spalde-v3-lexical stringlengths 4.95k 41.3k | _id stringlengths 4 9 | text stringlengths 174 10k | title stringlengths 2 300 |
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{"1011": 0.29036402702331543, "1015": 0.5438674688339233, "1017": 0.11256109178066254, "1020": 0.34922540187835693, "1040": 0.4286321699619293, "1043": 0.613389253616333, "1057": 0.4531385898590088, "1998": 0.20977331697940826, "1999": 0.41195443272590637, "2004": 0.1332872211933136, "2007": 0.3750596046447754, "2011":... | 36386637 | We studied the effect of recombinant human interleukin-1 beta (IL-1) and recombinant human tumor necrosis factor alpha/cachectin (TNF) on glucose kinetics in healthy rats by means of a primed constant infusion of D-(6-3H)glucose and D-[U-14C]glucose. During the isotope (6-hour) and monokine (4-hour) infusion, plasma le... | Effect of interleukin-1 and tumor necrosis factor/cachectin on glucose turnover in the rat. |
{"1011": 0.10026945173740387, "1017": 0.16690383851528168, "1051": 0.02412080205976963, "1058": 0.08692999184131622, "1998": 0.03360854089260101, "2001": 0.09317722171545029, "2005": 0.10993985831737518, "2020": 0.28670501708984375, "2029": 0.07159364968538284, "2034": 0.04207121208310127, "2043": 0.1332872211933136, "... | 36398420 | The purpose of this study was to determine the lineage progression of human and murine very small embryonic-like (HuVSEL or MuVSEL) cells in vitro and in vivo. In vitro, HuVSEL and MuVSEL cells differentiated into cells of all three embryonic germ layers. HuVSEL cells produced robust mineralized tissue of human origin ... | Human and murine very small embryonic-like cells represent multipotent tissue progenitors, in vitro and in vivo. |
{"1011": 0.129004567861557, "1015": 0.34508460760116577, "1018": 0.058784693479537964, "1038": 0.07068414986133575, "1044": 0.48068851232528687, "1052": 1.0881409645080566, "2007": 0.026976587250828743, "2011": 0.43244171142578125, "2012": 0.15023678541183472, "2015": 0.35060185194015503, "2029": 0.21293537318706512, "... | 36399107 | The tumor suppressor gene p16 (CDKN2/MTS-1/INK4A) can be inactivated by multiple genetic mechanisms. We analyzed 29 invasive primary head and neck squamous cell carcinomas (HNSCC) for p16 inactivation with immunohistochemistry utilizing a new monoclonal antibody (mAb), DCS-50. p16 staining of the primary lesions was co... | High frequency of p16 (CDKN2/MTS-1/INK4A) inactivation in head and neck squamous cell carcinoma. |
{"1006": 0.16524957120418549, "1009": 0.7969439625740051, "1011": 0.15526613593101501, "1016": 0.6054253578186035, "1039": 0.16690383851528168, "1042": 0.6291293501853943, "1050": 0.5104349255561829, "1055": 0.4400174915790558, "1999": 0.040196798741817474, "2005": 0.07884006202220917, "2007": 0.33325836062431335, "200... | 36399109 | Recent studies by our group and others demonstrated a required and conserved role of Stim in store-operated Ca(2+) influx and Ca(2+) release-activated Ca(2+) (CRAC) channel activity. By using an unbiased genome-wide RNA interference screen in Drosophila S2 cells, we now identify 75 hits that strongly inhibited Ca(2+) i... | Genome-wide RNAi screen of Ca(2+) influx identifies genes that regulate Ca(2+) release-activated Ca(2+) channel activity. |
{"1999": 0.006812678650021553, "2003": 0.36290550231933594, "2004": 0.2822965085506439, "2005": 0.4531385898590088, "2011": 0.22626367211341858, "2026": 0.09761575609445572, "2029": 0.12470348179340363, "2063": 0.6338034868240356, "2064": 0.10026945173740387, "2079": 0.15023678541183472, "2080": 0.04674193635582924, "2... | 36432234 | Wedelolactone, a plant coumestan, was shown to act as anti-cancer agent for breast and prostate carcinomas in vitro and in vivo targeting multiple cellular proteins including androgen receptors, 5-lipoxygenase and topoisomerase IIα. It is cytotoxic to breast, prostate, pituitary and myeloma cancer cell lines in vitro a... | Wedelolactone induces growth of breast cancer cells by stimulation of estrogen receptor signalling. |
{"1011": 0.00875066313892603, "1020": 1.02149498462677, "1044": 0.09495500475168228, "1048": 0.6764062643051147, "1049": 0.6228629946708679, "2003": 0.083342544734478, "2011": 0.04113444685935974, "2015": 0.21135559678077698, "2024": 0.33675122261047363, "2029": 0.1221139207482338, "2042": 0.11081436276435852, "2054": ... | 36444198 | Blood monocytes are well-characterized precursors for macrophages and dendritic cells. Subsets of human monocytes with differential representation in various disease states are well known. In contrast, mouse monocyte subsets have been characterized minimally. In this study we identify three subpopulations of mouse mono... | Subpopulations of mouse blood monocytes differ in maturation stage and inflammatory response. |
{"1011": 0.1905880719423294, "1998": 0.09050461649894714, "2003": 0.34508460760116577, "2004": 0.2409527748823166, "2015": 0.2667117714881897, "2038": 0.016465263441205025, "2054": 0.10906458646059036, "2057": 0.007782140281051397, "2075": 0.2561853528022766, "2079": 0.1510767638683319, "2090": 0.08782484382390976, "21... | 36450001 | Proteogenomics has emerged as a field at the junction of genomics and proteomics. It is a loose collection of technologies that allow the search of tandem mass spectra against genomic databases to identify and characterize protein-coding genes. Proteogenomic peptides provide invaluable information for gene annotation, ... | Proteogenomics to discover the full coding content of genomes: a computational perspective. |
{"1009": 0.6950984001159668, "1011": 0.19220098853111267, "1039": 0.6960725784301758, "1047": 0.33115679025650024, "1052": 1.001607894897461, "1997": 0.14349138736724854, "1999": 0.13157635927200317, "2006": 0.23864774405956268, "2007": 0.3519764244556427, "2008": 0.1384023278951645, "2010": 0.5718178153038025, "2011":... | 36464673 | We show that, in vitro, Ca2+-dependent protein kinase C (PKC) phosphorylates recombinant murine p53 protein on several residues contained within a conserved basic region of 25 amino acids, located in the C-terminal part of the protein. Accordingly, synthetic p53-(357-381)-peptide is phosphorylated by PKC at multiple Se... | The in vitro phosphorylation of p53 by calcium-dependent protein kinase C--characterization of a protein-kinase-C-binding site on p53. |
{"1011": 0.022212404757738113, "1038": 0.28670501708984375, "1048": 0.2719337046146393, "1051": 0.9363996982574463, "1052": 0.3084607720375061, "1056": 1.0271050930023193, "1156": 0.045809537172317505, "1996": 0.15023678541183472, "2008": 0.014542185701429844, "2011": 0.4709797203540802, "2013": 0.25239890813827515, "2... | 36480032 | The ocular microenvironment is both immunosuppressive and anti-inflammatory in nature. Pigment epithelial (PE) cells isolated from the eye possess the ability to suppress the T cell receptor-dependent activation of T cells and the induction of regulatory T cells in vitro. This property is dependent on the cells’ capaci... | Role of ocular pigment epithelial cells in immune privilege |
{"1057": 0.3374483287334442, "2003": 0.025073638185858727, "2013": 0.18329764902591705, "2038": 0.11604541540145874, "2039": 0.004870930220931768, "2045": 0.0174254160374403, "2047": 0.17020416259765625, "2062": 0.010684899985790253, "2063": 0.083342544734478, "2064": 0.06520967930555344, "2095": 0.472198486328125, "21... | 36497180 | Salmonellosis poses a health problem of large proportions in the United States. Annually, it accounts for more than 40,000 reported cases, 500 deaths, and financial costs well in excess of $50 million. Antimicrobial resistance is increasing in Salmonella strains, a finding that has important public health implications.... | Drug-resistant Salmonella in the United States: an epidemiologic perspective. |
{"1006": 0.11168810725212097, "1011": 0.5313173532485962, "1015": 0.14095009863376617, "1022": 0.1873544454574585, "1039": 0.48008447885513306, "1043": 0.7134475708007812, "1050": 0.7863243818283081, "1053": 1.0172666311264038, "1997": 0.053244512528181076, "2003": 0.11168810725212097, "2008": 0.1946154683828354, "2011... | 36540079 | Deamidation of N-terminal Gln by Nt(Q)-amidase, an N-terminal amidohydrolase, is a part of the N-end rule pathway of protein degradation. We detected the activity of Nt(Q)-amidase, termed Ntaq1, in mouse tissues, purified Ntaq1 from bovine brains, identified its gene, and began analyzing this enzyme. Ntaq1 is highly co... | Glutamine-specific N-terminal amidase, a component of the N-end rule pathway. |
{"1011": 0.5197699069976807, "1015": 0.2539152204990387, "1017": 0.24401791393756866, "1020": 1.1774523258209229, "2003": 0.14349138736724854, "2005": 0.16690383851528168, "2008": 0.08513788133859634, "2010": 0.5957841277122498, "2011": 0.15860503911972046, "2012": 0.07884006202220917, "2029": 0.2160874605178833, "2057... | 36547290 | IL-6 is an immunoregulatory cytokine with multiple functions in hemopoiesis, proliferation, and tumorigenesis. IL-6 triggers phosphorylation, dimerization, and nuclear translocation of STAT3, which binds to target promoters and activates transcription. Brahma-related gene 1 (BRG1), the enzymatic engine of the yeast-mat... | Brahma-related gene 1-dependent STAT3 recruitment at IL-6-inducible genes. |
{"1003": 0.0913962796330452, "1021": 0.1477125883102417, "1022": 0.05139094591140747, "1026": 0.03266380727291107, "1038": 0.6624060273170471, "1041": 0.35060185194015503, "1043": 0.5347557663917542, "1044": 0.2711893916130066, "1998": 0.29109421372413635, "2001": 0.09228714555501938, "2004": 0.27342069149017334, "2020... | 36558211 | OBJECTIVES To explore the different characteristics of high and low fat consumers, in particular their macronutrient intake and body mass index. DESIGN Reanalysis of data from the Dietary and Nutritional Survey of British Adults. Comparisons were made between groups defined as high and low fat consumers on the basis of... | High and low fat consumers, their macronutrient intake and body mass index: further analysis of the National Diet and Nutrition Survey of British Adults. |
{"1011": 0.1510767638683319, "1012": 0.18816383183002472, "1055": 0.5063233375549316, "1996": 0.1064341589808464, "1997": 0.1358480453491211, "1999": 0.0174254160374403, "2004": 0.4818955361843109, "2011": 0.09495500475168228, "2012": 0.3916989266872406, "2029": 0.18816383183002472, "2043": 0.020300358533859253, "2051"... | 36606083 | Many fundamental aspects of DNA replication, such as the exact locations where DNA synthesis is initiated and terminated, how frequently origins are used, and how fork progression is influenced by transcription, are poorly understood. Via the deep sequencing of Okazaki fragments, we comprehensively document replication... | Quantitative, genome-wide analysis of eukaryotic replication initiation and termination. |
{"1039": 0.22079704701900482, "1044": 0.8400169610977173, "1999": 0.037378571927547455, "2005": 0.00875066313892603, "2008": 0.029824240133166313, "2012": 0.2247048318386078, "2013": 0.02792670577764511, "2029": 0.2622140049934387, "2043": 0.1693800985813141, "2044": 0.4450363218784332, "2046": 0.25694093108177185, "20... | 36618603 | The differentiation in vitro of murine embryonic stem cells to embryoid bodies mimics events that occur in vivo shortly before and after embryonic implantation. We have used this system, together with differential cDNA cloning, to identify genes the expression of which is regulated during early embryogenesis. Here we d... | The murine H19 gene is activated during embryonic stem cell differentiation in vitro and at the time of implantation in the developing embryo. |
{"1011": 0.11256109178066254, "1015": 0.016465263441205025, "1016": 0.31845372915267944, "1017": 0.2667117714881897, "1018": 0.19622190296649933, "1042": 0.4356052577495575, "1997": 0.040196798741817474, "1999": 0.14179791510105133, "2007": 0.5104349255561829, "2008": 0.129004567861557, "2011": 0.36697331070899963, "20... | 36623997 | In wild-type budding yeast strains, the proteins encoded by SIR3, SIR4 and RAP1 co-localize with telomeric DNA in a limited number of foci in interphase nuclei. Immunostaining of Sir2p shows that in addition to a punctate staining that coincides with Rap1 foci, Sir2p localizes to a subdomain of the nucleolus. The prese... | Localization of Sir2p: the nucleolus as a compartment for silent information regulators. |
{"1011": 0.3443928062915802, "1020": 0.11604541540145874, "2004": 0.10467668622732162, "2011": 0.14349138736724854, "2013": 0.23556606471538544, "2015": 0.3897167444229126, "2020": 0.18248429894447327, "2029": 0.11517547070980072, "2034": 0.21530038118362427, "2043": 0.14686977863311768, "2044": 0.28743788599967957, "2... | 36637129 | Reprogramming of somatic cells into pluripotency stem cell state has opened new opportunities in cell replacement therapy and disease modeling in a number of neurological disorders. It still remains unknown, however, to what degree the grafted human-induced pluripotent stem cells (hiPSCs) differentiate into a functiona... | Optogenetics reveal delayed afferent synaptogenesis on grafted human-induced pluripotent stem cell-derived neural progenitors. |
{"1009": 0.45251765847206116, "1011": 0.24631060659885406, "1014": 0.03925827145576477, "1015": 1.059443712234497, "1017": 0.2089812457561493, "1022": 0.16359257698059082, "1023": 0.02887592278420925, "1043": 0.030771657824516296, "1045": 0.3304552733898163, "1048": 0.3656192123889923, "1052": 0.4002431631088257, "1056... | 36642096 | BACKGROUND Type 1 diabetes mellitus is a chronic autoimmune disease caused by the pathogenic action of T lymphocytes on insulin-producing beta cells. Previous clinical studies have shown that continuous immune suppression temporarily slows the loss of insulin production. Preclinical studies suggested that a monoclonal ... | Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus. |
{"1011": 0.23787821829319, "1015": 0.31845372915267944, "1017": 0.11691460013389587, "1018": 0.5092619061470032, "1044": 0.6435998678207397, "1999": 0.23479416966438293, "2005": 0.10291612148284912, "2006": 0.18816383183002472, "2011": 0.17840765416622162, "2013": 0.0606246218085289, "2020": 0.045809537172317505, "2024... | 36651210 | Embryonic stem cells have the ability to remain undifferentiated and proliferate indefinitely in vitro while maintaining the potential to differentiate into derivatives of all three embryonic germ layers. These cells have, therefore, potential for in vitro differentiation studies, gene function, and so on. The aim of t... | Establishment and in vitro differentiation of a new embryonic stem cell line from human blastocyst. |
{"1048": 0.06977381557226181, "1999": 0.20421554148197174, "2004": 0.11256109178066254, "2005": 0.04953393340110779, "2006": 0.1384023278951645, "2011": 0.016465263441205025, "2013": 0.040196798741817474, "2029": 0.1485546976327896, "2039": 0.29036402702331543, "2050": 0.7755908370018005, "2063": 0.30558720231056213, "... | 36653415 | Cancer cells consume glucose and secrete lactate in culture. It is unknown whether lactate contributes to energy metabolism in living tumors. We previously reported that human non-small-cell lung cancers (NSCLCs) oxidize glucose in the tricarboxylic acid (TCA) cycle. Here, we show that lactate is also a TCA cycle carbo... | Lactate Metabolism in Human Lung Tumors |
{"1043": 0.04207121208310127, "1999": 0.16442140936851501, "2002": 0.006812678650021553, "2004": 0.006812678650021553, "2010": 0.8731874823570251, "2011": 0.2969166338443756, "2012": 0.5822374224662781, "2019": 0.0058422754518687725, "2029": 0.15442965924739838, "2046": 0.27712854743003845, "2061": 0.6823468804359436, ... | 36654066 | Methionine is converted by the transmethylation/transsulfuration pathway to homocysteine which may exert atherogenic effects by several mechanisms, including lipid peroxidation. Therefore, the excessive dietary methionine may induce the development of atherosclerosis. To test this hypothesis, plasma and aortic thiobarb... | Increased lipid peroxidation as a mechanism of methionine-induced atherosclerosis in rabbits. |
{"1011": 0.29328158497810364, "1013": 0.10731173306703568, "1016": 0.004870930220931768, "1017": 0.21135559678077698, "1020": 0.43244171142578125, "1023": 0.2719337046146393, "1038": 0.2918238639831543, "1041": 0.6233867406845093, "1052": 0.29109421372413635, "1057": 0.8281423449516296, "1060": 0.966567873954773, "1061... | 36708463 | A major question is whether genes encoded on the sex chromosomes act directly in non-gonadal tissues to cause sex differences in development or function, or whether all sex differences in somatic tissues are induced by gonadal secretions. As part of this question we asked whether mouse X-Y homologous gene pairs are exp... | Sex differences in sex chromosome gene expression in mouse brain. |
{"1011": 0.14602625370025635, "1043": 0.055094651877880096, "1048": 0.37102460861206055, "2003": 0.04767346754670143, "2011": 0.16276304423809052, "2013": 0.15023678541183472, "2015": 0.25239890813827515, "2024": 0.026025565341114998, "2029": 0.056018441915512085, "2090": 0.35745587944984436, "2094": 0.0486041344702243... | 36713289 | An increasing number of human diseases are recognized to result from recurrent DNA rearrangements involving unstable genomic regions. These are termed genomic disorders, in which the clinical phenotype is a consequence of abnormal dosage of gene(s) located within the rearranged genomic fragments. Both inter- and intrac... | Genome architecture, rearrangements and genomic disorders. |
{"1003": 0.11865071207284927, "1011": 0.43244171142578125, "1052": 0.006812678650021553, "1053": 0.8264343738555908, "1998": 0.27044451236724854, "2007": 0.48610860109329224, "2029": 0.17020416259765625, "2053": 0.5629584193229675, "2062": 0.401551216840744, "2064": 0.23402166366577148, "2067": 0.8442239761352539, "207... | 36721932 | OBJECTIVE Nociceptive and neuropathic components both contribute to pain. Since these components require different pain management strategies, correct pain diagnosis before and during treatment is highly desirable. As low back pain (LBP) patients constitute an important subgroup of chronic pain patients, we addressed t... | painDETECT: a new screening questionnaire to identify neuropathic components in patients with back pain. |
{"1042": 0.6296497583389282, "2005": 0.3019835948944092, "2012": 0.3325583338737488, "2029": 0.05786345899105072, "2048": 0.4574742913246155, "2052": 0.05970508232712746, "2075": 0.3170322775840759, "2090": 0.08782484382390976, "2109": 0.1693800985813141, "2117": 0.09050461649894714, "2128": 0.6838265657424927, "2129":... | 36749390 | Purpose To propose a semiquantitative dual fluorescein angiography (FA) and indocyanine green angiography (ICGA) scoring system for uveitis that would assist in the follow-up of disease progression and monitoring response to treatment. Methods The scoring system was based on the FA scoring systems, the standardized ICG... | Scoring of dual fluorescein and ICG inflammatory angiographic signs for the grading of posterior segment inflammation (dual fluorescein and ICG angiographic scoring system for uveitis) |
{"2003": 0.36358460783958435, "2019": 0.5495203733444214, "2072": 1.3989098072052002, "2401": 0.04953393340110779, "2465": 0.20977331697940826, "2470": 0.11951763927936554, "2483": 0.6170841455459595, "2504": 0.3995884954929352, "2668": 0.16607704758644104, "2817": 0.17267228662967682, "2832": 0.10555581003427505, "284... | 36799998 | Acute kidney injury (AKI) is a complex disorder comprising several etiological factors and occurring in multiple settings. The disorder has a variety of clinical manifestations that range from minimal elevation in serum creatinine level to anuric renal failure. We describe the formation of a multidisciplinary collabora... | Improving outcomes of acute kidney injury: report of an initiative |
{"1011": 0.31132611632347107, "1017": 0.4450363218784332, "1018": 0.32129061222076416, "1022": 0.1401015669107437, "1040": 0.27786844968795776, "1042": 0.37640097737312317, "1048": 0.5010119676589966, "1056": 0.319873183965683, "1060": 0.2852376699447632, "1061": 1.0933903455734253, "1999": 0.11951763927936554, "2005":... | 36816310 | Sorting signals for cargo selection into coated vesicles are usually in the form of short linear motifs. Three motifs for clathrin-mediated endocytosis have been identified: YXXPhi, [D/E]XXXL[L/I] and FXNPXY. To search for new endocytic motifs, we made a library of CD8 chimeras with random sequences in their cytoplasmi... | A Screen for Endocytic Motifs |
{"1044": 0.18167030811309814, "1156": 0.3897167444229126, "2005": 0.1808556467294693, "2011": 0.1477125883102417, "2044": 0.5696102976799011, "2064": 0.04953393340110779, "2067": 0.4914994537830353, "2079": 0.18978065252304077, "2083": 0.030771657824516296, "2106": 0.08244366943836212, "2109": 0.08871890604496002, "212... | 36830715 | Hypertrophic scarring and poor intrinsic axon growth capacity constitute major obstacles for spinal cord repair. These processes are tightly regulated by microtubule dynamics. Here, moderate microtubule stabilization decreased scar formation after spinal cord injury in rodents through various cellular mechanisms, inclu... | Microtubule stabilization reduces scarring and causes axon regeneration after spinal cord injury. |
{"1038": 0.2223619967699051, "2002": 0.1677299439907074, "2003": 0.08692999184131622, "2010": 1.0782235860824585, "2044": 0.04953393340110779, "2049": 0.11865071207284927, "2076": 0.06886265426874161, "2079": 0.272677481174469, "2109": 0.03360854089260101, "2128": 0.015504186972975731, "2206": 0.18573370575904846, "231... | 36831892 | Considerable energetic investment is devoted to altering large stretches of chromatin adjacent to DNA double strand breaks (DSBs). Immediately ensuing DSB formation, a myriad of histone modifications are elicited to create a platform for inducible and modular assembly of DNA repair protein complexes in the vicinity of ... | Histone tails: Directing the chromatin response to DNA damage. |
{"1015": 0.5074998140335083, "1050": 0.006812678650021553, "1052": 0.15693697333335876, "1057": 0.0842406153678894, "2004": 0.0174254160374403, "2011": 0.39762192964553833, "2015": 0.5278670787811279, "2028": 0.20421554148197174, "2029": 0.3134697377681732, "2058": 0.45994341373443604, "2063": 0.12986256182193756, "207... | 36838958 | Uncoupling protein 1 (Ucp1), which is localized in the mitochondrial inner membrane of mammalian brown adipose tissue (BAT), generates heat by uncoupling oxidative phosphorylation. Upon cold exposure or nutritional abundance, sympathetic neurons stimulate BAT to express Ucp1 to induce energy dissipation and thermogenes... | Sestrin2 inhibits uncoupling protein 1 expression through suppressing reactive oxygen species. |
{"1005": 0.12728634476661682, "1011": 0.32764431834220886, "1015": 0.2493593990802765, "1017": 0.35745587944984436, "1018": 0.0038986403960734606, "1019": 0.3262358605861664, "1020": 0.12556517124176025, "1043": 0.6244332790374756, "1060": 0.3409265875816345, "1997": 0.025073638185858727, "1999": 0.06612417846918106, "... | 36855703 | XPG is a member of the FEN-1 structure-specific endonuclease family. It has 3'-junction cutting activity on bubble substrates and makes the 3'-incision in the human dual incision (excision nuclease) repair system. To investigate the precise role of XPG in nucleotide excision repair, we mutagenized two amino acid residu... | The non-catalytic function of XPG protein during dual incision in human nucleotide excision repair. |
{"1011": 0.0913962796330452, "1054": 0.2659635543823242, "1997": 0.21214580535888672, "2012": 0.29109421372413635, "2014": 0.19862671196460724, "2015": 0.23247487843036652, "2019": 0.3547199070453644, "2028": 0.05046287178993225, "2034": 0.022212404757738113, "2043": 0.17267228662967682, "2044": 0.1734936386346817, "20... | 36860856 | Computer techniques readily extract from the brainwaves an orderly sequence of brain potentials locked in time to sound stimuli. The potentials that appear 8 to 80 msec after the stimulus resemble 3 or 4 cycles of a 40-Hz sine wave; we show here that these waves combined to form a single, stable, composite wave when th... | A 40-Hz auditory potential recorded from the human scalp. |
{"1050": 0.0009760859538801014, "1060": 0.7463917136192322, "1996": 0.04113444685935974, "1999": 0.12038381397724152, "2004": 0.10026945173740387, "2007": 0.020300358533859253, "2008": 0.043007105588912964, "2011": 0.07612881064414978, "2029": 0.2247048318386078, "2037": 0.022212404757738113, "2050": 0.3120411634445190... | 36889513 | Bile acids regulate the transcription of genes that control cholesterol homeostasis through molecular mechanisms that are poorly understood. Physiological concentrations of free and conjugated chenodeoxycholic acid, lithocholic acid, and deoxycholic acid activated the farnesoid X receptor (FXR; NR1H4), an orphan nuclea... | Bile acids: natural ligands for an orphan nuclear receptor. |
{"1011": 0.0058422754518687725, "1017": 0.036437395960092545, "1048": 0.6533012986183167, "1054": 0.9769153594970703, "1997": 0.09050461649894714, "2003": 0.00875066313892603, "2005": 0.004870930220931768, "2007": 0.2493593990802765, "2011": 0.1685553640127182, "2013": 0.16690383851528168, "2029": 0.1693800985813141, "... | 36904081 | The yeast ribosomal protein gene RPL32 of Saccharomyces cerevisiae is of particular interest for two reasons: 1) it is adjacent to another ribosomal protein gene, RP29, whose divergent transcription may be driven from the same control sequences, and 2) it appears that the splicing of its transcript is regulated by the ... | The yeast ribosomal protein L32 and its gene. |
{"1006": 0.0317181795835495, "1011": 0.21530038118362427, "1039": 0.4113073945045471, "1055": 0.43623676896095276, "1060": 1.1031591892242432, "2007": 0.043007105588912964, "2011": 0.27564704418182373, "2012": 0.15526613593101501, "2013": 0.07884006202220917, "2024": 0.040196798741817474, "2029": 0.32129061222076416, "... | 36921186 | Female human induced pluripotent stem cell (hiPSC) lines exhibit variability in X-inactivation status. The majority of hiPSC lines maintain one transcriptionally active X (Xa) and one inactive X (Xi) chromosome from donor cells. However, at low frequency, hiPSC lines with two Xas are produced, suggesting that epigeneti... | Derivation conditions impact X-inactivation status in female human induced pluripotent stem cells. |
{"1011": 0.23556606471538544, "1014": 0.3777405619621277, "1019": 0.9673105478286743, "1026": 0.27564704418182373, "1040": 0.26446542143821716, "1050": 0.27786844968795776, "1052": 0.35677260160446167, "1999": 0.09406650811433792, "2007": 0.0354953333735466, "2026": 0.3910386264324188, "2029": 0.3485364317893982, "2058... | 36950726 | Several research groups have recently reported on markedly reduced levels of 5-hydroxymethylcytosine (5hmC) in human breast, liver, lung, pancreatic, colon, prostate, brain, and myeloid cancers. We studied benign compound nevi (BCN, n=17), dysplastic compound nevi (DCN, n=15), superficial spreading melanomas [SSM, stra... | Loss of 5-hydroxymethylcytosine and ten-eleven translocation 2 protein expression in malignant melanoma. |
{"1013": 0.07612881064414978, "1014": 0.21765978634357452, "1019": 0.18248429894447327, "1021": 0.20977331697940826, "1040": 1.197703242301941, "1048": 0.08154398202896118, "1059": 0.15943801403045654, "1060": 0.11865071207284927, "1061": 0.15275461971759796, "2000": 0.07341018319129944, "2005": 0.08244366943836212, "2... | 36960449 | BACKGROUND Knowledge gaps have contributed to considerable variation among international dietary recommendations for vitamin D. OBJECTIVE We aimed to establish the distribution of dietary vitamin D required to maintain serum 25-hydroxyvitamin D [25(OH)D] concentrations above several proposed cutoffs (ie, 25, 37.5, 50... | Estimation of the dietary requirement for vitamin D in healthy adults. |
{"1011": 0.1751343309879303, "1015": 0.567397952079773, "1044": 0.083342544734478, "1047": 0.5336109399795532, "1048": 0.29109421372413635, "1052": 1.034073829650879, "1054": 0.18329764902591705, "1997": 0.007782140281051397, "1998": 0.13670019805431366, "2002": 0.052318159490823746, "2007": 0.04767346754670143, "2008"... | 36962270 | We have modified an Escherichia coli vector expressing 66-kDa HIV-1 reverse transcriptase (p66) so that it simultaneously expresses this and the pol-coded protease. The twin expression cassette yields high quantities of both reverse transcriptase and protease; however, under these conditions, 50% of the over-expressed ... | Rapid purification of homodimer and heterodimer HIV-1 reverse transcriptase by metal chelate affinity chromatography. |
{"1006": 0.16607704758644104, "1046": 0.3662964701652527, "1997": 0.06795065850019455, "1999": 0.4788752794265747, "2007": 0.30558720231056213, "2008": 0.0354953333735466, "2011": 0.04953393340110779, "2013": 0.2881702482700348, "2015": 0.18411032855510712, "2029": 0.27342069149017334, "2049": 0.12986256182193756, "205... | 36991551 | Abstract Some cocoas and chocolates are rich in ()epicatechin and its related oligomers, the procyanidins. Fractions of these compounds, isolated from the seeds of Theobroma cacao, caused dosedependent inhibition of isolated rabbit 15-lipoxygenase-1 with the larger oligomers being more active; the decamer fraction reve... | Polyphenols of Cocoa: Inhibition of Mammalian 15-Lipoxygenase |
{"1011": 0.2089812457561493, "1041": 0.49864232540130615, "1044": 0.5450005531311035, "1053": 0.6754127144813538, "1997": 0.5723689198493958, "1998": 0.09495500475168228, "2001": 0.09228714555501938, "2002": 0.2822965085506439, "2007": 0.42735910415649414, "2020": 0.17267228662967682, "2050": 0.08603433519601822, "2090... | 37029185 | Although evaluation of the treatment of congestive heart failure is usually based on objective clinical outcomes, patient self-assessment is increasingly recognized as an important component of evaluation. A study was designed to measure the quality of life of 134 patients with symptoms of advanced heart failure who we... | Quality of life in patients with advanced heart failure. |
{"1009": 0.44753631949424744, "1020": 0.27564704418182373, "1041": 0.417115718126297, "1049": 0.22001366317272186, "1054": 1.024303913116455, "1055": 0.14264501631259918, "1058": 0.07159364968538284, "1059": 0.14602625370025635, "2007": 0.07793712615966797, "2012": 0.21372433006763458, "2019": 0.42735910415649414, "202... | 37037012 | This study was designed to determine whether cardiac vagal afferents exert an inhibitory influence on increases in regional vascular resistance during exercise and to determine whether endurance exercise training enhances the inhibitory influence of cardiac vagal afferents. We measured changes in regional vascular resi... | Regional vascular resistance during exercise: role of cardiac afferents and exercise training. |
{"1014": 0.28670501708984375, "1039": 0.12728634476661682, "1047": 0.10026945173740387, "1052": 0.4709797203540802, "2005": 0.05139094591140747, "2025": 0.15860503911972046, "2042": 0.1011524572968483, "2062": 0.3409265875816345, "2064": 0.13499516248703003, "2071": 0.15526613593101501, "2078": 0.2800849378108978, "208... | 37065914 | BACKGROUND AND PURPOSE Soluble corin was decreased in coronary heart disease. Given the connections between cardiac dysfunction and stroke, circulating corin might be a candidate marker of stroke risk. However, the association between circulating corin and stroke has not yet been studied in humans. Here, we aimed to ex... | Serum Soluble Corin is Decreased in Stroke. |
{"1003": 0.009718249551951885, "1014": 0.5427330136299133, "1018": 0.23633737862110138, "1039": 0.0058422754518687725, "1051": 0.12986256182193756, "1052": 0.4337083101272583, "2001": 0.09228714555501938, "2002": 0.09406650811433792, "2003": 0.1889725625514984, "2011": 0.1332872211933136, "2012": 0.16690383851528168, "... | 37118634 | BACKGROUND Umbilical cord infection (omphalitis) is a risk factor for neonatal sepsis and mortality in low-resource settings where home deliveries are common. We aimed to assess the effect of umbilical-cord cleansing with 4% chlorhexidine (CHX) solution, with or without handwashing with antiseptic soap, on the incidenc... | Topical application of chlorhexidine to neonatal umbilical cords for prevention of omphalitis and neonatal mortality in a rural district of Pakistan: a community-based, cluster-randomised trial. |
{"1011": 0.2837681770324707, "1017": 0.1229778528213501, "1047": 0.6989894509315491, "1050": 0.8756314516067505, "1061": 0.22079704701900482, "1164": 0.5381823778152466, "1996": 0.35403475165367126, "1997": 0.14349138736724854, "1999": 0.06703783571720123, "2003": 0.2696990668773651, "2008": 0.03360854089260101, "2015"... | 37138639 | The IKK kinase complex is the core element of the NF-kappaB cascade. It is essentially made of two kinases (IKKalpha and IKKbeta) and a regulatory subunit, NEMO/IKKgamma. Additional components may exist, transiently or permanently, but their characterization is still unsure. In addition, it has been shown that two sepa... | The IKK complex, a central regulator of NF-kappaB activation. |
{"2007": 0.25694093108177185, "2031": 0.09406650811433792, "2038": 0.058784693479537964, "2043": 0.09938567131757736, "2045": 0.06886265426874161, "2064": 0.30989447236061096, "2071": 0.010684899985790253, "2077": 0.0038986403960734606, "2079": 0.08871890604496002, "2109": 0.3409265875816345, "2116": 0.3560888469219208... | 37156349 | Independent mobility in early childhood has been associated with the development of various cognitive and psychosocial skills. However, children with physical disabilities are not always able to move independently and may be at risk for delays in these areas. Early provision of powered mobility can offer young children... | Cognitive predictors of young children's readiness for powered mobility. |
{"1011": 0.06612417846918106, "1017": 0.18004031479358673, "1049": 0.16276304423809052, "1052": 0.3850763738155365, "2007": 0.19381128251552582, "2015": 0.23479416966438293, "2026": 0.0797421783208847, "2029": 0.3547199070453644, "2033": 1.117955207824707, "2072": 0.6989894509315491, "2076": 0.1011524572968483, "2079":... | 37164306 | A key event in the mechanism of mouse embryonic stem cell (mESC) pluripotency is phosphorylation, dimerisation and translocation to the nucleus of the signal transducer and activator of transcription3, Stat3. We used RNAi to suppress the levels of the co-chaperone Hsp70/Hsp90 organising protein (Hop) in an mESC line. H... | Knockdown of the co-chaperone Hop promotes extranuclear accumulation of Stat3 in mouse embryonic stem cells. |
{"1006": 0.1734936386346817, "1011": 0.31560876965522766, "1016": 0.0797421783208847, "1038": 0.9944084882736206, "1040": 0.40806588530540466, "1046": 0.9271688461303711, "1058": 0.9769153594970703, "1061": 0.011650617234408855, "1998": 0.0029254043474793434, "2005": 0.08244366943836212, "2011": 0.3134697377681732, "20... | 37182501 | Two mechanisms account for generation of the human antibody repertoire; V(D)J recombination during the early stages of B-cell development in the bone marrow and somatic mutation of immunoglobulin genes in mature B cells responding to antigen in the periphery. V(D)J recombination produces diversity by random joining of ... | B-cell self-tolerance in humans. |
{"1011": 0.09317722171545029, "1020": 0.8534175157546997, "1039": 0.503966212272644, "1043": 0.15526613593101501, "1046": 1.2035820484161377, "1048": 0.23556606471538544, "1052": 0.6405166387557983, "2003": 0.18492233753204346, "2004": 0.10818854719400406, "2005": 0.029824240133166313, "2008": 0.02792670577764511, "202... | 37204802 | Jumonji domain-containing 6 (JMJD6) is a member of the Jumonji C domain-containing family of proteins. Compared to other members of the family, the cellular activity of JMJD6 is still not clearly defined and its biological function is still largely unexplored. Here we report that JMJD6 is physically associated with the... | JMJD6 Promotes Colon Carcinogenesis through Negative Regulation of p53 by Hydroxylation |
{"1039": 0.1913948506116867, "2001": 0.5925496220588684, "2005": 0.06977381557226181, "2007": 0.021256839856505394, "2013": 0.1212492436170578, "2018": 0.11256109178066254, "2019": 0.037378571927547455, "2020": 0.3339579105377197, "2034": 0.255429208278656, "2038": 0.34300774335861206, "2042": 0.6022219061851501, "2043... | 37205685 | Malaria resistant to chloroquine has now been confirmed in more than 40 countries. The drug was introduced in 1934, but was not in large-scale use until the early 1950s. Anecdotal reports suggest that resistance emerged as early as 1957 both in Colombia and along the then Cambodia-Thailand border area. But by 1960, res... | Spread of chloroquine resistance in Plasmodium falciparum. |
{"1011": 0.056018441915512085, "1019": 0.29255300760269165, "1042": 0.26296505331993103, "1050": 0.13071982562541962, "1051": 0.4151833653450012, "1059": 0.32129061222076416, "1164": 0.15610189735889435, "1999": 0.06612417846918106, "2008": 0.00875066313892603, "2011": 0.30917787551879883, "2012": 0.3615458607673645, "... | 37205759 | The Apolipoprotein (Apo) family is implicated in lipid metabolism. There are five types of Apo: Apoa, Apob, Apoc, Apod, and Apoe. Apoe has been demonstrated to play a central role in lipoprotein metabolism and to be essential for efficient receptor-mediated plasma clearance of chylomicron remnants and VLDL remnant part... | Obesity occurring in apolipoprotein E-knockout mice has mild effects on fertility. |
{"1016": 0.5500838756561279, "1042": 0.25995752215385437, "1996": 0.20501139760017395, "1997": 0.004870930220931768, "2011": 0.2231435477733612, "2013": 0.2674594223499298, "2015": 0.8022117614746094, "2025": 0.058784693479537964, "2031": 0.058784693479537964, "2038": 0.27786844968795776, "2039": 0.29981520771980286, "... | 37207226 | The heart has both the greatest caloric needs and the most robust oxidation of fatty acids (FAs). Under pathological conditions such as obesity and type 2 diabetes, cardiac uptake and oxidation are not balanced and hearts accumulate lipid potentially leading to cardiac lipotoxicity. We will first review the pathways ut... | Lipid metabolism and toxicity in the heart. |
{"1018": 0.09406650811433792, "1022": 0.18248429894447327, "1023": 0.1212492436170578, "1043": 0.02412080205976963, "2000": 0.19220098853111267, "2001": 0.4425300657749176, "2004": 0.3027053773403168, "2013": 0.1970241367816925, "2015": 0.03266380727291107, "2020": 0.41840189695358276, "2034": 0.42353010177612305, "204... | 37248570 | After a lapse of almost 40 years, malaria eradication is back on the global health agenda. Inspired by the Gates Malaria Forum in October 2007,1,2 key organizations are starting to debate the pros and cons of redefining eradication as an explicit goal of malaria control efforts. Attempts to eliminate malaria in souther... | Malaria eradication back on the table. |
{"1011": 0.40285754203796387, "1018": 0.29255300760269165, "1039": 0.3554046154022217, "1050": 0.8829278349876404, "1999": 0.08961215615272522, "2003": 0.32129061222076416, "2005": 0.45499902963638306, "2007": 0.3084607720375061, "2010": 0.8583967685699463, "2026": 0.7220231294631958, "2029": 0.10026945173740387, "2090... | 37248765 | N-acetyl-dinaline (CI-994) is an investigational anti-cancer drug which inhibits histone deacetylases. We evaluated the interaction between CI-994 and conventional chemotherapeutics used in acute myeloid leukemia (AML) in a rat model for AML and Brown Norway rat acute myelocytic leukemia (BNML). In vitro, CI-994 in com... | CI-994 (N-acetyl-dinaline) in combination with conventional anti-cancer agents is effective against acute myeloid leukemia in vitro and in vivo. |
{"1039": 0.07793712615966797, "1043": 0.27786844968795776, "1996": 0.06977381557226181, "1997": 0.04767346754670143, "2005": 0.11343330889940262, "2015": 0.07159364968538284, "2029": 0.22001366317272186, "2033": 0.2317005842924118, "2043": 0.1221139207482338, "2076": 0.574020504951477, "2079": 0.27934664487838745, "210... | 37249641 | Genome function, replication, integrity, and propagation rely on the dynamic structural organization of chromosomes during the cell cycle. Genome folding in interphase provides regulatory segmentation for appropriate transcriptional control, facilitates ordered genome replication, and contributes to genome integrity by... | CTCF and Cohesin in Genome Folding and Transcriptional Gene Regulation. |
{"1054": 0.2763880789279938, "1998": 0.01934296265244484, "2004": 0.0752234235405922, "2005": 0.04953393340110779, "2007": 0.2881702482700348, "2011": 0.0770333781838417, "2029": 0.2447827309370041, "2038": 0.0029254043474793434, "2050": 0.14179791510105133, "2079": 0.18978065252304077, "2090": 0.25995752215385437, "20... | 37256966 | Melatonin modulates a wide array of physiological events with pleiotropic effects on the immune system. While the relevance of specific melatonin membrane receptors has been well established for several biological functions, retinoic acid-related orphan receptor alpha (RORα) has been suggested as a mediator of nuclear ... | Melatonin synthesized by T lymphocytes as a ligand of the retinoic acid-related orphan receptor. |
{"1011": 0.016465263441205025, "1023": 0.4818955361843109, "1045": 0.8740028142929077, "1052": 0.4794800877571106, "1056": 0.5347557663917542, "1998": 0.11256109178066254, "1999": 0.013579257763922215, "2007": 0.10026945173740387, "2029": 0.18329764902591705, "2065": 0.6000806093215942, "2078": 0.46424978971481323, "21... | 37269418 | The cytokine and antibody response to Trichuris trichiura infection was determined for 96 persons living in an area where the parasite is highly endemic and infection exhibits a convex age intensity profile. In response to stimulation with T. trichiura antigen, a small proportion of the study group produced interleukin... | Age- and infection intensity-dependent cytokine and antibody production in human trichuriasis: the importance of IgE. |
{"1003": 0.2822965085506439, "1011": 0.14179791510105133, "1013": 0.12986256182193756, "1014": 0.39893341064453125, "1048": 0.4196864068508148, "1997": 0.1384023278951645, "1999": 0.2918238639831543, "2000": 0.25239890813827515, "2005": 0.4248080551624298, "2007": 0.24171993136405945, "2011": 0.14602625370025635, "2012... | 37296667 | In order to improve boar sperm quality during frozen-thawed process, the influence of the presence of trehalose on success of cryopreservation of boar sperm were investigated. We evaluated freeze-thawing tolerance of boar spermatozoa in a base cooling extender with the addition of different trehalose concentrations (0,... | The cryoprotective effect of trehalose supplementation on boar spermatozoa quality. |
{"1038": 0.08513788133859634, "1044": 0.010684899985790253, "1052": 0.23092569410800934, "1055": 0.6054253578186035, "2003": 0.016465263441205025, "2011": 0.08513788133859634, "2029": 0.20739519596099854, "2039": 0.08244366943836212, "2042": 0.014542185701429844, "2043": 0.09938567131757736, "2046": 0.00971824955195188... | 37297740 | Polyploidy, recognized by multiple copies of the haploid chromosome number, has been described in plants, insects, and in mammalian cells such as, the platelet precursors, the megakaryocytes. Several of these cell types reach high ploidy via a different cell cycle. Megakaryocytes undergo an endomitotic cell cycle, whic... | Roads to polyploidy: the megakaryocyte example. |
{"1011": 0.09228714555501938, "1048": 0.603290855884552, "1056": 1.1683861017227173, "1996": 0.23864774405956268, "1998": 0.15693697333335876, "2003": 0.11691460013389587, "2004": 0.052318159490823746, "2008": 0.0009760859538801014, "2029": 0.3106105625629425, "2048": 0.04394211992621422, "2058": 0.13243216276168823, "... | 37311371 | The memory T cell pool functions as a dynamic repository of antigen-experienced T lymphocytes that accumulate over the lifetime of the individual. Recent studies indicate that memory T lymphocytes contain distinct populations of central memory (TCM) and effector memory (TEM) cells characterized by distinct homing capac... | Central memory and effector memory T cell subsets: function, generation, and maintenance. |
{"1011": 0.014542185701429844, "1018": 0.46363574266433716, "1038": 0.8845420479774475, "1998": 0.1685553640127182, "2000": 0.13755162060260773, "2002": 0.6563454270362854, "2005": 0.19782574474811554, "2006": 0.09050461649894714, "2011": 0.37035053968429565, "2012": 0.18978065252304077, "2029": 0.2749055027961731, "20... | 37328025 | Cells cope with blockage of replication fork progression in a manner that allows DNA synthesis to be completed and genomic instability minimized. Models for resolution of blocked replication involve fork regression to form Holliday junction structures. The human RecQ helicases WRN and BLM (deficient in Werner and Bloom... | The Werner and Bloom syndrome proteins help resolve replication blockage by converting (regressed) holliday junctions to functional replication forks. |
{"1011": 0.2561853528022766, "1014": 0.3656192123889923, "1026": 0.17922431230545044, "1028": 0.09850110858678818, "1050": 0.674915611743927, "1052": 0.619189441204071, "1998": 0.1685553640127182, "1999": 0.07431721687316895, "2005": 0.009718249551951885, "2006": 0.09672962874174118, "2007": 0.21687394380569458, "2010"... | 37336085 | PURPOSE We assessed the nephroprotective effects of montelukast sodium and N-acetylcysteine on secondary renal damage due to unilateral ureteral obstruction in a rat model. MATERIALS AND METHODS In this study 30 Wistar albino male rats were randomized into 3 groups, including placebo, N-acetylcysteine and montelukast s... | Do Montelukast Sodium and N-Acetylcysteine Have a Nephroprotective Effect on Unilateral Ureteral Obstruction? A Placebo Controlled Trial in a Rat Model. |
{"1011": 0.034552380442619324, "1045": 0.31132611632347107, "1051": 0.5381823778152466, "1058": 0.2659635543823242, "1996": 0.20660123229026794, "1997": 0.22079704701900482, "1999": 0.0354953333735466, "2003": 0.03360854089260101, "2011": 0.3170322775840759, "2013": 0.05046287178993225, "2015": 0.010684899985790253, "2... | 37362689 | The bulk of ATP consumed by various cellular processes in higher eukaryotes is normally produced by five multimeric protein complexes (I-V) embedded within the inner mitochondrial membrane, in a process known as oxidative phosphorylation (OXPHOS). Maintenance of energy homeostasis under most physiological conditions is... | Oxidative phosphorylation: synthesis of mitochondrially encoded proteins and assembly of individual structural subunits into functional holoenzyme complexes. |
{"1005": 0.04487626627087593, "1017": 0.0058422754518687725, "1041": 0.1064341589808464, "1043": 0.18167030811309814, "1044": 0.09495500475168228, "1055": 0.4831010699272156, "2003": 0.018384648486971855, "2007": 0.5139457583427429, "2013": 0.08513788133859634, "2015": 0.2184450328350067, "2018": 0.2447827309370041, "2... | 37405449 | The family of an elderly man with Barrett's esophagus was examined for gastroesophageal reflux and development of Barrett's esophagus. All five living children have gastroesophageal reflux or esophagitis, or both, and three have unequivocal Barrett's esophagus. Two third-generation descendents have gastroesophageal ref... | Familial gastroesophageal reflux and development of Barrett's esophagus. |
{"1014": 0.4481603503227234, "1038": 0.3916989266872406, "1042": 1.0755622386932373, "1052": 0.3910386264324188, "1998": 0.41195443272590637, "2007": 0.13925230503082275, "2012": 0.3325583338737488, "2025": 0.1401015669107437, "2029": 0.17020416259765625, "2048": 0.1011524572968483, "2053": 0.31132611632347107, "2090":... | 37424881 | OBJECTIVE Folate and vitamin B12 are two vital regulators in the metabolic process of homocysteine, which is a risk factor of atherothrombotic events. Low folate intake or low plasma folate concentration is associated with increased stroke risk. Previous randomized controlled trials presented discordant findings in the... | The effect of folate fortification on folic acid-based homocysteine-lowering intervention and stroke risk: a meta-analysis. |
{"1011": 0.34922540187835693, "2000": 0.4132472574710846, "2015": 0.8161250352859497, "2024": 0.03831886500120163, "2033": 0.8625272512435913, "2079": 0.015504186972975731, "2089": 0.16524957120418549, "2090": 0.037378571927547455, "2100": 0.40546512603759766, "2109": 0.40546512603759766, "2110": 0.0019512200960889459,... | 37437064 | Mesenchymal stem cells (MSCs) display substantial cell-to-cell variation. This heterogeneity manifests among donors, among tissue sources, and within cell populations. Such pervasive variability complicates the use of MSCs in regenerative applications and may limit their therapeutic efficacy. Most conventional assays m... | On the origin and impact of mesenchymal stem cell heterogeneity: new insights and emerging tools for single cell analysis. |
{"1011": 0.25467249751091003, "1015": 0.02887592278420925, "1999": 0.014542185701429844, "2005": 0.1212492436170578, "2013": 0.20818853378295898, "2015": 0.1011524572968483, "2020": 0.10379679501056671, "2026": 0.4879087805747986, "2029": 0.18411032855510712, "2050": 0.6533012986183167, "2058": 0.2822965085506439, "206... | 37438296 | Age-dependent decline in skeletal muscle function leads to several inherited and acquired muscular disorders in elderly individuals. The levels of microRNAs (miRNAs) could be altered during muscle maintenance and repair. We therefore performed a comprehensive investigation for miRNAs from five different periods of bovi... | Altered microRNA expression in bovine skeletal muscle with age. |
{"1009": 0.3916989266872406, "1011": 0.02412080205976963, "1015": 0.6011518239974976, "1018": 0.07884006202220917, "1022": 0.07159364968538284, "1039": 0.19381128251552582, "1045": 0.011650617234408855, "1048": 0.2493593990802765, "1056": 1.004473328590393, "2008": 0.040196798741817474, "2011": 0.22626367211341858, "20... | 37444589 | Although 13 years have passed since identification of human immunodeficiency virus-1 (HIV-1) as the cause of AIDS, we do not yet know how HIV kills its primary target, the T cell that carries the CD4 antigen. We and others have shown an increase in the percentage of apoptotic cells among circulating CD4+ (and CD8+) T c... | Apoptosis occurs predominantly in bystander cells and not in productively infected cells of HIV- and SIV-infected lymph nodes |
{"1011": 0.23479416966438293, "1037": 0.5968599319458008, "1047": 0.603290855884552, "1050": 1.2134976387023926, "1055": 0.043007105588912964, "1996": 0.18978065252304077, "1997": 0.3499138653278351, "1999": 0.1994270235300064, "2003": 0.2223619967699051, "2015": 0.33953672647476196, "2024": 0.12814582884311676, "2029"... | 37450671 | The protein component of Alzheimer's disease amyloid [neurofibrillary tangles (NFT), amyloid plaque core and congophilic angiopathy] is an aggregated polypeptide with a subunit mass of 4 kd (the A4 monomer). Based on the degree of N-terminal heterogeneity, the amyloid is first deposited in the neuron, and later in the ... | Neuronal origin of a cerebral amyloid: neurofibrillary tangles of Alzheimer's disease contain the same protein as the amyloid of plaque cores and blood vessels. |
{"1014": 0.11343330889940262, "1043": 0.3615458607673645, "1998": 0.05139094591140747, "1999": 0.09584271162748337, "2001": 0.053244512528181076, "2015": 0.13925230503082275, "2020": 0.22937409579753876, "2039": 0.28082266449928284, "2040": 0.007782140281051397, "2042": 0.12986256182193756, "2043": 0.10993985831737518,... | 37480103 | CONTEXT During pregnancy, serum levels of estrogen, progesterone, and other hormones are markedly higher than during other periods of life. Pregnancy hormones primarily are produced in the placenta, and signs of placental impairment may serve as indirect markers of hormone exposures during pregnancy. During pregnancy, ... | Pregnancy characteristics and maternal risk of breast cancer. |
{"1011": 0.29619070887565613, "1014": 0.37371641397476196, "1017": 0.13157635927200317, "1018": 0.1718502640724182, "1044": 0.16110190749168396, "1054": 0.9805850982666016, "2001": 0.0354953333735466, "2004": 0.1384023278951645, "2005": 0.04394211992621422, "2007": 0.16276304423809052, "2014": 0.9710156321525574, "2016... | 37488367 | OBJECTIVE To investigate heritability and continuum versus categorical approaches to attention-deficit hyperactivity disorder (ADHD), using a large-scale twin sample. METHOD A cohort of 1,938 families with twins and siblings aged 4 to 12 years, recruited from the Australian National Health and Medical Research Council ... | Attention-deficit hyperactivity disorder: a category or a continuum? Genetic analysis of a large-scale twin study. |
{"1011": 0.3134697377681732, "1016": 0.6430866718292236, "1038": 0.06337817758321762, "1039": 0.7907629609107971, "1048": 0.4770587682723999, "2000": 0.11256109178066254, "2004": 0.004870930220931768, "2005": 0.1384023278951645, "2006": 0.5232481360435486, "2008": 0.006812678650021553, "2011": 0.272677481174469, "2012"... | 37549932 | Resistance to apoptosis, often achieved by the overexpression of antiapoptotic proteins, is common and perhaps required in the genesis of cancer. However, it remains uncertain whether apoptotic defects are essential for tumor maintenance. To test this, we generated mice expressing a conditional BCL-2 gene and constitut... | Antiapoptotic BCL-2 is required for maintenance of a model leukemia. |
{"1017": 0.13414156436920166, "1021": 0.07793712615966797, "1042": 0.07159364968538284, "1051": 0.7863243818283081, "1999": 0.6492279767990112, "2004": 0.40741631388664246, "2005": 0.04394211992621422, "2006": 0.05694137513637543, "2010": 0.6833335757255554, "2020": 0.011650617234408855, "2029": 0.029824240133166313, "... | 37562370 | OBJECTIVE The infrapatellar fat pad (IPFP) has been identified as a source of anterior knee pain. Fibrosis and marked inflammatory infiltrate in the IPFP of patients with arthritis of the knee and reduction in pain post knee replacement in patients following resection of the IPFP have been observed. We have investigate... | Cellular and histopathological changes in the infrapatellar fat pad in the monoiodoacetate model of osteoarthritis pain. |
{"1042": 0.28597161173820496, "1058": 0.1358480453491211, "2002": 0.7352184057235718, "2004": 0.09495500475168228, "2012": 0.37102460861206055, "2019": 0.0058422754518687725, "2021": 0.07793712615966797, "2026": 0.5762182474136353, "2033": 0.5220900774002075, "2038": 0.053244512528181076, "2042": 0.14433705806732178, "... | 37578311 | Although essentially unknown as a therapeutic concept as recently as a decade ago, it is difficult now to open a cardiology journal, attend a cardiology meeting, or scan a newspaper without being caught up in the excitement generated by the thought that angiogenesis therapy may soon have a major impact on the treatment... | Angiogenesis therapy: amidst the hype, the neglected potential for serious side effects. |
{"1014": 0.38174858689308167, "1017": 0.22157983481884003, "1038": 0.9531047344207764, "1043": 0.659380316734314, "1050": 0.4481603503227234, "1052": 0.6674286723136902, "1055": 0.11430477350950241, "1996": 0.07159364968538284, "1999": 0.09761575609445572, "2004": 0.2719337046146393, "2007": 0.0174254160374403, "2012":... | 37583120 | OBJECTIVE Obesity and being overweight during adulthood have been consistently linked to increased risk for development of dementia later in life, especially Alzheimer's disease. They have also been associated with cognitive dysfunction and brain structural alterations in otherwise healthy adults. Although proton magne... | Body mass index and magnetic resonance markers of brain integrity in adults. |
{"1041": 0.029824240133166313, "1056": 0.48670899868011475, "2006": 0.1734936386346817, "2007": 0.2478361576795578, "2011": 0.012615402229130268, "2020": 0.04674193635582924, "2029": 0.021256839856505394, "2033": 0.7565253376960754, "2044": 0.2954642176628113, "2076": 0.4190443754196167, "2077": 0.083342544734478, "209... | 37592824 | Sixty-seven patients with temporal lobe epilepsy without circumscribed, potentially epileptogenic lesions, who were studied with intracranial electrodes and who became seizure free following temporal lobectomy were retrospectively evaluated with regard to preoperative scalp electroencephalographic (EEG) findings, neuro... | Characteristics of medial temporal lobe epilepsy: II. Interictal and ictal scalp electroencephalography, neuropsychological testing, neuroimaging, surgical results, and pathology. |
{"1015": 0.0770333781838417, "1051": 0.1064341589808464, "1996": 0.20102575421333313, "1999": 0.25694093108177185, "2003": 0.11343330889940262, "2011": 0.2674594223499298, "2012": 0.3949938118457794, "2024": 0.23556606471538544, "2029": 0.2026219218969345, "2050": 0.42353010177612305, "2063": 0.841701865196228, "2076":... | 37608303 | Cristae, the organized invaginations of the mitochondrial inner membrane, respond structurally to the energetic demands of the cell. The mechanism by which these dynamic changes are regulated and the consequences thereof are largely unknown. Optic atrophy 1 (OPA1) is the mitochondrial GTPase responsible for inner membr... | OPA1-dependent cristae modulation is essential for cellular adaptation to metabolic demand. |
{"1014": 0.29109421372413635, "1052": 0.5838727951049805, "1999": 0.3824150264263153, "2005": 0.5092619061470032, "2007": 0.12556517124176025, "2034": 0.3318578004837036, "2044": 0.1889725625514984, "2053": 0.3012613356113434, "2064": 0.0770333781838417, "2077": 0.12814582884311676, "2086": 0.08782484382390976, "2090":... | 37619697 | BACKGROUND Phenylpropanolamine is commonly found in appetite suppressants and cough or cold remedies. Case reports have linked the use of products containing phenylpropanolamine to hemorrhagic stroke, often after the first use of these products. To study the association, we designed a case-control study. METHODS Men an... | Phenylpropanolamine and the risk of hemorrhagic stroke. |
{"1041": 0.24325250089168549, "1042": 0.29328158497810364, "1043": 0.14602625370025635, "1044": 0.07793712615966797, "2000": 0.03831886500120163, "2003": 0.1905880719423294, "2005": 0.4067663550376892, "2007": 0.08064348995685577, "2044": 0.22937409579753876, "2063": 1.3745063543319702, "2076": 0.08513788133859634, "20... | 37628989 | BACKGROUND Confocal laser endomicroscopy (CLE) is rapidly emerging as a valuable tool for gastrointestinal endoscopic imaging. Fluorescent contrast agents are used to optimize imaging with CLE, and intravenous fluorescein is the most widely used contrast agent. Fluorescein is FDA-cleared for diagnostic angiography of t... | The safety of intravenous fluorescein for confocal laser endomicroscopy in the gastrointestinal tract. |
{"1011": 0.18329764902591705, "1017": 0.17267228662967682, "1037": 0.034552380442619324, "1049": 0.5517725944519043, "2001": 0.0317181795835495, "2003": 0.3325583338737488, "2013": 0.43875885009765625, "2024": 0.015504186972975731, "2041": 0.1332872211933136, "2060": 0.2852376699447632, "2075": 0.083342544734478, "2084... | 37641175 | A DNA fraction is spontaneously released from living, but not dead or dying, human, other mammalian, avian, amphibian, plant, and prokaryote cells. The spontaneously released DNA fraction has been shown to be (a) present in both actively dividing and nondividing, differentiated cell populations; (b) labile; (c) associa... | Metabolic DNA as the origin of spontaneously released DNA? |
{"1011": 0.2501201331615448, "1041": 0.46363574266433716, "1043": 0.42735910415649414, "1996": 0.12814582884311676, "1997": 0.2089812457561493, "1999": 0.11430477350950241, "2003": 0.0058422754518687725, "2011": 0.25995752215385437, "2029": 0.129004567861557, "2043": 0.20977331697940826, "2046": 0.5925496220588684, "20... | 37643601 | Many viruses go through a maturation step in the final stages of assembly before being transmitted to another host. The maturation process of flaviviruses is directed by the proteolytic cleavage of the precursor membrane protein (prM), turning inert virus into infectious particles. We have determined the 2.2 angstrom r... | The flavivirus precursor membrane-envelope protein complex: structure and maturation. |
{"1011": 0.5685047507286072, "1043": 1.1888195276260376, "1157": 0.04953393340110779, "1996": 0.08692999184131622, "1999": 0.1510767638683319, "2003": 0.1011524572968483, "2008": 0.1358480453491211, "2015": 0.5139457583427429, "2019": 0.3877306580543518, "2024": 0.2976420819759369, "2029": 0.1889725625514984, "2060": 0... | 37673301 | G-protein coupled receptors (GPCRs) represent a large class of cell surface receptors that mediate a multitude of functions. Over the years, a number of GPCRs and ancillary proteins have been shown to be expressed in skeletal muscle. Unlike the case with other muscle tissues like cardiac and vascular smooth muscle cell... | Peptide and non-peptide G-protein coupled receptors (GPCRs) in skeletal muscle. |
{"1038": 0.11778303235769272, "1043": 0.7389566898345947, "1052": 0.7473171949386597, "1997": 0.22782009840011597, "2001": 0.11517547070980072, "2006": 0.08871890604496002, "2007": 0.009718249551951885, "2013": 0.4574742913246155, "2015": 0.08782484382390976, "2023": 0.1619328260421753, "2029": 0.1619328260421753, "203... | 37677954 | A new badnavirus was discovered from pagoda trees showing yellow mosaic symptoms on the leaves by high throughput sequencing of small RNAs. The complete genome of this virus was determined to comprise 7424 nucleotides, and the virus shared 40.4-45.1% identity with that of other badnaviruses. The genome encodes five ope... | Characterization of complete genome and small RNA profile of pagoda yellow mosaic associated virus, a novel badnavirus in China. |
{"1043": 1.013020396232605, "2000": 0.1734936386346817, "2003": 0.1808556467294693, "2005": 0.42353010177612305, "2007": 0.1751343309879303, "2024": 0.2852376699447632, "2029": 0.08244366943836212, "2033": 0.32270604372024536, "2041": 0.025073638185858727, "2042": 0.15275461971759796, "2045": 0.2478361576795578, "2051"... | 37686718 | Malignant gliomas, which include glioblastomas and anaplastic astrocytomas, are the most common primary tumors of the brain. Over the past 30 years, the standard treatment for these tumors has evolved to include maximal safe surgical resection, radiation therapy and temozolomide chemotherapy. While the median survival ... | Experimental approaches for the treatment of malignant gliomas. |
{"1011": 0.4286321699619293, "1015": 0.9754437208175659, "1038": 0.10731173306703568, "1039": 0.5472630262374878, "1040": 0.083342544734478, "1042": 1.004473328590393, "1043": 0.5947071313858032, "1045": 0.22392450273036957, "1052": 0.22782009840011597, "1156": 0.40285754203796387, "2000": 0.043007105588912964, "2003":... | 37699461 | Beta-cell replacement is considered to be the most promising approach for treatment of type 1 diabetes. Its application on a large scale is hindered by a shortage of cells for transplantation. Activation of insulin expression, storage, and regulated secretion in stem/progenitor cells offers novel ways to overcome this ... | Reversal of hyperglycemia in mice by using human expandable insulin-producing cells differentiated from fetal liver progenitor cells. |
{"1011": 0.1602703034877777, "2000": 0.15777134895324707, "2005": 0.3177432417869568, "2007": 0.043007105588912964, "2013": 0.28670501708984375, "2015": 0.4654768109321594, "2046": 0.12038381397724152, "2052": 0.1718502640724182, "2061": 0.8925741910934448, "2064": 0.4794800877571106, "2067": 0.05417001247406006, "2071... | 37722384 | The ability to reprogram somatic cells to induced pluripotent stem cells (iPSCs) offers an opportunity to generate pluripotent patient-specific cell lines that can help model human diseases. These iPSC lines could also be powerful tools for drug discovery and the development of cellular transplantation therapies. Many ... | A review of the methods for human iPSC derivation. |
{"1011": 0.3897167444229126, "1015": 0.011650617234408855, "1017": 0.23092569410800934, "1038": 0.6911921501159668, "1041": 1.2471669912338257, "1045": 0.5180262327194214, "1048": 0.2231435477733612, "1050": 0.53589928150177, "1999": 0.10906458646059036, "2003": 0.0354953333735466, "2004": 0.10818854719400406, "2007": ... | 37727521 | Epstein-Barr virus (EBV)-encoded small RNAs (EBERs) are nonpolyadenylated, untranslated RNAs, exist most abundantly in latently EBV-infected cells, and are expected to show secondary structures with many short stem-loops. Retinoic acid-inducible gene I (RIG-I) is a cytosolic protein that detects viral double-stranded R... | EB virus-encoded RNAs are recognized by RIG-I and activate signaling to induce type I IFN. |
{"1003": 0.06612417846918106, "1039": 0.18654440343379974, "1040": 0.33115679025650024, "1999": 0.10731173306703568, "2001": 0.19220098853111267, "2006": 0.6000806093215942, "2018": 0.05694137513637543, "2019": 0.2711893916130066, "2043": 0.1905880719423294, "2051": 0.10906458646059036, "2064": 0.16110190749168396, "20... | 37731372 | Although uncommon, pregnancy occurs in women on chronic dialysis. In 1980 the incidence of pregnancy in women on dialysis was 0.9%. Studies from 1992 to 2003 indicate that pregnancy occurred in 1-7% of women on chronic dialysis. Half of the infants born to women on chronic dialysis survive. Of importance is that "inten... | Pregnancy in dialysis patients: a review of outcomes, complications, and management. |
{"1011": 0.2184450328350067, "1039": 0.47402387857437134, "1043": 0.16276304423809052, "1044": 0.4462870955467224, "1045": 0.15359249711036682, "1049": 0.9052929878234863, "1052": 0.3443928062915802, "1058": 0.4267219603061676, "2003": 0.026976587250828743, "2005": 0.012615402229130268, "2007": 0.2160874605178833, "201... | 37762357 | Cytomegalovirus (CMV) has highly evolved mechanisms for avoiding detection by the host immune system. Recently, in the genomes of human and primate CMV, a novel gene comprising segments of noncontiguous open reading frames was identified and found to have limited predicted homology to endogenous cellular interleukin-10... | Potent immunosuppressive activities of cytomegalovirus-encoded interleukin-10. |
{"1011": 0.319873183965683, "1038": 0.17267228662967682, "1046": 0.052318159490823746, "1047": 0.5450005531311035, "1054": 0.16359257698059082, "1057": 0.2089812457561493, "1061": 0.1229778528213501, "1997": 0.0752234235405922, "1999": 0.13157635927200317, "2005": 0.18573370575904846, "2007": 0.27712854743003845, "2008... | 37768883 | In vivo activation of Klebsiella aerogenes urease, a nickel-containing enzyme, requires the presence of functional UreD, UreF, and UreG accessory proteins and is further facilitated by UreE. These accessory proteins are proposed to be involved in metallocenter assembly (M. H. Lee, S. B. Mulrooney, M. J. Renner, Y. Mark... | Evidence for the presence of urease apoprotein complexes containing UreD, UreF, and UreG in cells that are competent for in vivo enzyme activation. |
{"1011": 0.15275461971759796, "1055": 0.23015019297599792, "2003": 0.014542185701429844, "2005": 0.19782574474811554, "2007": 0.1510767638683319, "2011": 0.13499516248703003, "2013": 0.09495500475168228, "2029": 0.21372433006763458, "2046": 0.007782140281051397, "2061": 0.9531047344207764, "2064": 0.13414156436920166, ... | 37822406 | Derivation of patient-specific human pluripotent stem cells via somatic cell nuclear transfer (SCNT) has the potential for applications in a range of therapeutic contexts. However, successful SCNT with human cells has proved challenging to achieve, and thus far has only been reported with fetal or infant somatic cells.... | Human somatic cell nuclear transfer using adult cells. |
{"1011": 0.0317181795835495, "1048": 0.9680526852607727, "1052": 0.5640701055526733, "1999": 0.03831886500120163, "2005": 0.022212404757738113, "2008": 0.03831886500120163, "2011": 0.004870930220931768, "2013": 0.0009760859538801014, "2020": 0.0019512200960889459, "2029": 0.21135559678077698, "2035": 0.5324648022651672... | 37895688 | In the spleens of young, adult mice there exist naturally occurring killer lymphocytes with specificity for mouse Moloney leukemia cells. The lytic activity was directed against syngeneic or allogeneic Moloney leukemia cells to a similar extent, but was primarily expressed when tested against in vitro grown leukemia ce... | "Natural" killer cells in the mouse. I. Cytotoxic cells with specificity for mouse Moloney leukemia cells. Specificity and distribution according to genotype. |
{"1011": 0.22937409579753876, "1020": 0.14686977863311768, "1041": 0.009718249551951885, "1043": 0.6980181336402893, "1044": 0.2447827309370041, "1056": 0.01934296265244484, "2000": 0.18167030811309814, "2007": 0.1913948506116867, "2012": 0.3070250153541565, "2022": 0.15610189735889435, "2034": 0.32905077934265137, "20... | 37912677 | With the acknowledged problems associated with assessment of functioning thyroid mass and hence radiation dose, our policy had been to give 75 MBq iodine-131 at 6-monthly intervals to patients with Graves' disease until they became euthyroid. Since positron emission tomography (PET) has been available at this hospital,... | Dose-response study on thyrotoxic patients undergoing positron emission tomography and radioiodine therapy |
{"1014": 0.18492233753204346, "1039": 0.11256109178066254, "1047": 0.010684899985790253, "1052": 0.2470736801624298, "1053": 0.175953671336174, "1999": 0.22001366317272186, "2005": 0.030771657824516296, "2007": 0.21687394380569458, "2029": 0.04207121208310127, "2043": 0.056018441915512085, "2044": 0.02316705882549286, ... | 37916361 | OBJECTIVE The study of soluble corin in the circulation before hypertensive disorders of pregnancy (HDP) has been limited. Here we aimed to study serum soluble corin in mid pregnancy in patients with HDP and their age- and gestational weeks-matched controls. METHODS Sixty-eight pairs of cases of HDP and controls were s... | Increased serum soluble corin in mid pregnancy is associated with hypertensive disorders of pregnancy. |
{"1039": 0.25088030099868774, "1040": 0.009718249551951885, "1999": 0.2247048318386078, "2003": 0.037378571927547455, "2005": 0.5573811531066895, "2038": 0.1011524572968483, "2042": 0.0009760859538801014, "2079": 0.1477125883102417, "2109": 0.6793810129165649, "2147": 0.11168810725212097, "2204": 0.21922965347766876, "... | 37949139 | Dandelions have long been used in herbal medicine for their choleretic, diuretic, antiinflammatory, appetite-stimulating and laxative properties. An antioxidant property can be supposed as a basis of their-therapeutic effects. To understand the mechanism of the drug's action, the effects of natural extracts on a micros... | The in vitro effect of dandelions antioxidants on microsomal lipid peroxidation. |
{"1009": 0.8517522215843201, "1014": 0.0354953333735466, "1016": 0.09317722171545029, "1039": 0.7314660549163818, "1996": 0.011650617234408855, "1999": 0.0317181795835495, "2007": 0.02412080205976963, "2011": 0.3325583338737488, "2013": 0.06703783571720123, "2020": 0.034552380442619324, "2029": 0.22859740257263184, "20... | 37964706 | Ca2+ entry through store-operated Ca2+ channels drives the production of the pro-inflammatory molecule leukotriene C4 (LTC4) from mast cells through a pathway involving Ca2+-dependent protein kinase C, mitogen-activated protein kinases ERK1/2, phospholipase A2, and 5-lipoxygenase. Here we examine whether local Ca2+ inf... | Local Ca2+ influx through Ca2+ release-activated Ca2+ (CRAC) channels stimulates production of an intracellular messenger and an intercellular pro-inflammatory signal. |
{"1018": 0.1905880719423294, "1048": 0.27564704418182373, "1055": 0.7028654217720032, "1056": 0.4914994537830353, "1999": 0.07159364968538284, "2004": 0.14095009863376617, "2005": 0.11951763927936554, "2007": 0.6086184978485107, "2008": 0.04674193635582924, "2011": 0.021256839856505394, "2012": 0.6872705817222595, "202... | 37969403 | New recombinant strains of attenuated Salmonella typhi used as live oral vaccines elicit potent immune responses. This study examined the patterns of cytokine production and proliferation to specific S. typhi antigens in subjects orally immunized with attenuated S. typhi vaccines CVD 906, CVD 908, and CVD 908 expressin... | Cytokine production patterns and lymphoproliferative responses in volunteers orally immunized with attenuated vaccine strains of Salmonella typhi. |
{"1017": 0.2837681770324707, "1018": 0.53589928150177, "1021": 0.5871354341506958, "1044": 0.33605360984802246, "1048": 0.3070250153541565, "1997": 0.03925827145576477, "2004": 0.29619070887565613, "2005": 0.09050461649894714, "2010": 0.7537717819213867, "2011": 0.43875885009765625, "2012": 0.2160874605178833, "2019": ... | 38009906 | Expression of the INK4b/ARF/INK4a tumor suppressor locus in normal and cancerous cell growth is controlled by methylation of histone H3 at lysine 27 (H3K27me) as directed by the Polycomb group proteins. The antisense noncoding RNA ANRIL of the INK4b/ARF/INK4a locus is also important for expression of the protein-coding... | Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a. |
{"1011": 0.306306391954422, "1013": 0.23710809648036957, "1042": 0.15693697333335876, "1052": 0.38308101892471313, "2012": 0.5313173532485962, "2029": 0.2089812457561493, "2048": 0.19220098853111267, "2058": 0.14686977863311768, "2080": 0.0019512200960889459, "2135": 0.4093637466430664, "2179": 0.1905880719423294, "230... | 38023457 | Severe quantitative and qualitative brown adipocyte defects are common in obesity. To investigate whether aberrant expression of tumor necrosis factor alpha (TNF-alpha) in obesity is involved in functional brown fat atrophy, we have studied genetically obese (ob/ob) mice with targeted null mutations in the genes encodi... | Tumor necrosis factor alpha mediates apoptosis of brown adipocytes and defective brown adipocyte function in obesity. |
{"1042": 0.574020504951477, "1049": 0.3662964701652527, "2002": 0.7881022095680237, "2003": 0.2674594223499298, "2004": 0.1685553640127182, "2005": 0.12642613053321838, "2007": 0.10203468054533005, "2010": 0.5685047507286072, "2053": 0.2786078155040741, "2092": 0.1485546976327896, "2094": 0.9115922451019287, "2140": 0.... | 38025907 | Nonalcoholic fatty liver disease (NAFLD) is an increasingly prevalent chronic liver disease for which no approved therapies are available. Despite intensive research, the cellular mechanisms that mediate NAFLD pathogenesis and progression are poorly understood. Although obesity, diabetes, insulin resistance, and relate... | Engineered FGF19 eliminates bile acid toxicity and lipotoxicity leading to resolution of steatohepatitis and fibrosis in mice |
{"1018": 0.015504186972975731, "1022": 0.22937409579753876, "1040": 0.06246116757392883, "1156": 0.08782484382390976, "2002": 0.6128603219985962, "2007": 0.07431721687316895, "2011": 0.0058422754518687725, "2012": 0.07341018319129944, "2029": 0.11430477350950241, "2033": 0.3127557039260864, "2034": 0.06703783571720123,... | 38028419 | White adipose tissue (WAT) secretes adipokines, which critically regulate lipid metabolism. The present study investigated the effects of alcohol on adipokines and the mechanistic link between adipokine dysregulation and alcoholic fatty liver disease. Mice were fed alcohol for 2, 4, or 8 weeks to document changes in ad... | Leptin deficiency contributes to the pathogenesis of alcoholic fatty liver disease in mice. |
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