSIDSKVEQRGSVTESYEMVDTGKSAPPVTLTVDGFGTVKHPKTGATETVKRFTWQNTDGMSVQVISYGAIITVMKVPDRNGRVDDVVLGFDDIPGYQTPNNPYFGATIGRIANRVGGGRFTLNGQEFQVTKNFDKRHQLHGGKIGFDKYNWEAFVDGTAVTLTHTSPDGDEGYPGAVMVSVRYELKADNRFEALFKAASTKPTPINLTNHSYFNLAGHATGHEEIYRHVVSINADKITDTDADSIPSGKFICVGGTPYDLRIPRELGPAMAKTVGKGFDDNFCLTKGTEQGRT... | 211 |
Q9USM5 | 3.4.19.12 | ACT_SITE 288; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093"; ACT_SITE 806; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093" | MASTATQNASTRYSQIWIDQPASLPFQDSINLIKEDKEKWKKEKTAFLIDYDWFEGYVDFIYGEGDNPGPITQWRLLDEKNELKHSLEESIDYSIVSASLWHMLVEWFGLEGLAIERKVLLVGLAAEQKPFVDIYPINFTLHVLFDPINGENTSYSPLYQIDEPYHSDEPYAFSFSRSDTLRSLYKQVMEAFQISDGTSFRLWYLNKSNLSSRFVSLSEFNDQPAIALLSEYAVCMTIFEIDIADGSLLLEFQHPNGEWLSDSITKEQNLTINKEIGLCGLYNLGNSCYMNSALQCMIHTHELTKYFLSDSYEKDINYNN... | 175 |
Q9FH09 | 3.5.1.98 | ACT_SITE 148; /note="Proton donor/acceptor"; /evidence="ECO:0000250|UniProtKB:Q8GXJ1" | MASLADGGKRRVSYFYEPMIGDYYYGVNQPTKPQRIRVTHNLILSYNLHRHMEINHPDLADASDFEKFHSLEYINFLKSVTPETVTDPHPSVSENLKRFNVDVDWDGPVFHNLFDYCRAYAGGSISAAAKLNRQEADIAINWAGGMHHVKKDKASGFGYVNDVVLAILELLKSFKRVLYIEIGFPHGDEVEEAFKDTDRVMTVSFHKVGDTGDISDYGEGKGQYYSLNAPLKDGLDDFSLRGLFIPVIHRAMEIYEPEVIVLQCGADSLAGDPFGTFNLSIKGHGDCLQYVRSFNVPLMILGGGGYTLPNVARCWCYETA... | 184 |
A0A803SKZ9 | 2.7.1.11 | ACT_SITE 235; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03184" | MLVIYGGGAGVLTLKGNSRRLQGTLRVSQAEQPVWRATRRQQRTKHQLLHQLHLRHFVCLLIFPAQRMAHVPGKHEHADTMGIGKAIAVLTSGGDAQGMNAAVRAVVRVGIYTGAKVFFVHEGYQGLVDGGDNIREATWESVSMMLQLGGTVIGSARCKDFRDREGRLKAARNLVKRGITNLCVIGGDGSLTGADTFRAEWSGLLQDLVKTGGITAEEAKNSSHLNIVGMVGSIDNDFCGTDMTIGTDSALHRIMEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTALASGADWVFIPESPPEDDWEEHLCRRLTETR... | 84 |
A0A251U2T4 | 4.1.1.50 | ACT_SITE 67; /note="Schiff-base intermediate with substrate; via pyruvic acid"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 81; /note="Proton donor; for catalytic activity"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 230; /note="Proton acceptor; for processing activity"; /evidence="ECO:0000256|PIRS... | MSAIGFEGYEKRLEITFFEPSIFADPQGQGLRALSKAQIDEILNPAECTIVSSLSNEYLDSYVLSESSLFIFPYKMVIKTCGTTKLLLSIPPILRLAESISLTVRSVRYTRGSFIFPNAQSYPHRSFTEEVSVLDAHFEKLGLSSKAYVMGGFDKPQKWFVYSASAGPVSVRDQVYTLEMCMTSLDREKASVFYKTESSSATTMTNESGIRSILPKSEICDFEFDPCGYSMNSIEDGAISTIHVTPEDGFSYASFEAVGYDFNEVSLEQLVQRVLACFEPGEFSIAVGADVASKRLEATCAIEVEGYSVEEKSYEELGCE... | 196 |
A0A804JIT2 | 3.1.1.11 | ACT_SITE 251; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MQCSASTMAITNRGTSLLVLLSAIVAALLSSQLVFQHPPCLEWLLNLDFLSFTSSISPNSYGSGHHRRHRAPKTNDTDICDDLPPGFPPADTDTTSIFCVDRNGCCSFTTVQSAVDAVAVLSQKRSIVWINKGIYYEKVTIPKTKPNITFQGQGLYTTGIAWNDTANSSHGTFYSASVAVFGANFIAKNISFINVAPIPNPGDVGAQAVAIRVGADQAAFWGCGFFGAQDTIHDDRGRHYFKECHIQGSIDFIFGDGRSLYESCQMISIASPVAAGLKTIDGTVTAHGRASGDENTGFSFVNCSIGGTGRIWLGRAWRPF... | 125 |
G1KFN5 | 3.2.1.35 | ACT_SITE 168; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR038193-1" | MSPKLRSGGVTHNVETLCSAGPSQRTSIHLRLHKHFLLLLLLFPDLPAASYNLKPSLPPIIKNNPFLVTWNAPTARCSAAYEVPLNLDSYGILVNSQEAFAGGNITIFYYDQLGLYPYYLDTTVPPTAVNGGCPQNSSLTEHLDKMKSDIGNIIPSESFAGLSVIDWEHWRPQWIRNWDKKMIYRNMSLQLVRKWSPNLSDPQAEMKAKWEFETAAEKFMLDTLRLSQSLRPNGWWGYYLFPECYNYQYLENFANFTGHCPPLEVERNNKLIWLWENSKALYPSIYMEEVLRTSLQGKRFVWAKMGEAMRVAELPSTQHS... | 166 |
A5YVX6 | 3.2.1.52 | ACT_SITE 403; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001093-1" | MKPGELKRVLFFFSFCCILFFIYLYWQQTSNLTTSKLLYTYRQPYPRQKKSHPPQWTWQCINQRCERRHIKGAIPVVSLSTCSMLCGSTQLWPQPTGPVTLASRAVTFNHQQLELETDTPEPARTLLEHSFVAFNTNIISLVQNKDYVERDTDIRRFLIKVTILHPNIVKLKLDTSEGYTLSVKPRDGEIVANITAKTFFGARHGLETLSQLIWWDDYETKGALKVLKGATVQDNPIFPYRGIMLDTARNYMSVESIRRVLDGMAANKLNVFHWHLTDSQSFPLVSQRVPQLAKNGAYGPDMIYTPEDVKALVEYARIRG... | 170 |
F6RPW8 | 2.3.1.48 | ACT_SITE 263; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR038084-1" | MEDIQNKLMPYICDANSAVQFKLVKSKEDLETDDGFFFPDMSHQIFGEKEQIFGFTDLKLRIYYTASSLQIHTKLLYGRKINPEQFDGVKADDIMKSVREVLPANVIENVDDFSKKLDGEPNFKPFGEIIYNYTRQQKGKSTKRNFEIYKADMTNPNFKEYHQRIESFILWFIDAACFIDSDDDKWDFYVVFEKCTEGGITSHLFVGYSTCYRFYAYPDKIRPRISQVLVLPPYQRQGHCTELITAIYQQYVPKAAVLDITAEDPSENFQRVRDFIDSKNCLKLPEFQDSKLGQKFSKEMRKAAQEKYKINRRQARRVYE... | 61 |
A0A8I3RS05 | 3.1.3.16 | ACT_SITE 336; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR033096-1" | MAMAEGERTECAEPPRDEPPADGALKRAEELKTQANDYFKAKDYENAIKFYSQAIELNPSNAIYYGNRSLAYLRTECYGYALADATRAIEIDKKYIKGYYRRAASNMALGKFRAALRDYETVVKVKPHDKDAKMKYQECNKIVKQKAFERAIAGDEHKRSVVDSLDIESMTQCLLLLCLRSWELHSSTPPRFARVCVPWFRRAIEDEYSGPKLEDGKVTITFMKELMQWYKDQKKLHRKCAYQILVQVKEALSKLSTLVETTLKETEKITVCGDTHGQFYDLLNIFELNGLPSETNPYIFNGDFVDRGSFSVEVILTLFG... | 144 |
A0A804KAA2 | 3.1.1.11 | ACT_SITE 388; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MLSSRVLLVFLLLPLAAAAAPPASVSPAAACRSSFYPKLCIALLSPLRFPSNQYEYGRYSVKQALKQARRTATILDRYLSGSSGGARAHRAVGGGGALEDCRELAGLNAEYLAAVQAELGRGARMLDAAGVGRVRALMSAVVTNQQTCYDGLEASREFPELQGALADQTQLYGVSLGLVTTALGRRAVPGVGTNAGSDSRTGTTGDQSSPPKGFPAIGRILVEGDREIVPVNASQSVTVAKDGSGNFTTVGDAVLSAPNDTSADGGYFVIYIGEGVYHENVIVPINKKNLILIGSGINRTIITSNRNVADRWTTFNSATF... | 125 |
A0A1U8KJP8 | 3.1.1.11 | ACT_SITE 221; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MEYNCSLVTVVVVFLCGFRVCFSLTSEVHVKNFISWDDIKVDEHQTRLSDSRVNHNRSRVIVVNKNGGADSLTVQGAIDMIPENNTRRVKIYILPGIYREKVTVPKCKPYISFVGNAGQMSNTIISWNDKASDKDSNGINLGTYRSASVTIESDYFCATDITFENTVVQTPGEPGMQAVALRISGEKAMFYKVKVVGTQDTLLDEIGSHYFYQCHIQGSVDFIFGKSRSLYQDCVIESTAVRSGAIAAHRRDSPDDDTGFSFVNCKINGTGRIYLGRAWGNYSRAIYSNCYFDNIINPAGWTDWNDPLRQKTVVFGEFQC... | 125 |
M4ESJ2 | 3.1.1.11 | ACT_SITE 290; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MVNEARTRSNEVRDKAHFADCKEMMDVSKDRMVSSMEELRGGNLNLESYSNVHTWLSSVLTNYMTCLDSISDVSIDSKHRVQPKLEDLVSRARVALSIFVSVLPSKDYLEMILPIHFPSWLNSLDRKLLESAPKTFEVKANVVVAKDGTGKYKTVNEAVAAAPENSNSRYVIYVKKGVYKETIDIGKKKKNLMLVGDGKDVTIITGSLNVVDGSTTFRSATVAANGDGFMAQDIWFQNTAGPAKHQAVALRVSADQSVINRCRIDAYQDTLYTHTLRQFYRDSFITGTVDFIFGNSAVVFQNCDIVARKPGAGQKNMLTA... | 125 |
A9UY64 | 5.1.3.15 | ACT_SITE 169; /evidence="ECO:0000256|PIRSR:PIRSR016020-1"; ACT_SITE 270; /evidence="ECO:0000256|PIRSR:PIRSR016020-1" | MASTPTQKKALQDGVTETTVTGTGGHPCPVVELRRGDAKATVHLYGATVTSWTIKSEEFLFLSSKAVLDGKKAIRGGIPLVFPEFGAWKLGPNHGFARVSLWELCDSGTTVAGDVTATFRLTDNEETRAMWPHGFELLYTVALSDHRLTCTLRIRNTGTEAFGFKTLLHTYFRVPHISKVAVHGLQGHVYRDQAEDITIYMNAVGATTVRNVARSRPVTKEDHSSATPSTDMLIAKANLPDTVVWNPWIEKAKAMGDLDDEEYKEFVCVEAGAVAQDQLLPGGESMEFGQVLTVSRRR | 210 |
O42777 | 3.2.1.28 | ACT_SITE 466; /note="Proton donor/acceptor"; /evidence="ECO:0000250|UniProtKB:P32356"; ACT_SITE 670; /note="Proton donor/acceptor"; /evidence="ECO:0000250|UniProtKB:P32356" | MDDSALPSNTSNGINGRTAHRRSSSGGDPFQHPDIYYGNPESVERIKNRRRAFSSSLKSFNRQDFHEMLGDRNTRRGSMDPTSGNPRKFLIDVDATLHSLLEREDSDRNMQITIEDVGPKVFSLGTAASHGYNRFDVRGTYMLSNLLQELTIAKDYGRKQIVLDEERLSENPVSRLSRLIKNSFWNSLTRRIDGRNIEVAGRDPKDWTDDPRPRIYVPPGAPEQLEYYRRIAEEKPELRLDVQELAAEITPEYVRDLNEKPGLLALAMEEKYDEKTGKTDFAGVPFVVPGGRFNELYGWDSYMESLGLLASNRVDLAKAM... | 165 |
G3RQJ8 | 2.7.10.1 | ACT_SITE 1124; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000620-1" | VATTGAPGSAPDPSDASTMRLLTCLAFCSFSLLVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDNEECGDICPGTAKGKTNCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHSECLGNCSQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCQDLHHKCKNSRRQGCHQYVIHNNKCIPECPSGYT... | 97 |
Q0JMF9 | 3.4.21.92 | ACT_SITE 156; /evidence="ECO:0000256|PROSITE-ProRule:PRU10085"; ACT_SITE 181; /evidence="ECO:0000256|PROSITE-ProRule:PRU10086" | MEAAAAMAALPASPCSSSSSPSSLFLAPNPCCWKAAPRATVRASASAARRTLSSAWELPGPSAARPAARKPRLEELDTTNMLLRQRIVFLGSPVDDMSADLIISQLLLLDAEDKTKDIKLFINSPGGSITAGMGVYDAMKFCKADISTVCFGLAASMGAFLLAAGTKGKRFCMPNARIMIHQPSGGAGGKVTEMGLQIREMMYEKIKINKILSRITGKPEEQIDEDTKFDYFMSPWEAKDYGIVDSVIDEGKPGLVAPLAGAVPPPKSRVWYLWNASGPTRKIMKNLPSEEKLIQNGNGSASGDDGKFKEISTA | 179 |
A0A2I2YTU5 | 2.3.2.31 | ACT_SITE 431; /evidence="ECO:0000256|PIRSR:PIRSR037880-1" | MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDNPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDEETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGA... | 67 |
A0A8J0TUN2 | 3.4.21.92 | ACT_SITE 163; /evidence="ECO:0000256|PROSITE-ProRule:PRU10085"; ACT_SITE 188; /evidence="ECO:0000256|PROSITE-ProRule:PRU10086" | MALGHVTAHGYRLSWRRSELLPDATSGTAEQGNMEQLFMRGTRPLLKGICALTQLRNVHCGPPMLSPLIPIVVEQTGRGERAYDIYSRLLRERIICVMGPIDDSLSSVVVAQLLFLQSESNKKPIHMYINSPGGSVTAGLAIYDTMQYILNPICTWCVGQAASMGSLLLAAGSSGMRHSLPNSRIMIHQPSGGARGQATDIAIQAEEILKLKKMINEIYAKHTHQPLSVIESVMERDRYMSPTEAQEFGILDKVLVHPPQDGEDEPELVRKKETPESEP | 179 |
B7QMY2 | 2.7.10.2 | ACT_SITE 567; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000615-1" | MCAASAARSPESRLRQDRGIGDQASVELQSPASPADLAPGGDLSLRCRVDGVPEPQLEWFHNGVRLFRSERLSFRGRRMHLASLTAADNGIYSCRATSEAGEVDSQTNFALVLEGENVPRISVLPGDVTVRREATARLDCVYDGAAVTEWYARDGDVPLTNSSKVTILPNSSLLVHNVQDADGGLYRCVGVSEDKNAPQQSFVARLRLALPPSVTSHPLDLVVDEGEDTALVCAFTGSPHPVTHVSWHHGERPLREPSPHATFHPNGTLVLRHVGLTDAGEYRCQVNTTGFPPETAKVATITVRGSEGYSSGSLPGVGDP... | 98 |
A0DPM0 | 3.5.1.98 | ACT_SITE 164; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR037913-1" | MQLIVLKSQQQNSQTLFGRMNLFKQKVTYYYDEEFGTYNYSTTHPMKPLRVAITDDLVGHYGLKQYMNCIDQSFVQTYIKRVDEDVLTQFHSYEYIDLIKIITPENKCQYEDQLYRFNFMEDCPVLDRLFDFCLCQTSGSVGAACVIADQKSNIAINWSGGLHHAKQSEASGFCYVNDCVLGILELLKTYQRVLYVDIDIHHGDGVEEAFYLTDRVMTCSFHKFKEYFPGTGHIDDVGHDKGKYYAVNFPLNEGLNDDSIQHIFKPVIDKIMENFRPDVVMLQGGTDSLSGDRLGCFNLSIKGHGTCIEYLKKFNVPIIM... | 184 |
B9RT46 | 1.11.1.7 | ACT_SITE 65; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MAKIVILLIYFLPTFFISSALSAQLKKGFYQKTCPLAETLVRSTVKNALASDAGIPAALIRLHFHDCFVRGCDASILLNSTPGNKAEKESMGNKGVGGFEVIDEAKAKIESYCPNTVSCADIIAFAARDSVLLSGGTYYDVPGGRRDGTTSLISEVTGNLPDSFFNATQLKQNFANKGLSLEEMVTLSGAHSIGDSHCSSFSKRLYSFNATYSQDPSLDPVYASYLKIKCPRHVKPGLPDPVVPFDPLTPTRLDSNYYKNLKNDKGLLFSDQVLWNSELTKKIVNRNIRHPNKWASKFAAAMGHMGSIEVITGSQGEIRK... | 14 |
Q8CVD2 | 3.2.1.52 | ACT_SITE 565; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR625705-1" | MSKTIAATAILFALGLSACSQGPKTVNTPAPSSAEQPTPALLTQAQLQQFGDNLGVTYRVLTNRPDDNCDKAAAEGRCFVAEIDFVPEVDLIGKEWAIYFSQMRPVQSVEGKEFSITHIKGDLYRIAPTEAFSGFSKGVKKTLRFRGELWQLSETDAMPNYYIVAGDLSPVVIASTQVKQDPETRMEVRPYVEPFTDMVKQYSRTDADKLAPATASQLFSNNQNVSEDASLAVNTIIPTPKTVVLHSNDKVVSLSSGIKLDVASVSSPSAEKQSFKTDQVAAALERLARLGVKESEQGLVMKLSWRQGAEGSYLLDIKPD... | 170 |
Q43348 | 3.2.1.26 | ACT_SITE 120; /evidence="ECO:0000255|PROSITE-ProRule:PRU10067" | MASTEALLPVTSLQDPLSESRSDQIPETRRRRPIKVHLAVYSGLLLIALYVTLIVTHDGSKAEIATESRPRMAGVSEKSNDGVWISSDDGKVEAFPWNNTILSWQRTAFHFQPEKNWMNDPNGPLFYKGWYHFFYQYNPNAAVWGDIVWGHAVSKDLIHWLYLPIAMVPDQWYDANGVWTGSATFLDDGSIVMLYTGSTDEFVQVQNLAYPEDPSDPLLLKWVKFSGNPVLVPPPGIGAKDFRDPTTAWKTSSGKWRITIGSKINRTGISLIYDTTDFKTYEKHETLLHQVPNTGMWECVDFYPVSKTQLNGLDTSVNGP... | 164 |
Q9HV51 | 5.3.1.1 | ACT_SITE 95; /note="Electrophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_00147"; ACT_SITE 167; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00147" | MRRPLVAGNWKMHGTHSSVAELIKGLRQLALPSGVDVAVMPPCLFISQVIQGLAGKAIDVGAQNSAVEPMQGALTGETAPSQLADVGCSMVLVGHSERRLILGESDEVVSRKFAAAQSCGLVPVLCVGETRAEREAGKTLEVVARQLGSVIDELGVGAFARAVVAYEPVWAIGTGLTASPAQAQEVHAAIRAQLAAENAEVAKGVRLLYGGSVKAASAAELFGMPDIDGGLVGGASLNADEFGAICRAAGS | 213 |
E3KPE1 | 3.1.1.11 | ACT_SITE 207; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MAPPIAIYILFSLLFISHICVSSYVPSEISQPKRRQENFPSSTIPPPGSLVVRQTNAKQGDYNTISAAVNALKTLKGPQVIFIGPGTYHEQVHIKYKYPLRIQGYSSDPNSLTGNQVTVQVAVSAASHNGENAPSSAIWVQSPRFEMHNVNVINSFGTGTDTQAVALTAQGEKHVYKYCLFTSYQDTLLIKAASSYFYGCRVEGAVDFIFGSGSAWFEMADIVVKPPKHFATITAQRRAQGGNTMFVFNKSKVLPFSQDTQPNSVYFGRPWSPYSAVTFQSCYLSNIINPLGWIPWNESSDPRTQHVTYQEFNNYGPGSP... | 125 |
A0A1D6L4K3 | 1.1.1.205 | ACT_SITE 320; /note="Thioimidate intermediate"; /evidence="ECO:0000256|HAMAP-Rule:MF_03156, ECO:0000256|PIRSR:PIRSR000130-1"; ACT_SITE 416; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03156, ECO:0000256|PIRSR:PIRSR000130-1" | MASSSPDLADDGFAAPRLFSQGVSYTYDDVIFLPGYIGFPADAVDLSTRLSRRVPLSIPCVASPMDTVSEAAMAAAMASLGAAAVVHCNTEPHSQAAIVRAAKSRRLPFVSSVPFFSPSSSPTLNDFAGSEYALVTERGDSLSRLVGIAVAADAASREVPISVSEYMRPTPRSASSAFDFEEAATFLADEGLDYAPLVSDDGEVVDLITAKDVERIRSYPKLGKPSLGANGKFVVAASIGTREDDKGRLEQLVKAGANAIVIDSSQGNSIYQLDMIKFAKKMYPEVDLIGGNVVTIAQAQNLIQAGVDGLRVGMGSGSIC... | 3 |
H2LF92 | 3.2.1.35 | ACT_SITE 139; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR038193-1" | MFLWTLSDFKVHLLIVTLWDNLCALGLKPTQWPLYPQKPLLLVWNAPTQECGPWRQVFFQLDQFHIVATPNEGFVRQNLTMFYKDRLGLYPYLELDEMAVNGGLPQVASLTKHLEKMEEGVRRYIPEADARGLAVIDWEEWRPIWMRNWGPKHIYRNHSLALVQQKNPTWPLEQVNRVAQQEFELSAKKFMLETLRRAKHLRPNKLWGFYLFPDCYNHDYLRSMVSYTGRCPDVEVARNERLEWLWTESTALFPSIYMGAVLRSTASGRQFVRNRVKEGMRLASSGDGLARPVFVYTRPTYINSLEQLTEADLVSSIGES... | 166 |
A8Y4M0 | 3.2.1.23 | ACT_SITE 213; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR006336-1"; ACT_SITE 296; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR006336-1" | MNLWTTWLFITLNLLISTNGLVRTSYGNWNLERIGDGNTPSFLIDESKNQFLLDGLPFRYISGSIHYFRIPRERWEERLGKVRALGFNAIQYYIPWNAHELEEGNHDFSGILDFAEFSSMAFHKYNLWTILRIGMIFMVNNFQIKIPGPYICGEWENGGLPAWLLNKNVTKQRSSDPVFTREVEKWFETLLPRVKPLLRKNGGPVLMLQIENEYGSYGVCDKQYLRFLRDLTRAHVGDDVLLFTTDGASEKLLKCGTVEGVFPTVDFGPTDNKKDIESYFQIQRKYAPNAPFVNSEYYPGWLVLWGQKRQDLPSPQTIIN... | 163 |
A0A022RML7 | 3.4.21.92 | ACT_SITE 166; /evidence="ECO:0000256|PROSITE-ProRule:PRU10085"; ACT_SITE 191; /evidence="ECO:0000256|PROSITE-ProRule:PRU10086" | MEGGILTFTASSSAHPAALLRRSATIFTPPRDSFRQFSTTSKISNGKKSSRKIGNFSVKASNNSLSSNWEVSNYAAPAWLPRFEELDTTNMLLRQRIIFLGSQIDDVTADFVISQLLLLDSENPKKDIKLFINSPGGSVTAGMGIYDAMKMCKADVSTICMGLAASMGAFLLASGTKGKRFCMPNARVMIHQPLGTAGGKATDMSIRIREMAYHKVKLNKILSRVTGKPEEQIELDTDRDNFMNAWEAKDYGLIDVVIDDGKPGLVAPIGDKSAPPKTRVWDQWKIEGSRKAKKNLPSEDKMLLNGQNGGTEQKEEAPTP... | 179 |
A7F4A8 | 3.4.21.92 | ACT_SITE 92; /evidence="ECO:0000256|PROSITE-ProRule:PRU10085"; ACT_SITE 117; /evidence="ECO:0000256|PROSITE-ProRule:PRU10086" | MLATRGGGWRTSDIFSKLLQERIICLNGEVDSSLSAAVVAQLLYLESDAPEKAITLYINSPGGSVTAGLAIYDTMTYIKSPVSTVCVGQAASMGSLLLCGGEPGKRFCLPHSSIMIHQPSGGYSGQATDIAIHATEILRVRKSLNEIYKRHLTKEHSLEEIERMMERDKFLSAQEALDMGIVDEILDRRESVGKKEYS | 179 |
Q1QZV1 | 2.2.1.2 | ACT_SITE 131; /note="Schiff-base intermediate with substrate"; /evidence="ECO:0000255|HAMAP-Rule:MF_00492" | MTQLEALKQLSMVVADTGDLEAIKRYQPHDATTNPSLILKAFELPGYQALIDETLAQVKADIADPQARVDEAVDRLSVAMGSEITQLIPGRVSTEVAAKLSFDREASIAKAHRLIELYEQRGIGRERVLIKLASTWEGIRAAEQLEKEGIQCNLTLLFSEAQARACFDAGVYLISPFVGRVTDWYKQKTGQEYTPEEDPGVVFVRKVCDIASRYRYDTVVMGASFRTKGQILGLAGCNRLTISPALLEELESEEGDIERKISDVGDASERLAPIDEAAFRWGLNQDAMATEKLAEGIRRFADDQATLEEKLAARLG | 52 |
W1PZW6 | 1.11.1.7 | ACT_SITE 66; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MAAIYMLLLVLVRSVQGSSNSTKPELSVDFYSKSCPQLEQLVLSVTTQQFKQAPSSAPATIRLFFHDCFVQGCDASVLITTRGGSGVEVEREAYDNKDLAAEGFESVNKAKALVESKCPGLVSCADILAIAARDFIHLAGGPNYLVKKGRRDGKASTIANVKGNVPRSNATVDQLIRLFGSKGLSIPDLVALSGAHTIGFSHCDQFVGRLYDYRGTGHPDPVLDPRLLKALRMSCPRFGGNTDVVAPFDVKTPFAFDHMYYANLQTNLGLLATDQALFLDPRTKPIVQALGKDIGAFFKAFALGMDKMGSIGVKMGAQGE... | 14 |
A9A3X2 | 3.1.26.11 | ACT_SITE 64; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_01818" | MKLVFLGTSAAQPTENRGLSCICLEREGEVLMFDAGEAAQISYMKSGLGWNKKMKIFVTHLHGDHCVGILGLLQTMSMQNRTESLEIFGPSGIEEFIAANIKVLNFGLSFPILINTIKDEKIFEDEKFLIRTCKANHSIIAFSYLFEEKDKPGRFNVEKAKELGIPEGELWNKLQNGNEITVNEKIIKPEQVLGERRPGKKIGISGDTMPTKELEEFFEECDYLVFDSTFLEAEKQKAQDTCHSTAKQAATVAKNAKVKNLVLTHFSARYRDEVEHLREAKEIHDSVITAKDLLEIEIK | 137 |
A0A9J7KPC8 | 2.7.11.23 | ACT_SITE 146; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR637770-1" | MMGHILCSGKIKMAADRSKRYQKIDFLGEGQFATVYKAKDTKTGQIVAVKKIKLGQRAEAKDGINRTALREIKLLQELSHTNIIGLYDVFGHKSNISLVFDFMDTDMEVVTKDTSIVMTGPHIKAYAIMTLEGLEYLHNNWILHRDLKPNNLLVNSQGILKITDFGLAKTFGSPNRVYTHQVVTRWYRAPELLYGARIYGTGVDMWAVGCILAELLLRVPFLPGDSDIDQLSKIFQALGTPSEDTWPGMKSLPDYIEYKQFPGTPLKDIFTAAADDLISLLGKLLCLNPSQRYNCSQALQMPYFSNKPGPTPNPQLPLPS... | 103 |
Q8AAQ1 | 2.7.1.25 | ACT_SITE 109; /note="Phosphoserine intermediate"; /evidence="ECO:0000255|HAMAP-Rule:MF_00065" | MEEKNHIYPIFDRMMTREDKEELLGQHSVMIWFTGLSGSGKSTIAIALERELHKRGLLCRILDGDNIRSGINNNLGFSETDRVENIRRIAEVSKLFLDSGIITIAAFISPNNDIREMAANIIGKDDFLEVFVSTPLEECEKRDVKGLYAKARKGEIQNFTGISAPFEVPEHPALALDTSKLSLEESVNRLLEMVLPKIEKK | 90 |
A0A8V0YA90 | 3.2.1.143 | ACT_SITE 714; /evidence="ECO:0000256|PIRSR:PIRSR607724-1"; ACT_SITE 732; /evidence="ECO:0000256|PIRSR:PIRSR607724-1"; ACT_SITE 733; /evidence="ECO:0000256|PIRSR:PIRSR607724-1" | MSAGCGRDHPCKRARLSPGGGSQGEQRPPPPDSGPEGPGGGSSVTAVGNKACKQRTITTWLEDKGPKTTESRSLQSKINNNTEENTKMTSVKKENVCEHDVKQLENICQQNCPEVSGEVGTKHVNLSQTGSICNWEAEGRDPVSDRVPVKAEQTGEAFKNANIDQMHRTGKEAQRRCEESGDIWTQRKRSSGQSLKTGNTKPSSKDTETDGQVVLCNSQKLKSCDPVDTGEQEEGDVVPESPLSDTGCDACVSRVGGPEKLSKCRSSSGDSPAFEKESEPESPMDVDNSKNSCHGSEADEETSPLLDEREENNMAKSINK... | 159 |
A0A8V0YKP8 | 2.7.10.1 | ACT_SITE 989; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000615-1" | MSRNAGLAEDEFFEKPVLSIAKDHIVILPGEDLKIKCRGARPVSWLLGEAQRKDPRVDISSCRNNSRQSCSTLLLRNVTASDTGYLTCVHDDAPSREELTAKIYVFVEDYRNPFVEFYPEHPQIIYLLEAKKTVVIPCRVTSPDIRPQLMQYPHREKLKFKKMVWDPKRGFVIPSPAFTYSGVLTCTAGINGSVFTSYYLVQKLEDRVQNLALKATPKKLLVGETLYLECKAETFINGRIEFIWTCPNGKHPYPRRGMDRSKPVYKFGSSLTIENVTMEDGGLYICRTFNLTSLEANVTVTVYDKPFLEVSHKKGLYYEI... | 97 |
Q8H129 | 3.1.3.2 | ACT_SITE 255; /note="Proton donor"; /evidence="ECO:0000250" | MTYIYRDTKITTKSTIPFLIFFLFCFSNLSMATLKHKPVNLVFYVYNLIIIFSSHSSTAELRRLLQPSKTDGTVSFLVIGDWGRRGSYNQSQVALQMGEIGEKLDIDFVISTGDNFYDNGLTSLHDPLFQDSFTNIYTAPSLQKPWYSVLGNHDYRGDVRAQLSPMLRALDNRWVCMRSFIVNAEIVDLFFVDTTPFVDKYFIQPNKHVYDWSGVLPRQTYLNNLLKELDVALRESVAKWKIVIGHHTIKSAGHHGNTIELEKHLLPILQANEVDLYVNGHDHCLEHISSVDSNIQFMTSGGGSKAWKGGDVNYVEPEEM... | 145 |
A0A2R6WNQ1 | 3.5.1.2 | ACT_SITE 139; /note="For GATase activity"; /evidence="ECO:0000256|PIRSR:PIRSR036936-1"; ACT_SITE 244; /note="For GATase activity"; /evidence="ECO:0000256|PIRSR:PIRSR036936-1"; ACT_SITE 246; /note="For GATase activity"; /evidence="ECO:0000256|PIRSR:PIRSR036936-1"; ACT_SITE 295; /evidence="ECO:0000256|PIRSR:PIRSR036936-1... | MAAAKCAEIACSGSLWCNGGADSAALHRRELGSVRISGSRCRGHNLGLVTALAAEDISDNEVTLLDYGGGNVQSIRNAIKLMGFNIKNVHSPKDIESAKRLIFPGVGAFAAAMDVLESRGMADPLKDYIRQDRPFLGICLGLQLLFDFSEEHGHVEGLGLIPGAVSRFEATNGLRVPHIGWNGVKLRYPSDLLEGVNGRHVYFVHSYRAVPSEANNDWVLATSNYGGEFVAAVKKGNVHAVQFHPEKSGVVGLDILRRFLDGGRSSDAERVAHLASQHNSHPASSLAKRVIACLDVRSNDAGDLVVTKGDQYDVREAGDG... | 181 |
Q9QXX3 | 3.1.1.4 | ACT_SITE 74; /evidence="ECO:0000250|UniProtKB:O15496"; ACT_SITE 119; /evidence="ECO:0000250|UniProtKB:O15496" | MLLLLLLLLLGPGPGFSEATRRSHVYKRGLLELAGTLDCVGPRSPMAYMNYGCYCGLGGHGEPRDAIDWCCYHHDCCYSRAQDAGCSPKLDRYPWKCMDHHILCGPAENKCQELLCRCDEELAYCLAGTEYHLKYLFFPSILCEKDSPKCN | 130 |
I1GRV7 | 1.11.1.7 | ACT_SITE 66; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MAANKLAILISLALLSSLAAFHCHALQVGYYRDTCPNAETLVRAHIKKALRSDPGNGAGLIRMLFHDCFVNGCDASVLLDPTQTNPRPEKLGAPNNPSLRGYEAIDAAKSALELACPGVVSCADVVAFAARDASYLLSHGRVSFLVPAGRLDGRVSRENDTQFLPGPSSNLTTLVGSFAAMGMSVEDLVVLSGAHSIGRSHCSSFVQDRLNASSSSSPAPAADMSAPLASFLRRRCPASVPVAGVKDPTVAQDVVTRDVLDNQFYRNVLARRVLFASDAALLEEVDAGRMVRANARFPASWERKFARAMVKMAAIGVKGP... | 14 |
P28191 | 3.1.3.48 | ACT_SITE 952; /note="Phosphocysteine intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00160, ECO:0000255|PROSITE-ProRule:PRU10044" | MRLGSNSYDVQRTEAIGQTPVKTPPPNQIRCTVTFLDSTSYHFEIEKNSLGIVLLEKVFNYLEIIEKDYFGLVFIAVDNSSAQQKKWLDPSKNLRKQMICPPYHLFFRVKFYVRDPNRLRDEFTRFQFYQQVRQNLEEGRLPCNEGSLALLASYVVQAEVGDFEEKTHGMSRTCLCYKIQFATLPDDFSDRVAELHQLHIGQTPDVAEQNFLDHARRLEMYGMDVYDGVDANHLPIEIGVGAVGIKVFHEGIKMNEYAWVRIRKLSFKKKQFQVLVANEDGVSETIMIFNIMSAKICKLLWKCCIEQHTFFRLKTPPKTP... | 149 |
A0A8J1M2P1 | 3.2.2.27 | ACT_SITE 154; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03166, ECO:0000256|PROSITE-ProRule:PRU10072" | MIGQRTINSFFGAAVKKRAASTVWDGEDSCKAGEVRAQCKAGETTPVKKSRPSNENDIPSAVSPPLSPEQLERMQRNKAAALQKLAARHAPQGLGESWKQELLAEFAKPYFVKLSNFIAEERKKCTVYPPPEEVFTWTQMVDIKDVKVVILGQDPYHGPNQAHGLCFSVKKPVPPPPSLVNMYKELETDIEGFSRPGHGDLTGWAKQGVLLLNAVLTVRAHNANSHKDCGWEQFTDVVVSWLNKNMDGLVFMLWGAYAQKKGSNIDRKRHHVLQTVHPSPLSVHRGFFGCRHFSKTNAYLQGLGKKPIDWKAL | 173 |
P47670 | 5.3.1.1 | ACT_SITE 93; /note="Electrophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_00147"; ACT_SITE 160; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00147" | MRTRYLIGNWKTNKNLKDAVSFVEQFQQNKLNYNAKIGIAPVYVHLTEIKKIISDSLLLFAQDANFIESGSYTGTVSFTQLQDIGVNNSIIGHSERRKYYNETSAVINQKLFACLKASMQVVLCIGEALGQEISFLKTDLTNCLDTIDKSLIKNLVIAYEPLWAIGTGKTATPEVANQTIKTIREYINDLYDENVANNISILYGGSVDHNNIQKLAIMEQIDGFLVGKASLEIKNFLEMARVYA | 213 |
A0P8X0 | 3.2.1.1 | ACT_SITE 231; /note="Nucleophile"; /evidence="ECO:0000305|PubMed:22819817"; ACT_SITE 373; /note="Proton donor"; /evidence="ECO:0000305|PubMed:22819817" | MTRKTRYLHQITTLILGGLLIVPAAAPPVSADIAATHVYHNHMPNFWAYYDLNTYNSTPVGSPIRYTYDGEVIQLKQNPPAGYPYYLPNGSPMPHDDLVSYYSHHAKTGAYLTWPWSVANTLHSSHPQAQMHVTMSGSVVNNVNSIIQQGNVSGYNNPAWGTPWKNAVTQLKTAGGDNRLDLIHFSGHHSMGPLVGNDYLLKDMIYHGATMAQPYFLGSSYKSSKGFFPTELGFSERIIPVLNKLGIQWSVIGNNHFSRTLKDYPLLDSPGTDTMISPPNRSDLQNVSTAGAWVNEPMFNEQQVVYNKYPFASTAHWVRY... | 157 |
Q5KKV0 | 4.6.1.16 | ACT_SITE 249; /evidence="ECO:0000256|PIRSR:PIRSR017250-50"; ACT_SITE 257; /evidence="ECO:0000256|PIRSR:PIRSR017250-50"; ACT_SITE 288; /evidence="ECO:0000256|PIRSR:PIRSR017250-50" | MSPPPHSIPLYLVNGVATVWDAQTAATLHCVHNVSGLRAGTLPGVAQQNGFLGLPLTLMQEETAYLVTQGIAHLVPLDPSPSPPSDETVKAHTAARVARLKALEEKTREAEAKRLEESKKAFDKGGEKARLKREARARAKAEKAKESGEGLFAEDVKENVTAPIVVSPAKTKTKHAGAPAAGHFHIVPSHPVLSQHPPESQSITSLPHPLFPFPTTPRQCALLGVFSKLQSLSYRVGLGPRFGGEWLIYPGDYLRYHAHFTSQVIVRDEPIRPTEIVAWGRLGTGTKKAGLICCWDDGKREDGQDDQGGKEEDVEFYSLE... | 207 |
A9WFY1 | 2.3.1.286 | ACT_SITE 123; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_01121" | MNDLDDVITILATALSTARHVTVLTGAGVSAESGIPTFRDAQTGLWSHFDPEELASPAGFARNPALVWRWYAERRVKACTAQPNPAHHALADLATLVPRLTLVTQNIDGLHQRAGSPQVIELHGNIHRARCTVDGSIHTTWDYDEELPQCPNCGALLRPDVVWFGEYLPPGALEAAYAATLDCDVFCSIGTSGVVEPAASLPRIALSRGATVLILNLEQTTTARSPLFTVYGKAGEVLPRLVAAVRSMRRQQGE | 58 |
A0A803TSP8 | 2.4.1.18 | ACT_SITE 341; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR000463-1"; ACT_SITE 396; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR000463-1" | MAALMGSLVPELQRLLEKDPYLAPFEQDFQRRYGIFHHILKSVEESEGGLDKFTKSYLTFGVNRFVDGGIYCKEWAPGAEAVFLTGDFNNWNPFSHPYKKMDFGKWELFIPPGPDGFSPVSHGSKLKVVIRTRSGEVLYRISPWARYVAREGTNVNYDWIFWDPPNPYRRRHPVPKKPKSLRIYESHVGIASPEGKIASYKNFTHNVLPKVKDLGYNCIQLMAVMEHAYYASFGYQITSFFAASSRYGPPDDLKELIDVAHSMGITVLLDVVHSHASKNSEDGLNNFDGTDNAFFHSGTRGVHALWDSRLFDYANWEVLR... | 73 |
Q3UFF7 | 3.1.2.22 | ACT_SITE 125; /note="Charge relay system"; /evidence="ECO:0000250|UniProtKB:O75608"; ACT_SITE 180; /note="Charge relay system"; /evidence="ECO:0000250|UniProtKB:Q5VWZ2"; ACT_SITE 212; /note="Charge relay system"; /evidence="ECO:0000250|UniProtKB:Q5VWZ2" | MAAVPSAVHLPRCVVSPTGRHSASLIFLHGSGHSGQGQREWIKHVLNQDLTFQHIKIIYPTAPSRPYTPLKGGLSNVWFDRFKISMDCPEHLESIDSMCQVLSGLIDEEVKTGIQKSRILIGGFSMGGCMAMHLAYRSHPDVAGVFVLSGFLNKASVVYQDLQQGGRMLPELFQCHGSADNLVLHAWGKETNSKLKSLGVSTTFHSLPNLNHELNKTELEKLKSWILTRLPGETDGQSE | 134 |
A0A251VJA1 | 1.11.1.7 | ACT_SITE 69; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MTNSKAVALAVGFMILLNLTGHCYGALEFGFYNGKCKLSDVEDIVRRTVYSKFLKDRTIAPALIRMQFHDCFVNGCDASILLDGPNAEKTAPPNLSVRGYNVIDDAKAAVEKVCPEVVSCADIIVMATRDVISFSGGRRYSVQTGRRDGRVSLARNTQTLPPPSASVSSAIRAFARKGLNPTDMLYLLGGHTIGIAHCSLFQDRLYNFQNSGKPDPTMDATLIASLRKTCAQNATLDRTVNLDQNPLSSKVIDKSFYNQIMLRRGILQIDQQLALDGLTKSKVAAIAASSDFNTKFGQAMVKMGAIQVLTGTQGEIRKSC... | 14 |
Q7NCF0 | 1.8.1.4 | ACT_SITE 441; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000350-2" | MAFDYDLLIIGCGVGGHGAALHAVAHKLKVAVVEARDLGGTCINRGCIPSKALLAAAGRLRVLRESEHLGISVGEISFDRAKIAHHAASVVDKIRADLTKSLQKLGVTILHGHARLKGSQTVEIDPGEGGGEVQVLTARDVLIASGSQPFVPPGIVTDGKTVYTSDEGVRLEHLPEHICIIGSGYIGLEFSDVYTALGTKVTMIEALDRLMPGFDPDIARLAARLLVKSRDIDTKVGVFAKKVTPGQPATVELSTGEQLQFDAVLVACGRTPDTKNLGLESVGLETARGFIPVDGRMATSAEHLWAIGDATGKMMLAHAA... | 36 |
O23044 | 1.11.1.7 | ACT_SITE 66; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00297, ECO:0000255|PROSITE-ProRule:PRU10012" | MNCLIAIALSVSFFLVGIVGPIQAQLQMNFYANSCPNAEKIVQDFVSNHVSNAPSLAAALIRMHFHDCFVRGCDGSVLINSTSGNAERDATPNLTVRGFGFIDAIKSVLEAQCPGIVSCADIIALASRDAVVFTGGPNWSVPTGRRDGRISNAAEALANIPPPTSNITNLQTLFANQGLDLKDLVLLSGAHTIGVSHCSSFTNRLYNFTGRGGQDPALDSEYAANLKSRKCPSLNDNKTIVEMDPGSRKTFDLSYYQLVLKRRGLFQSDSALTTNPTTLSNINRILTGSVGSFFSEFAKSMEKMGRINVKTGSAGVVRRQ... | 14 |
A0A3B3HEC3 | 3.5.1.98 | ACT_SITE 833; /evidence="ECO:0000256|PIRSR:PIRSR037911-1" | MFSTAPVSRLHEQPKHELSQSSRKADRSHRLSGNAFVDVSPAALPSQVPPTSTAILPMDLRVVDHHHHQQQPAFGLVSQPHPSPAPGCPASEGGHGPVVGHQEHQLQHELVALKHKQQLQRQLLIAEFQRQHEQLSRQHEAQLQEHIKHQQDLLALKHQQELLEHHRKMEQQRHDQLEKQQREQKLQQLKNKERGQESAVASTEVKMRLQEFVLNKKKALAQRNLNHCLPSDLRYWYGKTHHSSLDQSSPPQTALSAYNHPMLGTYDLKDDFPLRKTASEPNLKLRSRLKQKVAERRSSPLLRRKDGLITTAKKRSLDVA... | 184 |
A0A9R1V3Y8 | 1.11.1.7 | ACT_SITE 75; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MSMTNSKIVLLAVGVIFFNLVGHCYGSLGYGGLQYGFYNGKCRTSDVEDIVRRTVYSKYLTNRKIAPALIRMQFHDCFVNGCDASILLDGPNTEKTSPPNLSVRGYDVIDAAKAAVENVCPGVVSCADIIVMATRDVVSFSGGARYSVQTGRRDGLVSLAQNALTLPPPTSSVSSAIRAFALKGFTATDMIYLLGGHTIGIAHCSLFKDRLYNYKNTGKPDPSMDLSLLSSLKSKCPQNTTADPTANLDQNPFSSAVVDKSFYSQIIMGRGVLQFDQDLASDRLSKSTVAAIARSSDFNARFGQAMVKLGATQVLTGKQG... | 14 |
P27932 | 3.2.1.1 | ACT_SITE 207; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:P00693"; ACT_SITE 232; /note="Proton donor"; /evidence="ECO:0000250|UniProtKB:P00693" | MGKQMAALCGFLLVALLWLTPDVAHAQTQILFQGFNWDSWKKQGGWYNMLKDQVGDIASAGVTHVWLPPPTHSVSPQGYMPGRLYDLNASKYGTKAELKSLIAAFHAKGIKCVADIVVNHRCADDKDGRGVYCIFKGGGPRGCLDWGPSMICCDDTQYSDGTGHRDTGADFAAAPDIDHLNPLVQRELSDWLRWLRRDVGFDGWRLDFAKGYSAAVARTYVQNARPSFVVAEIWNSLSYDGDGKPAANQDGQRQELVNWVKQVGGPATAFDFTTKGILQSAVQGELWRMRDKDGKAPGMIGWYPEKAVTFVDNHDTGSTQ... | 157 |
Q6DRD9 | 3.1.1.116 | ACT_SITE 142; /note="Charge relay system"; /evidence="ECO:0000250"; ACT_SITE 238; /note="Charge relay system"; /evidence="ECO:0000250"; ACT_SITE 297; /note="Charge relay system"; /evidence="ECO:0000250" | MSNFAMSALCRVFTRGAPCGLSSCSSVTGLRDFCSGVSRLDRAGSDSMRTASPVNLTYDVFDGKGDSTPLVFLHGLFGSKSNFHSIAKSLVQRTGRKVLTIDARNHGKSPHSPVLTYDTMTSDLTHLLGQLHIGKCVLIGHSMGGKVAMTTALSQPNLVERLVVVDISPSLTSAHTNFHAYIQAMKEVKIPSDIPRSTARRLAEDQLRKIVKERSVRQFLLTNLEEQNGQYGWRINLESISNHLEDILGFPEFDTTYEGPTLFLGGSSSAYISSDDYPEIQRLFPCADIQYIPDASHWIHADKPLDFISSIITFLQP | 126 |
Q9FII5 | 2.7.11.1 | ACT_SITE 852; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MKKKNISPSLVLHPLLLLLLPFFAFNSLALKFSPQLLSLLSLKTSLSGPPSAFQDWKVPVNGQNDAVWCSWSGVVCDNVTAQVISLDLSHRNLSGRIPIQIRYLSSLLYLNLSGNSLEGSFPTSIFDLTKLTTLDISRNSFDSSFPPGISKLKFLKVFNAFSNNFEGLLPSDVSRLRFLEELNFGGSYFEGEIPAAYGGLQRLKFIHLAGNVLGGKLPPRLGLLTELQHMEIGYNHFNGNIPSEFALLSNLKYFDVSNCSLSGSLPQELGNLSNLETLFLFQNGFTGEIPESYSNLKSLKLLDFSSNQLSGSIPSGFSTL... | 99 |
A0A3B6I0Q5 | 3.1.1.11 | ACT_SITE 202; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MCSTMFASLALLLAQFCATSLLFSAASTMPDCHSKIPANFPPPDTMSTSVLCVDPSGCCRFTKVQRAIDSIPENSSKRTILWINKGTYFEKVRVTKPNITFQGQGLMDTFIVWNDTAKTSSGTTSSGSVDIKAAGFIAKNISFKNSAPVPKPGDEGGQALAIRLSGDQAALWGCGFFGAQDTLFDDVGRHYFKDCFIEGSVDFIFGNARSLFENCILNSIAEAKPTIKGNVNAAITAQARESEANHTGFSFVNCTIKGTSEILLGRAYRPYSRVIFAHTYISNILASQGWSDFGKPSNQRTVFYGEYMCTGEGAKRTERV... | 125 |
Q54LP7 | 2.3.2.23 | ACT_SITE 89; /note="Glycyl thioester intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00388" | MSTQVCVTRLKKELLALSKNEDIKDIFIAKPSISNILEWHYVIYGPPDTPYHGGYYHGQIIFPVEYPYKPPSILMTTPSGRFVCNSRICTSMSDFHPDTWSPFWSNCTIILGLISFMTEDENGFGSIVKSKETRKQLASQSMAFNLKNPVFVKLFPELISDYKKKGTFYSSSSTPSSTPPPSSTPSSSSSSSNISKRNVPIPTTKTTPQDTNKKKEQKNNNIPYIILFIALIIILLYLFLK | 64 |
Q9VH08 | 2.3.1.286 | ACT_SITE 133; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00236" | MSCNYADGLSAYDNKGILGAPESFDSDEVVAEKCQELAELIKKSGHVVLHTGAGISTSAGIPDFRGPKGVWTLEEKGEKPDFNVSFDEARPTKTHMAIIALIESGYVQYVISQNIDGLHLKSGLDRKYLSELHGNIYIEQCKKCRRQFVSPSAVETVGQKSLQRACKSSMDSKGRSCRSGILYDNVLDWEHDLPENDLEMGVMHSTVADLNIALGTTLQIVPSGDLPLKNLKCGGKFVICNLQPTKHDKKANLIISSYVDVVLSKVCKLLGVEIPEYSEASDPTKQSKPMEWTIPTSNVNTFHRQYKKYVYFIYYLL | 58 |
Q8A9B6 | 5.6.2.2 | ACT_SITE 121; /note="O-(5'-phospho-DNA)-tyrosine intermediate"; /evidence="ECO:0000256|HAMAP-Rule:MF_01897" | MLEQDRIIKINIEEEMKSSYIDYSMSVIVSRALPDVRDGFKPVHRRILYGMMELGNTSDKPYKKSARIVGEVLGKYHPHGDSSVYYAMVRMAQEWAMRYPLVDGQGNFGSVDGDSPAAMRYTEARLNKLGEAMMDDLYKETVDFEPNFDNTLTEPKVMPTRIPNLLVNGASGIAVGMATNMPPHNLSEVIDACEAYIDNQEITVEELMTYVKAPDFPTGGYIYGISGVREGYLTGRGRVVMRAKAEIETGQTHDKIVVTEIPYNVNKAELIKYIADLVNDKRIEGISNANDESDRDGMRIVIDVKRDANASVVLNKLYKM... | 222 |
Q9K1P9 | 2.6.1.16 | ACT_SITE 2; /note="Nucleophile; for GATase activity"; /evidence="ECO:0000255|HAMAP-Rule:MF_00164"; ACT_SITE 607; /note="For Fru-6P isomerization activity"; /evidence="ECO:0000255|HAMAP-Rule:MF_00164" | MCGIVGAIRAHHNVVDFLTDGLKRLEYRGYDSSGIAVNTDGKIKRVRRVGRVQLMEDAAREKGISGGIGIGHTRWATHGGVTEPNAHPHISGGMIAVVHNGIIENFESERKRLEGLGYRFESQTDTEVIAHSINHEYAQNGGRLFEAVQEAVKRFHGAYAIAVIAQDKPDELVVARMGCPLLVALGDDETFIASDVSAVIAFTRRVAYLEDGDIALLASDGIKRLTDKNGLPAERKVKVSELSLASLELGLYSHFMQKEIHEQPRAIADTAEVFLDGGFIPENFGKDAKSVFESIRSVKILACGTSYYAALTAKYWLESI... | 81 |
A7SA51 | 3.1.3.3 | ACT_SITE 19; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR604469-1"; ACT_SITE 21; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR604469-1" | MTESETRVIWKSADAVCFDVDSTVVTGEAIDELASFCGRGEEVAEWTRRAMRGGVSFREALENRLKIIQPSSKQLEEFIKSNKLELTPFVRNVIDCLLSHGTQVYLVSGGFQSILEPIAKDLGIPKTNVFANKILFNSNGDYCGFDKEAFTSSSGGKARVVQLLKDKYQYKRLVVIGDGVTDMEACPPADAFIGFGGNVVREQVKANAPWFVTDFKVLLDAL | 147 |
P38139 | 3.1.1.3 | ACT_SITE 177; /note="Charge relay system"; /evidence="ECO:0000250|UniProtKB:O75608" | MNMAERAEATKSWSCEPLSGKTLEEIVQNAENAADLVAYIRKPEVDLDFRLKFIAEHEEFFNVQLSDRNSRIRTCHNLSDKGIRGDTVFVFVPGLAGNLEQFEPLLELVDSDQKAFLTLDLPGFGHSSEWSDYPMLKVVELIFVLVCDVLRKWSTAVPNNDNVNPFNGHKIVLVGHSMGCFLACHLYEQHMADTKAVQTLVLLTPPKAHIEQLSKDKHIIQWALYGVFKLPWLFDVYRNKFDQVKGLQSSGIKQYFYQQGDDVKLKYRKFWQFKNNISNKSRTIIGYLLGWETVDWVKFNGVLTQTDMKQKIIIFGAEKD... | 128 |
M0R5X1 | 3.1.3.16 | ACT_SITE 106; /note="4-aspartylphosphate intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR640078-1"; ACT_SITE 108; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR640078-1" | MEHGSIITQARREDALVLTKQGLVSKSSPKKPRGRSIFKALLCCFHTQHVSQSSSSTELTHKEEANTIAKSDLLQCLQYQFYQIPGTCLLPEVTEQDQGRICVVIDLDETLVHSSFKPINNADFIVPVEIEGTTHQVYVLKRPYVDEFLRRMGELFECVLFTASLAKYADPVTDLLDRCGVFRARLFRESCVFHQGCYVKDLSRLGRDLRKTVILDNSPASYIFHPENAVSAPDQASNWGWLQAGTVGFIRGVHYPCVAQQPPVALERKGKVR | 144 |
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