spalde-v3-lexical stringlengths 4.95k 41.3k | _id stringlengths 4 9 | text stringlengths 174 10k | title stringlengths 2 300 |
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{"1011": 0.08064348995685577, "1014": 0.6441128253936768, "1047": 0.3443928062915802, "1050": 0.07612881064414978, "1055": 0.21530038118362427, "1164": 0.36494144797325134, "2001": 0.04394211992621422, "2005": 0.17267228662967682, "2034": 0.3070250153541565, "2038": 0.08603433519601822, "2041": 0.23092569410800934, "20... | 43647194 | The availability of valid migraine-specific questionnaires is important when large numbers of migraine patients have to be analysed. The Finnish Migraine-Specific Questionnaire has been validated in two stages. In the first, a clinical diagnosis of migraine was reached, using International Headache Society criteria, in... | Validation of a migraine-specific questionnaire for use in family studies. |
{"1011": 0.39762192964553833, "1013": 0.38308101892471313, "1017": 0.1510767638683319, "1038": 0.7827593088150024, "1052": 0.4002431631088257, "1059": 1.1530905961990356, "1156": 0.4248080551624298, "1996": 0.13157635927200317, "1998": 0.053244512528181076, "2002": 0.9958525896072388, "2011": 0.3883931338787079, "2015"... | 43661837 | The canonical Wnt/beta-catenin signaling has remarkably diverse roles in embryonic development, stem cell self-renewal and cancer progression. Here, we show that stabilized expression of beta-catenin perturbed human embryonic stem (hES)-cell self-renewal, such that up to 80% of the hES cells developed into the primitiv... | Defining early lineage specification of human embryonic stem cells by the orchestrated balance of canonical Wnt/beta-catenin, Activin/Nodal and BMP signaling. |
{"1011": 0.1710275560617447, "1015": 0.3012613356113434, "1019": 0.40351006388664246, "1022": 0.5415972471237183, "1039": 0.036437395960092545, "1043": 0.39696553349494934, "1047": 0.5427330136299133, "1055": 0.839173436164856, "1999": 0.42353010177612305, "2004": 0.11778303235769272, "2007": 0.3683255612850189, "2011"... | 43700577 | Consistent with previous reports, sphingosine at a high concentration (5 microM) was cardiotoxic as evidenced by increased infarct size in response to ischemia/reperfusion in an ex vivo rat heart. Sphingosine 1-phosphate (S1P) at 5 microM was cardioprotective. However, at a physiologic concentration (0.4 microM) sphing... | Sphingosine can pre- and post-condition heart and utilizes a different mechanism from sphingosine 1-phosphate. |
{"1011": 0.47463157773017883, "1052": 0.7172679901123047, "1999": 0.11951763927936554, "2007": 0.49686139822006226, "2008": 0.2531573474407196, "2010": 0.46363574266433716, "2011": 0.4654768109321594, "2029": 0.49864232540130615, "2075": 0.06337817758321762, "2076": 0.304147332906723, "2083": 0.06886265426874161, "2098... | 43711341 | Transcriptional coactivators showing physical and functional interactions with PPARgamma include the protein acetyl transferase p300, the TRAP/Mediator complex that interacts with the general transcription machinery, and the highly regulated PGC-1alpha. We show that PGC-1alpha directly interacts with TRAP/Mediator, thr... | Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1alpha. |
{"1011": 0.2409527748823166, "1017": 0.1510767638683319, "1043": 0.47827014327049255, "1050": 0.2719337046146393, "1996": 0.1808556467294693, "1997": 0.2516399025917053, "1999": 0.29255300760269165, "2011": 0.13243216276168823, "2013": 0.11081436276435852, "2019": 0.37640097737312317, "2020": 0.15442965924739838, "2024... | 43752562 | Subcellular membranes of Saccharomyces cerevisiae, including mitochondria, microsomes, plasma membranes, secretory vesicles, vacuoles, nuclear membranes, peroxisomes, and lipid particles, were isolated by improved procedures and analyzed for their lipid composition and their capacity to synthesize phospholipids and to ... | Phospholipid synthesis and lipid composition of subcellular membranes in the unicellular eukaryote Saccharomyces cerevisiae. |
{"1015": 0.05046287178993225, "1037": 0.06795065850019455, "1998": 0.42735910415649414, "1999": 0.5500838756561279, "2000": 0.09317722171545029, "2003": 0.009718249551951885, "2004": 0.0058422754518687725, "2005": 0.259204238653183, "2007": 0.20501139760017395, "2012": 0.06977381557226181, "2015": 0.06154331564903259, ... | 43855756 | The future organisation of prison health care 1 recommends that the NHS and the Prison Service work together to plan and provide health care services for prisoners. Whereas previously the Prison Service had this responsibility alone. The NHS will therefore have to take stock of the current level at which prison health ... | Use of health services by prison inmates: comparisons with the community. |
{"1052": 1.0815403461456299, "2006": 0.1384023278951645, "2011": 0.15860503911972046, "2012": 0.26146242022514343, "2015": 0.05786345899105072, "2029": 0.1808556467294693, "2043": 0.10467668622732162, "2049": 0.021256839856505394, "2064": 0.10993985831737518, "2076": 0.2145126610994339, "2079": 0.09050461649894714, "20... | 43880096 | Activation of p53 can occur in response to a number of cellular stresses, including DNA damage, hypoxia and nucleotide deprivation. Several forms of DNA damage have been shown to activate p53, including those generated by ionising radiation (IR), radio-mimetic drugs, ultraviolet light (UV) and chemicals such as methyl ... | Regulation of p53 in response to DNA damage |
{"1006": 0.1229778528213501, "1009": 0.43434104323387146, "1011": 0.20977331697940826, "1016": 0.4831010699272156, "1019": 0.13925230503082275, "1041": 0.48970574140548706, "1044": 0.8161250352859497, "1045": 0.1064341589808464, "1050": 0.08064348995685577, "1055": 0.6603899002075195, "1997": 0.0752234235405922, "1999"... | 43890638 | We investigated the role of hydrogen sulphide (H(2)S) in intracellular pH (pH(i)) regulation in vascular smooth muscle cells and its contribution on vasodilation. NaHS, a H(2)S donor, decreased pH(i) in a concentration-dependent manner ranging from 10 microM to 1mM. Neither inhibition of the Na(+)/H(+) exchanger with 5... | Hydrogen sulphide regulates intracellular pH in vascular smooth muscle cells. |
{"2003": 0.05970508232712746, "2005": 0.009718249551951885, "2015": 0.05139094591140747, "2033": 0.5174443125724792, "2054": 0.09406650811433792, "2064": 0.21135559678077698, "2075": 0.058784693479537964, "2079": 0.22157983481884003, "2109": 0.10906458646059036, "2117": 0.052318159490823746, "2129": 0.05694137513637543... | 43990286 | Tissue engineering frequently involves cells and scaffolds to replace damaged or diseased tissue. It originated, in part, as a means of effecting the delivery of biomolecules such as insulin or neurotrophic factors, given that cells are constitutive producers of such therapeutic agents. Thus cell delivery is intrinsic ... | Cell and biomolecule delivery for tissue repair and regeneration in the central nervous system. |
{"1011": 0.040196798741817474, "1013": 0.31132611632347107, "1014": 0.1710275560617447, "1015": 0.11951763927936554, "1037": 0.25239890813827515, "1038": 0.6107416749000549, "1043": 0.5506471395492554, "1044": 0.42926809191703796, "1052": 0.49030399322509766, "2006": 0.5629584193229675, "2007": 0.23556606471538544, "20... | 44030361 | Accumulated evidence suggests that an altered ambulatory blood pressure (BP) profile, particularly elevated nighttime BP, reflects target organ injury and is a better predictor of further cardiorenal risk than the clinic BP or daytime BP in hypertensive patients complicated by chronic kidney disease (CKD). In this stud... | The angiotensin II type 1 receptor blocker olmesartan preferentially improves nocturnal hypertension and proteinuria in chronic kidney disease |
{"1014": 0.2990913391113281, "1052": 0.5483922958374023, "2001": 0.06703783571720123, "2007": 0.07612881064414978, "2030": 0.0038986403960734606, "2041": 0.16524957120418549, "2051": 0.36290550231933594, "2053": 0.04113444685935974, "2067": 0.0058422754518687725, "2086": 0.500420093536377, "2095": 0.05139094591140747, ... | 44048701 | IMPORTANCE The need for surgery for the majority of patients with displaced proximal humeral fractures is unclear, but its use is increasing. OBJECTIVE To evaluate the clinical effectiveness of surgical vs nonsurgical treatment for adults with displaced fractures of the proximal humerus involving the surgical neck. DES... | Surgical vs nonsurgical treatment of adults with displaced fractures of the proximal humerus: the PROFHER randomized clinical trial. |
{"1011": 0.151916041970253, "1023": 0.8247235417366028, "1038": 0.0770333781838417, "2003": 0.32270604372024536, "2005": 0.08513788133859634, "2011": 0.10026945173740387, "2015": 0.28597161173820496, "2029": 0.004870930220931768, "2044": 0.3297532796859741, "2051": 0.4349733293056488, "2058": 0.013579257763922215, "206... | 44172171 | The RNA-guided DNA endonuclease Cas9 is a powerful tool for genome editing. Little is known about the kinetics and fidelity of the double-strand break (DSB) repair process that follows a Cas9 cutting event in living cells. Here, we developed a strategy to measure the kinetics of DSB repair for single loci in human cell... | Kinetics and Fidelity of the Repair of Cas9-Induced Double-Strand DNA Breaks |
{"1011": 0.3381449282169342, "1016": 0.08154398202896118, "1049": 0.06977381557226181, "1998": 0.20421554148197174, "1999": 0.02887592278420925, "2005": 0.006812678650021553, "2025": 0.25239890813827515, "2026": 0.5472630262374878, "2029": 0.03360854089260101, "2033": 0.056018441915512085, "2048": 0.7105726003646851, "... | 44264297 | I present methods for assessing the relative effectiveness of two treatments when they have not been compared directly in a randomized trial but have each been compared to other treatments. These network meta-analysis techniques allow estimation of both heterogeneity in the effect of any given treatment and inconsisten... | Network meta-analysis for indirect treatment comparisons. |
{"1003": 0.12556517124176025, "1039": 0.6522845029830933, "1048": 0.23556606471538544, "1057": 0.4462870955467224, "2002": 0.8715548515319824, "2005": 0.10555581003427505, "2007": 0.0842406153678894, "2010": 0.19220098853111267, "2013": 0.06886265426874161, "2015": 0.5051454305648804, "2019": 0.2652147710323334, "2025"... | 44265107 | ContextChronic hepatitis C is the leading cause for liver transplantation in the United States. Intravenous drug use, the major risk factor, accounts for approximately 60% of hepatitis C virus transmission. Information from the United Network of Organ Sharing (UNOS) does not address substance use among liver transplant... | Liver transplantation and opioid dependence. |
{"1011": 0.4400174915790558, "1019": 0.18329764902591705, "1037": 0.6674286723136902, "1040": 0.04860413447022438, "1045": 0.5133614540100098, "1056": 0.0770333781838417, "2002": 0.6773988008499146, "2003": 0.04394211992621422, "2005": 0.21293537318706512, "2008": 0.05694137513637543, "2011": 0.3963087201118469, "2025"... | 44366096 | Double-stranded RNA (dsRNA) produced during viral replication is believed to be the critical trigger for activation of antiviral immunity mediated by the RNA helicase enzymes retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated gene 5 (MDA5). We showed that influenza A virus infection does not... | RIG-I-mediated antiviral responses to single-stranded RNA bearing 5'-phosphates. |
{"1003": 0.034552380442619324, "1014": 0.025073638185858727, "1018": 0.09406650811433792, "1051": 0.13157635927200317, "1052": 0.12556517124176025, "1056": 0.058784693479537964, "1999": 0.4311734735965729, "2000": 0.1677299439907074, "2006": 0.19622190296649933, "2007": 0.42608439922332764, "2025": 0.1485546976327896, ... | 44384384 | AIMS While randomized clinical trials have compared clopidogrel with higher potency adenosine diphosphate (ADP) receptor inhibitors among patients with acute myocardial infarction, little is known about the frequency, effectiveness and safety of switching between ADP receptor inhibitors in routine clinical practice. ME... | In-hospital switching between adenosine diphosphate receptor inhibitors in patients with acute myocardial infarction treated with percutaneous coronary intervention: Insights into contemporary practice from the TRANSLATE-ACS study. |
{"1043": 0.5318912267684937, "1044": 0.3810817003250122, "2004": 0.7426811456680298, "2011": 0.11604541540145874, "2012": 0.66441810131073, "2089": 0.28963330388069153, "2090": 0.04113444685935974, "2110": 0.3325583338737488, "2135": 0.672426164150238, "2152": 0.33953672647476196, "2163": 0.10906458646059036, "2203": 0... | 44387884 | The abnormal metabolic state that accompanies diabetes renders arteries susceptible to atherosclerosis, being capable of altering the functional properties of multiple cell types, including endothelium and platelets. In particular, an altered platelet metabolism and changes in intraplatelet signaling pathways may contr... | Platelet activation in type 2 diabetes mellitus. |
{"1011": 0.13755162060260773, "1016": 0.15442965924739838, "1017": 0.26296505331993103, "1021": 0.22937409579753876, "1043": 0.259204238653183, "1060": 0.6659244894981384, "2005": 0.1477125883102417, "2011": 0.35813871026039124, "2013": 0.083342544734478, "2029": 0.23092569410800934, "2039": 0.6059582233428955, "2053":... | 44408494 | Multiple lines of evidence, from molecular and cellular to epidemiological, have implicated nicotinic transmission in the pathology of Alzheimer's disease (AD) and Parkinson's disease (PD). This review article presents evidence for nicotinic acetylcholine receptor (nAChR)-mediated protection and the signal transduction... | Nicotinic receptor-mediated neuroprotection in neurodegenerative disease models. |
{"1015": 0.0009760859538801014, "1020": 0.5232481360435486, "1023": 0.43244171142578125, "1043": 0.02792670577764511, "1050": 0.07159364968538284, "2000": 0.23710809648036957, "2003": 0.12986256182193756, "2005": 0.0354953333735466, "2007": 0.1332872211933136, "2015": 0.09317722171545029, "2047": 0.43244171142578125, "... | 44409062 | In recent years, a new paradigm for genome annotation has emerged, termed "proteogenomics," that leverages peptide MS to annotate a genome. This is achieved by mapping peptides to a six-frame translation of a genome, including available splice databases, which may suggest refinements to gene models. Using this approach... | High-throughput parallel proteogenomics: a bacterial case study. |
{"1011": 0.20501139760017395, "1043": 0.2231435477733612, "1056": 0.20501139760017395, "1996": 0.056018441915512085, "1997": 0.053244512528181076, "1999": 0.2539152204990387, "2003": 0.045809537172317505, "2004": 0.02412080205976963, "2005": 0.056018441915512085, "2007": 0.1889725625514984, "2008": 0.20739519596099854,... | 44420873 | The predominant form of the cross-linking enzyme, transglutaminase, in cultured normal human epidermal keratinocytes, is found in cell particulate material and can be solubilized by nonionic detergent. It elutes as a single peak upon either anion-exchange or gel-filtration chromatography. Monoclonal antibodies raised t... | Keratinocyte-specific transglutaminase of cultured human epidermal cells: relation to cross-linked envelope formation and terminal differentiation. |
{"1011": 0.14433705806732178, "1014": 0.14095009863376617, "1015": 0.30558720231056213, "2004": 0.029824240133166313, "2007": 0.08871890604496002, "2020": 0.1064341589808464, "2028": 0.04394211992621422, "2029": 0.2852376699447632, "2034": 0.2447827309370041, "2038": 0.20977331697940826, "2042": 0.1751343309879303, "20... | 44500794 | The aim of this study was to compare the effects of the genetic and pharmacological disruption of CB1 cannabinoid receptors on the elevated plus-maze test of anxiety. In the first experiment, the behaviour of CB1-knockout mice and wild-type mice was compared. In the second experiment, the cannabinoid antagonist SR14171... | The effects of genetic and pharmacological blockade of the CB1 cannabinoid receptor on anxiety. |
{"1998": 0.35403475165367126, "2047": 0.1011524572968483, "2061": 0.006812678650021553, "2071": 0.175953671336174, "2076": 0.3757305145263672, "2079": 0.09584271162748337, "2089": 0.014542185701429844, "2090": 0.3304552733898163, "2119": 0.39893341064453125, "2129": 0.12642613053321838, "2146": 0.15693697333335876, "21... | 44562058 | Despite complete or near-complete suppression of human immunodeficiency virus (HIV) replication with combination antiretroviral therapy, both HIV and chronic inflammation/immune dysfunction persist indefinitely. Untangling the association between the virus and the host immune environment during therapy might lead to no... | Immune activation and HIV persistence: implications for curative approaches to HIV infection. |
{"1009": 0.28450319170951843, "1011": 0.11081436276435852, "1020": 0.015504186972975731, "1039": 0.0317181795835495, "1043": 1.207676887512207, "2015": 0.41065993905067444, "2020": 0.11430477350950241, "2026": 0.6734226942062378, "2029": 0.0842406153678894, "2044": 0.2394166737794876, "2058": 0.23787821829319, "2064": ... | 44562221 | Endogenous glucocorticoids (GC) play an important role in the termination of the inflammatory response following infection and tissue injury. However, recent findings indicate that stress can impair the anti-inflammatory capacities of these hormones. Lipopolysaccharide (LPS)-stimulated splenocytes of mice that were rep... | Tissue-specific alterations in the glucocorticoid sensitivity of immune cells following repeated social defeat in mice |
{"1014": 0.2786078155040741, "1017": 0.06612417846918106, "1023": 0.06795065850019455, "1048": 0.013579257763922215, "1053": 0.09228714555501938, "2000": 0.1332872211933136, "2001": 0.07884006202220917, "2007": 0.3034266233444214, "2012": 0.029824240133166313, "2020": 0.13243216276168823, "2034": 0.32058215141296387, "... | 44562904 | BACKGROUND Many patients with lung cancer report delays in diagnosing their disease. This may contribute to advanced stage at diagnosis and poor long term survival. This study explores the delays experienced by patients referred to a regional cancer centre with lung cancer. METHODS A prospective cohort of patients refe... | Delays in the diagnosis of lung cancer. |
{"1015": 0.052318159490823746, "1040": 0.46486347913742065, "1051": 0.14686977863311768, "2000": 0.04113444685935974, "2005": 0.1751343309879303, "2007": 0.07612881064414978, "2011": 0.09406650811433792, "2012": 0.08244366943836212, "2022": 0.053244512528181076, "2043": 0.176772341132164, "2050": 0.3170322775840759, "2... | 44572913 | On the basis of previous epidemiological, clinical and experimental studies, it was demonstrated that adequate calcium intake during growth may influence peak bone mass/density, and may be instrumental in preventing subsequent postmenopausal and senile osteoporosis. Calcium intake during adolescence appears to affect s... | Calcium and peak bone mass. |
{"1022": 0.14264501631259918, "1999": 0.36426326632499695, "2005": 0.07159364968538284, "2007": 0.08064348995685577, "2025": 0.03831886500120163, "2064": 0.22626367211341858, "2079": 0.08513788133859634, "2109": 0.14939609169960022, "2111": 0.058784693479537964, "2113": 0.02792670577764511, "2116": 0.33953672647476196,... | 44586415 | QUESTION Do clinical tests accurately diagnose rotator cuff pathology? DESIGN A systematic review of investigations into the diagnostic accuracy of clinical tests for rotator cuff pathology. PARTICIPANTS People with shoulder pain who underwent clinical testing in order to diagnose rotator cuff pathology. OUTCOME MEASUR... | Most clinical tests cannot accurately diagnose rotator cuff pathology: a systematic review. |
{"1007": 0.083342544734478, "1011": 0.18978065252304077, "1014": 0.01934296265244484, "1019": 0.1011524572968483, "1020": 0.8332487344741821, "1041": 0.319873183965683, "1043": 0.30486753582954407, "1044": 0.40351006388664246, "1045": 0.40351006388664246, "1052": 0.2223619967699051, "1999": 0.09938567131757736, "2004":... | 44614949 | OBJECTIVE To investigate the role of skeletal muscle (SkM) interleukin (IL)-6 in the regulation of adipose tissue metabolism. METHODS Muscle-specific IL-6 knockout (IL-6 MKO) and IL-6(loxP/loxP) (Floxed) mice were subjected to standard rodent diet (Chow), high-fat diet (HFD), or HFD in combination with exercise trainin... | Skeletal muscle interleukin‐6 regulates metabolic factors in iWAT during HFD and exercise training |
{"1014": 0.37907835841178894, "1038": 0.5376120805740356, "1044": 0.3127557039260864, "1045": 0.8525851964950562, "2002": 0.040196798741817474, "2003": 0.0174254160374403, "2007": 0.009718249551951885, "2011": 0.1011524572968483, "2039": 0.23015019297599792, "2044": 0.38905516266822815, "2053": 0.052318159490823746, "2... | 44624045 | BACKGROUND Few previous prospective studies have examined differences in incident ischemic heart disease (IHD) risk between vegetarians and nonvegetarians. OBJECTIVE The objective was to examine the association of a vegetarian diet with risk of incident (nonfatal and fatal) IHD. DESIGN A total of 44,561 men and women l... | Risk of hospitalization or death from ischemic heart disease among British vegetarians and nonvegetarians: results from the EPIC-Oxford cohort study. |
{"1045": 0.03266380727291107, "1998": 0.037378571927547455, "2003": 0.24018502235412598, "2011": 0.5387523174285889, "2015": 0.29619070887565613, "2040": 0.2501201331615448, "2047": 0.08692999184131622, "2060": 0.021256839856505394, "2079": 0.2145126610994339, "2109": 0.0770333781838417, "2120": 0.7674643993377686, "21... | 44629665 | Multiple health priorities, limited human resources and logistical capacities, as well as expensive vaccines with limited funds available increase the need for evidence-based decision making in immunization programs. The aim of the Supporting Independent Immunization and Vaccine Advisory Committees (SIVAC) Initiative i... | The Supporting Independent Immunization and Vaccine Advisory Committees (SIVAC) initiative: a country-driven, multi-partner program to support evidence-based decision making. |
{"1011": 0.13755162060260773, "1041": 0.47584590315818787, "1155": 0.49923527240753174, "1156": 0.35334911942481995, "1996": 0.15693697333335876, "2011": 0.22548456490039825, "2015": 0.7182208299636841, "2029": 0.02887592278420925, "2075": 0.05139094591140747, "2076": 0.3897167444229126, "2079": 0.23556606471538544, "2... | 44640124 | SIGNIFICANCE The extracellular matrix (ECM) fulfills essential functions in multicellular organisms. It provides the mechanical scaffold and environmental cues to cells. Upon cell attachment, the ECM signals into the cells. In this process, reactive oxygen species (ROS) are physiologically used as signalizing molecules... | Redox-relevant aspects of the extracellular matrix and its cellular contacts via integrins. |
{"1003": 0.13499516248703003, "1014": 0.35334911942481995, "1018": 0.12556517124176025, "1020": 0.2990913391113281, "1022": 0.07250232994556427, "1023": 0.17020416259765625, "1044": 0.8829278349876404, "1052": 0.15359249711036682, "1998": 0.3070250153541565, "2001": 0.12556517124176025, "2004": 0.1685553640127182, "201... | 44660616 | OBJECTIVE To determine the prevalence of hypertension and pre-hypertension on the basis of the 2004 National High Blood Pressure Education Program Working Group guidelines in an adolescent school-screening population. STUDY DESIGN Cross-sectional assessment of blood pressure (BP) in 6790 adolescents (11-17 years) in Ho... | Prevalence of hypertension and pre-hypertension among adolescents. |
{"1050": 0.15777134895324707, "2001": 0.12986256182193756, "2007": 0.371698260307312, "2013": 0.004870930220931768, "2020": 0.12384103983640671, "2034": 0.6011518239974976, "2039": 0.25995752215385437, "2043": 0.045809537172317505, "2044": 0.1602703034877777, "2051": 0.4462870955467224, "2072": 0.053244512528181076, "2... | 44672703 | BACKGROUND & AIMS Various commensal enteric and potentially pathogenic bacteria may be involved in the pathogenesis of inflammatory bowel diseases (IBD). We compared the risk of IBD between a cohort of patients with documented Salmonella or Campylobacter gastroenteritis and an age- and gender-matched control group from... | Increased short- and long-term risk of inflammatory bowel disease after salmonella or campylobacter gastroenteritis. |
{"1013": 0.27934664487838745, "1017": 0.02316705882549286, "1022": 0.020300358533859253, "1038": 0.2247048318386078, "1039": 0.47158926725387573, "1041": 0.8459017872810364, "1052": 0.4002431631088257, "2001": 0.14939609169960022, "2007": 0.02887592278420925, "2010": 0.5278670787811279, "2012": 0.2990913391113281, "201... | 44674301 | A long-term cell culture epithelioid cell line was established from a recurrent squamous carcinoma of the nasopharynx of a Chinese male 17 1/2 years after radiation therapy. The cell line, designated NPC/HK1, has been passed 72 times over a period 1 year. The cells have been shown by light and electron microscopies to ... | Establishment of a cell line (NPC/HK1) from a differentiated squamous carcinoma of the nasopharynx. |
{"1003": 0.11691460013389587, "1021": 0.2026219218969345, "1052": 0.24171993136405945, "2015": 0.6471850275993347, "2029": 0.05970508232712746, "2044": 0.15526613593101501, "2064": 0.29981520771980286, "2071": 0.036437395960092545, "2076": 0.018384648486971855, "2079": 0.012615402229130268, "2084": 0.3353555500507355, ... | 44693226 | Many studies have shown that caloric restriction (40%) decreases mitochondrial reactive oxygen species (ROS) generation in rodents. Moreover, we have recently found that 7 weeks of 40% protein restriction without strong caloric restriction also decreases ROS production in rat liver. This is interesting since it has bee... | Effect of lipid restriction on mitochondrial free radical production and oxidative DNA damage. |
{"1009": 0.5197699069976807, "1011": 0.23324857652187347, "1016": 0.6916812658309937, "1047": 1.222740888595581, "1050": 0.10818854719400406, "1164": 0.5415972471237183, "2003": 0.1011524572968483, "2005": 0.1384023278951645, "2026": 0.9379299283027649, "2029": 0.15693697333335876, "2033": 0.2561853528022766, "2048": 0... | 44724517 | Although myeloid cell activation is requisite for an optimal innate immune response, this process must be tightly controlled to prevent collateral host tissue damage. Kruppel-like factor 2 (KLF2) is a potent regulator of myeloid cell proinflammatory activation. As an approximately 30% to 50% reduction in KLF2 levels ha... | Kruppel-like factor 2 is a transcriptional regulator of chronic and acute inflammation. |
{"1011": 0.04767346754670143, "1019": 0.15442965924739838, "1020": 0.10555581003427505, "1023": 0.06520967930555344, "1039": 0.5540198087692261, "1058": 0.630689799785614, "2007": 0.1946154683828354, "2020": 0.08154398202896118, "2029": 0.11256109178066254, "2043": 0.07159364968538284, "2044": 0.20580662786960602, "204... | 44737533 | METHODS To define potential common features of simian immunodeficiency virus (SIV) infections in different naturally infected host species, we compared the dynamics of viral replication in 31 African green monkeys (10 sabeus, 15 vervets and seven Caribbean AGMs), 14 mandrills and three sooty mangabeys (SMs) that were e... | Simian immunodeficiency viruses replication dynamics in African non-human primate hosts: common patterns and species-specific differences. |
{"1011": 0.304147332906723, "1016": 0.2622140049934387, "1047": 1.1798561811447144, "1062": 0.8187123537063599, "1996": 0.13157635927200317, "1999": 0.07431721687316895, "2004": 0.08961215615272522, "2005": 0.06886265426874161, "2008": 0.1332872211933136, "2011": 0.26296505331993103, "2029": 0.3877306580543518, "2046":... | 44801733 | The zinc-finger transcription factor KLF2 transduces the physical forces exerted by blood flow into molecular signals responsible for a wide range of biological responses. Following its initial recognition as a flow-responsive endothelial transcription factor, KLF2 is now known to be expressed in a range of cell types ... | The role of the transcription factor KLF2 in vascular development and disease. |
{"1016": 0.08692999184131622, "1020": 0.1913948506116867, "1022": 0.11343330889940262, "1052": 0.5984715819358826, "1609": 0.2501201331615448, "1999": 0.25239890813827515, "2001": 0.10291612148284912, "2004": 0.22079704701900482, "2005": 0.20102575421333313, "2006": 0.007782140281051397, "2007": 0.056018441915512085, "... | 44827480 | BACKGROUND Few data exist about the implementation of contemporary oral antiplatelet treatment guidelines in patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI). METHODS GReek AntiPlatelet rEgistry (GRAPE), initiated on January 2012, is a prospective, observational, multicent... | Implementation of contemporary oral antiplatelet treatment guidelines in patients with acute coronary syndrome undergoing percutaneous coronary intervention: a report from the GReek AntiPlatelet rEgistry (GRAPE). |
{"1003": 0.14518201351165771, "1040": 0.5051454305648804, "1052": 0.0317181795835495, "1998": 0.2881702482700348, "2007": 0.30917787551879883, "2012": 0.16524957120418549, "2062": 0.3012613356113434, "2086": 0.3381449282169342, "2095": 0.022212404757738113, "2111": 0.03266380727291107, "2116": 0.2089812457561493, "2119... | 44830890 | OBJECTIVE To investigate the frequency of depressive and anxiety disorders in patients with chronic daily headache. BACKGROUND There is a lack of data in the literature on the extent of psychiatric comorbidity in patients with different subtypes of chronic daily headache. METHODS We recruited consecutive patients with ... | Comorbidity of depressive and anxiety disorders in chronic daily headache and its subtypes. |
{"1011": 0.5336109399795532, "1015": 0.29473719000816345, "1020": 0.672426164150238, "1022": 0.5238267183303833, "1048": 0.09938567131757736, "1050": 0.46853771805763245, "1164": 0.013579257763922215, "1999": 0.15610189735889435, "2011": 0.32058215141296387, "2020": 0.02792670577764511, "2029": 0.18573370575904846, "20... | 44935041 | Although most cytokines are studied for biological effects after engagement of their specific cell surface membrane receptors, increasing evidence suggests that some function in the nucleus. In the present study, the precursor form of IL-1alpha was overexpressed in various cells and assessed for activity in the presenc... | The precursor form of IL-1alpha is an intracrine proinflammatory activator of transcription. |
{"1011": 0.2539152204990387, "1015": 0.40806588530540466, "1017": 0.04953393340110779, "1057": 0.9485763907432556, "1997": 0.2160874605178833, "1998": 0.0019512200960889459, "2011": 0.043007105588912964, "2013": 0.29036402702331543, "2028": 0.13499516248703003, "2029": 0.32905077934265137, "2034": 0.42225050926208496, ... | 44947611 | We have used NMR spectroscopy to determine the solution structure of protein AAH26994.1 from Mus musculus and propose that it represents the first three-dimensional structure of a ubiquitin-related modifier 1 (Urm1) protein. Amino acid sequence comparisons indicate that AAH26994.1 belongs to the Urm1 family of ubiquiti... | Three-dimensional structure of the AAH26994.1 protein from Mus musculus, a putative eukaryotic Urm1. |
{"1003": 0.1602703034877777, "1041": 0.18816383183002472, "1043": 0.7067264318466187, "1044": 0.37371641397476196, "1051": 0.040196798741817474, "1057": 0.3297532796859741, "1997": 0.46363574266433716, "2001": 0.1358480453491211, "2003": 0.018384648486971855, "2004": 0.23556606471538544, "2006": 0.06612417846918106, "2... | 45015767 | BACKGROUND Adenocarcinoma of the endometrium is the most common gynecologic malignancy in the United States, accounting for approximately 36,000 diagnoses of invasive carcinoma annually. The most common histologic type, endometrioid adenocarcinoma (EC), accounts for 75-80% of patients. The objective of this work was to... | Concurrent endometrial carcinoma in women with a biopsy diagnosis of atypical endometrial hyperplasia: a Gynecologic Oncology Group study. |
{"1018": 0.5517725944519043, "1050": 0.1930064558982849, "1997": 0.020300358533859253, "2013": 0.02412080205976963, "2020": 0.16442140936851501, "2028": 0.11256109178066254, "2062": 0.3034266233444214, "2075": 0.7692760229110718, "2090": 0.026976587250828743, "2093": 0.14518201351165771, "2098": 0.24018502235412598, "2... | 45027320 | BACKGROUND The aim of this study was to examine the clustering of four major lifestyle risk factors (smoking, heavy drinking, lack of fruit and vegetables consumption, and lack of physical activity), and to examine the variation across different socio-demographic groups in the English adult population. METHODS The stud... | The prevalence and clustering of four major lifestyle risk factors in an English adult population. |
{"1011": 0.6921701431274414, "1045": 0.1734936386346817, "1056": 0.6181373596191406, "2003": 0.3084607720375061, "2005": 0.09938567131757736, "2008": 0.15777134895324707, "2011": 0.5016035437583923, "2019": 0.3374483287334442, "2029": 0.2696990668773651, "2050": 0.28890204429626465, "2063": 0.09050461649894714, "2079":... | 45096063 | IL-17 is an inflammatory cytokine produced primarily by a unique lineage of CD4 T cells that plays critical roles in the pathogenesis of multiple autoimmune diseases. IL-17RA is a ubiquitously expressed receptor that is essential for IL-17 biologic activity. Despite widespread receptor expression, the activity of IL-17... | Cutting edge: interleukin 17 signals through a heteromeric receptor complex. |
{"1011": 0.28082266449928284, "1015": 0.022212404757738113, "1021": 0.20022670924663544, "1038": 0.42096930742263794, "1048": 0.9084475636482239, "1052": 0.5197699069976807, "1999": 0.1332872211933136, "2002": 0.6754127144813538, "2005": 0.015504186972975731, "2007": 0.16359257698059082, "2008": 0.016465263441205025, "... | 45143088 | Long non-coding RNAs (lncRNAs) are involved in regulating chromatin modifications, gene transcription, mRNA translation, and protein function. We recently reported a high variation in the basal expression levels of a panel of lncRNAs in HeLa and MCF-7 cells and their differential response to DNA damage induction. Here,... | Long non-coding RNAs with low expression levels in cells are enriched in secreted exosomes. |
{"1016": 0.0354953333735466, "1040": 0.09584271162748337, "1044": 0.09406650811433792, "1051": 0.1212492436170578, "1999": 0.12728634476661682, "2007": 0.1477125883102417, "2064": 0.11081436276435852, "2080": 0.18167030811309814, "2084": 0.052318159490823746, "2117": 0.777387797832489, "2119": 0.19862671196460724, "213... | 45153864 | Treatment with second-generation antipsychotic agents such as olanzapine frequently results in metabolic adverse effects, e.g. hyperphagia, weight gain and dyslipidaemia in patients of both genders. The molecular mechanisms underlying metabolic adverse effects are still largely unknown, and studies in rodents represent... | Olanzapine depot exposure in male rats: Dose-dependent lipogenic effects without concomitant weight gain. |
{"1015": 0.09761575609445572, "1018": 0.7426811456680298, "1039": 0.0317181795835495, "1043": 0.5534584522247314, "1054": 0.0174254160374403, "1996": 0.11081436276435852, "2003": 0.05694137513637543, "2008": 0.19220098853111267, "2011": 0.2637155055999756, "2029": 0.2954642176628113, "2058": 0.319873183965683, "2092": ... | 45154987 | The melanocortin receptor 4 (MC4R) is a well-established mediator of body weight homeostasis. However, the neurotransmitter(s) that mediate MC4R function remain largely unknown; as a result, little is known about the second-order neurons of the MC4R neural pathway. Single-minded 1 (Sim1)-expressing brain regions, which... | Glutamate mediates the function of melanocortin receptor 4 on Sim1 neurons in body weight regulation. |
{"1999": 0.10467668622732162, "2007": 0.5635144114494324, "2011": 0.0354953333735466, "2015": 0.0174254160374403, "2048": 0.28963330388069153, "2060": 0.5472630262374878, "2064": 0.19782574474811554, "2073": 0.151916041970253, "2076": 0.04487626627087593, "2079": 0.20660123229026794, "2090": 0.32129061222076416, "2121"... | 45166582 | We review the cellular mechanisms implicated in cholesterol trafficking and distribution. Recent studies have provided new information about the distribution of sterols within cells, including analysis of its transbilayer distribution. The cholesterol interaction with other lipids and its engagement in various traffick... | Intracellular sterol dynamics. |
{"1015": 0.6112717390060425, "1018": 0.37102460861206055, "1044": 0.36358460783958435, "2002": 1.1786550283432007, "2010": 0.11517547070980072, "2011": 0.44753631949424744, "2012": 0.3269403576850891, "2028": 0.1994270235300064, "2029": 0.13243216276168823, "2037": 0.0019512200960889459, "2046": 0.13243216276168823, "2... | 45199834 | Abstract Intact HeLa cells can bind virions of poliovirus type 1 and can subsequently convert them to altered particles by incubation at 37°. Altered particles sediment more slowly than virions, have lost VP-4, and are disrupted by sodium dodecyl sulfate, but their RNA is intact and ribonuclease insensitive. These char... | A plasma membrane component able to bind and alter virions of poliovirus type 1: studies on cell-free alteration using a simplified assay. |
{"1006": 0.08154398202896118, "1011": 0.2247048318386078, "1013": 0.043007105588912964, "1016": 0.5045560002326965, "1017": 0.0842406153678894, "1018": 0.6410312056541443, "1022": 0.9240728616714478, "1043": 0.1930064558982849, "1060": 0.14686977863311768, "1998": 0.02887592278420925, "2000": 0.15526613593101501, "2007... | 45200347 | Decreasing costs of next-generation sequencing (NGS) experiments have made a wide range of genomic questions open for study with nonmodel organisms. However, experimental designs and analysis of NGS data from less well-known species are challenging because of the lack of genomic resources. In this work, we investigate ... | Resequencing studies of nonmodel organisms using closely related reference genomes: optimal experimental designs and bioinformatics approaches for population genomics. |
{"1011": 0.026025565341114998, "1039": 0.40806588530540466, "1041": 0.12556517124176025, "1044": 0.5827828645706177, "1052": 0.6689305305480957, "1055": 0.49030399322509766, "2001": 0.03831886500120163, "2002": 0.31132611632347107, "2005": 0.27564704418182373, "2012": 0.04113444685935974, "2013": 0.17840765416622162, "... | 45218443 | The hemoglobinopathies are probably the world's most common genetic diseases: The World Health Organization has estimated that at least 5% of the population are carriers for one or other of the most serious forms, the alpha- and beta-thalassemias and the structural variant hemoglobins S, C, and E, which are found at po... | Thalassemia and malaria: new insights into an old problem. |
{"1042": 0.8433839678764343, "1048": 0.846739649772644, "1051": 0.32341301441192627, "1998": 0.8169882297515869, "1999": 0.08064348995685577, "2005": 0.043007105588912964, "2010": 0.4437839686870575, "2015": 0.11168810725212097, "2029": 0.22001366317272186, "2062": 0.41389304399490356, "2080": 0.08154398202896118, "208... | 45244537 | Evaluation of testicular functions (production of sperm and androgens) is an important aspect of preclinical safety assessment and testicular toxicity is comparatively far more common than ovarian toxicity. This chapter focuses (1) on the histological sequelae of disturbed reproductive endocrinology in rat, dog and non... | Endocrine control of spermatogenesis: Role of FSH and LH/ testosterone. |
{"1044": 0.08782484382390976, "1051": 0.16690383851528168, "1054": 0.5162794589996338, "1057": 0.5500838756561279, "2000": 0.2852376699447632, "2001": 0.040196798741817474, "2005": 0.41840189695358276, "2009": 0.009718249551951885, "2018": 0.06520967930555344, "2043": 0.40285754203796387, "2050": 0.21765978634357452, "... | 45276789 | This survey of regional neonatal intensive care units determined a prevalence of 38 per 1000 neonates who sustained an extravasation injury that caused skin necrosis. Most injuries occurred in infants of 26 weeks gestation or less, with parenteral nutrition infused through intravenous cannulae. Common treatments were e... | Extravasation injuries on regional neonatal units. |
{"1007": 0.1994270235300064, "1011": 0.4196864068508148, "1017": 0.7276995778083801, "1018": 0.41840189695358276, "1039": 1.1586239337921143, "1044": 0.5849615335464478, "1058": 0.07341018319129944, "1155": 0.1994270235300064, "1997": 0.02316705882549286, "2002": 1.3505052328109741, "2003": 0.22157983481884003, "2005":... | 45287266 | Hepatitis C virus (HCV) nonstructural protein 3-4A (NS3-4A) is a complex composed of NS3 and its cofactor NS4A. It harbours serine protease as well as NTPase/RNA helicase activities and is essential for viral polyprotein processing, RNA replication and virion formation. Specific inhibitors of the NS3-4A protease signif... | Nonstructural protein 3-4A: the Swiss army knife of hepatitis C virus. |
{"1011": 0.0913962796330452, "1013": 0.012615402229130268, "1040": 0.43875885009765625, "1043": 0.16607704758644104, "1048": 0.757441520690918, "1052": 0.4002431631088257, "1157": 0.29619070887565613, "2000": 0.36967599391937256, "2005": 0.3588210940361023, "2007": 0.08154398202896118, "2012": 0.021256839856505394, "20... | 45336190 | OBJECTIVE To evaluate the safety, tolerability, and amyloid beta (Abeta) response to the gamma-secretase inhibitor LY450139 in Alzheimer disease. DESIGN Multicenter, randomized, double-blind, dose-escalation, placebo-controlled trial. SETTING Community-based clinical research centers. Patients Fifty-one individuals wit... | Phase 2 safety trial targeting amyloid beta production with a gamma-secretase inhibitor in Alzheimer disease. |
{"1011": 0.08603433519601822, "1014": 0.4512746334075928, "1018": 0.21530038118362427, "1044": 0.7601850032806396, "1052": 0.23556606471538544, "1079": 0.22392450273036957, "1997": 0.15359249711036682, "2000": 0.0029254043474793434, "2001": 0.1485546976327896, "2002": 0.2516399025917053, "2005": 0.23633737862110138, "2... | 45341480 | AIM/PURPOSE The aim of this study was to compare clinical outcome of children with scald burns treated with a hydrofiber dressing (Aquacel(®), Convatec Inc.) with the former standard of care with silver sulfadiazine (Flammazine(®); Solvay Pharmaceuticals), considering surgical intervention and length of stay (LOS). MET... | Reduction in skin grafting after the introduction of hydrofiber dressings in partial thickness burns: a comparison between a hydrofiber and silver sulphadiazine. |
{"1011": 0.4920966327190399, "1017": 0.08782484382390976, "1039": 0.5016035437583923, "1056": 0.5930894017219543, "2015": 0.02792670577764511, "2029": 0.12556517124176025, "2044": 0.5461324453353882, "2064": 0.052318159490823746, "2066": 0.1384023278951645, "2072": 0.5376120805740356, "2075": 0.4126010537147522, "2076"... | 45364685 | The effects of a set of stress treatments on gene expression of Chironomus thummi salivary gland cells have been analyzed. Among the treatments assayed, only during recovery from carbon dioxide have we observed a response similar to that previously described after heat-shock treatment: induction of the heat-shock puffs... | Induction of the heat-shock response by carbon dioxide in Chironomus thummi. |
{"1011": 0.151916041970253, "1015": 0.17020416259765625, "1020": 0.39696553349494934, "1041": 0.5180262327194214, "1052": 0.23710809648036957, "1998": 0.18978065252304077, "2005": 0.052318159490823746, "2006": 0.05786345899105072, "2007": 0.27342069149017334, "2011": 0.22548456490039825, "2029": 0.12728634476661682, "2... | 45401535 | Despite advances in medical device fabrication and antimicrobial treatment therapies, fungal-bacterial polymicrobial peritonitis remains a serious complication for surgery patients, those on peritoneal dialysis, and the critically ill. Using a murine model of peritonitis, we have demonstrated that monomicrobial infecti... | Candida albicans-Staphylococcus aureus polymicrobial peritonitis modulates host innate immunity. |
{"1012": 0.043007105588912964, "1048": 0.29328158497810364, "1060": 1.0305955410003662, "1999": 0.04860413447022438, "2000": 0.0913962796330452, "2005": 0.18816383183002472, "2008": 0.11691460013389587, "2011": 0.0019512200960889459, "2015": 0.09938567131757736, "2029": 0.1332872211933136, "2030": 0.2317005842924118, "... | 45408403 | The frog Xenopus laevis has provided significant insights into developmental and cellular processes. However, X. laevis has an allotetraploid genome precluding its use in forward genetic analysis. Genetic analysis may be applicable to Xenopus (Silurana) tropicalis, which has a diploid genome and a shorter generation ti... | Techniques and probes for the study of Xenopus tropicalis development. |
{"1009": 0.4673144817352295, "1011": 0.4132472574710846, "1022": 0.1930064558982849, "1038": 0.021256839856505394, "1039": 0.7701805830001831, "1040": 0.43244171142578125, "1056": 0.9635916948318481, "1996": 0.23479416966438293, "1999": 0.21293537318706512, "2005": 0.3757305145263672, "2008": 0.17759032547473907, "2010... | 45414636 | Previous reports have suggested that the protooncogene c-myb participates in T cell development in the thymus and mature T cell proliferation. We have generated two T cell-specific c-myb knockout mouse models, myb/LckCre and myb/CD4Cre. We have demonstrated that c-myb is required for the development of thymocytes at th... | Requirement of c-myb in T cell development and in mature T cell function. |
{"1015": 0.4349733293056488, "1016": 0.05786345899105072, "1020": 0.39762192964553833, "1043": 0.2822965085506439, "1044": 0.33675122261047363, "1048": 0.7674643993377686, "1050": 0.18329764902591705, "1058": 0.16607704758644104, "2005": 0.20501139760017395, "2006": 0.1221139207482338, "2007": 0.10906458646059036, "202... | 45447613 | OBJECTIVE Previous studies have shown increases in ambulatory short-term blood pressure (BP) variability to be related to cardiovascular disease. In this study, we examined whether an angiotensin II type 1 receptor blocker losartan would improve ambulatory short-term BP variability in hypertensive patients on hemodialy... | Effect of losartan on ambulatory short-term blood pressure variability and cardiovascular remodeling in hypertensive patients on hemodialysis. |
{"1011": 0.3864043951034546, "1039": 0.18248429894447327, "1056": 0.669430673122406, "1999": 0.20501139760017395, "2004": 0.5506471395492554, "2007": 0.3077431619167328, "2011": 0.306306391954422, "2026": 1.0326838493347168, "2029": 0.28963330388069153, "2033": 0.1873544454574585, "2039": 0.052318159490823746, "2064": ... | 45449835 | Myelin-directed autoimmunity is considered to play a key role in the pathogenesis of multiple sclerosis (MS). Increased production of both pro- and anti-inflammatory cytokines is a common finding in MS. Interleukin-17 (IL-17) is a recently described cytokine produced in humans almost exclusively by activated memory T c... | Interleukin-17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis. |
{"1057": 0.3662964701652527, "1998": 0.14518201351165771, "2001": 0.1930064558982849, "2013": 0.1384023278951645, "2038": 0.23092569410800934, "2040": 0.013579257763922215, "2042": 0.2160874605178833, "2045": 0.35950297117233276, "2055": 0.055094651877880096, "2062": 0.022212404757738113, "2073": 0.36358460783958435, "... | 45457778 | The change in the world's age demographics and the predicted rise in the incidence of age-related diseases, including dementia, is a source of major public health concern. Major research effort in both the United States and Europe has been targeted toward understanding the pathogenesis and epidemiology of dementia. Thi... | A European perspective on population studies of dementia. |
{"1020": 0.1510767638683319, "2012": 0.06429435312747955, "2041": 0.09317722171545029, "2058": 0.058784693479537964, "2084": 0.0019512200960889459, "2120": 0.37035053968429565, "2140": 0.0174254160374403, "2146": 0.15860503911972046, "2149": 0.08961215615272522, "2169": 0.03831886500120163, "2172": 0.5968599319458008, ... | 45461275 | BACKGROUND PEPFAR, national governments, and other stakeholders are investing unprecedented resources to provide HIV treatment in developing countries. This study reports empirical data on costs and cost trends in a large sample of HIV treatment sites. DESIGN In 2006-2007, we conducted cost analyses at 43 PEPFAR-suppor... | The cost of providing comprehensive HIV treatment in PEPFAR-supported programs. |
{"1011": 0.10203468054533005, "1049": 0.24171993136405945, "1051": 0.8861536383628845, "1996": 0.20818853378295898, "1999": 0.16359257698059082, "2005": 0.2689530849456787, "2007": 0.04207121208310127, "2008": 0.02412080205976963, "2011": 0.2394166737794876, "2015": 0.045809537172317505, "2029": 0.2470736801624298, "20... | 45487164 | Caenorhabditis elegans oocytes, like those of most animals, arrest during meiotic prophase. Sperm promote the resumption of meiosis (maturation) and contraction of smooth muscle-like gonadal sheath cells, which are required for ovulation. We show that the major sperm cytoskeletal protein (MSP) is a bipartite signal for... | A sperm cytoskeletal protein that signals oocyte meiotic maturation and ovulation. |
{"1003": 0.06612417846918106, "1017": 0.02792670577764511, "1019": 0.22937409579753876, "1020": 0.22626367211341858, "1023": 0.029824240133166313, "1061": 0.1619328260421753, "1997": 0.06886265426874161, "1998": 0.13157635927200317, "2001": 0.10818854719400406, "2004": 0.255429208278656, "2020": 0.034552380442619324, "... | 45548062 | OBJECTIVE Policy discussions regarding the mental health needs of children and adolescents emphasize a lack of use of mental health services among youth, but few national estimates are available. The authors use three national data sets and examine ethnic disparities in unmet need (defined as having a need for mental h... | Unmet need for mental health care among U.S. children: variation by ethnicity and insurance status. |
{"1039": 0.1930064558982849, "1998": 0.2034190446138382, "2000": 0.06703783571720123, "2005": 0.0019512200960889459, "2047": 0.05786345899105072, "2064": 0.2954642176628113, "2071": 0.09228714555501938, "2072": 1.1714173555374146, "2109": 0.10467668622732162, "2129": 0.23556606471538544, "2224": 0.029824240133166313, "... | 45581752 | OBJECTIVE This article reviews psychology and behavioral economic approaches to HIV prevention, and examines the integration and application of these approaches in conditional economic incentive (CEI) programs for reducing HIV risk behavior. METHODS We discuss the history of HIV prevention approaches, highlighting the ... | Conditional economic incentives for reducing HIV risk behaviors: integration of psychology and behavioral economics. |
{"1060": 0.5347557663917542, "1998": 0.13157635927200317, "2005": 0.045809537172317505, "2007": 0.06795065850019455, "2011": 0.15526613593101501, "2029": 0.18816383183002472, "2031": 0.037378571927547455, "2038": 0.052318159490823746, "2109": 0.21372433006763458, "2139": 0.5278670787811279, "2152": 0.4709797203540802, ... | 45638119 | Application of stem cell biology to breast cancer research has been limited by the lack of simple methods for identification and isolation of normal and malignant stem cells. Utilizing in vitro and in vivo experimental systems, we show that normal and cancer human mammary epithelial cells with increased aldehyde dehydr... | ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome. |
{"1011": 0.25845035910606384, "1020": 0.9147270321846008, "1022": 0.9013357162475586, "1044": 0.22548456490039825, "1045": 0.17020416259765625, "1048": 0.12986256182193756, "1051": 0.8861536383628845, "1054": 0.5220900774002075, "1060": 0.7163142561912537, "1999": 0.4113073945045471, "2004": 0.05417001247406006, "2007"... | 45651303 | Concentrations of interleukin (IL)-6 and IL-8 in serum and synovial fluid obtained from patients with osteoarthritis (OA) of the knee were determined by the chemiluminescence-ELISA (CL-ELISA) method, the sensitivity of which is 100-1,000 times greater than that of the conventional ELISA method. The results were compare... | Interleukin-6 and interleukin-8 levels in serum and synovial fluid of patients with osteoarthritis. |
{"1011": 0.1602703034877777, "1022": 0.0913962796330452, "1026": 0.010684899985790253, "1038": 0.4349733293056488, "1039": 0.42225050926208496, "1047": 0.14264501631259918, "1048": 0.21135559678077698, "1052": 0.2800849378108978, "1054": 0.015504186972975731, "2007": 0.06337817758321762, "2011": 0.12384103983640671, "2... | 45764440 | The nonreceptor protein tyrosine kinase Src is overexpressed in 70% of pancreatic adenocarcinomas. Here, we describe the effect of molecular and pharmacological down-regulation of Src on incidence, growth, and metastasis of pancreatic tumor cells in an orthotopic model. Src expression in L3.6pl human pancreatic tumor c... | Inhibition of SRC expression and activity inhibits tumor progression and metastasis of human pancreatic adenocarcinoma cells in an orthotopic nude mouse model. |
{"1038": 0.2561853528022766, "1041": 0.9209672808647156, "1062": 0.5528968572616577, "1179": 0.10906458646059036, "1997": 0.056018441915512085, "1999": 0.14686977863311768, "2004": 0.10906458646059036, "2005": 0.42990362644195557, "2011": 0.19381128251552582, "2013": 0.15442965924739838, "2029": 0.22626367211341858, "2... | 45770026 | Eicosapentaenoic acid (EPA) has beneficial effects in many inflammatory disorders. In this study, dietary EPA was converted to 17,18-epoxyeicosatetraenoic acid (17,18-EpETE) by ω-3 epoxygenation in the mouse peritoneal cavity. Mediator lipidomics revealed a series of novel oxygenated metabolites of 17,18-EpETE, and one... | Eicosapentaenoic acid is converted via ω-3 epoxygenation to the anti-inflammatory metabolite 12-hydroxy-17,18-epoxyeicosatetraenoic acid. |
{"1019": 0.40220460295677185, "1020": 0.10555581003427505, "1023": 0.1011524572968483, "1039": 0.5903874635696411, "1042": 0.24859806895256042, "1058": 0.8161250352859497, "1999": 0.5489565134048462, "2001": 0.18329764902591705, "2004": 0.0354953333735466, "2005": 0.20977331697940826, "2007": 0.18816383183002472, "2010... | 45820464 | Five strains of scrapie agent were used as intracerebral inocula for 2 inbred mouse strains, C57BL and VM, and their F1 cross. The degree of vacuolation in specified regions of the brain, and the relative distribution of this damage in 9 regions represented as a “lesion profile”, was different for each agent. Any of th... | Scrapie in mice. Agent-strain differences in the distribution and intensity of grey matter vacuolation. |
{"1016": 0.11517547070980072, "1039": 0.19622190296649933, "1047": 0.08871890604496002, "1055": 0.8083226680755615, "1056": 0.24171993136405945, "2004": 0.007782140281051397, "2007": 0.04953393340110779, "2008": 0.10818854719400406, "2012": 0.27564704418182373, "2025": 0.14602625370025635, "2029": 0.3262358605861664, "... | 45875990 | Cyclin A2 activates the cyclin-dependent kinases Cdk1 and Cdk2 and is expressed at elevated levels from S phase until early mitosis. We found that mutant mice that cannot elevate cyclin A2 are chromosomally unstable and tumor-prone. Underlying the chromosomal instability is a failure to up-regulate the meiotic recombin... | Cyclin A2 is an RNA binding protein that controls Mre11 mRNA translation |
{"1003": 0.24018502235412598, "1009": 0.11343330889940262, "1041": 0.2969166338443756, "2006": 0.29981520771980286, "2035": 0.04394211992621422, "2072": 1.244919776916504, "2109": 0.3027053773403168, "2111": 0.18248429894447327, "2116": 0.613389253616333, "2119": 0.1619328260421753, "2129": 0.2531573474407196, "2169": ... | 45908102 | The Expanded Program on Immunization (EPI) is using a simplified cluster sampling method, based on the random selection of 210 children in 30 clusters of 7 children each, to estimate immunization coverage levels. This article analyzes the results of this method in actual and computer simulated surveys. Results from 60 ... | Cluster sampling to assess immunization coverage: a review of experience with a simplified sampling method. |
{"1011": 0.09584271162748337, "1050": 0.2018241584300995, "1998": 0.2990913391113281, "2031": 0.09850110858678818, "2045": 0.04674193635582924, "2047": 0.21135559678077698, "2057": 0.04394211992621422, "2058": 0.18654440343379974, "2062": 0.7818660736083984, "2084": 0.6296497583389282, "2086": 0.11865071207284927, "208... | 45920278 | BACKGROUND Studies have shown that women use more health care services than men. We used important independent variables, such as patient sociodemographics and health status, to investigate gender differences in the use and costs of these services. METHODS New adult patients (N = 509) were randomly assigned to primary ... | Gender differences in the utilization of health care services. |
{"1011": 0.4450363218784332, "1015": 0.12556517124176025, "1016": 0.1011524572968483, "1042": 0.06886265426874161, "1045": 0.06520967930555344, "1054": 1.2146576642990112, "1056": 0.2223619967699051, "1999": 0.3269403576850891, "2003": 0.32764431834220886, "2004": 0.00875066313892603, "2005": 0.14686977863311768, "2012... | 46112052 | Recombinant human tumor necrosis factor (rH-TNF) is a cytokine with direct antitumor properties. In a phase I trial we continuously infused rH-TNF for 24 hours. We gave a total of 115 courses of therapy to 50 patients. Doses ranged from 4.5 to 645 micrograms of rH-TNF/m2. Systemic toxicity, including fever, chills, fat... | Recombinant human tumor necrosis factor administered as a 24-hour intravenous infusion. A phase I and pharmacologic study. |
{"1041": 0.8997484445571899, "1043": 0.0019512200960889459, "1052": 0.04860413447022438, "2000": 0.12556517124176025, "2005": 0.2786078155040741, "2007": 0.15777134895324707, "2029": 0.06703783571720123, "2062": 0.07431721687316895, "2064": 0.28743788599967957, "2071": 0.3297532796859741, "2075": 0.14686977863311768, "... | 46127781 | Cells or cell-free fluid of malignant pleural effusion could be important clinical specimen for epidermal growth factor receptor (EGFR) mutation screening in advanced non-small cell lung cancer (NSCLC) patients. However, their usefulness in mutation detection has not been well compared. In this study we recruited 26 Ea... | Detection and comparison of epidermal growth factor receptor mutations in cells and fluid of malignant pleural effusion in non-small cell lung cancer. |
{"1017": 0.025073638185858727, "1021": 0.5450005531311035, "1023": 0.6719275116920471, "1045": 0.4824984669685364, "1048": 0.37371641397476196, "1050": 0.7656494975090027, "1056": 0.9900637865066528, "1164": 0.7791815400123596, "1996": 0.07884006202220917, "2005": 0.02887592278420925, "2008": 0.011650617234408855, "201... | 46135768 | Endosomal Toll-like receptors (TLRs) 7 and 9 recognize viral pathogens and induce signals leading to the activation of nuclear factor κB (NF-κB)-dependent proinflammatory cytokines and interferon regulatory factor 7 (IRF7)-dependent type I interferons (IFNs). Recognition of viral nucleic acids by TLR9 requires its clea... | Materials and Methods Figs. S1 to S15 References Supporting Online Materials |
{"1017": 0.17020416259765625, "1998": 0.0019512200960889459, "2003": 0.034552380442619324, "2005": 0.0913962796330452, "2007": 0.25239890813827515, "2029": 0.06154331564903259, "2043": 0.19381128251552582, "2048": 0.5244048833847046, "2064": 0.40089741349220276, "2075": 0.14518201351165771, "2079": 0.2247048318386078, ... | 46153874 | Sedimentation analysis in the analytical ultracentrifuge can be employed to detect macromolecular interactions. Whenever two molecules interact the mass of the resulting complex is increased and this is reflected in the sedimentation behavior. In this chapter we discuss how this phenomenon can be utilized to determine ... | Sedimentation velocity method in the analytical ultracentrifuge for the study of protein-protein interactions. |
{"1016": 0.021256839856505394, "1017": 0.043007105588912964, "1019": 0.13243216276168823, "1020": 0.09672962874174118, "1038": 0.890972912311554, "1039": 0.034552380442619324, "1040": 0.7314660549163818, "1057": 0.29473719000816345, "1060": 0.4487839937210083, "1999": 0.4437839686870575, "2006": 0.13414156436920166, "2... | 46182525 | Hip scans of U.S. adults aged 20-99 years acquired in the Third National Health and Nutrition Examination Survey (NHANES III) using dual-energy X-ray absorptiometry (DXA) were analyzed with a structural analysis program. The program analyzes narrow (3 mm wide) regions at specific locations across the proximal femur to ... | Structural trends in the aging femoral neck and proximal shaft: analysis of the Third National Health and Nutrition Examination Survey dual-energy X-ray absorptiometry data. |
{"1011": 0.05970508232712746, "1048": 0.34922540187835693, "1996": 0.056018441915512085, "2005": 0.04487626627087593, "2008": 0.007782140281051397, "2013": 0.1401015669107437, "2015": 0.05139094591140747, "2026": 0.5381823778152466, "2029": 0.1221139207482338, "2037": 0.0009760859538801014, "2039": 0.053244512528181076... | 46193388 | Bone marrow stem cells give rise to a variety of hematopoietic lineages and repopulate the blood throughout adult life. We show that, in a strain of mice incapable of developing cells of the myeloid and lymphoid lineages, transplanted adult bone marrow cells migrated into the brain and differentiated into cells that ex... | Turning blood into brain: cells bearing neuronal antigens generated in vivo from bone marrow. |
{"1003": 0.08244366943836212, "1052": 0.2763880789279938, "1060": 0.5197699069976807, "1997": 0.09050461649894714, "1999": 0.10026945173740387, "2000": 0.23324857652187347, "2003": 0.13925230503082275, "2005": 0.23864774405956268, "2006": 0.02887592278420925, "2007": 0.056018441915512085, "2012": 0.009718249551951885, ... | 46193478 | Abstract A simple technique has been developed for the study of the external form and structure of virus particles. High contrast with good preservation is obtained by mixing virus preparations with 1% phosphotungstic acid adjusted to pH 7.5 and spraying directly onto electron microscope supporting films made from evap... | A negative staining method for high resolution electron microscopy of viruses. |
{"1009": 0.36426326632499695, "1011": 0.00875066313892603, "1015": 0.7009293437004089, "1039": 0.4794800877571106, "1045": 0.05786345899105072, "1056": 0.5393219590187073, "1999": 0.05786345899105072, "2028": 0.3485364317893982, "2029": 0.2223619967699051, "2033": 0.5607312321662903, "2039": 0.22626367211341858, "2071"... | 46202852 | Several recent reports indicate that cholesterol might play an important role in human immunodeficiency virus type 1 (HIV-1) replication. We investigated the effects of HIV-1 infection on cholesterol biosynthesis and uptake using microarrays. HIV-1 increased gene expression of cholesterol genes in both transformed T-ce... | Nef induces multiple genes involved in cholesterol synthesis and uptake in human immunodeficiency virus type 1-infected T cells. |
{"1011": 0.12814582884311676, "1016": 0.05970508232712746, "1017": 0.2539152204990387, "1019": 0.18492233753204346, "1044": 0.09228714555501938, "1048": 0.5370414853096008, "1996": 0.1677299439907074, "1997": 0.1064341589808464, "1999": 0.013579257763922215, "2004": 0.13755162060260773, "2005": 0.33675122261047363, "20... | 46248894 | Long intergenic noncoding RNAs (lincRNAs) regulate chromatin states and epigenetic inheritance. Here, we show that the lincRNA HOTAIR serves as a scaffold for at least two distinct histone modification complexes. A 5' domain of HOTAIR binds polycomb repressive complex 2 (PRC2), whereas a 3' domain of HOTAIR binds the L... | Long noncoding RNA as modular scaffold of histone modification complexes |
{"1011": 0.10379679501056671, "1016": 0.014542185701429844, "1020": 0.5860490798950195, "1043": 0.27934664487838745, "1045": 0.4831010699272156, "1048": 0.2231435477733612, "1052": 0.6410312056541443, "1054": 0.47402387857437134, "1061": 0.4794800877571106, "1999": 0.16524957120418549, "2000": 0.12038381397724152, "200... | 46266579 | BACKGROUND The amyloid fibril deposits that cause systemic amyloidosis always contain the nonfibrillar normal plasma protein, serum amyloid P component (SAP). The drug (R)-1-[6-[(R)-2-carboxy-pyrrolidin-1-yl]-6-oxo-hexanoyl]pyrrolidine-2-carboxylic acid (CPHPC) efficiently depletes SAP from the plasma but leaves some S... | Therapeutic Clearance of Amyloid by Antibodies to Serum Amyloid P Component. |
{"1006": 0.08603433519601822, "1011": 0.18492233753204346, "1014": 0.11951763927936554, "1017": 0.0019512200960889459, "1037": 0.32270604372024536, "1038": 0.23710809648036957, "1048": 0.16276304423809052, "1052": 0.4574742913246155, "1055": 0.66441810131073, "1997": 0.02316705882549286, "2007": 0.22859740257263184, "2... | 46277811 | Background: The relationship of LPA single nucleotide polymorphisms (SNPs), apolipoprotein(a) isoforms, and lipoprotein(a) [Lp(a)] levels with major adverse cardiovascular events (MACE) in different ethnic groups is not well known. Methods: LPA SNPs, apolipoprotein(a) isoforms, Lp(a), and oxidized phospholipids on apol... | LPA Gene, Ethnicity, and Cardiovascular Events |
{"1011": 0.15526613593101501, "1015": 0.16690383851528168, "1017": 0.1229778528213501, "1038": 0.10906458646059036, "1047": 0.013579257763922215, "1054": 0.31560876965522766, "2003": 0.11604541540145874, "2005": 0.05417001247406006, "2008": 0.0913962796330452, "2011": 0.4177590310573578, "2025": 0.013579257763922215, "... | 46305977 | The maize abscisic acid responsive protein Rab17 is a highly phosphorylated late embryogenesis abundant protein involved in plant responses to stress. In this study, we provide evidence of the importance of Rab17 phosphorylation by protein kinase CK2 in growth-related processes under stress conditions. We show the spec... | Protein kinase CK2 modulates developmental functions of the abscisic acid responsive protein Rab17 from maize. |
{"1009": 0.4041621685028076, "1044": 0.7978238463401794, "1048": 0.25845035910606384, "1050": 0.6764062643051147, "1052": 0.2689530849456787, "1060": 0.41195443272590637, "1997": 0.06977381557226181, "1998": 0.26296505331993103, "1999": 0.39367714524269104, "2005": 0.010684899985790253, "2007": 0.3810817003250122, "201... | 46328296 | Patients with essential hypertension exhibit blunted endothelium-dependent vasodilator responses, which may be largely attributable to reduced bioactivity of nitric oxide (NO). Therefore, we measured the end product of NO, nitrate plus nitrite (nitrogen oxide), and examined the relationship between the degree of hypert... | Reduced plasma concentrations of nitrogen oxide in individuals with essential hypertension. |
{"1011": 0.11778303235769272, "1041": 0.8247235417366028, "1051": 0.19622190296649933, "1999": 0.006812678650021553, "2001": 0.11691460013389587, "2005": 0.012615402229130268, "2006": 0.043007105588912964, "2011": 0.30989447236061096, "2020": 0.14349138736724854, "2025": 0.16690383851528168, "2029": 0.22392450273036957... | 46346525 | Mu transposons carrying the chloramphenicol resistance marker have been inserted into the cloned Escherichia coli genes sodA and sodB coding for manganese superoxide dismutase (MnSOD) and iron superoxide dismutase (FeSOD) respectively, creating mutations and gene fusions. The mutated sodA or sodB genes were introduced ... | Isolation of superoxide dismutase mutants in Escherichia coli: is superoxide dismutase necessary for aerobic life? |
{"1009": 0.4926934838294983, "1011": 0.1510767638683319, "1018": 0.2516399025917053, "1026": 0.06154331564903259, "1039": 0.151916041970253, "1056": 0.5751199722290039, "1609": 0.11081436276435852, "2003": 0.03360854089260101, "2004": 0.4494072198867798, "2007": 0.03360854089260101, "2012": 0.0317181795835495, "2034": ... | 46353045 | Late presentation remains a major concern despite the dramatically improved prognosis realized by ART. We define a first presentation for HIV care during the course of HIV infection as 'late' if an AIDS-defining opportunistic disease is apparent, or if CD4+ T-cells are <200/microl. In the Western world, approximately 1... | Late presentation of HIV-infected individuals. |
{"1003": 0.11343330889940262, "1009": 0.48068851232528687, "1039": 0.28670501708984375, "1044": 0.10731173306703568, "1052": 0.10203468054533005, "1058": 0.16607704758644104, "1999": 0.026976587250828743, "2000": 0.026976587250828743, "2001": 0.022212404757738113, "2007": 0.08064348995685577, "2014": 0.0411344468593597... | 46355579 | Health professionals and the public need to understand the natural history of human papillomavirus (HPV) infections of the cervix to best use the information provided by new molecular screening tests. We investigated outcomes of 800 carcinogenic HPV infections detected in 599 women at enrollment into a population-based... | Rapid clearance of human papillomavirus and implications for clinical focus on persistent infections. |
{"2001": 0.2822965085506439, "2011": 0.015504186972975731, "2013": 0.07250232994556427, "2020": 0.29109421372413635, "2035": 0.3283478021621704, "2039": 0.05786345899105072, "2042": 0.13157635927200317, "2043": 0.38308101892471313, "2045": 0.21135559678077698, "2067": 0.7925328612327576, "2076": 0.45870962738990784, "2... | 46437558 | AIMS Alcohol is believed to be an important factor behind the sharp rise in mortality during the period 1990-94 in Russia. However, the rise in the standard alcohol consumption proxy does not seem to be sufficient to explain all the increase in mortality. This study adopts a novel approach to exploring the role of the ... | The role of alcohol in the Russian mortality crisis. |
{"1011": 0.08692999184131622, "1014": 0.26296505331993103, "1019": 0.022212404757738113, "1040": 0.38308101892471313, "1043": 0.5718178153038025, "1044": 0.4500300884246826, "1048": 1.1217793226242065, "1050": 0.026025565341114998, "1999": 0.0797421783208847, "2004": 0.5925496220588684, "2006": 0.0606246218085289, "200... | 46451940 | Lateral hypothalamic (LH) injections of the excitatory neurotransmitter glutamate, or its excitatory amino acid (EAA) agonists, kainic acid (KA), D,L-alpha-amino-3-hydroxy-5-methyl-isoxazole propionic acid (AMPA), or N-methyl-D-aspartic acid (NMDA), can rapidly elicit an intense feeding response in satiated rats. To de... | The lateral hypothalamus: a primary site mediating excitatory amino acid-elicited eating. |
{"1011": 0.3163207769393921, "1021": 0.4400174915790558, "1052": 0.757441520690918, "1056": 0.7333439588546753, "1062": 0.22937409579753876, "1998": 0.006812678650021553, "2000": 0.20818853378295898, "2003": 0.17020416259765625, "2005": 0.23556606471538544, "2007": 0.007782140281051397, "2008": 0.040196798741817474, "2... | 46478393 | RNA interference is the most rapid method for generation of conditional knockdown mutants in Trypanosoma brucei. The dual T7 promoter (pZJM) and the stem-loop vectors have been widely used to generate stable inducible RNAi cell lines with the latter providing tighter regulatory control. However, the steps for cloning s... | A Gateway® compatible vector for gene silencing in bloodstream form Trypanosoma brucei. |
{"1019": 0.2160874605178833, "1052": 0.07068414986133575, "2000": 0.00875066313892603, "2005": 0.1718502640724182, "2034": 0.09672962874174118, "2038": 0.03831886500120163, "2039": 0.18654440343379974, "2042": 0.1358480453491211, "2043": 0.1229778528213501, "2044": 0.8829278349876404, "2051": 0.40089741349220276, "2067... | 46485368 | BACKGROUND Calcium supplementation has been shown to decrease the risk of recurrence of colorectal adenomas in randomized trials. However, the duration of this protective effect after cessation of active supplementation is not known. METHODS In the Calcium Polyp Prevention Study, 930 subjects with a previous colorectal... | Prolonged effect of calcium supplementation on risk of colorectal adenomas in a randomized trial. |
{"1017": 0.3615458607673645, "1043": 0.49982786178588867, "1999": 0.12384103983640671, "2007": 0.2837681770324707, "2011": 0.5313173532485962, "2015": 0.06429435312747955, "2029": 0.17759032547473907, "2063": 0.3982778787612915, "2064": 0.2145126610994339, "2071": 0.11951763927936554, "2076": 0.06520967930555344, "2079... | 46517055 | Uncontrolled proteolysis by neutrophil serine proteases (NSPs) in lung secretions is a hallmark of cystic fibrosis (CF). We have shown that the active neutrophil elastase, protease 3, and cathepsin G in CF sputum resist inhibition in part by exogenous protease inhibitors. This resistance may be due to their binding to ... | Influence of DNA on the activities and inhibition of neutrophil serine proteases in cystic fibrosis sputum. |
{"1009": 0.2478361576795578, "1011": 0.1602703034877777, "1014": 0.3409265875816345, "1016": 0.1889725625514984, "1020": 0.0174254160374403, "1026": 0.013579257763922215, "1043": 0.3656192123889923, "1052": 0.09228714555501938, "1053": 0.7067264318466187, "1062": 0.5784112811088562, "1156": 0.014542185701429844, "2000"... | 46565020 | BACKGROUND AN1792 (beta-amyloid [Abeta]1-42) immunization reduces Abeta plaque burden and preserves cognitive function in APP transgenic mice. The authors report the results of a phase IIa immunotherapy trial of AN1792(QS-21) in patients with mild to moderate Alzheimer disease (AD) that was interrupted because of menin... | Clinical effects of Abeta immunization (AN1792) in patients with AD in an interrupted trial. |
{"1053": 0.24401791393756866, "2000": 0.30917787551879883, "2022": 0.08154398202896118, "2064": 0.3519764244556427, "2067": 0.5080875158309937, "2075": 0.28743788599967957, "2094": 0.2018241584300995, "2098": 0.5080875158309937, "2109": 0.16524957120418549, "2129": 0.28963330388069153, "2147": 0.02316705882549286, "227... | 46565968 | Quantitative assessment of metastatic disease in bone is often considered immeasurable and, as such, patients with skeletal metastases are often excluded from clinical trials. In order to effectively quantify the impact of metastatic tumor involvement in the spine, accurate segmentation of the vertebra is required. Man... | Quantitative characterization of metastatic disease in the spine. Part I. Semiautomated segmentation using atlas-based deformable registration and the level set method. |
{"1011": 0.2531573474407196, "1016": 0.3423145115375519, "1040": 0.20818853378295898, "1048": 0.5370414853096008, "1049": 0.791648268699646, "1056": 0.7978238463401794, "1996": 0.2516399025917053, "1999": 0.00875066313892603, "2002": 0.1011524572968483, "2005": 0.07431721687316895, "2010": 0.8682814836502075, "2011": 0... | 46594244 | In response to a variety of stimuli, dendritic cells (DCs) transform from immature cells specialized for antigen capture into mature cells specialized for T cell stimulation. During maturation, the DCs acquire an enhanced capacity to form and accumulate peptide-MHC (major histocompatibility complex) class II complexes.... | Activation of lysosomal function during dendritic cell maturation. |
{"1011": 0.23710809648036957, "1022": 0.0317181795835495, "1039": 0.0009760859538801014, "1040": 0.025073638185858727, "1042": 0.3615458607673645, "1060": 0.05694137513637543, "1997": 0.14179791510105133, "1998": 0.20421554148197174, "1999": 0.3325583338737488, "2007": 0.3070250153541565, "2029": 0.23556606471538544, "... | 46602807 | The activities of cefotaxime (CTX) and desacetyl cefotaxime (des-CTX) were tested both singly and in combination against 173 anaerobic clinical isolates. The MIC of CTX for 50% of 60 Bacteroides fragilis isolates was 22.4 micrograms/ml in broth, compared with 47.4 micrograms/ml in agar. This reduced efficacy in agar wa... | Comparison of agar dilution, microdilution, and disk elution methods for measuring the synergy of cefotaxime and its metabolite against anaerobes. |
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