spalde-v3-lexical stringlengths 4.95k 41.3k | _id stringlengths 4 9 | text stringlengths 174 10k | title stringlengths 2 300 |
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{"1003": 0.013579257763922215, "1011": 0.2317005842924118, "1013": 0.39762192964553833, "1037": 0.13071982562541962, "1043": 0.0058422754518687725, "1056": 0.8039615154266357, "1996": 0.04860413447022438, "2003": 0.029824240133166313, "2024": 0.04394211992621422, "2029": 0.22937409579753876, "2031": 0.2447827309370041,... | 3367829 | Despite being one of the first eukaryotic transcriptional regulatory elements identified, the sequence of a native TATA box and its significance remain elusive. Applying criteria associated with TATA boxes we queried several Saccharomyces genomes and arrived at the consensus TATA(A/T)A(A/T)(A/G). Approximately 20% of y... | Identification and distinct regulation of yeast TATA box-containing genes. |
{"1011": 0.11168810725212097, "1017": 0.21214580535888672, "1020": 0.5936289429664612, "1021": 0.347847044467926, "1039": 0.9279413223266602, "1041": 0.2674594223499298, "1060": 0.49982786178588867, "1164": 0.4673144817352295, "2005": 0.08692999184131622, "2007": 0.08782484382390976, "2011": 0.0913962796330452, "2029":... | 3376731 | Various factors and cellular components in the tumor microenvironment are key drivers associated with drug resistance in many cancers. Here, we analyzed the factors and molecular mechanisms involved in chemoresistance in patients with esophageal squamous cell carcinoma (ESCC). We found that interleukin 6 (IL6) derived ... | IL6 derived from cancer-associated fibroblasts promotes chemoresistance via CXCR7 in esophageal squamous cell carcinoma |
{"1044": 0.3923587501049042, "1049": 0.3615458607673645, "1055": 0.46117570996284485, "2002": 0.0797421783208847, "2003": 0.3923587501049042, "2015": 0.9302552938461304, "2024": 0.3388410806655884, "2026": 1.1911962032318115, "2033": 0.7987030148506165, "2063": 0.0354953333735466, "2064": 0.0038986403960734606, "2080":... | 3391547 | Myelodysplastic syndromes are a heterogeneous group of diseases characterized by ineffective hematopoiesis and the propensity to leukemic transformation. Their pathogenesis is complex and likely depends on interplay between aberrant hematopoietic cells and their microenvironment. How niche cells play a role in disease ... | Myelodysplastic syndromes: revisiting the role of the bone marrow microenvironment in disease pathogenesis |
{"1011": 0.2689530849456787, "1039": 0.4267219603061676, "1055": 0.32129061222076416, "1997": 0.2478361576795578, "1998": 0.1751343309879303, "1999": 0.10993985831737518, "2005": 0.08513788133859634, "2011": 0.04487626627087593, "2029": 0.3262358605861664, "2048": 0.5398913025856018, "2075": 0.42096930742263794, "2076"... | 3400973 | Structural maintenance of chromosomes (SMC) protein complexes are key determinants of chromosome conformation. Using Hi-C and polymer modelling, we study how cohesin and condensin, two deeply conserved SMC complexes, organize chromosomes in the budding yeast Saccharomyces cerevisiae. The canonical role of cohesin is to... | SMC complexes differentially compact mitotic chromosomes according to genomic context |
{"1003": 0.31132611632347107, "1008": 0.08064348995685577, "1039": 0.06520967930555344, "1062": 0.23633737862110138, "2005": 0.034552380442619324, "2018": 0.040196798741817474, "2022": 0.025073638185858727, "2025": 0.09850110858678818, "2041": 0.12986256182193756, "2042": 0.13670019805431366, "2051": 0.2539152204990387... | 3413083 | BACKGROUND Following widespread rollout of chlamydia testing to non-specialist and community settings in the UK, many individuals receive a chlamydia test without being offered comprehensive STI and HIV testing. We assess sexual behaviour among testers in different settings with a view to understanding their need for o... | Patterns of chlamydia testing in different settings and implications for wider STI diagnosis and care: a probability sample survey of the British population |
{"1016": 0.347847044467926, "2000": 0.15359249711036682, "2002": 0.5827828645706177, "2003": 0.27342069149017334, "2005": 0.417115718126297, "2011": 0.13925230503082275, "2069": 0.10906458646059036, "2093": 0.04953393340110779, "2094": 0.8813109993934631, "2109": 0.3560888469219208, "2243": 1.1665629148483276, "2278": ... | 3419709 | Nonalcoholic fatty liver disease (NAFLD) is a growing worldwide epidemic and an important risk factor for the development of insulin resistance, type 2 diabetes, nonalcoholic steatohepatitis (NASH), and hepatic cellular carcinoma (HCC). Despite the prevalence of NAFLD, lifestyle interventions involving exercise and wei... | Treatment of nonalcoholic fatty liver disease: role of AMPK. |
{"1060": 0.9394577741622925, "1998": 0.040196798741817474, "1999": 0.32905077934265137, "2007": 0.3283478021621704, "2011": 0.045809537172317505, "2013": 0.13071982562541962, "2015": 0.06886265426874161, "2026": 0.9013357162475586, "2029": 0.14179791510105133, "2033": 0.07884006202220917, "2045": 0.34508460760116577, "... | 3419802 | Most human cancers, including myeloma, are preceded by a precursor state. There is an unmet need for in vivo models to study the interaction of human preneoplastic cells in the bone marrow microenvironment with non-malignant cells. Here, we genetically humanized mice to permit the growth of primary human preneoplastic ... | Microenvironment-dependent growth of pre-neoplastic and malignant plasma cells in humanized mice |
{"1014": 0.2969166338443756, "1026": 0.04767346754670143, "1052": 1.0920805931091309, "1053": 0.09938567131757736, "1054": 0.5860490798950195, "1061": 0.2447827309370041, "1999": 0.006812678650021553, "2002": 0.1710275560617447, "2007": 0.16359257698059082, "2011": 0.13157635927200317, "2041": 0.1510767638683319, "2044... | 3430789 | The present study retrospectively analyzed 19 patients diagnosed with paraquat (PQ) poisoning with the aim to investigate the effect of activated charcoal hemoperfusion on renal function and PQ elimination. The results indicated that 7 patients died and 12 survived. Non-oliguric renal failure occurred in all of the 7 p... | Effect of activated charcoal hemoperfusion on renal function in patients with paraquat poisoning. |
{"1040": 0.12470348179340363, "1043": 0.2837681770324707, "1044": 0.20977331697940826, "2007": 0.0770333781838417, "2011": 0.12470348179340363, "2015": 0.7239188551902771, "2019": 0.25995752215385437, "2064": 0.034552380442619324, "2071": 0.09317722171545029, "2076": 0.791648268699646, "2077": 0.02887592278420925, "209... | 3435889 | Diabetes mellitus during pregnancy is a considerable medical challenge, since it is related to augmented morbidity and mortality concerns for both the fetus and the pregnant woman. Records show that the etiology of diabetic embryopathy is complicated, as many teratological factors might be involved in the mechanism... | Diabetes-induced effects on cardiomyocytes in chick embryonic heart micromass and mouse embryonic D3 differentiated stem cells. |
{"2000": 0.3084607720375061, "2003": 0.3353555500507355, "2041": 0.4425300657749176, "2051": 0.3084607720375061, "2054": 0.15693697333335876, "2057": 0.23479416966438293, "2058": 0.27044451236724854, "2064": 0.22001366317272186, "2066": 0.18004031479358673, "2075": 0.07159364968538284, "2079": 0.15526613593101501, "210... | 3437084 | We present motion magnification, a technique that acts like a microscope for visual motion. It can amplify subtle motions in a video sequence, allowing for visualization of deformations that would otherwise be invisible. To achieve motion magnification, we need to accurately measure visual motions, and group the pixels... | Motion magnification |
{"1009": 0.5347557663917542, "1015": 0.679875910282135, "1048": 0.3499138653278351, "1052": 0.16359257698059082, "1056": 0.30558720231056213, "1996": 0.0606246218085289, "2002": 0.15275461971759796, "2003": 0.2983669638633728, "2008": 0.18654440343379974, "2028": 0.2837681770324707, "2029": 0.17840765416622162, "2063":... | 3441524 | Transient receptor potential mucolipin 1 (TRPML1) is a Ca2+-releasing cation channel that mediates the calcium signalling and homeostasis of lysosomes. Mutations in TRPML1 lead to mucolipidosis type IV, a severe lysosomal storage disorder. Here we report two electron cryo-microscopy structures of full-length human TRPM... | Human TRPML1 channel structures in open and closed conformations |
{"1012": 0.07159364968538284, "1041": 0.07884006202220917, "1043": 0.512191891670227, "1045": 1.0782235860824585, "1048": 0.5729197263717651, "1058": 0.6502478122711182, "2003": 0.2954642176628113, "2008": 0.02412080205976963, "2054": 0.083342544734478, "2109": 0.3170322775840759, "2140": 0.3588210940361023, "2152": 0.... | 3444507 | Data visualization is an essential component of genomic data analysis. However, the size and diversity of the data sets produced by today's sequencing and array-based profiling methods present major challenges to visualization tools. The Integrative Genomics Viewer (IGV) is a high-performance viewer that efficiently ha... | Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration |
{"1011": 0.015504186972975731, "2003": 0.15777134895324707, "2005": 0.07884006202220917, "2011": 0.3325583338737488, "2045": 0.04953393340110779, "2047": 0.022212404757738113, "2064": 0.083342544734478, "2071": 0.2837681770324707, "2075": 0.5045560002326965, "2079": 0.272677481174469, "2089": 0.17759032547473907, "2094... | 3446400 | Transcriptional misregulation is involved in the development of many diseases, especially neoplastic transformation. Distal regulatory elements, such as enhancers, play a major role in specifying cell-specific transcription patterns in both normal and diseased tissues, suggesting that enhancers may be prime targets for... | Can genome engineering be used to target cancer-associated enhancers? |
{"1011": 0.03266380727291107, "1014": 0.01934296265244484, "1015": 0.44566190242767334, "1023": 0.04207121208310127, "1038": 0.5723689198493958, "1039": 0.21135559678077698, "1048": 0.5990082025527954, "1056": 0.9440274834632874, "1062": 0.0058422754518687725, "1513": 0.10203468054533005, "1609": 0.24171993136405945, "... | 3462075 | Background CD19‐specific chimeric antigen receptor (CAR) T cells induce high rates of initial response among patients with relapsed B‐cell acute lymphoblastic leukemia (ALL) and long‐term remissions in a subgroup of patients. Methods We conducted a phase 1 trial involving adults with relapsed B‐cell ALL who received an... | Long‐Term Follow‐up of CD19 CAR Therapy in Acute Lymphoblastic Leukemia |
{"1011": 0.04860413447022438, "1038": 0.7463917136192322, "1998": 0.21530038118362427, "1999": 0.029824240133166313, "2007": 0.06520967930555344, "2011": 0.0009760859538801014, "2013": 0.3027053773403168, "2029": 0.3443928062915802, "2033": 0.5914691090583801, "2044": 0.05786345899105072, "2064": 0.2501201331615448, "2... | 3464191 | Bone regeneration relies on the activation of skeletal stem cells (SSCs) that still remain poorly characterized. Here, we show that periosteum contains SSCs with high bone regenerative potential compared to bone marrow stromal cells/skeletal stem cells (BMSCs) in mice. Although periosteal cells (PCs) and BMSCs are deri... | Periosteum contains skeletal stem cells with high bone regenerative potential controlled by Periostin |
{"1042": 0.09050461649894714, "1043": 0.732405424118042, "1044": 0.5104349255561829, "1996": 0.1970241367816925, "1998": 0.3269403576850891, "2002": 0.9987343549728394, "2007": 0.19782574474811554, "2008": 0.018384648486971855, "2010": 0.0038986403960734606, "2011": 0.16359257698059082, "2029": 0.20022670924663544, "20... | 3468459 | Mammalian cells depend on growth factor signaling to take up nutrients; however, coordination of glucose and glutamine uptake has been a mystery. In this issue of Genes & Development, Wellen and colleagues (pp. 2784-2799) show that glucose flux through the hexosamine biosynthesis pathway regulates growth factor recepto... | Metabolism strikes back: metabolic flux regulates cell signaling. |
{"1011": 0.48068851232528687, "1015": 0.7445381283760071, "1017": 0.007782140281051397, "1052": 0.38308101892471313, "1062": 0.02412080205976963, "2001": 0.05694137513637543, "2007": 0.3423145115375519, "2028": 0.37304413318634033, "2029": 0.0019512200960889459, "2033": 0.35813871026039124, "2034": 0.08513788133859634,... | 3471191 | IMPORTANCE The programmed death 1 (PD-1) pathway limits immune responses to melanoma and can be blocked with the humanized anti-PD-1 monoclonal antibody pembrolizumab. OBJECTIVE To characterize the association of pembrolizumab with tumor response and overall survival among patients with advanced melanoma. DESIGN, SETTI... | Association of Pembrolizumab With Tumor Response and Survival Among Patients With Advanced Melanoma. |
{"2003": 0.08603433519601822, "2007": 0.05046287178993225, "2011": 0.0029254043474793434, "2013": 0.10555581003427505, "2024": 0.255429208278656, "2076": 0.11256109178066254, "2079": 0.07250232994556427, "2129": 0.014542185701429844, "2179": 0.25088030099868774, "2213": 0.41840189695358276, "2229": 0.23402166366577148,... | 3475317 | Granulomas are the pathological hallmark of tuberculosis (TB). However, their function and mechanisms of formation remain poorly understood. To understand the role of granulomas in TB, we analyzed the proteomes of granulomas from subjects with tuberculosis in an unbiased manner. Using laser-capture microdissection, mas... | Inflammatory signaling in human Tuberculosis granulomas is spatially organized |
{"1011": 0.13925230503082275, "1038": 0.08513788133859634, "1044": 0.7286425232887268, "1060": 0.6639154553413391, "2002": 0.8109301924705505, "2005": 0.3656192123889923, "2011": 0.22782009840011597, "2029": 0.21214580535888672, "2039": 0.2667117714881897, "2065": 1.27701997756958, "2071": 0.04953393340110779, "2076": ... | 3493623 | Objective Interferons (IFNs) mediate direct antiviral activity. They play a crucial role in the early host immune response against viral infections. However, IFN therapy for HBV infection is less effective than for other viral infections. Design We explored the cellular targets of HBV in response to IFNs using proteome... | Suppression of interferon-mediated anti-HBV response by single CpG methylation in the 5′-UTR of TRIM22 |
{"1038": 0.8212929964065552, "1039": 0.2674594223499298, "1041": 0.20739519596099854, "1043": 0.08064348995685577, "2003": 0.20501139760017395, "2008": 0.02792670577764511, "2011": 0.21687394380569458, "2013": 0.3077431619167328, "2015": 0.5220900774002075, "2024": 0.4831010699272156, "2037": 0.14264501631259918, "2046... | 3495456 | Summary Neutrophils are specialized innate cells that require constant replenishment from proliferative bone marrow (BM) precursors as a result of their short half‐life. Although it is established that neutrophils are derived from the granulocyte‐macrophage progenitor (GMP), the differentiation pathways from GMP to fun... | Developmental Analysis of Bone Marrow Neutrophils Reveals Populations Specialized in Expansion, Trafficking, and Effector Functions |
{"1015": 0.7028654217720032, "1046": 0.5324648022651672, "1047": 0.1889725625514984, "1050": 0.3963087201118469, "1056": 0.7305257320404053, "1059": 0.1602703034877777, "1155": 0.37102460861206055, "1156": 0.3615458607673645, "1164": 0.36494144797325134, "2002": 0.8255793452262878, "2007": 0.32270604372024536, "2008": ... | 3504761 | The MAP kinase kinase kinase TGFβ-activated kinase 1 (TAK1) is activated by TLRs, IL-1, TNF, and TGFβ and in turn activates IKK-NF-κB and JNK, which regulate cell survival, growth, tumorigenesis, and metabolism. TAK1 signaling also upregulates AMPK activity and autophagy. Here, we investigated TAK1-dependent regulation... | TAK1-mediated autophagy and fatty acid oxidation prevent hepatosteatosis and tumorigenesis. |
{"1011": 0.2026219218969345, "1016": 0.11430477350950241, "1017": 0.4437839686870575, "1996": 0.5127768516540527, "1998": 0.2969166338443756, "2012": 0.18004031479358673, "2024": 0.11778303235769272, "2029": 0.24554696679115295, "2073": 0.26296505331993103, "2076": 0.16276304423809052, "2078": 0.43434104323387146, "207... | 3506723 | The actin cytoskeleton and adhesion junctions are physically and functionally coupled at the cell-cell interface between epithelial cells. The actin regulatory complex Arp2/3 has an established role in the turnover of junctional actin; however, the role of formins, the largest group of actin regulators, is less clear. ... | Formins at the Junction. |
{"1011": 0.5404602885246277, "1053": 0.0354953333735466, "1054": 0.06337817758321762, "2003": 0.4190443754196167, "2005": 0.045809537172317505, "2006": 0.12728634476661682, "2008": 0.022212404757738113, "2011": 0.34370049834251404, "2012": 0.14349138736724854, "2013": 0.22157983481884003, "2024": 0.2184450328350067, "2... | 3512154 | CRISPR-Cas (clustered, regularly interspaced short palindromic repeats coupled with CRISPR-associated proteins) is a bacterial immunity system that protects against invading phages or plasmids. In the process of CRISPR adaptation, short pieces of DNA ('spacers') are acquired from foreign elements and integrated into th... | CRISPR adaptation biases explain preference for acquisition of foreign DNA |
{"1011": 0.06154331564903259, "1015": 0.3262358605861664, "1017": 0.11168810725212097, "1040": 0.045809537172317505, "1044": 0.43938836455345154, "1045": 0.7500885725021362, "1997": 0.007782140281051397, "1998": 0.2447827309370041, "1999": 0.1913948506116867, "2007": 0.12814582884311676, "2011": 0.18816383183002472, "2... | 3514072 | Gene expression is controlled by the complex interaction of transcription factors binding to promoters and other regulatory DNA elements. One common characteristic of the genomic regions associated with regulatory proteins is a pronounced sensitivity to DNase I digestion. We generated genome-wide high-resolution maps o... | High-resolution mapping of open chromatin in the rice genome. |
{"1014": 0.2607102394104004, "1038": 0.5244048833847046, "1059": 1.0094679594039917, "1998": 0.037378571927547455, "2001": 0.12814582884311676, "2012": 0.11517547070980072, "2034": 0.176772341132164, "2043": 0.15442965924739838, "2044": 0.41065993905067444, "2053": 0.3784096837043762, "2057": 0.33953672647476196, "2058... | 3514540 | BACKGROUND Epidemiologic studies have found that overall obesity is positively related to endometrial cancer (EC) risk. However, data assessing the association between body fat distribution and risk of EC are still limited. METHODS We followed 51,948 women who first reported waist circumference (WC) and hip circumferen... | Prospective study of body fat distribution and the risk of endometrial cancer. |
{"1014": 0.5410289764404297, "1018": 0.021256839856505394, "1021": 0.10379679501056671, "1023": 0.03266380727291107, "1042": 0.27044451236724854, "1050": 0.272677481174469, "1052": 0.5540198087692261, "1057": 0.3554046154022217, "2012": 0.20102575421333313, "2034": 0.39762192964553833, "2038": 0.0770333781838417, "2042... | 3524352 | High breast cancer mortality rates have been reported in the northeastern part of the United States, with recent attention focused on Long Island, New York. In this study, the authors investigate whether the high breast cancer mortality is evenly spread over the Northeast, in the sense that any observed clusters of dea... | Breast cancer clusters in the northeast United States: a geographic analysis. |
{"1011": 0.17759032547473907, "1038": 0.26296505331993103, "1039": 0.06886265426874161, "1050": 0.3519764244556427, "1051": 0.4734157919883728, "1056": 0.45870962738990784, "2004": 0.13670019805431366, "2011": 0.0797421783208847, "2015": 0.3850763738155365, "2026": 0.7220231294631958, "2029": 0.1677299439907074, "2031"... | 3531388 | Bone homeostasis is maintained by the balance between bone-forming osteoblasts and bone-degrading osteoclasts. Osteoblasts have a mesenchymal origin whereas osteoclasts belong to the myeloid lineage. Osteoclast and osteoblast communication occurs through soluble factors secretion, cell-bone interaction and cell-cell co... | CD200R/CD200 Inhibits Osteoclastogenesis: New Mechanism of Osteoclast Control by Mesenchymal Stem Cells in Human |
{"1009": 0.7951818704605103, "1011": 0.33325836062431335, "1015": 0.07793712615966797, "1018": 0.5827828645706177, "1020": 0.03266380727291107, "1038": 0.2667117714881897, "1039": 0.19220098853111267, "1049": 0.5827828645706177, "1056": 1.0101795196533203, "1999": 0.21765978634357452, "2005": 0.12384103983640671, "2011... | 3545805 | CD4+ T cells can differentiate into multiple effector subsets, but the potential roles of these subsets in anti-tumor immunity have not been fully explored. Seeking to study the impact of CD4+ T cell polarization on tumor rejection in a model mimicking human disease, we generated a new MHC class II-restricted, T-cell r... | Tumor-specific Th17-polarized cells eradicate large established melanoma. |
{"1013": 0.05046287178993225, "1014": 0.21293537318706512, "1018": 0.21687394380569458, "1019": 0.23710809648036957, "1020": 0.5551415085792542, "1021": 0.4574742913246155, "1022": 0.14939609169960022, "1023": 0.37907835841178894, "1026": 0.32058215141296387, "1028": 0.0354953333735466, "1044": 0.5887627601623535, "104... | 3552753 | BACKGROUND In the assessment of severity in community acquired pneumonia (CAP), the modified British Thoracic Society (mBTS) rule identifies patients with severe pneumonia but not patients who might be suitable for home management. A multicentre study was conducted to derive and validate a practical severity assessment... | Defining community acquired pneumonia severity on presentation to hospital: an international derivation and validation study. |
{"1011": 0.07159364968538284, "1016": 0.28082266449928284, "1039": 0.4624064862728119, "1052": 0.0606246218085289, "2004": 0.014542185701429844, "2005": 0.1229778528213501, "2007": 0.015504186972975731, "2029": 0.2539152204990387, "2094": 0.6343214511871338, "2119": 0.39367714524269104, "2152": 0.10379679501056671, "21... | 3553087 | Chronic obstructive pulmonary disease (COPD) is linked to both cigarette smoking and genetic determinants. We have previously identified iron-responsive element-binding protein 2 (IRP2) as an important COPD susceptibility gene and have shown that IRP2 protein is increased in the lungs of individuals with COPD. Here we ... | Mitochondrial iron chelation ameliorates cigarette-smoke induced bronchitis and emphysema in mice |
{"1015": 0.3381449282169342, "1039": 0.6603899002075195, "1999": 0.04113444685935974, "2005": 0.17020416259765625, "2007": 0.29619070887565613, "2011": 0.304147332906723, "2028": 0.0770333781838417, "2029": 0.034552380442619324, "2091": 0.42926809191703796, "2099": 0.6022219061851501, "2109": 0.3588210940361023, "2182"... | 3559136 | Tumor-associated macrophages (TAM) contribute to all aspects of tumor progression. Use of CSF1R inhibitors to target TAM is therapeutically appealing, but has had very limited anti-tumor effects. Here, we have identified the mechanism that limited the effect of CSF1R targeted therapy. We demonstrated that carcinoma-ass... | Cancer-Associated Fibroblasts Neutralize the Anti-tumor Effect of CSF1 Receptor Blockade by Inducing PMN-MDSC Infiltration of Tumors. |
{"1011": 0.10993985831737518, "1015": 0.6000806093215942, "1020": 0.26820653676986694, "1039": 0.5528968572616577, "1058": 0.17020416259765625, "1999": 0.2539152204990387, "2000": 0.020300358533859253, "2005": 0.00875066313892603, "2007": 0.07250232994556427, "2009": 0.17759032547473907, "2011": 0.2184450328350067, "20... | 3566945 | Broadly neutralizing antibodies (bnAbs) to HIV-1 can evolve after years of an iterative process of virus escape and antibody adaptation that HIV-1 vaccine design seeks to mimic. To enable this, properties that render HIV-1 envelopes (Env) capable of eliciting bnAb responses need to be defined. Here, we followed the evo... | Phenotypic deficits in the HIV-1 envelope are associated with the maturation of a V2-directed broadly neutralizing antibody lineage |
{"1011": 0.04674193635582924, "1014": 0.42353010177612305, "1050": 0.6420594453811646, "1052": 0.7674643993377686, "1054": 0.46853771805763245, "1055": 0.5795059204101562, "2026": 0.6907027959823608, "2029": 0.1477125883102417, "2061": 0.8272887468338013, "2064": 0.0913962796330452, "2084": 0.37304413318634033, "2086":... | 3572885 | Tumor-specific mutations can result in immunogenic neoantigens, both of which have been correlated with responsiveness to immune checkpoint inhibitors in highly mutagenic cancers. However, early results of single-agent checkpoint inhibitors in multiple myeloma (MM) have been underwhelming. Therefore, we sought to under... | High somatic mutation and neoantigen burden are correlated with decreased progression-free survival in multiple myeloma |
{"1052": 0.30558720231056213, "2001": 0.17759032547473907, "2015": 0.011650617234408855, "2020": 0.2478361576795578, "2034": 0.35334911942481995, "2039": 0.2637155055999756, "2043": 0.3547199070453644, "2044": 0.3877306580543518, "2047": 0.49626702070236206, "2050": 0.31132611632347107, "2051": 0.6441128253936768, "207... | 3578380 | Importance Postmarket safety events of novel pharmaceuticals and biologics occur when new safety risks are identified after initial regulatory approval of these therapeutics. These safety events can change how novel therapeutics are used in clinical practice and inform patient and clinician decision making. Objectives ... | Postmarket Safety Events Among Novel Therapeutics Approved by the US Food and Drug Administration Between 2001 and 2010 |
{"1020": 0.07250232994556427, "1043": 0.7898768186569214, "1050": 0.07250232994556427, "1051": 0.0354953333735466, "1052": 0.2470736801624298, "2011": 0.9371650815010071, "2012": 0.3526630103588104, "2022": 0.026976587250828743, "2038": 0.1905880719423294, "2052": 0.055094651877880096, "2055": 0.22704219818115234, "206... | 3580005 | BACKGROUND Chronic obstructive pulmonary disease (COPD) has a high prevalence rate in Germany and a further increase is expected within the next years. Although risk factors on an individual level are widely understood, only little is known about the spatial heterogeneity and population-based risk factors of COPD. Back... | Who is where at risk for Chronic Obstructive Pulmonary Disease? A spatial epidemiological analysis of health insurance claims for COPD in Northeastern Germany |
{"1011": 0.22782009840011597, "2000": 0.0174254160374403, "2008": 0.04207121208310127, "2011": 0.33325836062431335, "2015": 0.46853771805763245, "2024": 0.09228714555501938, "2029": 0.28155985474586487, "2034": 0.29328158497810364, "2046": 0.24018502235412598, "2075": 0.1970241367816925, "2078": 0.3923587501049042, "20... | 3583084 | The conversion of lineage-committed cells to induced pluripotent stem cells (iPSCs) by reprogramming is accompanied by a global remodeling of the epigenome, resulting in altered patterns of gene expression. Here we characterize the transcriptional reorganization of large intergenic non-coding RNAs (lincRNAs) that occur... | Large intergenic non-coding RNA-RoR modulates reprogramming of human induced pluripotent stem cells |
{"1011": 0.1011524572968483, "1016": 0.010684899985790253, "1041": 0.4654768109321594, "1055": 0.02316705882549286, "1996": 0.04860413447022438, "1997": 0.08692999184131622, "1999": 0.06246116757392883, "2015": 0.7836518287658691, "2024": 0.2622140049934387, "2029": 0.255429208278656, "2048": 0.6769026517868042, "2079"... | 3588621 | Two broad categories of extracellular vesicles (EVs), exosomes and shed microvesicles (sMVs), which differ in size distribution as well as protein and RNA profiles, have been described. EVs are known to play key roles in cell-cell communication, acting proximally as well as systemically. This Review discusses the natur... | Extracellular vesicle isolation and characterization: toward clinical application. |
{"1011": 0.12986256182193756, "1016": 0.2026219218969345, "1038": 0.3012613356113434, "1044": 0.22548456490039825, "1045": 0.17020416259765625, "1050": 0.11517547070980072, "1053": 0.07159364968538284, "1059": 0.9092346429824829, "1156": 0.10731173306703568, "2007": 0.05417001247406006, "2011": 0.08782484382390976, "20... | 3590806 | BACKGROUND Colorectal cancer remains one of the most common malignant tumors worldwide. Colorectal cancer initiating cells (CCICs) are a small subpopulation responsible for malignant behaviors of colorectal cancer. Aberrant activation of the Wnt pathways regulates the self-renewal of CCIC. However, the underlying mecha... | Up-regulated NRIP2 in colorectal cancer initiating cells modulates the Wnt pathway by targeting RORβ |
{"1011": 0.12986256182193756, "1996": 0.49030399322509766, "1998": 0.16276304423809052, "2000": 0.1873544454574585, "2007": 0.0354953333735466, "2011": 0.3141832649707794, "2012": 0.4412745535373688, "2013": 0.5133614540100098, "2029": 0.2447827309370041, "2041": 0.10731173306703568, "2046": 0.175953671336174, "2064": ... | 3591070 | Sterol transport between the endoplasmic reticulum (ER) and plasma membrane (PM) occurs by nonvesicular mechanisms requiring sterol transport proteins (STPs). Here we examine the idea that transport is enhanced at membrane contact sites where the ER is closely apposed to the PM. We conclude that sterol desorption from ... | Speed Limits for Nonvesicular Intracellular Sterol Transport. |
{"1043": 0.21372433006763458, "1050": 0.0038986403960734606, "1056": 0.012615402229130268, "1997": 0.2034190446138382, "1998": 0.31132611632347107, "2000": 0.0354953333735466, "2007": 0.05046287178993225, "2012": 0.22626367211341858, "2015": 0.32553088665008545, "2020": 0.04860413447022438, "2025": 0.37035053968429565,... | 3610080 | OBJECTIVES To identify and describe misunderstandings between patients and doctors associated with prescribing decisions in general practice. DESIGN Qualitative study. SETTING 20 general practices in the West Midlands and south east England. PARTICIPANTS 20 general practitioners and 35 consulting patients. MAIN OUTCOME... | Misunderstandings in prescribing decisions in general practice: qualitative study. |
{"1011": 0.5290185213088989, "1015": 0.8731874823570251, "1016": 0.36967599391937256, "1038": 0.9425065517425537, "1043": 1.1702059507369995, "1052": 0.4950772523880005, "1155": 0.10291612148284912, "2003": 0.2184450328350067, "2005": 0.29619070887565613, "2015": 0.42225050926208496, "2028": 0.42353010177612305, "2029"... | 3610282 | The class B glucagon-like peptide-1 (GLP-1) G protein-coupled receptor is a major target for the treatment of type 2 diabetes and obesity. Endogenous and mimetic GLP-1 peptides exhibit biased agonism—a difference in functional selectivity—that may provide improved therapeutic outcomes. Here we describe the structure of... | Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor–Gs complex |
{"1014": 0.06429435312747955, "1018": 0.10818854719400406, "1019": 0.3870677351951599, "1020": 0.1970241367816925, "1021": 0.026025565341114998, "1022": 0.21530038118362427, "1023": 0.23556606471538544, "1038": 0.8004589080810547, "1045": 0.17840765416622162, "1050": 0.5833279490470886, "1051": 0.3141832649707794, "200... | 3613041 | Dosing convenience is a key element in the effective management of any chronic disease, and is particularly important in the long-term management of osteoporosis. Less frequent dosing with any medication may enhance compliance, thereby maximizing the effectiveness of therapy. Animal data support the rationale that once... | Therapeutic equivalence of alendronate 70 mg once-weekly and alendronate 10 mg daily in the treatment of osteoporosis. Alendronate Once-Weekly Study Group. |
{"1009": 0.4679262638092041, "1011": 0.4500300884246826, "1014": 0.31560876965522766, "1018": 0.7276995778083801, "1052": 0.15275461971759796, "1054": 0.417115718126297, "1056": 0.9754437208175659, "2006": 0.2689530849456787, "2007": 0.2667117714881897, "2012": 0.4818955361843109, "2029": 0.3374483287334442, "2039": 0.... | 3616843 | BACKGROUND Although Toll-like receptor 4 (TLR-4) is involved in monocyte activation in patients with accelerated forms of atherosclerosis, the relationship between the expression of TLR-4 on circulating monocytes and coronary plaque vulnerability has not previously been evaluated. We investigated this relationship usin... | Association of Toll-Like Receptor 4 on Human Monocyte Subsets and Vulnerability Characteristics of Coronary Plaque as Assessed by 64-Slice Multidetector Computed Tomography. |
{"1011": 0.007782140281051397, "1039": 0.0058422754518687725, "1041": 0.13499516248703003, "1082": 0.05417001247406006, "1999": 0.09406650811433792, "2000": 0.05417001247406006, "2005": 0.32199856638908386, "2015": 0.5180262327194214, "2024": 0.1064341589808464, "2026": 0.4855078160762787, "2043": 0.1913948506116867, "... | 3619372 | Stem cell-based approaches to cardiac regeneration are increasingly viable strategies for treating heart failure. Generating abundant and functional autologous cells for transplantation in such a setting, however, remains a significant challenge. Here, we isolated a cell population with extensive proliferation capacity... | Expandable Cardiovascular Progenitor Cells Reprogrammed from Fibroblasts. |
{"1038": 0.6573580503463745, "1056": 0.20022670924663544, "1156": 0.12986256182193756, "2005": 0.31132611632347107, "2008": 0.03831886500120163, "2012": 0.3683255612850189, "2025": 0.00875066313892603, "2029": 0.1677299439907074, "2044": 0.05417001247406006, "2049": 0.058784693479537964, "2050": 0.14179791510105133, "2... | 3619931 | Thyroid hormone (TH) is critical for the maintenance of cellular homeostasis during stress responses, but its role in lung fibrosis is unknown. Here we found that the activity and expression of iodothyronine deiodinase 2 (DIO2), an enzyme that activates TH, were higher in lungs from patients with idiopathic pulmonary f... | Thyroid hormone inhibits lung fibrosis in mice by improving epithelial mitochondrial function |
{"1016": 0.2659635543823242, "1038": 0.36697331070899963, "1041": 0.7692760229110718, "1056": 0.1619328260421753, "1059": 0.04487626627087593, "1999": 0.1212492436170578, "2004": 0.13071982562541962, "2005": 0.08871890604496002, "2012": 0.026025565341114998, "2029": 0.20580662786960602, "2039": 0.6664261221885681, "205... | 3621011 | Proper regulation of energy storage in adipose tissue is crucial for maintaining insulin sensitivity and molecules contributing to this process have not been fully revealed. Here we show that type II transmembrane protein tenomodulin (TNMD) is upregulated in adipose tissue of insulin-resistant versus insulin-sensitive ... | Tenomodulin promotes human adipocyte differentiation and beneficial visceral adipose tissue expansion. |
{"1997": 0.043007105588912964, "2001": 0.06703783571720123, "2011": 0.21293537318706512, "2012": 0.319873183965683, "2020": 0.10203468054533005, "2025": 0.14349138736724854, "2031": 0.14939609169960022, "2038": 0.44753631949424744, "2039": 0.1510767638683319, "2042": 0.304147332906723, "2043": 0.2881702482700348, "2044... | 3623127 | Driven by technological progress, human life expectancy has increased greatly since the nineteenth century. Demographic evidence has revealed an ongoing reduction in old-age mortality and a rise of the maximum age at death, which may gradually extend human longevity. Together with observations that lifespan in various ... | Evidence for a limit to human lifespan |
{"1011": 0.1693800985813141, "1014": 0.11256109178066254, "1015": 0.4950772523880005, "1016": 0.637939989566803, "1018": 0.040196798741817474, "1019": 0.28597161173820496, "1020": 0.16276304423809052, "1022": 0.27934664487838745, "1038": 0.14349138736724854, "1043": 0.7898768186569214, "1044": 0.3519764244556427, "1050... | 3654468 | Importance Glucagon-like peptide-1 (GLP-1) receptor agonists are effective therapies for the treatment of type 2 diabetes and are all currently available as an injection. Objectives To compare the effects of oral semaglutide with placebo (primary) and open-label subcutaneous semaglutide (secondary) on glycemic control ... | Effect of Oral Semaglutide Compared With Placebo and Subcutaneous Semaglutide on Glycemic Control in Patients With Type 2 Diabetes: A Randomized Clinical Trial |
{"1011": 0.04487626627087593, "1012": 0.09672962874174118, "1038": 1.0271050930023193, "1049": 0.43244171142578125, "2000": 0.06612417846918106, "2003": 0.055094651877880096, "2005": 0.07793712615966797, "2007": 0.17020416259765625, "2011": 0.10467668622732162, "2029": 0.1710275560617447, "2034": 0.4932899475097656, "2... | 3662132 | MOTIVATION The enormous amount of short reads generated by the new DNA sequencing technologies call for the development of fast and accurate read alignment programs. A first generation of hash table-based methods has been developed, including MAQ, which is accurate, feature rich and fast enough to align short reads fro... | Fast and accurate short read alignment with Burrows–Wheeler transform |
{"1023": 0.3084607720375061, "1069": 0.05970508232712746, "1997": 0.07250232994556427, "2000": 0.2409527748823166, "2013": 0.30989447236061096, "2033": 0.1677299439907074, "2062": 0.08961215615272522, "2073": 0.2184450328350067, "2082": 0.6265231370925903, "2085": 0.23402166366577148, "2088": 0.19622190296649933, "2098... | 3662510 | OBJECTIVE To estimate the lost investment of domestically educated doctors migrating from sub-Saharan African countries to Australia, Canada, the United Kingdom, and the United States. DESIGN Human capital cost analysis using publicly accessible data. SETTINGS Sub-Saharan African countries. PARTICIPANTS Nine sub-Sahara... | The financial cost of doctors emigrating from sub-Saharan Africa: human capital analysis |
{"1011": 0.10467668622732162, "1021": 0.12470348179340363, "1039": 0.36426326632499695, "1041": 0.4349733293056488, "1044": 0.2659635543823242, "1047": 0.6634125709533691, "1061": 0.8731874823570251, "2004": 0.05786345899105072, "2007": 0.02887592278420925, "2010": 0.8805016279220581, "2011": 0.4974553883075714, "2015"... | 3669694 | Generation of induced pluripotent stem cells (iPSCs) by somatic cell reprogramming involves global epigenetic remodelling. Whereas several proteins are known to regulate chromatin marks associated with the distinct epigenetic states of cells before and after reprogramming, the role of specific chromatin-modifying enzym... | Chromatin modifying enzymes as modulators of reprogramming |
{"1998": 0.3560888469219208, "2006": 0.026025565341114998, "2011": 0.21530038118362427, "2020": 0.04953393340110779, "2071": 0.022212404757738113, "2075": 0.10203468054533005, "2106": 0.12384103983640671, "2111": 0.23556606471538544, "2179": 0.2501201331615448, "2188": 0.6492279767990112, "2287": 0.3864043951034546, "2... | 3672261 | The quantification and characterization of circulating immune cells provide key indicators of human health and disease. To identify the relative effects of environmental and genetic factors on variation in the parameters of innate and adaptive immune cells in homeostatic conditions, we combined standardized flow cytome... | Natural variation in the parameters of innate immune cells is preferentially driven by genetic factors |
{"1041": 0.5393219590187073, "1045": 0.7436100244522095, "2003": 0.21135559678077698, "2008": 0.07159364968538284, "2011": 0.3318578004837036, "2024": 0.4400174915790558, "2029": 0.030771657824516296, "2037": 0.022212404757738113, "2054": 0.23247487843036652, "2079": 0.27712854743003845, "2207": 0.20977331697940826, "2... | 3680979 | Mast cells are unique tissue-resident immune cells that express an array of receptors that can be activated by several extracellular cues, including antigen-immunoglobulin E (IgE) complexes, bacteria, viruses, cytokines, hormones, peptides, and drugs. Mast cells constitute a small population in tissues, but their extra... | The transcriptional program, functional heterogeneity, and clinical targeting of mast cells |
{"1011": 0.35677260160446167, "1021": 0.11691460013389587, "1038": 0.18654440343379974, "1039": 0.011650617234408855, "1047": 0.57457035779953, "2003": 0.42735910415649414, "2005": 0.1873544454574585, "2008": 0.09050461649894714, "2011": 0.10555581003427505, "2026": 0.31560876965522766, "2029": 0.22548456490039825, "20... | 3684342 | LIN28B is a RNA-binding protein regulating predominantly let-7 microRNAs with essential functions in inflammation, wound healing, embryonic stem cells, and cancer. LIN28B expression is associated with tumor initiation, progression, resistance, and poor outcome in several solid cancers, including lung cancer. However, t... | LIN28B enhanced tumorigenesis in an autochthonous KRASG12V-driven lung carcinoma mouse model |
{"1053": 0.7463917136192322, "2000": 0.07431721687316895, "2005": 0.3283478021621704, "2015": 0.21765978634357452, "2033": 0.6709295511245728, "2044": 0.0038986403960734606, "2048": 0.04207121208310127, "2050": 0.3070250153541565, "2086": 0.004870930220931768, "2094": 0.857568621635437, "2102": 0.26820653676986694, "21... | 3690068 | The standard treatment of partial-thickness burns includes topical silver products such as silver sulfadiazine (SSD) cream and enclosed dressings including silver-impregnated foam (Mepilex Ag; Molnlycke Health Care, Gothenburg, Sweden) and silver-laden sheets (Aquacel Ag; ConvaTec, Skillman, NJ). The current state of h... | Cost-effectiveness comparison between topical silver sulfadiazine and enclosed silver dressing for partial-thickness burn treatment. |
{"1019": 0.0797421783208847, "1050": 0.43623676896095276, "1054": 0.7934166193008423, "2000": 0.02887592278420925, "2005": 0.42353010177612305, "2006": 0.07884006202220917, "2007": 0.14602625370025635, "2029": 0.020300358533859253, "2044": 0.17840765416622162, "2050": 0.6882523894309998, "2051": 0.34370049834251404, "2... | 3692112 | This prospective, randomized study compared protocols of care using either AQUACEL Ag Hydrofiber (ConvaTec, a Bristol-Myers Squibb company, Skillman, NJ) dressing with silver (n = 42) or silver sulfadiazine (n = 42) for up to 21 days in the management of partial-thickness burns covering 5% to 40% body surface area (BSA... | Randomized clinical study of Hydrofiber dressing with silver or silver sulfadiazine in the management of partial-thickness burns. |
{"1039": 0.09672962874174118, "1044": 0.4932899475097656, "1058": 0.04394211992621422, "2000": 0.16276304423809052, "2001": 0.18167030811309814, "2002": 0.6435998678207397, "2004": 0.0752234235405922, "2005": 0.0606246218085289, "2011": 0.4531385898590088, "2031": 0.0019512200960889459, "2038": 0.23092569410800934, "20... | 3698758 | The risk of HCV transmission by blood and blood products has been greatly reduced since the early 1980's. Selection of non-remunerated donors, donor selection to prevent HIV transmission, initial surrogate testing in some regions, and introduction of anti-HCV testing have all contributed to this. ALT surrogate testing ... | Hepatitis C virus and blood transfusion: past and present risks. |
{"1020": 0.3949938118457794, "1040": 1.0298984050750732, "1044": 0.2763880789279938, "1048": 0.040196798741817474, "1052": 0.6170841455459595, "1054": 0.5186077356338501, "1058": 0.7229714393615723, "1999": 0.05139094591140747, "2002": 1.018678069114685, "2005": 0.10906458646059036, "2007": 0.2026219218969345, "2008": ... | 3701541 | Hepatic stellate cells (HSCs) play critical roles in liver fibrosis and hepatocellular carcinoma (HCC). Vitamin D receptor (VDR) activation in HSCs inhibits liver inflammation and fibrosis. We found that p62/SQSTM1, a protein upregulated in liver parenchymal cells but downregulated in HCC-associated HSCs, negatively co... | p62/SQSTM1 by Binding to Vitamin D Receptor Inhibits Hepatic Stellate Cell Activity, Fibrosis, and Liver Cancer. |
{"2000": 0.255429208278656, "2003": 0.23864774405956268, "2005": 0.11604541540145874, "2008": 0.016465263441205025, "2024": 0.14433705806732178, "2045": 0.19622190296649933, "2047": 0.04860413447022438, "2051": 0.06429435312747955, "2052": 0.2409527748823166, "2057": 0.06795065850019455, "2064": 0.006812678650021553, "... | 3707035 | In the coming decades, a massive shift in the aging segment of the population will have major social and economic consequences around the world. One way to offset this increase is to expedite the development of geroprotectors, substances that slow aging, repair age-associated damage and extend healthy lifespan, or heal... | Developing criteria for evaluation of geroprotectors as a key stage toward translation to the clinic |
{"1011": 0.5844172835350037, "1015": 0.2394166737794876, "1038": 0.31132611632347107, "1039": 0.009718249551951885, "1056": 0.1946154683828354, "1059": 0.7881022095680237, "1060": 0.4770587682723999, "1062": 0.41840189695358276, "1155": 0.06977381557226181, "1156": 1.3464484214782715, "2002": 0.8169882297515869, "2003"... | 3710557 | β-catenin (encoded by CTNNB1) is a subunit of the cell surface cadherin protein complex that acts as an intracellular signal transducer in the WNT signaling pathway; alterations in its activity have been associated with the development of hepatocellular carcinoma and other liver diseases. Other than WNT, additional sig... | β-Catenin Signaling and Roles in Liver Homeostasis, Injury, and Tumorigenesis. |
{"1062": 0.13157635927200317, "1997": 0.12038381397724152, "2001": 0.15943801403045654, "2012": 0.04207121208310127, "2042": 0.12642613053321838, "2043": 0.306306391954422, "2057": 0.06703783571720123, "2084": 0.2409527748823166, "2086": 0.5871354341506958, "2087": 0.24325250089168549, "2088": 0.5278670787811279, "2095... | 3716075 | BACKGROUND Dengue is the most common arbovirus infection globally, but its burden is poorly quantified. We estimated dengue mortality, incidence, and burden for the Global Burden of Disease Study 2013. METHODS We modelled mortality from vital registration, verbal autopsy, and surveillance data using the Cause of Death ... | The global burden of dengue: an analysis from the Global Burden of Disease Study 2013. |
{"1011": 0.45251765847206116, "1015": 0.06977381557226181, "1017": 0.2478361576795578, "1040": 0.03925827145576477, "1041": 0.7934166193008423, "1042": 0.7276995778083801, "2003": 0.0029254043474793434, "2004": 0.0354953333735466, "2005": 0.3325583338737488, "2012": 0.4568560719490051, "2029": 0.21922965347766876, "204... | 3720107 | Cadherin-mediated cell-cell adhesion is required for epithelial tissue integrity in homeostasis, during development, and in tissue repair. E-cadherin stability depends on F-actin, but the mechanisms regulating actin polymerization at cell-cell junctions remain poorly understood. Here we investigated a role for formin-m... | Formin-mediated actin polymerization at cell–cell junctions stabilizes E-cadherin and maintains monolayer integrity during wound repair |
{"1011": 0.16607704758644104, "1041": 0.4512746334075928, "1050": 0.5816917419433594, "1155": 0.22392450273036957, "1156": 0.45870962738990784, "1996": 0.06246116757392883, "2011": 0.2749055027961731, "2012": 0.2493593990802765, "2015": 0.9013357162475586, "2029": 0.17840765416622162, "2076": 0.09050461649894714, "2078... | 3727986 | Cancer-associated fibroblasts (CAFs) promote tumour invasion and metastasis. We show that CAFs exert a physical force on cancer cells that enables their collective invasion. Force transmission is mediated by a heterophilic adhesion involving N-cadherin at the CAF membrane and E-cadherin at the cancer cell membrane. Thi... | A mechanically active heterotypic E-cadherin/N-cadherin adhesion enables fibroblasts to drive cancer cell invasion |
{"1011": 0.27934664487838745, "1048": 0.8039615154266357, "2004": 0.05139094591140747, "2005": 0.09228714555501938, "2006": 0.26446542143821716, "2007": 0.07431721687316895, "2008": 0.0842406153678894, "2011": 0.26820653676986694, "2015": 0.14433705806732178, "2029": 0.2763880789279938, "2033": 0.2105647772550583, "204... | 3730196 | Despite progress in treatment of small cell lung cancer (SCLC), its multidrug chemoresistance and poor prognosis still remain. Recently, we globally assessed long non-coding RNAs (lncRNAs) for contributions to SCLC chemoresistance using microarray data, in vitro and in vivo assays. Here we reported that HOTTIP, encodin... | Long non-coding RNA HOTTIP promotes BCL-2 expression and induces chemoresistance in small cell lung cancer by sponging miR-216a |
{"1012": 0.16359257698059082, "1014": 0.5618454217910767, "1030": 0.15526613593101501, "1043": 0.7426811456680298, "1052": 0.7701805830001831, "2000": 0.08871890604496002, "2001": 0.10818854719400406, "2003": 0.06886265426874161, "2005": 0.013579257763922215, "2034": 0.13157635927200317, "2042": 0.0029254043474793434, ... | 3743071 | UNLABELLED : Visualizing genes' structure and annotated features helps biologists to investigate their function and evolution intuitively. The Gene Structure Display Server (GSDS) has been widely used by more than 60 000 users since its first publication in 2007. Here, we reported the upgraded GSDS 2.0 with a newly des... | GSDS 2.0: an upgraded gene feature visualization server |
{"1011": 0.41065993905067444, "1017": 0.2478361576795578, "1038": 0.8957691192626953, "1047": 0.7047978043556213, "1052": 0.8666408061981201, "1999": 0.02887592278420925, "2007": 0.083342544734478, "2011": 0.1221139207482338, "2029": 0.3615458607673645, "2050": 0.3084607720375061, "2076": 0.15023678541183472, "2077": 0... | 3748310 | Although the essential role of the adaptor protein SLP-65 in pre-B cell differentiation is established, the molecular mechanism underlying its function is poorly understood. In this study, we uncover a link between SLP-65–dependent signaling and the phosphoinositide-3-OH kinase (PI(3)K)–protein kinase B (PKB)–Foxo path... | SLP-65 regulates immunoglobulin light chain gene recombination through the PI(3)K-PKB-Foxo pathway |
{"1046": 0.2034190446138382, "1048": 0.7872136831283569, "1054": 0.6405166387557983, "1997": 0.151916041970253, "2015": 0.5261374711990356, "2035": 0.25088030099868774, "2041": 0.24248650670051575, "2054": 0.025073638185858727, "2062": 0.02792670577764511, "2073": 0.21922965347766876, "2080": 0.5662899017333984, "2106"... | 3752408 | BACKGROUND The Italian National Health Service (NHS) provides universal coverage to all citizens, granting primary and hospital care with a copayment system for outpatient and drug services. Financing of Local Health Trusts (LHTs) is based on a capitation system adjusted only for age, gender and area of residence. We a... | A case-mix classification system for explaining healthcare costs using administrative data in Italy. |
{"1009": 0.7342816591262817, "1011": 0.05694137513637543, "1016": 0.0606246218085289, "1038": 0.8748174905776978, "1039": 0.562402069568634, "1043": 0.6107416749000549, "1044": 0.854249119758606, "1053": 0.49030399322509766, "1059": 0.6892333030700684, "1060": 0.6624060273170471, "1999": 0.07341018319129944, "2002": 1.... | 3756384 | BACKGROUND & AIMS Hepatocytes in which the hepatitis B virus (HBV) is replicating exhibit loss of the chromatin modifying polycomb repressive complex 2 (PRC2), resulting in re-expression of specific, cellular PRC2-repressed genes. Epithelial cell adhesion molecule (EpCAM) is a PRC2-repressed gene, normally expressed in... | EpCAM-regulated intramembrane proteolysis induces a cancer stem cell-like gene signature in hepatitis B virus-infected hepatocytes. |
{"1015": 0.3034266233444214, "1038": 0.9115922451019287, "1052": 0.2659635543823242, "1999": 0.056018441915512085, "2005": 0.15023678541183472, "2011": 0.21372433006763458, "2028": 0.010684899985790253, "2029": 0.27712854743003845, "2033": 0.6833335757255554, "2063": 0.21293537318706512, "2079": 0.17020416259765625, "2... | 3758260 | Intermittent PTH administration builds bone mass and prevents fractures, but its mechanism of action is unclear. We genetically deleted the PTH/PTHrP receptor (PTH1R) in mesenchymal stem cells using Prx1Cre and found low bone formation, increased bone resorption, and high bone marrow adipose tissue (BMAT). Bone marrow ... | Parathyroid Hormone Directs Bone Marrow Mesenchymal Cell Fate. |
{"1014": 0.3547199070453644, "1020": 0.03925827145576477, "1026": 0.055094651877880096, "1044": 0.08603433519601822, "1049": 0.13670019805431366, "1050": 0.14518201351165771, "1052": 0.25845035910606384, "1056": 0.5180262327194214, "1155": 0.05139094591140747, "1164": 0.24325250089168549, "1999": 0.10818854719400406, "... | 3761017 | BACKGROUND Metformin, a widely used hypoglycemic drug, reduces stroke incidence and alleviates chronic inflammation in clinical trials. However, the effect of metformin in ischemic stroke is unclear. Here, we investigated the effect of metformin on ischemic stroke in mice and further explored the possible underlying me... | Metformin attenuates blood-brain barrier disruption in mice following middle cerebral artery occlusion |
{"1011": 0.06246116757392883, "1038": 0.6512666940689087, "1041": 1.141931176185608, "1048": 0.37102460861206055, "1058": 0.3141832649707794, "1999": 0.0038986403960734606, "2000": 0.03925827145576477, "2003": 0.17431432008743286, "2005": 0.09317722171545029, "2006": 0.40351006388664246, "2007": 0.21765978634357452, "2... | 3765739 | Resistance to apoptosis is an important component of the overall mechanism which drives the tumorigenic process. EBV is a ubiquitous human gamma-herpesvirus which preferentially establishes latent infection in viral infected B-lymphocytes. EBNA1 is typically expressed in most forms of EBV-positive malignancies and is i... | Epstein-Barr Virus nuclear antigen 1 (EBNA1) confers resistance to apoptosis in EBV-positive B-lymphoma cells through up-regulation of survivin. |
{"1015": 0.1710275560617447, "1040": 0.7800771594047546, "2003": 0.16276304423809052, "2005": 0.24325250089168549, "2047": 0.034552380442619324, "2050": 0.6430866718292236, "2051": 0.45994341373443604, "2064": 0.09406650811433792, "2079": 0.28670501708984375, "2109": 0.417115718126297, "2140": 0.19220098853111267, "216... | 3770726 | BACKGROUND Microfluidic platforms for quantitative evaluation of cell biologic processes allow low cost and time efficient research studies of biological and pathological events, such as monitoring cell migration by real-time imaging. In healthy and disease states, cell migration is crucial in development and wound hea... | Microfluidic platform to evaluate migration of cells from patients with DYT1 dystonia. |
{"1014": 0.3824150264263153, "1038": 0.5685047507286072, "1061": 0.45623743534088135, "1999": 0.043007105588912964, "2058": 0.46363574266433716, "2062": 0.1718502640724182, "2082": 0.5151132941246033, "2090": 0.2493593990802765, "2098": 0.07884006202220917, "2172": 0.03360854089260101, "2184": 0.022212404757738113, "22... | 3770750 | BACKGROUND The relation between sugar-sweetened beverages (SSBs) and body weight remains controversial. OBJECTIVE We conducted a systematic review and meta-analysis to summarize the evidence in children and adults. DESIGN We searched PubMed, EMBASE, and Cochrane databases through March 2013 for prospective cohort studi... | Sugar-sweetened beverages and weight gain in children and adults: a systematic review and meta-analysis. |
{"1039": 0.1064341589808464, "1044": 0.24248650670051575, "2003": 0.07250232994556427, "2015": 0.5827828645706177, "2024": 0.0354953333735466, "2025": 0.22937409579753876, "2031": 0.12384103983640671, "2037": 0.06154331564903259, "2038": 0.09406650811433792, "2045": 0.3683255612850189, "2057": 0.1011524572968483, "2064... | 3773719 | Human pluripotent stem cells (hPSCs) have the potential to fundamentally change the way that we go about treating and understanding human disease. Despite this extraordinary potential, these cells also have an innate capability to form tumors in immunocompromised individuals when they are introduced in their pluripoten... | The tumorigenic potential of pluripotent stem cells: What can we do to minimize it? |
{"1011": 0.06337817758321762, "1016": 0.42416930198669434, "1017": 0.7124901413917542, "1998": 0.3464667797088623, "2001": 0.09495500475168228, "2004": 0.7028654217720032, "2007": 0.11256109178066254, "2047": 0.5920094847679138, "2051": 0.28597161173820496, "2052": 0.010684899985790253, "2058": 0.2763880789279938, "206... | 3776162 | Background New sepsis and septic shock definitions could change the epidemiology of sepsis because of differences in criteria. We therefore compared the sepsis populations identified by the old and new definitions. Methods We used a high-quality, national, intensive care unit (ICU) database of 654 918 consecutive admis... | Epidemiology of sepsis and septic shock in critical care units: comparison between sepsis-2 and sepsis-3 populations using a national critical care database |
{"1011": 0.26296505331993103, "1019": 0.42926809191703796, "1022": 0.036437395960092545, "1056": 1.039613962173462, "1996": 0.09584271162748337, "1999": 0.14179791510105133, "2005": 0.009718249551951885, "2008": 0.09584271162748337, "2011": 0.5045560002326965, "2013": 0.33675122261047363, "2026": 0.8813109993934631, "2... | 3788528 | The T cell antigen-specific repertoire is thought to be shaped by thymic expression of self molecules. Since a myelin basic protein (MBP)-like gene (golli-MBP) has been reported to be expressed by cells of the immune system, the present study was undertaken to determine whether the golli-MBP gene was expressed in the m... | Thymic expression of the golli-myelin basic protein gene in the SJL/J mouse |
{"1014": 0.4158279001712799, "2004": 0.11517547070980072, "2005": 0.030771657824516296, "2007": 0.012615402229130268, "2029": 0.10731173306703568, "2050": 0.7692760229110718, "2109": 0.4412745535373688, "2116": 0.15442965924739838, "2179": 0.0019512200960889459, "2181": 0.0009760859538801014, "2193": 0.0106848999857902... | 3790895 | BACKGROUND The diagnostic value of microRNA (miRNA) detection in patients with bladder cancer (BCa) is controversial. We performed a diagnostic meta-analysis to evaluate current evidence on the use of miRNA assays to diagnose BCa. METHODS We systematically searched PubMed, Embase, and Web of Science for studies publish... | Urine microRNAs as biomarkers for bladder cancer: a diagnostic meta-analysis |
{"1011": 0.3325583338737488, "1015": 0.4909018874168396, "1043": 0.1873544454574585, "1044": 0.3777405619621277, "1056": 1.154322862625122, "1156": 1.0512858629226685, "2003": 0.11951763927936554, "2012": 0.018384648486971855, "2028": 0.17840765416622162, "2044": 0.23015019297599792, "2064": 0.026025565341114998, "2075... | 3801693 | BACKGROUND Transforming growth factor β1 (TGF-β1) is a multifunctional cytokine. There is growing evidence that TGF-β1 is involved in the pathogenesis of hypertension and the development of target organ damage in hypertensives. Although several studies have shown that TGF-β1 induced vascular hypertrophy and remodelling... | Elevated Plasma Transforming Growth Factor &bgr;1 Levels Predict the Development of Hypertension in Normotensives: The 14-Year Follow-Up Study |
{"1011": 0.22548456490039825, "1038": 0.5607312321662903, "1040": 0.09495500475168228, "1041": 0.6960725784301758, "1043": 0.25845035910606384, "1049": 0.09761575609445572, "1050": 0.567951500415802, "1996": 0.14095009863376617, "2006": 0.8442239761352539, "2008": 0.13071982562541962, "2010": 0.24325250089168549, "2011... | 3805841 | The MYC oncogene encodes MYC, a transcription factor that binds the genome through sites termed E-boxes (5'-CACGTG-3'), which are identical to the binding sites of the heterodimeric CLOCK-BMAL1 master circadian transcription factor. Hence, we hypothesized that ectopic MYC expression perturbs the clock by deregulating E... | MYC Disrupts the Circadian Clock and Metabolism in Cancer Cells. |
{"1021": 0.02316705882549286, "1039": 0.46302130818367004, "1042": 0.3005385100841522, "1053": 0.8917738795280457, "1062": 0.6734226942062378, "2006": 0.11256109178066254, "2007": 0.35813871026039124, "2013": 0.2637155055999756, "2029": 0.013579257763922215, "2048": 0.4673144817352295, "2064": 0.21765978634357452, "208... | 3823862 | BackgroundBy comparing the quail genome with that of chicken, chromosome rearrangements that have occurred in these two galliform species over 35 million years of evolution can be detected. From a more practical point of view, the definition of conserved syntenies helps to predict the position of genes in quail, based ... | Integrated maps in quail (Coturnix japonica) confirm the high degree of synteny conservation with chicken (Gallus gallus) despite 35 million years of divergence |
{"1011": 0.1994270235300064, "1040": 0.3923587501049042, "1050": 0.755608320236206, "1996": 0.1358480453491211, "2005": 0.08513788133859634, "2007": 0.12470348179340363, "2011": 0.18492233753204346, "2029": 0.20739519596099854, "2050": 0.2800849378108978, "2058": 0.5045560002326965, "2067": 0.5893046259880066, "2075": ... | 3825472 | Neural activity induces the remodeling of pre- and postsynaptic membranes, which maintain their apposition through cell adhesion molecules. Among them, N-cadherin is redistributed, undergoes activity-dependent conformational changes, and is required for synaptic plasticity. Here, we show that depolarization induces the... | Cadherin activity is required for activity-induced spine remodeling |
{"1014": 0.22079704701900482, "1016": 0.4537591338157654, "1020": 0.05417001247406006, "1026": 0.17020416259765625, "1040": 0.10203468054533005, "1044": 0.2231435477733612, "1052": 0.500420093536377, "2000": 0.1384023278951645, "2004": 0.33675122261047363, "2005": 0.11604541540145874, "2007": 0.3106105625629425, "2012"... | 3825750 | BACKGROUND Diabetic nephropathy is the leading cause of end-stage renal disease in developed countries. We evaluated the renoprotective effects of dual blockade of the renin-angiotensin-aldosterone system by adding treatment with aliskiren, an oral direct renin inhibitor, to treatment with the maximal recommended dose ... | Aliskiren combined with losartan in type 2 diabetes and nephropathy. |
{"1003": 0.11081436276435852, "1014": 0.255429208278656, "1019": 0.13157635927200317, "1038": 0.757441520690918, "1043": 0.6369074583053589, "1044": 0.35745587944984436, "1609": 0.45437926054000854, "2004": 0.04674193635582924, "2007": 0.03925827145576477, "2012": 0.31560876965522766, "2022": 0.030771657824516296, "204... | 3828508 | BACKGROUND:It is well established that a minority of celiac patients present with “classic” symptoms due to malabsorption. However, few studies have focussed on the distribution of body mass index (BMI) in celiac populations and its relationship to clinical characteristics, or on its response to treatment. METHODS:We r... | Overweight in Celiac Disease: Prevalence, Clinical Characteristics, and Effect of a Gluten-Free Diet |
{"1011": 0.22704219818115234, "1015": 0.2539152204990387, "1018": 0.5168620347976685, "1048": 0.7076893448829651, "1049": 0.14179791510105133, "1054": 0.13755162060260773, "1055": 0.17020416259765625, "1056": 0.3283478021621704, "1997": 0.10993985831737518, "2003": 0.10026945173740387, "2004": 0.0842406153678894, "2007... | 3829232 | BACKGROUND The Polycomb group (PcG) of proteins is a family of important developmental regulators. The respective members function as large protein complexes involved in establishment and maintenance of transcriptional repression of developmental control genes. MBTD1, Malignant Brain Tumor domain-containing protein 1, ... | Structural Studies of a Four-MBT Repeat Protein MBTD1 |
{"1009": 0.32270604372024536, "1040": 0.15943801403045654, "1043": 0.890972912311554, "1047": 0.272677481174469, "1052": 0.4462870955467224, "1155": 0.13755162060260773, "1997": 0.0019512200960889459, "1999": 0.15023678541183472, "2004": 0.5596157908439636, "2005": 0.18411032855510712, "2011": 0.436867892742157, "2029"... | 3831884 | Cancer cells have metabolic dependencies that distinguish them from their normal counterparts. Among these dependencies is an increased use of the amino acid glutamine to fuel anabolic processes. Indeed, the spectrum of glutamine-dependent tumours and the mechanisms whereby glutamine supports cancer metabolism remain a... | Glutamine supports pancreatic cancer growth through a Kras-regulated metabolic pathway |
{"1006": 0.026025565341114998, "1007": 0.016465263441205025, "1009": 1.0193830728530884, "1011": 0.3177432417869568, "1017": 0.10818854719400406, "1018": 0.47463157773017883, "1022": 0.35813871026039124, "1039": 0.27934664487838745, "1056": 0.997294545173645, "1157": 0.27564704418182373, "2005": 0.24325250089168549, "2... | 3835423 | Tissue-resident memory T (Trm) cells provide enhanced protection against infection at mucosal sites. Here we found that CD4(+) T cells are important for the formation of functional lung-resident CD8(+) T cells after influenza virus infection. In the absence of CD4(+) T cells, CD8(+) T cells displayed reduced expression... | CD4+ T cell help guides formation of CD103+ lung-resident memory CD8+ T cells during influenza viral infection. |
{"1009": 0.1212492436170578, "1011": 0.018384648486971855, "2005": 0.20818853378295898, "2008": 0.05139094591140747, "2029": 0.2223619967699051, "2043": 0.0174254160374403, "2046": 0.5127768516540527, "2050": 0.3262358605861664, "2052": 0.22001366317272186, "2062": 0.28155985474586487, "2064": 0.14602625370025635, "207... | 3840043 | Cell types more advanced in development than embryonic stem cells, such as EpiSCs, fail to contribute to chimeras when injected into pre-implantation-stage blastocysts, apparently because the injected cells undergo apoptosis. Here we show that transient promotion of cell survival through expression of the anti-apoptoti... | Inhibition of Apoptosis Overcomes Stage-Related Compatibility Barriers to Chimera Formation in Mouse Embryos. |
{"1011": 0.3012613356113434, "1017": 0.09495500475168228, "1021": 0.36967599391937256, "1040": 0.4450363218784332, "1052": 0.574020504951477, "1997": 0.020300358533859253, "1998": 0.02412080205976963, "2003": 0.23556606471538544, "2004": 0.04113444685935974, "2011": 0.07068414986133575, "2024": 0.3084607720375061, "202... | 3845894 | Late Embryogenesis Abundant Proteins (LEAPs) are ubiquitous proteins expected to play major roles in desiccation tolerance. Little is known about their structure - function relationships because of the scarcity of 3-D structures for LEAPs. The previous building of LEAPdb, a database dedicated to LEAPs from plants and o... | Computational and Statistical Analyses of Amino Acid Usage and Physico-Chemical Properties of the Twelve Late Embryogenesis Abundant Protein Classes |
{"1011": 0.08782484382390976, "1044": 0.4673144817352295, "1045": 0.8941729068756104, "1052": 0.4770587682723999, "1999": 0.055094651877880096, "2000": 0.07250232994556427, "2002": 1.0382318496704102, "2005": 0.3297532796859741, "2013": 0.37907835841178894, "2026": 0.8861536383628845, "2029": 0.25088030099868774, "2046... | 3847200 | Direct induction of induced hepatocytes (iHeps) from fibroblasts holds potential as a strategy for regenerative medicine but until now has only been shown in culture settings. Here, we describe in vivo iHep formation using transcription factor induction and genetic fate tracing in mouse models of chronic liver disease.... | Direct Reprogramming of Hepatic Myofibroblasts into Hepatocytes In Vivo Attenuates Liver Fibrosis. |
{"1011": 0.22937409579753876, "1015": 0.255429208278656, "1038": 0.3601844012737274, "1039": 0.4709797203540802, "1041": 0.3526630103588104, "1052": 0.4764525294303894, "1056": 0.7818660736083984, "1156": 0.7028654217720032, "1999": 0.012615402229130268, "2004": 0.5162794589996338, "2006": 0.13071982562541962, "2011": ... | 3848469 | BACKGROUND Cancer Stem Cells (CSCs) hypothesis asserts that only a small subset of cells within a tumour is capable of both tumour initiation and sustainment. The Epithelial-Mesenchymal Transition (EMT) is an embryonic developmental program that is often activated during cancer invasion and metastasis. The aim of this ... | Epithelial to Mesenchymal Transition by TGFβ-1 Induction Increases Stemness Characteristics in Primary Non Small Cell Lung Cancer Cell Line |
{"1011": 0.1734936386346817, "1017": 0.5074998140335083, "1020": 0.2763880789279938, "1038": 0.0354953333735466, "1040": 0.7500885725021362, "1044": 0.2447827309370041, "1052": 0.3519764244556427, "1998": 0.31132611632347107, "1999": 0.058784693479537964, "2005": 0.021256839856505394, "2007": 0.5244048833847046, "2008"... | 3849194 | The genome-wide localization and function of endogenous Dnmt3a and Dnmt3b in adult stem cells are unknown. Here, we show that in human epidermal stem cells, the two proteins bind in a histone H3K36me3-dependent manner to the most active enhancers and are required to produce their associated enhancer RNAs. Both proteins... | Dnmt3a and Dnmt3b Associate with Enhancers to Regulate Human Epidermal Stem Cell Homeostasis. |
{"1011": 0.1064341589808464, "1039": 0.347847044467926, "1047": 0.46486347913742065, "2005": 0.09584271162748337, "2008": 0.31560876965522766, "2024": 0.1685553640127182, "2029": 0.2478361576795578, "2034": 0.7638313174247742, "2042": 0.07341018319129944, "2045": 0.24325250089168549, "2048": 0.3034266233444214, "2064":... | 3851329 | The pursuit for drugs that inhibit cyclin-dependent kinases (CDKs) has been an intense area of research for more than 15 years. The first-generation inhibitors, Flavopiridol and CY-202, are in late-stage clinical trials, but so far have demonstrated only modest activity. Several second-generation inhibitors are now in ... | CDK inhibitors in cancer therapy: what is next? |
{"1011": 0.151916041970253, "1039": 0.4673144817352295, "1050": 0.8022117614746094, "1051": 0.5957841277122498, "1164": 0.8925741910934448, "1999": 0.04394211992621422, "2029": 0.16110190749168396, "2033": 0.5404602885246277, "2078": 0.4891071021556854, "2084": 0.10555581003427505, "2152": 0.33675122261047363, "2179": ... | 3858268 | Lack of sensitive single-cell analysis tools has limited the characterization of metabolic activity in cancer stem cells. By hyperspectral-stimulated Raman scattering imaging of single living cells and mass spectrometry analysis of extracted lipids, we report here significantly increased levels of unsaturated lipids in... | Lipid Desaturation Is a Metabolic Marker and Therapeutic Target of Ovarian Cancer Stem Cells. |
{"1011": 0.20421554148197174, "1048": 0.27934664487838745, "1049": 0.4145384132862091, "1052": 0.3588210940361023, "1056": 0.29255300760269165, "2004": 0.011650617234408855, "2015": 0.440646231174469, "2026": 0.6603899002075195, "2029": 0.037378571927547455, "2033": 1.0815403461456299, "2079": 0.02316705882549286, "208... | 3863543 | Mesenchymal niche cells may drive tissue failure and malignant transformation in the hematopoietic system, but the underlying molecular mechanisms and relevance to human disease remain poorly defined. Here, we show that perturbation of mesenchymal cells in a mouse model of the pre-leukemic disorder Shwachman-Diamond sy... | Mesenchymal Inflammation Drives Genotoxic Stress in Hematopoietic Stem Cells and Predicts Disease Evolution in Human Pre-leukemia. |
{"1011": 0.022212404757738113, "1016": 0.37707099318504333, "1017": 0.19220098853111267, "1019": 0.20660123229026794, "1048": 0.812664806842804, "1179": 0.5936289429664612, "1999": 0.1221139207482338, "2002": 0.7683706283569336, "2004": 1.0478670597076416, "2005": 0.29255300760269165, "2007": 0.16110190749168396, "2011... | 3866315 | Aspirin therapy inhibits prostaglandin biosynthesis without directly acting on lipoxygenases, yet via acetylation of cyclooxygenase 2 (COX-2) it leads to bioactive lipoxins (LXs) epimeric at carbon 15 (15-epi-LX, also termed aspirin-triggered LX [ATL]). Here, we report that inflammatory exudates from mice treated with ... | Novel Functional Sets of Lipid-Derived Mediators with Antiinflammatory Actions Generated from Omega-3 Fatty Acids via Cyclooxygenase 2–Nonsteroidal Antiinflammatory Drugs and Transcellular Processing |
{"1011": 0.13499516248703003, "1020": 0.3027053773403168, "1022": 0.5773153901100159, "1023": 0.49923527240753174, "1028": 0.022212404757738113, "1039": 0.23556606471538544, "1052": 0.5756692886352539, "1056": 0.3170322775840759, "1158": 0.35403475165367126, "1999": 0.1693800985813141, "2002": 0.10906458646059036, "200... | 3868322 | Polymorphisms in and around the Cholesteryl Ester Transfer Protein (CETP) gene have been associated with HDL levels, risk for coronary artery disease (CAD), and response to therapy. The mechanism of action of these polymorphisms has yet to be defined. We used mRNA allelic expression and splice isoform measurements in h... | Cholesteryl Ester Transfer Protein (CETP) Polymorphisms Affect mRNA Splicing, HDL Levels, and Sex-Dependent Cardiovascular Risk |
{"1011": 0.29619070887565613, "1020": 0.9613537192344666, "1039": 0.7528522610664368, "1043": 0.6563454270362854, "1052": 0.5712664127349854, "1059": 0.9348671436309814, "1999": 0.15526613593101501, "2005": 0.17267228662967682, "2011": 0.32270604372024536, "2015": 0.28963330388069153, "2029": 0.3423145115375519, "2039"... | 3870062 | Chondroitin sulphate proteoglycans (CSPGs) upregulated in the glial scar inhibit axon regeneration via their sulphated glycosaminoglycans (GAGs). Chondroitin 6-sulphotransferase-1 (C6ST-1) is upregulated after injury leading to an increase in 6-sulphated GAG. In this study, we ask if this increase in 6-sulphated GAG is... | 6-Sulphated Chondroitins Have a Positive Influence on Axonal Regeneration |
{"1011": 0.22001366317272186, "1017": 0.09050461649894714, "1041": 0.1485546976327896, "1043": 0.23556606471538544, "1044": 0.04674193635582924, "1052": 0.3134697377681732, "1057": 0.4425300657749176, "1059": 0.2659635543823242, "1156": 0.7153595685958862, "1998": 0.06612417846918106, "2002": 1.1115491390228271, "2003"... | 3874000 | Regenerative medicine is predicated on understanding the mechanisms regulating development and applying these conditions to direct stem cell fate. Embryogenesis is guided by cell-cell and cell-matrix interactions, but it is unclear how these physical cues influence stem cells in culture. We used human embryonic stem ce... | Tissue Mechanics Orchestrate Wnt-Dependent Human Embryonic Stem Cell Differentiation. |
{"1011": 0.23402166366577148, "1014": 0.3464667797088623, "1017": 0.7028654217720032, "1042": 0.7746911644935608, "1053": 1.0285027027130127, "2001": 0.06612417846918106, "2005": 0.11691460013389587, "2015": 0.32764431834220886, "2029": 0.0029254043474793434, "2050": 0.2394166737794876, "2051": 0.0770333781838417, "206... | 3878434 | In Sepsis-3, the quick Sequential Organ Failure Assessment (qSOFA) score was developed as criteria to use for recognizing patients who may have poor outcomes. This study was performed to evaluate the predictive performance of the qSOFA score as a screening tool for sepsis, mortality, and intensive care unit (ICU) admis... | Predictive performance of the quick Sequential Organ Failure Assessment score as a screening tool for sepsis, mortality, and intensive care unit admission in patients with febrile neutropenia |
{"1011": 0.3012613356113434, "1038": 0.036437395960092545, "1998": 0.21530038118362427, "1999": 0.15526613593101501, "2005": 0.3027053773403168, "2007": 0.43875885009765625, "2008": 0.15860503911972046, "2010": 0.75193190574646, "2029": 0.5833279490470886, "2050": 0.5381823778152466, "2064": 0.1751343309879303, "2076":... | 3882374 | The RNA-binding proteins LIN28A and LIN28B play critical roles in embryonic development, tumorigenesis, and pluripotency, but their exact functions are poorly understood. Here, we show that, like LIN28A, LIN28B can function effectively with NANOG, OCT4, and SOX2 in reprogramming to pluripotency and that reactivation of... | LIN28 Regulates Stem Cell Metabolism and Conversion to Primed Pluripotency. |
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