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{"1020": 0.26446542143821716, "1023": 0.04674193635582924, "1044": 0.3850763738155365, "2001": 0.020300358533859253, "2007": 0.16359257698059082, "2039": 0.1930064558982849, "2044": 0.5063233375549316, "2053": 0.5301685929298401, "2076": 0.27044451236724854, "2078": 0.13925230503082275, "2089": 0.08603433519601822, "21... | 19052713 | OBJECTIVE To quantify effect on mortality of administering human albumin or plasma protein fraction during management of critically ill patients. DESIGN Systematic review of randomised controlled trials comparing administration of albumin or plasma protein fraction with no administration or with administration of cryst... | Human albumin administration in critically ill patients: systematic review of randomised controlled trials. |
{"2003": 0.12556517124176025, "2024": 0.013579257763922215, "2045": 0.11168810725212097, "2048": 0.18816383183002472, "2054": 0.13414156436920166, "2057": 0.0354953333735466, "2058": 0.6064908504486084, "2073": 0.004870930220931768, "2079": 0.021256839856505394, "2109": 0.23556606471538544, "2116": 0.6583697199821472, ... | 19058822 | Genetic maps, which document the way in which recombination rates vary over a genome, are an essential tool for many genetic analyses. We present a high-resolution genetic map of the human genome, based on statistical analyses of genetic variation data, and identify more than 25,000 recombination hotspots, together wit... | A fine-scale map of recombination rates and hotspots across the human genome. |
{"1011": 0.06703783571720123, "1039": 0.19622190296649933, "1041": 0.026976587250828743, "1050": 0.1905880719423294, "1998": 0.25845035910606384, "2000": 0.25845035910606384, "2003": 0.04674193635582924, "2005": 0.11691460013389587, "2007": 0.05786345899105072, "2015": 0.16442140936851501, "2028": 0.31132611632347107, ... | 19071857 | Pre-operative psychological assessment is recommended by international guidelines for bariatric surgery candidates. Thereby, service teams caring for bariatric patients should include at least one mental health provider (e.g., a psychologist or psychiatrist). The objective of this study was to evaluate the psychology a... | Mental Health Support Provided Throughout the Bariatric Surgery Clinical Pathway in French Specialized Care Centers for Obesity |
{"1009": 1.149384617805481, "1039": 0.40806588530540466, "1997": 0.18329764902591705, "1998": 0.12986256182193756, "1999": 0.05694137513637543, "2005": 0.11604541540145874, "2029": 0.14179791510105133, "2030": 0.5220900774002075, "2048": 0.1710275560617447, "2054": 0.21922965347766876, "2058": 0.6202403903007507, "2061... | 19079491 | To live or to die? This crucial question eloquently reflects the dual role of Ca2+ in living organisms – survival factor or ruthless killer. It has long been known that Ca2+ signals govern a host of vital cell functions and so are necessary for cell survival. However, more recently it has become clear that cellular Ca2... | Calcium: Regulation of cell death: the calcium–apoptosis link |
{"1011": 0.11256109178066254, "1017": 0.13925230503082275, "1041": 0.014542185701429844, "1056": 0.562402069568634, "1060": 0.9037119746208191, "1518": 0.20739519596099854, "1999": 0.058784693479537964, "2003": 0.10906458646059036, "2004": 0.16607704758644104, "2005": 0.034552380442619324, "2008": 0.05970508232712746, ... | 19099739 | The pathogenicity of many bacteria depends on the injection of effector proteins via type III secretion into eukaryotic cells in order to manipulate cellular processes. TAL (transcription activator-like) effectors from plant pathogenic Xanthomonas are important virulence factors that act as transcriptional activators i... | Breaking the code of DNA binding specificity of TAL-type III effectors. |
{"1011": 0.6223390698432922, "1043": 0.7454653382301331, "1045": 0.23556606471538544, "1157": 1.1864371299743652, "2003": 0.30989447236061096, "2005": 0.12384103983640671, "2010": 0.6139179468154907, "2029": 0.3870677351951599, "2039": 0.10993985831737518, "2065": 1.4227317571640015, "2071": 0.11168810725212097, "2078"... | 19130782 | Interferon-gamma (IFN-γ) is a pleiotropic molecule with associated antiproliferative, pro-apoptotic and antitumor mechanisms. This effector cytokine, often considered as a major effector of immunity, has been used in the treatment of several diseases, despite its adverse effects. Although broad evidence implicating IFN... | Interferon-Gamma at the Crossroads of Tumor Immune Surveillance or Evasion |
{"1050": 0.38041436672210693, "1052": 0.6254787445068359, "1053": 0.34715715050697327, "2003": 0.48430517315864563, "2011": 0.23710809648036957, "2019": 0.3750596046447754, "2024": 0.09406650811433792, "2064": 0.013579257763922215, "2102": 1.059443712234497, "2109": 0.07431721687316895, "2152": 0.0174254160374403, "220... | 19132741 | Paraquat, a quarternary nitrogen herbicide, is a highly toxic compound for humans and animals and many cases of acute poisoning and death have been reported over the past few decades. The mechanisms of paraquat toxicity involve: the generation of the superoxide anion, which can lead to the formation of more toxic react... | Role of antioxidants in paraquat toxicity. |
{"1037": 0.05046287178993225, "1996": 0.043007105588912964, "1997": 0.0913962796330452, "1998": 0.0354953333735466, "2004": 0.29255300760269165, "2005": 0.043007105588912964, "2010": 0.7764897346496582, "2011": 0.3519764244556427, "2015": 0.21687394380569458, "2029": 0.13670019805431366, "2064": 0.4837033152580261, "20... | 19138874 | The biogenesis of the many functional compartments contained in the mammalian cell nucleus is poorly understood. More specifically, little is known regarding the initial nucleation step required for nuclear body formation. Here we show that RNA can function as a structural element and a nucleator of nuclear bodies. We ... | Nucleation of nuclear bodies by RNA |
{"1003": 0.21530038118362427, "1014": 0.2501201331615448, "1021": 0.3353555500507355, "1022": 0.35060185194015503, "1023": 0.21135559678077698, "1052": 0.3241194784641266, "1058": 0.10818854719400406, "2004": 0.7500885725021362, "2005": 0.2034190446138382, "2007": 0.2969166338443756, "2011": 0.38174858689308167, "2012"... | 19140422 | CONTEXT Human papillomavirus (HPV) DNA testing of women having Papanicolaou (Pap) smears showing atypical squamous cells of undetermined significance (ASCUS) has clinical usefulness. Whether HPV DNA testing alone is useful in primary screening remains to be determined. OBJECTIVE To determine the accuracy of HPV DNA tes... | Evaluation of human papillomavirus testing in primary screening for cervical abnormalities: comparison of sensitivity, specificity, and frequency of referral. |
{"1057": 1.15000319480896, "2003": 0.36426326632499695, "2008": 0.22001366317272186, "2011": 0.11691460013389587, "2015": 0.817850649356842, "2024": 0.19220098853111267, "2029": 0.32270604372024536, "2033": 0.29619070887565613, "2036": 0.5220900774002075, "2054": 0.10203468054533005, "2060": 0.0752234235405922, "2079":... | 19149247 | Ubiquitylation is a reversible protein modification that is implicated in many cellular functions. Recently, much progress has been made in the characterization of a superfamily of isopeptidases that remove ubiquitin: the deubiquitinases (DUBs; also known as deubiquitylating or deubiquitinating enzymes). Far from being... | Breaking the chains: structure and function of the deubiquitinases |
{"1011": 0.2034190446138382, "1037": 0.8666408061981201, "1047": 0.1994270235300064, "1054": 1.4542449712753296, "1997": 0.09317722171545029, "2003": 0.3339579105377197, "2005": 0.27564704418182373, "2008": 0.1510767638683319, "2011": 0.33953672647476196, "2024": 0.15526613593101501, "2029": 0.23015019297599792, "2036"... | 19165076 | Replication protein A [RPA; also known as replication factor A (RFA) and human single-stranded DNA-binding protein] is a single-stranded DNA-binding protein that is required for multiple processes in eukaryotic DNA metabolism, including DNA replication, DNA repair, and recombination. RPA homologues have been identified... | Replication protein A: a heterotrimeric, single-stranded DNA-binding protein required for eukaryotic DNA metabolism. |
{"1011": 0.020300358533859253, "1014": 0.24859806895256042, "1016": 0.2026219218969345, "1017": 0.5255602598190308, "1019": 0.4770587682723999, "1041": 0.7124901413917542, "1052": 0.5984715819358826, "1053": 0.2689530849456787, "2001": 0.04953393340110779, "2044": 0.12986256182193756, "2048": 0.09584271162748337, "2067... | 19182166 | BACKGROUND The aim of the study was to report the 2-year outcome after a displaced 3-part fracture of the proximal humerus in elderly patients randomized to treatment with a locking plate or nonoperative treatment. PATIENTS AND METHODS We included 60 patients, mean age 74 years (range, 56-92), 81% being women. The main... | Internal fixation versus nonoperative treatment of displaced 3-part proximal humeral fractures in elderly patients: a randomized controlled trial. |
{"1042": 0.7009293437004089, "1043": 0.23633737862110138, "1044": 0.38308101892471313, "2000": 0.06795065850019455, "2005": 0.16359257698059082, "2029": 0.04674193635582924, "2047": 0.11691460013389587, "2064": 0.08513788133859634, "2071": 0.23556606471538544, "2076": 0.12384103983640671, "2079": 0.0174254160374403, "2... | 19185192 | The shift in substrate preference away from fatty acid oxidation (FAO) towards increased glucose utilization in heart failure has long been interpreted as an oxygen-sparing mechanism. Inhibition of FAO has therefore evolved as an accepted approach to treat heart failure. However, recent data indicate that increased rel... | Good and bad consequences of altered fatty acid metabolism in heart failure: evidence from mouse models. |
{"1009": 0.5629584193229675, "1011": 0.1734936386346817, "1040": 0.5080875158309937, "1060": 0.37974658608436584, "1999": 0.00875066313892603, "2008": 0.08513788133859634, "2011": 0.004870930220931768, "2013": 0.5882205963134766, "2015": 0.16524957120418549, "2024": 0.05046287178993225, "2025": 0.1677299439907074, "202... | 19204979 | Cells derived from blood vessels of human skeletal muscle can regenerate skeletal muscle, similarly to embryonic mesoangioblasts. However, adult cells do not express endothelial markers, but instead express markers of pericytes, such as NG2 proteoglycan and alkaline phosphatase (ALP), and can be prospectively isolated ... | Pericytes of human skeletal muscle are myogenic precursors distinct from satellite cells |
{"1014": 0.2607102394104004, "1019": 0.2622140049934387, "1048": 0.06703783571720123, "1051": 0.2954642176628113, "2004": 0.06246116757392883, "2005": 0.49864232540130615, "2007": 0.255429208278656, "2043": 0.014542185701429844, "2044": 0.09050461649894714, "2048": 0.029824240133166313, "2051": 0.23015019297599792, "20... | 19205326 | BACKGROUND Antiresorptive agents are widely used to treat osteoporosis. We report the results of a multinational randomized, double-blind study, in which postmenopausal women with osteoporosis were treated with alendronate for up to 10 years. METHODS The initial three-year phase of the study compared three daily doses ... | Ten years' experience with alendronate for osteoporosis in postmenopausal women. |
{"1009": 0.3170322775840759, "1011": 0.16607704758644104, "1015": 0.4794800877571106, "1016": 0.10203468054533005, "1043": 0.1718502640724182, "1052": 0.22704219818115234, "1057": 0.022212404757738113, "1156": 0.1602703034877777, "2004": 0.04487626627087593, "2008": 0.007782140281051397, "2011": 0.38308101892471313, "2... | 19205437 | Uncoupling protein 1 (UCP1) plays a central role in nonshivering thermogenesis in brown fat; however, its role in beige fat remains unclear. Here we report a robust UCP1-independent thermogenic mechanism in beige fat that involves enhanced ATP-dependent Ca2+ cycling by sarco/endoplasmic reticulum Ca2+-ATPase 2b (SERCA2... | UCP1-independent signaling involving SERCA2b-mediated calcium cycling regulates beige fat thermogenesis and systemic glucose homeostasis |
{"1011": 0.053244512528181076, "1037": 0.07159364968538284, "1040": 0.3588210940361023, "2005": 0.030771657824516296, "2011": 0.21214580535888672, "2015": 0.08961215615272522, "2029": 0.13670019805431366, "2061": 0.6212902665138245, "2078": 1.222740888595581, "2109": 0.015504186972975731, "2179": 0.12038381397724152, "... | 19255949 | Mutations in the PARN gene (encoding poly(A)-specific ribonuclease) cause telomere diseases including familial idiopathic pulmonary fibrosis (IPF) and dyskeratosis congenita, but how PARN deficiency impairs telomere maintenance is unclear. Here, using somatic cells and induced pluripotent stem cells (iPSCs) from patien... | Poly(A)-specific ribonuclease (PARN) mediates 3′-end maturation of the telomerase RNA component |
{"1014": 0.2990913391113281, "1042": 1.15000319480896, "1052": 0.13071982562541962, "1998": 0.2160874605178833, "2005": 0.34300774335861206, "2007": 0.05139094591140747, "2038": 0.0038986403960734606, "2042": 0.10203468054533005, "2050": 0.17020416259765625, "2064": 0.06154331564903259, "2069": 0.011650617234408855, "2... | 19278208 | Background/Objectives:Folic acid supplementation has been suggested to reduce the risk of preeclampsia. However, results from few epidemiologic studies have been inconclusive. We investigated the hypothesis that folic acid supplementation and dietary folate intake before conception and during pregnancy reduce the risk ... | Folic acid supplementation and dietary folate intake, and risk of preeclampsia |
{"1011": 0.4425300657749176, "1055": 0.16524957120418549, "2003": 0.12986256182193756, "2008": 0.0606246218085289, "2015": 1.3001704216003418, "2029": 0.2089812457561493, "2063": 0.02887592278420925, "2075": 0.06246116757392883, "2099": 0.319873183965683, "2109": 0.4855078160762787, "2135": 0.037378571927547455, "2224"... | 19293654 | We present Model-based Analysis of ChIP-Seq data, MACS, which analyzes data generated by short read sequencers such as Solexa's Genome Analyzer. MACS empirically models the shift size of ChIP-Seq tags, and uses it to improve the spatial resolution of predicted binding sites. MACS also uses a dynamic Poisson distributio... | Model-based Analysis of ChIP-Seq (MACS) |
{"1003": 0.24631060659885406, "1017": 0.09672962874174118, "1018": 0.020300358533859253, "1020": 0.08782484382390976, "1022": 0.06977381557226181, "1042": 0.2689530849456787, "1044": 0.23633737862110138, "1053": 0.12986256182193756, "2004": 0.07068414986133575, "2007": 0.39696553349494934, "2015": 0.029824240133166313,... | 19307912 | Using the Princeton School District Family Study cohort, our specific aim was to estimate the prevalence of suspected familial ponderosity and leanness, to provide empirical risk estimates for the proportion of probands' first-degree relatives who were similarly affected, and to estimate the contributions of diseases, ... | Familial obesity and leanness. |
{"1011": 0.08244366943836212, "1052": 0.812664806842804, "1609": 0.3346569836139679, "1998": 0.10731173306703568, "2000": 0.25995752215385437, "2004": 0.5838727951049805, "2005": 0.0752234235405922, "2007": 0.3381449282169342, "2015": 0.5844172835350037, "2029": 0.23402166366577148, "2058": 0.08871890604496002, "2072":... | 19308127 | BACKGROUND P2Y12 inhibitor switching has appeared in clinical practice as a consequence of prasugrel and ticagrelor availability, apart from clopidogrel, for use in patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI). METHODS In the context of the GReek AntiPlatelet REgistry ... | In-hospital switching of oral P2Y12 inhibitor treatment in patients with acute coronary syndrome undergoing percutaneous coronary intervention: prevalence, predictors and short-term outcome. |
{"1011": 0.24325250089168549, "1016": 0.5930894017219543, "1019": 0.006812678650021553, "1047": 0.5773153901100159, "1061": 0.1510767638683319, "1155": 0.12986256182193756, "2003": 0.2918238639831543, "2005": 0.41001203656196594, "2008": 0.1510767638683319, "2029": 0.2689530849456787, "2048": 0.2018241584300995, "2079"... | 19313533 | The metabolic stress-sensing enzyme AMP-activated protein kinase (AMPK) is responsible for regulating metabolism in response to energy supply and demand. Drugs that activate AMPK may be useful in the treatment of metabolic diseases including type 2 diabetes. We have determined the crystal structure of AMPK in complex w... | Structural basis of allosteric and synergistic activation of AMPK by furan-2-phosphonic derivative C2 binding. |
{"1014": 0.2786078155040741, "1043": 0.3443928062915802, "1050": 0.15359249711036682, "1054": 0.6332852244377136, "1164": 0.08603433519601822, "1997": 0.07341018319129944, "2009": 0.06337817758321762, "2012": 0.39893341064453125, "2043": 0.26296505331993103, "2048": 0.25845035910606384, "2063": 0.011650617234408855, "2... | 19315511 | OBJECTIVE To test the validity of age at menarche self-reported in adulthood and examine whether socioeconomic position, education, experience of gynaecological events and psychological symptoms influence the accuracy of recall. DESIGN Prospective birth cohort study. SETTING England, Scotland and Wales. PARTICIPANTS 10... | Validity of age at menarche self-reported in adulthood. |
{"1011": 0.02412080205976963, "1015": 0.1212492436170578, "1017": 0.23402166366577148, "1038": 0.2837681770324707, "1040": 0.4113073945045471, "1044": 0.6202403903007507, "1045": 0.3248254358768463, "1048": 0.1970241367816925, "1054": 0.3283478021621704, "1056": 0.14939609169960022, "1999": 0.21687394380569458, "2001":... | 19327364 | Sera from 526 Old-World monkeys and apes, representing 50 species and 20 genera and living in US zoos and vivaria, were screened for antibodies to HTLV-I, HTLV-III/LAV, and simian-AIDS retrovirus, type I (SRV-I). Sera were screened initially by ELISA, and ELISA-positive sera, as well as ELISA-negative sera from cage co... | Seroepidemiologic survey of captive Old-World primates for antibodies to human and simian retroviruses, and isolation of a lentivirus from sooty mangabeys (Cercocebus atys). |
{"1020": 0.12038381397724152, "1022": 0.13414156436920166, "1040": 0.22859740257263184, "1525": 0.012615402229130268, "1999": 0.1751343309879303, "2003": 0.175953671336174, "2004": 0.026025565341114998, "2007": 0.22704219818115234, "2011": 0.08871890604496002, "2012": 0.8022117614746094, "2026": 0.46363574266433716, "2... | 19332616 | Coronary atherosclerosis is by far the most frequent cause of ischemic heart disease, and plaque disruption with superimposed thrombosis is the main cause of the acute coronary syndromes of unstable angina, myocardial infarction, and sudden death.1 2 3 4 5 Therefore, for event-free survival, the vital question is not w... | Coronary plaque disruption. |
{"1014": 0.1873544454574585, "1015": 0.0354953333735466, "1018": 0.07884006202220917, "1020": 0.2659635543823242, "1038": 0.7845434546470642, "1052": 0.8450632095336914, "1999": 0.07431721687316895, "2007": 0.14264501631259918, "2029": 0.2478361576795578, "2034": 0.1946154683828354, "2043": 0.10555581003427505, "2050":... | 19343151 | The cell-cycle regulating gene, p16INK4A, encoding an inhibitor of cyclin-dependent kinases 4 and 6, is considered to play an important role in cellular aging and in premature senescence. Although there is an age-dependent increase of p16INK4A expression in human fibroblast senescence in vitro, no data are available re... | p16INK4A is a robust in vivo biomarker of cellular aging in human skin. |
{"1011": 0.66441810131073, "1015": 0.3963087201118469, "1049": 0.11517547070980072, "1052": 0.28963330388069153, "1054": 0.6461620330810547, "2003": 0.4425300657749176, "2007": 0.08064348995685577, "2008": 0.1401015669107437, "2011": 0.06612417846918106, "2024": 0.28597161173820496, "2028": 0.12038381397724152, "2029":... | 19356271 | Prim-pol is a recently identified DNA primase-polymerase belonging to the archaeao-eukaryotic primase (AEP) superfamily. Here, we characterize a previously unrecognized prim-pol in human cells, which we designate hPrimpol1 (human primase-polymerase 1). hPrimpol1 possesses primase and DNA polymerase activities in vitro,... | hPrimpol1/CCDC111 is a human DNA primase-polymerase required for the maintenance of genome integrity. |
{"1011": 0.34300774335861206, "1043": 0.2969166338443756, "1049": 0.037378571927547455, "1051": 0.3560888469219208, "1052": 0.5751199722290039, "1060": 0.5551415085792542, "2004": 0.21135559678077698, "2005": 0.1229778528213501, "2006": 0.6684301495552063, "2010": 0.319873183965683, "2011": 0.23247487843036652, "2026":... | 19358586 | The myc oncogene is overexpressed in almost half of all breast and ovarian cancers, but attempts at therapeutic interventions against myc have proven to be challenging. Myc regulates multiple biological processes, including the cell cycle, and as such is associated with cell proliferation and tumor progression. We iden... | Functional proteomics identifies miRNAs to target a p27/Myc/phospho-Rb signature in breast and ovarian cancer |
{"1011": 0.5092619061470032, "1014": 0.5646255612373352, "1026": 0.30558720231056213, "1037": 0.5063233375549316, "1044": 0.3777405619621277, "1052": 0.48970574140548706, "1053": 0.8315495252609253, "1998": 0.13499516248703003, "1999": 0.13157635927200317, "2002": 1.105748176574707, "2004": 0.25239890813827515, "2005":... | 19368793 | BACKGROUND Hepatocellular carcinoma (HCC) is regarded as one of the most common malignancies and among the leading causes of cancer death among the whole world. The most urgent needs are to find sensitive markers for early diagnosis for HCC. MicroRNAs (miRNAs) are reported as a group of small non-coding RNAs that can f... | The potential role of miRNAs 21 and 199-a in early diagnosis of hepatocellular carcinoma. |
{"1011": 0.22001366317272186, "1041": 0.00875066313892603, "1055": 0.5506471395492554, "2003": 0.16110190749168396, "2005": 0.1064341589808464, "2008": 0.10555581003427505, "2010": 0.6128603219985962, "2011": 0.22937409579753876, "2015": 1.2082605361938477, "2024": 0.24554696679115295, "2029": 0.21530038118362427, "206... | 19384430 | Super-enhancers (SEs) are large clusters of transcriptional enhancers that are co-occupied by multiple lineage-specific transcription factors driving expression of genes that define cell identity. In embryonic stem cells (ESCs), SEs are highly enriched for the core pluripotency factors Oct4, Sox2, and Nanog. In this st... | Tex10 Coordinates Epigenetic Control of Super-Enhancer Activity in Pluripotency and Reprogramming. |
{"1011": 0.0058422754518687725, "1014": 0.04113444685935974, "1043": 0.7755908370018005, "1054": 0.23556606471538544, "2001": 0.052318159490823746, "2005": 0.08244366943836212, "2006": 0.306306391954422, "2042": 0.09672962874174118, "2043": 0.11865071207284927, "2044": 0.7791815400123596, "2045": 0.009718249551951885, ... | 19408393 | AIMS There is controversy in published studies regarding the role of repeat whole brain radiation (WBRT) for previously irradiated brain metastases. The aim of our retrospective study was to document the practice at Princess Margaret Hospital with respect to the re-irradiation of patients with progressive or recurrent ... | Value of whole brain re-irradiation for brain metastases--single centre experience. |
{"1038": 0.02887592278420925, "1052": 0.05046287178993225, "1999": 0.0009760859538801014, "2003": 0.0174254160374403, "2005": 0.5116065740585327, "2006": 0.4374985992908478, "2038": 0.08782484382390976, "2064": 0.05139094591140747, "2079": 0.13670019805431366, "2080": 0.34370049834251404, "2109": 0.755608320236206, "22... | 19419439 | The introduction of bisphosphonates in oncology has dramatically changed the management of patients with metastatic bone disease. In this manuscript, we thoroughly scrutinize the available body of clinical trials supporting the use of bisphosphonates in this setting and review new and ongoing research. Additionally, we... | Bisphosphonates in oncology: rising stars or fallen heroes. |
{"1011": 0.48430517315864563, "1015": 0.5914691090583801, "1016": 0.24248650670051575, "1017": 0.0317181795835495, "1019": 0.02316705882549286, "1020": 0.20818853378295898, "1044": 0.06977381557226181, "1999": 0.11081436276435852, "2007": 0.1930064558982849, "2012": 0.2531573474407196, "2028": 0.27044451236724854, "202... | 19427410 | Inflammation occurs in adipose tissue in obesity. We have examined whether IL-33, a recently identified IL-1 gene family member, and its associated receptors are expressed in human adipocytes. IL-33, IL-1RL1 and IL-1RAP gene expression was observed in human visceral white fat, in preadipocytes and in adipocytes (SGBS c... | IL-33, a recently identified interleukin-1 gene family member, is expressed in human adipocytes. |
{"1048": 0.7863243818283081, "2000": 0.10467668622732162, "2031": 0.053244512528181076, "2038": 0.2493593990802765, "2047": 0.22704219818115234, "2064": 0.2689530849456787, "2071": 0.022212404757738113, "2079": 0.04767346754670143, "2109": 0.5729197263717651, "2129": 0.16690383851528168, "2156": 0.11256109178066254, "2... | 19450341 | Imaging techniques have greatly improved our understanding of lymphocyte activation. Technical advances in spatial and temporal resolution and new labelling tools have enabled researchers to directly observe the activation process. Consequently, research using imaging approaches to study lymphocyte activation has expan... | Imaging techniques for assaying lymphocyte activation in action |
{"1054": 0.6244332790374756, "1998": 0.1384023278951645, "2003": 0.09228714555501938, "2011": 0.21214580535888672, "2037": 0.13755162060260773, "2043": 0.02316705882549286, "2062": 0.04953393340110779, "2064": 0.28597161173820496, "2071": 0.08244366943836212, "2076": 0.1930064558982849, "2079": 0.2954642176628113, "208... | 19460822 | When the food intake of organisms such as yeast and rodents is reduced (dietary restriction), they live longer than organisms fed a normal diet. A similar effect is seen when the activity of nutrient-sensing pathways is reduced by mutations or chemical inhibitors. In rodents, both dietary restriction and decreased nutr... | Extending healthy life span--from yeast to humans. |
{"1015": 0.21214580535888672, "1017": 0.15275461971759796, "1052": 0.2105647772550583, "1997": 0.01934296265244484, "2001": 0.045809537172317505, "2012": 0.22626367211341858, "2028": 0.22548456490039825, "2044": 0.24554696679115295, "2047": 0.030771657824516296, "2051": 0.21687394380569458, "2077": 0.4158279001712799, ... | 19464037 | OBJECTIVE To describe outcomes and identify variables associated with hospital and 1-year survival for patients admitted to an intensive care unit (ICU) with an acute exacerbation of chronic obstructive pulmonary disease (COPD). DESIGN Prospective, multicenter, inception cohort study. SETTING Forty-two ICUs at 40 US ho... | Hospital and 1-year survival of patients admitted to intensive care units with acute exacerbation of chronic obstructive pulmonary disease. |
{"1011": 0.21372433006763458, "1017": 0.6155022978782654, "1045": 0.2493593990802765, "1156": 0.6872705817222595, "1999": 0.09761575609445572, "2003": 0.07884006202220917, "2004": 0.06246116757392883, "2005": 0.2231435477733612, "2006": 0.4158279001712799, "2011": 0.00875066313892603, "2012": 0.42353010177612305, "2015... | 19482914 | Integrin-mediated platelet adhesion and aggregation are essential for sealing injured blood vessels and preventing blood loss, and excessive platelet aggregation can initiate arterial thrombosis, causing heart attacks and stroke. To ensure that platelets aggregate only at injury sites, integrins on circulating platelet... | Kindlin-3 is essential for integrin activation and platelet aggregation |
{"1011": 0.4437839686870575, "1013": 0.0317181795835495, "1015": 0.08692999184131622, "1017": 0.3485364317893982, "1018": 0.6517757177352905, "1039": 0.26296505331993103, "1041": 0.42096930742263794, "1042": 0.1229778528213501, "1043": 0.016465263441205025, "1044": 0.8091925978660583, "1050": 0.6588751673698425, "1996"... | 19485243 | The transcription factors HNF3 (FoxA) and GATA-4 are the earliest known to bind the albumin gene enhancer in liver precursor cells in embryos. To understand how they access sites in silent chromatin, we assembled nucleosome arrays containing albumin enhancer sequences and compacted them with linker histone. HNF3 and GA... | Opening of compacted chromatin by early developmental transcription factors HNF3 (FoxA) and GATA-4. |
{"1011": 0.24325250089168549, "1039": 0.6149744987487793, "1041": 0.6139179468154907, "1042": 0.8091925978660583, "1050": 0.6739205718040466, "1060": 0.7800771594047546, "1996": 0.009718249551951885, "1998": 0.013579257763922215, "1999": 0.0354953333735466, "2003": 0.07884006202220917, "2006": 0.08871890604496002, "201... | 19485649 | Transmembrane cadherins are calcium-dependent intercellular adhesion molecules. Recently, they have also been shown to be sites of actin assembly during adhesive contact formation. However, the roles of actin assembly on transmembrane cadherins during development are not fully understood. We show here, using the develo... | N- and E-cadherins in Xenopus are specifically required in the neural and non-neural ectoderm, respectively, for F-actin assembly and morphogenetic movements. |
{"1039": 0.04207121208310127, "1040": 0.40741631388664246, "1043": 0.5811457633972168, "1047": 0.6301699280738831, "1048": 0.25995752215385437, "1999": 0.3012613356113434, "2001": 0.030771657824516296, "2029": 0.10467668622732162, "2034": 0.5347557663917542, "2048": 0.5756692886352539, "2050": 0.020300358533859253, "20... | 19487477 | We report an inborn error of the tricarboxylic acid cycle, fumarase deficiency, in two siblings born to first cousin parents. They presented with progressive encephalopathy, dystonia, leucopenia, and neutropenia. Elevation of lactate in the cerebrospinal fluid and high fumarate excretion in the urine led us to investig... | Mutation of the fumarase gene in two siblings with progressive encephalopathy and fumarase deficiency. |
{"1038": 0.7239188551902771, "1058": 0.52266925573349, "1996": 0.3916989266872406, "1997": 0.07793712615966797, "1999": 0.12728634476661682, "2004": 0.28670501708984375, "2013": 0.06429435312747955, "2029": 0.2247048318386078, "2042": 0.026976587250828743, "2043": 0.020300358533859253, "2051": 0.11343330889940262, "205... | 19489351 | Somatic stem cells have been identified in multiple adult tissues. Whether self-renewal occurs symmetrically or asymmetrically is key to understanding long-term stem cell maintenance and generation of progeny for cell replacement. In the adult mouse brain, neural stem cells (NSCs) (B1 cells) are retained in the walls o... | Adult Neurogenesis Is Sustained by Symmetric Self-Renewal and Differentiation. |
{"1020": 0.02412080205976963, "1052": 0.3027053773403168, "1055": 0.5045560002326965, "1056": 0.7417513132095337, "2005": 0.1011524572968483, "2007": 0.23556606471538544, "2029": 0.1930064558982849, "2064": 0.23710809648036957, "2078": 0.10026945173740387, "2084": 0.14686977863311768, "2102": 0.5718178153038025, "2109"... | 19497526 | Thiopurine therapy, commonly used in autoimmune conditions, can be complicated by life-threatening leukopenia. This leukopenia is associated with genetic variation in TPMT (encoding thiopurine S-methyltransferase). Despite a lower frequency of TPMT mutations in Asians, the incidence of thiopurine-induced leukopenia is ... | A common missense variant in NUDT15 confers susceptibility to thiopurine-induced leukopenia |
{"1009": 0.46117570996284485, "1011": 0.17020416259765625, "1039": 0.32341301441192627, "1043": 0.6075552701950073, "1996": 0.04394211992621422, "1999": 0.11691460013389587, "2005": 0.39696553349494934, "2007": 0.08513788133859634, "2011": 0.06337817758321762, "2026": 0.674915611743927, "2029": 0.21214580535888672, "20... | 19510470 | Cancer stem cells have been proposed to be important for initiation, maintenance and recurrence of various malignancies, including acute myeloid leukemia (AML). We have previously reported that CD34+CD38− human primary AML stem cells residing in the endosteal region of the bone marrow are relatively chemotherapy resist... | Induction of cell cycle entry eliminates human leukemia stem cells in a mouse model of AML |
{"1038": 0.5244048833847046, "1039": 0.043007105588912964, "1044": 0.2741633653640747, "1056": 0.6754127144813538, "2002": 0.2516399025917053, "2029": 0.12470348179340363, "2034": 0.08603433519601822, "2043": 0.0752234235405922, "2044": 0.8796916007995605, "2064": 0.06337817758321762, "2065": 0.0770333781838417, "2067"... | 19511011 | Hematopoietic stem cell transplantation is associated with a severe immune deficiency. As a result, the patient is at high risk of infections. Innate immunity, including epithelial barriers, monocytes, granulocytes, and NK cells recovers within weeks after transplantation. By contrast, adaptive immunity recovers much s... | Reconstitution of the immune system after hematopoietic stem cell transplantation in humans |
{"1041": 0.5827828645706177, "1043": 0.3883931338787079, "1054": 0.6353566646575928, "2003": 0.3519764244556427, "2024": 0.030771657824516296, "2069": 0.05046287178993225, "2109": 0.17431432008743286, "2128": 0.8941729068756104, "2139": 0.045809537172317505, "2156": 0.39367714524269104, "2159": 0.9857001900672913, "223... | 19521501 | Electroretinography (ERG) is an established diagnostic technique in clinical ophthalmology and provides objective information about retinal function. This technique is also applied in basic research, where animal models of hereditary retinopathies have significantly contributed to our understanding of the composition o... | Vision tests in the mouse: Functional phenotyping with electroretinography. |
{"1016": 0.45251765847206116, "1039": 0.3750596046447754, "1047": 0.5882205963134766, "2005": 0.20739519596099854, "2008": 0.010684899985790253, "2011": 0.23787821829319, "2025": 0.03266380727291107, "2029": 0.29109421372413635, "2035": 0.34577593207359314, "2041": 0.021256839856505394, "2043": 0.07250232994556427, "20... | 19522248 | We targeted the locus encoding the cyclin-dependent kinase 2 (CDK2) by homologous recombination in mouse embryonic stem (ES) cells. Embryonic fibroblasts lacking CDK2 proliferate normally and become immortal after continuous passage in culture. Elimination of a conditional Cdk2 allele in immortal cells does not have a ... | Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice |
{"1009": 0.757441520690918, "1011": 0.13670019805431366, "1039": 0.8973627090454102, "1044": 0.10467668622732162, "1047": 0.6233867406845093, "1050": 0.6823468804359436, "2005": 0.16276304423809052, "2007": 0.04207121208310127, "2012": 0.2976420819759369, "2025": 0.09317722171545029, "2029": 0.08871890604496002, "2043"... | 19529370 | Although skeletal pain can have a marked impact on a patient's functional status and quality of life, relatively little is known about the specific populations of peripheral nerve fibers that drive non-malignant bone pain. In the present report, neonatal male Sprague-Dawley rats were treated with capsaicin or vehicle a... | Capsaicin-sensitive sensory nerve fibers contribute to the generation and maintenance of skeletal fracture pain. |
{"1040": 0.9687942266464233, "1043": 0.35403475165367126, "2001": 0.052318159490823746, "2005": 0.23556606471538544, "2013": 0.15777134895324707, "2015": 0.791648268699646, "2042": 0.011650617234408855, "2043": 0.12642613053321838, "2045": 0.09938567131757736, "2062": 0.04953393340110779, "2064": 0.10731173306703568, "... | 19532163 | Surgical treatments for dystonia have been available since the early 20th century, but have improved in their efficacy to adversity ratio through a combination of technologic advances and better understanding of the role of the basal ganglia in dystonia. The word "dystonia" describes a phenotype of involuntary movement... | Surgical therapy for dystonia. |
{"1017": 1.0927356481552124, "1043": 0.37907835841178894, "1049": 0.026025565341114998, "1052": 0.175953671336174, "2003": 0.2026219218969345, "2007": 0.09495500475168228, "2008": 0.007782140281051397, "2029": 0.25467249751091003, "2091": 0.08513788133859634, "2093": 0.6149744987487793, "2098": 0.3005385100841522, "210... | 19541444 | Maternally expressed gene 3 (MEG3) is a maternally expressed imprinted gene representing a large noncoding RNA in which microRNAs (miRNAs) and small nucleolar RNAs are also hosted. It is capable of interacting with cyclic AMP, p53, murine double minute 2 (MDM2) and growth differentiation factor 15 (GDF15) playing a rol... | MEG3 imprinted gene contribution in tumorigenesis. |
{"1047": 0.2622140049934387, "1052": 0.1619328260421753, "1054": 0.06429435312747955, "1997": 0.026025565341114998, "1998": 0.27044451236724854, "2000": 0.02887592278420925, "2002": 0.906871497631073, "2004": 0.2409527748823166, "2007": 0.2976420819759369, "2011": 0.41195443272590637, "2019": 0.3743882179260254, "2029"... | 19546104 | 1. The liver is the target organ for the lipid-regulating effect of rosuvastatin, a new 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, and liver-selective uptake of this drug is therefore a desirable property. The uptake kinetics of rosuvastatin were investigated and compared with those of pravastatin using... | Uptake of rosuvastatin by isolated rat hepatocytes: comparison with pravastatin. |
{"1006": 0.25995752215385437, "1009": 0.6512666940689087, "1011": 0.30989447236061096, "1015": 0.495672345161438, "1016": 0.5882205963134766, "1018": 0.34922540187835693, "1050": 0.23324857652187347, "1056": 0.846739649772644, "1997": 0.06520967930555344, "1998": 0.259204238653183, "1999": 0.18167030811309814, "2007": ... | 19561411 | Orai1 and stromal interaction molecule 1 (STIM1) mediate store-operated Ca(2+) entry (SOCE) in immune cells. STIM1, an endoplasmic reticulum (ER) Ca(2+) sensor, detects store depletion and interacts with plasma membrane (PM)-resident Orai1 channels at the ER-PM junctions. However, the molecular composition of these jun... | Junctophilin-4, a component of the endoplasmic reticulum-plasma membrane junctions, regulates Ca2+ dynamics in T cells. |
{"1011": 0.0058422754518687725, "1015": 0.24554696679115295, "1017": 0.7674643993377686, "1045": 0.5506471395492554, "1047": 0.5690577030181885, "1052": 0.7818660736083984, "1170": 0.06977381557226181, "2003": 0.0842406153678894, "2004": 0.05786345899105072, "2005": 0.27934664487838745, "2008": 0.022212404757738113, "2... | 19565018 | Owing to its widespread activation in inflammation and cancer, a growing appreciation of the therapeutic potential of inhibitors of the phosphoinositide 3-kinase (PI3K) pathway has stimulated intense interest in compounds with suitable pharmacological profiles. These are primarily directed toward PI3K itself. However, ... | The PI3K inhibitor arsenal: choose your weapon! |
{"1021": 0.11778303235769272, "1022": 0.2184450328350067, "1038": 0.8845420479774475, "1040": 0.11343330889940262, "1043": 0.6086184978485107, "1999": 0.36697331070899963, "2004": 0.026976587250828743, "2005": 0.21372433006763458, "2011": 0.3163207769393921, "2071": 0.1401015669107437, "2078": 1.0887986421585083, "2094... | 19571273 | Brain-derived neurotrophic factor (BDNF) regulates synaptic activity and behavioral flexibility, and reduction of BDNF strongly predicts psychiatric disorders and cognitive dysfunction. Restoration of BDNF-dependent activity could alleviate these impairments, but BDNF has limited clinical utility due to its pharmacokin... | Infralimbic BDNF/TrkB enhancement of GluN2B currents facilitates extinction of a cocaine-conditioned place preference. |
{"1011": 0.25239890813827515, "1015": 0.4728073179721832, "1043": 0.09317722171545029, "1052": 0.6482070088386536, "1997": 0.13157635927200317, "1999": 0.06977381557226181, "2005": 0.2689530849456787, "2008": 0.03831886500120163, "2011": 0.2089812457561493, "2013": 0.13499516248703003, "2024": 0.026025565341114998, "20... | 19572798 | Polycomb group (PcG) proteins are required for the epigenetic maintenance of developmental genes in a silent state. Proteins in the Polycomb-repressive complex 1 (PRC1) class of the PcG are conserved from flies to humans and inhibit transcription. One hypothesis for PRC1 mechanism is that it compacts chromatin, based i... | Compaction of chromatin by diverse Polycomb group proteins requires localized regions of high charge. |
{"1009": 0.48970574140548706, "1011": 0.28963330388069153, "1017": 0.306306391954422, "1018": 0.3560888469219208, "1019": 0.020300358533859253, "1021": 0.007782140281051397, "1039": 0.026976587250828743, "1043": 0.31845372915267944, "1044": 0.15693697333335876, "1999": 0.04487626627087593, "2002": 0.19622190296649933, ... | 19583924 | Successful ex vivo expansion of hematopoietic stem cells (HSCs) would greatly benefit the treatment of disease and the understanding of crucial questions of stem cell biology. Here we show, using microarray studies, that the HSC-supportive mouse fetal liver CD3+ cells specifically express the proteins angiopoietin-like... | Angiopoietin-like proteins stimulate ex vivo expansion of hematopoietic stem cells |
{"1011": 0.5104349255561829, "1013": 0.0317181795835495, "1038": 0.7881022095680237, "1044": 0.8877626657485962, "1048": 0.42225050926208496, "1056": 0.7076893448829651, "1998": 0.3656192123889923, "2002": 0.15693697333335876, "2003": 0.08692999184131622, "2007": 0.31204116344451904, "2008": 0.18816383183002472, "2012"... | 19603353 | The interaction between B- and T-lymphocyte attenuator (BTLA), an inhibitory receptor whose extracellular domain belongs to the immunoglobulin superfamily, and herpesvirus-entry mediator (HVEM), a co-stimulatory tumour-necrosis factor receptor, is unique in that it is the only receptor–ligand interaction that directly ... | Balancing co-stimulation and inhibition with BTLA and HVEM |
{"1011": 0.2105647772550583, "1013": 0.06429435312747955, "1016": 0.021256839856505394, "1017": 0.0019512200960889459, "1038": 0.7201237678527832, "1045": 0.5849615335464478, "2002": 0.8057082891464233, "2003": 0.24018502235412598, "2005": 0.371698260307312, "2006": 0.27044451236724854, "2008": 0.2160874605178833, "202... | 19644821 | Lin28a/b are RNA-binding proteins that influence stem cell maintenance, metabolism, and oncogenesis. Poorly differentiated, aggressive cancers often overexpress Lin28, but its role in tumor initiation or maintenance has not been definitively addressed. We report that LIN28B overexpression is sufficient to initiate hepa... | Lin28b is sufficient to drive liver cancer and necessary for its maintenance in murine models. |
{"1996": 0.5528968572616577, "1997": 0.16442140936851501, "2003": 0.2763880789279938, "2024": 0.09761575609445572, "2029": 0.10906458646059036, "2048": 0.37974658608436584, "2049": 0.10379679501056671, "2066": 0.24171993136405945, "2079": 0.11256109178066254, "2092": 0.16359257698059082, "2098": 0.21687394380569458, "2... | 19651306 | The proteasome is a major cytosolic proteolytic assembly, essential for the physiology of eukaryotic cells. Both the architecture and enzymatic properties of the 20S proteasome are relatively well understood. However, despite longstanding interest, the integration of structural and functional properties of the proteaso... | Nanoenzymology of the 20S proteasome: proteasomal actions are controlled by the allosteric transition. |
{"1009": 0.40546512603759766, "1011": 0.03925827145576477, "1013": 0.3409265875816345, "1014": 0.13670019805431366, "1018": 0.24018502235412598, "1020": 0.38905516266822815, "1021": 0.04674193635582924, "1022": 0.06154331564903259, "1023": 0.04860413447022438, "1039": 0.3077431619167328, "1044": 0.38174858689308167, "1... | 19658917 | CONTEXT The measurement of arginine vasopressin (AVP) is often cumbersome because it is unstable with a short half-life time. AVP is derived from a larger precursor peptide along with the more stable peptide copeptin. Copeptin is the C-terminal part of provasopressin and has been shown to be a useful tool to indicate A... | Changes in plasma copeptin, the c-terminal portion of arginine vasopressin during water deprivation and excess in healthy subjects. |
{"1011": 0.17922431230545044, "1038": 0.9470623731613159, "1041": 1.0285027027130127, "1042": 0.8805016279220581, "1043": 0.00875066313892603, "1044": 0.40089741349220276, "1048": 0.3963087201118469, "2000": 0.24859806895256042, "2005": 0.3416208028793335, "2006": 0.0606246218085289, "2007": 0.11604541540145874, "2008"... | 19661996 | With current techniques, genetic alterations of herpesviruses are difficult to perform, mostly because of the large size of their genomes. To solve this problem, we have designed a system that allows the cloning of any gamma-herpesvirus in Escherichia coli onto an F factor-derived plasmid. Immortalized B cell lines wer... | Propagation and recovery of intact, infectious Epstein-Barr virus from prokaryotic to human cells. |
{"1011": 0.09228714555501938, "1014": 0.24554696679115295, "1026": 0.16690383851528168, "1039": 0.3519764244556427, "1040": 0.4914994537830353, "1052": 0.0842406153678894, "1056": 0.06612417846918106, "2000": 0.014542185701429844, "2005": 0.0029254043474793434, "2007": 0.11517547070980072, "2013": 0.11168810725212097, ... | 19673227 | The prognostic value associated with the detection of circulating tumor cells (CTCs) in metastatic breast cancer by the CellSearch technology raise additional issues regarding the biological value of this information. We postulated that a drug-resistance profile of CTCs may predict response to chemotherapy in cancer pa... | Chemosensitivity profile assay of circulating cancer cells: prognostic and predictive value in epithelial tumors. |
{"1003": 0.00875066313892603, "1044": 0.4574742913246155, "1997": 0.025073638185858727, "2001": 0.1485546976327896, "2021": 0.022212404757738113, "2038": 0.1384023278951645, "2039": 0.11778303235769272, "2042": 0.2105647772550583, "2043": 0.14602625370025635, "2044": 0.6941232681274414, "2051": 0.3241194784641266, "205... | 19675911 | CONTEXT The epidemic of heart failure has yet to be fully investigated, and data on incidence, survival, and sex-specific temporal trends in community-based populations are limited. OBJECTIVE To test the hypothesis that the incidence of heart failure has declined and survival after heart failure diagnosis has improved ... | Trends in heart failure incidence and survival in a community-based population. |
{"1022": 0.5220900774002075, "1040": 0.22704219818115234, "1052": 0.20977331697940826, "1060": 0.40285754203796387, "2011": 0.15275461971759796, "2029": 0.23710809648036957, "2079": 0.846739649772644, "2107": 0.18411032855510712, "2109": 0.053244512528181076, "2114": 0.623910129070282, "2140": 0.3910386264324188, "2203... | 19683625 | BACKGROUND Tetracyclines such as doxycycline are reported to possess cytotoxic activity against mammalian tumor cells, but the mechanism of their effects on cell proliferation remains unclear. MATERIALS AND METHODS The antitumor effect of doxycycline was investigated in human pancreatic cancer cell line, PANC-1. We als... | Doxycycline induces apoptosis in PANC-1 pancreatic cancer cells. |
{"1007": 0.011650617234408855, "1017": 0.39367714524269104, "1018": 0.23402166366577148, "1060": 0.058784693479537964, "1999": 0.6086184978485107, "2010": 0.6862877607345581, "2029": 0.026025565341114998, "2062": 0.21372433006763458, "2064": 0.043007105588912964, "2072": 0.40611594915390015, "2084": 0.1751343309879303,... | 19685306 | This paper proposes and tests a technique for imaging orientationally invariant indices of axon diameter and density in white matter using diffusion magnetic resonance imaging. Such indices potentially provide more specific markers of white matter microstructure than standard indices from diffusion tensor imaging. Orie... | Orientationally invariant indices of axon diameter and density from diffusion MRI. |
{"1011": 0.13414156436920166, "1039": 1.072225570678711, "1043": 0.1889725625514984, "1045": 0.20421554148197174, "1157": 0.4574742913246155, "1996": 0.058784693479537964, "1999": 0.02887592278420925, "2005": 0.14179791510105133, "2007": 0.48068851232528687, "2008": 0.045809537172317505, "2011": 0.12384103983640671, "2... | 19688024 | Many human cells can sense the presence of exogenous DNA during infection though the cytosolic DNA receptor cyclic GMP-AMP synthase (cGAS), which produces the second messenger cyclic GMP-AMP (cGAMP). Other putative DNA receptors have been described, but whether their functions are redundant, tissue-specific or integrat... | IFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes |
{"1011": 0.08513788133859634, "1021": 0.24248650670051575, "1049": 0.10818854719400406, "1050": 0.6181373596191406, "1053": 0.0019512200960889459, "1059": 0.7086513638496399, "2006": 0.7220231294631958, "2007": 0.022212404757738113, "2011": 0.09228714555501938, "2012": 0.30989447236061096, "2029": 0.22937409579753876, ... | 19701340 | Melatonin has been shown to have oncostatic effects on malignant melanoma in vitro and in vivo. We studied the growth suppressive effects of melatonin over a wide range of concentrations in four melanoma cell lines (SBCE2, WM-98, WM-164 and SKMEL-188) representative for different growth stages and phenotype. Melanoma c... | Oncostatic effects of the indole melatonin and expression of its cytosolic and nuclear receptors in cultured human melanoma cell lines. |
{"1017": 0.22548456490039825, "1018": 0.4196864068508148, "1048": 0.5618454217910767, "2003": 0.2786078155040741, "2025": 0.0797421783208847, "2029": 0.27342069149017334, "2048": 0.32058215141296387, "2116": 0.018384648486971855, "2128": 0.5707147121429443, "2140": 0.6664261221885681, "2159": 0.5336109399795532, "2170"... | 19708993 | Mucolipidosis type IV is an autosomal recessive lysosomal storage disorder characterized by severe neurodegeneration, achlorhydria, and visual impairments such as corneal opacity and strabismus. The disease arises due to mutations in a group 2 transient receptor potential (TRP)-related cation channel, TRPML1. Mammals e... | Lysosomal localization of TRPML3 depends on TRPML2 and the mucolipidosis-associated protein TRPML1. |
{"1043": 0.371698260307312, "1047": 0.6446255445480347, "1056": 0.4494072198867798, "2011": 0.08961215615272522, "2013": 0.3106105625629425, "2035": 0.5104349255561829, "2045": 0.04113444685935974, "2050": 0.06795065850019455, "2057": 0.05139094591140747, "2061": 0.7370892763137817, "2064": 0.2852376699447632, "2075": ... | 19736671 | Human tumors show a high level of genetic heterogeneity, but the processes that influence the timing and route of metastatic dissemination of the subclones are unknown. Here we have used whole-exome sequencing of 103 matched benign, malignant and metastatic skin tumors from genetically heterogeneous mice to demonstrate... | Evolution of metastasis revealed by mutational landscapes of chemically induced skin cancers |
{"1011": 0.4518963396549225, "1017": 0.8649974465370178, "1018": 0.4794800877571106, "1021": 0.3870677351951599, "1022": 0.4158279001712799, "1047": 0.16690383851528168, "1048": 0.5098485946655273, "1052": 0.40546512603759766, "1056": 0.09672962874174118, "2003": 0.29036402702331543, "2004": 0.3034266233444214, "2007":... | 19752008 | Phosphatidylinositol (PtdIns) 3-kinase is an enzyme implicated in growth factor signal transduction by associating with receptor and nonreceptor tyrosine kinases, including the platelet-derived growth factor receptor. Inhibitors of PtdIns 3-kinase could potentially give a better understanding of the function and regula... | A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). |
{"1011": 0.27934664487838745, "1023": 0.890972912311554, "1052": 0.026025565341114998, "1156": 0.23864774405956268, "1999": 0.05046287178993225, "2000": 0.21530038118362427, "2005": 0.23247487843036652, "2011": 0.28082266449928284, "2029": 0.10731173306703568, "2041": 0.11256109178066254, "2050": 0.5795059204101562, "2... | 19756935 | Isolated pure human beta cells would be helpful for a number of research purposes. However, lack of beta cell-specific surface antigens has been a major problem. We aimed to develop a simple method for human beta cell isolation based on the initial elimination of ductal cells by their expression of carbohydrate antigen... | A simple two-step protocol for the purification of human pancreatic beta cells |
{"1011": 0.20501139760017395, "1017": 0.2018241584300995, "1996": 0.018384648486971855, "1999": 0.02887592278420925, "2003": 0.16442140936851501, "2008": 0.14433705806732178, "2013": 0.11778303235769272, "2024": 0.3930181860923767, "2029": 0.2247048318386078, "2031": 0.14264501631259918, "2033": 0.34370049834251404, "2... | 19770974 | Human blastocyst-derived, pluripotent cell lines are described that have normal karyotypes, express high levels of telomerase activity, and express cell surface markers that characterize primate embryonic stem cells but do not characterize other early lineages. After undifferentiated proliferation in vitro for 4 to 5 m... | Prev | Table of Contents Reports Embryonic Stem Cell Lines Derived from Human |
{"1038": 0.5461324453353882, "1039": 1.1437997817993164, "1999": 0.2561853528022766, "2004": 0.9440274834632874, "2005": 0.39893341064453125, "2011": 0.06977381557226181, "2013": 0.04394211992621422, "2020": 0.09495500475168228, "2025": 0.0913962796330452, "2029": 0.09761575609445572, "2030": 0.3916989266872406, "2044"... | 19799455 | The only proven requirement for ascorbic acid (vitamin C) is in preventing scurvy, presumably because it is a cofactor for hydroxylases required for post-translational modifications that stabilize collagen. We have created mice deficient in the mouse ortholog (solute carrier family 23 member 1 or Slc23a1) of a rat asco... | Ascorbic-acid transporter Slc23a1 is essential for vitamin C transport into the brain and for perinatal survival |
{"1011": 0.21214580535888672, "1039": 0.31845372915267944, "1041": 0.4145384132862091, "1043": 0.3777405619621277, "1996": 0.0058422754518687725, "1999": 0.15693697333335876, "2007": 0.3262358605861664, "2024": 0.2501201331615448, "2026": 0.7592713832855225, "2029": 0.21922965347766876, "2039": 0.5540198087692261, "204... | 19800147 | Exosomes are emerging mediators of intercellular communication; whether the release of exosomes has an effect on the exosome donor cells in addition to the recipient cells has not been investigated to any extent. Here, we examine different exosomal miRNA expression profiles in primary mouse colon tumour, liver metastas... | MVP-mediated exosomal sorting of miR-193a promotes colon cancer progression |
{"1014": 0.29619070887565613, "1023": 0.175953671336174, "1041": 0.857568621635437, "1044": 0.3956514894962311, "1047": 0.01934296265244484, "1052": 0.3963087201118469, "1053": 0.040196798741817474, "1054": 0.5027855634689331, "1156": 0.6793810129165649, "1609": 0.48068851232528687, "2001": 0.5756692886352539, "2007": ... | 19804204 | BACKGROUND AND OBJECTIVES Children with chronic kidney disease (CKD) are at risk for cognitive dysfunction, and over half have hypertension. Data on the potential contribution of hypertension to CKD-associated neurocognitive deficits in children are limited. Our objective was to determine whether children with CKD and ... | Casual blood pressure and neurocognitive function in children with chronic kidney disease: a report of the children with chronic kidney disease cohort study. |
{"1006": 0.15526613593101501, "1011": 0.36900100111961365, "1037": 0.06154331564903259, "1040": 0.11168810725212097, "1052": 0.15275461971759796, "2003": 0.21765978634357452, "2008": 0.09672962874174118, "2015": 0.036437395960092545, "2029": 0.10555581003427505, "2064": 0.2089812457561493, "2078": 1.3393092155456543, "... | 19822046 | BACKGROUND Deadenylation regulates RNA function and fate. Poly(A)-specific ribonuclease (PARN) is a deadenylase that processes mRNAs and non-coding RNA. Little is known about the biological significance of germline mutations in PARN. METHODS We identified mutations in PARN in patients with haematological and neurologic... | Bone marrow failure and developmental delay caused by mutations in poly(A)-specific ribonuclease (PARN). |
{"1014": 0.2447827309370041, "1019": 0.5596157908439636, "2001": 0.255429208278656, "2020": 0.0797421783208847, "2038": 0.0009760859538801014, "2042": 0.18978065252304077, "2043": 0.36290550231933594, "2045": 0.2223619967699051, "2051": 0.1011524572968483, "2065": 0.6522845029830933, "2073": 0.304147332906723, "2085": ... | 19824183 | Between 1995 and 2000 there were marked changes in the epidemiology of malaria in Ifakara, southern Tanzania. We documented these changes using parasitological and clinical data from a series of community- and hospital-based studies involving children up to the age of 5 years. There was a right shift and lowering in th... | The changing epidemiology of malaria in Ifakara Town, southern Tanzania. |
{"1011": 0.3283478021621704, "1015": 0.24325250089168549, "1017": 0.14433705806732178, "1040": 1.0101795196533203, "1041": 0.39433568716049194, "1043": 0.2231435477733612, "1056": 0.8973627090454102, "1998": 0.0606246218085289, "1999": 0.09495500475168228, "2004": 0.12986256182193756, "2007": 0.1485546976327896, "2011"... | 19828689 | Key features of diabetic nephropathy (DN) include the accumulation of extracellular matrix proteins such as collagen 1-alpha 1 and -2 (Col1a1 and -2). Transforming growth factor beta1 (TGF-beta), a key regulator of these extracellular matrix genes, is increased in mesangial cells (MC) in DN. By microarray profiling, we... | MicroRNA-192 in diabetic kidney glomeruli and its function in TGF-beta-induced collagen expression via inhibition of E-box repressors. |
{"1006": 0.26820653676986694, "1011": 0.1401015669107437, "1016": 0.6410312056541443, "1042": 0.4855078160762787, "1052": 0.12814582884311676, "1054": 0.7881022095680237, "1081": 0.6744182109832764, "2005": 0.026976587250828743, "2007": 0.10993985831737518, "2011": 0.12728634476661682, "2012": 0.09228714555501938, "202... | 19843244 | BACKGROUND AND PURPOSE The PAR(2) receptors are involved in chronic arthritis by mechanisms that are as yet unclear. Here, we examined PAR(2) activation in the rat knee joint. EXPERIMENTAL APPROACH PAR(2) in rat knee joint dorsal root ganglia (DRG) cells at L3-L5, retrogradely labelled with Fluoro-gold (FG) were demons... | Activation of PAR(2) receptors sensitizes primary afferents and causes leukocyte rolling and adherence in the rat knee joint. |
{"1011": 0.029824240133166313, "1015": 0.1212492436170578, "1041": 0.03266380727291107, "1048": 0.33953672647476196, "1049": 0.4487839937210083, "1052": 0.848413348197937, "2007": 0.10555581003427505, "2011": 0.15860503911972046, "2012": 0.2516399025917053, "2015": 0.11951763927936554, "2026": 0.9915141463279724, "2029... | 19851614 | Polyphosphate (poly P) metabolism regulates the stress response in mycobacteria. Here we describe the regulatory architecture of a signal transduction system involving the two-component system (TCS) SenX3-RegX3, the extracytoplasmic function sigma factor sigma E (SigE) and the poly P-synthesizing enzyme polyphosphate k... | Polyphosphate kinase 1, a central node in the stress response network of Mycobacterium tuberculosis, connects the two-component systems MprAB and SenX3-RegX3 and the extracytoplasmic function sigma factor, sigma E. |
{"1013": 0.17020416259765625, "1019": 0.10291612148284912, "1020": 0.19622190296649933, "1026": 0.08782484382390976, "1050": 0.3995884954929352, "1052": 0.5027855634689331, "1177": 0.5450005531311035, "1997": 0.1677299439907074, "2004": 0.5336109399795532, "2019": 0.848413348197937, "2039": 0.319873183965683, "2050": 0... | 19854543 | PURPOSE To characterize the relationship between aneurysm size and epidemiologic risk factors with growth and rupture by using computed tomographic (CT) angiography. MATERIALS AND METHODS In this HIPAA-compliant, institutional review board approved study, patients with known asymptomatic unruptured intracerebral aneury... | Natural history of asymptomatic unruptured cerebral aneurysms evaluated at CT angiography: growth and rupture incidence and correlation with epidemiologic risk factors. |
{"1015": 0.6107416749000549, "1017": 0.18492233753204346, "1038": 0.9100211262702942, "1058": 0.23092569410800934, "1999": 0.009718249551951885, "2001": 0.15693697333335876, "2006": 0.16524957120418549, "2011": 0.25088030099868774, "2012": 0.07068414986133575, "2013": 0.2637155055999756, "2020": 0.176772341132164, "202... | 19854744 | Using an antiserum raised to a recombinant coxsackie virus B3 capsid protein, VP1, an immunocytochemical technique was developed which was capable of detecting the presence of all coxsackie B viruses in formalin fixed paraffin embedded infected tissue culture cells. This technique was tested on autopsy heart and pancre... | A search for the presence of the enteroviral capsid protein VP1 in pancreases of patients with Type 1 (insulin-dependent) diabetes and pancreases and hearts of infants who died of coxsackieviral myocarditis |
{"1011": 0.20022670924663544, "1038": 0.5191890001296997, "1040": 0.0174254160374403, "1041": 0.22392450273036957, "1043": 0.6043586730957031, "1054": 0.5404602885246277, "1056": 0.058784693479537964, "1155": 0.48670899868011475, "2000": 0.2983669638633728, "2004": 0.14518201351165771, "2005": 0.1358480453491211, "2006... | 19855358 | Direct reprogramming strategies enable rapid conversion of somatic cells to cardiomyocytes or cardiomyocyte-like cells without going through the pluripotent state. A recently described protocol couples Yamanaka factor induction with pluripotency inhibition followed by BMP4 treatment to achieve rapid reprogramming of mo... | Direct reprogramming of mouse fibroblasts to cardiomyocyte-like cells using Yamanaka factors on engineered poly(ethylene glycol) (PEG) hydrogels. |
{"1013": 0.21372433006763458, "1019": 0.01934296265244484, "1040": 0.8238670229911804, "1045": 0.3662964701652527, "1051": 0.07884006202220917, "1052": 0.41840189695358276, "1060": 0.24171993136405945, "2003": 0.16524957120418549, "2004": 0.4728073179721832, "2005": 0.37102460861206055, "2012": 0.06795065850019455, "20... | 19878070 | CONTEXT Risedronate, a potent bisphosphonate, has been shown to be effective in the treatment of Paget disease of bone and other metabolic bone diseases but, to our knowledge, it has not been evaluated in the treatment of established postmenopausal osteoporosis. OBJECTIVE To test the efficacy and safety of daily treatm... | Effects of risedronate treatment on vertebral and nonvertebral fractures in women with postmenopausal osteoporosis: a randomized controlled trial. Vertebral Efficacy With Risedronate Therapy (VERT) Study Group. |
{"1011": 0.014542185701429844, "1044": 0.6902132034301758, "2003": 0.0019512200960889459, "2005": 0.0174254160374403, "2025": 0.006812678650021553, "2038": 0.02792670577764511, "2043": 0.04113444685935974, "2053": 0.151916041970253, "2064": 0.02887592278420925, "2076": 0.1011524572968483, "2079": 0.25467249751091003, "... | 19882228 | Cells undergo a variety of biological responses when placed in hypoxic conditions, including activation of signalling pathways that regulate proliferation, angiogenesis and death. Cancer cells have adapted these pathways, allowing tumours to survive and even grow under hypoxic conditions, and tumour hypoxia is associat... | Hypoxia — a key regulatory factor in tumour growth |
{"1042": 1.1300151348114014, "1052": 0.29255300760269165, "1996": 0.319873183965683, "1999": 0.08961215615272522, "2013": 0.10026945173740387, "2015": 0.40871503949165344, "2029": 0.0913962796330452, "2061": 0.8013357520103455, "2066": 0.09938567131757736, "2073": 0.006812678650021553, "2078": 1.0546929836273193, "2083... | 19912367 | Age-related changes in the niche have long been postulated to impair the function of somatic stem cells. Here we demonstrate that the aged stem cell niche in skeletal muscle contains substantially reduced levels of fibronectin (FN), leading to detrimental consequences for the function and maintenance of muscle stem cel... | Loss of fibronectin from the aged stem cell niche affects the regenerative capacity of skeletal muscle in mice |
{"1051": 0.6674286723136902, "1054": 0.35403475165367126, "1055": 0.17840765416622162, "2015": 1.1444218158721924, "2029": 0.15610189735889435, "2061": 0.05786345899105072, "2071": 0.3304552733898163, "2076": 0.2749055027961731, "2079": 0.2105647772550583, "2080": 0.3547199070453644, "2104": 0.03925827145576477, "2109"... | 19922508 | Reactive oxygen species (ROS) are potentially harmful to cells because of their ability to oxidize cell constituents such as DNA, proteins, and lipids. However, at low levels, and under tight control, this feature makes them excellent modifiers in a variety of signal transduction pathways, including autophagy. Autophag... | Monitoring starvation-induced reactive oxygen species formation. |
{"1003": 0.20660123229026794, "1014": 0.4431571960449219, "1017": 0.20580662786960602, "1018": 0.25995752215385437, "1020": 0.19782574474811554, "1021": 0.34922540187835693, "1041": 0.19782574474811554, "1043": 0.1229778528213501, "1053": 0.4855078160762787, "1997": 0.39696553349494934, "2007": 0.2089812457561493, "202... | 19945096 | OBJECTIVES To describe and explain the primary care experiences of people with multiple long-term conditions in England. DESIGN AND METHODS Using questionnaire data from 906,578 responders to the English 2012 General Practice Patient Survey, we describe the primary care experiences of patients with long-term conditions... | Why do patients with multimorbidity in England report worse experiences in primary care? Evidence from the General Practice Patient Survey |
{"1017": 0.3601844012737274, "1041": 0.06612417846918106, "1052": 0.40285754203796387, "2003": 0.2969166338443756, "2008": 0.014542185701429844, "2011": 0.29255300760269165, "2029": 0.1619328260421753, "2050": 0.732405424118042, "2054": 0.040196798741817474, "2078": 0.2184450328350067, "2079": 0.15943801403045654, "209... | 19950357 | Auxin is a fundamental plant hormone and its localization within organs plays pivotal roles in plant growth and development. Analysis of many Arabidopsis mutants that were defective in auxin biosynthesis revealed that the indole-3-pyruvic acid (IPA) pathway, catalyzed by the TRYPTOPHAN AMINOTRANSFERASE OF ARABIDOPSIS (... | The rice FISH BONE gene encodes a tryptophan aminotransferase, which affects pleiotropic auxin-related processes. |
{"1003": 0.07068414986133575, "1018": 0.055094651877880096, "1019": 0.10906458646059036, "1020": 0.3930181860923767, "1037": 0.4067663550376892, "1038": 0.6989894509315491, "2000": 0.0913962796330452, "2005": 0.3283478021621704, "2013": 0.4145384132862091, "2029": 0.16524957120418549, "2034": 0.42735910415649414, "2038... | 19951373 | Although the somatic cloning technique has been used for numerous applications and basic research of reprogramming in various species, extremely low success rates have plagued this technique for a decade. Further in mice, the "clonable" strains have been limited to mainly hybrid F1 strains such as B6D2F1. Recently, we ... | Successful mouse cloning of an outbred strain by trichostatin A treatment after somatic nuclear transfer. |
{"1051": 0.5347557663917542, "1052": 0.2711893916130066, "1054": 0.5800528526306152, "2003": 0.28450319170951843, "2005": 0.19220098853111267, "2013": 0.08513788133859634, "2029": 0.1212492436170578, "2057": 0.09050461649894714, "2064": 0.08603433519601822, "2076": 0.0038986403960734606, "2080": 0.5957841277122498, "20... | 19957813 | Oxidative phosphorylation (OXPHOS) is the major pathway for ATP production in humans. Deficiencies in OXPHOS can arise from mutations in either mitochondrial or nuclear genomes and comprise the largest collection of inborn errors of metabolism. At present we lack a complete catalog of human genes and pathways essential... | A Genome-wide CRISPR Death Screen Identifies Genes Essential for Oxidative Phosphorylation. |
{"1017": 0.018384648486971855, "1044": 0.3070250153541565, "1053": 0.4574742913246155, "1054": 0.5540198087692261, "1055": 0.49864232540130615, "2002": 0.9717550277709961, "2005": 0.045809537172317505, "2010": 0.05417001247406006, "2024": 0.1384023278951645, "2029": 0.22001366317272186, "2035": 0.32058215141296387, "20... | 19958277 | RecQ helicases are highly conserved from bacteria to man. Germline mutations in three of the five known family members in humans give rise to debilitating disorders that are characterized by, amongst other things, a predisposition to the development of cancer. One of these disorders — Bloom's syndrome — is uniquely ass... | RecQ helicases: caretakers of the genome |
{"1014": 0.6212902665138245, "1018": 0.37974658608436584, "1041": 0.25088030099868774, "1997": 0.2674594223499298, "2001": 0.32129061222076416, "2013": 0.26446542143821716, "2020": 0.17020416259765625, "2025": 0.33675122261047363, "2035": 0.5795059204101562, "2042": 0.037378571927547455, "2043": 0.4203280806541443, "20... | 19961177 | OBJECTIVE To investigate comparative national trends in mortality from conditions amenable to timely, appropriate medical care and from those considered not to be amenable to such care. DESIGN Analysis of trends in direct age standardised mortality from the 1950s to 1987. SETTING Four eastern European nations (Hungary,... | Mortality from causes amenable and non-amenable to medical care: the experience of eastern Europe. |
{"1011": 0.2223619967699051, "1015": 0.00875066313892603, "1020": 0.3353555500507355, "1023": 0.3676496744155884, "1044": 0.6070231795310974, "1048": 0.3283478021621704, "1997": 0.09495500475168228, "1999": 0.11604541540145874, "2003": 0.19862671196460724, "2007": 0.0842406153678894, "2008": 0.053244512528181076, "2010... | 19966976 | Heterochromatin is characterized by methylation of histone H3 at lysine 9, which is recognized by well-conserved HP1-family proteins. Heterochromatin participates in various chromosome functions, which include transcriptional gene silencing and sister-chromatid cohesion. These heterochromatic functions are carried out ... | Dynamic regulation of heterochromatin function via phosphorylation of HP1-family proteins. |
{"1011": 0.306306391954422, "1017": 0.15943801403045654, "1055": 0.026025565341114998, "1056": 0.9754437208175659, "2007": 0.04394211992621422, "2011": 0.12038381397724152, "2015": 0.8143964409828186, "2029": 0.1619328260421753, "2033": 0.6950984001159668, "2046": 0.2516399025917053, "2076": 0.3923587501049042, "2078":... | 19970015 | Down syndrome (DS), or Trisomy 21 (T21) syndrome, one of the most common chromosomal abnormalities, is caused by an extra duplication of chromosome 21. In studies of neuron development, experimental models based on human cells are considered to be the most desired and accurate for basic research. The generation of dise... | Modeling neurogenesis impairment in Down syndrome with induced pluripotent stem cells from Trisomy 21 amniotic fluid cells. |
{"1011": 0.11168810725212097, "1015": 0.255429208278656, "1021": 0.06886265426874161, "1043": 0.5849615335464478, "1055": 0.31132611632347107, "1996": 0.10731173306703568, "1997": 0.15275461971759796, "2002": 0.5800528526306152, "2011": 0.10026945173740387, "2012": 0.06795065850019455, "2013": 0.3464667797088623, "2015... | 19974105 | DNA replication is precisely regulated in time and space, thereby safeguarding genomic integrity. In eukaryotes, replication initiates from multiple sites along the genome, termed origins of replication, and propagates bidirectionally. Dynamic origin bound complexes dictate where and when replication should initiate. D... | Control over DNA replication in time and space. |
{"1038": 0.6654226183891296, "1048": 0.1685553640127182, "1996": 0.2478361576795578, "1998": 0.5010119676589966, "2007": 0.056018441915512085, "2010": 0.21530038118362427, "2012": 0.2786078155040741, "2026": 1.3489859104156494, "2029": 0.2231435477733612, "2033": 0.29036402702331543, "2051": 0.44691193103790283, "2054"... | 19979816 | The circadian clock and the cell cycle are major cellular systems that organize global physiology in temporal fashion. It seems conceivable that the potentially conflicting programs are coordinated. We show here that overexpression of MYC in U2OS cells attenuates the clock and conversely promotes cell proliferation whi... | MYC/MIZ1-dependent gene repression inversely coordinates the circadian clock with cell cycle and proliferation |
{"1009": 0.5596157908439636, "1011": 0.01934296265244484, "1014": 0.1485546976327896, "1015": 0.1221139207482338, "1017": 0.22392450273036957, "1020": 0.10731173306703568, "1026": 0.058784693479537964, "1052": 0.6553317308425903, "2004": 1.004473328590393, "2007": 0.007782140281051397, "2018": 0.083342544734478, "2019"... | 19994006 | The prognosis of patients manifesting prolonged asystole during head-up tilt testing is unclear. In 209 consecutive patients with a history of syncope and positive head-up tilt tests, 19 had asystole lasting > 5 seconds (mean duration 15 +/- 10) (group 1a). When compared with patients without asystole (group 1b), group... | Relevance of asystole during head-up tilt testing. |
{"1011": 0.020300358533859253, "1017": 0.24325250089168549, "1018": 0.12728634476661682, "1020": 0.1332872211933136, "1041": 0.07068414986133575, "2000": 0.19622190296649933, "2001": 0.16524957120418549, "2004": 0.10203468054533005, "2020": 0.06886265426874161, "2022": 0.14179791510105133, "2035": 0.1873544454574585, "... | 20008796 | OBJECTIVE To report data relating to the informed uptake of screening tests. SEARCH STRATEGY Electronic databases, bibliographies and experts were used to identify relevant published and unpublished studies up until August 2000. INCLUSION CRITERIA RCTs, quasi-RCTs and controlled trials of interventions aimed at increas... | Increasing informed uptake and non-uptake of screening: evidence from a systematic review. |
{"1011": 0.05970508232712746, "1018": 0.2539152204990387, "1047": 0.17020416259765625, "1996": 0.09228714555501938, "1997": 0.007782140281051397, "1999": 0.07431721687316895, "2002": 0.6400018334388733, "2005": 0.09938567131757736, "2008": 0.016465263441205025, "2011": 0.26820653676986694, "2015": 0.05046287178993225, ... | 20018321 | Cytoplasmic RNA granules play a central role in mRNA metabolism, but the importance of mitochondrial RNA granules remains relatively unexplored. We characterized their proteome and found that they contain a large toolbox of proteins dedicated to RNA metabolism. Investigation of four uncharacterized putative RNA-binding... | Mitochondrial RNA Granules Are Centers for Posttranscriptional RNA Processing and Ribosome Biogenesis. |
{"1050": 0.26296505331993103, "1996": 0.15442965924739838, "2003": 0.0029254043474793434, "2004": 0.025073638185858727, "2005": 0.2145126610994339, "2011": 0.09050461649894714, "2037": 0.22626367211341858, "2053": 0.0058422754518687725, "2064": 0.08244366943836212, "2076": 0.12470348179340363, "2079": 0.497455388307571... | 20028729 | Nuclear receptors regulate many biologically important processes in development and homeostasis by their bimodal function as repressors and activators of gene transcription. A finely tuned modulation of the transcriptional activities of nuclear receptors is crucial for determining highly specific and diversified progra... | Controlling nuclear receptors: the circular logic of cofactor cycles |
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